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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKX3-1 Gene

protein-coding   GIFtS: 60
GCID: GC08M023536

NK3 homeobox 1

(Previous names: NK homeobox (Drosophila), family 3, A, NK3 transcription...)
(Previous symbol: NKX3A)
 Explore 19 diseases affiliated with
NKX3-1 via
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 Human Malady Compendium 
Biological research products
for NKX3-1    

Aliases
for NKX3-1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NK3 Homeobox 11 2     NK3 Transcription Factor Related, Locus 1 (Drosophila)1
NKX3A1 2 3 5     NKX32
NKX3.11 2 3     Homeobox Protein Nkx-3.12
BAPX21 2 5     NK Homeobox, Family 3, A2
Homeobox Protein NK-3 Homolog A2 3     NK3 Transcription Factor Homolog A2
NK Homeobox (Drosophila), Family 3, A1     NK3 Transcription Factor Related, Locus 12

External Ids:    HGNC: 78381   Entrez Gene: 48242   Ensembl: ENSG000001670347   OMIM: 6020415   UniProtKB: Q998013   

Export aliases for NKX3-1 gene to outside databases

Previous GC identifers: GC08M023268 GC08M023889 GC08M023558 GC08M023592 GC08M022081


Summaries
for NKX3-1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NKX3-1:
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative
regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate
tumor progression. Alternate splicing results in multiple transcript variants of this gene. (provided by RefSeq, Jan
2012)

UniProtKB/Swiss-Prot: NKX31_HUMAN, Q99801
Function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a
transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of
glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate
carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells

Gene Wiki entry for NKX3-1


Genomic Views
for NKX3-1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKX3-1 gene promoter:
         SRF   p53   HTF   SRF (504 AA)   C/EBPalpha   PPAR-gamma1   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKX3-1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKX3-1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX3-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

NKX3-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX3-1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M023536:  view genomic region     (about GC identifiers)

Start:
 23,536,206 bp from pter      End:
 23,540,450 bp from pter
Size:
 4,245 bases      Orientation:
 minus strand

Proteins
for NKX3-1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NKX31_HUMAN, Q99801 (See protein sequence)
Recommended Name: Homeobox protein Nkx-3.1  
Size: 234 amino acids; 26350 Da
Subunit: Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77.
Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for NKX3-1:
2L9R (3D)    
Secondary accessions: O15465 Q9H2P4 Q9H2P5 Q9H2P6 Q9H2P7 Q9HBG0
Alternative splicing: 5 isoforms:  Q99801-1   Q99801-2   Q99801-3   Q99801-4   Q99801-5   

Explore the universe of human proteins at neXtProt for NKX3-1: NX_Q99801

Post-translational modifications:

  • Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99801

    • NKX3-1 Protein expression data from MOPED and PaxDb:    About this image 
    NKX3-1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243268.1  NP_006158.2  

    ENSEMBL proteins: 
     ENSP00000370253   ENSP00000429729  

    Human Recombinant Protein Products for NKX3-1: 
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    Novus Biologicals NKX3-1 Protein
    Novus Biologicals NKX3-1 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NKX3-1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA19597465
    GO:0005634nucleus NAS11137288

    NKX3-1 for ontologies           About GeneDecksing



    NKX3-1 Antibody Products: 
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    Abcam antibodies for NKX3-1 
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    Uscn ELISAs and CLIAs for NKX3-1

    Protein Domains /
    Families
    for NKX3-1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NKX3-1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_metazoa
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q99801

    ProtoNet protein and cluster: Q99801

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: NKX31_HUMAN, Q99801
    Similarity: Belongs to the NK-3 homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for NKX3-1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKX31_HUMAN, Q99801
    Function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a
    transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of
    glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate
    carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells
    Induction: By androgens and, in the LNCaP cell line, by estrogens. Androgenic control may be lost in prostate cancer
    cells during tumor progression from an androgen-dependent to an androgen-independent phase

         Gene Ontology (GO): 5/18 molecular function terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IDA--
    GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IEA--
    GO:0000988protein binding transcription factor activity IDA19797053
    GO:0001047core promoter binding IDA18974119
    GO:0003677DNA binding ----
         
    NKX3-1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NKX3-1:
     Decreased mitotic index 

         11 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Nkx3-1):
     behavior/neurological  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     limbs/digits/tail  mortality/aging  no phenotypic analysis  reproductive system  skeleton 
     tumorigenesis 

    NKX3-1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for NKX3-1: Nkx3-1Nkx3-tm1Siz Nkx3-1Nkx3-tm1.1Saa Nkx3-1Nkx3-tm1Mms
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NKX3-1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKX3-1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX3-1 (see all 39):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-488 hsa-miR-550a* hsa-miR-372 hsa-miR-3622b-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NKX3-1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKX3-1
    OriGene shRNA RFP: NKX3-1
    OriGene siRNA: NKX3-1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against NKX3-1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NKX3-1
    Sirion Biotech Customized adenovirus for overexpression of NKX3-1 
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    Clone
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    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for NKX3-1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX3-1


    Pathways & Interactions
    for NKX3-1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SIDS Susceptibility Pathways
    		SIDS Susceptibility Pathways1.00
    2Coregulation of Androgen receptor activity
    		Coregulation of Androgen receptor activity1.00
    3FOXA1 transcription factor network
    		FOXA1 transcription factor network1.00
    4Pathways in cancer
    		Pathways in cancer1.00
    5Glioma
    		Prostate cancer0.39

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for NKX3-1 
        SIDS Susceptibility Pathways
    FOXA1 transcription factor network
    Coregulation of Androgen receptor activity


    2         Kegg Pathways  (Kegg details for NKX3-1):
        Pathways in cancer
    Prostate cancer


    NKX3-1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NKX3-1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/18 Interacting proteins for NKX3-1 (Q998011, 3 ENSP000003702534) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOP1P113871, 3, ENSP000003545224EBI-1385894,EBI-876302 I2D: score=1 STRING: ENSP00000354522
    SP4Q024463, ENSP000002225844I2D: score=1 STRING: ENSP00000222584
    SP5Q6BEB43, ENSP000003644304I2D: score=1 STRING: ENSP00000364430
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    KAT2BQ928313, ENSP000002637544I2D: score=1 STRING: ENSP00000263754
    About this table

    Gene Ontology (GO): 5/49 biological process terms (GO ID links to tree view) (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001655urogenital system development ----
    GO:0001656metanephros development IEA--
    GO:0001756somitogenesis IEA--
    GO:0001934positive regulation of protein phosphorylation IDA--
    GO:0006355regulation of transcription, DNA-dependent NAS11137288

    NKX3-1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NKX3-1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NKX3-1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKX3-1
    4 Novoseek chemical compound relationships for NKX3-1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 44.8 10 10688034 (2), 19886863 (1), 11507036 (1), 19826044 (1) (see all 8)
    retinoic acid 30.3 4 16817226 (1), 17468839 (1)
    retinoid 28.9 4 16817226 (2)
    progesterone 0 1 11137288 (1)

    Search CenterWatch for drugs/clinical trials and news about NKX3-1 / NKX31 

    Transcripts
    for NKX3-1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NKX3-1 gene (2 alternative transcripts): 
    NM_001256339.1  NM_006167.3  

    Unigene Cluster for NKX3-1:

    NK3 homeobox 1
    Hs.55999  [show with all ESTs]
    Unigene Representative Sequence: NM_006167
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380871(uc011kzx.2) ENST00000523261

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX3-1 (see all 39):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-488 hsa-miR-550a* hsa-miR-372 hsa-miR-3622b-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NKX3-1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AF247704.1 AF249669.1 AF249670.1 AF249671.1 AF249672.1 BC074863.2 BC074864.2 BC111569.1 
    BC111574.1 NR_046072.1 U80669.1 U91540.1 

    5 DOTS entries:

    DT.416292  DT.75129064  DT.100699282  DT.95156476  DT.95082017 

    24/83 AceView cDNA sequences (see all 83):

    BC074864 AI989275 BC074863 BX102941 BF003027 AA442287 CF122460 AI685682 
    AA400418 BX641277 AI620178 CF146489 U91540 BF679599 AI989281 AI989272 
    BQ018482 BM983868 BF514063 CF138789 CF145380 AA507804 AI672753 AA813266 

    GeneLoc Exon Structure


    Expression
    for NKX3-1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKX3-1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTTATTAG
    NKX3-1 Expression
    About this image

    NKX3-1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
    SomiteCervical Mesenchymal SclerotomeCervical Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteCervical SomitesCervical Somite CellsSomite
    SomiteLumbar Mesenchymal SclerotomeLumbar Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteLumbar SomitesLumbar Somite CellsSmooth Muscle, Somite
    SomiteSacral Mesencymal SclerotomeSacral Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteSacral SomitesSacral Somite CellsSmooth Muscle, Somite
    SomiteSomitesSomite CellsSmooth Muscle, Somite
    SomiteThoracic Mesenchymal SclerotomeThoracic Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteThoracic SomitesThoracic Somite CellsSmooth Muscle, Somite
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)

    See NKX3-1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKX3-1

    SOURCE GeneReport for Unigene cluster: Hs.55999

    UniProtKB/Swiss-Prot: NKX31_HUMAN, Q99801
    Tissue specificity: Highly expressed in the prostate and, at a lower level, in the testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including NKX3-1: 
              Prostate Cancer in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX3-1

    Orthologs
    for NKX3-1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NKX3-1 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia NKX3-16
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343754.1(164831-165016)
    African clawed frog
    (Xenopus laevis)    		 Amphibia nkx3-1-prov2 NK3 transcription factor related, locus 1 (Drosophila) 79.64(n)    BC047968.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nkx3-11 NK3 homeobox 1 54.48(n)
    50.86(a)    		   555375  XM_677868.3  XP_682960.3 


    ENSEMBL Gene Tree for NKX3-1 (if available)
    TreeFam Gene Tree for NKX3-1 (if available) 

    Paralogs
    for NKX3-1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKX3-1 gene
    NKX2-12  HMX32  LBX22  TLX22  TLX12  NKX2-32  HMX22  NKX3-22  
    NKX2-62  NKX2-82  NKX2-52  LBX12  NKX2-22  NKX2-42  HMX12  TLX32  
    1 SIMAP similar gene for NKX3-1 using alignment to 1 protein entry:     NKX31_HUMAN:
    NKX2-6

    NKX3-1 for paralogs           About GeneDecksing



    Genomic Variants
    for NKX3-1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/121 NCBI SNPs in NKX3-1 are shown (see all 121)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs792765811,2
    		--23535729(+) CTCTGC/TATACC 3 -- ds50010--------
    rs1838564721,2
    		--23535840(+) GCTGCA/CAAAGA 3 -- ds50010--------
    rs1413549461,2
    		--23535850(+) ATGTGA/TTTTCA 3 -- ds50010--------
    rs795617571,2
    		F--23535873(+) GTTGCG/CTATGT 3 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1507979111,2
    		--23535879(+) TATGTA/GTTCCA 3 -- ds50010--------
    rs1886261031,2
    		--23535942(+) TCAGCC/TCATGA 3 -- ds50010--------
    rs70053681,2
    		C,F,A,H--23536098(+) CACCAT/CAGGTT 3 -- ds500124Minor allele frequency- C:0.11NS EA NA WA 2686
    rs1391689211,2
    		--23536166(+) GTTACA/GCAGCA 3 -- ds50010--------
    rs735449551,2
    		C--23536181(+) GTTTTC/TAGGAA 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1806788961,2
    		--23536225(+) ACATGA/GGTACT 3 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for NKX3-1 (23536206 - 23540450 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NKX3-1: --
    Human Gene Mutation Database (HGMD): NKX3-1

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing NKX3-1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKX3-1
    DNA2.0 Custom Variant and Variant Library Synthesis for NKX3-1

    Disorders / Diseases
    for NKX3-1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NKX3-1 for disorders           About GeneDecksing

    OMIM gene information: 602041    OMIM disorders: --

    19 diseases for NKX3-1:    About MalaCards
    prostatitis    urethral diverticulum    testicular germ cell tumor    germ cell tumor
    urethritis    acute lymphoblastic leukemia    lymphoblastic leukemia    ulcerative colitis
    prostate cancer    familial prostate cancer    prostate cancer, progression of    prostate carcinoma
    adenocarcinoma    atrophy of prostate    pharyngitis    leukemia
    carcinoma    hypoxia    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for NKX3-1:
    Prostate cancer

    10/11 Novoseek disease relationships for NKX3-1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 74.1 68 18360715 (6), 15734999 (6), 19263243 (3), 11137288 (3) (see all 23)
    prostatic intraepithelial neoplasia 58 4 11839815 (2), 17020998 (1), 15734999 (1)
    prostate carcinoma 54 7 9226374 (2), 16310933 (1), 11839815 (1), 16519150 (1) (see all 6)
    prostatic adenocarcinoma 37.1 1 15691383 (1)
    tumors 35.4 36 10688034 (6), 11839815 (3), 18360715 (3), 16310933 (2) (see all 14)
    benign prostatic hyperplasia 20.1 1 16519150 (1)
    cancer 19.6 4 9377551 (1), 11257711 (1), 15734999 (1), 16519150 (1)
    primary tumor 19.2 1 15691383 (1)
    metastasis 16.1 1 9377551 (1)
    adenocarcinoma 0 1 11836566 (1)

    Genetic Association Database (GAD): NKX3-1
    Human Genome Epidemiology (HuGE) Navigator: NKX3-1 (9 documents)

    Export disorders for NKX3-1 gene to outside databases

    Publications
    for NKX3-1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKX3-1 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with NKX3-1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. (PubMed id 9226374)1, 2, 3, 9 He W.-W.... Carter K.C. (1997)
    2. Full-length cDNA sequence and genomic organization of human NKX3A -- alternative mRNA forms and regulation by both androgens and estrogens. (PubMed id 11137288)1, 2, 9 Korkmaz K.S.... Saatcioglu F. (2000)
    3. Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1. (PubMed id 19462257)1, 2, 9 Zhang P....Jiang A. (2010)
    4. Isolation and androgen regulation of the human homeobox cDNA, NKX3.1. (PubMed id 9537602)1, 2, 9 Prescott J.L.... Tindall D.J. (1998)
    5. Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers. (PubMed id 9377551)1, 2, 9 Voeller H.J....Gelmann E.P. (1997)
    6. Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. (PubMed id 12972618)1, 2, 9 Hosohata K.... Wang Z. (2003)
    7. Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1. (PubMed id 18077445)1, 2 Guan B....Bieberich C.J. (2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function. (PubMed id 11980664)1, 4 Gelmann E.P....Stampfer M.J. (2002)
    10. NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. (PubMed id 11809674)1, 2 Chen H.... Bieberich C.J. (2002)

    External Searches for NKX3-1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NKX3-1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4824 HGNC: 7838 AceView: NKX3-1 Ensembl:ENSG00000167034 euGenes: HUgn4824
    ECgene: NKX3-1 Kegg: 4824 H-InvDB: NKX3-1

    Other Databases showing NKX3-1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NKX3-1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKX3-1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NKX3-1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NKX3-1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NKX3-1 gene:
    Search GeneIP for patents involving NKX3-1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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