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NKX3-1 Gene

protein-coding   GIFtS: 66
GCID: GC08M023536

NK3 Homeobox 1

(Previous names: NK homeobox (Drosophila), family 3, A, NK3 transcription...)
(Previous symbol: NKX3A)
  See NKX3-1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NK3 Homeobox 11 2     NK3 Transcription Factor Related, Locus 1 (Drosophila)1
NKX3A1 2 3 5     NKX32
Homeobox Protein NK-3 Homolog A2 3     Homeobox Protein Nkx-3.12
NKX3.12 3     NK Homeobox, Family 3, A2
BAPX22 5     NK3 Transcription Factor Homolog A2
NK Homeobox (Drosophila), Family 3, A1     NK3 Transcription Factor Related, Locus 12

External Ids:    HGNC: 78381   Entrez Gene: 48242   Ensembl: ENSG000001670347   OMIM: 6020415   UniProtKB: Q998013   
ORGUL members:         

Export aliases for NKX3-1 gene to outside databases

Previous GC identifers: GC08M023268 GC08M023889 GC08M023558 GC08M023592 GC08M022081


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NKX3-1 Gene:
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative
regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with
prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. (provided by
RefSeq, Jan 2012)

GeneCards Summary for NKX3-1 Gene:
NKX3-1 (NK3 homeobox 1) is a protein-coding gene. Diseases associated with NKX3-1 include chromosome 8p deletion, and familial prostate cancer. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

UniProtKB/Swiss-Prot: NKX31_HUMAN, Q99801
Function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave
as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation
of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling
prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3
prostate cancer cells

Gene Wiki entry for NKX3-1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKX3-1 gene promoter:
         SRF   p53   HTF   SRF (504 AA)   C/EBPalpha   PPAR-gamma1   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKX3-1 promoter sequence
   Search Chromatin IP Primers for NKX3-1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKX3-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

NKX3-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX3-1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M023536:  view genomic region     (about GC identifiers)

Start:
23,536,206 bp from pter      End:
23,540,450 bp from pter
Size:
4,245 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NKX31_HUMAN, Q99801 (See protein sequence)
Recommended Name: Homeobox protein Nkx-3.1  
Size: 234 amino acids; 26350 Da
Subunit: Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77.
Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation
1 PDB 3D structure from and Proteopedia for NKX3-1:
2L9R (3D)    
Secondary accessions: O15465 Q9H2P4 Q9H2P5 Q9H2P6 Q9H2P7 Q9HBG0
Alternative splicing: 5 isoforms:  Q99801-1   Q99801-2   Q99801-3   Q99801-4   Q99801-5   

Explore the universe of human proteins at neXtProt for NKX3-1: NX_Q99801

Explore proteomics data for NKX3-1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NKX3-1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243268.1  NP_006158.2  

    ENSEMBL proteins: 
     ENSP00000370253   ENSP00000429729  

    NKX3-1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for NKX3-1
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    Search eBioscience for ELISAs for NKX3-1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q99801

    ProtoNet protein and cluster: Q99801

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: NKX31_HUMAN, Q99801
    Similarity: Belongs to the NK-3 homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with NKX3-1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKX31_HUMAN, Q99801
    Function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave
    as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation
    of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling
    prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3
    prostate cancer cells
    Induction: By androgens and, in the LNCaP cell line, by estrogens. Androgenic control may be lost in prostate
    cancer cells during tumor progression from an androgen-dependent to an androgen-independent phase

         Gene Ontology (GO): Selected molecular function terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IDA--
    GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IEA--
    GO:0001047core promoter binding IDA18974119
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS11137288
         
    Find genes that share ontologies with NKX3-1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NKX3-1:
     Decreased mitotic index 

         11 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Nkx3-1):
     behavior/neurological  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     limbs/digits/tail  mortality/aging  no phenotypic analysis  reproductive system  skeleton 
     tumorigenesis 

    Find genes that share phenotypes with NKX3-1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NKX3-1: Nkx3-1Nkx3-tm1Siz Nkx3-1Nkx3-tm1.1Saa Nkx3-1Nkx3-tm1Mms

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKX3-1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKX3-1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NKX3-1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AAGCACTTAA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NKX3-1:
    hsa-mir-92a-3p (MIRT049849), hsa-mir-192-5p (MIRT026366), hsa-mir-215-5p (MIRT024883)

    Block miRNA regulation of human, mouse, rat NKX3-1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NKX3-1 (see all 39):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-488 hsa-miR-550a* hsa-miR-372 hsa-miR-3622b-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidNKX3-1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NKX3-1

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    Addgene plasmids for NKX3-1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NKX31_HUMAN, Q99801: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA19597465
    GO:0005634nucleus NAS11137288

    Find genes that share ontologies with NKX3-1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NKX3-1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glioma
    Prostate cancer0.39
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    3Pathways in cancer
    Pathways in cancer
    4FOXA1 transcription factor network
    FOXA1 transcription factor network
    5Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity


    Find genes that share SuperPaths with NKX3-1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NKX3-1
        SIDS Susceptibility Pathways
    FOXA1 transcription factor network
    Coregulation of Androgen receptor activity


    2 Kegg Pathways  (Kegg details for NKX3-1):
        Pathways in cancer
    Prostate cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NKX3-1: 
              Prostate Cancer in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NKX3-1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for NKX3-1 (Q998011, 3 ENSP000003702534) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOP1P113871, 3, ENSP000003545224EBI-1385894,EBI-876302 I2D: score=1 STRING: ENSP00000354522
    SP4Q024463, ENSP000002225844I2D: score=1 STRING: ENSP00000222584
    SP5Q6BEB43, ENSP000003644304I2D: score=1 STRING: ENSP00000364430
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    KAT2BQ928313, ENSP000002637544I2D: score=1 STRING: ENSP00000263754
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001655urogenital system development ----
    GO:0001656metanephros development IEA--
    GO:0001756somitogenesis IEA--
    GO:0001934positive regulation of protein phosphorylation IDA--
    GO:0006355regulation of transcription, DNA-templated NAS11137288

    Find genes that share ontologies with NKX3-1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NKX3-1 (NKX31)

    4 Novoseek inferred chemical compound relationships for NKX3-1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 44.8 10 10688034 (2), 19886863 (1), 11507036 (1), 19826044 (1) (see all 8)
    retinoic acid 30.3 4 16817226 (1), 17468839 (1)
    retinoid 28.9 4 16817226 (2)
    progesterone 0 1 11137288 (1)



    Find genes that share compounds with NKX3-1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NKX3-1 gene (2 alternative transcripts): 
    NM_001256339.1  NM_006167.3  

    Unigene Cluster for NKX3-1:

    NK3 homeobox 1
    Hs.55999  [show with all ESTs]
    Unigene Representative Sequence: NM_006167
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380871(uc011kzx.2) ENST00000523261
    miRNA
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    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-488 hsa-miR-550a* hsa-miR-372 hsa-miR-3622b-3p hsa-miR-3613-3p
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    Additional mRNA sequence: 

    AF247704.1 AF249669.1 AF249670.1 AF249671.1 AF249672.1 BC074863.2 BC074864.2 BC111569.1 
    BC111574.1 NR_046072.1 U80669.1 U91540.1 

    5 DOTS entries:

    DT.416292  DT.75129064  DT.100699282  DT.95156476  DT.95082017 

    Selected AceView cDNA sequences (see all 83):

    BC074863 BC074864 BX102941 AI989275 BF003027 AA442287 AA833543 BX641277 
    AI989281 AA813266 BU601144 BF514063 CF145380 W47380 CF138789 AI989272 
    BQ018482 AI685682 AF249671 AI748915 BF679599 BQ020946 AI672753 CF146489 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NKX3-1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTATTAG
    NKX3-1 Expression
    About this image


    NKX3-1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Somite (Muscoskeletal System)    fully expand to see all 10 entries
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Tendon & Ligament
             Sacral Sclerotome Cells Sacral Mesenchymal Sclerotome
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Sacral Sclerotome Cells Sacral Mesenchymal Sclerotome
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Sacral Sclerotome Cells Sacral Mesenchymal Sclerotome
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Hippocampus
    NKX3-1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NKX3-1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.55999

    UniProtKB/Swiss-Prot: NKX31_HUMAN, Q99801
    Tissue specificity: Highly expressed in the prostate and, at a lower level, in the testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NKX3-1: 
              Prostate Cancer in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NKX3-1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX3-1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NKX3-1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkx3-11 , 5 NK-3 transcription factor, locus 1 (Drosophila)1, 5 73.6(n)1
    68.58(a)1
      14 (36.02 cM)5
    180951  NM_010921.31  NP_035051.11 
     691906385 
    chicken
    (Gallus gallus)
    Aves NKX3-11 NK3 homeobox 1 60.93(n)
    56.99(a)
      101747314  XM_004947561.1  XP_004947618.1 
    lizard
    (Anolis carolinensis)
    Reptilia NKX3-16
    NK3 homeobox 1
    94(a)
    1 ↔ 1
    GL343754.1(164831-165016)
    African clawed frog
    (Xenopus laevis)
    Amphibia nkx3-1-prov2 NK3 transcription factor related, locus 1 (Drosophila) 79.64(n)    BC047968.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nkx3-11 NK3 homeobox 1 65.15(n)
    64.55(a)
      555375  XM_677868.4  XP_682960.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta bap6
    bagpipe
    21(a)
    1 → many
    3R(17214605-17216171)
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-276
    Protein CEH-27, isoform b (ceh-27) mRNA, complete ...
    19(a)
    many ↔ many
    V(11661553-11664697) WBGene00000449


    ENSEMBL Gene Tree for NKX3-1 (if available)
    TreeFam Gene Tree for NKX3-1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NKX3-1 gene
    NKX2-12  NKX6-12  HMX32  TLX22  TLX12  NKX2-32  HMX22  NKX6-32  
    NKX3-22  NKX6-22  NKX2-62  NKX2-82  NKX2-52  NKX2-22  NKX2-42  HMX12  
    TLX32  
    1 SIMAP similar gene for NKX3-1 using alignment to 1 protein entry:     NKX31_HUMAN:
    NKX2-6

    Find genes that share paralogs with NKX3-1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NKX3-1 (see all 157)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792765811,2
    --23535729(+) CTCTGC/TATACC 3 -- ds50010--------
    rs1838564721,2
    --23535840(+) GCTGCA/CAAAGA 3 -- ds50010--------
    rs1413549461,2
    --23535850(+) ATGTGA/TTTTCA 3 -- ds50010--------
    rs795617571,2
    C,F--23535873(+) GTTGCG/CTATGT 3 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1507979111,2
    --23535879(+) TATGTA/GTTCCA 3 -- ds50010--------
    rs1886261031,2
    --23535942(+) TCAGCC/TCATGA 3 -- ds50010--------
    rs70053681,2
    C,F,A,H--23536098(+) CACCAT/CAGGTT 3 -- ds500124Minor allele frequency- C:0.11NS EA NA WA 2686
    rs1391689211,2
    C--23536166(+) GTTACA/GCAGCA 3 -- ds50010--------
    rs735449551,2
    C,F--23536181(+) GTTTTC/TAGGAA 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1806788961,2
    --23536225(+) ACATGA/GGTACT 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for NKX3-1 (23536206 - 23540450 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NKX3-1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831269CNV Gain17160897

    Human Gene Mutation Database (HGMD): NKX3-1
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing NKX3-1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing NKX3-1
    DNA2.0 Custom Variant and Variant Library Synthesis for NKX3-1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602041    OMIM disorders: --

    3 diseases for NKX3-1:    
    About MalaCards
    chromosome 8p deletion    familial prostate cancer    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for NKX3-1:
    Prostate cancer

    Find genes that share disorders with NKX3-1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NKX3-1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 74.1 68 18360715 (6), 15734999 (6), 19263243 (3), 11137288 (3) (see all 23)
    prostatic intraepithelial neoplasia 58 4 11839815 (2), 17020998 (1), 15734999 (1)
    prostate carcinoma 54 7 9226374 (2), 16310933 (1), 11839815 (1), 16519150 (1) (see all 6)
    prostatic adenocarcinoma 37.1 1 15691383 (1)
    tumors 35.4 36 10688034 (6), 11839815 (3), 18360715 (3), 16310933 (2) (see all 14)
    benign prostatic hyperplasia 20.1 1 16519150 (1)
    cancer 19.6 4 9377551 (1), 11257711 (1), 15734999 (1), 16519150 (1)
    primary tumor 19.2 1 15691383 (1)
    metastasis 16.1 1 9377551 (1)
    adenocarcinoma 0 1 11836566 (1)

    Genetic Association Database (GAD): NKX3-1
    Human Genome Epidemiology (HuGE) Navigator: NKX3-1 (9 documents)

    Export disorders for NKX3-1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKX3-1 gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with NKX3-1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. (PubMed id 9226374)1, 2, 3, 9 He W.-W.... Carter K.C. (Genomics 1997)
    2. Full-length cDNA sequence and genomic organization of human NKX3A -- alternative mRNA forms and regulation by both androgens and estrogens. (PubMed id 11137288)1, 2, 9 Korkmaz K.S.... Saatcioglu F. (Gene 2000)
    3. Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1. (PubMed id 19462257)1, 2, 9 Zhang P....Jiang A. (Mol. Biol. Rep. 2010)
    4. Isolation and androgen regulation of the human homeobox cDNA, NKX3.1. (PubMed id 9537602)1, 2, 9 Prescott J.L.... Tindall D.J. (Prostate 1998)
    5. Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers. (PubMed id 9377551)1, 2, 9 Voeller H.J....Gelmann E.P. (Cancer Res. 1997)
    6. Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. (PubMed id 12972618)1, 2, 9 Hosohata K.... Wang Z. (Mol. Cell. Biol. 2003)
    7. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PubMed id 20564319)1, 4 Kim S.T....Sun J. (Prostate 2010)
    8. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. (PubMed id 19767753)1, 4 Eeles R.A....Easton D.F. (Nat. Genet. 2009)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    10. Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1. (PubMed id 18077445)1, 2 Guan B....Bieberich C.J. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4824 HGNC: 7838 AceView: NKX3-1 Ensembl:ENSG00000167034 euGenes: HUgn4824
    ECgene: NKX3-1 Kegg: 4824 H-InvDB: NKX3-1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NKX3-1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NKX3-1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NKX3-1 gene:
    Search GeneIP for patents involving NKX3-1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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