Aliases for NKX3-1 Gene
External Ids for NKX3-1 Gene
Previous HGNC Symbols for NKX3-1 Gene
Previous GeneCards Identifiers for NKX3-1 Gene
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for NKX3-1 Gene
NKX3-1 (NK3 Homeobox 1) is a Protein Coding gene. Diseases associated with NKX3-1 include chromosome 8p deletion and urethral diverticulum. Among its related pathways are Pathways in cancer and Glioma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is NKX2-5.
UniProtKB/Swiss-Prot for NKX3-1 Gene
Transcription factor, which binds preferentially the consensus sequence 5-TAAGT[AG]-3 and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.