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Aliases for NKX3-1 Gene

Aliases for NKX3-1 Gene

  • NK3 Homeobox 1 2 3
  • NKX3A 3 4 6
  • Homeobox Protein NK-3 Homolog A 3 4
  • NKX3.1 3 4
  • BAPX2 3 6
  • NK3 Transcription Factor Related, Locus 1 (Drosophila) 2
  • NK3 Transcription Factor Related, Locus 1 3
  • NK Homeobox (Drosophila), Family 3, A 2
  • NK3 Transcription Factor Homolog A 3
  • NK Homeobox, Family 3, A 3
  • Homeobox Protein Nkx-3.1 3
  • NKX3 3

External Ids for NKX3-1 Gene

Previous HGNC Symbols for NKX3-1 Gene

  • NKX3A

Previous GeneCards Identifiers for NKX3-1 Gene

  • GC08M023268
  • GC08M023889
  • GC08M023558
  • GC08M023592
  • GC08M022081
  • GC08M023536

Summaries for NKX3-1 Gene

Entrez Gene Summary for NKX3-1 Gene

  • This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for NKX3-1 Gene

NKX3-1 (NK3 Homeobox 1) is a Protein Coding gene. Diseases associated with NKX3-1 include chromosome 8p deletion and prostate cancer. Among its related pathways are Pathways in cancer and Glioma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is NKX2-5.

UniProtKB/Swiss-Prot for NKX3-1 Gene

  • Transcription factor, which binds preferentially the consensus sequence 5-TAAGT[AG]-3 and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Gene Wiki entry for NKX3-1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX3-1 Gene

Genomics for NKX3-1 Gene

Regulatory Elements for NKX3-1 Gene

Genomic Location for NKX3-1 Gene

Start:
23,678,693 bp from pter
End:
23,682,937 bp from pter
Size:
4,245 bases
Orientation:
Minus strand

Genomic View for NKX3-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKX3-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX3-1 Gene

Proteins for NKX3-1 Gene

  • Protein details for NKX3-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99801-NKX31_HUMAN
    Recommended name:
    Homeobox protein Nkx-3.1
    Protein Accession:
    Q99801
    Secondary Accessions:
    • O15465
    • Q9H2P4
    • Q9H2P5
    • Q9H2P6
    • Q9H2P7
    • Q9HBG0

    Protein attributes for NKX3-1 Gene

    Size:
    234 amino acids
    Molecular mass:
    26350 Da
    Quaternary structure:
    • Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation.

    Three dimensional structures from OCA and Proteopedia for NKX3-1 Gene

    Alternative splice isoforms for NKX3-1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKX3-1 Gene

Proteomics data for NKX3-1 Gene at MOPED

Post-translational modifications for NKX3-1 Gene

  • Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKX3-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NKX3-1 Gene

Domains for NKX3-1 Gene

Gene Families for NKX3-1 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Suggested Antigen Peptide Sequences for NKX3-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99801

UniProtKB/Swiss-Prot:

NKX31_HUMAN :
  • Q99801
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the NK-3 homeobox family.
genes like me logo Genes that share domains with NKX3-1: view

Function for NKX3-1 Gene

Molecular function for NKX3-1 Gene

UniProtKB/Swiss-Prot Function: Transcription factor, which binds preferentially the consensus sequence 5-TAAGT[AG]-3 and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
UniProtKB/Swiss-Prot Induction: By androgens and, in the LNCaP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen-independent phase.

Gene Ontology (GO) - Molecular Function for NKX3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 20855495
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IEA --
GO:0001047 core promoter binding IDA 18974119
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 11137288
genes like me logo Genes that share ontologies with NKX3-1: view
genes like me logo Genes that share phenotypes with NKX3-1: view

Animal Models for NKX3-1 Gene

MGI Knock Outs for NKX3-1:

Animal Model Products

CRISPR Products

miRNA for NKX3-1 Gene

miRTarBase miRNAs that target NKX3-1
Targeting motifs for NKX3-1 Gene
HOMER Transcription Factor Regulatory Elements motif NKX3-1
  • Consensus sequence: AAGCACTTAA Submotif: canonical Cell Type: LNCaP GeoId: GSE28264

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NKX3-1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for NKX3-1 Gene

Localization for NKX3-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX3-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKX3-1 Gene COMPARTMENTS Subcellular localization image for NKX3-1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NKX3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 19597465
GO:0005634 nucleus NAS 11137288
genes like me logo Genes that share ontologies with NKX3-1: view

Pathways for NKX3-1 Gene

genes like me logo Genes that share pathways with NKX3-1: view

Pathways by source for NKX3-1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for NKX3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development --
GO:0001656 metanephros development IEA --
GO:0001756 somitogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 20395202
GO:0006355 regulation of transcription, DNA-templated NAS 11137288
genes like me logo Genes that share ontologies with NKX3-1: view

Compounds for NKX3-1 Gene

(4) Novoseek inferred chemical compound relationships for NKX3-1 Gene

Compound -log(P) Hits PubMed IDs
testosterone 44.8 9
retinoic acid 30.3 2
retinoid 28.9 2
progesterone 0 1
genes like me logo Genes that share compounds with NKX3-1: view

Transcripts for NKX3-1 Gene

mRNA/cDNA for NKX3-1 Gene

Unigene Clusters for NKX3-1 Gene

NK3 homeobox 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NKX3-1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKX3-1 Gene

No ASD Table

Relevant External Links for NKX3-1 Gene

GeneLoc Exon Structure for
NKX3-1
ECgene alternative splicing isoforms for
NKX3-1

Expression for NKX3-1 Gene

mRNA expression in normal human tissues for NKX3-1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKX3-1 Gene

This gene is overexpressed in Prostate (29.4) and Minor Salivary Gland (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NKX3-1 Gene

SOURCE GeneReport for Unigene cluster for NKX3-1 Gene Hs.55999

mRNA Expression by UniProt/SwissProt for NKX3-1 Gene

Q99801-NKX31_HUMAN
Tissue specificity: Highly expressed in the prostate and, at a lower level, in the testis.
genes like me logo Genes that share expressions with NKX3-1: view

In Situ Assay Products

Orthologs for NKX3-1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX3-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKX3-1 35
  • 99.3 (n)
  • 97.89 (a)
NKX3-1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKX3-1 35
  • 80.48 (n)
  • 74.79 (a)
NKX3-1 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKX3-1 35
  • 87.86 (n)
  • 84.29 (a)
NKX3-1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkx3-1 35
  • 73.6 (n)
  • 68.58 (a)
Nkx3-1 16
Nkx3-1 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKX3-1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKX3-1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkx3-1 35
  • 72.15 (n)
  • 65.8 (a)
chicken
(Gallus gallus)
Aves NKX3-1 35
  • 60.93 (n)
  • 56.99 (a)
SOHO-1 36
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NKX3-1 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nkx3-1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nkx3-1 35
  • 56.68 (n)
  • 51.27 (a)
Str.5202 35
zebrafish
(Danio rerio)
Actinopterygii nkx3-1 35
  • 65.15 (n)
  • 64.55 (a)
nkx3-1 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bap 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-27 36
  • 19 (a)
ManyToMany
Species with no ortholog for NKX3-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKX3-1 Gene

ENSEMBL:
Gene Tree for NKX3-1 (if available)
TreeFam:
Gene Tree for NKX3-1 (if available)

Paralogs for NKX3-1 Gene

Selected SIMAP similar genes for NKX3-1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX3-1: view

Variants for NKX3-1 Gene

Sequence variations from dbSNP and Humsavar for NKX3-1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs13116 -- 23,678,925(+) ACCTG(C/T)CAGAT utr-variant-3-prime, nc-transcript-variant
rs1567669 -- 23,681,020(-) ATTCC(C/T)CCAGT utr-variant-3-prime, nc-transcript-variant
rs2228013 - 23,682,736(-) GACAG(C/T)GCGAC intron-variant, reference, missense
rs3840700 -- 23,683,384(-) GAGAG(-/AG)CACCC upstream-variant-2KB
rs4872176 -- 23,680,495(+) GGCCC(A/C/T)CCCTC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NKX3-1 Gene

Variant ID Type Subtype PubMed ID
nsv831269 CNV Gain 17160897

Relevant External Links for NKX3-1 Gene

HapMap Linkage Disequilibrium report
NKX3-1
Human Gene Mutation Database (HGMD)
NKX3-1

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX3-1 Gene

Disorders for NKX3-1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NKX3-1 Gene including...

Search for NKX3-1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NKX3-1 Gene

(11) Novoseek inferred disease relationships for NKX3-1 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 74.1 54
prostatic intraepithelial neoplasia 58 4
prostate carcinoma 54 7
prostatic adenocarcinoma 37.1 1
tumors 35.4 26

Relevant External Links for NKX3-1

Genetic Association Database (GAD)
NKX3-1
Human Genome Epidemiology (HuGE) Navigator
NKX3-1
genes like me logo Genes that share disorders with NKX3-1: view

No data available for UniProtKB/Swiss-Prot for NKX3-1 Gene

Publications for NKX3-1 Gene

  1. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. (PMID: 9226374) He W.-W. … Carter K.C. (Genomics 1997) 2 3 4 23
  2. Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers. (PMID: 9377551) Voeller H.J. … Gelmann E.P. (Cancer Res. 1997) 3 4 23
  3. Isolation and androgen regulation of the human homeobox cDNA, NKX3.1. (PMID: 9537602) Prescott J.L. … Tindall D.J. (Prostate 1998) 3 4 23
  4. Full-length cDNA sequence and genomic organization of human NKX3A -- alternative mRNA forms and regulation by both androgens and estrogens. (PMID: 11137288) Korkmaz K.S. … Saatcioglu F. (Gene 2000) 3 4 23
  5. Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. (PMID: 12972618) Hosohata K. … Wang Z. (Mol. Cell. Biol. 2003) 3 4 23

Products for NKX3-1 Gene

Sources for NKX3-1 Gene

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