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Aliases for NKX3-1 Gene

Aliases for NKX3-1 Gene

  • NK3 Homeobox 1 2 3
  • Homeobox Protein NK-3 Homolog A 3 4
  • NKX3.1 3 4
  • NKX3A 3 4
  • NK3 Transcription Factor Related, Locus 1 (Drosophila) 2
  • NK3 Transcription Factor Related, Locus 1 3
  • NK Homeobox (Drosophila), Family 3, A 2
  • NK3 Transcription Factor Homolog A 3
  • NK Homeobox, Family 3, A 3
  • BAPX2 3
  • NKX3 3

External Ids for NKX3-1 Gene

Previous HGNC Symbols for NKX3-1 Gene

  • NKX3A

Previous GeneCards Identifiers for NKX3-1 Gene

  • GC08M023268
  • GC08M023889
  • GC08M023558
  • GC08M023592
  • GC08M022081
  • GC08M023536

Summaries for NKX3-1 Gene

Entrez Gene Summary for NKX3-1 Gene

  • This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for NKX3-1 Gene

NKX3-1 (NK3 Homeobox 1) is a Protein Coding gene. Diseases associated with NKX3-1 include chromosome 8p deletion and urethral diverticulum. Among its related pathways are Pathways in cancer and Glioma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is NKX2-5.

UniProtKB/Swiss-Prot for NKX3-1 Gene

  • Transcription factor, which binds preferentially the consensus sequence 5-TAAGT[AG]-3 and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Gene Wiki entry for NKX3-1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX3-1 Gene

Genomics for NKX3-1 Gene

Regulatory Elements for NKX3-1 Gene

Genomic Location for NKX3-1 Gene

Chromosome:
8
Start:
23,678,693 bp from pter
End:
23,682,937 bp from pter
Size:
4,245 bases
Orientation:
Minus strand

Genomic View for NKX3-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKX3-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX3-1 Gene

Proteins for NKX3-1 Gene

  • Protein details for NKX3-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99801-NKX31_HUMAN
    Recommended name:
    Homeobox protein Nkx-3.1
    Protein Accession:
    Q99801
    Secondary Accessions:
    • O15465
    • Q9H2P4
    • Q9H2P5
    • Q9H2P6
    • Q9H2P7
    • Q9HBG0

    Protein attributes for NKX3-1 Gene

    Size:
    234 amino acids
    Molecular mass:
    26350 Da
    Quaternary structure:
    • Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation.

    Three dimensional structures from OCA and Proteopedia for NKX3-1 Gene

    Alternative splice isoforms for NKX3-1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKX3-1 Gene

Proteomics data for NKX3-1 Gene at MOPED

Post-translational modifications for NKX3-1 Gene

  • Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKX3-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX3-1 Gene

Domains & Families for NKX3-1 Gene

Gene Families for NKX3-1 Gene

Suggested Antigen Peptide Sequences for NKX3-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99801

UniProtKB/Swiss-Prot:

NKX31_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the NK-3 homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the NK-3 homeobox family.
genes like me logo Genes that share domains with NKX3-1: view

Function for NKX3-1 Gene

Molecular function for NKX3-1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor, which binds preferentially the consensus sequence 5-TAAGT[AG]-3 and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
UniProtKB/Swiss-Prot Induction:
By androgens and, in the LNCaP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen-independent phase.

Gene Ontology (GO) - Molecular Function for NKX3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 20855495
GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific IEA --
GO:0001047 core promoter binding IDA 18974119
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 11137288
genes like me logo Genes that share ontologies with NKX3-1: view
genes like me logo Genes that share phenotypes with NKX3-1: view

Animal Models for NKX3-1 Gene

MGI Knock Outs for NKX3-1:

Animal Model Products

CRISPR Products

miRNA for NKX3-1 Gene

Transcription Factor Targets for NKX3-1 Gene

Selected GeneGlobe predicted Target genes for NKX3-1
Targeted motifs for NKX3-1 Gene
HOMER Transcription Factor Regulatory Elements motif NKX3-1
  • Consensus sequence: AAGCACTTAA Submotif: canonical Cell Type: LNCaP GEO ID: GSE28264

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NKX3-1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for NKX3-1 Gene

Localization for NKX3-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX3-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKX3-1 Gene COMPARTMENTS Subcellular localization image for NKX3-1 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NKX3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 19597465
GO:0005634 nucleus NAS 11137288
genes like me logo Genes that share ontologies with NKX3-1: view

Pathways & Interactions for NKX3-1 Gene

genes like me logo Genes that share pathways with NKX3-1: view

Pathways by source for NKX3-1 Gene

PCR Array Products

SIGNOR curated interactions for NKX3-1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NKX3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development --
GO:0001656 metanephros development IEA --
GO:0001756 somitogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 20395202
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with NKX3-1: view

Drugs & Compounds for NKX3-1 Gene

(2) Drugs for NKX3-1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453

(2) Additional Compounds for NKX3-1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
302-79-4
Retinoid
genes like me logo Genes that share compounds with NKX3-1: view

Transcripts for NKX3-1 Gene

mRNA/cDNA for NKX3-1 Gene

Unigene Clusters for NKX3-1 Gene

NK3 homeobox 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NKX3-1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKX3-1 Gene

No ASD Table

Relevant External Links for NKX3-1 Gene

GeneLoc Exon Structure for
NKX3-1
ECgene alternative splicing isoforms for
NKX3-1

Expression for NKX3-1 Gene

mRNA expression in normal human tissues for NKX3-1 Gene

mRNA differential expression in normal tissues according to GTEx for NKX3-1 Gene

This gene is overexpressed in Prostate (x29.4) and Minor Salivary Gland (x7.0).

Protein differential expression in normal tissues from HIPED for NKX3-1 Gene

This gene is overexpressed in Heart (43.8) and Prostate (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NKX3-1 Gene



SOURCE GeneReport for Unigene cluster for NKX3-1 Gene Hs.55999

mRNA Expression by UniProt/SwissProt for NKX3-1 Gene

Q99801-NKX31_HUMAN
Tissue specificity: Highly expressed in the prostate and, at a lower level, in the testis.
genes like me logo Genes that share expression patterns with NKX3-1: view

Protein tissue co-expression partners for NKX3-1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NKX3-1 Gene

Orthologs for NKX3-1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX3-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NKX3-1 35
  • 80.48 (n)
  • 74.79 (a)
NKX3-1 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKX3-1 35
  • 87.86 (n)
  • 84.29 (a)
NKX3-1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkx3-1 35
  • 73.6 (n)
  • 68.58 (a)
Nkx3-1 16
Nkx3-1 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NKX3-1 35
  • 99.3 (n)
  • 97.89 (a)
NKX3-1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkx3-1 35
  • 72.15 (n)
  • 65.8 (a)
oppossum
(Monodelphis domestica)
Mammalia NKX3-1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKX3-1 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKX3-1 35
  • 60.93 (n)
  • 56.99 (a)
SOHO-1 36
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NKX3-1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkx3-1 35
  • 56.68 (n)
  • 51.27 (a)
Str.5202 35
African clawed frog
(Xenopus laevis)
Amphibia nkx3-1-prov 35
zebrafish
(Danio rerio)
Actinopterygii nkx3-1 35
  • 65.15 (n)
  • 64.55 (a)
nkx3-1 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bap 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-27 36
  • 19 (a)
ManyToMany
Species with no ortholog for NKX3-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKX3-1 Gene

ENSEMBL:
Gene Tree for NKX3-1 (if available)
TreeFam:
Gene Tree for NKX3-1 (if available)

Paralogs for NKX3-1 Gene

(1) SIMAP similar genes for NKX3-1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX3-1: view

Variants for NKX3-1 Gene

Sequence variations from dbSNP and Humsavar for NKX3-1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs13116 -- 23,678,925(+) ACCTG(C/T)CAGAT utr-variant-3-prime, nc-transcript-variant
rs1567669 -- 23,681,020(-) ATTCC(C/T)CCAGT utr-variant-3-prime, nc-transcript-variant
rs2228013 - 23,682,736(-) GACAG(C/T)GCGAC intron-variant, reference, missense
rs3840700 -- 23,683,384(-) GAGAG(-/AG/AGAG)CACCC upstream-variant-2KB
rs4872176 -- 23,680,495(+) GGCCC(A/C/T)CCCTC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NKX3-1 Gene

Variant ID Type Subtype PubMed ID
nsv831269 CNV Gain 17160897

Variation tolerance for NKX3-1 Gene

Residual Variation Intolerance Score: 60.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKX3-1 Gene

HapMap Linkage Disequilibrium report
NKX3-1
Human Gene Mutation Database (HGMD)
NKX3-1

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX3-1 Gene

Disorders for NKX3-1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for NKX3-1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
chromosome 8p deletion
  • 8p deletion
urethral diverticulum
prostate sarcoma
  • sarcoma of the prostate
prostatitis
male reproductive organ cancer
  • malignant neoplasm of male genital organ, unspecified
- elite association

Relevant External Links for NKX3-1

Genetic Association Database (GAD)
NKX3-1
Human Genome Epidemiology (HuGE) Navigator
NKX3-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKX3-1
genes like me logo Genes that share disorders with NKX3-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NKX3-1 Gene

Publications for NKX3-1 Gene

  1. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. (PMID: 9226374) He W.-W. … Carter K.C. (Genomics 1997) 2 23 67
  2. Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1. (PMID: 19462257) Zhang P. … Jiang A. (Mol. Biol. Rep. 2010) 23 67
  3. Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region. (PMID: 19886863) Thomas M.A. … Bentel J.M. (Biochem. J. 2010) 23 67
  4. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. (PMID: 20479932) Kunderfranco P. … Carbone G.M. (PLoS ONE 2010) 23 67
  5. Functional remodeling of benign human prostatic tissues in vivo by spontaneously immortalized progenitor and intermediate cells. (PMID: 20020426) Jiang M. … Hayward S.W. (Stem Cells 2010) 23 67

Products for NKX3-1 Gene

Sources for NKX3-1 Gene

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