Aliases for NKX2-8 Gene
External Ids for NKX2-8 Gene
Previous HGNC Symbols for NKX2-8 Gene
Previous GeneCards Identifiers for NKX2-8 Gene
The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]
GeneCards Summary for NKX2-8 Gene
NKX2-8 (NK2 Homeobox 8) is a Protein Coding gene. Diseases associated with NKX2-8 include Tethered Spinal Cord Syndrome and Neural Tube Defects. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NKX2-2.