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Aliases for NKX2-8 Gene

Aliases for NKX2-8 Gene

  • NK2 Homeobox 8 2 3 5
  • Homeobox Protein NK-2 Homolog H 3 4
  • NKX2H 3 4
  • NK2 Transcription Factor Related, Locus 8 (Drosophila) 2
  • NK2 Transcription Factor Related, Locus 8 3
  • NK-2 Homolog H (Drosophila) 2
  • NK-2 Homolog 8 3
  • NK-2 Homolog H 3
  • NKX-2.8 4
  • NKX2.8 3
  • Nkx2-9 3
  • NKX2G 4

External Ids for NKX2-8 Gene

Previous HGNC Symbols for NKX2-8 Gene

  • NKX2H

Previous GeneCards Identifiers for NKX2-8 Gene

  • GC14M034430
  • GC14M030907
  • GC14M035039
  • GC14M036118
  • GC14M037049
  • GC14M017163

Summaries for NKX2-8 Gene

Entrez Gene Summary for NKX2-8 Gene

  • The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]

GeneCards Summary for NKX2-8 Gene

NKX2-8 (NK2 Homeobox 8) is a Protein Coding gene. Diseases associated with NKX2-8 include tethered spinal cord syndrome and neural tube defects. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is DLX5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX2-8 Gene

Genomics for NKX2-8 Gene

Regulatory Elements for NKX2-8 Gene

Promoters for NKX2-8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NKX2-8 on UCSC Golden Path with GeneCards custom track

Genomic Location for NKX2-8 Gene

Chromosome:
14
Start:
36,580,011 bp from pter
End:
36,582,607 bp from pter
Size:
2,597 bases
Orientation:
Minus strand

Genomic View for NKX2-8 Gene

Genes around NKX2-8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKX2-8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKX2-8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX2-8 Gene

Proteins for NKX2-8 Gene

  • Protein details for NKX2-8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15522-NKX28_HUMAN
    Recommended name:
    Homeobox protein Nkx-2.8
    Protein Accession:
    O15522
    Secondary Accessions:
    • Q8IUT7

    Protein attributes for NKX2-8 Gene

    Size:
    239 amino acids
    Molecular mass:
    25866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKX2-8 Gene

Proteomics data for NKX2-8 Gene at MOPED

Post-translational modifications for NKX2-8 Gene

No Post-translational modifications

Other Protein References for NKX2-8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX2-8 Gene

Domains & Families for NKX2-8 Gene

Gene Families for NKX2-8 Gene

Protein Domains for NKX2-8 Gene

Suggested Antigen Peptide Sequences for NKX2-8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15522

UniProtKB/Swiss-Prot:

NKX28_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the NK-2 homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the NK-2 homeobox family.
genes like me logo Genes that share domains with NKX2-8: view

Function for NKX2-8 Gene

Gene Ontology (GO) - Molecular Function for NKX2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 12167706
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NKX2-8: view
genes like me logo Genes that share phenotypes with NKX2-8: view

Animal Models for NKX2-8 Gene

MGI Knock Outs for NKX2-8:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKX2-8 Gene

Localization for NKX2-8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX2-8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKX2-8 Gene COMPARTMENTS Subcellular localization image for NKX2-8 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for NKX2-8 Gene

Pathways & Interactions for NKX2-8 Gene

SuperPathways for NKX2-8 Gene

No Data Available

Interacting Proteins for NKX2-8 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258829%0d%0a9606.ENSP00000354487%0d%0a9606.ENSP00000261454%0d%0a9606.ENSP00000405932%0d%0a
Selected Interacting proteins: ENSP00000258829 for NKX2-8 Gene via STRING

Gene Ontology (GO) - Biological Process for NKX2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IDA 9446603
GO:0007409 axonogenesis IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12167706
genes like me logo Genes that share ontologies with NKX2-8: view

No data available for Pathways by source and SIGNOR curated interactions for NKX2-8 Gene

Drugs & Compounds for NKX2-8 Gene

No Compound Related Data Available

Transcripts for NKX2-8 Gene

mRNA/cDNA for NKX2-8 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKX2-8 Gene

NK2 homeobox 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKX2-8 Gene

No ASD Table

Relevant External Links for NKX2-8 Gene

GeneLoc Exon Structure for
NKX2-8
ECgene alternative splicing isoforms for
NKX2-8

Expression for NKX2-8 Gene

mRNA expression in normal human tissues for NKX2-8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKX2-8 Gene

This gene is overexpressed in Testis (x19.2), Brain - Spinal cord (cervical c-1) (x9.7), and Esophagus - Mucosa (x6.1).

Protein differential expression in normal tissues from HIPED for NKX2-8 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NKX2-8 Gene



SOURCE GeneReport for Unigene cluster for NKX2-8 Gene Hs.234763

genes like me logo Genes that share expression patterns with NKX2-8: view

Protein tissue co-expression partners for NKX2-8 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NKX2-8 Gene

Orthologs for NKX2-8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX2-8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NKX2-8 35
  • 87.9 (n)
  • 87.76 (a)
NKX2-8 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKX2-8 35
  • 86.86 (n)
  • 88.56 (a)
NKX2-8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkx2-9 35
  • 79.15 (n)
  • 77.02 (a)
Nkx2-9 16
Nkx2-9 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NKX2-8 35
  • 99.58 (n)
  • 99.16 (a)
NKX2-8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkx2-8 35
  • 79.97 (n)
  • 79.4 (a)
oppossum
(Monodelphis domestica)
Mammalia NKX2-8 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKX2-8 35
  • 68 (n)
  • 62.22 (a)
NKX2-8 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkx2-8 35
  • 53.88 (n)
  • 52.43 (a)
zebrafish
(Danio rerio)
Actinopterygii nkx2.9 35
  • 60.84 (n)
  • 64.34 (a)
nkx2.2b 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta vnd 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-22 36
  • 21 (a)
OneToMany
Species with no ortholog for NKX2-8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKX2-8 Gene

ENSEMBL:
Gene Tree for NKX2-8 (if available)
TreeFam:
Gene Tree for NKX2-8 (if available)

Paralogs for NKX2-8 Gene

(4) SIMAP similar genes for NKX2-8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX2-8: view

Variants for NKX2-8 Gene

Sequence variations from dbSNP and Humsavar for NKX2-8 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_003753 -

Structural Variations from Database of Genomic Variants (DGV) for NKX2-8 Gene

Variant ID Type Subtype PubMed ID
esv32575 CNV Gain 17666407

Variation tolerance for NKX2-8 Gene

Gene Damage Index Score: 2.25; 40.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKX2-8 Gene

HapMap Linkage Disequilibrium report
NKX2-8
Human Gene Mutation Database (HGMD)
NKX2-8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX2-8 Gene

Disorders for NKX2-8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NKX2-8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tethered spinal cord syndrome
  • spinal dysraphism
neural tube defects
  • spina bifida
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NKX2-8

Genetic Association Database (GAD)
NKX2-8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKX2-8
genes like me logo Genes that share disorders with NKX2-8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NKX2-8 Gene

Publications for NKX2-8 Gene

  1. A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma. (PMID: 9446603) Apergis G.A. … Locker J. (J. Biol. Chem. 1998) 2 3 4 67
  2. Regulation of alpha-fetoprotein expression by Nkx2.8. (PMID: 12167706) Kajiyama Y. … Locker J. (Mol. Cell. Biol. 2002) 3 23
  3. Nkx2-8 downregulation promotes angiogenesis and activates NF-I_B in esophageal cancer. (PMID: 23604637) Lin C. … Li J. (Cancer Res. 2013) 3
  4. Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans. (PMID: 23874236) Safra N. … Bannasch D.L. (PLoS Genet. 2013) 3
  5. The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway. (PMID: 22223847) Yu C. … Song L. (Carcinogenesis 2012) 3

Products for NKX2-8 Gene

Sources for NKX2-8 Gene

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