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Aliases for NKX2-8 Gene

Aliases for NKX2-8 Gene

  • NK2 Homeobox 8 2 3
  • Homeobox Protein NK-2 Homolog H 3 4
  • NKX2H 3 4
  • NK2 Transcription Factor Related, Locus 8 (Drosophila) 2
  • NK2 Transcription Factor Related, Locus 8 3
  • NK-2 Homolog H (Drosophila) 2
  • NK-2 Homolog 8 3
  • NK-2 Homolog H 3
  • NKX-2.8 4
  • NKX2.8 3
  • Nkx2-9 3
  • NKX2G 4

External Ids for NKX2-8 Gene

Previous HGNC Symbols for NKX2-8 Gene

  • NKX2H

Previous GeneCards Identifiers for NKX2-8 Gene

  • GC14M034430
  • GC14M030907
  • GC14M035039
  • GC14M036118
  • GC14M037049
  • GC14M017163

Summaries for NKX2-8 Gene

GeneCards Summary for NKX2-8 Gene

NKX2-8 (NK2 Homeobox 8) is a Protein Coding gene. Diseases associated with NKX2-8 include tethered spinal cord syndrome. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NKX2-5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX2-8 Gene

Genomics for NKX2-8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NKX2-8 Gene

Chromosome:
14
Start:
36,580,011 bp from pter
End:
36,582,607 bp from pter
Size:
2,597 bases
Orientation:
Minus strand

Genomic View for NKX2-8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for NKX2-8 Gene

Proteins for NKX2-8 Gene

  • Protein details for NKX2-8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15522-NKX28_HUMAN
    Recommended name:
    Homeobox protein Nkx-2.8
    Protein Accession:
    O15522
    Secondary Accessions:
    • Q8IUT7

    Protein attributes for NKX2-8 Gene

    Size:
    239 amino acids
    Molecular mass:
    25866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKX2-8 Gene

Proteomics data for NKX2-8 Gene at MOPED

Post-translational modifications for NKX2-8 Gene

No Post-translational modifications

Other Protein References for NKX2-8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX2-8 Gene

Domains & Families for NKX2-8 Gene

Gene Families for NKX2-8 Gene

Protein Domains for NKX2-8 Gene

Suggested Antigen Peptide Sequences for NKX2-8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15522

UniProtKB/Swiss-Prot:

NKX28_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the NK-2 homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the NK-2 homeobox family.
genes like me logo Genes that share domains with NKX2-8: view

Function for NKX2-8 Gene

Gene Ontology (GO) - Molecular Function for NKX2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12167706
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 12167706
GO:0003677 DNA binding --
GO:0003690 double-stranded DNA binding IDA 9446603
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 9446603
genes like me logo Genes that share ontologies with NKX2-8: view

Phenotypes for NKX2-8 Gene

genes like me logo Genes that share phenotypes with NKX2-8: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NKX2-8 Gene

Localization for NKX2-8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX2-8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKX2-8 Gene COMPARTMENTS Subcellular localization image for NKX2-8 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for NKX2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NKX2-8: view

Pathways & Interactions for NKX2-8 Gene

SuperPathways for NKX2-8 Gene

No Data Available

Interacting Proteins for NKX2-8 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258829%0d%0a9606.ENSP00000354487%0d%0a9606.ENSP00000261454%0d%0a9606.ENSP00000405932%0d%0a
Selected Interacting proteins: ENSP00000258829 for NKX2-8 Gene via STRING

Gene Ontology (GO) - Biological Process for NKX2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development NAS 9446603
GO:0006351 transcription, DNA-templated IDA 9446603
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IDA 9446603
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with NKX2-8: view

No data available for Pathways by source and SIGNOR curated interactions for NKX2-8 Gene

Drugs & Compounds for NKX2-8 Gene

No Compound Related Data Available

Transcripts for NKX2-8 Gene

mRNA/cDNA for NKX2-8 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKX2-8 Gene

NK2 homeobox 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKX2-8 Gene

No ASD Table

Relevant External Links for NKX2-8 Gene

GeneLoc Exon Structure for
NKX2-8
ECgene alternative splicing isoforms for
NKX2-8

Expression for NKX2-8 Gene

mRNA expression in normal human tissues for NKX2-8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKX2-8 Gene

This gene is overexpressed in Testis (x19.2), Brain - Spinal cord (cervical c-1) (x9.7), and Esophagus - Mucosa (x6.1).

Protein differential expression in normal tissues from HIPED for NKX2-8 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NKX2-8 Gene



SOURCE GeneReport for Unigene cluster for NKX2-8 Gene Hs.234763

genes like me logo Genes that share expression patterns with NKX2-8: view

Protein tissue co-expression partners for NKX2-8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NKX2-8 Gene

Orthologs for NKX2-8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX2-8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NKX2-8 35
  • 87.9 (n)
  • 87.76 (a)
NKX2-8 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKX2-8 35
  • 86.86 (n)
  • 88.56 (a)
NKX2-8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkx2-9 35
  • 79.15 (n)
  • 77.02 (a)
Nkx2-9 16
Nkx2-9 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NKX2-8 35
  • 99.58 (n)
  • 99.16 (a)
NKX2-8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkx2-8 35
  • 79.97 (n)
  • 79.4 (a)
oppossum
(Monodelphis domestica)
Mammalia NKX2-8 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKX2-8 35
  • 68 (n)
  • 62.22 (a)
NKX2-8 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkx2-8 35
  • 53.88 (n)
  • 52.43 (a)
zebrafish
(Danio rerio)
Actinopterygii nkx2.9 35
  • 60.84 (n)
  • 64.34 (a)
nkx2.2b 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta vnd 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-22 36
  • 21 (a)
OneToMany
Species with no ortholog for NKX2-8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKX2-8 Gene

ENSEMBL:
Gene Tree for NKX2-8 (if available)
TreeFam:
Gene Tree for NKX2-8 (if available)

Paralogs for NKX2-8 Gene

(4) SIMAP similar genes for NKX2-8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX2-8: view

Variants for NKX2-8 Gene

Sequence variations from dbSNP and Humsavar for NKX2-8 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_003753 -

Structural Variations from Database of Genomic Variants (DGV) for NKX2-8 Gene

Variant ID Type Subtype PubMed ID
esv32575 CNV Gain 17666407

Variation tolerance for NKX2-8 Gene

Gene Damage Index Score: 2.25; 40.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKX2-8 Gene

HapMap Linkage Disequilibrium report
NKX2-8
Human Gene Mutation Database (HGMD)
NKX2-8

PCR Panel Products

  • Copy Number PCR Panels: for NKX2-8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX2-8 Gene

Disorders for NKX2-8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NKX2-8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tethered spinal cord syndrome
  • spinal dysraphism
- elite association

Relevant External Links for NKX2-8

Genetic Association Database (GAD)
NKX2-8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKX2-8
genes like me logo Genes that share disorders with NKX2-8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NKX2-8 Gene

Publications for NKX2-8 Gene

  1. Regulation of alpha-fetoprotein expression by Nkx2.8. (PMID: 12167706) Kajiyama Y. … Locker J. (Mol. Cell. Biol. 2002) 23 67
  2. A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma. (PMID: 9446603) Apergis G.A. … Locker J. (J. Biol. Chem. 1998) 2 67
  3. Nkx2-8 downregulation promotes angiogenesis and activates NF-I_B in esophageal cancer. (PMID: 23604637) Lin C. … Li J. (Cancer Res. 2013) 67
  4. The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway. (PMID: 22223847) Yu C. … Song L. (Carcinogenesis 2012) 67
  5. Both gene amplification and allelic loss occur at 14q13.3 in lung cancer. (PMID: 21148747) Harris T. … Locker J. (Clin. Cancer Res. 2011) 67

Products for NKX2-8 Gene

Sources for NKX2-8 Gene

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