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NKX2-8 Gene

protein-coding   GIFtS: 47
GCID: GC14M037049

NK2 Homeobox 8

(Previous names: NK-2 homolog H (Drosophila), NK2 transcription factor related,...)
(Previous symbol: NKX2H)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NK2 Homeobox 81 2     Homeobox Protein Nkx-2.82
NKX2H1 2 3 5     NK-2 Homolog 82
Homeobox Protein NK-2 Homolog H2 3     NK-2 Homolog H2
NKX2.82 5     NK2 Transcription Factor Related, Locus 82
NK-2 Homolog H (Drosophila)1     NKX-2.83
NK2 Transcription Factor Related, Locus 8 (Drosophila)1     NKX2G3
Nkx2-92     

External Ids:    HGNC: 163641   Entrez Gene: 262572   Ensembl: ENSG000001363277   OMIM: 6032455   UniProtKB: O155223   

Export aliases for NKX2-8 gene to outside databases

Previous GC identifers: GC14M034430 GC14M030907 GC14M035039 GC14M036118 GC14M017163


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NKX2-8 Gene:
NKX2-8 (NK2 homeobox 8) is a protein-coding gene. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKX2-8 gene promoter:
         HSF1 (long)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   RORalpha2   FOXJ2 (long isoform)   HSF1short   Chx10   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKX2-8 promoter sequence
   Search Chromatin IP Primers for NKX2-8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKX2-8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.3   Ensembl cytogenetic band:  14q13.3   HGNC cytogenetic band: 14q13.3

NKX2-8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX2-8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M037049:  view genomic region     (about GC identifiers)

Start:
37,049,216 bp from pter      End:
37,051,812 bp from pter
Size:
2,597 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NKX28_HUMAN, O15522 (See protein sequence)
Recommended Name: Homeobox protein Nkx-2.8  
Size: 239 amino acids; 25866 Da
Secondary accessions: Q8IUT7

Explore the universe of human proteins at neXtProt for NKX2-8: NX_O15522

Explore proteomics data for NKX2-8 at MOPED


See NKX2-8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055175.2  
ENSEMBL proteins: 
 ENSP00000258829  

NKX2-8 Human Recombinant Protein Products:

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NKX2-8 Assay Products:

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Cloud-Clone Corp. ELISAs for NKX2-8
Cloud-Clone Corp. CLIAs for NKX2-8
Search eBioscience for ELISAs for NKX2-8 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
NKL: Homeoboxes / ANTP class : NKL subclass

4 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry O15522

ProtoNet protein and cluster: O15522

UniProtKB/Swiss-Prot: NKX28_HUMAN, O15522
Similarity: Belongs to the NK-2 homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with NKX2-8           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003690double-stranded DNA binding IDA9446603
GO:0003700sequence-specific DNA binding transcription factor activity IDA9446603
GO:0043565sequence-specific DNA binding IDA12167706
     
Find genes that share ontologies with NKX2-8           About GenesLikeMe


Phenotypes:
     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nkx2-9):
 cellular  mortality/aging  nervous system  respiratory system  tumorigenesis 

Find genes that share phenotypes with NKX2-8           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKX2-8
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NKX2-8

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKX2-8
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NKX2-8

miRNA
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Block miRNA regulation of human, mouse, rat NKX2-8 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate NKX2-8:
hsa-miR-3163 hsa-miR-2115 hsa-miR-300 hsa-miR-330-5p hsa-miR-326 hsa-miR-381 hsa-miR-4323 hsa-miR-138-2*
SwitchGear 3'UTR luciferase reporter plasmidNKX2-8 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for NKX2-8
Predesigned siRNA for gene silencing in human, mouse, rat NKX2-8

Gene Editing
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GenScript: all cDNA clones in your preferred vector: NKX2-8 (NM_014360)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKX2-8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX2-8

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NKX28_HUMAN, O15522: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005634nucleus IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKX2-8
Interactions:

    GeneGlobe Interaction Network for NKX2-8

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for NKX2-8 (ENSP000002588294) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
NKX2-2ENSP000003663474STRING: ENSP00000366347
NKX2-3ENSP000003428284STRING: ENSP00000342828
NKX2-5ENSP000003277584STRING: ENSP00000327758
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001889liver development NAS9446603
GO:0006351transcription, DNA-templated IDA9446603
GO:0006355regulation of transcription, DNA-templated ----
GO:0006366transcription from RNA polymerase II promoter IDA9446603
GO:0007409axonogenesis IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NKX2-8 (NKX28)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NKX2-8 gene: 
NM_014360.2  

Unigene Cluster for NKX2-8:

NK2 homeobox 8
Hs.234763  [show with all ESTs]
Unigene Representative Sequence: NM_014360
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000258829(uc001wtx.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat NKX2-8 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate NKX2-8:
hsa-miR-3163 hsa-miR-2115 hsa-miR-300 hsa-miR-330-5p hsa-miR-326 hsa-miR-381 hsa-miR-4323 hsa-miR-138-2*
SwitchGear 3'UTR luciferase reporter plasmidNKX2-8 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NKX2-8
Predesigned siRNA for gene silencing in human, mouse, rat NKX2-8
Clone
Products:
     
OriGene clones in human, mouse for NKX2-8 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NKX2-8 (NM_014360)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKX2-8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX2-8
Primer
Products:
    
OriGene qPCR primer pairs and template standards for NKX2-8
OriGene qSTAR qPCR primer pairs in human, mouse for NKX2-8
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NKX2-8
  QuantiTect SYBR Green Assays in human, mouse, rat NKX2-8
  QuantiFast Probe-based Assays in human, mouse, rat NKX2-8

Additional mRNA sequence: 

AF000295.1 AK313537.1 BC041090.1 

1 DOTS entry:

DT.404058 

10 AceView cDNA sequences:

BC041090 NM_014360 BX281241 AF000295 AI684194 BI830535 BE222075 BM920951 
BE669646 AW342086 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NKX2-8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCACCTCTG
NKX2-8 Expression
About this image


NKX2-8 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Brain (Nervous System)
         Myelinating Oligodendrocyte Cells Forebrain White Matter
NKX2-8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NKX2-8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.234763
    Custom PCR Arrays for NKX2-8
Primer
Products:
OriGene qPCR primer pairs and template standards for NKX2-8
OriGene qSTAR qPCR primer pairs in human, mouse for NKX2-8
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QuantiFast Probe-based Assays in human, mouse, rat NKX2-8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NKX2-8 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nkx2-91 , 5 NK2 transcription factor related, locus 9 (Drosophila)5
NK2 homeobox 91
79.15(n)1
77.02(a)1
  12 (24.47 cM)5
180941  NM_008701.21  NP_032727.21 
 566113895 
chicken
(Gallus gallus)
Aves NKX2-81 NK2 homeobox 8 68(n)
62.22(a)
  771397  XM_003641360.2  XP_003641408.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia nkx2-81 NK2 homeobox 8 53.88(n)
52.43(a)
  394548  NM_203620.1  NP_988951.1 
zebrafish
(Danio rerio)
Actinopterygii nkx2.91 NK2 transcription factor related, locus 9 (Drosophila) 60.84(n)
64.34(a)
  325615  NM_001099603.1  NP_001093073.1 
fruit fly
(Drosophila melanogaster)
Insecta vnd6
ventral nervous system defective
13(a)
1 → many
X(476732-491855)
worm
(Caenorhabditis elegans)
Secernentea ceh-226
Protein CEH-22, isoform c
21(a)
1 → many
V(10672459-10675644) WBGene00000445


ENSEMBL Gene Tree for NKX2-8 (if available)
TreeFam Gene Tree for NKX2-8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NKX2-8 gene
NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  TLX12  NKX2-32  HMX22  
NKX6-32  NKX3-22  NKX6-22  NKX2-62  NKX2-52  NKX2-22  NKX2-42  HMX12  
TLX32  
4 SIMAP similar genes for NKX2-8 using alignment to 1 protein entry:     NKX28_HUMAN:
NKX2-5    NKX2-4    NKX2-3    NKX2-2

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NKX2-8 (see all 93)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1845138111,2
--37048904(+) TGGCGC/TATCTC 1 -- int10--------
rs1470475401,2
--37048918(+) GCAGCG/TGGTGC 1 -- int10--------
rs1382713951,2
--37049065(+) CCCCAA/GGCGGC 1 -- int10--------
rs1894493541,2
--37049099(+) CCTCCC/TGGATC 1 -- int10--------
rs1155600661,2
C,F--37049321(+) CACTCT/CGGAAA 1 -- ut311Minor allele frequency- C:0.07WA 118
rs1773251,2
C,F,A--37049596(+) CTCCAT/ACCCCC 1 -- ut315Minor allele frequency- A:0.15NA MN WA 322
rs749497441,2
C,F--37049606(+) CAGGTA/GTCTTC 1 -- ut311Minor allele frequency- G:0.10WA 118
rs1167900251,2
C,F--37049888(+) CTGGGG/ACTGGC 1 -- ut311Minor allele frequency- A:0.10WA 118
rs1806864691,2
--37049951(+) TGCGCA/GACGGC 1 -- ut310--------
rs2007543271,2
--37050154(+) GTAGGC/GGGGGA 2 P A mis10--------

HapMap Linkage Disequilibrium report for NKX2-8 (37049216 - 37051812 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for NKX2-8:    About this table    
Variant IDTypeSubtypePubMed ID
esv32575CNV Gain17666407

Human Gene Mutation Database (HGMD): NKX2-8
Site Specific Mutation Identification with PCR Assays
1 Copy Number PCR Panel containing NKX2-8:
Lung Cancer
SeqTarget long-range PCR primers for resequencing NKX2-8
DNA2.0 Custom Variant and Variant Library Synthesis for NKX2-8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603245    OMIM disorders: --


Find genes that share disorders with NKX2-8           About GenesLikeMe

Genetic Association Database (GAD): NKX2-8

Export disorders for NKX2-8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NKX2-8 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with NKX2-8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma. (PubMed id 9446603)1, 2, 3 Apergis G.A.... Locker J. (J. Biol. Chem. 1998)
  2. Regulation of alpha-fetoprotein expression by Nkx2.8. (PubMed id 12167706)1, 9 Kajiyama Y....Locker J. (Mol. Cell. Biol. 2002)
  3. Nkx2-8 downregulation promotes angiogenesis and activates NF-I_B in esophageal cancer. (PubMed id 23604637)1 Lin C....Li J. (Cancer Res. 2013)
  4. The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway. (PubMed id 22223847)1 Yu C....Song L. (Carcinogenesis 2012)
  5. Both gene amplification and allelic loss occur at 14q13.3 in lung cancer. (PubMed id 21148747)1 Harris T....Locker J. (Clin. Cancer Res. 2011)
  6. Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. (PubMed id 19279207)1 Hsu D.S....Potti A. (Proc. Natl. Acad. Sci. U.S.A. 2009)
  7. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
  8. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
  9. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. (PubMed id 15235609)1 Hamamoto R.... Nakamura Y. (Nat. Cell Biol. 2004)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26257 HGNC: 16364 AceView: NKX2-8 Ensembl:ENSG00000136327 euGenes: HUgn26257
ECgene: NKX2-8 H-InvDB: NKX2-8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NKX2-8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NKX2-8 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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