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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKX2-8 Gene

protein-coding   GIFtS: 44
GCID: GC14M037049

NK2 homeobox 8

(Previous names: NK-2 homolog H (Drosophila), NK2 transcription factor related,...)
(Previous symbol: NKX2H)
 Explore 3 diseases affiliated with
NKX2-8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NKX2-8    

Aliases
for NKX2-8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NK2 Homeobox 81 2     Homeobox Protein Nkx-2.82
NKX2H1 2 3 5     NK-2 Homolog 82
NKX2.81 2 5     NK-2 Homolog H2
Nkx2-91 2     NK2 Transcription Factor Related, Locus 82
Homeobox Protein NK-2 Homolog H2 3     NKX-2.83
NK-2 Homolog H (Drosophila)1     NKX2G3
NK2 Transcription Factor Related, Locus 8 (Drosophila)1     

External Ids:    HGNC: 163641   Entrez Gene: 262572   Ensembl: ENSG000001363277   OMIM: 6032455   UniProtKB: O155223   

Export aliases for NKX2-8 gene to outside databases

Previous GC identifers: GC14M034430 GC14M030907 GC14M035039 GC14M036118 GC14M017163


Summaries
for NKX2-8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for NKX2-8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKX2-8 gene promoter:
         HSF1 (long)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   RORalpha2   FOXJ2 (long isoform)   HSF1short   Chx10   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKX2-8 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKX2-8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX2-8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.3   Ensembl cytogenetic band:  14q13.3   HGNC cytogenetic band: 14q13.3

NKX2-8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX2-8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M037049:  view genomic region     (about GC identifiers)

Start:
 37,049,216 bp from pter      End:
 37,051,812 bp from pter
Size:
 2,597 bases      Orientation:
 minus strand

Proteins
for NKX2-8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NKX28_HUMAN, O15522 (See protein sequence)
Recommended Name: Homeobox protein Nkx-2.8  
Size: 239 amino acids; 25866 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8IUT7

Explore the universe of human proteins at neXtProt for NKX2-8: NX_O15522

NKX2-8 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_055175.2  
ENSEMBL proteins: 
 ENSP00000258829  

Human Recombinant Protein Products: 
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Novus Biologicals NKX2-8 Proteins
Novus Biologicals NKX2-8 Lysates
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Browse ProSpec Recombinant Proteins
Uscn Proteins for NKX2-8

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005634nucleus IEA--


NKX2-8 for ontologies           About GeneDecksing



NKX2-8 Antibody Products: 
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Uscn Antibodies for NKX2-8
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Uscn ELISAs and CLIAs for NKX2-8

Protein Domains /
Families
for NKX2-8 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
NKX2-8 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR017970 Homeobox_CS
 IPR020479 Homeobox_metazoa
 IPR001356 Homeodomain
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry O15522

ProtoNet protein and cluster: O15522

UniProtKB/Swiss-Prot: NKX28_HUMAN, O15522
Similarity: Belongs to the NK-2 homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Function
for NKX2-8 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
Products:    		Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKX2-8
8 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX2-8:
hsa-miR-3163 hsa-miR-2115 hsa-miR-300 hsa-miR-330-5p hsa-miR-326 hsa-miR-381 hsa-miR-4323 hsa-miR-138-2*
SwitchGear 3'UTR luciferase reporter plasmid: NKX2-8 3' UTR sequence
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKX2-8
OriGene shRNA RFP: NKX2-8
OriGene siRNA: NKX2-8
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX2-8

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for NKX2-8

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-8
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GenScript: all cDNA clones in your preferred vector: NKX2-8 (NM_014360)
Browse Sino Biological Human cDNA Clones
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX2-8 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for NKX2-8
Search LifeMap BioReagents cell lines for NKX2-8

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-8

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003690double-stranded DNA binding IDA9446603
GO:0003700sequence-specific DNA binding transcription factor activity IDA9446603
GO:0043565sequence-specific DNA binding IDA12167706


NKX2-8 for ontologies           About GeneDecksing


Animal Models:
     5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nkx2-9):
 cellular  mortality/aging  nervous system  respiratory system  tumorigenesis 

NKX2-8 for phenotypes           About GeneDecksing


Pathways & Interactions
for NKX2-8 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NKX2-8

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001889liver development NAS9446603
GO:0006351transcription, DNA-dependent IDA9446603
GO:0006355regulation of transcription, DNA-dependent ----
GO:0006366transcription from RNA polymerase II promoter IDA9446603
GO:0007409axonogenesis IEA--


NKX2-8 for ontologies           About GeneDecksing



Drugs & Compounds
for NKX2-8 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NKX2-8
Search CenterWatch for drugs/clinical trials and news about NKX2-8 / NKX28 

Transcripts
for NKX2-8 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for NKX2-8 gene: 
NM_014360.2  

Unigene Cluster for NKX2-8:

NK2 homeobox 8
Hs.234763  [show with all ESTs]
Unigene Representative Sequence: NM_014360
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000258829(uc001wtx.3)

miRNA
Products:     		Browse 3'-UTR reporter clones for miRNA target validation
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKX2-8
8 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX2-8:
hsa-miR-3163 hsa-miR-2115 hsa-miR-300 hsa-miR-330-5p hsa-miR-326 hsa-miR-381 hsa-miR-4323 hsa-miR-138-2*
SwitchGear 3'UTR luciferase reporter plasmid: NKX2-8 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKX2-8
OriGene shRNA RFP: NKX2-8
OriGene siRNA: NKX2-8
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX2-8
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: NKX2-8 (NM_014360)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKX2-8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX2-8 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NKX2-8
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NKX2-8
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX2-8
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX2-8

Additional cDNA sequence: 

AF000295.1 AK313537.1 BC041090.1 

1 DOTS entry:

DT.404058 

10 AceView cDNA sequences:

BC041090 BX281241 NM_014360 AF000295 AI684194 BE222075 BI830535 BE669646 
BM920951 AW342086 

GeneLoc Exon Structure


Expression
for NKX2-8 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NKX2-8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACCTCTG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

NKX2-8 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Primitive gut tube-like cells (A scalable, suspensi...)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See NKX2-8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NKX2-8

SOURCE GeneReport for Unigene cluster: Hs.234763
    SABiosciences Custom PCR Arrays for NKX2-8
Primer
Products:		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NKX2-8
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NKX2-8
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX2-8
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX2-8
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-8

Orthologs
for NKX2-8 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for NKX2-8 gene from 4/16 species (see all 16)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves LOC7713971 homeobox protein Nkx-2.8-like 69.17(n)
65.49(a)		   771397  XM_003641360.1  XP_003641408.1 
zebrafish
(Danio rerio)		 Actinopterygii nkx2.91 NK2 transcription factor related, locus 9 (Drosophila) 57.42(n)
55.98(a)		   325615  NM_001099603.1  NP_001093073.1 
fruit fly
(Drosophila melanogaster)		 Insecta vnd6
 ventral nervous system defective
 10(a)
 1 → many
 X(476732-491855)
worm
(Caenorhabditis elegans)		 Secernentea ceh-226
ceh-276
 Homeobox family member (ceh-27)
 20(a)
18(a)
 possible ortholog
possible ortholog
 V(10672438-10675623)
V(11661535-11664679)


ENSEMBL Gene Tree for NKX2-8 (if available)
TreeFam Gene Tree for NKX2-8 (if available) 

Paralogs
for NKX2-8 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for NKX2-8 gene
NKX2-32  TLX12  HMX22  NKX3-22  NKX2-62  NKX2-12  NKX2-52  NKX2-22  
LBX12  HMX32  NKX2-42  TLX32  HMX12  TLX22  LBX22  NKX3-12  
4 SIMAP similar genes for NKX2-8 using alignment to 1 protein entry:     NKX28_HUMAN:
NKX2-5    NKX2-4    NKX2-3    NKX2-2

NKX2-8 for paralogs           About GeneDecksing



Genomic Variants
for NKX2-8 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/65 NCBI SNPs in NKX2-8 are shown (see all 65)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 14 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1845138111,2
--37048904(+) TGGCGC/TATCTC 1 -- int10--------
rs1470475401,2
--37048918(+) GCAGCG/TGGTGC 1 -- int10--------
rs1382713951,2
--37049065(+) CCCCAA/GGCGGC 1 -- int10--------
rs1894493541,2
--37049099(+) CCTCCC/TGGATC 1 -- int10--------
rs1155600661,2
C,F,--37049321(+) CACTCT/CGGAAA 1 -- ut311Minor allele frequency- C:0.07WA 118
rs1773251,2
C,F,A,--37049596(+) CTCCAT/ACCCCC 1 -- ut315Minor allele frequency- A:0.15NA MN WA 322
rs749497441,2
C,F,--37049606(+) CAGGTA/GTCTTC 1 -- ut311Minor allele frequency- G:0.10WA 118
rs1167900251,2
F,--37049888(+) CTGGGG/ACTGGC 1 -- ut311Minor allele frequency- A:0.10WA 118
rs1806864691,2
--37049951(+) TGCGCA/GACGGC 1 -- ut310--------
rs2007543271,2
--37050154(+) GTAGGC/GGGGGA 2 P A mis10--------

HapMap Linkage Disequilibrium report for NKX2-8 (37049216 - 37051812 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NKX2-8
     1 CNV: 7034

SABiosciences Cancer Mutation PCR Assays
1 SABiosciences qBiomarker Copy Number PCR Array containing NKX2-8:
Lung Cancer
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKX2-8
DNA2.0 Custom Variant and Variant Library Synthesis for NKX2-8

Disorders / Diseases
for NKX2-8 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
NKX2-8 for disorders           About GeneDecksing

OMIM gene information: 603245    OMIM disorders: --

3 diseases for NKX2-8:    About MalaCards
hepatocellular carcinoma    lung cancer    carcinoma


Export disorders for NKX2-8 gene to outside databases

Publications
for NKX2-8 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NKX2-8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NKX2-8)		    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma. (PubMed id 9446603)1, 2, 3 Apergis G.A.... Locker J. (1998)
  2. Regulation of alpha-fetoprotein expression by Nkx2.8. (PubMed id 12167706)1, 9 Kajiyama Y....Locker J. (2002)
  3. The tumor-suppressor gene Nkx2.8 suppresses bladder ca ncer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway. (PubMed id 22223847)1 Yu C....Song L. (2012)
  4. Both gene amplification and allelic loss occur at 14q 13.3 in lung cancer. (PubMed id 21148747)1 Harris T....Locker J. (2011)
  5. Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. (PubMed id 19279207)1 Hsu D.S....Potti A. (2009)
  6. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. (PubMed id 15235609)1 Hamamoto R.... Nakamura Y. (2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes. (PubMed id 11252173)1 Santagati F....Imai K. (2001)

External Searches for NKX2-8 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing NKX2-8 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 26257 HGNC: 16364 AceView: NKX2-8 Ensembl:ENSG00000136327 euGenes: HUgn26257
ECgene: NKX2-8 H-InvDB: NKX2-8

Other Databases showing NKX2-8 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing NKX2-8 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for NKX2-8 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for NKX2-8 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for NKX2-8 gene:
Search GeneIP for patents involving NKX2-8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for NKX2-8 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
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 Browse OriGene Antibodies   OriGene shRNA RFP for NKX2-8  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKX2-8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NKX2-8  
 OriGene Protein Over-expression Lysate for NKX2-8   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for NKX2-8   Browse 3'-UTR reporter clones for miRNA target validation  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-8  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 OriGene Purified Protein for NKX2-8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for NKX2-8   OriGene Custom Protein Services for NKX2-8  
 OriGene Custom Immunoassay Development  

 		 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NKX2-8
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKX2-8
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX2-8
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX2-8
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX2-8
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX2-8
 GenScript Custom Purified and Recombinant Proteins Services for NKX2-8 GenScript cDNA clones with any tag delivered in your preferred vector for NKX2-8
 GenScript Custom Assay Services for NKX2-8 GenScript Custom Superior Antibodies Services for NKX2-8
 GenScript Custom overexpressing Cell Line Services for NKX2-8 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
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 Regulatory tfbs in NKX2-8 promoter
 Search Chromatin IP Primers for NKX2-8
 RT2 qPCR Primer Assay in human, mouse / rat NKX2-8
 GNC Network for NKX2-8
 SABiosciences Custom PCR Arrays for NKX2-8
 Search Tocris compounds for NKX2-8
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 NKX2-8 antibodies
 NKX2-8 proteins
 NKX2-8 lysates
 Search for Antibodies for NKX2-8 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for NKX2-8
 Custom Antibody / Protein Production Service
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 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 NKX2-8 Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for NKX2-8
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-8
 SwitchGear 3'UTR luciferase reporter plasmids for NKX2-8
 SwitchGear Promoter luciferase reporter plasmids for NKX2-8
 Search ThermoFisher Antibodies for NKX2-8
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX2-8
       
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