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NKX2-6 Gene

protein-coding   GIFtS: 37
GCID: GC08M023559

NK2 Homeobox 6

(Previous names: NK2 transcription factor related, locus 6 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NK2 Homeobox 61 2     Homeobox Protein NK2 Homolog F2
NKX2F2 3     Homeobox Protein Nkx-2.62
CSX22 5     Homeobox Protein NKX2.62
NK2 Transcription Factor Related, Locus 6 (Drosophila)1     NK2 Transcription Factor Related, Locus 62
Tinman Paralog (Drosophila)1     Tinman Paralog2
NKX4-22     Homeobox Protein NK-2 Homolog F3

External Ids:    HGNC: 329401   Entrez Gene: 1378142   Ensembl: ENSG000001800537   OMIM: 6117705   UniProtKB: A6NCS43   

Export aliases for NKX2-6 gene to outside databases

Previous GC identifers: GC08M023616 GC08M022105


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NKX2-6 Gene:
This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a
vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be
essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene
may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with
persistent truncus arteriosus.(provided by RefSeq, Aug 2011)

GeneCards Summary for NKX2-6 Gene:
NKX2-6 (NK2 homeobox 6) is a protein-coding gene. Diseases associated with NKX2-6 include persistent truncus arteriosus, and conjunctivitis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

UniProtKB/Swiss-Prot: NKX26_HUMAN, A6NCS4
Function: In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKX2-6 gene promoter:
         TBP   NF-1   NF-1/L   GCNF   C/EBPalpha   N-Myc   GCNF-1   FOXO1a   GCNF-2   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NKX2-6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKX2-6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

NKX2-6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX2-6 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M023559:  view genomic region     (about GC identifiers)

Start:
23,559,964 bp from pter      End:
23,564,111 bp from pter
Size:
4,148 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NKX26_HUMAN, A6NCS4 (See protein sequence)
Recommended Name: Homeobox protein Nkx-2.6  
Size: 301 amino acids; 32121 Da

Explore the universe of human proteins at neXtProt for NKX2-6: NX_A6NCS4

Explore proteomics data for NKX2-6 at MOPED


See NKX2-6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001129743.2  
ENSEMBL proteins: 
 ENSP00000320089   ENSP00000402231  

NKX2-6 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for NKX2-6

NKX2-6 Assay Products:

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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
NKL: Homeoboxes / ANTP class : NKL subclass

4 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry A6NCS4

ProtoNet protein and cluster: A6NCS4

UniProtKB/Swiss-Prot: NKX26_HUMAN, A6NCS4
Similarity: Belongs to the NK-2 homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


NKX2-6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NKX26_HUMAN, A6NCS4
Function: In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (By
similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IDA15649947
GO:0043565sequence-specific DNA binding IEA--
     
NKX2-6 for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nkx2-6):
 cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
 mortality/aging  normal  respiratory system 

NKX2-6 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Nkx2-6Nkx2-tm1Siz for NKX2-6

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKX2-6
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NKX2-6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKX2-6
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NKX2-6

miRNA
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Block miRNA regulation of human, mouse, rat NKX2-6 using miScript Target Protectors
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat NKX2-6

Gene Editing
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OriGene clones in human, mouse for NKX2-6 (see all 4)
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Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NKX2-6

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NKX26_HUMAN, A6NCS4: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IC15649947

NKX2-6 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKX2-6
Interactions:

    Search GeneGlobe Interaction Network for NKX2-6

Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IDA15649947
GO:0006355regulation of transcription, DNA-templated ----
GO:0007507heart development ----
GO:0008284positive regulation of cell proliferation ISS--
GO:0021854hypothalamus development ISS--

NKX2-6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NKX2-6 (NKX26)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NKX2-6 gene: 
NM_001136271.2  

Unigene Cluster for NKX2-6:

NK2 homeobox 6
Hs.532654  [show with all ESTs]
Unigene Representative Sequence: NM_001136271
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000325017(uc011kzy.2) ENST00000418222
miRNA
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Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat NKX2-6
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GenScript: all cDNA clones in your preferred vector: NKX2-6 (NM_001136271)
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Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NKX2-6
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NKX2-6
  QuantiTect SYBR Green Assays in human, mouse, rat NKX2-6
  QuantiFast Probe-based Assays in human, mouse, rat NKX2-6

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NKX2-6 expression in normal human tissues (normalized intensities)      NKX2-6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NKX2-6 Expression
About this image


NKX2-6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Heart (Cardiovascular System)    fully expand to see all 2 entries
         Primitive Heart Tube Cells Primitive Heart Tube
         Heart Tube
NKX2-6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NKX2-6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.532654
    Custom PCR Arrays for NKX2-6
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for NKX2-6
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NKX2-6
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QuantiFast Probe-based Assays in human, mouse, rat NKX2-6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NKX2-6 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nkx2-61 , 5 NK2 transcription factor related, locus 6 (Drosophila)5
NK2 homeobox 61
71.76(n)1
61.81(a)1
  14 (36.01 cM)5
180921  NM_010920.21  NP_035050.21 
 691715765 
chicken
(Gallus gallus)
Aves NKX2-61 NK2 homeobox 6 63.81(n)
65.24(a)
  396037  NM_205137.1  NP_990468.1 
lizard
(Anolis carolinensis)
Reptilia --
--
78(a)
many ↔ many
3(38400551-38400946)
tropical clawed frog
(Xenopus tropicalis)
Amphibia nkx2-61 NK2 homeobox 6 60.78(n)
61.85(a)
  100038094  XM_002932553.2  XP_002932599.1 
zebrafish
(Danio rerio)
Actinopterygii nkx2.71 NK2 transcription factor related 7 54.97(n)
53.88(a)
  30694  NM_131419.1  NP_571494.1 
fruit fly
(Drosophila melanogaster)
Insecta tin6
tinman
18(a)
1 → many
3R(17204701-17207692)
worm
(Caenorhabditis elegans)
Secernentea ceh-286
Protein CEH-28 (ceh-28) mRNA, complete cds
33(a)
1 → many
X(13074682-13076092) WBGene00000450


ENSEMBL Gene Tree for NKX2-6 (if available)
TreeFam Gene Tree for NKX2-6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NKX2-6 gene
NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  TLX12  NKX2-32  HMX22  
NKX6-32  NKX3-22  NKX6-22  NKX2-82  NKX2-52  NKX2-22  NKX2-42  HMX12  
TLX32  
11 SIMAP similar genes for NKX2-6 using alignment to 2 protein entries:     NKX26_HUMAN (see all proteins):
NKX2-5    HMX2    HLX    HOXB1    NKX2-2    NKX2-3
HOXA4    DLX6    NKX3-1    CDX1    NKX2-4

NKX2-6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NKX2-6 (see all 169)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0632784
Conotruncal heart malformations (CTHM)4--see VAR_0632782 F L mis40--------
rs114021241,2
C--23561226(+) ACAAA-/C/    
   CAAAA
AAACA
1 -- int12NA CSA 4
rs669861521,2
C--23561227(+) CAAAA-/CAACAA 1 -- int10--------
rs1126568021,2
C,F--23566105(+) CTCCTC/TCTCCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs1860532241,2
--23813760(+) CCCGCC/TCTCCC 1 -- ds50010--------
rs1148829701,2
F--23813865(+) TGCTGC/GGTACA 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs117763771,2
H--23813893(+) GGCCTA/CTGGGG 1 -- ds50010--------
rs1908228571,2
--23813945(+) CCCCAA/GACTGC 1 -- ds50010--------
rs1831739831,2
--23813965(+) TTGGTA/GTTCTT 1 -- ds50010--------
rs70008621,2
C,F,A,H--23814012(+) GGTCTT/CCTTTT 1 -- ds500114Minor allele frequency- C:0.47NS WA NA CSA EA 439

HapMap Linkage Disequilibrium report for NKX2-6 (23559964 - 23564111 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for NKX2-6:    About this table    
Variant IDTypeSubtypePubMed ID
nsv831269CNV Gain17160897

Human Gene Mutation Database (HGMD): NKX2-6
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NKX2-6
DNA2.0 Custom Variant and Variant Library Synthesis for NKX2-6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611770   
OMIM disorders: 217095  
UniProtKB/Swiss-Prot: NKX26_HUMAN, A6NCS4
  • Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the
    outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of
    great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate
    aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and
    the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery
    and aorta arise from the right ventricle. Note=The disease may be caused by mutations affecting the gene
    represented in this entry

  • 12 diseases for NKX2-6:    About MalaCards
    persistent truncus arteriosus    conjunctivitis    conotruncal heart malformations    pharyngitis
    velocardiofacial syndrome    double outlet right ventricle    transposition of the great arteries    congenital heart defect
    digeorge syndrome    sepsis    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for NKX2-6:
    Velocardiofacial syndrome

    NKX2-6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NKX2-6

    Export disorders for NKX2-6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKX2-6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NKX2-6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common arterial trunk associated with a homeodomain mutation of NKX2.6. (PubMed id 15649947)1, 2, 3 Heathcote K.... Syrris P. (Hum. Mol. Genet. 2005)
    2. Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. (PubMed id 22310353)1, 4 Man M....Garcia J.G. (Pharmacogenomics J. 2013)
    3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1, 2 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    4. Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products. (PubMed id 18316326)1 Nagase T....Ohara O. (DNA Res. 2008)
    5. NKX2.5/NKX2.6 mutations are not a common cause of isolated type 1 truncus arteriosus in a small cohort of multiethnic cases. (PubMed id 18939937)1 Khetyar M....Carter N. (Genet. Test. 2008)
    6. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    7. tinman-related genes expressed during heart development in Xenopus. (PubMed id 9621430)1 Newman C.S. and Krieg P.A. (Dev. Genet. 1998)
    8. Assignment of cardiac homeobox gene CSX to human chromosome 5q34. (PubMed id 7665173)1 Shiojima I....Yazaki Y. (Genomics 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 137814 HGNC: 32940 Ensembl:ENSG00000180053 euGenes: HUgn137814 ECgene: NKX2-6
    H-InvDB: NKX2-6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NKX2-6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NKX2-6 gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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