NKX2-4 Gene
protein-coding GIFtS: 35
GCID: GC20M021371
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NK2 homeobox 4(Previous names: NK-2 (Drosophila) homolog D, NK2 transcription factor related,...)
(Previous symbol: NKX2D)
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Aliases
for NKX2-4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NK2 Homeobox 41 2 | | NK2 Transcription Factor Related, Locus 4 (Drosophila)1 | | NKX2D1 2 3 5 | | Homeobox Protein Nkx-2.42 | | NKX2.41 2 | | NK-2 Homolog D2 | | Homeobox Protein NK-2 Homolog D2 3 | | NK2 Transcription Factor Homolog D2 | | NK-2 (Drosophila) Homolog D1 | | NK2 Transcription Factor Related, Locus 42 |
Export aliases for NKX2-4 gene to outside databasesPrevious GC identifers: GC20U990020 GC20M021324 |
Summaries
for NKX2-4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NKX24_HUMAN, Q9H2Z4Function: Probable transcription factor
|
Genomic Views
for NKX2-4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NKX2-4 gene promoter:
Egr-2 Egr-3 FOXF2 p53 ARP-1 CUTL1 LCR-F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NKX2-4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX2-4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.22 Ensembl cytogenetic band: 20p11.22 HGNC cytogenetic band: 20p11.22NKX2-4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M021371: view genomic region
(about GC identifiers)
Start:
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21,376,005 bp from pter |
End:
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21,378,666 bp from pter |
Size:
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2,662 bases |
Orientation:
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minus strand |
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Proteins
for NKX2-4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NKX24_HUMAN, Q9H2Z4 (See
protein sequence)Recommended Name: Homeobox protein Nkx-2.4 Size: 354 amino acids; 36179 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5VZV8Explore the universe of human proteins at neXtProt for NKX2-4: NX_Q9H2Z4
NKX2-4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149416.1
ENSEMBL proteins: ENSP00000345147
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NKX2-4 for ontologies About GeneDecksing
NKX2-4 Antibody Products:
Assay Products for NKX2-4: |
Protein
Domains /
Families
for NKX2-4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NKX2-4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H2Z4ProtoNet protein and cluster: Q9H2Z4 UniProtKB/Swiss-Prot: NKX24_HUMAN, Q9H2Z4Similarity: Belongs to the NK-2 homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for NKX2-4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NKX24_HUMAN, Q9H2Z4Function: Probable transcription factor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
NKX2-4 for ontologies About GeneDecksing
|
Pathways & Interactions
for NKX2-4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKX2-4
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for NKX2-4 (ENSP000003451474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
NKX2-4 for ontologies About GeneDecksing
|
Drugs & Compounds
for NKX2-4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NKX2-4
Search CenterWatch for drugs/clinical trials and news about NKX2-4 / NKX24
|
Transcripts
for NKX2-4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NKX2-4 gene: NM_033176.1 Unigene Cluster for NKX2-4: NK2 homeobox 4 Hs.456662 [show with all ESTs]Unigene Representative Sequence: NM_0331761 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000351817(uc010gcz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NKX2-4 (NM_033176) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NKX2-4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NKX2-4 |
1 DOTS entry: DT.100749639
GeneLoc Exon Structure
|
Expression
for NKX2-4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NKX2-4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCACCTGA
About this image
See NKX2-4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.456662
SABiosciences Custom PCR Arrays for NKX2-4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NKX2-4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NKX2-4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX2-4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX2-4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-4 |
Orthologs
for NKX2-4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NKX2-4 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1N8W4_CHICK6 |
thyroid transcription factor 1 |
50(a) |
possible ortholog |
5(39014608-39016765) |
lizard
(Anolis carolinensis) |
Reptilia |
NKX2-16NKX2-46 |
-- |
50(a)37(a) |
possible orthologpossible ortholog |
1(24643978-24650302) LGf(4247662-4251929) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1715311 |
zgc:171531 |
68.96(n)
72.5(a) |
|
562300 NM_001111166.1 NP_001104636.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
scro6 |
scarecrow |
30(a) |
1 → many |
3LHet(207493-252455) |
worm
(Caenorhabditis elegans) |
Secernentea |
ceh-246 |
Homeobox protein ceh-24 |
24(a) |
possible ortholog |
V(13813295-13815258) |
ENSEMBL Gene Tree for NKX2-4 (if available)
TreeFam Gene Tree for NKX2-4 (if available) |
Paralogs
for NKX2-4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NKX2-4 gene
- NKX2-12 HMX32 LBX22 TLX22 NKX3-12 TLX12 NKX2-32 HMX22
- NKX3-22 NKX2-62 NKX2-82 NKX2-52 LBX12 NKX2-22 HMX12 TLX32
7 SIMAP similar genes for NKX2-4 using alignment to 1 protein entry: NKX24_HUMAN:HLX NKX2-8 NKX2-1 NKX2-3 NKX2-2 NKX2-5
NKX2-6
NKX2-4 for paralogs About GeneDecksing
|
Genomic Variants
for NKX2-4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NKX2-4 (21376005 - 21378666 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NKX2-4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKX2-4 |
|
Disorders
/ Diseases
for NKX2-4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NKX2-4 for disorders About GeneDecksing
OMIM gene information: 607808
OMIM disorders: --
1  disease for NKX2-4: About MalaCardsthyroiditis
Export disorders for NKX2-4 gene to outside databases
|
Publications
for NKX2-4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NKX2-4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NKX2-4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2- 1/2-9 in mammals. (PubMed id 10818213)1, 2, 3 Wang C.-C.... Harvey R.P. (2000)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Regional expression of the homeobox gene Nkx-2.2 in t he developing mammalian forebrain. (PubMed id 1346742)1, 3 Price M....Di Lauro R. (1992)
|
External Searches for NKX2-4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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|
Genome Databases showing NKX2-4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NKX2-4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NKX2-4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NKX2-4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NKX2-4 gene:
Search GeneIP for patents involving NKX2-4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NKX2-4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NKX2-4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKX2-4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NKX2-4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NKX2-4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NKX2-4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKX2-4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX2-4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX2-4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX2-4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX2-4 |
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 |  |  |  | |
| | | | Search Tocris compounds for NKX2-4 |
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 | | | NKX2-4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-4 |
|  |  |  | | | | Search ThermoFisher Antibodies for NKX2-4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NKX2-4 |
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