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Aliases for NKX2-4 Gene

Aliases for NKX2-4 Gene

  • NK2 Homeobox 4 2 3 5
  • NKX2D 3 4
  • NK2 Transcription Factor Related, Locus 4 (Drosophila) 2
  • NK2 Transcription Factor Related, Locus 4 3
  • NK2 Transcription Factor Homolog D 3
  • Homeobox Protein NK-2 Homolog D 4
  • NK-2 (Drosophila) Homolog D 2
  • Homeobox Protein Nkx-2.4 3
  • NKX2.4 3

External Ids for NKX2-4 Gene

Previous HGNC Symbols for NKX2-4 Gene

  • NKX2D

Previous GeneCards Identifiers for NKX2-4 Gene

  • GC20U990020
  • GC20M021324

Summaries for NKX2-4 Gene

GeneCards Summary for NKX2-4 Gene

NKX2-4 (NK2 Homeobox 4) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is NKX2-1.

UniProtKB/Swiss-Prot for NKX2-4 Gene

  • Probable transcription factor.

Additional gene information for NKX2-4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX2-4 Gene

Genomics for NKX2-4 Gene

Regulatory Elements for NKX2-4 Gene

Enhancers for NKX2-4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H021090 1.5 Ensembl 11.1 +307.7 307728 0 MEF2D SOX6 PRDM4 SP7 LOC105372558 NKX2-4 ENSG00000283405 LINC00237
GH20H021091 0.7 ENCODE 11.1 +307.2 307174 0 ZSCAN18 ZNF133 INSM2 FEZF1 ZEB1 HIC1 ZNF366 SCRT2 ZNF391 KLF8 LOC105372558 NKX2-4 ENSG00000283405 LINC00237
GH20H021360 0.7 Ensembl ENCODE 11.1 +36.8 36779 0 PRDM6 ARNT CEBPB LOC105372558 NKX2-4 GC20M021329 GC20M021330
GH20H021521 1.1 FANTOM5 dbSUPER 4.4 -123.3 -123273 0 CTCF SUZ12 ZFHX2 GLIS2 PATZ1 EGR2 EZH2 ZBTB10 ZNF654 L3MBTL2 NKX2-2 PAX1 NKX2-4 KIZ GC20P021523
GH20H021214 0.2 ENCODE 10 +183.6 183641 0 LOC105372558 NKX2-4 KIZ-AS1 RPS15AP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NKX2-4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NKX2-4 Gene

21,395,367 bp from pter
21,398,028 bp from pter
2,662 bases
Minus strand

Genomic View for NKX2-4 Gene

Genes around NKX2-4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKX2-4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKX2-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX2-4 Gene

Proteins for NKX2-4 Gene

  • Protein details for NKX2-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Nkx-2.4
    Protein Accession:
    Secondary Accessions:
    • Q5VZV8

    Protein attributes for NKX2-4 Gene

    354 amino acids
    Molecular mass:
    36179 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKX2-4 Gene

Post-translational modifications for NKX2-4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKX2-4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX2-4 Gene

Domains & Families for NKX2-4 Gene

Gene Families for NKX2-4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NKX2-4 Gene

Suggested Antigen Peptide Sequences for NKX2-4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NK-2 homeobox family.
  • Belongs to the NK-2 homeobox family.
genes like me logo Genes that share domains with NKX2-4: view

Function for NKX2-4 Gene

Molecular function for NKX2-4 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor.

Gene Ontology (GO) - Molecular Function for NKX2-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NKX2-4: view

Phenotypes for NKX2-4 Gene

GenomeRNAi human phenotypes for NKX2-4:
genes like me logo Genes that share phenotypes with NKX2-4: view

Animal Model Products

CRISPR Products

miRNA for NKX2-4 Gene

miRTarBase miRNAs that target NKX2-4

Clone Products

  • Applied Biological Materials Clones for NKX2-4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKX2-4 Gene

Localization for NKX2-4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX2-4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKX2-4 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NKX2-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NKX2-4: view

Pathways & Interactions for NKX2-4 Gene

SuperPathways for NKX2-4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKX2-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NKX2-4: view

No data available for Pathways by source and SIGNOR curated interactions for NKX2-4 Gene

Drugs & Compounds for NKX2-4 Gene

No Compound Related Data Available

Transcripts for NKX2-4 Gene

mRNA/cDNA for NKX2-4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKX2-4 Gene

NK2 homeobox 4:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for NKX2-4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NKX2-4 Gene

No ASD Table

Relevant External Links for NKX2-4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKX2-4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKX2-4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKX2-4 Gene

This gene is overexpressed in Testis (x26.7), Brain - Hypothalamus (x12.6), and Uterus (x6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NKX2-4 Gene

SOURCE GeneReport for Unigene cluster for NKX2-4 Gene:

genes like me logo Genes that share expression patterns with NKX2-4: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKX2-4 Gene

Orthologs for NKX2-4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX2-4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NKX2-4 33 34
  • 99.72 (n)
(Bos Taurus)
Mammalia NKX2-4 34
  • 94 (a)
(Mus musculus)
Mammalia Nkx2-4 33 16 34
  • 90.38 (n)
(Rattus norvegicus)
Mammalia Nkx2-4 33
  • 89.88 (n)
(Canis familiaris)
Mammalia NKX2-4 33 34
  • 88.96 (n)
(Monodelphis domestica)
Mammalia NKX2-4 34
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nkx2-4 33
  • 68.23 (n)
(Danio rerio)
Actinopterygii nkx2.1a 34
  • 69 (a)
zgc:171531 33 34
  • 66.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta scro 33 34
  • 51.2 (n)
(Caenorhabditis elegans)
Secernentea ceh-24 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CS-TTF1 34
  • 27 (a)
Species where no ortholog for NKX2-4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKX2-4 Gene

Gene Tree for NKX2-4 (if available)
Gene Tree for NKX2-4 (if available)

Paralogs for NKX2-4 Gene

(7) SIMAP similar genes for NKX2-4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX2-4: view

Variants for NKX2-4 Gene

Sequence variations from dbSNP and Humsavar for NKX2-4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000412367 -- 21,396,419(+) GAGCG(G/T)CTGCC upstream-variant-2KB, reference, missense
rs1000786079 -- 21,395,743(+) CTGTC(C/T)CCCGC upstream-variant-2KB, utr-variant-3-prime
rs1001710798 -- 21,397,642(+) TCTCG(-/C)CCCCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1002070964 -- 21,399,204(+) AACAT(A/C)AGTAT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1002138717 -- 21,397,782(+) TCCAT(C/T)CGCGG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NKX2-4 Gene

Variant ID Type Subtype PubMed ID
nsv1143980 CNV deletion 24896259
nsv828702 CNV gain 20364138
nsv833941 CNV gain 17160897

Variation tolerance for NKX2-4 Gene

Gene Damage Index Score: 0.55; 11.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKX2-4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX2-4 Gene

Disorders for NKX2-4 Gene

Relevant External Links for NKX2-4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NKX2-4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKX2-4 Gene

Publications for NKX2-4 Gene

  1. Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals. (PMID: 10818213) Wang CC … Harvey RP (Mammalian genome : official journal of the International Mammalian Genome Society 2000) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  3. Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. (PMID: 1346742) Price M … Di Lauro R (Neuron 1992) 2 3 60
  4. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung SA … International Consortium for Systemic Lupus Erythematosus Genetics (Journal of the American Society of Nephrology : JASN 2014) 3 60

Products for NKX2-4 Gene

Sources for NKX2-4 Gene

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