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Aliases for NKX2-4 Gene

Aliases for NKX2-4 Gene

  • NK2 Homeobox 4 2 3
  • NKX2D 3 4 6
  • NK2 Transcription Factor Related, Locus 4 (Drosophila) 2
  • NK2 Transcription Factor Related, Locus 4 3
  • NK2 Transcription Factor Homolog D 3
  • Homeobox Protein NK-2 Homolog D 4
  • NK-2 (Drosophila) Homolog D 2
  • Homeobox Protein Nkx-2.4 3
  • NKX2.4 3

External Ids for NKX2-4 Gene

Previous HGNC Symbols for NKX2-4 Gene

  • NKX2D

Previous GeneCards Identifiers for NKX2-4 Gene

  • GC20U990020
  • GC20M021324

Summaries for NKX2-4 Gene

GeneCards Summary for NKX2-4 Gene

NKX2-4 (NK2 Homeobox 4) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NKX2-5.

UniProtKB/Swiss-Prot for NKX2-4 Gene

  • Probable transcription factor

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX2-4 Gene

Genomics for NKX2-4 Gene

Regulatory Elements for NKX2-4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NKX2-4 Gene

Start:
21,395,367 bp from pter
End:
21,398,028 bp from pter
Size:
2,662 bases
Orientation:
Minus strand

Genomic View for NKX2-4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKX2-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX2-4 Gene

Proteins for NKX2-4 Gene

  • Protein details for NKX2-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2Z4-NKX24_HUMAN
    Recommended name:
    Homeobox protein Nkx-2.4
    Protein Accession:
    Q9H2Z4
    Secondary Accessions:
    • Q5VZV8

    Protein attributes for NKX2-4 Gene

    Size:
    354 amino acids
    Molecular mass:
    36179 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKX2-4 Gene

Proteomics data for NKX2-4 Gene at MOPED

Post-translational modifications for NKX2-4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKX2-4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX2-4 Gene

Domains for NKX2-4 Gene

Gene Families for NKX2-4 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for NKX2-4 Gene

Suggested Antigen Peptide Sequences for NKX2-4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2Z4

UniProtKB/Swiss-Prot:

NKX24_HUMAN :
  • Q9H2Z4
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the NK-2 homeobox family.
genes like me logo Genes that share domains with NKX2-4: view

Function for NKX2-4 Gene

Molecular function for NKX2-4 Gene

UniProtKB/Swiss-Prot Function: Probable transcription factor

Gene Ontology (GO) - Molecular Function for NKX2-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NKX2-4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NKX2-4 Gene

Localization for NKX2-4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX2-4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKX2-4 Gene COMPARTMENTS Subcellular localization image for NKX2-4 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for NKX2-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NKX2-4: view

Pathways for NKX2-4 Gene

SuperPathways for NKX2-4 Gene

No Data Available

Interacting Proteins for NKX2-4 Gene

Gene Ontology (GO) - Biological Process for NKX2-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NKX2-4: view

No data available for Pathways by source for NKX2-4 Gene

Transcripts for NKX2-4 Gene

mRNA/cDNA for NKX2-4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKX2-4 Gene

NK2 homeobox 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NKX2-4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NKX2-4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKX2-4 Gene

No ASD Table

Relevant External Links for NKX2-4 Gene

GeneLoc Exon Structure for
NKX2-4
ECgene alternative splicing isoforms for
NKX2-4

Expression for NKX2-4 Gene

mRNA expression in normal human tissues for NKX2-4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKX2-4 Gene

This gene is overexpressed in Testis (26.7), Brain - Hypothalamus (12.6), and Uterus (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NKX2-4 Gene

SOURCE GeneReport for Unigene cluster for NKX2-4 Gene Hs.456662

genes like me logo Genes that share expressions with NKX2-4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NKX2-4 Gene

Orthologs for NKX2-4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX2-4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKX2-4 35
  • 99.72 (n)
  • 99.72 (a)
NKX2-4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKX2-4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKX2-4 35
  • 88.96 (n)
  • 87.42 (a)
NKX2-4 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkx2-4 35
  • 90.38 (n)
  • 92.86 (a)
Nkx2-4 16
Nkx2-4 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKX2-4 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkx2-4 35
  • 89.88 (n)
  • 93.12 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nkx2-4 35
  • 68.23 (n)
  • 70 (a)
zebrafish
(Danio rerio)
Actinopterygii nkx2.1a 36
  • 69 (a)
OneToMany
zgc:171531 35
  • 66.56 (n)
  • 69.37 (a)
zgc:171531 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scro 35
  • 51.2 (n)
  • 56.54 (a)
scro 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-24 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CS-TTF1 36
  • 27 (a)
OneToMany
Species with no ortholog for NKX2-4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKX2-4 Gene

ENSEMBL:
Gene Tree for NKX2-4 (if available)
TreeFam:
Gene Tree for NKX2-4 (if available)

Paralogs for NKX2-4 Gene

Selected SIMAP similar genes for NKX2-4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX2-4: view

Variants for NKX2-4 Gene

Sequence variations from dbSNP and Humsavar for NKX2-4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs6035868 -- 21,395,188(+) TGATG(C/T)TGGGA downstream-variant-500B
rs6035869 -- 21,396,223(+) GCCGC(C/T)TTGTC synonymous-codon, reference
rs6047423 -- 21,395,271(+) TTTAG(C/G)GTAAC downstream-variant-500B
rs6137335 -- 21,397,869(+) GGCCC(C/T)TTCCA upstream-variant-2KB
rs8115033 -- 21,397,848(+) CTAGA(C/T)ATGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NKX2-4 Gene

Variant ID Type Subtype PubMed ID
nsv833941 CNV Gain 17160897
nsv828702 CNV Gain 20364138

Relevant External Links for NKX2-4 Gene

HapMap Linkage Disequilibrium report
NKX2-4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX2-4 Gene

Disorders for NKX2-4 Gene

No disorders were found for NKX2-4 Gene.

No data available for UniProtKB/Swiss-Prot for NKX2-4 Gene

Publications for NKX2-4 Gene

  1. Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2- 1/2-9 in mammals. (PMID: 10818213) Wang C.-C. … Harvey R.P. (Mamm. Genome 2000) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. (PMID: 1346742) Price M. … Di Lauro R. (Neuron 1992) 2 3
  4. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung S.A. … Langefeld C.D. (J. Am. Soc. Nephrol. 2014) 3

Products for NKX2-4 Gene

Sources for NKX2-4 Gene

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