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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKX2-3 Gene

protein-coding   GIFtS: 50
GCID: GC10P101292

NK2 homeobox 3

(Previous names: NK-2 (Drosophila) homolog C, NK2 transcription factor related,...)
(Previous symbol: NKX2C)
 Explore 9 diseases affiliated with
NKX2-3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NKX2-3    

Aliases
for NKX2-3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NK2 Homeobox 31 2     NK2.32 5
NKX2C1 2 3 5     NK-2 (Drosophila) Homolog C1
CSX31 2 5     NK2 Transcription Factor Related, Locus 3 (Drosophila)1
NKX2.31 2     Homeobox Protein Nkx-2.32
NKX4-31 2     NK2 Transcription Factor Related, Locus 32
Homeobox Protein NK-2 Homolog C2 3     NKX233

External Ids:    HGNC: 78361   Entrez Gene: 1592962   Ensembl: ENSG000001199197   OMIM: 6067275   UniProtKB: Q8TAU03   

Export aliases for NKX2-3 gene to outside databases

Previous GC identifers: GC10P100185 GC10P100526 GC10P101423 GC10P100957 GC10P101282 GC10P094918


Summaries
for NKX2-3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NKX2-3:
This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of
homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in
cellular differentiation.(provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: NKX23_HUMAN, Q8TAU0
Function: Transcription factor (By similarity)

Gene Wiki entry for NKX2-3


Genomic Views
for NKX2-3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKX2-3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   HSF2   E2F-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKX2-3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKX2-3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX2-3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.2   HGNC chromosome: 10

NKX2-3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKX2-3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P101292:  view genomic region     (about GC identifiers)

Start:
 101,292,690 bp from pter      End:
 101,296,281 bp from pter
Size:
 3,592 bases      Orientation:
 plus strand

Proteins
for NKX2-3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NKX23_HUMAN, Q8TAU0 (See protein sequence)
Recommended Name: Homeobox protein Nkx-2.3  
Size: 364 amino acids; 38406 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAH25788.1; Type=Frameshift; Positions=273; Note=This frameshift is potential, but if it is
real then the sequence of residues 274-302 are lacking from the translated cDNA while this region does not seem to
correspond to an exon;
Secondary accessions: B4DUZ4 Q9NYS6

Explore the universe of human proteins at neXtProt for NKX2-3: NX_Q8TAU0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TAU0

    • NKX2-3 Protein expression data from MOPED and PaxDb:    About this image 
    NKX2-3 Protein Expression
    REFSEQ proteins: NP_660328.2  
    ENSEMBL proteins: 
     ENSP00000342828  

    Human Recombinant Protein Products for NKX2-3: 
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    OriGene Protein Over-expression Lysate: NKX2-3
    OriGene Custom Protein Services for NKX2-3 
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    Novus Biologicals NKX2-3 Proteins
    Novus Biologicals NKX2-3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NKX2-3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    NKX2-3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NKX2-3

    Protein Domains /
    Families
    for NKX2-3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NKX2-3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_metazoa
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8TAU0

    ProtoNet protein and cluster: Q8TAU0

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: NKX23_HUMAN, Q8TAU0
    Similarity: Belongs to the NK-2 homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for NKX2-3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKX23_HUMAN, Q8TAU0
    Function: Transcription factor (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    NKX2-3 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nkx2-3):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     respiratory system 

    NKX2-3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Nkx2-3Nkx2-tm1Hha for NKX2-3
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NKX2-3 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NKX2-3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKX2-3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX2-3 (see all 11):
    hsa-miR-142-3p hsa-miR-205 hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-20b* hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NKX2-3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKX2-3
    OriGene shRNA RFP: NKX2-3
    OriGene siRNA: NKX2-3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX2-3
    Sirion Biotech Custom design and validation of potent shRNA sequences against NKX2-3 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NKX2-3
    Sirion Biotech Customized adenovirus for overexpression of NKX2-3 
    Sirion Biotech Customized adenovirus for potent knockdown of NKX2-3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-3
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-3 (see all 2)
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    GenScript: all cDNA clones in your preferred vector: NKX2-3 (NM_145285)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX2-3 

    Cell Line
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    Search LifeMap BioReagents cell lines for NKX2-3
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-3


    Pathways & Interactions
    for NKX2-3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKX2-3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for NKX2-3 (Q8TAU03 ENSP000003428284) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    SRFP118313, ENSP000002653544I2D: score=1 STRING: ENSP00000265354
    ZNF212Q9UDV63, ENSP000003385724I2D: score=1 STRING: ENSP00000338572
    CDX1P479023I2D: score=1 
    TLE3Q047263I2D: score=1 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001776leukocyte homeostasis IEA--
    GO:0002317plasma cell differentiation IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006641triglyceride metabolic process IEA--
    GO:0006955immune response ----

    NKX2-3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NKX2-3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKX2-3
    Search CenterWatch for drugs/clinical trials and news about NKX2-3 / NKX23 

    Transcripts
    for NKX2-3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NKX2-3 gene: 
    NM_145285.2  

    Unigene Cluster for NKX2-3:

    NK2 homeobox 3
    Hs.243272  [show with all ESTs]
    Unigene Representative Sequence: NM_145285
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000344586(uc009xwj.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NKX2-3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKX2-3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate NKX2-3 (see all 11):
    hsa-miR-142-3p hsa-miR-205 hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-20b* hsa-miR-486-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NKX2-3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKX2-3
    OriGene shRNA RFP: NKX2-3
    OriGene siRNA: NKX2-3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX2-3
    Sirion Biotech Custom design and validation of potent shRNA sequences against NKX2-3 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-3
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKX2-3 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NKX2-3 (NM_145285)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKX2-3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKX2-3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NKX2-3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NKX2-3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX2-3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX2-3

    Additional cDNA sequence: 

    AK300856.1 AK313485.1 BC025788.1 

    1 DOTS entry:

    DT.75140288 

    7 AceView cDNA sequences:

    BC025788 NM_145285 BI764885 AW074707 BI765919 BI837145 BI833798 

    GeneLoc Exon Structure


    Expression
    for NKX2-3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKX2-3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGAGAGAA
    NKX2-3 Expression
    About this image

    NKX2-3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    BoneMandibular ProcessBone
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    Primitive gut tube-like cells (A scalable, suspensi...)

    See NKX2-3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKX2-3

    SOURCE GeneReport for Unigene cluster: Hs.243272
        SABiosciences Custom PCR Arrays for NKX2-3
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKX2-3

    Orthologs
    for NKX2-3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NKX2-3 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia NKX2-36
    		 --
    		 85(a)
    		 1 ↔ 1
    		 3(38400551-38400946)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.10462 Xenopus laevis XNkx-2.3 (allele XNkx-2.3b1) mRNA, complete more 79.71(n)    L38675.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii NM_131419.12   -- 76.29(n)   30694  NM_131419.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta tin6
    		 tinman
    		 17(a)
    		 1 → many
    		 3R(17204701-17207692)
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-286
    		 Homeobox family member (ceh-28)
    		 26(a)
    		 1 → many
    		 X(13074613-13076023)


    ENSEMBL Gene Tree for NKX2-3 (if available)
    TreeFam Gene Tree for NKX2-3 (if available) 

    Paralogs
    for NKX2-3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKX2-3 gene
    NKX2-12  HMX32  LBX22  TLX22  NKX3-12  TLX12  HMX22  NKX3-22  
    NKX2-62  NKX2-82  NKX2-52  LBX12  NKX2-22  NKX2-42  HMX12  TLX32  
    6 SIMAP similar genes for NKX2-3 using alignment to 1 protein entry:     NKX23_HUMAN:
    NKX2-5    HLX    NKX2-4    NKX2-8    NKX2-6    NKX2-2

    NKX2-3 for paralogs           About GeneDecksing



    Genomic Variants
    for NKX2-3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/100 NCBI SNPs in NKX2-3 are shown (see all 100)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs99194901,2
    		C--94917324(+) TGCGGG/TACCCG 1 -- us2k10--------
    rs580314241,2
    		C--94917845(+) TCACCC/TCCCTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1139029001,2
    		--94917986(+) AGGCCG/CTGCAC 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1161665591,2
    		C,F--94918484(+) GGACAT/CGNNNN 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs770507871,2
    		C--94919225(+) GCACCA/CCTTCC 2 H P mis10--------
    rs1131546881,2
    		--94919974(+) GGCCAA/GCTGGG 1 -- int10--------
    rs122473681,2
    		C,F--94920851(+) CAGCCA/CTTTAC 1 -- int11Minor allele frequency- C:0.05WA 118
    rs790119701,2
    		C--94920927(+) CCGGGA/GACAGC 1 -- int10--------
    rs1998638321,2
    		C--94921877(-) TCCTCC/TTNNNN 1 -- ut310--------
    rs79064961,2
    		C,F--94922154(+) ACCGAT/CCCTCT 1 -- ut31 ese31Minor allele frequency- C:0.05WA 118

    HapMap Linkage Disequilibrium report for NKX2-3 (101292690 - 101296281 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NKX2-3: --
    Human Gene Mutation Database (HGMD): NKX2-3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKX2-3
    DNA2.0 Custom Variant and Variant Library Synthesis for NKX2-3

    Disorders / Diseases
    for NKX2-3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NKX2-3 for disorders           About GeneDecksing

    OMIM gene information: 606727    OMIM disorders: --

    9 diseases for NKX2-3:    About MalaCards
    ankylosing spondylitis    inflammatory bowel disease    ulcerative colitis    spondylitis
    celiac disease    crohn's disease    alzheimer's disease    pharyngitis
    colorectal cancer

    2 diseases from the University of Copenhagen DISEASES database for NKX2-3:
    Crohn's disease     Ulcerative colitis
    Human Genome Epidemiology (HuGE) Navigator: NKX2-3 (17 documents)

    Export disorders for NKX2-3 gene to outside databases

    Publications
    for NKX2-3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKX2-3 gene, integrated from 9 sources (see all 38) (see top 10):
    (articles sorted by number of sources associating them with NKX2-3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. PTPN2 is associated with Crohn's disease and its expre ssion is regulated by NKX2-3. (PubMed id 22377701)1 Yu W....Lin Z. (2012)
    4. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
    5. Genes differentially regulated by NKX2-3 in B cells be tween ulcerative colitis and Crohn's disease patients and possible involvement o f EGR1. (PubMed id 21968973)1 Yu W....Koltun W.A. (2012)
    6. Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa. (PubMed id 21514341)1 Arai T....Shimosegawa T. (2011)
    7. NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT. (PubMed id 21803625)1 John G....Lin Z. (2011)
    8. NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells. (PubMed id 21637825)1 Yu W....Lin Z. (2011)
    9. Association between genome-wide association studies r eported SNPs and pediatric-onset Crohn's disease in Canadian children. (PubMed id 20473688)1 Amre D.K....Levy E. (2010)
    10. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PubMed id 20228798)1 Franke A....Vatn M.H. (2010)
    11. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    12. Genetic analysis in a Dutch study sample identifies m ore ulcerative colitis susceptibility loci and shows their additive role in dis ease risk. (PubMed id 19861958)1 Festen E.A....Weersma R.K. (2010)
    13. Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis. (PubMed id 21072187)1 Laukens D....De Vos M. (2010)
    14. Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)1 McGovern D.P....Weersma R.K. (2010)
    15. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1 Franke A....Parkes M. (2010)
    16. Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel disease. (PubMed id 20188614)1 Yu W....Koltun W.A. (2010)
    17. Analysis of 39 Crohn's disease risk loci in Swedish i nflammatory bowel disease patients. (PubMed id 19760754)1 TAPrkvist L....Pettersson S. (2010)
    18. Genes regulated by Nkx2-3 in sporadic and inflammator y bowel disease-associated colorectal cancer cell lines. (PubMed id 20165982)1 Yu W....Koltun W.A. (2010)
    19. Molecular reclassification of Crohn's disease by clus ter analysis of genetic variants. (PubMed id 20886065)1 Cleynen I....Vermeire S. (2010)
    20. NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients. (PubMed id 21049557)1 Meggyesi N....Lakatos P.L. (2010)
    21. Lack of association of NKX2-3, IRGM, and ATG16L1 infl ammatory bowel disease susceptibility variants with celiac disease. (PubMed id 19683022)1 Dema B....NA_A+ez C. (2009)
    22. Genetic Risk Profiling And Prediction Of Disease Course In Crohn'S Disease Patients. (PubMed id 19422935)1 Henckaerts L....Vermeire S. (2009)
    23. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1 Weersma R.K....Vermeire S. (2009)
    24. Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. (PubMed id 18936107)1 Yamazaki K....Hata A. (2008)
    25. A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PubMed id 18255255)1 Gao J....Yu Y. (2008)
    26. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. (PubMed id 18438406)1 Fisher S.A....Satsangi J. (2008)
    27. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. (PubMed id 18587394)1 Barrett J.C....Daly M.J. (2008)
    28. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. (PubMed id 18438405)1 Franke A....Schreiber S. (2008)
    29. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1  . (2007)
    30. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. (PubMed id 17554261)1 Parkes M....Mathew C.G. (2007)
    31. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
    32. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    33. NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis. (PubMed id 12141427)1 Biben C....Harvey R.P. (2002)
    34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    35. Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues. (PubMed id 11457859)1 Phiel C.J....McHugh K.M. (2001)
    36. The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development. (PubMed id 9142493)3 Pabst O....Arnold H.H. (1997)

    External Searches for NKX2-3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NKX2-3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 159296 HGNC: 7836 AceView: NKX2-3 Ensembl:ENSG00000119919 euGenes: HUgn159296
    ECgene: NKX2-3 H-InvDB: NKX2-3

    Other Databases showing NKX2-3 gene

    (According to HUGE)
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    Specialized Databases showing NKX2-3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKX2-3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NKX2-3 gene:
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