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Aliases for NKX1-2 Gene

Aliases for NKX1-2 Gene

  • NK1 Homeobox 2 2 3 5
  • Homeobox Protein SAX-1 3 4
  • C10orf121 3 4
  • NKX-1.1 3 4
  • NK1 Transcription Factor Related, Locus 2 (Drosophila) 2
  • NK1 Transcription Factor Related, Locus 2 3
  • Chromosome 10 Open Reading Frame 121 2
  • BB238F13.2 3
  • NKX1.1 4

External Ids for NKX1-2 Gene

Previous HGNC Symbols for NKX1-2 Gene

  • C10orf121

Previous GeneCards Identifiers for NKX1-2 Gene

  • GC10M126127
  • GC10M119820
  • GC10M126135

Summaries for NKX1-2 Gene

GeneCards Summary for NKX1-2 Gene

NKX1-2 (NK1 Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD3.

UniProtKB/Swiss-Prot for NKX1-2 Gene

  • May function in cell specification, particularly in the CNS.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX1-2 Gene

Genomics for NKX1-2 Gene

Regulatory Elements for NKX1-2 Gene

Enhancers for NKX1-2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NKX1-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NKX1-2 Gene

124,445,239 bp from pter
124,450,184 bp from pter
4,946 bases
Minus strand

Genomic View for NKX1-2 Gene

Genes around NKX1-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKX1-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKX1-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX1-2 Gene

Proteins for NKX1-2 Gene

  • Protein details for NKX1-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NK1 transcription factor-related protein 2
    Protein Accession:

    Protein attributes for NKX1-2 Gene

    310 amino acids
    Molecular mass:
    32381 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKX1-2 Gene

Proteomics data for NKX1-2 Gene at MOPED

Post-translational modifications for NKX1-2 Gene

No Post-translational modifications

Other Protein References for NKX1-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX1-2 Gene

Domains & Families for NKX1-2 Gene

Gene Families for NKX1-2 Gene

Protein Domains for NKX1-2 Gene

Suggested Antigen Peptide Sequences for NKX1-2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the NK-1 homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the NK-1 homeobox family.
genes like me logo Genes that share domains with NKX1-2: view

Function for NKX1-2 Gene

Molecular function for NKX1-2 Gene

UniProtKB/Swiss-Prot Function:
May function in cell specification, particularly in the CNS.

Gene Ontology (GO) - Molecular Function for NKX1-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NKX1-2: view

Animal Model Products

CRISPR Products

miRNA for NKX1-2 Gene

miRTarBase miRNAs that target NKX1-2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKX1-2 Gene

Localization for NKX1-2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX1-2 Gene

Subcellular locations from

Jensen Localization Image for NKX1-2 Gene COMPARTMENTS Subcellular localization image for NKX1-2 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for NKX1-2 Gene

Pathways & Interactions for NKX1-2 Gene

SuperPathways for NKX1-2 Gene

No Data Available

Interacting Proteins for NKX1-2 Gene

Gene Ontology (GO) - Biological Process for NKX1-2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NKX1-2 Gene

Drugs & Compounds for NKX1-2 Gene

No Compound Related Data Available

Transcripts for NKX1-2 Gene

mRNA/cDNA for NKX1-2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKX1-2 Gene

NK1 homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKX1-2 Gene

No ASD Table

Relevant External Links for NKX1-2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKX1-2 Gene

mRNA expression in normal human tissues for NKX1-2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKX1-2 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.7), Brain - Nucleus accumbens (basal ganglia) (x6.2), Brain - Putamen (basal ganglia) (x5.4), and Brain - Frontal Cortex (BA9) (x4.2).

SOURCE GeneReport for Unigene cluster for NKX1-2 Gene Hs.712041

genes like me logo Genes that share expression patterns with NKX1-2: view

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NKX1-2 Gene

Orthologs for NKX1-2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX1-2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NKX1-2 35
  • 80.43 (n)
  • 75.34 (a)
NKX1-2 36
  • 76 (a)
(Canis familiaris)
Mammalia NKX1-2 35
  • 83.67 (n)
  • 80.54 (a)
NKX1-2 36
  • 79 (a)
(Mus musculus)
Mammalia Nkx1-2 35
  • 76.38 (n)
  • 74.17 (a)
Nkx1-2 16
Nkx1-2 36
  • 75 (a)
(Pan troglodytes)
Mammalia NKX1-2 35
  • 98.82 (n)
  • 98.06 (a)
(Rattus norvegicus)
Mammalia Nkx1-2 35
  • 75.61 (n)
  • 73.84 (a)
(Monodelphis domestica)
Mammalia NKX1-2 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia NKX1-2 36
  • 57 (a)
(Gallus gallus)
Aves NKX1-2 35
  • 75.41 (n)
  • 75.89 (a)
NKX1-2 36
  • 48 (a)
(Anolis carolinensis)
Reptilia NKX1-2 36
  • 51 (a)
(Danio rerio)
Actinopterygii nkx1.2la 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta slou 36
  • 15 (a)
Species with no ortholog for NKX1-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKX1-2 Gene

Gene Tree for NKX1-2 (if available)
Gene Tree for NKX1-2 (if available)

Paralogs for NKX1-2 Gene

(6) SIMAP similar genes for NKX1-2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NKX1-2: view

Variants for NKX1-2 Gene

Sequence variations from dbSNP and Humsavar for NKX1-2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3851562 -- 124,448,234(-) GGGTT(A/G/T)GGGGG intron-variant
rs3851563 -- 124,448,242(-) CCAGA(C/G)TTGGG intron-variant
rs3916136 -- 124,448,113(-) TCCCG(C/G)CTGGA reference, synonymous-codon
rs3926050 -- 124,448,867(-) GGCCC(A/G)GGCAG intron-variant
rs4144118 -- 124,450,408(+) GCCAG(G/T)ACTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NKX1-2 Gene

Variant ID Type Subtype PubMed ID
nsv832012 CNV Gain+Loss 17160897

Variation tolerance for NKX1-2 Gene

Gene Damage Index Score: 6.65; 78.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NKX1-2 Gene

Disorders for NKX1-2 Gene

Relevant External Links for NKX1-2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NKX1-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKX1-2 Gene

Publications for NKX1-2 Gene

  1. The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites. (PMID: 10681422) Rovescalli A.C. … Nirenberg M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 67
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for NKX1-2 Gene

Sources for NKX1-2 Gene