NKX1-1 Gene
protein-coding GIFtS: 29
GCID: GC04M001380 (predicted)
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NK1 homeobox 1(Previous names: NK1 transcription factor related, locus 1 (Drosophila)...)
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Aliases
for NKX1-1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NK1 Homeobox 11 2 | | NK1 Transcription Factor Related, Locus 1 (Drosophila)1 | | HSPX1531 2 | | HPX-153 Homeobox2 | | SAX21 2 | | NK1 Transcription Factor Related, Locus 12 | | Homeobox Protein 1532 3 | | NK1 Transcription Factor-Related Protein 12 | | Homeobox Protein SAX-22 3 | | HPX-1533 | | NKX-1.12 3 | | HPX1533 |
Export aliases for NKX1-1 gene to outside databasesPrevious GC identifer: GC04U900463 |
Summaries
for NKX1-1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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-- |
Genomic Views
for NKX1-1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NKX1-1 gene promoter:
NCX/Ncx MyoD Evi-1 S8 POU2F1 POU2F1b POU2F1a Sox9 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for NKX1-1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX1-1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3NKX1-1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M001380: view genomic region
(about GC identifiers)
Start:
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1,396,720 bp from pter |
End:
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1,400,119 bp from pter |
Size:
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3,400 bases |
Orientation:
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minus strand |
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Proteins
for NKX1-1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: NKX11_HUMAN, Q15270 (See
protein sequence)Recommended Name: NK1 transcription factor-related protein 1 Size: 411 amino acids; 40659 Da
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for NKX1-1: NX_Q15270
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15270
NKX1-1 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000407978
Human Recombinant Protein Products for NKX1-1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
NAS | -- |
NKX1-1 for ontologies About GeneDecksing
NKX1-1 Antibody Products:
Assay Products for NKX1-1: |
Protein
Domains /
Families
for NKX1-1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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NKX1-1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15270ProtoNet protein and cluster: Q15270 UniProtKB/Swiss-Prot: NKX11_HUMAN, Q15270Similarity: Belongs to the NK-1 homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for NKX1-1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003677 | DNA binding |
NAS | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
NKX1-1 for ontologies About GeneDecksing
Animal Models:
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Pathways & Interactions
for NKX1-1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKX1-1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for NKX1-1 (Q152703 ENSP000004079784) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0043467 | regulation of generation of precursor metabolites and energy |
IEA | -- | | GO:0050877 | neurological system process |
IEA | -- |
NKX1-1 for ontologies About GeneDecksing
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Drugs & Compounds
for NKX1-1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for NKX1-1
Search CenterWatch for drugs/clinical trials and news about NKX1-1 / NKX11 
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Transcripts
for NKX1-1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for NKX1-1: NK1 homeobox 1 Hs.526396 Unigene Representative Sequence: X769781 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000422806
Additional cDNA sequence: X76978.1
GeneLoc Exon Structure
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Expression
for NKX1-1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NKX1-1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NKX1-1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NKX1-1
SOURCE GeneReport for Unigene cluster: Hs.526396
UniProtKB/Swiss-Prot: NKX11_HUMAN, Q15270Tissue specificity: Expressed in hemopoietic progenitor cells
SABiosciences Custom PCR Arrays for NKX1-1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NKX1-1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX1-1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX1-1 |
Orthologs
for NKX1-1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for NKX1-1 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
NKX1-16 |
-- |
49(a) |
1 ↔ 1 |
GL343447.1(272608-279415) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.258512 |
Xenopus laevis nbx mRNA for NK-1 related homeobox protein Nbx, complete cds less |
79.07(n) |
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AB103111.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
pnx2 |
posterior neuron-specific homeobox |
77.36(n) |
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352939 AB067731.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
slou6lms6 |
lateral muscles scarcer |
14(a)11(a) |
1 ↔ 1possible ortholog |
3R(17374377-17383004) 2R(16444364-16447458) |
ENSEMBL Gene Tree for NKX1-1 (if available)
TreeFam Gene Tree for NKX1-1 (if available) |
Paralogs
for NKX1-1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NKX1-1 gene
- NKX1-22 MEOX12 EVX12 MNX12 MEOX22 EVX22 GBX12 GBX22
6 SIMAP similar genes for NKX1-1 using alignment to 1 protein entry: NKX11_HUMAN:NKX6-1 HMX2 DLX6 HOXB1 NKX1-2 homeobox gene
NKX1-1 for paralogs About GeneDecksing
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Genomic Variants
for NKX1-1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for NKX1-1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for NKX1-1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for NKX1-1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NKX1-1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of homeobox genes expressed in human haemopoietic progenitor cells. (PubMed id 7518789)1, 2, 3 Moretti P....D'Andrea R. (1994)
- A pharmacokinetic PET study of NK_1 receptor occupancy . (PubMed id 21993526)1 Zamuner S....Cunningham V.J. (2012)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
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External Searches for NKX1-1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NKX1-1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing NKX1-1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NKX1-1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NKX1-1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NKX1-1 gene:
Search GeneIP for patents involving NKX1-1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NKX1-1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NKX1-1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKX1-1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKX1-1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKX1-1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKX1-1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKX1-1 |
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| | | | Search Tocris compounds for NKX1-1 |
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 | | | NKX1-1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for NKX1-1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NKX1-1 |
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