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Aliases for NKX1-1 Gene

Aliases for NKX1-1 Gene

  • NK1 Homeobox 1 2 3
  • Homeobox Protein SAX-2 3 4
  • Homeobox Protein 153 3 4
  • NKX-1.1 3 4
  • NK1 Transcription Factor Related, Locus 1 (Drosophila) 2
  • NK1 Transcription Factor-Related Protein 1 3
  • NK1 Transcription Factor Related, Locus 1 3
  • HPX-153 Homeobox 3
  • HSPX153 3
  • HPX-153 4
  • HPX153 4
  • SAX2 3

External Ids for NKX1-1 Gene

Previous GeneCards Identifiers for NKX1-1 Gene

  • GC04U900463
  • GC04M001380

Summaries for NKX1-1 Gene

GeneCards Summary for NKX1-1 Gene

NKX1-1 (NK1 Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DLX5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX1-1 Gene

Genomics for NKX1-1 Gene

Regulatory Elements for NKX1-1 Gene

Genomic Location for NKX1-1 Gene

1,402,932 bp from pter
1,406,331 bp from pter
3,400 bases
Minus strand

Genomic View for NKX1-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKX1-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX1-1 Gene

Proteins for NKX1-1 Gene

  • Protein details for NKX1-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NK1 transcription factor-related protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for NKX1-1 Gene

    411 amino acids
    Molecular mass:
    40659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKX1-1 Gene

Proteomics data for NKX1-1 Gene at MOPED

Post-translational modifications for NKX1-1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKX1-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX1-1 Gene

Domains for NKX1-1 Gene

Gene Families for NKX1-1 Gene

  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for NKX1-1 Gene

Suggested Antigen Peptide Sequences for NKX1-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q15270
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the NK-1 homeobox family.
genes like me logo Genes that share domains with NKX1-1: view

Function for NKX1-1 Gene

Gene Ontology (GO) - Molecular Function for NKX1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NKX1-1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NKX1-1 Gene

Localization for NKX1-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX1-1 Gene

Subcellular locations from

Jensen Localization Image for NKX1-1 Gene COMPARTMENTS Subcellular localization image for NKX1-1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NKX1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NKX1-1: view

Pathways for NKX1-1 Gene

SuperPathways for NKX1-1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKX1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006629 lipid metabolic process IEA --
GO:0008150 biological_process ND --
GO:0010906 regulation of glucose metabolic process IEA --
GO:0043467 regulation of generation of precursor metabolites and energy IEA --
genes like me logo Genes that share ontologies with NKX1-1: view

No data available for Pathways by source for NKX1-1 Gene

Transcripts for NKX1-1 Gene

mRNA/cDNA for NKX1-1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NKX1-1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKX1-1 Gene

No ASD Table

Relevant External Links for NKX1-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKX1-1 Gene

mRNA expression in normal human tissues for NKX1-1 Gene

mRNA differential expression in normal tissues according to GTEx for NKX1-1 Gene

This gene is overexpressed in Testis (40.0) and Pituitary (11.3).

Protein differential expression in normal tissues for NKX1-1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NKX1-1 Gene

SOURCE GeneReport for Unigene cluster for NKX1-1 Gene Hs.526396

mRNA Expression by UniProt/SwissProt for NKX1-1 Gene

Tissue specificity: Expressed in hemopoietic progenitor cells.
genes like me logo Genes that share expressions with NKX1-1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NKX1-1 Gene

Orthologs for NKX1-1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX1-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 29 (a)
(Canis familiaris)
Mammalia NKX1-1 36
  • 88 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
(Mus musculus)
Mammalia Nkx1-1 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia NKX1-1 36
  • 49 (a)
(Pan troglodytes)
Mammalia NKX1-1 36
  • 62 (a)
(Gallus gallus)
Aves NKX1-1 36
  • 53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25851 35
(Danio rerio)
Actinopterygii pnx 35
nkx1.2lb 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea ceh-1 36
  • 48 (a)
Species with no ortholog for NKX1-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKX1-1 Gene

Gene Tree for NKX1-1 (if available)
Gene Tree for NKX1-1 (if available)

Paralogs for NKX1-1 Gene

Selected SIMAP similar genes for NKX1-1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX1-1: view

Variants for NKX1-1 Gene

Sequence variations from dbSNP and Humsavar for NKX1-1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs11248002 -- 1,404,447(+) AGCCC(A/C)GGCTC intron-variant
rs11731672 -- 1,405,109(+) GCCCT(C/T)CATCT intron-variant
rs11945310 -- 1,403,509(+) GGCCC(G/T)GGGCA reference, missense
rs13120467 -- 1,406,219(+) GGGGC(A/G)CTGCG reference, missense
rs13121529 -- 1,405,992(+) CTCAG(A/C)TCCGG reference, missense

Relevant External Links for NKX1-1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NKX1-1 Gene

Disorders for NKX1-1 Gene

No disorders were found for NKX1-1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NKX1-1 Gene

Publications for NKX1-1 Gene

  1. Identification of homeobox genes expressed in human haemopoietic progenitor cells. (PMID: 7518789) Moretti P. … D'Andrea R. (Gene 1994) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for NKX1-1 Gene

Sources for NKX1-1 Gene

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