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Aliases & Descriptions for NKTR
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp686F1754 2 | | DKFZp686G0426 2 | | DKFZp686J06106 2 | | DKFZp686N24126 2 | | MGC90527 2 | | p104 1, 2 |
| | | Descriptions |
|---|
| NK-TR protein 2, 3 | | NK-tumor recognition protein 2 | | Natural-killer cells cyclophilin-related protein 2, 3 | | natural killer triggering receptor 2 | | natural killer-tumor recognition sequence 2 |
|
| | Search outside databases for aliases for NKTR genePrevious GC identifers: GC03P041946 GC03P041822 GC03P042461 GC03P042602 |
Summaries for NKTR(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NKTR: This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq] UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414Function: Component of a putative tumor-recognition complex. Involved in the function of NK cellsGene Wiki entry for NKTR |
Genomic Location for NKTR
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NKTR gene 
Entrez Gene cytogenetic band: 3p23-p21 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p23-p21NKTR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P042617:
(about GC identifiers)
Start:
|
42,617,151 bp from pter |
End:
|
42,665,237 bp from pter |
Size:
|
48,087 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for NKTR
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414 (See
protein sequence)Recommended Name: NK-tumor recognition protein Size: 1462 amino acids; 165677 Da
Subcellular location: Membrane; Peripheral membrane protein. Note=Attached to the membrane via its N-terminus
PDB structures from and Proteopedia :2HE9 (3D)
 Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005376.2
ENSEMBL proteins: ENSP00000373255 ENSP00000232978
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | About this table
Antibodies for NKTR: Assays for NKTR: | Protein
Domains/ Families for NKTR(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P30414
ProtoNet protein and cluster: P30414 1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase
UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414Similarity: Contains 1 PPIase cyclophilin-type domain | Gene Function for NKTR
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005385
Applied Biosystems Silencer® siRNAs for NKTR
Sigma-Aldrich siRNA for NKTR  Sigma-Aldrich shRNA for NKTR  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005385                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005385                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001012651 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005385
UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414Function: Component of a putative tumor-recognition complex. Involved in the function of NK cellsGenatlas biochemistry entry for NKTR:natural killer triggering receptor1 MGI phenotypic allele for Nktr (no phenotypes)
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for NKTR
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for NKTR (ENSP000002329783) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- | About this table
|
Drugs & Compounds for NKTR(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NKTR
|
Transcripts for NKTR(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005385
Sigma-Aldrich siRNA for NKTR  Sigma-Aldrich shRNA for NKTR  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005385 REFSEQ mRNAs for NKTR gene: NM_005385.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005385               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005385                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005385                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001012651  Additional cDNA sequence: AK093752.1 BC020672.1 BC144518.1 L04288.2 S65996.1 24/30 DOTS entries (see all 30
): DT.120783 DT.65284018 DT.95342764 DT.99978093 DT.75167322 DT.448662 DT.40117505 DT.120780 DT.91698317 DT.85104310 DT.87046221 DT.40312655 DT.100642471 DT.120784 DT.92428429 DT.120908207 DT.100686840 DT.120908157 DT.120908170 DT.120908206 DT.86854098 DT.86859540 DT.100774721 DT.120908107 24/417 AceView cDNA sequences (see all 417
):AI921190 BU683985 BC020672 AA490321 AI393950 NM_005385 BM971532 AA825713 AA490422 AI241849 BM263875 AU134460 AA989253 N87819 BX953963 S65996 CB122574 AA766469 AA279666 AA418204 AI638583 AI753079 BU172607 AW243396
highest scoring ESTs for NKTR:AI698820 L04288 AA013468 AA047834 AA855031 AW117469 AW627789 BE709393 BF221969 BF344230 Unigene Cluster for NKTR: Natural killer-tumor recognition sequence Hs.529509 [show with all ESTs]Unigene Representative Sequence: NM_005385
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NKTR (see all 11
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | |
| SP1: | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |
| SP3: | - |   | |   | |   | |   | |   | |
| SP4: | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NKTR
2 Ensembl transcripts including schematic representations: ENST00000383749
ENST00000232978
|
Expression for NKTR
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NKTR expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NKTR
1 / 2 / 3 17 probe-sets matching NKTR gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAAAAGGACA
SOURCE GeneReport for Unigene cluster: Hs.529509
Expression variation in blood from EXPOLDB for NKTR |
Orthologs for NKTR
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NKTR gene from 5/7 species (see all 7
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
mouse (Mus musculus) |
Nktr1, 5 |
9 (71.00 cM)5
|
natural killer tumor recognition sequence1, 5 |
81.81(n)1 79.83(a)1 |
180871 NM_010918.21 NP_035048.31 AI4654025 AI8470655 (see all 19) |
zebrafish (Danio rerio) |
nktr1 |
-- |
natural killer-tumor recognition sequence |
53.67(n) 49.18(a) |
323005 XM_001338036.2 XP_001338072.2 |
worm (Caenorhabditis elegans) |
cyp-83 |
X(8946628-8949076) |
Expression: intestine, pharynx, embryo, L1 larva, more |
56(a) |
-- |
African clawed frog (Xenopus laevis) |
BJ619911.12 |
-- |
-- |
77.09(n) |
BJ619911.1 |
tropical clawed frog (Silurana tropicalis) |
BX727354.12 |
-- |
-- |
73.62(n) |
BX727354.1 |
About this table Species with no ortholog for NKTR
ENSEMBL Gene Tree for NKTR | Paralogs for NKTR(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NKTR gene
- PPIL62 PPIL42
|
SNPs/Variants for NKTR(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NKTR (up to first 250kb)
|
Disorders & Mutations for NKTR
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 161565
|
Medical News for NKTR(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NKTR (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for NKTR gene (see all 13
): |
Search for NKTR
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NKTR
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NKTR
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NKTR(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NKTR(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NKTR:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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