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NKTR Gene

protein-coding   GIFtS: 57

GC03P042617
natural killer-tumor recognition sequence
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp686F1754 2
DKFZp686G0426 2
DKFZp686J06106 2
DKFZp686N24126 2
MGC90527 2
p104 1, 2
Descriptions
NK-TR protein 2, 3
NK-tumor recognition protein 2
Natural-killer cells cyclophilin-related protein 2, 3
natural killer triggering receptor 2
natural killer-tumor recognition sequence 2
External Ids
HGNC: 78331
Entrez Gene: 48202
UniProtKB: P304143
Ensembl: ENSG000001148577
Search outside databases for aliases for NKTR gene

Previous GC identifers: GC03P041946 GC03P041822 GC03P042461 GC03P042602

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for NKTR:
This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a
cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and
facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells.
[provided by RefSeq]

UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414
Function: Component of a putative tumor-recognition complex. Involved in the function of NK cells

Gene Wiki entry for NKTR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NKTR gene  

Entrez Gene cytogenetic band: 3p23-p21   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p23-p21

NKTR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P042617:     (about GC identifiers)

Start:
42,617,151 bp from pter
End:
42,665,237 bp from pter
Size:
48,087 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000003.10  NT_022517.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414 (See protein sequence)
Recommended Name: NK-tumor recognition protein  
Size: 1462 amino acids; 165677 Da
Subcellular location: Membrane; Peripheral membrane protein. Note=Attached to the membrane via its
N-terminus
PDB structures from and Proteopedia :
2HE9 (3D)    

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005376.2  

    ENSEMBL proteins: 
    ENSP00000373255 ENSP00000232978 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (NKTR)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    About this table

    Antibodies for NKTR: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NKTR
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for NKTR

    Assays for NKTR: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR002130 PPIase_cyclophilin


       GeneDecks  NKTR for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P30414

    ProtoNet protein and cluster: P30414

    1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414
    Similarity: Contains 1 PPIase cyclophilin-type domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NKTR)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005385

                  Applied Biosystems Silencer® siRNAs for NKTR

                  Sigma-Aldrich siRNA for NKTR  
                         Sigma-Aldrich shRNA for NKTR  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005385
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005385
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001012651 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005385

    UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414
    Function: Component of a putative tumor-recognition complex. Involved in the function of NK cells

    Genatlas biochemistry entry for NKTR:
    natural killer triggering receptor
    1 MGI phenotypic allele for Nktr (no phenotypes)

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0016018 cyclosporin A binding TAS8421688
    GO:0016853 isomerase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for NKTR (ENSP000002329783) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARVAENSP000003340083STRING (score=.726)
    --ENSP000003485873STRING (score=.807)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457 protein folding IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for NKTR

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NKTR)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005385

                  Sigma-Aldrich siRNA for NKTR  
                         Sigma-Aldrich shRNA for NKTR  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005385  

    REFSEQ mRNAs for NKTR gene: 

    NM_005385.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005385  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005385
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005385
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001012651 

    Additional cDNA sequence: 

    AK093752.1 BC020672.1 BC144518.1 L04288.2 S65996.1 

    24/30 DOTS entries (see all 30 ):

    DT.120783  DT.65284018  DT.95342764  DT.99978093  DT.75167322  DT.448662  DT.40117505  DT.120780 
    DT.91698317  DT.85104310  DT.87046221  DT.40312655  DT.100642471  DT.120784  DT.92428429  DT.120908207 
    DT.100686840  DT.120908157  DT.120908170  DT.120908206  DT.86854098  DT.86859540  DT.100774721  DT.120908107 

    24/417 AceView cDNA sequences (see all 417 ):

    AI921190 BU683985 BC020672 AA490321 AI393950 NM_005385 BM971532 AA825713 
    AA490422 AI241849 BM263875 AU134460 AA989253 N87819 BX953963 S65996 
    CB122574 AA766469 AA279666 AA418204 AI638583 AI753079 BU172607 AW243396 

    highest scoring ESTs for NKTR:

    AI698820 L04288 AA013468 AA047834 AA855031 AW117469 AW627789 BE709393 BF221969 BF344230 

    Unigene Cluster for NKTR:

    Natural killer-tumor recognition sequence
    Hs.529509  [show with all ESTs]
    Unigene Representative Sequence: NM_005385


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NKTR (see all 11 )

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
    SP1:                          -                 -           -                                                                                                   
    SP2:                                                                                                  -                 -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 17a · 17b ^ 18a · 18b · 18c
    SP1:                              
    SP2:                              
    SP3:  -                           
    SP4:  -                           
    SP5:                              

    About this scheme

    ECgene alternative splicing isoforms for NKTR

    2 Ensembl transcripts including schematic representations:
    ENST00000383749  ENST00000232978  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NKTR expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NKTR

    1 / 2 / 3

    17 probe-sets matching NKTR gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    66050_at2, 3 U95-C 1 1.00 1.00 0.86 1.24 AI698820 1.00 1.00 1.00 1

    34232_at2, 3 U95-A 1 1.00 1.00 0.95 0.94 L04288 1.00 1.00 1.00 1

    920_at2, 3 U95-A 1 1.00 1.00 0.62 1.13 HG846-HT846 0.20 1.00 0.72 1

    34234_f_at2, 3 U95-A 1 1.00 1.00 -0.25 0.33 AI688640 0.60 1.00 0.82 1

    34233_i_at2, 3 U95-A 1 1.00 1.00 -0.42 0.20 AI688640 0.60 1.00 0.82 1

    88381_r_at2, 3 U95-D 1 1.00 1.00 0.50 0.72 AI341566 0.60 1.00 0.82 1

    215338_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI688640 0.60 1.00 0.82 1

    215339_at2, 3 U133-A 1 1.00 1.00 -- -- AI688640 0.60 1.00 0.82 1

    202380_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005385 0.60 1.00 0.82 1

    202379_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI361805 0.60 1.00 0.82 1

    215338_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1557736_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    215339_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202380_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202379_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1570342_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1557737_s_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    GeneDecks  NKTR for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAAAAGGACA

    SOURCE GeneReport for Unigene cluster: Hs.529509

    Expression variation in blood from EXPOLDB for NKTR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for NKTR gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    mouse
    (Mus musculus)
    Nktr1, 5 9 (71.00 cM)5
    natural killer tumor recognition sequence1, 5 81.81(n)1
    79.83(a)1
    180871  NM_010918.21  NP_035048.31 
     AI4654025  AI8470655  (see all 19)
    zebrafish
    (Danio rerio)
    nktr1   -- natural killer-tumor recognition sequence 53.67(n)
    49.18(a)
    323005  XM_001338036.2  XP_001338072.2 
    worm
    (Caenorhabditis elegans)
    cyp-83 X(8946628-8949076) Expression: intestine, pharynx, embryo,
    L1 larva, more
    56(a)   --
    African clawed frog
    (Xenopus laevis)
    BJ619911.12   --   -- 77.09(n)  BJ619911.1 
    tropical clawed frog
    (Silurana tropicalis)
    BX727354.12   --   -- 73.62(n)  BX727354.1 
    About this table        Species with no ortholog for NKTR

    ENSEMBL Gene Tree for NKTR
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for NKTR gene
    PPIL62  PPIL42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/261 NCBI SNPs in NKTR are shown (see all 261 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 87)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs3397291,2
    A,C,F,H,O42665289(-) AAGGAG/TATGAG 1 -- ng3111Minor allele frequency- T:0.34MN EA NA EU WA 998
    rs83511,2
    A,C,F,H42664781(-) ctcccC/Actttc 1 -- ut315Minor allele frequency- A:0.48MN EU EA WA 596
    rs339698241,2
    C,F42654781(+) GAACTT/GTGAAA 1 V/L mis13Minor allele frequency- G:0.25NA 256
    rs101549571,2
    F,H42665584(+) GCAGCG/ACACTA 1 -- ng314Minor allele frequency- A:0.01EU EA WA 412
    rs357703151,2
    C,F42655004(+) CAAGTC/TGTCCA 1 S/L mis15Minor allele frequency- T:0.07NA EU EA WA 496
    --
    rs31113121,2
    A,C42615426(-) TATCTA/GTAGAT 1 -- ng510--------
    rs98419261,2
    F,H42663737(+) TCCTCC/GAAAAA 1 -- ut314Minor allele frequency- G:0.01EU EA WA 412
    --
    rs31113131,2
    C42615398(-) cattaC/Tgtgaa 1 -- ng510--------
    --
    rs44477321,2
    H42654130(+) ATTTGC/TTACCC 1 L/L syn14Minor allele frequency- T:0.00EU EA WA 414
    rs355060051,2
    F42654852(+) AGTAAA/GTGGGA 1 K/K syn11Minor allele frequency- G:0.03NA 76
    About this table

    HapMap Linkage Disequilibrium images for NKTR (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 161565

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for NKTR gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4820 HGNC: 7833 AceView: NKTR Ensembl:ENSG00000114857 euGenes: HUgn4820
    ECgene: NKTR H-InvDB: NKTR
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for NKTR Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NKTR:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for NKTR Antibodies for NKTR
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NKTR Browse small molecules at Sigma-Aldrich
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