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Aliases for NKTR Gene

Aliases for NKTR Gene

  • Natural Killer Cell Triggering Receptor 2 3 5
  • Natural-Killer Cells Cyclophilin-Related Protein 2 3 4
  • NK-TR Protein 2 3 4
  • Natural Killer-Tumor Recognition Sequence 2 3
  • NK-Tumor Recognition Protein 2 3
  • Natural Killer Triggering Receptor 3
  • EC 5.2.1.8 61
  • P104 3

External Ids for NKTR Gene

Previous GeneCards Identifiers for NKTR Gene

  • GC03P041946
  • GC03P041822
  • GC03P042461
  • GC03P042602
  • GC03P042617

Summaries for NKTR Gene

Entrez Gene Summary for NKTR Gene

  • This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for NKTR Gene

NKTR (Natural Killer Cell Triggering Receptor) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIG.

UniProtKB/Swiss-Prot for NKTR Gene

  • Component of a putative tumor-recognition complex. Involved in the function of NK cells.

Gene Wiki entry for NKTR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKTR Gene

Genomics for NKTR Gene

Regulatory Elements for NKTR Gene

Enhancers for NKTR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F042650 1.2 FANTOM5 ENCODE 37.6 +53.2 53215 6.4 HDGF PKNOX1 ZFP64 SIN3A DMAP1 ZNF121 GLIS2 KLF7 FOS SP3 SEC22C NKTR SS18L2 HHATL FAM198A LOC101928323 ZBTB47
GH03F042610 0.6 Ensembl ENCODE 36.9 +11.5 11504 2.7 HDGF ATF1 ZFP64 ARID4B SIN3A DMAP1 GLIS2 ZNF143 KLF7 FOS NKTR SEC22C SS18L2 ZBTB47
GH03F042555 0.2 ENCODE 36.8 -44.2 -44239 1.4 FOSL1 ZNF146 TCF7 ZMYM3 ZBTB33 FOS NKTR VIPR1 CCDC13-AS1 CCDC13 VIPR1-AS1 SS18L2
GH03F042589 0.4 ENCODE 35.8 -9.6 -9649 2.5 HDGF PKNOX1 ATF1 SIN3A BRCA1 YY1 GTF3C2 GLIS2 FOS KLF13 SEC22C NKTR CCDC13-AS1 CCDC13 SNRK-AS1 SS18L2
GH03F042599 0.2 ENCODE 35 +0.5 521 3.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SEC22C NKTR ZBTB47
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NKTR on UCSC Golden Path with GeneCards custom track

Promoters for NKTR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001362103 386 2801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Transcription factor binding sites by QIAGEN in the NKTR gene promoter:

Genomic Location for NKTR Gene

Chromosome:
3
Start:
42,600,614 bp from pter
End:
42,648,741 bp from pter
Size:
48,128 bases
Orientation:
Plus strand

Genomic View for NKTR Gene

Genes around NKTR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKTR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKTR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKTR Gene

Proteins for NKTR Gene

  • Protein details for NKTR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30414-NKTR_HUMAN
    Recommended name:
    NK-tumor recognition protein
    Protein Accession:
    P30414

    Protein attributes for NKTR Gene

    Size:
    1462 amino acids
    Molecular mass:
    165677 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NKTR Gene

neXtProt entry for NKTR Gene

Selected DME Specific Peptides for NKTR Gene

P30414:
  • FMIQGGD
  • TNGSQFF
  • GGESIYG

Post-translational modifications for NKTR Gene

  • Ubiquitination at Lys 1258
  • Modification sites at PhosphoSitePlus

Domains & Families for NKTR Gene

Gene Families for NKTR Gene

Graphical View of Domain Structure for InterPro Entry

P30414

UniProtKB/Swiss-Prot:

NKTR_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
genes like me logo Genes that share domains with NKTR: view

Function for NKTR Gene

Molecular function for NKTR Gene

GENATLAS Biochemistry:
natural killer triggering receptor
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
Component of a putative tumor-recognition complex. Involved in the function of NK cells.

Enzyme Numbers (IUBMB) for NKTR Gene

Gene Ontology (GO) - Molecular Function for NKTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IBA --
GO:0016018 cyclosporin A binding TAS 8421688
GO:0016853 isomerase activity IEA --
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with NKTR: view
genes like me logo Genes that share phenotypes with NKTR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NKTR

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NKTR

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKTR Gene

Localization for NKTR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKTR Gene

Membrane; Peripheral membrane protein. Note=Attached to the membrane via its N-terminus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKTR Gene COMPARTMENTS Subcellular localization image for NKTR gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for NKTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NKTR: view

Pathways & Interactions for NKTR Gene

SuperPathways for NKTR Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with NKTR: view

No data available for Pathways by source and SIGNOR curated interactions for NKTR Gene

Transcripts for NKTR Gene

Unigene Clusters for NKTR Gene

Natural killer-tumor recognition sequence:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NKTR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKTR Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 17a · 17b ^ 18a · 18b · 18c
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NKTR Gene

GeneLoc Exon Structure for
NKTR
ECgene alternative splicing isoforms for
NKTR

Expression for NKTR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NKTR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NKTR Gene

This gene is overexpressed in Heart (45.8) and Cerebrospinal fluid (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NKTR Gene



Protein tissue co-expression partners for NKTR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NKTR Gene:

NKTR

SOURCE GeneReport for Unigene cluster for NKTR Gene:

Hs.529509
genes like me logo Genes that share expression patterns with NKTR: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NKTR Gene

Orthologs for NKTR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NKTR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKTR 34 35
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia NKTR 34 35
  • 90.26 (n)
dog
(Canis familiaris)
Mammalia NKTR 34 35
  • 90.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nktr 34 16 35
  • 81.89 (n)
rat
(Rattus norvegicus)
Mammalia Nktr 34
  • 79.27 (n)
oppossum
(Monodelphis domestica)
Mammalia NKTR 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKTR 34 35
  • 68.08 (n)
lizard
(Anolis carolinensis)
Reptilia NKTR 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nktr 35
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Moca-cyp 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyp-8 36
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3359 35
  • 51 (a)
OneToMany
Species where no ortholog for NKTR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKTR Gene

ENSEMBL:
Gene Tree for NKTR (if available)
TreeFam:
Gene Tree for NKTR (if available)

Paralogs for NKTR Gene

Paralogs for NKTR Gene

genes like me logo Genes that share paralogs with NKTR: view

Variants for NKTR Gene

Sequence variations from dbSNP and Humsavar for NKTR Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10154957 -- 42,649,088(+) GCAGC(A/G)CACTA intron-variant, downstream-variant-500B
rs10588617 -- 42,602,525(+) GACTC(-/AG)TGAGG intron-variant, upstream-variant-2KB
rs10588618 -- 42,602,644(+) TGATC(-/TTT)TTTTT intron-variant, upstream-variant-2KB
rs1062051 -- 42,630,994(+) TAATC(A/G)TTTCC intron-variant
rs10676488 -- 42,647,314(+) TGTGG(-/GT/GTGTGGT/T)TTTTT intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NKTR Gene

Variant ID Type Subtype PubMed ID
nsv3781 CNV insertion 18451855

Variation tolerance for NKTR Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKTR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKTR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKTR Gene

Disorders for NKTR Gene

Relevant External Links for NKTR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKTR

No disorders were found for NKTR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKTR Gene

Publications for NKTR Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Expression of the NK-TR gene is required for NK-like activity in human T cells. (PMID: 8144875) Chambers C.A. … Roder J. (J. Immunol. 1994) 2 3 64
  3. Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9. (PMID: 8314596) Young H.A. … Anderson S.K. (Genomics 1993) 2 3 64
  4. IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism. (PMID: 8413330) Rinfret A. … Anderson S.K. (Mol. Immunol. 1993) 3 22 64
  5. A cyclophilin-related protein involved in the function of natural killer cells. (PMID: 8421688) Anderson S.K. … Ortaldo J.R. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 64

Products for NKTR Gene

Sources for NKTR Gene

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