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NKTR Gene

protein-coding   GIFtS: 56
GCID: GC03P042643

Natural Killer Cell Triggering Receptor

(Previous name: natural killer-tumor recognition sequence)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Natural Killer Cell Triggering Receptor1 2     NK-Tumor Recognition Protein1 2
NK-TR Protein1 2 3     Natural Killer Triggering Receptor2
Natural-Killer Cells Cyclophilin-Related Protein1 2 3     p1042
Natural Killer-Tumor Recognition Sequence1 2     EC 5.2.1.88

External Ids:    HGNC: 78331   Entrez Gene: 48202   Ensembl: ENSG000001148577   OMIM: 1615655   UniProtKB: P304143   

Export aliases for NKTR gene to outside databases

Previous GC identifers: GC03P041946 GC03P041822 GC03P042461 GC03P042602 GC03P042617


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NKTR Gene:
This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like
PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its
expression is regulated by IL2 activation of the cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for NKTR Gene:
NKTR (natural killer cell triggering receptor) is a protein-coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPID.

UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414
Function: Component of a putative tumor-recognition complex. Involved in the function of NK cells

Gene Wiki entry for NKTR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKTR gene promoter:
         HEN1   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NKTR promoter sequence
   Search Chromatin IP Primers for NKTR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKTR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

NKTR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKTR gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P042643:  view genomic region     (about GC identifiers)

Start:
42,642,106 bp from pter      End:
42,690,233 bp from pter
Size:
48,128 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414 (See protein sequence)
Recommended Name: NK-tumor recognition protein  
Size: 1462 amino acids; 165677 Da
1 PDB 3D structure from and Proteopedia for NKTR:
2HE9 (3D)    

Explore the universe of human proteins at neXtProt for NKTR: NX_P30414

Explore proteomics data for NKTR at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1258
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for NKTR (P30414)
     FMIQGGD  GGESIYG  TNGSQFF 


    See NKTR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005376.2  
    ENSEMBL proteins: 
     ENSP00000232978   ENSP00000404802   ENSP00000390259   ENSP00000408660  

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    Novus Biologicals NKTR Protein
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    Cloud-Clone Corp. Proteins for NKTR

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P30414

    ProtoNet protein and cluster: P30414

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: NKTR_HUMAN, P30414
    Similarity: Contains 1 PPIase cyclophilin-type domain


    Find genes that share domains with NKTR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKTR_HUMAN, P30414
    Function: Component of a putative tumor-recognition complex. Involved in the function of NK cells
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Genatlas biochemistry entry for NKTR:
    natural killer triggering receptor

         Enzyme Number (IUBMB): EC 5.2.1.82

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0016018cyclosporin A binding TAS8421688
         
    Find genes that share ontologies with NKTR           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Nktr (no phenotypes)

    Find genes that share phenotypes with NKTR           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKTR
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKTR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NKTR

    miRNA
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    miRTarBase miRNAs that target NKTR:
    hsa-mir-335-5p (MIRT018671), hsa-mir-21-5p (MIRT030953)

    Block miRNA regulation of human, mouse, rat NKTR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NKTR (see all 58):
    hsa-miR-3607-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-29a hsa-miR-128 hsa-miR-624 hsa-miR-3653 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidNKTR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NKTR

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    GenScript: all cDNA clones in your preferred vector: NKTR (NM_005385)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKTR
    Addgene plasmids for NKTR 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKTR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NKTR_HUMAN, P30414: Membrane; Peripheral membrane protein. Note=Attached to the membrane via its N-terminus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--

    Find genes that share ontologies with NKTR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKTR
    Interactions:

        Search GeneGlobe Interaction Network for NKTR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NKTR (P304143 ENSP000002329784) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNPS1Q152873, ENSP000003158594I2D: score=3 STRING: ENSP00000315859
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    MAPK14Q165393, ENSP000002297944I2D: score=3 STRING: ENSP00000229794
    JUNP054123I2D: score=2 
    PACSIN1Q9BY113I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--

    Find genes that share ontologies with NKTR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NKTR



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NKTR gene (2 alternative transcripts): 
    NM_005385.3  NM_001012651.1  

    Unigene Cluster for NKTR:

    Natural killer-tumor recognition sequence
    Hs.529509  [show with all ESTs]
    Unigene Representative Sequence: NM_005385
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232978(uc003clo.3) ENST00000468735(uc003cll.1 uc003clm.1 uc003clr.1)
    ENST00000460910 ENST00000487466 ENST00000429888(uc003clp.3 uc011azp.2 uc003cls.3)
    ENST00000459950 ENST00000442970 ENST00000445842 ENST00000478488 ENST00000465584(uc003clq.1)
    ENST00000466553 ENST00000498730 ENST00000472127 ENST00000508351 ENST00000460807
    ENST00000464315 ENST00000472258 ENST00000490189
    miRNA
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    Block miRNA regulation of human, mouse, rat NKTR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NKTR (see all 58):
    hsa-miR-3607-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-29a hsa-miR-128 hsa-miR-624 hsa-miR-3653 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidNKTR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NKTR
    Predesigned siRNA for gene silencing in human, mouse, rat NKTR
    Clone
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    OriGene clones in human, mouse for NKTR (see all 7)
    OriGene ORF clones in mouse, rat for NKTR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NKTR (NM_005385)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKTR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKTR
    Addgene plasmids for NKTR 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NKTR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NKTR
      QuantiTect SYBR Green Assays in human, mouse, rat NKTR
      QuantiFast Probe-based Assays in human, mouse, rat NKTR

    Additional mRNA sequence: 

    AK093752.1 BC020672.1 BC144518.1 L04288.2 S65996.1 

    Selected DOTS entries (see all 29):

    DT.120783  DT.65284018  DT.95342764  DT.99978093  DT.75167322  DT.40117505  DT.448662  DT.120780 
    DT.91698317  DT.85104310  DT.40312655  DT.100642471  DT.120784  DT.92428429  DT.120908207  DT.87046221 
    DT.100686840  DT.120908157  DT.120908170  DT.120908206  DT.86854098  DT.86859540  DT.100774721  DT.120908107 

    Selected AceView cDNA sequences (see all 417):

    AI025728 BC020672 W04146 AA490321 AA400848 BM263875 AI688640 BP367676 
    AL120091 BM971532 CB122574 AA838015 CA397507 AI921190 BM728710 AW513424 
    BP362789 CR749415 AI638583 BQ028410 AI015621 AW085919 BU683985 AA910731 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NKTR (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
    SP1:                          -                 -           -                                                                                                   
    SP2:                                                                                                  -                 -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 17a · 17b ^ 18a · 18b · 18c
    SP1:                              
    SP2:                              
    SP3:  -                           
    SP4:  -                           
    SP5:                              


    ECgene alternative splicing isoforms for NKTR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NKTR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAGGACA
    NKTR Expression
    About this image


    NKTR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Condyle
     
     Thyroid (Endocrine System)
     
     Placenta (Extraembryonic Tissues)
     
     Spleen (Hematopoietic System)
    NKTR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NKTR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529509
        Custom PCR Arrays for NKTR
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKTR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NKTR gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nktr1 , 5 natural killer tumor recognition sequence1, 5 81.89(n)1
    79.96(a)1
      9 (72.57 cM)5
    180871  NM_010918.21  NP_035048.31 
     1217191695 
    chicken
    (Gallus gallus)
    Aves NKTR1 natural killer-tumor recognition sequence 68.08(n)
    64.79(a)
      420388  XM_004939074.1  XP_004939131.1 
    lizard
    (Anolis carolinensis)
    Reptilia NKTR6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    6(2642798-2675051)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ619911.12   -- 77.09(n)    BJ619911.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nktr6
    natural killer-tumor recognition sequence
    44(a)
    1 ↔ 1
    24(21252110-21267120) ENSDARG00000059097
    fruit fly
    (Drosophila melanogaster)
    Insecta Moca-cyp6
    Moca-cyp
    29(a)
    1 → many
    3R(24166060-24170891)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR66
    Peptidyl-prolyl cis-trans isomerase (cyclophilin),...
    35(a)
    1 → many
    XII(572096-573211) YLR216C


    ENSEMBL Gene Tree for NKTR (if available)
    TreeFam Gene Tree for NKTR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NKTR gene
    PPID2  PPIG2  PPIL62  
    Selected SIMAP similar genes for NKTR using alignment to 3 protein entries:     NKTR_HUMAN (see all proteins) (see all similar genes):
    DKFZp686G0426    DKFZp686J06106    DKFZp686N24126    PPIG    PPID    PPIL6
    PPIF    PPIE    PPIB    PPIH    RANBP2    PPIL1
    PPIA    PPIC    PPIAL4G    PPIAL4A    PPIAL4B    PPIAL4C

    Find genes that share paralogs with NKTR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NKTR (see all 902)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1489849801,2
    C--42644687(+) CCCTG-/TCTCTAC 1 -- int10--------
    rs594488731,2
    C--42644688(+) TGTCT-/CT/TC 
            
    ACAAA
    1 -- int10--------
    rs2010644721,2
    --42644701(+) AACAA-/TTTTTT 1 -- int10--------
    rs6389041,2
    C,F,A--42644781(+) caggaG/Ttttaa 1 -- int19Minor allele frequency- T:0.33NA WA CSA EA 370
    rs1477487621,2
    --42644832(+) GGTCAA/GCAGAG 1 -- int10--------
    rs6393451,2
    C,H--42644866(+) aaaaaC/Aaaaaa 1 -- int1 trp32Minor allele frequency- A:0.25NA CSA 4
    rs751431191,2
    C--42644949(+) ATCCTA/GGATTT 1 -- int10--------
    rs1879970751,2
    --42645071(+) AGCACC/TCTTGA 1 -- int10--------
    rs1925159081,2
    --42645080(+) GAGAAC/TGCCGA 1 -- int10--------
    rs6406891,2
    C,F,O,A,H--42645143(+) TGATAA/GTTGGA 1 -- int127Minor allele frequency- G:0.41NS EA NA WA CSA 2493

    HapMap Linkage Disequilibrium report for NKTR (42642106 - 42690233 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NKTR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3781CNV Insertion18451855
    nsv876730CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 161565    OMIM disorders: --


    Find genes that share disorders with NKTR           About GenesLikeMe


    Export disorders for NKTR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKTR gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with NKTR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. Expression of the NK-TR gene is required for NK-like activity in human T cells. (PubMed id 8144875)1, 3 Chambers C.A....Roder J. (J. Immunol. 1994)
    3. Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9. (PubMed id 8314596)1, 3 Young H.A....Anderson S.K. (Genomics 1993)
    4. A cyclophilin-related protein involved in the function of natural killer cells. (PubMed id 8421688)1, 2 Anderson S.K....Ortaldo J.R. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    5. IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism. (PubMed id 8413330)1, 9 Rinfret A. and Anderson S.K. (Mol. Immunol. 1993)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4820 HGNC: 7833 AceView: NKTR Ensembl:ENSG00000114857 euGenes: HUgn4820
    ECgene: NKTR H-InvDB: NKTR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NKTR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NKTR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NKTR gene:
    Search GeneIP for patents involving NKTR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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