Aliases for NKRF Gene
External Ids for NKRF Gene
Previous GeneCards Identifiers for NKRF Gene
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for NKRF Gene
NKRF (NFKB Repressing Factor) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding. An important paralog of this gene is CDKN2AIP.
UniProtKB/Swiss-Prot for NKRF Gene
Interacts with a specific negative regulatory element (NRE) 5-AATTCCTCTGA-3 to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.