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NKRF Gene

protein-coding   GIFtS: 53
GCID: GC0XM118722

NFKB Repressing Factor

(Previous name: NF-kappaB repressing factor)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NFKB Repressing Factor1 2     NF-KappaB Repressing Factor1
NRF2 3 5     NF-Kappa-B-Repressing Factor2
Transcription Factor NRF2 3     NFkB-Repressing Factor3
ITBA42 3     Protein ITBA43

External Ids:    HGNC: 193741   Entrez Gene: 559222   Ensembl: ENSG000001864167   OMIM: 3004405   UniProtKB: O152263   

Export aliases for NKRF gene to outside databases

Previous GC identifers: GC0XM118504 GC0XM118606 GC0XM108215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NKRF Gene:
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate
transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes
predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing
results in multiple transcript variants. (provided by RefSeq, Mar 2010)

GeneCards Summary for NKRF Gene:
NKRF (NFKB repressing factor) is a protein-coding gene. An important paralog of this gene is CDKN2AIPNL.

UniProtKB/Swiss-Prot: NKRF_HUMAN, O15226
Function: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional
repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta
promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced
iNOS promoter activity. Also involved in the regulation of IL-8 transcription

Gene Wiki entry for NKRF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKRF gene promoter:
         STAT5B   STAT1   GCNF   STAT1beta   NF-kappaB   STAT1alpha   GCNF-1   STAT2   NF-kappaB1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKRF promoter sequence
   Search Chromatin IP Primers for NKRF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKRF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

NKRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKRF gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM118722:  view genomic region     (about GC identifiers)

Start:
118,722,300 bp from pter      End:
118,739,858 bp from pter
Size:
17,559 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NKRF_HUMAN, O15226 (See protein sequence)
Recommended Name: NF-kappa-B-repressing factor  
Size: 690 amino acids; 77673 Da
Subunit: Interacts with NF-kappa-B
Sequence caution: Sequence=AL539002; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=CAB56459.1; Type=Frameshift; Positions=378, 405, 410, 441, 502, 516, 588, 599, 601, 681;
Secondary accessions: G3V1N1 Q4VC41 Q9UJ91
Alternative splicing: 2 isoforms:  O15226-1   O15226-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NKRF: NX_O15226

Explore proteomics data for NKRF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NKRF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166958.1  NP_001166959.1  NP_060014.2  

    ENSEMBL proteins: 
     ENSP00000360582   ENSP00000304803   ENSP00000442308  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPATCH: G patch domain containing

    3 InterPro protein domains:
     IPR001374 R3H_ss-bd
     IPR014720 dsRNA-bd_dom
     IPR000467 G_patch_dom

    Graphical View of Domain Structure for InterPro Entry O15226

    ProtoNet protein and cluster: O15226

    2 Blocks protein domains:
    IPB000467 D111/G-patch domain
    IPB001374 Single-stranded nucleic acid binding R3H


    UniProtKB/Swiss-Prot: NKRF_HUMAN, O15226
    Similarity: Contains 1 G-patch domain
    Similarity: Contains 1 R3H domain


    Find genes that share domains with NKRF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKRF_HUMAN, O15226
    Function: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional
    repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta
    promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced
    iNOS promoter activity. Also involved in the regulation of IL-8 transcription

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NKRF           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NKRF:
     Synthetic lethal with imatinib 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nkrf):
     no phenotypic analysis  normal 

    Find genes that share phenotypes with NKRF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nkrftm1.1Hjh for NKRF

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKRF
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    miRNA
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    miRTarBase miRNAs that target NKRF:
    hsa-mir-222-3p (MIRT046801), hsa-mir-326 (MIRT043642), hsa-mir-374b-5p (MIRT016042), hsa-mir-215-5p (MIRT024508), hsa-mir-192-5p (MIRT026214), hsa-mir-340-5p (MIRT019542), hsa-mir-301a-3p (MIRT004113)

    Block miRNA regulation of human, mouse, rat NKRF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NKRF (see all 32):
    hsa-miR-1287 hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-300 hsa-miR-29c hsa-miR-29a hsa-miR-624 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidNKRF 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NKRF_HUMAN, O15226: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10562553
    GO:0005730nucleolus IEA--

    Find genes that share ontologies with NKRF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKRF
    Interactions:

        GeneGlobe Interaction Network for NKRF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for NKRF (O152261, 2, 3 ENSP000003048034) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKRAO755692, 3, ENSP000003181764MINT-8267391 I2D: score=2 STRING: ENSP00000318176
    HMOX2P305192, 3MINT-8258357 I2D: score=2 
    DHX58Q96C101, 3, ENSP000002516424EBI-766011,EBI-744193 I2D: score=1 STRING: ENSP00000251642
    NFKB1P198383, ENSP000002265744I2D: score=3 STRING: ENSP00000226574
    NFKB2Q006533, ENSP000001894444I2D: score=3 STRING: ENSP00000189444
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045892negative regulation of transcription, DNA-templated IDA10562553

    Find genes that share ontologies with NKRF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NKRF



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NKRF gene (3 alternative transcripts): 
    NM_001173487.1  NM_001173488.1  NM_017544.3  

    Unigene Cluster for NKRF:

    NFKB repressing factor
    Hs.437084  [show with all ESTs]
    Unigene Representative Sequence: EF216689
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371527(uc004erq.3) ENST00000304449(uc004err.3) ENST00000487600
    ENST00000542113(uc022cdk.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NKRF (see all 32):
    hsa-miR-1287 hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-300 hsa-miR-29c hsa-miR-29a hsa-miR-624 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidNKRF 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat NKRF

    Additional mRNA sequence: 

    AJ011812.2 AY208891.1 BC040379.1 BC047878.2 BC068514.1 EF158333.1 EF165090.1 EF165091.1 
    EF165092.1 EF165093.1 EF165094.1 EF165095.1 EF216688.1 EF216689.1 Y07707.1 

    3 DOTS entries:

    DT.101980984  DT.454842  DT.407568 

    Selected AceView cDNA sequences (see all 99):

    BM450305 BE503422 BI836552 BM907133 AY208891 BQ683312 BG741433 AI089618 
    BX280197 AL539002 CR591991 BU629966 BU675893 BC047878 CB117211 AL544127 
    F35055 AI824139 CA489492 BF724986 BX343706 BQ014139 BC068514 CB132438 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NKRF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                    -                           
    SP2:              -     -                           
    SP3:                                                


    ECgene alternative splicing isoforms for NKRF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NKRF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTTCCAG
    NKRF Expression
    About this image

    NKRF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NKRF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437084

    UniProtKB/Swiss-Prot: NKRF_HUMAN, O15226
    Tissue specificity: Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood
    lymphocytes, lung and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NKRF gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkrf1 , 5 NF-kappaB repressing factor1, 5 91.16(n)1
    94.78(a)1
      X (21.30 cM)5
    772861  NM_029891.21  NP_084167.21 
     368875405 
    chicken
    (Gallus gallus)
    Aves NKRF1 NFKB repressing factor 69.42(n)
    69.57(a)
      422370  NM_001012887.1  NP_001012905.1 
    lizard
    (Anolis carolinensis)
    Reptilia NKRF6
    NFKB repressing factor
    61(a)
    1 ↔ 1
    GL344229.1(49595-53162)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.60732 Transcribed sequence with weak similarity to protein more 74.79(n)    142034390 
    zebrafish
    (Danio rerio)
    Actinopterygii nkrf1 NF-kappa B repressing factor 56.7(n)
    52.09(a)
      797627  NM_001004499.2  NP_001004499.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG313016
    --
    20(a)
    1 → many
    3R(11171953-11173734)


    ENSEMBL Gene Tree for NKRF (if available)
    TreeFam Gene Tree for NKRF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NKRF gene
    CDKN2AIPNL2  CDKN2AIP2  
    1 SIMAP similar gene for NKRF using alignment to 9 protein entries:     NKRF_HUMAN (see all proteins):
    NRF

    Find genes that share paralogs with NKRF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NKRF (see all 255)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808336281,2
    --118717966(+) TCGTTG/TGAACC 3 -- int10--------
    rs1852640391,2
    --118717971(+) TGAACA/CCAGGA 3 -- int10--------
    rs1135734051,2
    C,F--118718130(+) ATGTTT/GTCAAG 3 -- int11Minor allele frequency- G:0.00CSA 1
    rs1127725481,2
    C,F--118718153(+) CCTAAC/TTGTCC 3 -- int11Minor allele frequency- T:0.00CSA 1
    rs20183581,2
    C,F,O,A,H--118718190(+) AGTGAG/TCAATG 3 -- int133Minor allele frequency- N:0.00NA EA NS CSA 3198
    rs1432367441,2
    C--118718195(+) GCAATA/GGTAAA 3 -- int10--------
    rs1908190831,2
    C--118718261(+) TCACAA/TAAAAG 3 -- int10--------
    rs1834149041,2
    --118718686(+) CCACAG/TCTGTG 3 -- ut310--------
    rs413116541,2
    --118718842(+) TCTCAA/GGTAGT 3 -- ut310--------
    rs1914561181,2
    --118718875(+) AATTTA/GTTAAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for NKRF (118722300 - 118739858 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NKRF: --
    Locus Specific Mutation Databases (LSDB): NKRF

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NKRF
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300440    OMIM disorders: --


    Find genes that share disorders with NKRF           About GenesLikeMe

    Genetic Association Database (GAD): NKRF

    Export disorders for NKRF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKRF gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with NKRF)
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    1. Constitutive silencing of IFN-beta promoter is mediated by NRF (NF- kB-repressing factor), a nuclear inhibitor of NF-kB. (PubMed id 10562553)1, 2, 3, 9 Nourbakhsh M. and Hauser H. (EMBO J. 1999)
    2. Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: the role of NF-kappa B- repressing factor (NRF) in basal repression of the hiNOS gene. (PubMed id 12381793)1, 2, 9 Feng X....Geller D.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    5. Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25. (PubMed id 9224902)1, 2 Frattini A.... Vezzoni P. (Gene 1997)
    6. Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor. (PubMed id 19542452)1, 9 Ho S.C....Kuo H.P. (J. Immunol. 2009)
    7. Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF. (PubMed id 15226370)1, 9 Niedick I....KAPster M. (J. Cell. Sci. 2004)
    8. NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity- inducing factor. (PubMed id 16107696)1, 9 Dreikhausen U....Nourbakhsh M. (Mol. Cell. Biol. 2005)
    9. Cloning of the correct full length cDNA of NF-kappaB-repressing factor. (PubMed id 14744032)1, 9 Jianfeng D....Mao Y. (Mol. Cells 2003)
    10. NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14- nt RNA element. (PubMed id 17592041)1, 9 Reboll M.R.... Nourbakhsh M. (RNA 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55922 HGNC: 19374 AceView: NRF Ensembl:ENSG00000186416 euGenes: HUgn55922
    ECgene: NKRF H-InvDB: NKRF

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NKRF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NKRF gene:
    Search GeneIP for patents involving NKRF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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