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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKRF Gene

protein-coding   GIFtS: 53
GCID: GC0XM118722

NFKB repressing factor

(Previous name: NF-kappaB repressing factor )
 Explore 4 diseases affiliated with
NKRF via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NKRF    

Aliases
for NKRF gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NFKB Repressing Factor1 2     NF-KappaB Repressing Factor1
NRF1 2 3 5     NF-Kappa-B-Repressing Factor2
ITBA41 2 3     NFkB-Repressing Factor3
Transcription Factor NRF2 3     Protein ITBA43

External Ids:    HGNC: 193741   Entrez Gene: 559222   Ensembl: ENSG000001864167   OMIM: 3004405   UniProtKB: O152263   

Export aliases for NKRF gene to outside databases

Previous GC identifers: GC0XM118504 GC0XM118606 GC0XM108215


Summaries
for NKRF gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NKRF:
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate
transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to
the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple
transcript variants. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: NKRF_HUMAN, O15226
Function: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional
repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta
promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS
promoter activity. Also involved in the regulation of IL-8 transcription

Gene Wiki entry for NKRF


Genomic Views
for NKRF gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKRF gene promoter:
         STAT5B   STAT1   GCNF   STAT1beta   NF-kappaB   STAT1alpha   GCNF-1   STAT2   NF-kappaB1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKRF promoter sequence
   Search SABiosciences Chromatin IP Primers for NKRF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKRF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

NKRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKRF gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM118722:  view genomic region     (about GC identifiers)

Start:
 118,722,300 bp from pter      End:
 118,739,858 bp from pter
Size:
 17,559 bases      Orientation:
 minus strand

Proteins
for NKRF gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NKRF_HUMAN, O15226 (See protein sequence)
Recommended Name: NF-kappa-B-repressing factor  
Size: 690 amino acids; 77673 Da
Subunit: Interacts with NF-kappa-B
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=CAB56459.1; Type=Frameshift; Positions=378, 405, 410, 441, 502, 516, 588, 599, 601, 681;
Secondary accessions: Q4VC41 Q9UJ91

Explore the universe of human proteins at neXtProt for NKRF: NX_O15226

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15226

    • NKRF Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166958.1  NP_001166959.1  NP_060014.2  

    ENSEMBL proteins: 
     ENSP00000360582   ENSP00000304803   ENSP00000442308  

    Human Recombinant Protein Products: 
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    Novus Biologicals NKRF Proteins
    Novus Biologicals NKRF Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NKRF

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA10562553
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm ----


    NKRF for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NKRF gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NKRF for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001159 Ds-RNA-bd
     IPR000467 G_patch_dom
     IPR001374 R3H_ss-bd
     IPR014720 dsRNA-bd-like_dom

    Graphical View of Domain Structure for InterPro Entry O15226

    ProtoNet protein and cluster: O15226

    2 Blocks protein families:
    IPB000467 D111/G-patch domain
    IPB001374 Single-stranded nucleic acid binding R3H


    UniProtKB/Swiss-Prot: NKRF_HUMAN, O15226
    Similarity: Contains 1 G-patch domain
    Similarity: Contains 1 R3H domain


    Function
    for NKRF gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NKRF_HUMAN, O15226
    Function: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional
    repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta
    promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS
    promoter activity. Also involved in the regulation of IL-8 transcription

    miRNA
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    hsa-mir-301a (MIRT004113)

    OriGene 3'-UTR Clone: NKRF
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKRF
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate NKRF (see all 32):
    hsa-miR-1287 hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-300 hsa-miR-29c hsa-miR-29a hsa-miR-624 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NKRF 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKRF (see all 4)
    OriGene shRNA RFP: NKRF
    OriGene siRNA: NKRF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKRF

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NKRF

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKRF (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for NKRF

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003725double-stranded RNA binding IEA--
    GO:0005515protein binding IPI--


    NKRF for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NKRF:
     Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-out Nkrftm1.1Hjh for NKRF
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nkrf):
     no phenotypic analysis  normal 

    NKRF for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NKRF gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NKRF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/31 Interacting proteins for NKRF (O152261, 2, 3 ENSP000003048034) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKRAO755692, 3, ENSP000003181764MINT-8267391 I2D: score=2 STRING: ENSP00000318176
    HMOX2P305192, 3MINT-8258357 I2D: score=2 
    DHX58Q96C101, 3, ENSP000002516424EBI-766011,EBI-744193 I2D: score=1 STRING: ENSP00000251642
    NFKB1P198383, ENSP000002265744I2D: score=3 STRING: ENSP00000226574
    NFKB2Q006533, ENSP000001894444I2D: score=3 STRING: ENSP00000189444
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA10562553


    NKRF for ontologies           About GeneDecksing



    Drugs & Compounds
    for NKRF gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKRF
    Search CenterWatch for drugs/clinical trials and news about NKRF 

    Transcripts
    for NKRF gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NKRF gene (3 alternative transcripts): 
    NM_001173487.1  NM_001173488.1  NM_017544.3  

    Unigene Cluster for NKRF:

    NFKB repressing factor
    Hs.437084  [show with all ESTs]
    Unigene Representative Sequence: EF216689
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371527(uc004erq.3) ENST00000304449(uc004err.3) ENST00000487600
    ENST00000542113(uc022cdk.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NKRF
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKRF
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate NKRF (see all 32):
    hsa-miR-1287 hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-300 hsa-miR-29c hsa-miR-29a hsa-miR-624 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NKRF 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKRF (see all 4)
    OriGene shRNA RFP: NKRF
    OriGene siRNA: NKRF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKRF
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): NKRF (NM_017544)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKRF 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NKRF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKRF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKRF

    Additional cDNA sequence: 

    AJ011812.2 AY208891.1 BC040379.1 BC047878.2 BC068514.1 EF158333.1 EF165090.1 EF165091.1 
    EF165092.1 EF165093.1 EF165094.1 EF165095.1 EF216688.1 EF216689.1 Y07707.1 

    3 DOTS entries:

    DT.101980984  DT.454842  DT.407568 

    24/99 AceView cDNA sequences (see all 99):

    CB117211 BQ014139 CA489492 BG741433 BU629966 BX280197 CA454178 AI824139 
    AL544128 BU675893 BQ683312 BM907133 AY208891 BC040379 BQ003795 BC047878 
    CA314884 BE503422 AV729182 CB132438 AI419961 CR591991 BQ021613 BX343706 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NKRF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                    -                           
    SP2:              -     -                           
    SP3:                                                


    ECgene alternative splicing isoforms for NKRF

    Expression
    for NKRF gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKRF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATTTCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NKRF expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumEndocardial Tube CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NKRF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKRF

    SOURCE GeneReport for Unigene cluster: Hs.437084

    UniProtKB/Swiss-Prot: NKRF_HUMAN, O15226
    Tissue specificity: Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood
    lymphocytes, lung and kidney

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    In Situ
    Assay Products:     
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    Orthologs
    for NKRF gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NKRF gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nkrf1 , 5 NF-kappaB repressing factor1, 5 91.16(n)1
    94.78(a)1    		   X (21.30 cM)5
    772861  NM_029891.21  NP_084167.21 
     368875405 
    chicken
    (Gallus gallus)    		 Aves NKRF1 NFKB repressing factor 68.64(n)
    68.44(a)    		   422370  NM_001012887.1  NP_001012905.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NKRF6
    		 --
    		 62(a)
    		 1 ↔ 1
    		 GL344229.1(49595-53162)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.60732 Transcribed sequence with weak similarity to protein more 74.79(n)    142034390 
    zebrafish
    (Danio rerio)    		 Actinopterygii nkrf1 NF-kappa B repressing factor 56.01(n)
    51.14(a)    		   797627  NM_001004499.2  NP_001004499.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG313016
    		 --
    		 19(a)
    		 1 ↔ 1
    		 3R(11171953-11173734)


    ENSEMBL Gene Tree for NKRF (if available)
    TreeFam Gene Tree for NKRF (if available) 

    Paralogs
    for NKRF gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKRF gene
    CDKN2AIPNL2  CDKN2AIP2  
    1 SIMAP similar gene for NKRF using alignment to 10 protein entries:     NKRF_HUMAN (see all proteins):
    NRF

    NKRF for paralogs           About GeneDecksing



    Genomic Variants
    for NKRF gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/208 NCBI SNPs in NKRF are shown (see all 208)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1808336281,2
    		--118721800(+) TCGTTG/TGAACC 3 -- int10--------
    rs1852640391,2
    		--118721805(+) TGAACA/CCAGGA 3 -- int10--------
    rs1135734051,2
    		C,--118721964(+) ATGTTT/GTCAAG 3 -- int11Minor allele frequency- G:0.00CSA 1
    rs1127725481,2
    		C,--118721987(+) CCTAAC/TTGTCC 3 -- int11Minor allele frequency- T:0.00CSA 1
    rs20183581,2
    		C,F,O,A,H,--118722024(+) AGTGAG/TCAATG 3 -- int133Minor allele frequency- N:0.00NA EA NS CSA 3198
    rs1432367441,2
    		--118722029(+) GCAATA/GGTAAA 3 -- int10--------
    rs1908190831,2
    		--118722095(+) TCACAA/TAAAAG 3 -- int10--------
    rs1834149041,2
    		--118722520(+) CCACAG/TCTGTG 3 -- ut310--------
    rs413116541,2
    		--118722676(+) TCTCAA/GGTAGT 3 -- ut310--------
    rs1914561181,2
    		--118722709(+) AATTTA/GTTAAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for NKRF (118722300 - 118739858 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NKRF: --
    Locus Specific Mutation Databases (LSDB): NKRF

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKRF
    DNA2.0 Custom Variant and Variant Library Synthesis for NKRF

    Disorders / Diseases
    for NKRF gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NKRF for disorders           About GeneDecksing

    OMIM gene information: 300440    OMIM disorders: --

    4 diseases for NKRF:    About MalaCards
    mastitis    pharyngitis    colorectal cancer    immunodeficiency


    Export disorders for NKRF gene to outside databases

    Publications
    for NKRF gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKRF gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with NKRF)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Constitutive silencing of IFN-beta promoter is mediated by NRF (NF- kB-repressing factor), a nuclear inhibitor of NF-kB. (PubMed id 10562553)1, 2, 3, 9 Nourbakhsh M. and Hauser H. (1999)
    2. Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: the role of NF-kappa B- repressing factor (NRF) in basal repression of the hiNOS gene. (PubMed id 12381793)1, 2, 9 Feng X....Geller D.A. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    5. Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25. (PubMed id 9224902)1, 2 Frattini A.... Vezzoni P. (1997)
    6. Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing fa ctor. (PubMed id 19542452)1, 9 Ho S.C....Kuo H.P. (2009)
    7. Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF. (PubMed id 15226370)1, 9 Niedick I....Koster M. (2004)
    8. NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity- inducing factor. (PubMed id 16107696)1, 9 Dreikhausen U....Nourbakhsh M. (2005)
    9. Cloning of the correct full length cDNA of NF-kappaB-repressing factor. (PubMed id 14744032)1, 9 Jianfeng D....Mao Y. (2003)
    10. NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14- nt RNA element. (PubMed id 17592041)1, 9 Reboll M.R.... Nourbakhsh M. (2007)

    External Searches for NKRF gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NKRF gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55922 HGNC: 19374 AceView: NRF Ensembl:ENSG00000186416 euGenes: HUgn55922
    ECgene: NKRF H-InvDB: NKRF

    Other Databases showing NKRF gene

    (According to HUGE)
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    Specialized Databases showing NKRF gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKRF Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NKRF gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for NKRF gene:
    Search GeneIP for patents involving NKRF

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