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Aliases for NKRF Gene

Aliases for NKRF Gene

  • NFKB Repressing Factor 2 3
  • NRF 3 4 6
  • Transcription Factor NRF 3 4
  • ITBA4 3 4
  • NF-Kappa-B-Repressing Factor 3
  • NF-KappaB Repressing Factor 2
  • NFkB-Repressing Factor 4
  • Protein ITBA4 4

External Ids for NKRF Gene

Summaries for NKRF Gene

Entrez Gene Summary for NKRF Gene

  • This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for NKRF Gene

NKRF (NFKB Repressing Factor) is a Protein Coding gene. An important paralog of this gene is CDKN2AIP.

UniProtKB/Swiss-Prot for NKRF Gene

  • Interacts with a specific negative regulatory element (NRE) 5-AATTCCTCTGA-3 to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.

Gene Wiki entry for NKRF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKRF Gene

Genomics for NKRF Gene

Genomic Location for NKRF Gene

Start:
119,588,337 bp from pter
End:
119,605,895 bp from pter
Size:
17,559 bases
Orientation:
Minus strand

Genomic View for NKRF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKRF Gene

Regulatory Elements for NKRF Gene

Proteins for NKRF Gene

  • Protein details for NKRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15226-NKRF_HUMAN
    Recommended name:
    NF-kappa-B-repressing factor
    Protein Accession:
    O15226
    Secondary Accessions:
    • G3V1N1
    • Q4VC41
    • Q9UJ91

    Protein attributes for NKRF Gene

    Size:
    690 amino acids
    Molecular mass:
    77673 Da
    Quaternary structure:
    • Interacts with NF-kappa-B
    SequenceCaution:
    • Sequence=AL539002; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAB56459.1; Type=Frameshift; Positions=378, 405, 410, 441, 502, 516, 588, 599, 601, 681; Evidence={ECO:0000305};

    Alternative splice isoforms for NKRF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKRF Gene

Proteomics data for NKRF Gene at MOPED

Post-translational modifications for NKRF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKRF Gene

No data available for DME Specific Peptides for NKRF Gene

Domains for NKRF Gene

Gene Families for NKRF Gene

HGNC:
  • GPATCH :G patch domain containing

Protein Domains for NKRF Gene

UniProtKB/Swiss-Prot:

NKRF_HUMAN
Domain:
  • Contains 1 G-patch domain.:
    • O15226
  • Contains 1 R3H domain.:
    • O15226
genes like me logo Genes that share domains with NKRF: view

Function for NKRF Gene

Molecular function for NKRF Gene

UniProtKB/Swiss-Prot Function: Interacts with a specific negative regulatory element (NRE) 5-AATTCCTCTGA-3 to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.

Gene Ontology (GO) - Molecular Function for NKRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21903422
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NKRF: view

Phenotypes for NKRF Gene

MGI mutant phenotypes for NKRF:
inferred from 2 alleles
GenomeRNAi human phenotypes for NKRF:
genes like me logo Genes that share phenotypes with NKRF: view

Animal Models for NKRF Gene

MGI Knock Outs for NKRF:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NKRF Gene

Localization for NKRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKRF Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKRF Gene COMPARTMENTS Subcellular localization image for NKRF gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NKRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with NKRF: view

Pathways for NKRF Gene

SuperPathways for NKRF Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 10562553
genes like me logo Genes that share ontologies with NKRF: view

No data available for Pathways by source for NKRF Gene

Transcripts for NKRF Gene

Unigene Clusters for NKRF Gene

NFKB repressing factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKRF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for NKRF Gene

GeneLoc Exon Structure for
NKRF
ECgene alternative splicing isoforms for
NKRF

Expression for NKRF Gene

mRNA expression in normal human tissues for NKRF Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NKRF Gene

SOURCE GeneReport for Unigene cluster for NKRF Gene Hs.437084

mRNA Expression by UniProt/SwissProt for NKRF Gene

O15226-NKRF_HUMAN
Tissue specificity: Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney
genes like me logo Genes that share expressions with NKRF: view

Orthologs for NKRF Gene

This gene was present in the common ancestor of animals.

Orthologs for NKRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKRF 36
  • 99.86 (n)
  • 100 (a)
NKRF 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKRF 36
  • 93.86 (n)
  • 96.52 (a)
NKRF 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKRF 36
  • 94.16 (n)
  • 97.84 (a)
NKRF 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkrf 36
  • 91.16 (n)
  • 94.78 (a)
Nkrf 16
Nkrf 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKRF 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 69 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves NKRF 36
  • 69.42 (n)
  • 69.57 (a)
NKRF 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKRF 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkrf 36
  • 61.19 (n)
  • 56.07 (a)
Str.6073 36
zebrafish
(Danio rerio)
Actinopterygii nkrf 36
  • 56.7 (n)
  • 52.09 (a)
nkrf 37
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31301 37
  • 20 (a)
OneToMany
Species with no ortholog for NKRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKRF Gene

ENSEMBL:
Gene Tree for NKRF (if available)
TreeFam:
Gene Tree for NKRF (if available)

Paralogs for NKRF Gene

Paralogs for NKRF Gene

Selected SIMAP similar genes for NKRF Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with NKRF: view

Variants for NKRF Gene

Sequence variations from dbSNP and Humsavar for NKRF Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs802801 -- 119,601,030(+) CAAGT(A/G)TAAAA intron-variant
rs2018358 -- 119,588,061(+) AGTGA(G/T)CAATG downstream-variant-500B
rs2233497 -- 119,592,649(-) AGGGC(C/T)GATTC intron-variant, utr-variant-5-prime
rs2233498 -- 119,590,450(-) GCTTC(C/T)GGGCA reference, synonymous-codon
rs2527609 -- 119,606,548(+) GCGGA(A/G)GGCGG upstream-variant-2KB

Relevant External Links for NKRF Gene

HapMap Linkage Disequilibrium report
NKRF
Locus Specific Mutation Databases (LSDB)
NKRF

No data available for Structural Variations from Database of Genomic Variants (DGV) for NKRF Gene

Disorders for NKRF Gene

Relevant External Links for NKRF

Genetic Association Database (GAD)
NKRF
genes like me logo Genes that share disorders with NKRF: view

No data available for UniProtKB/Swiss-Prot for NKRF Gene

Publications for NKRF Gene

  1. Constitutive silencing of IFN-beta promoter is mediated by NRF (NF- kB-repressing factor), a nuclear inhibitor of NF-kB. (PMID: 10562553) Nourbakhsh M. … Hauser H. (EMBO J. 1999) 2 3 4 23
  2. Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: the role of NF-kappa B- repressing factor (NRF) in basal repression of the hiNOS gene. (PMID: 12381793) Feng X. … Geller D.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  3. Cloning of the correct full length cDNA of NF-kappaB-repressing factor. (PMID: 14744032) Jianfeng D. … Mao Y. (Mol. Cells 2003) 3 23
  4. Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF. (PMID: 15226370) Niedick I. … KAPster M. (J. Cell. Sci. 2004) 3 23
  5. NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity- inducing factor. (PMID: 16107696) Dreikhausen U. … Nourbakhsh M. (Mol. Cell. Biol. 2005) 3 23

Products for NKRF Gene

Sources for NKRF Gene

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