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Aliases for NKPD1 Gene

Aliases for NKPD1 Gene

  • NTPase, KAP Family P-Loop Domain Containing 1 2 3

External Ids for NKPD1 Gene

Previous GeneCards Identifiers for NKPD1 Gene

  • GC19M050347
  • GC19M050348
  • GC19M045655
  • GC19M042083

Summaries for NKPD1 Gene

GeneCards Summary for NKPD1 Gene

NKPD1 (NTPase, KAP Family P-Loop Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKPD1 Gene

Genomics for NKPD1 Gene

Regulatory Elements for NKPD1 Gene

Genomic Location for NKPD1 Gene

Start:
45,149,750 bp from pter
End:
45,160,150 bp from pter
Size:
10,401 bases
Orientation:
Minus strand

Genomic View for NKPD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKPD1 Gene

Proteins for NKPD1 Gene

  • Protein details for NKPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RQ9-NKPD1_HUMAN
    Recommended name:
    NTPase KAP family P-loop domain-containing protein 1
    Protein Accession:
    Q17RQ9
    Secondary Accessions:
    • B7ZLG6
    • D6RH15
    • Q8N2A2

    Protein attributes for NKPD1 Gene

    Size:
    610 amino acids
    Molecular mass:
    67780 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03547.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

neXtProt entry for NKPD1 Gene

Proteomics data for NKPD1 Gene at MOPED

Post-translational modifications for NKPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKPD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKPD1 Gene

Domains for NKPD1 Gene

Protein Domains for NKPD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17RQ9

UniProtKB/Swiss-Prot:

NKPD1_HUMAN :
  • Q17RQ9
Domain:
  • Contains 1 KAP NTPase domain.
genes like me logo Genes that share domains with NKPD1: view

No data available for Gene Families for NKPD1 Gene

Function for NKPD1 Gene

Phenotypes for NKPD1 Gene

genes like me logo Genes that share phenotypes with NKPD1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NKPD1 Gene

Localization for NKPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKPD1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKPD1 Gene COMPARTMENTS Subcellular localization image for NKPD1 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NKPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NKPD1: view

Pathways for NKPD1 Gene

SuperPathways for NKPD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKPD1 Gene

None

No data available for Pathways by source for NKPD1 Gene

Transcripts for NKPD1 Gene

mRNA/cDNA for NKPD1 Gene

(9) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKPD1 Gene

NTPase, KAP family P-loop domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKPD1 Gene

No ASD Table

Relevant External Links for NKPD1 Gene

GeneLoc Exon Structure for
NKPD1
ECgene alternative splicing isoforms for
NKPD1

Expression for NKPD1 Gene

mRNA expression in normal human tissues for NKPD1 Gene

mRNA differential expression in normal tissues according to GTEx for NKPD1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (18.6) and Skin - Sun Exposed (Lower leg) (16.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NKPD1 Gene

SOURCE GeneReport for Unigene cluster for NKPD1 Gene Hs.299256

genes like me logo Genes that share expressions with NKPD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NKPD1 Gene

Orthologs for NKPD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NKPD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKPD1 35
  • 99.52 (n)
  • 99.52 (a)
NKPD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKPD1 35
  • 86.19 (n)
  • 81.5 (a)
NKPD1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKPD1 35
  • 87.1 (n)
  • 82.43 (a)
NKPD1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkpd1 35
  • 83.15 (n)
  • 81.6 (a)
Nkpd1 16
Nkpd1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKPD1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkpd1 35
  • 83.15 (n)
  • 81.47 (a)
lizard
(Anolis carolinensis)
Reptilia NKPD1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489552 35
  • 52.18 (n)
  • 48.45 (a)
zebrafish
(Danio rerio)
Actinopterygii BX119916.1 36
  • 27 (a)
OneToOne
LOC561946 35
  • 45.22 (n)
  • 35.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
Species with no ortholog for NKPD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKPD1 Gene

ENSEMBL:
Gene Tree for NKPD1 (if available)
TreeFam:
Gene Tree for NKPD1 (if available)

Paralogs for NKPD1 Gene

No data available for Paralogs for NKPD1 Gene

Variants for NKPD1 Gene

Sequence variations from dbSNP and Humsavar for NKPD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs880750 -- 45,152,503(-) GGACT(C/T)TGGGG missense, reference
rs880751 -- 45,152,400(-) CAGCA(A/G)Accgg synonymous-codon, reference
rs1005452 -- 45,149,414(+) gcaat(C/G)cacca downstream-variant-500B
rs1054470 -- 45,149,976(-) AAAAA(A/G)GGAGC utr-variant-3-prime
rs1985440 -- 45,157,714(-) GTATg(G/T)ctggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKPD1 Gene

Variant ID Type Subtype PubMed ID
nsv912142 CNV Loss 21882294
nsv833842 CNV Loss 17160897
nsv833843 CNV Loss 17160897
nsv912143 CNV Loss 21882294
nsv912144 CNV Loss 21882294
nsv522341 CNV Loss 19592680
nsv520051 CNV Loss 19592680

Relevant External Links for NKPD1 Gene

HapMap Linkage Disequilibrium report
NKPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKPD1 Gene

Disorders for NKPD1 Gene

No disorders were found for NKPD1 Gene.

No data available for UniProtKB/Swiss-Prot for NKPD1 Gene

Publications for NKPD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines. (PMID: 15935074) Pinto C.S. … Seifert R. (J. Neurochem. 2005) 3
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NKPD1 Gene

Sources for NKPD1 Gene

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