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Aliases for NKPD1 Gene

Aliases for NKPD1 Gene

  • NTPase KAP Family P-Loop Domain Containing 1 2 3 5
  • NTPase, KAP Family P-Loop Domain Containing 1 2

External Ids for NKPD1 Gene

Previous GeneCards Identifiers for NKPD1 Gene

  • GC19M050347
  • GC19M050348
  • GC19M045655
  • GC19M042083

Summaries for NKPD1 Gene

GeneCards Summary for NKPD1 Gene

NKPD1 (NTPase KAP Family P-Loop Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKPD1 Gene

Genomics for NKPD1 Gene

Regulatory Elements for NKPD1 Gene

Enhancers for NKPD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G045096 2 FANTOM5 Ensembl ENCODE dbSUPER 7.2 +61.4 61444 9.7 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF143 FOS ZNF548 ZNF263 SP3 GEMIN7 ZNF180 ZNF234 FOSB ZNF296 PPP1R37 RELB CCDC61 CLASRP ZNF225
GH19G045163 1.3 Ensembl ENCODE 8.7 -1.8 -1764 1.5 HDGF PKNOX1 ARNT AGO1 WRNIP1 ARID4B YBX1 ZNF766 ZNF143 ZNF207 ZNF180 IRF2BP1 ENSG00000267114 RELB PPP1R37 NKPD1 TRAPPC6A
GH19G045089 1.4 ENCODE dbSUPER 7.2 +70.4 70449 5.3 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 ZNF180 ZNF225 ZNF224 ZNF234 ZNF285 GEMIN7 LOC100379224 CCDC61 ENSG00000267114 IRF2BP1
GH19G045115 1.4 Ensembl ENCODE dbSUPER 7.1 +45.5 45451 4.5 HDGF PKNOX1 SIN3A YBX1 RAD21 ZNF366 EGR1 ZNF143 RELB IKZF2 GEMIN7 PPP1R37 NKPD1 PIR57496 GC19M045094
GH19G045151 1.3 Ensembl ENCODE 7.6 +9.5 9500 3.7 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B DMAP1 SP5 JUNB MXD4 ZNF285 PPP1R37 NOVA2 GEMIN7 NKPD1 LOC105372420 GC19M045151
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NKPD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NKPD1 Gene

Chromosome:
19
Start:
45,149,111 bp from pter
End:
45,162,841 bp from pter
Size:
13,731 bases
Orientation:
Minus strand

Genomic View for NKPD1 Gene

Genes around NKPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKPD1 Gene

Proteins for NKPD1 Gene

  • Protein details for NKPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RQ9-NKPD1_HUMAN
    Recommended name:
    NTPase KAP family P-loop domain-containing protein 1
    Protein Accession:
    Q17RQ9
    Secondary Accessions:
    • B7ZLG6
    • D6RH15
    • Q8N2A2

    Protein attributes for NKPD1 Gene

    Size:
    610 amino acids
    Molecular mass:
    67780 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03547.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

neXtProt entry for NKPD1 Gene

Post-translational modifications for NKPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKPD1 Gene

No data available for DME Specific Peptides for NKPD1 Gene

Domains & Families for NKPD1 Gene

Protein Domains for NKPD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NKPD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NKPD1 Gene

Function for NKPD1 Gene

Phenotypes for NKPD1 Gene

genes like me logo Genes that share phenotypes with NKPD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKPD1 Gene

Localization for NKPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKPD1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKPD1 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NKPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NKPD1: view

Pathways & Interactions for NKPD1 Gene

SuperPathways for NKPD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKPD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NKPD1 Gene

Drugs & Compounds for NKPD1 Gene

No Compound Related Data Available

Transcripts for NKPD1 Gene

mRNA/cDNA for NKPD1 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKPD1 Gene

NTPase, KAP family P-loop domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKPD1 Gene

No ASD Table

Relevant External Links for NKPD1 Gene

GeneLoc Exon Structure for
NKPD1
ECgene alternative splicing isoforms for
NKPD1

Expression for NKPD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKPD1 Gene

mRNA differential expression in normal tissues according to GTEx for NKPD1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x18.6) and Skin - Sun Exposed (Lower leg) (x16.1).

Protein differential expression in normal tissues from HIPED for NKPD1 Gene

This gene is overexpressed in Serum (56.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NKPD1 Gene



Protein tissue co-expression partners for NKPD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NKPD1 Gene:

NKPD1

SOURCE GeneReport for Unigene cluster for NKPD1 Gene:

Hs.299256

Evidence on tissue expression from TISSUES for NKPD1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NKPD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKPD1 Gene

Orthologs for NKPD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NKPD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKPD1 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia NKPD1 34 35
  • 87.1 (n)
cow
(Bos Taurus)
Mammalia NKPD1 34 35
  • 86.19 (n)
mouse
(Mus musculus)
Mammalia Nkpd1 34 16 35
  • 83.15 (n)
rat
(Rattus norvegicus)
Mammalia Nkpd1 34
  • 83.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NKPD1 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKPD1 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489552 34
  • 52.18 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC561946 34
  • 45.22 (n)
BX119916.1 35
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
-- 35
  • 21 (a)
OneToMany
Species where no ortholog for NKPD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKPD1 Gene

ENSEMBL:
Gene Tree for NKPD1 (if available)
TreeFam:
Gene Tree for NKPD1 (if available)

Paralogs for NKPD1 Gene

No data available for Paralogs for NKPD1 Gene

Variants for NKPD1 Gene

Sequence variations from dbSNP and Humsavar for NKPD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000155211 -- 45,155,371(+) AGTTG(A/G)CATCT intron-variant
rs1000200920 -- 45,152,931(+) CTCTC(C/T)AGGCA upstream-variant-2KB, reference, synonymous-codon
rs1000505161 -- 45,157,519(+) GGATC(C/G)TCCTT intron-variant, downstream-variant-500B
rs1000537655 -- 45,157,793(+) CATCT(C/T)GGCTC intron-variant, downstream-variant-500B
rs1000690759 -- 45,161,107(+) AGGAC(A/T)GGGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NKPD1 Gene

Variant ID Type Subtype PubMed ID
nsv520051 CNV loss 19592680
nsv522341 CNV loss 19592680
nsv833842 CNV loss 17160897
nsv833843 CNV loss 17160897
nsv953587 CNV deletion 24416366

Variation tolerance for NKPD1 Gene

Gene Damage Index Score: 6.12; 75.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKPD1 Gene

Human Gene Mutation Database (HGMD)
NKPD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKPD1 Gene

Disorders for NKPD1 Gene

Relevant External Links for NKPD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKPD1

No disorders were found for NKPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKPD1 Gene

Publications for NKPD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines. (PMID: 15935074) Pinto C.S. … Seifert R. (J. Neurochem. 2005) 3 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for NKPD1 Gene

Sources for NKPD1 Gene

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