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Aliases for NKPD1 Gene

Aliases for NKPD1 Gene

  • NTPase, KAP Family P-Loop Domain Containing 1 2 3 5

External Ids for NKPD1 Gene

Previous GeneCards Identifiers for NKPD1 Gene

  • GC19M050347
  • GC19M050348
  • GC19M045655
  • GC19M042083

Summaries for NKPD1 Gene

GeneCards Summary for NKPD1 Gene

NKPD1 (NTPase, KAP Family P-Loop Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKPD1 Gene

Genomics for NKPD1 Gene

Regulatory Elements for NKPD1 Gene

Genomic Location for NKPD1 Gene

45,149,111 bp from pter
45,162,841 bp from pter
13,731 bases
Minus strand

Genomic View for NKPD1 Gene

Genes around NKPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKPD1 Gene

Proteins for NKPD1 Gene

  • Protein details for NKPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NTPase KAP family P-loop domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B7ZLG6
    • D6RH15
    • Q8N2A2

    Protein attributes for NKPD1 Gene

    610 amino acids
    Molecular mass:
    67780 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03547.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

neXtProt entry for NKPD1 Gene

Proteomics data for NKPD1 Gene at MOPED

Post-translational modifications for NKPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKPD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKPD1 Gene

Domains & Families for NKPD1 Gene

Protein Domains for NKPD1 Gene


Suggested Antigen Peptide Sequences for NKPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KAP NTPase domain.
  • Contains 1 KAP NTPase domain.
genes like me logo Genes that share domains with NKPD1: view

No data available for Gene Families for NKPD1 Gene

Function for NKPD1 Gene

Phenotypes for NKPD1 Gene

genes like me logo Genes that share phenotypes with NKPD1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKPD1 Gene

Localization for NKPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKPD1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NKPD1 Gene COMPARTMENTS Subcellular localization image for NKPD1 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for NKPD1 Gene

Pathways & Interactions for NKPD1 Gene

SuperPathways for NKPD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKPD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for NKPD1 Gene

Drugs & Compounds for NKPD1 Gene

No Compound Related Data Available

Transcripts for NKPD1 Gene

mRNA/cDNA for NKPD1 Gene

(9) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKPD1 Gene

NTPase, KAP family P-loop domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKPD1 Gene

No ASD Table

Relevant External Links for NKPD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKPD1 Gene

mRNA expression in normal human tissues for NKPD1 Gene

mRNA differential expression in normal tissues according to GTEx for NKPD1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x18.6) and Skin - Sun Exposed (Lower leg) (x16.1).

Protein differential expression in normal tissues from HIPED for NKPD1 Gene

This gene is overexpressed in Serum (56.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NKPD1 Gene

SOURCE GeneReport for Unigene cluster for NKPD1 Gene Hs.299256

genes like me logo Genes that share expression patterns with NKPD1: view

Protein tissue co-expression partners for NKPD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NKPD1 Gene

Orthologs for NKPD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NKPD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NKPD1 35
  • 86.19 (n)
  • 81.5 (a)
NKPD1 36
  • 80 (a)
(Canis familiaris)
Mammalia NKPD1 35
  • 87.1 (n)
  • 82.43 (a)
NKPD1 36
  • 84 (a)
(Mus musculus)
Mammalia Nkpd1 35
  • 83.15 (n)
  • 81.6 (a)
Nkpd1 16
Nkpd1 36
  • 79 (a)
(Pan troglodytes)
Mammalia NKPD1 35
  • 99.52 (n)
  • 99.52 (a)
NKPD1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nkpd1 35
  • 83.15 (n)
  • 81.47 (a)
(Ornithorhynchus anatinus)
Mammalia NKPD1 36
  • 72 (a)
(Anolis carolinensis)
Reptilia NKPD1 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489552 35
  • 52.18 (n)
  • 48.45 (a)
(Danio rerio)
Actinopterygii LOC561946 35
  • 45.22 (n)
  • 35.66 (a)
BX119916.1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
-- 36
  • 31 (a)
-- 36
  • 21 (a)
Species with no ortholog for NKPD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKPD1 Gene

Gene Tree for NKPD1 (if available)
Gene Tree for NKPD1 (if available)

Paralogs for NKPD1 Gene

No data available for Paralogs for NKPD1 Gene

Variants for NKPD1 Gene

Sequence variations from dbSNP and Humsavar for NKPD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_033146 -
rs1054470 -- 45,149,976(-) AAAAA(A/G)GGAGC utr-variant-3-prime
rs1005451 -- 45,148,821(+) CTTTC(C/T)TACTG downstream-variant-500B
rs1005452 -- 45,149,414(+) gcaat(C/G)cacca downstream-variant-500B, utr-variant-3-prime
rs8109620 -- 45,159,201(+) CCAGA(A/G)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKPD1 Gene

Variant ID Type Subtype PubMed ID
nsv912142 CNV Loss 21882294
nsv833842 CNV Loss 17160897
nsv833843 CNV Loss 17160897
nsv912143 CNV Loss 21882294
nsv912144 CNV Loss 21882294
nsv522341 CNV Loss 19592680
nsv520051 CNV Loss 19592680

Variation tolerance for NKPD1 Gene

Gene Damage Index Score: 6.12; 75.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKPD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKPD1 Gene

Disorders for NKPD1 Gene

Relevant External Links for NKPD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NKPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKPD1 Gene

Publications for NKPD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines. (PMID: 15935074) Pinto C.S. … Seifert R. (J. Neurochem. 2005) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NKPD1 Gene

Sources for NKPD1 Gene

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