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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKIRAS2 Gene

protein-coding   GIFtS: 55
GCID: GC17P040170

NFKB inhibitor interacting Ras-like 2

(Previous name: NFKB inhibitor interacting Ras-like protein 2 )
 Explore 3 diseases affiliated with
NKIRAS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NKIRAS2    

Aliases
for NKIRAS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NFKB Inhibitor Interacting Ras-Like 21 2     I-Kappa-B-Interacting Ras-Like Protein 22 3
KBRAS21 2 3     DKFZP434N15261
KappaB-Ras23     NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 22
NFKB Inhibitor Interacting Ras-Like Protein 21 2     KappaB-Ras23
Kappa B-Ras Protein 22 3     

External Ids:    HGNC: 178981   Entrez Gene: 285112   Ensembl: ENSG000001682567   OMIM: 6044975   UniProtKB: Q9NYR93   

Export aliases for NKIRAS2 gene to outside databases

Previous GC identifers: GC17P040546 GC17P037422 GC17P035934


Summaries
for NKIRAS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9
Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It
is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity)

Gene Wiki entry for NKIRAS2


Genomic Views
for NKIRAS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKIRAS2 gene promoter:
         p53   NRSF form 1   CUTL1   NRSF form 2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKIRAS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKIRAS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKIRAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.31

NKIRAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKIRAS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040170:  view genomic region     (about GC identifiers)

Start:
 40,163,400 bp from pter      End:
 40,177,659 bp from pter
Size:
 14,260 bases      Orientation:
 plus strand

Proteins
for NKIRAS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor-interacting Ras-like protein 2  
Size: 191 amino acids; 21508 Da
Subunit: Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only
interacts with NFKBIB in vivo
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAB55006.1; Type=Miscellaneous discrepancy; Note=Absence of residues from position 133
within an exon that change the frame which is not the result of an alternative splicing;
Secondary accessions: A6NCZ5 B3KNN0 B4DNM3 Q6PK52 Q96KC7 Q9NSX1
Alternative splicing: 4 isoforms:  Q9NYR9-1   Q9NYR9-2   Q9NYR9-3   Q9NYR9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NKIRAS2: NX_Q9NYR9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYR9

    • NKIRAS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001001349.1  NP_001138399.1  NP_001138400.1  NP_001138401.1  NP_060065.2  

    ENSEMBL proteins: 
     ENSP00000468081   ENSP00000303580   ENSP00000377463   ENSP00000468245   ENSP00000466135  
     ENSP00000465633   ENSP00000377458   ENSP00000377459   ENSP00000419929   ENSP00000465588  
     ENSP00000401976   ENSP00000312773   ENSP00000377462  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): NKIRAS2
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    Novus Biologicals NKIRAS2 Proteins
    Novus Biologicals NKIRAS2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NKIRAS2
    Uscn Proteins for NKIRAS2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--


    NKIRAS2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NKIRAS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NKIRAS2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9NYR9

    ProtoNet protein and cluster: Q9NYR9

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9
    Domain: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the
    conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and
    are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this
    family are clearly different from other small GTPases proteins
    Similarity: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily


    Function
    for NKIRAS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9
    Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
    degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
    degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It
    is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity)

    miRNA
    Products:            		miRTarBase miRNAs that target NKIRAS2:
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    hsa-let-7d hsa-miR-29a hsa-miR-3653 hsa-miR-3161 hsa-let-7g hsa-let-7a hsa-miR-4325 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmid: NKIRAS2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: NKIRAS2
    OriGene siRNA: NKIRAS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKIRAS2

    Gene Editing
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    Clone
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKIRAS2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10657303
    GO:0005525GTP binding IEA--


    NKIRAS2 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nkiras2):
     vision/eye 

    NKIRAS2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NKIRAS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TNF-alpha/NF-kB Signaling Pathway
    		TNF-alpha/NF-kB Signaling Pathway1.00


    1 BioSystems Pathway for NKIRAS2 
        TNF-alpha/NF-kB Signaling Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKIRAS2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for NKIRAS2 (Q9NYR92, 3 ENSP000003035804) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271355 I2D: score=2 
    SMN2Q166372, 3MINT-8271355 I2D: score=2 
    TK1P041832, 3MINT-8273807 I2D: score=2 
    NFKBIAP259633, ENSP000002167974I2D: score=1 STRING: ENSP00000216797
    NFKBIBQ156533, ENSP000003129884I2D: score=2 STRING: ENSP00000312988
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007249I-kappaB kinase/NF-kappaB cascade NAS10657303
    GO:0007264small GTPase mediated signal transduction IEA--


    NKIRAS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NKIRAS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKIRAS2

    1 HMDB Compound for NKIRAS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about NKIRAS2 / KBRS2 

    Transcripts
    for NKIRAS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NKIRAS2 gene (5 alternative transcripts): 
    NM_001001349.2  NM_001144927.1  NM_001144928.1  NM_001144929.1  NM_017595.5  

    Unigene Cluster for NKIRAS2:

    NFKB inhibitor interacting Ras-like 2
    Hs.632252  [show with all ESTs]
    Unigene Representative Sequence: BC063498
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585955 ENST00000307641(uc002hyq.3) ENST00000393885 ENST00000587337
    ENST00000485789 ENST00000479407 ENST00000393880 ENST00000393881 ENST00000462043
    ENST00000587028 ENST00000491638 ENST00000449471(uc010wgd.2 uc010wge.2)
    ENST00000316082 ENST00000393879 ENST00000393884(uc002hyr.3 uc002hys.3 uc002hyt.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKIRAS2
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate NKIRAS2 (see all 38):
    hsa-let-7d hsa-miR-29a hsa-miR-3653 hsa-miR-3161 hsa-let-7g hsa-let-7a hsa-miR-4325 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmid: NKIRAS2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKIRAS2 (see all 7)
    OriGene shRNA RFP: NKIRAS2
    OriGene siRNA: NKIRAS2
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): NKIRAS2 (NM_001144928)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKIRAS2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKIRAS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKIRAS2

    Additional cDNA sequence: 

    AF229840.1 AK027265.1 AK054571.1 AK297975.1 BC007316.2 BC007450.2 BC009059.1 BC047369.1 
    BC063498.1 

    24/27 DOTS entries (see all 27):

    DT.100791038  DT.100791034  DT.101961705  DT.95143112  DT.100791037  DT.120967382  DT.100791033  DT.446442 
    DT.120967366  DT.95143111  DT.95211743  DT.92451426  DT.100815292  DT.100705586  DT.100638705  DT.97859316 
    DT.120967431  DT.120967457  DT.40300640  DT.100032622  DT.100033703  DT.100791032  DT.100791043  DT.120967528 

    24/324 AceView cDNA sequences (see all 324):

    T17464 BU787576 AA356283 AU280166 BM697900 BU931632 BU194047 BM666061 
    BE261602 BG987733 AK054571 AI623807 CR595468 AI890461 AA669831 AA453563 
    AF229840 BQ214765 BQ641886 BQ679699 BX106191 BM710962 AI818040 BE504700 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NKIRAS2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
    SP1:                                -     -           -     -                                                               
    SP2:                                -     -           -     -                                                               
    SP3:        -     -     -     -     -     -           -     -                                                               
    SP4:                                -     -           -     -                                                               
    SP5:                                -                 -     -                                                               


    ECgene alternative splicing isoforms for NKIRAS2

    Expression
    for NKIRAS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKIRAS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGAAGGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NKIRAS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    HeartOutflow TractHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NKIRAS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKIRAS2

    SOURCE GeneReport for Unigene cluster: Hs.632252

    UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for NKIRAS2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKIRAS2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKIRAS2

    Orthologs
    for NKIRAS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NKIRAS2 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NKIRAS21 NFKB inhibitor interacting Ras-like 2 82.37(n)
    92.67(a)    		   420032  NM_001006333.1  NP_001006333.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NKIRAS26
    		 --
    		 92(a)
    		 1 ↔ 1
    		 6(66354573-66357599)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX731228.12   -- 78.38(n)    BX731228.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005380461 NF-kappa-B inhibitor-interacting Ras-like protein 2-like 73.68(n)
    78.95(a)    		   100538046  XM_003198081.1  XP_003198129.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta kappaB-Ras6
    		 kappaB-Ras
    		 38(a)
    		 1 → many
    		 2R(3331329-3333266)
    worm
    (Caenorhabditis elegans)    		 Secernentea F52A8.66
    		 NF-kappa-B inhibitor-interacting Ras-like protein
    		 21(a)
    		 1 → many
    		 I(7347220-7350384)


    ENSEMBL Gene Tree for NKIRAS2 (if available)
    TreeFam Gene Tree for NKIRAS2 (if available) 

    Paralogs
    for NKIRAS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKIRAS2 gene
    NKIRAS12  
    12 SIMAP similar genes for NKIRAS2 using alignment to 7 protein entries:     KBRS2_HUMAN (see all proteins):
    NKIRAS1    PFKFB3    RRAS2    MRAS    MST132    RAP1B
    TUBA1C    RAP2A    RALB    c-bas/has    KRAS    NRAS

    NKIRAS2 for paralogs           About GeneDecksing



    Genomic Variants
    for NKIRAS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/97 NCBI SNPs in NKIRAS2 are shown (see all 97)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1836759041,2
    		--40171732(+) AGCTTC/TTCTAG 5 -- us2k1 int10--------
    rs798929251,2
    		F,--40171819(+) GACAGA/GTGATG 5 -- us2k1 int12Minor allele frequency- G:0.11WA NA 238
    rs1459817111,2
    		--40171833(+) AGAAAA/CCATTT 5 -- us2k1 int10--------
    rs1486408481,2
    		--40172228(+) GTACGA/GACCTG 5 -- int10--------
    rs283727861,2
    		--40172232(+) GGACCC/TGGGAG 5 -- int10--------
    rs126032061,2
    		C,H--40172287(+) CTTTAG/AGTGGC 5 -- int16Minor allele frequency- A:0.00NS EA NA 394
    rs1908834541,2
    		C,--40172447(+) TGTTAA/GGGACC 5 -- int10--------
    rs80821531,2
    		C,F,A,H,--40172467(+) AGTGAT/CCTATC 5 -- int115Minor allele frequency- C:0.11NS NA WA 1852
    rs1823202321,2
    		--40172561(+) GACCTC/TTTAGG 5 -- int10--------
    rs1866799641,2
    		--40172586(+) GCTTTC/TTCTTT 5 -- int10--------

    HapMap Linkage Disequilibrium report for NKIRAS2 (40163400 - 40177659 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NKIRAS2: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for NKIRAS2

    Disorders / Diseases
    for NKIRAS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NKIRAS2 for disorders           About GeneDecksing

    OMIM gene information: 604497    OMIM disorders: --

    3 diseases for NKIRAS2:    About MalaCards
    sezary's disease    rheumatoid arthritis    arthritis

    Human Genome Epidemiology (HuGE) Navigator: NKIRAS2 (1 document)

    Export disorders for NKIRAS2 gene to outside databases

    Publications
    for NKIRAS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKIRAS2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with NKIRAS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)1, 2, 3 Fenwick C....Ghosh S. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activ ation of p65/RelA. (PubMed id 20639196)1 Tago K....Itoh H. (2010)
    9. Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1 Dieguez-Gonzalez R....Gonzalez A. (2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    External Searches for NKIRAS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NKIRAS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28511 HGNC: 17898 AceView: NKIRAS2 Ensembl:ENSG00000168256 euGenes: HUgn28511
    ECgene: NKIRAS2 H-InvDB: NKIRAS2

    Other Databases showing NKIRAS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NKIRAS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKIRAS2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NKIRAS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NKIRAS2 gene:
    Search GeneIP for patents involving NKIRAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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