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Aliases for NKIRAS2 Gene

Aliases for NKIRAS2 Gene

  • NFKB Inhibitor Interacting Ras-Like 2 2 3
  • NFKB Inhibitor Interacting Ras-Like Protein 2 2 3
  • I-Kappa-B-Interacting Ras-Like Protein 2 3 4
  • Kappa B-Ras Protein 2 3 4
  • KappaB-Ras2 3 4
  • KBRAS2 3 4
  • NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 2 3

External Ids for NKIRAS2 Gene

Summaries for NKIRAS2 Gene

GeneCards Summary for NKIRAS2 Gene

NKIRAS2 (NFKB Inhibitor Interacting Ras-Like 2) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS1.

UniProtKB/Swiss-Prot for NKIRAS2 Gene

  • Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

Gene Wiki entry for NKIRAS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKIRAS2 Gene

Genomics for NKIRAS2 Gene

Genomic Location for NKIRAS2 Gene

Start:
42,011,382 bp from pter
End:
42,025,644 bp from pter
Size:
14,263 bases
Orientation:
Plus strand

Genomic View for NKIRAS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKIRAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKIRAS2 Gene

Regulatory Elements for NKIRAS2 Gene

Proteins for NKIRAS2 Gene

  • Protein details for NKIRAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYR9-KBRS2_HUMAN
    Recommended name:
    NF-kappa-B inhibitor-interacting Ras-like protein 2
    Protein Accession:
    Q9NYR9
    Secondary Accessions:
    • A6NCZ5
    • B3KNN0
    • B4DNM3
    • Q6PK52
    • Q96KC7
    • Q9NSX1

    Protein attributes for NKIRAS2 Gene

    Size:
    191 amino acids
    Molecular mass:
    21508 Da
    Quaternary structure:
    • Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo.
    SequenceCaution:
    • Sequence=BAB55006.1; Type=Miscellaneous discrepancy; Note=Absence of residues from position 133 within an exon that change the frame which is not the result of an alternative splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for NKIRAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKIRAS2 Gene

Proteomics data for NKIRAS2 Gene at MOPED

Post-translational modifications for NKIRAS2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys167 and Lys174

No data available for DME Specific Peptides for NKIRAS2 Gene

Domains for NKIRAS2 Gene

UniProtKB/Swiss-Prot:

KBRS2_HUMAN
Domain:
  • In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins:
    • Q9NYR9
Family:
  • Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.:
    • Q9NYR9
genes like me logo Genes that share domains with NKIRAS2: view

No data available for Gene Families for NKIRAS2 Gene

Function for NKIRAS2 Gene

Molecular function for NKIRAS2 Gene

UniProtKB/Swiss-Prot Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

Gene Ontology (GO) - Molecular Function for NKIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10657303
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with NKIRAS2: view

Phenotypes for NKIRAS2 Gene

MGI mutant phenotypes for NKIRAS2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NKIRAS2: view

miRNA for NKIRAS2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NKIRAS2 Gene

Localization for NKIRAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKIRAS2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKIRAS2 Gene COMPARTMENTS Subcellular localization image for NKIRAS2 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NKIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NKIRAS2: view

Pathways for NKIRAS2 Gene

genes like me logo Genes that share pathways with NKIRAS2: view

Pathways by source for NKIRAS2 Gene

1 Qiagen pathway for NKIRAS2 Gene
1 BioSystems pathway for NKIRAS2 Gene

Gene Ontology (GO) - Biological Process for NKIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007249 I-kappaB kinase/NF-kappaB signaling NAS 10657303
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008152 metabolic process NAS 10657303
genes like me logo Genes that share ontologies with NKIRAS2: view

Compounds for NKIRAS2 Gene

(1) HMDB Compounds for NKIRAS2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with NKIRAS2: view

Transcripts for NKIRAS2 Gene

Unigene Clusters for NKIRAS2 Gene

NFKB inhibitor interacting Ras-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKIRAS2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - -

Relevant External Links for NKIRAS2 Gene

GeneLoc Exon Structure for
NKIRAS2
ECgene alternative splicing isoforms for
NKIRAS2

Expression for NKIRAS2 Gene

mRNA expression in normal human tissues for NKIRAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NKIRAS2 Gene

SOURCE GeneReport for Unigene cluster for NKIRAS2 Gene Hs.632252

mRNA Expression by UniProt/SwissProt for NKIRAS2 Gene

Q9NYR9-KBRS2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with NKIRAS2: view

Orthologs for NKIRAS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKIRAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKIRAS2 36
  • 100 (n)
  • 100 (a)
NKIRAS2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKIRAS2 36
  • 93.19 (n)
  • 100 (a)
NKIRAS2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKIRAS2 36
  • 92.67 (n)
  • 100 (a)
NKIRAS2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkiras2 36
  • 90.92 (n)
  • 98.95 (a)
Nkiras2 16
Nkiras2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKIRAS2 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKIRAS2 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkiras2 36
  • 90.75 (n)
  • 98.95 (a)
chicken
(Gallus gallus)
Aves NKIRAS2 36
  • 82.37 (n)
  • 92.67 (a)
NKIRAS2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKIRAS2 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkiras2 36
  • 75.84 (n)
  • 81.48 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100538046 36
  • 73.68 (n)
  • 78.95 (a)
nkiras2 37
  • 77 (a)
OneToMany
nkiras2 37
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta kappaB-Ras 37
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52A8.6 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToMany
Species with no ortholog for NKIRAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKIRAS2 Gene

ENSEMBL:
Gene Tree for NKIRAS2 (if available)
TreeFam:
Gene Tree for NKIRAS2 (if available)

Paralogs for NKIRAS2 Gene

Paralogs for NKIRAS2 Gene

genes like me logo Genes that share paralogs with NKIRAS2: view

Variants for NKIRAS2 Gene

Sequence variations from dbSNP and Humsavar for NKIRAS2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs5022678 -- 42,024,599(+) GAAAC(C/G)CCATC utr-variant-3-prime
rs5820440 -- 42,024,777(+) TCGAA(A/G)AAAAA utr-variant-3-prime
rs11540536 -- 42,024,573(+) TTCAC(G/T)ACCAG utr-variant-3-prime
rs11540538 -- 42,024,111(+) TCCCC(A/C)TCCCA utr-variant-3-prime
rs34627459 -- 42,023,519(+) GTGGT(A/G)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKIRAS2 Gene

Variant ID Type Subtype PubMed ID
nsv908240 CNV Loss 21882294

Relevant External Links for NKIRAS2 Gene

HapMap Linkage Disequilibrium report
NKIRAS2

Disorders for NKIRAS2 Gene

Relevant External Links for NKIRAS2

Genetic Association Database (GAD)
NKIRAS2
Human Genome Epidemiology (HuGE) Navigator
NKIRAS2
genes like me logo Genes that share disorders with NKIRAS2: view

No data available for UniProtKB/Swiss-Prot for NKIRAS2 Gene

Publications for NKIRAS2 Gene

  1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PMID: 10657303) Fenwick C. … Ghosh S. (Science 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 49
  5. KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA. (PMID: 20639196) Tago K. … Itoh H. (J. Biol. Chem. 2010) 3

Products for NKIRAS2 Gene

Sources for NKIRAS2 Gene

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