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NKIRAS2 Gene

protein-coding   GIFtS: 57
GCID: GC17P040170

NFKB Inhibitor Interacting Ras-Like 2

(Previous name: NFKB inhibitor interacting Ras-like protein 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NFKB Inhibitor Interacting Ras-Like 21 2     I-Kappa-B-Interacting Ras-Like Protein 22 3
NFKB Inhibitor Interacting Ras-Like Protein 21 2     kappaB-Ras22
Kappa B-Ras Protein 22 3     NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 22
KBRAS22 3     KappaB-Ras23

External Ids:    HGNC: 178981   Entrez Gene: 285112   Ensembl: ENSG000001682567   OMIM: 6044975   UniProtKB: Q9NYR93   

Export aliases for NKIRAS2 gene to outside databases

Previous GC identifers: GC17P040546 GC17P037422 GC17P035934


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NKIRAS2 Gene:
NKIRAS2 (NFKB inhibitor interacting Ras-like 2) is a protein-coding gene. Diseases associated with NKIRAS2 include sezary's disease, and rheumatoid arthritis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS1.

UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9
Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B
subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB
(By similarity)

Gene Wiki entry for NKIRAS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKIRAS2 gene promoter:
         p53   NRSF form 1   CUTL1   NRSF form 2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKIRAS2 promoter sequence
   Search Chromatin IP Primers for NKIRAS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKIRAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.31

NKIRAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKIRAS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040170:  view genomic region     (about GC identifiers)

Start:
40,163,400 bp from pter      End:
40,177,659 bp from pter
Size:
14,260 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003571052 304,218-312,283     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor-interacting Ras-like protein 2  
Size: 191 amino acids; 21508 Da
Subunit: Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably
only interacts with NFKBIB in vivo
Sequence caution: Sequence=BAB55006.1; Type=Miscellaneous discrepancy; Note=Absence of residues from position 133
within an exon that change the frame which is not the result of an alternative splicing;
Secondary accessions: A6NCZ5 B3KNN0 B4DNM3 Q6PK52 Q96KC7 Q9NSX1
Alternative splicing: 4 isoforms:  Q9NYR9-1   Q9NYR9-2   Q9NYR9-3   Q9NYR9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NKIRAS2: NX_Q9NYR9

Explore proteomics data for NKIRAS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys167, Lys174
  • Modification sites at PhosphoSitePlus

  • See NKIRAS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001001349.1  NP_001138399.1  NP_001138400.1  NP_001138401.1  NP_060065.2  

    ENSEMBL proteins: 
     ENSP00000468081   ENSP00000303580   ENSP00000377463   ENSP00000468245   ENSP00000466135  
     ENSP00000465633   ENSP00000377458   ENSP00000377459   ENSP00000419929   ENSP00000465588  
     ENSP00000401976   ENSP00000312773   ENSP00000377462  

    NKIRAS2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9NYR9

    ProtoNet protein and cluster: Q9NYR9

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9
    Domain: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the
    conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively,
    and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that
    members of this family are clearly different from other small GTPases proteins
    Similarity: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily


    NKIRAS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KBRS2_HUMAN, Q9NYR9
    Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
    degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
    degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B
    subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10657303
    GO:0005525GTP binding IEA--
         
    NKIRAS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nkiras2):
     vision/eye 

    NKIRAS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKIRAS2
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    miRNA
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    miRTarBase miRNAs that target NKIRAS2:
    hsa-mir-125b-5p (MIRT000462), hsa-mir-29b-3p (MIRT006915), hsa-mir-29c-3p (MIRT020388), hsa-let-7a-5p (MIRT000463), hsa-mir-96-5p (MIRT027902)

    Block miRNA regulation of human, mouse, rat NKIRAS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NKIRAS2 (see all 38):
    hsa-let-7d hsa-miR-29a hsa-miR-3653 hsa-miR-3161 hsa-let-7g hsa-let-7a hsa-miR-4325 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidNKIRAS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NKIRAS2

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    GenScript: all cDNA clones in your preferred vector (see all 5): NKIRAS2 (NM_001144928)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKIRAS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KBRS2_HUMAN, Q9NYR9: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    NKIRAS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NKIRAS2 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NKIRAS2
        NF-KappaB Family Pathway

    1 BioSystems Pathway for NKIRAS2
        TNF-alpha/NF-kB Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKIRAS2
    Interactions:

        Search GeneGlobe Interaction Network for NKIRAS2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for NKIRAS2 (Q9NYR92, 3 ENSP000003035804) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271355 I2D: score=2 
    SMN2Q166372, 3MINT-8271355 I2D: score=2 
    TK1P041832, 3MINT-8273807 I2D: score=2 
    NFKBIAP259633, ENSP000002167974I2D: score=1 STRING: ENSP00000216797
    NFKBIBQ156533, ENSP000003129884I2D: score=2 STRING: ENSP00000312988
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007249I-kappaB kinase/NF-kappaB signaling NAS10657303
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    NKIRAS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NKIRAS2 (KBRS2)

    1 HMDB Compound for NKIRAS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NKIRAS2 gene (5 alternative transcripts): 
    NM_001001349.2  NM_001144927.1  NM_001144928.1  NM_001144929.1  NM_017595.5  

    Unigene Cluster for NKIRAS2:

    NFKB inhibitor interacting Ras-like 2
    Hs.632252  [show with all ESTs]
    Unigene Representative Sequence: BC063498
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585955 ENST00000307641(uc002hyq.3) ENST00000393885 ENST00000587337
    ENST00000485789 ENST00000479407 ENST00000393880 ENST00000393881 ENST00000462043
    ENST00000587028 ENST00000491638 ENST00000449471(uc010wgd.2 uc010wge.2)
    ENST00000316082 ENST00000393879 ENST00000393884(uc002hyr.3 uc002hys.3 uc002hyt.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NKIRAS2 (see all 38):
    hsa-let-7d hsa-miR-29a hsa-miR-3653 hsa-miR-3161 hsa-let-7g hsa-let-7a hsa-miR-4325 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidNKIRAS2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NKIRAS2
      QuantiFast Probe-based Assays in human, mouse, rat NKIRAS2

    Additional mRNA sequence: 

    AF229840.1 AK027265.1 AK054571.1 AK297975.1 BC007316.2 BC007450.2 BC009059.1 BC047369.1 
    BC063498.1 

    Selected DOTS entries (see all 27):

    DT.100791038  DT.100791034  DT.101961705  DT.95143112  DT.100791037  DT.120967382  DT.100791033  DT.446442 
    DT.120967366  DT.95143111  DT.95211743  DT.92451426  DT.100815292  DT.100705586  DT.100638705  DT.97859316 
    DT.120967431  DT.120967457  DT.40300640  DT.100032622  DT.100033703  DT.100791032  DT.100791043  DT.120967528 

    Selected AceView cDNA sequences (see all 324):

    BQ214765 NM_017595 BU178284 AI623807 BQ883174 AK054571 AI432582 BE047113 
    BM697900 AW872914 BE261602 BQ641886 BE409332 BM973373 BU787576 CD515548 
    BQ086145 AA669831 AI160345 BI754729 CR595468 BM468757 CA454499 CR618051 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NKIRAS2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
    SP1:                                -     -           -     -                                                               
    SP2:                                -     -           -     -                                                               
    SP3:        -     -     -     -     -     -           -     -                                                               
    SP4:                                -     -           -     -                                                               
    SP5:                                -                 -     -                                                               


    ECgene alternative splicing isoforms for NKIRAS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NKIRAS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAGGCTG
    NKIRAS2 Expression
    About this image


    NKIRAS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
    NKIRAS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NKIRAS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632252

    UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9
    Tissue specificity: Widely expressed

        Custom PCR Arrays for NKIRAS2
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    QuantiFast Probe-based Assays in human, mouse, rat NKIRAS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKIRAS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NKIRAS2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkiras21 , 5 NFKB inhibitor interacting Ras-like protein 21, 5 90.92(n)1
    98.95(a)1
      11 (63.47 cM)5
    719661  NM_028024.21  NP_082300.11 
     1006192445 
    chicken
    (Gallus gallus)
    Aves NKIRAS21 NFKB inhibitor interacting Ras-like 2 82.37(n)
    92.67(a)
      420032  NM_001006333.1  NP_001006333.1 
    lizard
    (Anolis carolinensis)
    Reptilia NKIRAS26
    NFKB inhibitor interacting Ras-like 2
    81(a)
    1 ↔ 1
    6(66354573-66361665)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX731228.12   -- 78.38(n)    BX731228.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005380461 NF-kappa-B inhibitor-interacting Ras-like protein 2-like 73.68(n)
    78.95(a)
      100538046  XM_003198081.2  XP_003198129.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kappaB-Ras6
    kappaB-Ras
    37(a)
    1 → many
    2R(3331329-3333266)
    worm
    (Caenorhabditis elegans)
    Secernentea F52A8.66
    Protein F52A8.6, isoform a
    21(a)
    1 → many
    I(7347222-7350386) WBGene00009919


    ENSEMBL Gene Tree for NKIRAS2 (if available)
    TreeFam Gene Tree for NKIRAS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NKIRAS2 gene
    NKIRAS12  
    12 SIMAP similar genes for NKIRAS2 using alignment to 7 protein entries:     KBRS2_HUMAN (see all proteins):
    NKIRAS1    PFKFB3    RRAS2    MRAS    MST132    RAP1B
    TUBA1C    RAP2A    RALB    c-bas/has    KRAS    NRAS

    NKIRAS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NKIRAS2 (see all 117)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836759041,2
    --40171732(+) AGCTTC/TTCTAG 5 -- int1 us2k10--------
    rs798929251,2
    C,F--40171819(+) GACAGA/GTGATG 5 -- int1 us2k12Minor allele frequency- G:0.11WA NA 238
    rs1459817111,2
    C--40171833(+) AGAAAA/CCATTT 5 -- int1 us2k10--------
    rs1486408481,2
    --40172228(+) GTACGA/GACCTG 5 -- int10--------
    rs283727861,2
    --40172232(+) GGACCC/TGGGAG 5 -- int10--------
    rs126032061,2
    C,H--40172287(+) CTTTAG/AGTGGC 5 -- int16Minor allele frequency- A:0.00NS EA NA 394
    rs1908834541,2
    C--40172447(+) TGTTAA/GGGACC 5 -- int10--------
    rs80821531,2
    C,F,A,H--40172467(+) AGTGAT/CCTATC 5 -- int115Minor allele frequency- C:0.11NS NA WA 1852
    rs1823202321,2
    --40172561(+) GACCTC/TTTAGG 5 -- int10--------
    rs1866799641,2
    --40172586(+) GCTTTC/TTCTTT 5 -- int10--------

    HapMap Linkage Disequilibrium report for NKIRAS2 (40163400 - 40177659 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NKIRAS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908240CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NKIRAS2
    DNA2.0 Custom Variant and Variant Library Synthesis for NKIRAS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604497    OMIM disorders: --

    3 diseases for NKIRAS2:    
    About MalaCards
    sezary's disease    rheumatoid arthritis    arthritis


    NKIRAS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NKIRAS2
    Human Genome Epidemiology (HuGE) Navigator: NKIRAS2 (1 document)

    Export disorders for NKIRAS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKIRAS2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with NKIRAS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)1, 2, 3 Fenwick C....Ghosh S. (Science 2000)
    2. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4 Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA. (PubMed id 20639196)1 Tago K....Itoh H. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28511 HGNC: 17898 AceView: NKIRAS2 Ensembl:ENSG00000168256 euGenes: HUgn28511
    ECgene: NKIRAS2 H-InvDB: NKIRAS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NKIRAS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NKIRAS2 gene:
    Search GeneIP for patents involving NKIRAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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