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Aliases for NKIRAS1 Gene

Aliases for NKIRAS1 Gene

  • NFKB Inhibitor Interacting Ras Like 1 2 3 5
  • NFKB Inhibitor Interacting Ras-Like Protein 1 2 3
  • I-Kappa-B-Interacting Ras-Like Protein 1 3 4
  • Kappa B-Ras Protein 1 3 4
  • KappaB-Ras1 3 4
  • KBRAS1 3 4
  • NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 1 3
  • Kappa B-Ras 1 3

External Ids for NKIRAS1 Gene

Previous GeneCards Identifiers for NKIRAS1 Gene

  • GC03M023908
  • GC03M023933
  • GC03M023879

Summaries for NKIRAS1 Gene

GeneCards Summary for NKIRAS1 Gene

NKIRAS1 (NFKB Inhibitor Interacting Ras Like 1) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS2.

UniProtKB/Swiss-Prot for NKIRAS1 Gene

  • Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKIRAS1 Gene

Genomics for NKIRAS1 Gene

Regulatory Elements for NKIRAS1 Gene

Enhancers for NKIRAS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F023888 0.6 ENCODE 13.3 +57.8 57797 0.1 CTCF ZNF654 TRIM22 REST RAD21 ATF3 THRAP3 SMC3 ZNF143 ZNF24 RPL15 NKIRAS1 NR1D2 UBE2E1 UBE2E1-AS1 PIR33503 ARL4AP4
GH03F023915 0.5 ENCODE 13.1 +29.4 29377 4.1 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 RPL24P7 NKIRAS1 NR1D2 RPL15
GH03F023968 0.2 ENCODE 12.2 -22.0 -22014 0.1 JUN CEBPB EP300 JUND FOS PRDM10 NFE2L2 ZNF558 NKIRAS1 NR1D2 RPL15 NPM1P23
GH03F023987 0.6 Ensembl 11.9 -40.8 -40810 0.4 SCRT1 SCRT2 NKIRAS1 NR1D2 RPL15 NPM1P23
GH03F023875 0.8 Ensembl ENCODE 11.7 +69.6 69645 2.7 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 RPL24P7 UBE2E1 UBE2E1-AS1 RPL15 NKIRAS1 NR1D2 ARL4AP4 GC03M023860
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NKIRAS1 on UCSC Golden Path with GeneCards custom track

Promoters for NKIRAS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001673343 791 2801 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 CBX5 ZNF143 ZNF207

Genomic Location for NKIRAS1 Gene

Chromosome:
3
Start:
23,891,660 bp from pter
End:
23,946,591 bp from pter
Size:
54,932 bases
Orientation:
Minus strand

Genomic View for NKIRAS1 Gene

Genes around NKIRAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKIRAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKIRAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKIRAS1 Gene

Proteins for NKIRAS1 Gene

  • Protein details for NKIRAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYS0-KBRS1_HUMAN
    Recommended name:
    NF-kappa-B inhibitor-interacting Ras-like protein 1
    Protein Accession:
    Q9NYS0
    Secondary Accessions:
    • Q96K18

    Protein attributes for NKIRAS1 Gene

    Size:
    192 amino acids
    Molecular mass:
    21643 Da
    Quaternary structure:
    • Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also interacts with c-Rel (REL).

neXtProt entry for NKIRAS1 Gene

Post-translational modifications for NKIRAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NKIRAS1 Gene

Domains & Families for NKIRAS1 Gene

Gene Families for NKIRAS1 Gene

Protein Domains for NKIRAS1 Gene

Suggested Antigen Peptide Sequences for NKIRAS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYS0

UniProtKB/Swiss-Prot:

KBRS1_HUMAN :
  • In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
Domain:
  • In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
Family:
  • Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
genes like me logo Genes that share domains with NKIRAS1: view

Function for NKIRAS1 Gene

Molecular function for NKIRAS1 Gene

UniProtKB/Swiss-Prot Function:
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

Gene Ontology (GO) - Molecular Function for NKIRAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10657303
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with NKIRAS1: view
genes like me logo Genes that share phenotypes with NKIRAS1: view

Animal Models for NKIRAS1 Gene

MGI Knock Outs for NKIRAS1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKIRAS1 Gene

Localization for NKIRAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKIRAS1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKIRAS1 Gene COMPARTMENTS Subcellular localization image for NKIRAS1 gene
Compartment Confidence
cytosol 2
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NKIRAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NKIRAS1: view

Pathways & Interactions for NKIRAS1 Gene

SuperPathways for NKIRAS1 Gene

SuperPathway Contained pathways
1 NF-KappaB Family Pathway
genes like me logo Genes that share pathways with NKIRAS1: view

Pathways by source for NKIRAS1 Gene

1 Qiagen pathway for NKIRAS1 Gene

Gene Ontology (GO) - Biological Process for NKIRAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling NAS 10657303
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with NKIRAS1: view

No data available for SIGNOR curated interactions for NKIRAS1 Gene

Drugs & Compounds for NKIRAS1 Gene

(1) Drugs for NKIRAS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with NKIRAS1: view

Transcripts for NKIRAS1 Gene

Unigene Clusters for NKIRAS1 Gene

NFKB inhibitor interacting Ras-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKIRAS1 Gene

No ASD Table

Relevant External Links for NKIRAS1 Gene

GeneLoc Exon Structure for
NKIRAS1
ECgene alternative splicing isoforms for
NKIRAS1

Expression for NKIRAS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NKIRAS1 Gene

Protein differential expression in normal tissues from HIPED for NKIRAS1 Gene

This gene is overexpressed in Bone (18.2), Retina (17.7), and Frontal cortex (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NKIRAS1 Gene



Protein tissue co-expression partners for NKIRAS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NKIRAS1 Gene:

NKIRAS1

SOURCE GeneReport for Unigene cluster for NKIRAS1 Gene:

Hs.173202

mRNA Expression by UniProt/SwissProt for NKIRAS1 Gene:

Q9NYS0-KBRS1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NKIRAS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NKIRAS1 Gene

Orthologs for NKIRAS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKIRAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKIRAS1 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia NKIRAS1 34 35
  • 92.36 (n)
cow
(Bos Taurus)
Mammalia NKIRAS1 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkiras1 34 16 35
  • 86.81 (n)
rat
(Rattus norvegicus)
Mammalia Nkiras1 34
  • 83.85 (n)
oppossum
(Monodelphis domestica)
Mammalia NKIRAS1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKIRAS1 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKIRAS1 34 35
  • 77.49 (n)
lizard
(Anolis carolinensis)
Reptilia NKIRAS1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkiras1 34
  • 72.92 (n)
zebrafish
(Danio rerio)
Actinopterygii nkiras1 34 35
  • 68.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta kappaB-Ras 34 35
  • 51.31 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011283 34
  • 51.25 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_F52A8.6 34
  • 49.73 (n)
F52A8.6 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
Species where no ortholog for NKIRAS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKIRAS1 Gene

ENSEMBL:
Gene Tree for NKIRAS1 (if available)
TreeFam:
Gene Tree for NKIRAS1 (if available)

Paralogs for NKIRAS1 Gene

Paralogs for NKIRAS1 Gene

(14) SIMAP similar genes for NKIRAS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NKIRAS1: view

Variants for NKIRAS1 Gene

Sequence variations from dbSNP and Humsavar for NKIRAS1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10533552 -- 23,891,688(+) TGTCT(-/CT)TTCAG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs10539103 -- 23,893,965(+) TGTAT(-/GA)GAGAT intron-variant
rs111230172 -- 23,917,524(+) TCCTG(A/T)GATGT intron-variant, upstream-variant-2KB
rs11129127 -- 23,901,915(+) TAAAA(A/T)TACAA intron-variant
rs111346505 -- 23,902,230(+) AGAAT(A/G)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKIRAS1 Gene

Variant ID Type Subtype PubMed ID
nsv1005186 CNV gain 25217958

Variation tolerance for NKIRAS1 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKIRAS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKIRAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKIRAS1 Gene

Disorders for NKIRAS1 Gene

Relevant External Links for NKIRAS1

Genetic Association Database (GAD)
NKIRAS1
Human Genome Epidemiology (HuGE) Navigator
NKIRAS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKIRAS1

No disorders were found for NKIRAS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKIRAS1 Gene

Publications for NKIRAS1 Gene

  1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PMID: 10657303) Fenwick C. … Ghosh S. (Science 2000) 2 3 4 22 64
  2. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 22 46 64
  3. Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas. (PMID: 20693965) Gerashchenko G.V. … Kashuba V.I. (Exp. Oncol. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PMID: 15024091) Chen Y. … Ghosh G. (Mol. Cell. Biol. 2004) 3 4 64

Products for NKIRAS1 Gene

Sources for NKIRAS1 Gene

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