Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKIRAS1 Gene

protein-coding   GIFtS: 51
GCID: GC03M023933

NFKB Inhibitor Interacting Ras-Like 1

(Previous name: NFKB inhibitor interacting Ras-like protein 1)
  4 related diseases
at
MalaCards
 

Aliases
for NKIRAS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
NFKB Inhibitor Interacting Ras-Like 11 2     Kappa B-Ras 12
NFKB Inhibitor Interacting Ras-Like Protein 11 2     kappaB-Ras12
Kappa B-Ras Protein 12 3     NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 12
KBRAS12 3     KappaB-Ras13
I-Kappa-B-Interacting Ras-Like Protein 12 3     

External Ids:    HGNC: 178991   Entrez Gene: 285122   Ensembl: ENSG000001978857   OMIM: 6044965   UniProtKB: Q9NYS03   

Export aliases for NKIRAS1 gene to outside databases

Previous GC identifers: GC03M023908 GC03M023879


Summaries
for NKIRAS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for NKIRAS1 Gene: 
NKIRAS1 (NFKB inhibitor interacting Ras-like 1) is a protein-coding gene. Diseases associated with NKIRAS1 include renal cell carcinoma, and rheumatoid arthritis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS2.

UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B
subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB




Genomic Views
for NKIRAS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKIRAS1 gene promoter:
         AML1a   NRSF form 1   NRSF form 2   NF-kappaB   C/EBPalpha   FOXJ2 (long isoform)   FOXJ2   Msx-1   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKIRAS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKIRAS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKIRAS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.2   HGNC cytogenetic band: 3p24.1

NKIRAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKIRAS1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M023933:  view genomic region     (about GC identifiers)

Start:
 23,933,151 bp from pter      End:
 23,988,082 bp from pter
Size:
 54,932 bases      Orientation:
 minus strand

Proteins
for NKIRAS1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor-interacting Ras-like protein 1  
Size: 192 amino acids; 21643 Da
Subunit: Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only
interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also
interacts with c-Rel (REL)
Subcellular location: Cytoplasm
Secondary accessions: Q96K18

Explore the universe of human proteins at neXtProt for NKIRAS1: NX_Q9NYS0

Explore proteomics data for NKIRAS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYS0

    • NKIRAS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NKIRAS1 Protein Expression
    REFSEQ proteins: NP_065078.1  
    ENSEMBL proteins: 
     ENSP00000373411   ENSP00000393785   ENSP00000392307   ENSP00000400385   ENSP00000406543  
     ENSP00000396063   ENSP00000415225   ENSP00000394214  

    Human Recombinant Protein Products for NKIRAS1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NKIRAS1
    OriGene Protein Over-expression Lysate for NKIRAS1
    OriGene MassSpec for NKIRAS1 
    OriGene Custom Protein Services for NKIRAS1
    GenScript Custom Purified and Recombinant Proteins Services for NKIRAS1
    Novus Biologicals NKIRAS1 Proteins
    Novus Biologicals NKIRAS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NKIRAS1
    Cloud-Clone Corp. Proteins for NKIRAS1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    NKIRAS1 for ontologies           About GeneDecksing



    NKIRAS1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NKIRAS1
    OriGene Custom Antibody Services for NKIRAS1
    GenScript Custom Superior Antibodies Services for NKIRAS1
    Novus Biologicals NKIRAS1 Antibodies
    Abcam antibodies for NKIRAS1
    Cloud-Clone Corp. Antibodies for NKIRAS1 
    ThermoFisher Antibodies for NKIRAS1
    LSBio Antibodies in human, mouse, rat for NKIRAS1 

    Assay Products for NKIRAS1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NKIRAS1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NKIRAS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NKIRAS1 
    Cloud-Clone Corp. CLIAs for NKIRAS1

    Protein Domains /
    Families
    for NKIRAS1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9NYS0

    ProtoNet protein and cluster: Q9NYS0

    UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
    Domain: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the
    conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar
    to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly
    different from other small GTPases proteins
    Similarity: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily


    NKIRAS1 for domains           About GeneDecksing


    Function
    for NKIRAS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KBRS1_HUMAN, Q9NYS0
    Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
    degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
    degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B
    subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10657303
    GO:0005525GTP binding IEA--
         
    NKIRAS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nkiras1):
     no phenotypic analysis 

    NKIRAS1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Nkiras1tm1Brs for NKIRAS1
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NKIRAS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NKIRAS1

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKIRAS1
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NKIRAS1 (see all 14):
    hsa-miR-607 hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-4272 hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: NKIRAS1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NKIRAS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKIRAS1
    Sirion Biotech Custom design and validation of potent shRNA sequences against NKIRAS1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NKIRAS1
    Sirion Biotech Customized adenovirus for overexpression of NKIRAS1
                         Customized adenovirus for potent knockdown of NKIRAS1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NKIRAS1 (see all 7)
    OriGene ORF clones in mouse, rat for NKIRAS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NKIRAS1 (NM_020345)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKIRAS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKIRAS1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NKIRAS1
    Search LifeMap BioReagents cell lines for NKIRAS1
    Sirion Biotech Customized stable knockdown cell line services for NKIRAS1
                         Customized inducible knockdown cell line services for NKIRAS1
                         Customized stable overexpressing cell line services for NKIRAS1
                         Customized inducible overexpressing cell line services for NKIRAS1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKIRAS1


    Pathways & Interactions
    for NKIRAS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NKIRAS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    		TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for NKIRAS1
        TNF-alpha/NF-kB Signaling Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKIRAS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/17 Interacting proteins for NKIRAS1 (Q9NYS03 ENSP000003734114) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    NFKBIBQ156533, ENSP000003129884I2D: score=3 STRING: ENSP00000312988
    NFKBIAP259633, ENSP000002167974I2D: score=2 STRING: ENSP00000216797
    BMPR1BO002383, ENSP000002645684I2D: score=3 STRING: ENSP00000264568
    SMURF2Q9HAU43, ENSP000002624354I2D: score=2 STRING: ENSP00000262435
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007249I-kappaB kinase/NF-kappaB cascade NAS10657303
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    NKIRAS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NKIRAS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKIRAS1 (KBRS1)

    1 HMDB Compound for NKIRAS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about NKIRAS1 / KBRS1

    Transcripts
    for NKIRAS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NKIRAS1 gene: 
    NM_020345.3  

    Unigene Cluster for NKIRAS1:

    NFKB inhibitor interacting Ras-like 1
    Hs.173202  [show with all ESTs]
    Unigene Representative Sequence: NM_020345
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388759 ENST00000443659 ENST00000421515(uc003cck.3) ENST00000425478(uc003ccj.3)
    ENST00000437230 ENST00000412028 ENST00000415901 ENST00000416026
    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKIRAS1
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NKIRAS1 (see all 14):
    hsa-miR-607 hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-4272 hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: NKIRAS1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NKIRAS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKIRAS1
    Sirion Biotech Custom design and validation of potent shRNA sequences against NKIRAS1
    Clone
    Products:             		 OriGene clones in human, mouse for NKIRAS1 (see all 7)
    OriGene ORF clones in mouse, rat for NKIRAS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NKIRAS1 (NM_020345)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKIRAS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKIRAS1
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for NKIRAS1
    OriGene qSTAR qPCR primer pairs in human, mouse for NKIRAS1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NKIRAS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKIRAS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKIRAS1

    Additional mRNA sequence: 

    AF229839.1 AK027749.1 BC012145.1 BC066940.1 BC150589.1 

    7 DOTS entries:

    DT.100811879  DT.100811882  DT.120901956  DT.97822718  DT.100811880  DT.102839491  DT.120902089 

    24/93 AceView cDNA sequences (see all 93):

    BC012145 AA010575 AI187968 AA010714 AW002634 AI302092 CR602142 AI470823 
    BM696013 BE504686 N79148 CA429686 AA551591 CA426818 CR606911 NM_020345 
    AA458628 AA370473 CR600782 AF229839 BG108552 BG481114 BG713995 W47637 

    GeneLoc Exon Structure


    Expression
    for NKIRAS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKIRAS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGAGGTA
    NKIRAS1 Expression
    About this image


    See NKIRAS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKIRAS1

    SOURCE GeneReport for Unigene cluster: Hs.173202

    UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for NKIRAS1
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for NKIRAS1
    OriGene qSTAR qPCR primer pairs in human, mouse for NKIRAS1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NKIRAS1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKIRAS1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKIRAS1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKIRAS1

    Orthologs
    for NKIRAS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NKIRAS1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nkiras11 , 5 NFKB inhibitor interacting Ras-like protein 11, 5 86.81(n)1
    95.31(a)1    		   14 (7.08 cM)5
    697211  NM_023526.31  NP_076015.21 
     182711365 
    chicken
    (Gallus gallus)    		 Aves NKIRAS11 NFKB inhibitor interacting Ras-like 1 76.01(n)
    78.34(a)    		   420654  XM_418753.3  XP_418753.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NKIRAS16
    		 Uncharacterized protein
    		 73(a)
    		 1 ↔ 1
    		 GL343357.1(669718-682964)
    zebrafish
    (Danio rerio)    		 Actinopterygii nkiras11 NFKB inhibitor interacting Ras-like 1 68.24(n)
    73.3(a)    		   100002175  NM_001100076.1  NP_001093546.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG305031 CG30503 51.31(n)
    43.82(a)    		   246656  NM_001144141.2  NP_001137613.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_F52A8.61 Protein F52A8.6 49.73(n)
    43.85(a)    		   172487  NM_059675.5  NP_492076.1 


    ENSEMBL Gene Tree for NKIRAS1 (if available)
    TreeFam Gene Tree for NKIRAS1 (if available)

    Paralogs
    for NKIRAS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKIRAS1 gene
    NKIRAS22  
    14 SIMAP similar genes for NKIRAS1 using alignment to 2 protein entries:     KBRS1_HUMAN (see all proteins):
    NKIRAS2    RAB7B    RHEBL1    DKFZp547A0616    RAP1B    KRAS
    RAP2A    RAP2B    NRAS    RALB    RAP2C    c-bas/has
    RRAS2    HRAS

    NKIRAS1 for paralogs           About GeneDecksing



    Genomic Variants
    for NKIRAS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/518 SNPs in NKIRAS1 are shown (see all 518)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs589055551,2
    		C--23881400(+) AAAAA-/A/AA  
                TGCAG     		1 -- int11NA 2
    rs14691,2
    		C,F,H--23933804(+) TATGAC/ATAGTT 1 -- ut315Minor allele frequency- A:0.00MN NS EA 604
    rs1429561111,2
    		--23933835(+) AGATAC/GAGTCT 1 -- ut310--------
    rs89331,2
    		C,F,A,H--23933969(-) ATCACG/TCTCTA 1 -- ut3129Minor allele frequency- T:0.16MN NA NS EA WA CSA 3180
    rs67899831,2
    		C,F,A,H--23934115(+) TGTTTT/GGGGTC 1 -- ut3122Minor allele frequency- G:0.13NA NS EA WA 2470
    rs1507040231,2
    		C--23934122(+) GGTCCA/TATTTA 1 -- ut310--------
    rs1925319711,2
    		--23934132(+) AGACAC/TAAAAA 1 -- ut310--------
    rs799687701,2
    		C--23934225(+) ACACAG/TAATGA 1 -- ut310--------
    rs348690951,2
    		C,F--23934277(-) CACCTA/GTGTGT 1 -- ut313Minor allele frequency- G:0.03NS WA 206
    rs1494651241,2
    		C--23934322(+) TCACAA/CGTACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NKIRAS1 (23933151 - 23988082 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NKIRAS1: --
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKIRAS1
    DNA2.0 Custom Variant and Variant Library Synthesis for NKIRAS1

    Disorders / Diseases
    for NKIRAS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NKIRAS1 for disorders           About GeneDecksing

    OMIM gene information: 604496    OMIM disorders: --

    4 diseases for NKIRAS1:    About MalaCards
    renal cell carcinoma    rheumatoid arthritis    arthritis    lung cancer

    Genetic Association Database (GAD): NKIRAS1
    Human Genome Epidemiology (HuGE) Navigator: NKIRAS1 (2 documents)

    Export disorders for NKIRAS1 gene to outside databases

    Publications
    for NKIRAS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKIRAS1 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with NKIRAS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)1, 2, 3, 9 Fenwick C....Ghosh S. (2000)
    2. Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4, 9 Dieguez-Gonzalez R....Gonzalez A. (2008)
    3. Genetic and epigenetic changes of NKIRAS1 gene in hum an renal cell carcinomas. (PubMed id 20693965)1, 4 Gerashchenko G.V....Kashuba V.I. (2010)
    4. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PubMed id 15024091)1, 2 Chen Y.... Ghosh G. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes. (PubMed id 12672800)1, 2 Chen Y.... Ghosh G. (2003)
    8. Prognostic significance of kappaB-Ras1 expression in g liomas. (PubMed id 21302000)1 Lin H....Cheng J. (2012)
    9. [Methylation of some miRNA genes is involved in the re gulation of their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]. (PubMed id 23156677)1 Khodyrev D.S....Braga E.A. (2012)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    External Searches for NKIRAS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NKIRAS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28512 HGNC: 17899 AceView: NKIRAS1 Ensembl:ENSG00000197885 euGenes: HUgn28512
    ECgene: NKIRAS1 H-InvDB: NKIRAS1

    Other Databases showing NKIRAS1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NKIRAS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKIRAS1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NKIRAS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NKIRAS1 gene:
    Search GeneIP for patents involving NKIRAS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NKIRAS1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NKIRAS1   OriGene RNAi products in human, mouse, rat for NKIRAS1  
     OriGene qPCR primer pairs and template standards for NKIRAS1   OriGene Protein Over-expression Lysate for NKIRAS1  
     OriGene MassSpec something-or-other for NKIRAS1   OriGene clones in human, mouse for NKIRAS1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NKIRAS1   OriGene Purified Protein for NKIRAS1  
     OriGene ORF clones in mouse, rat for NKIRAS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NKIRAS1   OriGene Custom Protein Services for NKIRAS1  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NKIRAS1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKIRAS1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKIRAS1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKIRAS1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKIRAS1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKIRAS1
     GenScript Custom Purified and Recombinant Proteins Services for NKIRAS1 GenScript cDNA clones with any tag delivered in your preferred vector for NKIRAS1
     GenScript Custom Assay Services for NKIRAS1 GenScript Custom Superior Antibodies Services for NKIRAS1
     GenScript Custom overexpressing Cell Line Services for NKIRAS1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NKIRAS1 promoter
     Search Chromatin IP Primers for NKIRAS1
     RT2 qPCR Primer Assay in human, mouse, rat NKIRAS1
     Search GNC Networks for NKIRAS1
     SABiosciences Custom PCR Arrays for NKIRAS1
     Search Tocris compounds for NKIRAS1 (KBRS1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NKIRAS1 antibodies
     NKIRAS1 proteins
     NKIRAS1 lysates
     Antibodies for NKIRAS1
     See all of Abcam's Antibodies, Kits and Proteins for NKIRAS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NKIRAS1




     Proteins for NKIRAS1
     Antibodies for NKIRAS1
     ELISAs for NKIRAS1
     CLIAs for NKIRAS1
     Search LifeMap BioReagents cell lines for NKIRAS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKIRAS1
     SwitchGear 3'UTR luciferase reporter plasmids for NKIRAS1
     SwitchGear Promoter luciferase reporter plasmids for NKIRAS1
     ThermoFisher Antibodies for NKIRAS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKIRAS1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NKIRAS1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NKIRAS1
    Customized:
     stable knockdown cell line services for NKIRAS1
     inducible knockdown cell line services for NKIRAS1
     design and validation of potent shRNA sequences against NKIRAS1
     adenovirus for potent knockdown of NKIRAS1
     stable overexpressing cell line services for NKIRAS1
     inducible overexpressing cell line services for NKIRAS1
     adenovirus for overexpression of NKIRAS1
     LSBio Antibodies in human, mouse, rat for NKIRAS1
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NKIRAS1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4