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NKIRAS1 Gene

protein-coding   GIFtS: 50
GCID: GC03M023933

NFKB Inhibitor Interacting Ras-Like 1

(Previous name: NFKB inhibitor interacting Ras-like protein 1)
  See related diseases
at
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Aliases
for NKIRAS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NFKB Inhibitor Interacting Ras-Like 11 2     Kappa B-Ras 12
NFKB Inhibitor Interacting Ras-Like Protein 11 2     kappaB-Ras12
Kappa B-Ras Protein 12 3     NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 12
KBRAS12 3     KappaB-Ras13
I-Kappa-B-Interacting Ras-Like Protein 12 3     

External Ids:    HGNC: 178991   Entrez Gene: 285122   Ensembl: ENSG000001978857   OMIM: 6044965   UniProtKB: Q9NYS03   

Export aliases for NKIRAS1 gene to outside databases

Previous GC identifers: GC03M023908 GC03M023879


Summaries
for NKIRAS1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NKIRAS1 Gene:
NKIRAS1 (NFKB inhibitor interacting Ras-like 1) is a protein-coding gene. Diseases associated with NKIRAS1 include renal cell carcinoma, and rheumatoid arthritis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS2.

UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA
NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block
phosphorylation of NFKBIB




Genomic Views
for NKIRAS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKIRAS1 gene promoter:
         AML1a   NRSF form 1   NRSF form 2   NF-kappaB   C/EBPalpha   FOXJ2 (long isoform)   FOXJ2   Msx-1   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKIRAS1 promoter sequence
   Search Chromatin IP Primers for NKIRAS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKIRAS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.2   HGNC cytogenetic band: 3p24.1

NKIRAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKIRAS1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M023933:  view genomic region     (about GC identifiers)

Start:
 23,933,151 bp from pter      End:
 23,988,082 bp from pter
Size:
 54,932 bases      Orientation:
 minus strand

Proteins
for NKIRAS1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor-interacting Ras-like protein 1  
Size: 192 amino acids; 21643 Da
Subunit: Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably
only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and
p65/RELA). Also interacts with c-Rel (REL)
Secondary accessions: Q96K18

Explore the universe of human proteins at neXtProt for NKIRAS1: NX_Q9NYS0

Explore proteomics data for NKIRAS1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See NKIRAS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065078.1  
    ENSEMBL proteins: 
     ENSP00000373411   ENSP00000393785   ENSP00000392307   ENSP00000400385   ENSP00000406543  
     ENSP00000396063   ENSP00000415225   ENSP00000394214  

    NKIRAS1 Human Recombinant Protein Products:

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    Novus Biologicals NKIRAS1 Proteins
    Novus Biologicals NKIRAS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NKIRAS1
    Cloud-Clone Corp. Proteins for NKIRAS1

    NKIRAS1 Antibody Products:

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    ThermoFisher Antibodies for NKIRAS1
    LSBio Antibodies in human, mouse, rat for NKIRAS1

    NKIRAS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for NKIRAS1
    Cloud-Clone Corp. CLIAs for NKIRAS1

    Domains /
    Families
    for NKIRAS1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    TryGeneCards Plus    		 4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9NYS0

    ProtoNet protein and cluster: Q9NYS0

    UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
    Domain: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the
    conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore
    similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family
    are clearly different from other small GTPases proteins
    Similarity: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily


    NKIRAS1 for domains           About GeneDecksing


    Function
    for NKIRAS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KBRS1_HUMAN, Q9NYS0
    Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the
    degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to
    degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA
    NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block
    phosphorylation of NFKBIB

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10657303
    GO:0005525GTP binding IEA--
         
    NKIRAS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nkiras1):
     no phenotypic analysis 

    NKIRAS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nkiras1tm1Brs for NKIRAS1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKIRAS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NKIRAS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKIRAS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NKIRAS1

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat NKIRAS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NKIRAS1 (see all 14):
    hsa-miR-607 hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-4272 hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: NKIRAS1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for NKIRAS1
    Predesigned siRNA for gene silencing in human, mouse, rat NKIRAS1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NKIRAS1

    Clone
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    OriGene ORF clones in mouse, rat for NKIRAS1
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    GenScript: all cDNA clones in your preferred vector: NKIRAS1 (NM_020345)
    Sino Biological Human cDNA Clone for NKIRAS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKIRAS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKIRAS1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NKIRAS1 
    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKIRAS1


    Localization
    for NKIRAS1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KBRS1_HUMAN, Q9NYS0: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    NKIRAS1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for NKIRAS1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NKIRAS1 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    		TNF-alpha/NF-kB Signaling Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NKIRAS1
        NF-KappaB Family Pathway

    1 BioSystems Pathway for NKIRAS1
        TNF-alpha/NF-kB Signaling Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKIRAS1
    Interactions:

        Search GeneGlobe Interaction Network for NKIRAS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NKIRAS1 (Q9NYS03 ENSP000003734114) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    NFKBIBQ156533, ENSP000003129884I2D: score=3 STRING: ENSP00000312988
    NFKBIAP259633, ENSP000002167974I2D: score=2 STRING: ENSP00000216797
    BMPR1BO002383, ENSP000002645684I2D: score=3 STRING: ENSP00000264568
    SMURF2Q9HAU43, ENSP000002624354I2D: score=2 STRING: ENSP00000262435
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007249I-kappaB kinase/NF-kappaB signaling NAS10657303
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    NKIRAS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NKIRAS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NKIRAS1 (KBRS1)

    1 HMDB Compound for NKIRAS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    Transcripts
    for NKIRAS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NKIRAS1 gene: 
    NM_020345.3  

    Unigene Cluster for NKIRAS1:

    NFKB inhibitor interacting Ras-like 1
    Hs.173202  [show with all ESTs]
    Unigene Representative Sequence: NM_020345
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388759 ENST00000443659 ENST00000421515(uc003cck.3) ENST00000425478(uc003ccj.3)
    ENST00000437230 ENST00000412028 ENST00000415901 ENST00000416026
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat NKIRAS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NKIRAS1 (see all 14):
    hsa-miR-607 hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-4272 hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: NKIRAS1 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for NKIRAS1
    Predesigned siRNA for gene silencing in human, mouse, rat NKIRAS1
    Clone
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NKIRAS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NKIRAS1
      QuantiTect SYBR Green Assays in human, mouse, rat NKIRAS1
      QuantiFast Probe-based Assays in human, mouse, rat NKIRAS1

    Additional mRNA sequence: 

    AF229839.1 AK027749.1 BC012145.1 BC066940.1 BC150589.1 

    7 DOTS entries:

    DT.100811879  DT.100811882  DT.120901956  DT.97822718  DT.100811880  DT.102839491  DT.120902089 

    Selected AceView cDNA sequences (see all 93):

    AA010714 N79148 AW002634 CR602142 AA551591 CR600782 AI302092 CA429686 
    AA458628 AA370473 AA010575 BE504686 AI470823 AI187968 CR606911 CA426818 
    AF229839 NM_020345 BC012145 BM696013 BG108552 AI659135 AI659150 BP347329 

    GeneLoc Exon Structure


    Expression
    for NKIRAS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NKIRAS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGAGGTA
    NKIRAS1 Expression
    About this image

    NKIRAS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    NKIRAS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.173202

    UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0
    Tissue specificity: Widely expressed

        Custom PCR Arrays for NKIRAS1
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    In Situ
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKIRAS1

    Orthologs
    for NKIRAS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NKIRAS1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nkiras11 , 5 NFKB inhibitor interacting Ras-like protein 11, 5 86.81(n)1
    95.31(a)1    		   14 (7.08 cM)5
    697211  NM_023526.31  NP_076015.21 
     182711365 
    chicken
    (Gallus gallus)    		 Aves NKIRAS11 NFKB inhibitor interacting Ras-like 1 77.49(n)
    79.06(a)    		   420654  XM_004939403.1  XP_004939460.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NKIRAS16
    		 NFKB inhibitor interacting Ras-like 1
    		 73(a)
    		 1 ↔ 1
    		 GL343357.1(669718-682964)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia nkiras11 NFKB inhibitor interacting Ras-like 1 72.92(n)
    76.56(a)    		   100489722  XM_002932411.2  XP_002932457.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii nkiras11 NFKB inhibitor interacting Ras-like 1 68.24(n)
    73.3(a)    		   100002175  NM_001100076.1  NP_001093546.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta kappaB-Ras1 kappaB-Ras 51.31(n)
    43.82(a)    		   35667  NM_136434.5  NP_610278.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_F52A8.61 CELE_F52A8.6 49.73(n)
    43.85(a)    		   172487  NM_001047203.2  NP_001040668.1 


    ENSEMBL Gene Tree for NKIRAS1 (if available)
    TreeFam Gene Tree for NKIRAS1 (if available)

    Paralogs
    for NKIRAS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NKIRAS1 gene
    NKIRAS22  
    14 SIMAP similar genes for NKIRAS1 using alignment to 2 protein entries:     KBRS1_HUMAN (see all proteins):
    NKIRAS2    RAB7B    RHEBL1    DKFZp547A0616    RAP1B    KRAS
    RAP2A    RAP2B    NRAS    RALB    RAP2C    c-bas/has
    RRAS2    HRAS

    NKIRAS1 for paralogs           About GeneDecksing



    Genomic Variants
    for NKIRAS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for NKIRAS1 (see all 518)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs589055551,2
    		C--23881400(+) AAAAA-/A/AA  
                TGCAG     		1 -- int11NA 2
    rs14691,2
    		C,F,H--23933804(+) TATGAC/ATAGTT 1 -- ut315Minor allele frequency- A:0.00MN NS EA 604
    rs1429561111,2
    		--23933835(+) AGATAC/GAGTCT 1 -- ut310--------
    rs89331,2
    		C,F,A,H--23933969(-) ATCACG/TCTCTA 1 -- ut3129Minor allele frequency- T:0.16MN NA NS EA WA CSA 3180
    rs67899831,2
    		C,F,A,H--23934115(+) TGTTTT/GGGGTC 1 -- ut3122Minor allele frequency- G:0.13NA NS EA WA 2470
    rs1507040231,2
    		C--23934122(+) GGTCCA/TATTTA 1 -- ut310--------
    rs1925319711,2
    		--23934132(+) AGACAC/TAAAAA 1 -- ut310--------
    rs799687701,2
    		C--23934225(+) ACACAG/TAATGA 1 -- ut310--------
    rs348690951,2
    		C,F--23934277(-) CACCTA/GTGTGT 1 -- ut313Minor allele frequency- G:0.03NS WA 206
    rs1494651241,2
    		C--23934322(+) TCACAA/CGTACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NKIRAS1 (23933151 - 23988082 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NKIRAS1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NKIRAS1
    DNA2.0 Custom Variant and Variant Library Synthesis for NKIRAS1

    Disorders / Diseases
    for NKIRAS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604496    OMIM disorders: --

    5 diseases for NKIRAS1:    
    About MalaCards
    renal cell carcinoma    rheumatoid arthritis    arthritis    lung cancer
    malaria


    NKIRAS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NKIRAS1
    Human Genome Epidemiology (HuGE) Navigator: NKIRAS1 (2 documents)

    Export disorders for NKIRAS1 gene to outside databases

    Publications
    for NKIRAS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKIRAS1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with NKIRAS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)1, 2, 3, 9 Fenwick C....Ghosh S. (Science 2000)
    2. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4, 9 Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
    3. Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas. (PubMed id 20693965)1, 4 Gerashchenko G.V....Kashuba V.I. (Exp. Oncol. 2010)
    4. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PubMed id 15024091)1, 2 Chen Y.... Ghosh G. (Mol. Cell. Biol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes. (PubMed id 12672800)1, 2 Chen Y.... Ghosh G. (J. Biol. Chem. 2003)
    8. Prognostic significance of kappaB-Ras1 expression in gliomas. (PubMed id 21302000)1 Lin H....Cheng J. (Med. Oncol. 2012)
    9. [Methylation of some miRNA genes is involved in the regulation of their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]. (PubMed id 23156677)1 Khodyrev D.S....Braga A.8.A. (Mol. Biol. (Mosk.) 2012)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    External Searches for NKIRAS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
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    Genome Databases showing NKIRAS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 28512 HGNC: 17899 AceView: NKIRAS1 Ensembl:ENSG00000197885 euGenes: HUgn28512
    ECgene: NKIRAS1 H-InvDB: NKIRAS1

    Other Databases showing NKIRAS1 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing NKIRAS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NKIRAS1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NKIRAS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for NKIRAS1 gene:
    Search GeneIP for patents involving NKIRAS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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