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NKIRAS1 Gene

protein-coding GIFtS: 50
GCID: GC03M023933

NFKB Inhibitor Interacting Ras-Like 1

(Previous name: NFKB inhibitor interacting Ras-like protein 1)

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MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
NFKB Inhibitor Interacting Ras-Like 1¹ ²		Kappa B-Ras 1²
NFKB Inhibitor Interacting Ras-Like Protein 1¹ ²		kappaB-Ras1²
Kappa B-Ras Protein 1² ³		NF-Kappa-B Inhibitor-Interacting Ras-Like Protein 1²
KBRAS1² ³		KappaB-Ras1³
I-Kappa-B-Interacting Ras-Like Protein 1² ³

External Ids:	HGNC: 17899¹	Entrez Gene: 28512²	Ensembl: ENSG00000197885⁷	OMIM: 604496⁵	UniProtKB: Q9NYS0³

Export aliases for NKIRAS1 gene to outside databases

Previous GC identifers: GC03M023908 GC03M023879

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NKIRAS1 Gene:

NKIRAS1 (NFKB inhibitor interacting Ras-like 1) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS2.

UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0

Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the

degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to

degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA

NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block

phosphorylation of NFKBIB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000003.11 NT_022517.19 NC_018914.2

Regulatory elements:

Regulatory transcription factor binding sites in the NKIRAS1 gene promoter:
AML1a NRSF form 1 NRSF form 2 NF-kappaB C/EBPalpha FOXJ2 (long isoform) FOXJ2 Msx-1 NF-kappaB1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKIRAS1 promoter sequence

Search Chromatin IP Primers for NKIRAS1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKIRAS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2 Ensembl cytogenetic band: 3p24.2 HGNC cytogenetic band: 3p24.1

NKIRAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKIRAS1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M023933: view genomic region (about GC identifiers)

Start:	23,933,151 bp from pter	End:	23,988,082 bp from pter
Size:	54,932 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0 (See protein sequence)

Recommended Name: NF-kappa-B inhibitor-interacting Ras-like protein 1

Size: 192 amino acids; 21643 Da

Subunit: Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably

only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and

p65/RELA). Also interacts with c-Rel (REL)

Secondary accessions: Q96K18

Explore the universe of human proteins at neXtProt for NKIRAS1: NX_Q9NYS0

Explore proteomics data for NKIRAS1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See NKIRAS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_065078.1

ENSEMBL proteins:

ENSP00000373411 ENSP00000393785 ENSP00000392307 ENSP00000400385 ENSP00000406543

ENSP00000396063 ENSP00000415225 ENSP00000394214

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	antibodies-online peptides for NKIRAS1

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro protein domains:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR027417 P-loop_NTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry Q9NYS0

ProtoNet protein and cluster: Q9NYS0

UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0

Domain: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the

conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore

similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family

are clearly different from other small GTPases proteins

Similarity: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily

Find genes that share domains with NKIRAS1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KBRS1_HUMAN, Q9NYS0

Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the

degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to

degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA

NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block

phosphorylation of NFKBIB

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	NAS	10657303
GO:0005525	GTP binding	IEA	--

Find genes that share ontologies with NKIRAS1 About GenesLikeMe

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nkiras1):

no phenotypic analysis

Find genes that share phenotypes with NKIRAS1 About GenesLikeMe

Animal Models:
MGI mouse knock-out Nkiras1^tm1Brs for NKIRAS1

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

KBRS1_HUMAN, Q9NYS0: Cytoplasm

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
extracellular	1
lysosome	1
mitochondrion	1
nucleus	1
plasma membrane	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IEA	--
GO:0016020	membrane	IEA	--

Find genes that share ontologies with NKIRAS1 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

SuperPaths for NKIRAS1 About

See pathways by source

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SuperPath

Contained pathways About

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NKIRAS1

NF-KappaB Family Pathway

1 BioSystems Pathway for NKIRAS1

TNF-alpha/NF-kB Signaling Pathway

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for NKIRAS1
Interactions:

Search GeneGlobe Interaction Network for NKIRAS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for NKIRAS1 (Q9NYS0³ ENSP00000373411⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACVR1	Q04771³, ENSP00000263640⁴	I2D: score=3 STRING: ENSP00000263640
NFKBIB	Q15653³, ENSP00000312988⁴	I2D: score=3 STRING: ENSP00000312988
NFKBIA	P25963³, ENSP00000216797⁴	I2D: score=2 STRING: ENSP00000216797
BMPR1B	O00238³, ENSP00000264568⁴	I2D: score=3 STRING: ENSP00000264568
SMURF2	Q9HAU4³, ENSP00000262435⁴	I2D: score=2 STRING: ENSP00000262435

About this table

Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	--	--
GO:0007165	signal transduction	--	--
GO:0007249	I-kappaB kinase/NF-kappaB signaling	NAS	10657303
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0015031	protein transport	--	--

Find genes that share ontologies with NKIRAS1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for NKIRAS1 (KBRS1)

1 HMDB Compound for NKIRAS1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for NKIRAS1 gene:

NM_020345.3

Unigene Cluster for NKIRAS1:

NFKB inhibitor interacting Ras-like 1

Hs.173202 [show with all ESTs]

Unigene Representative Sequence: NM_020345

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000388759 ENST00000443659 ENST00000421515(uc003cck.3) ENST00000425478(uc003ccj.3)

ENST00000437230 ENST00000412028 ENST00000415901 ENST00000416026

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Additional mRNA sequence:

AF229839.1 AK027749.1 BC012145.1 BC066940.1 BC150589.1

7 DOTS entries:

DT.100811879 DT.100811882 DT.120901956 DT.97822718 DT.100811880 DT.102839491 DT.120902089

Selected AceView cDNA sequences (see all 93):

AA010714 N79148 AW002634 CR602142 AA551591 CR600782 AI302092 CA429686

AA458628 AA370473 AA010575 BE504686 AI470823 AI187968 CR606911 CA426818

AF229839 NM_020345 BC012145 BM696013 BG108552 AI659135 AI659150 BP347329

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NKIRAS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGTTGAGGTA

About this image

NKIRAS1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NKIRAS1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.173202

UniProtKB/Swiss-Prot: KBRS1_HUMAN, Q9NYS0

Tissue specificity: Widely expressed

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NKIRAS1 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nkiras1^{1 , 5}	NFKB inhibitor interacting Ras-like protein 1^{1, 5}	86.81(n)¹ 95.31(a)¹		14 (7.08 cM)⁵ 69721¹ NM_023526.3¹ NP_076015.2¹ 18271136⁵
chicken (Gallus gallus)	Aves	NKIRAS1¹	NFKB inhibitor interacting Ras-like 1	77.49(n) 79.06(a)		420654 XM_004939403.1 XP_004939460.1
lizard (Anolis carolinensis)	Reptilia	NKIRAS1⁶	NFKB inhibitor interacting Ras-like 1	73(a)	1 ↔ 1	GL343357.1(669718-682964)
tropical clawed frog (Xenopus tropicalis)	Amphibia	nkiras1¹	NFKB inhibitor interacting Ras-like 1	72.92(n) 76.56(a)		100489722 XM_002932411.2 XP_002932457.2
zebrafish (Danio rerio)	Actinopterygii	nkiras1¹	NFKB inhibitor interacting Ras-like 1	68.24(n) 73.3(a)		100002175 NM_001100076.1 NP_001093546.1
fruit fly (Drosophila melanogaster)	Insecta	kappaB-Ras¹	kappaB-Ras	51.31(n) 43.82(a)		35667 NM_136434.5 NP_610278.1
worm (Caenorhabditis elegans)	Secernentea	CELE_F52A8.6¹	CELE_F52A8.6	49.73(n) 43.85(a)		172487 NM_001047203.2 NP_001040668.1

ENSEMBL Gene Tree for NKIRAS1 (if available)
TreeFam Gene Tree for NKIRAS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NKIRAS1 gene

NKIRAS2²

14 SIMAP similar genes for NKIRAS1 using alignment to 2 protein entries: KBRS1_HUMAN (see all proteins):

NKIRAS2 RAB7B RHEBL1 DKFZp547A0616 RAP1B KRAS

RAP2A RAP2B NRAS RALB RAP2C c-bas/has

RRAS2 HRAS

Find genes that share paralogs with NKIRAS1 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58905555^1,2	C	--	23881400(+)	`AAAAA-/A/AA TGCAG`	1	--	int¹		1		NA	2
rs1469^1,2	C,F,H	--	23933804(+)	`TATGAC/ATAGTT`	1	--	ut3¹		5		MN NS EA	604
rs142956111^1,2		--	23933835(+)	`AGATAC/GAGTCT`	1	--	ut3¹		0	--	--	--	--
rs8933^1,2	C,F,A,H	--	23933969(-)	`ATCACG/TCTCTA`	1	--	ut3¹		29		MN NA NS EA WA CSA	3180
rs6789983^1,2	C,F,A,H	--	23934115(+)	`TGTTTT/GGGGTC`	1	--	ut3¹		22		NA NS EA WA	2470
rs150704023^1,2	C	--	23934122(+)	`GGTCCA/TATTTA`	1	--	ut3¹		0	--	--	--	--
rs192531971^1,2		--	23934132(+)	`AGACAC/TAAAAA`	1	--	ut3¹		0	--	--	--	--
rs79968770^1,2	C	--	23934225(+)	`ACACAG/TAATGA`	1	--	ut3¹		0	--	--	--	--
rs34869095^1,2	C,F	--	23934277(-)	`CACCTA/GTGTGT`	1	--	ut3¹		3		NS WA	206
rs149465124^1,2	C	--	23934322(+)	`TCACAA/CGTACA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NKIRAS1 (23933151 - 23988082 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for NKIRAS1: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NKIRAS1

DNA2.0 Custom Variant and Variant Library Synthesis for NKIRAS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 604496 OMIM disorders: --

Find genes that share disorders with NKIRAS1 About GenesLikeMe

Genetic Association Database (GAD): NKIRAS1
Human Genome Epidemiology (HuGE) Navigator: NKIRAS1 (2 documents)

Export disorders for NKIRAS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NKIRAS1 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with NKIRAS1)

Utopia: connect your pdf to the dynamic
world of online information

A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)^{1, 2, 3, 9} Fenwick C....Ghosh S. (Science 2000)
Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)^{1, 4, 9} Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas. (PubMed id 20693965)^{1, 4} Gerashchenko G.V....Kashuba V.I. (Exp. Oncol. 2010)
Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PubMed id 15024091)^{1, 2} Chen Y.... Ghosh G. (Mol. Cell. Biol. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes. (PubMed id 12672800)^{1, 2} Chen Y.... Ghosh G. (J. Biol. Chem. 2003)
Prognostic significance of kappaB-Ras1 expression in gliomas. (PubMed id 21302000)¹ Lin H....Cheng J. (Med. Oncol. 2012)
[Methylation of some miRNA genes is involved in the regulation of their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]. (PubMed id 23156677)¹ Khodyrev D.S....Braga A.8.A. (Mol. Biol. (Mosk.) 2012)
Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (Mol. Syst. Biol. 2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 28512	HGNC: 17899	AceView: NKIRAS1	Ensembl:ENSG00000197885	euGenes: HUgn28512
ECgene: NKIRAS1	H-InvDB: NKIRAS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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PharmGKB entry for NKIRAS1	Pharmacogenomics, SNPs, Pathways

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NFKB Inhibitor Interacting Ras-Like 1

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