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NKIRAS1 Gene(Protein Coding)

NFKB Inhibitor Interacting Ras-Like 1

GCID:
GC03M023891
GIFtS:
51
Genes Participants
UDN Logo

Aliases for NKIRAS1 Gene

Aliases for NKIRAS1 Gene

  • NFKB Inhibitor Interacting Ras-Like 1 2 3 5
  • NFKB Inhibitor Interacting Ras-Like Protein 1 2 3
  • I-Kappa-B-Interacting Ras-Like Protein 1 3 4
  • Kappa B-Ras Protein 1 3 4
  • KappaB-Ras1 3 4
  • KBRAS1 3 4
  • Kappa B-Ras 1 3

External Ids for NKIRAS1 Gene

Previous GeneCards Identifiers for NKIRAS1 Gene

  • GC03M023908
  • GC03M023933
  • GC03M023879

Summaries for NKIRAS1 Gene

GeneCards Summary for NKIRAS1 Gene

NKIRAS1 (NFKB Inhibitor Interacting Ras-Like 1) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS2.

UniProtKB/Swiss-Prot for NKIRAS1 Gene

  • Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKIRAS1 Gene

Genomics for NKIRAS1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for NKIRAS1 Gene

Enhancers for NKIRAS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NKIRAS1 on UCSC Golden Path with GeneCards custom track

Promoters for NKIRAS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NKIRAS1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NKIRAS1 gene promoter:

Genomic Location for NKIRAS1 Gene

Chromosome:
3
Start:
23,891,660 bp from pter
End:
23,946,591 bp from pter
Size:
54,932 bases
Orientation:
Minus strand

Genomic View for NKIRAS1 Gene

Genes around NKIRAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKIRAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKIRAS1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NKIRAS1 Gene

Proteins for NKIRAS1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NKIRAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYS0-KBRS1_HUMAN
    Recommended name:
    NF-kappa-B inhibitor-interacting Ras-like protein 1
    Protein Accession:
    Q9NYS0
    Secondary Accessions:
    • Q96K18

    Protein attributes for NKIRAS1 Gene

    Size:
    192 amino acids
    Molecular mass:
    21643 Da
    Quaternary structure:
    • Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also interacts with c-Rel (REL).

neXtProt entry for NKIRAS1 Gene

Proteomics data for NKIRAS1 Gene at MOPED

Protein Expression for NKIRAS1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NKIRAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKIRAS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKIRAS1 Gene

Domains & Families for NKIRAS1 Gene

Gene Families for NKIRAS1 Gene

HGNC:

Protein Domains for NKIRAS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKIRAS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYS0

UniProtKB/Swiss-Prot:

KBRS1_HUMAN :
  • In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
Domain:
  • In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
Family:
  • Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
genes like me logo Genes that share domains with NKIRAS1: view

Function for NKIRAS1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for NKIRAS1 Gene

UniProtKB/Swiss-Prot Function:
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

Phenotypes for NKIRAS1 Gene

MGI mutant phenotypes for NKIRAS1:
inferred from 1 alleles
GenomeRNAi human phenotypes for NKIRAS1:
genes like me logo Genes that share phenotypes with NKIRAS1: view

Animal Models for NKIRAS1 Gene

MGI Knock Outs for NKIRAS1:

Animal Model Products

miRNA for NKIRAS1 Gene

miRTarBase miRNAs that target NKIRAS1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKIRAS1 Gene

Localization for NKIRAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKIRAS1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKIRAS1 Gene COMPARTMENTS Subcellular localization image for NKIRAS1 gene
Compartment Confidence
cytosol 2
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NKIRAS1 Gene

Pathways & Interactions for NKIRAS1 Gene

genes like me logo Genes that share pathways with NKIRAS1: view

Pathways by source for NKIRAS1 Gene

1 BioSystems pathway for NKIRAS1 Gene
1 Qiagen pathway for NKIRAS1 Gene

Gene Ontology (GO) - Biological Process for NKIRAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with NKIRAS1: view

No data available for SIGNOR curated interactions for NKIRAS1 Gene

Drugs & Compounds for NKIRAS1 Gene

Products:

  1. Drug

(1) Drugs for NKIRAS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with NKIRAS1: view

Transcripts for NKIRAS1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for NKIRAS1 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(93) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKIRAS1 Gene

NFKB inhibitor interacting Ras-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKIRAS1 Gene

No ASD Table

Relevant External Links for NKIRAS1 Gene

GeneLoc Exon Structure for
NKIRAS1
ECgene alternative splicing isoforms for
NKIRAS1

Expression for NKIRAS1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for NKIRAS1 Gene

mRNA expression in normal human tissues for NKIRAS1 Gene
mRNA expression by BioGPS for NKIRAS1 GenemRNA expression by GTEx for NKIRAS1 Gene

Protein differential expression in normal tissues from HIPED for NKIRAS1 Gene

This gene is overexpressed in Bone (18.2), Retina (17.7), and Frontal cortex (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NKIRAS1 Gene



SOURCE GeneReport for Unigene cluster for NKIRAS1 Gene Hs.173202

mRNA Expression by UniProt/SwissProt for NKIRAS1 Gene

Q9NYS0-KBRS1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NKIRAS1: view

Protein tissue co-expression partners for NKIRAS1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NKIRAS1 Gene

Orthologs for NKIRAS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKIRAS1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia NKIRAS1 35
  • 92.36 (n)
  • 98.44 (a)
NKIRAS1 36
  • 98 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Nkiras1 35
  • 86.81 (n)
  • 95.31 (a)
Nkiras1 16
Nkiras1 36
  • 95 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia NKIRAS1 35
  • 99.83 (n)
  • 100 (a)
NKIRAS1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Nkiras1 35
  • 83.85 (n)
  • 96.35 (a)
cow
(Bos Taurus)
 Mammalia NKIRAS1 36
  • 88 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NKIRAS1 36
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia NKIRAS1 36
  • 52 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NKIRAS1 35
  • 77.49 (n)
  • 79.06 (a)
NKIRAS1 36
  • 79 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NKIRAS1 36
  • 73 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia nkiras1 35
  • 72.92 (n)
  • 76.56 (a)
zebrafish
(Danio rerio)
 Actinopterygii nkiras1 35
  • 68.24 (n)
  • 73.3 (a)
nkiras1 36
  • 73 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP011283 35
  • 51.25 (n)
  • 46.24 (a)
fruit fly
(Drosophila melanogaster)
 Insecta kappaB-Ras 35
  • 51.31 (n)
  • 43.82 (a)
kappaB-Ras 36
  • 39 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea CELE_F52A8.6 35
  • 49.73 (n)
  • 43.85 (a)
F52A8.6 36
  • 22 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 48 (a)
 OneToMany
Species with no ortholog for NKIRAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKIRAS1 Gene

ENSEMBL:
Gene Tree for NKIRAS1 (if available)
TreeFam:
Gene Tree for NKIRAS1 (if available)

Paralogs for NKIRAS1 Gene

Paralogs for NKIRAS1 Gene

(14) SIMAP similar genes for NKIRAS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NKIRAS1: view

Variants for NKIRAS1 Gene

Sequence variations from dbSNP and Humsavar for NKIRAS1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1469 -- 23,892,313(+) TATGA(A/C)TAGTT utr-variant-3-prime
rs8933 -- 23,892,478(-) ATCAC(G/T)CTCTA utr-variant-3-prime
rs1136155 -- 23,892,999(-) TTTGT(A/G)TCTAC utr-variant-3-prime
rs6550809 -- 23,897,209(+) taggg(A/G)aaaaa intron-variant
rs9815334 -- 23,904,095(+) aggat(A/G)cggag intron-variant

Variation tolerance for NKIRAS1 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NKIRAS1 Gene

Disorders for NKIRAS1 Gene

Relevant External Links for NKIRAS1

Genetic Association Database (GAD)
NKIRAS1
Human Genome Epidemiology (HuGE) Navigator
NKIRAS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKIRAS1

No disorders were found for NKIRAS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKIRAS1 Gene

Publications for NKIRAS1 Gene

  1. A subclass of Ras proteins that regulate the degradation of IkappaB. (PMID: 10657303) Fenwick C. … Ghosh S. (Science 2000) 2 3 4 23 67
  2. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 23
  3. Upregulation of RHOA and NKIRAS1 genes in lung tumors is associated with loss of their methylation as well as with methylation of regulatory miRNA genes. (PMID: 25869366) Braga E.A. … Kushlinskii N.E. (Biochemistry Mosc. 2015) 3
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  5. Prognostic significance of kappaB-Ras1 expression in gliomas. (PMID: 21302000) Lin H. … Cheng J. (Med. Oncol. 2012) 3

Products for NKIRAS1 Gene

Sources for NKIRAS1 Gene

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