Aliases for NKIRAS1 Gene
Aliases for NKIRAS1 Gene
External Ids for NKIRAS1 Gene
- HGNC: 17899
- Entrez Gene: 28512
- Ensembl: ENSG00000197885
- OMIM: 604496
- UniProtKB: Q9NYS0
Previous GeneCards Identifiers for NKIRAS1 Gene
- GC03M023908
- GC03M023933
- GC03M023879
Summaries for NKIRAS1 Gene
GeneCards Summary for NKIRAS1 Gene
NKIRAS1 (NFKB Inhibitor Interacting Ras Like 1) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS2.
UniProtKB/Swiss-Prot for NKIRAS1 Gene
-
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKIRAS1 Gene
Genomics for NKIRAS1 Gene
Regulatory Elements for NKIRAS1 Gene
Enhancers for NKIRAS1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03G023915 | 1.2 | ENCODE | 13.1 | +29.4 | 29377 | 4.1 | MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 | NKIRAS1 NR1D2 RPL15 |
| GH03G023873 | 1.3 | Ensembl ENCODE | 11.5 | +72.1 | 72061 | 1.1 | HDGF PKNOX1 ATF1 ARNT FEZF1 ZNF48 ZNF2 YY1 FOS SP3 | RPL15 NKIRAS1 NR1D2 ARL4AP4 GC03M023860 |
| GH03G023864 | 1.2 | Ensembl ENCODE | 11.7 | +80.8 | 80805 | 2.1 | ATF1 TCF12 ZNF766 GATA2 JUNB TBX21 MEF2D SMARCA4 GLIS1 MYNN | RPL15 NKIRAS1 UBE2E1 UBE2E1-AS1 NR1D2 GC03M023860 ARL4AP4 |
| GH03G023829 | 1.1 | Ensembl ENCODE | 11.4 | +116.7 | 116743 | 1.1 | PKNOX1 TBL1XR1 BMI1 ZNF121 CBX5 RELB ETV6 IKZF2 CREM ZNF202 | UBE2E1-AS1 UBE2E1 NKIRAS1 NR1D2 RPL15 GC03P023841 |
| GH03G023991 | 1.1 | Ensembl ENCODE | 11.2 | -45.5 | -45470 | 1.8 | INSM2 FEZF1 RAD21 ZEB1 GATA2 ZNF366 ZSCAN5C SCRT2 FOS ELK4 | NKIRAS1 RPL15 NPM1P23 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around NKIRAS1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the NKIRAS1 gene promoter:
Regulatory Element Products
Genomic Location for NKIRAS1 Gene
- Chromosome:
- 3
- Start:
- 23,891,660 bp from pter
- End:
- 23,946,591 bp from pter
- Size:
- 54,932 bases
- Orientation:
- Minus strand
Genomic View for NKIRAS1 Gene
Genes around NKIRAS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p24.2 by Ensembl
- 3p24.2 by Entrez Gene
- 3p24.2 by HGNC
NKIRAS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NKIRAS1 Gene
Proteins for NKIRAS1 Gene
-
Protein details for NKIRAS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYS0-KBRS1_HUMAN
- Recommended name:
- NF-kappa-B inhibitor-interacting Ras-like protein 1
- Protein Accession:
- Q9NYS0
- Q96K18
Protein attributes for NKIRAS1 Gene
- Size:
- 192 amino acids
- Molecular mass:
- 21643 Da
- Quaternary structure:
-
- Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also interacts with c-Rel (REL).
Protein Expression for NKIRAS1 Gene
Post-translational modifications for NKIRAS1 Gene
Other Protein References for NKIRAS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- antibodies-online Antibodies for NKIRAS1: See all 60
- GeneTex NKIRAS1 antibody for NKIRAS1
-
Custom Antibody ServicesProSci Antibodies for NKIRAS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for NKIRAS1
Protein Products
-
OriGene Purified Proteins for NKIRAS1
- Search Origene for MassSpec and Protein Over-expression Lysates for NKIRAS1
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- antibodies-online Proteins for NKIRAS1: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NKIRAS1
No data available for DME Specific Peptides for NKIRAS1 Gene
Domains & Families for NKIRAS1 Gene
Gene Families for NKIRAS1 Gene
Protein Domains for NKIRAS1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NKIRAS1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NYS0UniProtKB/Swiss-Prot:
KBRS1_HUMAN :- In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
- Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
- Domain:
-
- In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
- Family:
-
- Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
Function for NKIRAS1 Gene
Molecular function for NKIRAS1 Gene
- UniProtKB/Swiss-Prot Function:
- Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | NAS | 10657303 |
| GO:0005525 | GTP binding | IEA | -- |
Phenotypes for NKIRAS1 Gene
- MGI mutant phenotypes for NKIRAS1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NKIRAS1:
Animal Models for NKIRAS1 Gene
- MGI Knock Outs for NKIRAS1:
-
- Nkiras1 tm1Brs
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
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-
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CRISPR Products
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-
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miRNA for NKIRAS1 Gene
- miRTarBase miRNAs that target NKIRAS1
-
- hsa-mir-6505-3p (MIRT571853)
- hsa-mir-617 (MIRT571854)
- hsa-mir-4509 (MIRT571855)
- hsa-mir-4744 (MIRT571856)
- hsa-mir-519c-3p (MIRT571857)
- hsa-mir-519b-3p (MIRT571858)
- hsa-mir-519a-3p (MIRT571859)
- hsa-mir-4796-3p (MIRT571860)
- hsa-mir-3609 (MIRT571861)
- hsa-mir-548ah-5p (MIRT571862)
- hsa-mir-20a-5p (MIRT571863)
- hsa-mir-106b-5p (MIRT571864)
- hsa-mir-20b-5p (MIRT571865)
- hsa-mir-519d-3p (MIRT571866)
- hsa-mir-93-5p (MIRT571867)
- hsa-mir-526b-3p (MIRT571868)
- hsa-mir-17-5p (MIRT571869)
- hsa-mir-106a-5p (MIRT571870)
miRNA Products
- Search ViGene Biosciences for NKIRAS1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for NKIRAS1
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Clone Products
-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for NKIRAS1
-
ViGene Biosciences adenoviral particle packaged cDNA for NKIRAS1 gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKIRAS1 Gene
Localization for NKIRAS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NKIRAS1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for NKIRAS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | NF-KappaB Family Pathway | ||
Pathways by source for NKIRAS1 Gene
1 Qiagen pathway for NKIRAS1 Gene
Interacting Proteins for NKIRAS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | NAS | 10657303 |
| GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
No data available for SIGNOR curated interactions for NKIRAS1 Gene
Drugs & Compounds for NKIRAS1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for NKIRAS1 Gene
mRNA/cDNA for NKIRAS1 Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (93) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NKIRAS1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NKIRAS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NKIRAS1
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for NKIRAS1
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-
ViGene Biosciences ready-to-package AAV shRNAs for NKIRAS1 gene
Clone Products
-
OriGene ORF clones in human for NKIRAS1
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NKIRAS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NKIRAS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for NKIRAS1 Gene
This gene is overexpressed in Bone (18.2), Retina (17.7), and Frontal cortex (16.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NKIRAS1 Gene
NURSA nuclear receptor signaling pathways regulating expression of NKIRAS1 Gene:
NKIRAS1SOURCE GeneReport for Unigene cluster for NKIRAS1 Gene:
Hs.173202mRNA Expression by UniProt/SwissProt for NKIRAS1 Gene:
Q9NYS0-KBRS1_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for NKIRAS1 Gene
- Nervous system(4.7)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for NKIRAS1
-
OriGene qPCR primer pairs and template standards for NKIRAS1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKIRAS1 Gene
Orthologs for NKIRAS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NKIRAS1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | NKIRAS1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | NKIRAS1 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Nkiras1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nkiras1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NKIRAS1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NKIRAS1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NKIRAS1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NKIRAS1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nkiras1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nkiras1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | kappaB-Ras 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011283 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F52A8.6 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for NKIRAS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NKIRAS1 Gene
Variants for NKIRAS1 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005534 | -- | 23,912,837(+) | ACATA(C/T)GTCGG | intron-variant | |
| rs1000011300 | -- | 23,897,598(+) | ACTGC(C/T)GATTC | intron-variant | |
| rs1000161174 | -- | 23,910,047(+) | AGAGA(C/T)GGGGT | intron-variant | |
| rs1000387932 | -- | 23,916,005(+) | TTTCC(C/T)GCTGC | intron-variant, upstream-variant-2KB | |
| rs1000436754 | -- | 23,916,207(+) | ACATC(C/T)GAACG | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1005186 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.36;
7.93% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NKIRAS1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NKIRAS1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKIRAS1 Gene
Disorders for NKIRAS1 Gene
Relevant External Links for NKIRAS1
No disorders were found for NKIRAS1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKIRAS1 Gene
Publications for NKIRAS1 Gene
- A subclass of Ras proteins that regulate the degradation of IkappaB. (PMID: 10657303) Fenwick C. … Ghosh S. (Science 2000) 2 3 4 22 64
- Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 22 46 64
- Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas. (PMID: 20693965) Gerashchenko G.V. … Kashuba V.I. (Exp. Oncol. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for NKIRAS1 Gene
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- VectorBuilder custom plasmid, inducible vectors for NKIRAS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NKIRAS1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for NKIRAS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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