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Aliases for NKG7 Gene

Aliases for NKG7 Gene

  • Natural Killer Cell Granule Protein 7 2 3
  • Natural Killer Cell Group 7 Sequence 2 3
  • Granule Membrane Protein Of 17 KDa 3 4
  • Natural Killer Cell Protein 7 3 4
  • G-CSF-Induced Gene 1 Protein 3 4
  • Granule Membrane Protein 17 2 3
  • GIG-1 Protein 3 4
  • P15-TIA-1 3 4
  • GMP-17 3 4
  • GIG1 3 4
  • Protein NKG7 3

External Ids for NKG7 Gene

Previous GeneCards Identifiers for NKG7 Gene

  • GC19M052505
  • GC19M052236
  • GC19M056550
  • GC19M056566
  • GC19M051874
  • GC19M048206

Summaries for NKG7 Gene

GeneCards Summary for NKG7 Gene

NKG7 (Natural Killer Cell Granule Protein 7) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKG7 Gene

Genomics for NKG7 Gene

Regulatory Elements for NKG7 Gene

Genomic Location for NKG7 Gene

Start:
51,371,606 bp from pter
End:
51,372,722 bp from pter
Size:
1,117 bases
Orientation:
Minus strand

Genomic View for NKG7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKG7 Gene

Proteins for NKG7 Gene

  • Protein details for NKG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16617-NKG7_HUMAN
    Recommended name:
    Protein NKG7
    Protein Accession:
    Q16617
    Secondary Accessions:

    Protein attributes for NKG7 Gene

    Size:
    165 amino acids
    Molecular mass:
    17665 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKG7 Gene

Proteomics data for NKG7 Gene at MOPED

Post-translational modifications for NKG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKG7 Gene

No data available for DME Specific Peptides for NKG7 Gene

Domains for NKG7 Gene

Protein Domains for NKG7 Gene

Suggested Antigen Peptide Sequences for NKG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16617

UniProtKB/Swiss-Prot:

NKG7_HUMAN :
  • Q16617
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with NKG7: view

No data available for Gene Families for NKG7 Gene

Function for NKG7 Gene

Molecular function for NKG7 Gene

GENATLAS Biochemistry: natural killer,group 7 sequence
UniProtKB/Swiss-Prot Induction: By CSF3/G-CSF

Gene Ontology (GO) - Molecular Function for NKG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NKG7: view

Phenotypes for NKG7 Gene

GenomeRNAi human phenotypes for NKG7:
genes like me logo Genes that share phenotypes with NKG7: view

Animal Model Products

CRISPR Products

miRNA for NKG7 Gene

miRTarBase miRNAs that target NKG7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NKG7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NKG7 Gene

Localization for NKG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKG7 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic granule membrane; Multi-pass membrane protein. Note=Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKG7 Gene COMPARTMENTS Subcellular localization image for NKG7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for NKG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8458737
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NKG7: view

Pathways for NKG7 Gene

SuperPathways for NKG7 Gene

No Data Available

Interacting Proteins for NKG7 Gene

Gene Ontology (GO) - Biological Process for NKG7 Gene

None

No data available for Pathways by source for NKG7 Gene

Transcripts for NKG7 Gene

Unigene Clusters for NKG7 Gene

Natural killer cell group 7 sequence:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NKG7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKG7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3: - -

Relevant External Links for NKG7 Gene

GeneLoc Exon Structure for
NKG7
ECgene alternative splicing isoforms for
NKG7

Expression for NKG7 Gene

mRNA expression in normal human tissues for NKG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKG7 Gene

This gene is overexpressed in Whole Blood (44.3).

SOURCE GeneReport for Unigene cluster for NKG7 Gene Hs.10306

mRNA Expression by UniProt/SwissProt for NKG7 Gene

Q16617-NKG7_HUMAN
Tissue specificity: Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells
genes like me logo Genes that share expressions with NKG7: view

In Situ Assay Products

No data available for Protein expression for NKG7 Gene

Orthologs for NKG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NKG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKG7 35
  • 97.88 (n)
  • 94.44 (a)
NKG7 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKG7 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKG7 35
  • 77.78 (n)
  • 64.24 (a)
NKG7 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkg7 35
  • 75.35 (n)
  • 69.7 (a)
Nkg7 16
Nkg7 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKG7 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkg7 35
  • 76.57 (n)
  • 71.52 (a)
lizard
(Anolis carolinensis)
Reptilia NKG7 36
  • 35 (a)
OneToOne
Species with no ortholog for NKG7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NKG7 Gene

ENSEMBL:
Gene Tree for NKG7 (if available)
TreeFam:
Gene Tree for NKG7 (if available)

Paralogs for NKG7 Gene

No data available for Paralogs for NKG7 Gene

Variants for NKG7 Gene

Sequence variations from dbSNP and Humsavar for NKG7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3009 -- 51,371,696(-) GGTCC(C/T)ACATC utr-variant-3-prime
rs4257 -- 51,371,721(-) CTCAT(A/C)TGGAG utr-variant-3-prime
rs1044351 -- 51,372,521(-) TGCCG(A/G)TCCCT synonymous-codon, reference
rs1044359 -- 51,371,992(-) TTCTT(C/T)TCCTG reference, synonymous-codon
rs2241387 -- 51,372,326(+) GACCA(C/T)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKG7 Gene

Variant ID Type Subtype PubMed ID
nsv912294 CNV Gain 21882294

Relevant External Links for NKG7 Gene

HapMap Linkage Disequilibrium report
NKG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKG7 Gene

Disorders for NKG7 Gene

(1) Novoseek inferred disease relationships for NKG7 Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia chronic 54.1 1
genes like me logo Genes that share disorders with NKG7: view

No data available for UniProtKB/Swiss-Prot for NKG7 Gene

Publications for NKG7 Gene

  1. Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells. (PMID: 8458737) Turman M.A. … Houchins J.P. (Hum. Immunol. 1993) 2 3 4 23
  2. Molecular cloning and characterization of G-CSF induced gene cDNA. (PMID: 7510105) Shimane M. … Asano S. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition. (PMID: 8570616) Medley Q.G. … Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 1996) 4 23
  5. Significant expression of G-CSF-induced gene-1 (GIG-1) protein in myeloid cells and NK cells. (PMID: 9886253) Shimane M. … Asano S. (J. Leukoc. Biol. 1999) 23

Products for NKG7 Gene

Sources for NKG7 Gene

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