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Aliases for NKG7 Gene

Aliases for NKG7 Gene

  • Natural Killer Cell Granule Protein 7 2 3 5
  • Natural Killer Cell Group 7 Sequence 2 3
  • Granule Membrane Protein Of 17 KDa 3 4
  • Natural Killer Cell Protein 7 3 4
  • G-CSF-Induced Gene 1 Protein 3 4
  • Granule Membrane Protein 17 2 3
  • GIG-1 Protein 3 4
  • P15-TIA-1 3 4
  • GMP-17 3 4
  • GIG1 3 4
  • Protein NKG7 3

External Ids for NKG7 Gene

Previous GeneCards Identifiers for NKG7 Gene

  • GC19M052505
  • GC19M052236
  • GC19M056550
  • GC19M056566
  • GC19M051874
  • GC19M048206

Summaries for NKG7 Gene

GeneCards Summary for NKG7 Gene

NKG7 (Natural Killer Cell Granule Protein 7) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKG7 Gene

Genomics for NKG7 Gene

Regulatory Elements for NKG7 Gene

Enhancers for NKG7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051338 1.1 ENCODE 12.1 +32.9 32943 2.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF416 ZNF143 POLD1 ZNF616 ZNF766 CLDND2 ETFB NKG7 ZNF841 ZNF836 SIGLEC8 CEACAM18
GH19G051406 1.1 Ensembl ENCODE 11.9 -35.5 -35539 2.9 ATF1 RAD21 GATA2 ZNF143 FOS RCOR1 SMARCA5 MIER2 REST SREBF1 CLDND2 NKG7 ETFB SIGLEC8 VSIG10L RPL7P51 SIGLEC14 SIGLEC5 FPR3 SIGLEC10
GH19G051326 1.1 Ensembl ENCODE 11.4 +45.5 45485 1.9 HDAC1 TBP ATF1 CBX3 RB1 AGO1 ARID4B ZBTB40 ZNF48 RAD21 ETFB CLDND2 NKG7 SIGLEC8 CEACAM18 SIGLEC14 SIGLEC5 RPL7P51 ENSG00000267905 GC19M051338
GH19G051438 0.6 ENCODE 10.8 -65.7 -65684 0.1 CTCF PKNOX1 TEAD4 TRIM22 MIER2 REST RAD21 IKZF1 SMC3 SIGLEC12 CEACAM18 VSIG10L SIGLEC14 SIGLEC5 RPL7P51 CLDND2 NKG7 ETFB MIR125A
GH19G051349 1 ENCODE 5.5 +21.3 21332 3.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A DMAP1 YY1 ZNF766 FOS VSIG10L SIGLEC8 RPL7P51 SIGLEC14 SIGLEC5 IGLON5 NKG7 ENSG00000267984 ENSG00000268520
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NKG7 on UCSC Golden Path with GeneCards custom track

Genomic Location for NKG7 Gene

Chromosome:
19
Start:
51,371,606 bp from pter
End:
51,372,728 bp from pter
Size:
1,123 bases
Orientation:
Minus strand

Genomic View for NKG7 Gene

Genes around NKG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKG7 Gene

Proteins for NKG7 Gene

  • Protein details for NKG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16617-NKG7_HUMAN
    Recommended name:
    Protein NKG7
    Protein Accession:
    Q16617

    Protein attributes for NKG7 Gene

    Size:
    165 amino acids
    Molecular mass:
    17665 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKG7 Gene

Post-translational modifications for NKG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKG7 Gene

No data available for DME Specific Peptides for NKG7 Gene

Domains & Families for NKG7 Gene

Protein Domains for NKG7 Gene

Suggested Antigen Peptide Sequences for NKG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16617

UniProtKB/Swiss-Prot:

NKG7_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family.
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with NKG7: view

No data available for Gene Families for NKG7 Gene

Function for NKG7 Gene

Molecular function for NKG7 Gene

GENATLAS Biochemistry:
natural killer,group 7 sequence
UniProtKB/Swiss-Prot Induction:
By CSF3/G-CSF.

Gene Ontology (GO) - Molecular Function for NKG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NKG7: view
genes like me logo Genes that share phenotypes with NKG7: view

Animal Model Products

CRISPR Products

miRNA for NKG7 Gene

miRTarBase miRNAs that target NKG7

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKG7 Gene

Localization for NKG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKG7 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic granule membrane; Multi-pass membrane protein. Note=Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKG7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for NKG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 8458737
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NKG7: view

Pathways & Interactions for NKG7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKG7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NKG7 Gene

Drugs & Compounds for NKG7 Gene

No Compound Related Data Available

Transcripts for NKG7 Gene

Unigene Clusters for NKG7 Gene

Natural killer cell group 7 sequence:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKG7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3: - -

Relevant External Links for NKG7 Gene

GeneLoc Exon Structure for
NKG7
ECgene alternative splicing isoforms for
NKG7

Expression for NKG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKG7 Gene

This gene is overexpressed in Whole Blood (x44.3).

NURSA nuclear receptor signaling pathways regulating expression of NKG7 Gene:

NKG7

SOURCE GeneReport for Unigene cluster for NKG7 Gene:

Hs.10306

mRNA Expression by UniProt/SwissProt for NKG7 Gene:

Q16617-NKG7_HUMAN
Tissue specificity: Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.

Evidence on tissue expression from TISSUES for NKG7 Gene

  • Blood(4.6)
  • Bone marrow(2.3)
genes like me logo Genes that share expression patterns with NKG7: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKG7 Gene

Orthologs for NKG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NKG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKG7 34 35
  • 97.88 (n)
dog
(Canis familiaris)
Mammalia NKG7 34 35
  • 77.78 (n)
rat
(Rattus norvegicus)
Mammalia Nkg7 34
  • 76.57 (n)
mouse
(Mus musculus)
Mammalia Nkg7 34 16 35
  • 75.35 (n)
cow
(Bos Taurus)
Mammalia NKG7 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKG7 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKG7 35
  • 35 (a)
OneToOne
Species where no ortholog for NKG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NKG7 Gene

ENSEMBL:
Gene Tree for NKG7 (if available)
TreeFam:
Gene Tree for NKG7 (if available)

Paralogs for NKG7 Gene

No data available for Paralogs for NKG7 Gene

Variants for NKG7 Gene

Sequence variations from dbSNP and Humsavar for NKG7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000741364 -- 51,374,694(+) CCCTA(C/T)CCCCA upstream-variant-2KB
rs1001031573 -- 51,372,594(+) ACTCT(A/T)GAATC utr-variant-5-prime
rs1002087622 -- 51,373,001(+) CAGGC(G/T)AGGGT upstream-variant-2KB
rs1003396070 -- 51,373,789(+) CTTCT(C/T)CCTGC upstream-variant-2KB
rs1003613465 -- 51,373,413(+) GGCCT(-/A)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NKG7 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for NKG7 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKG7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKG7 Gene

Disorders for NKG7 Gene

Relevant External Links for NKG7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKG7

No disorders were found for NKG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKG7 Gene

Publications for NKG7 Gene

  1. Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells. (PMID: 8458737) Turman M.A. … Houchins J.P. (Hum. Immunol. 1993) 2 3 4 22 64
  2. Molecular cloning and characterization of G-CSF induced gene cDNA. (PMID: 7510105) Shimane M. … Asano S. (Biochem. Biophys. Res. Commun. 1994) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition. (PMID: 8570616) Medley Q.G. … Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 1996) 4 22 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for NKG7 Gene

Sources for NKG7 Gene

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