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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKG7 Gene

protein-coding   GIFtS: 48
GCID: GC19M051874

natural killer cell group 7 sequence
 Explore 3 diseases affiliated with
NKG7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NKG7    

Aliases
for NKG7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Natural Killer Cell Group 7 Sequence1 2     G-CSF-Induced Gene 1 Protein2 3
GIG11 2 3     GIG-1 Protein2 3
Granule Membrane Protein Of 17 KDa2 3     P15-TIA-11
Natural Killer Cell Protein 72 3     Protein NKG72
GMP-172 3     

External Ids:    HGNC: 78301   Entrez Gene: 48182   Ensembl: ENSG000001053747   OMIM: 6060085   UniProtKB: Q166173   
ORGUL members:         
NONCODE:n338909    

Export aliases for NKG7 gene to outside databases

Previous GC identifers: GC19M052505 GC19M052236 GC19M056550 GC19M056566 GC19M048206


Summaries
for NKG7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for NKG7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKG7 gene promoter:
         Pax-5   Pax-6   RelA   NF-kappaB   HNF-4alpha1   Roaz   GATA-1   CP2   HSF2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKG7 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKG7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKG7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

NKG7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKG7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051874:  view genomic region     (about GC identifiers)

Start:
 51,874,874 bp from pter      End:
 51,875,960 bp from pter
Size:
 1,087 bases      Orientation:
 minus strand

Proteins
for NKG7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NKG7_HUMAN, Q16617 (See protein sequence)
Recommended Name: Protein NKG7  
Size: 165 amino acids; 17665 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic granule membrane; Multi-pass membrane
protein. Note=Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils

Explore the universe of human proteins at neXtProt for NKG7: NX_Q16617

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16617

    • NKG7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005592.1  
    ENSEMBL proteins: 
     ENSP00000221978  

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    Uscn Proteins for NKG7

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS8458737


    NKG7 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NKG7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NKG7 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004032 PMP22_EMP_MP20
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry Q16617

    ProtoNet protein and cluster: Q16617

    UniProtKB/Swiss-Prot: NKG7_HUMAN, Q16617
    Similarity: Belongs to the PMP-22/EMP/MP20 family


    Function
    for NKG7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NKG7_HUMAN, Q16617
    Induction: By CSF3/G-CSF

         Genatlas biochemistry entry for NKG7:
    natural killer,group 7 sequence

    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    1 GenomeRNAi human phenotype for NKG7:
     Decreased cell number, increas 


    Pathways & Interactions
    for NKG7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKG7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NKG7 (ENSP000002219784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GORABENSP000003567374STRING: ENSP00000356737
    About this table

    Drugs & Compounds
    for NKG7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKG7
    Search CenterWatch for drugs/clinical trials and news about NKG7 

    Transcripts
    for NKG7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NKG7 gene: 
    NM_005601.3  

    Unigene Cluster for NKG7:

    Natural killer cell group 7 sequence
    Hs.10306  [show with all ESTs]
    Unigene Representative Sequence: BM918012
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000221978(uc002pwj.3 uc002pwk.3)

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    hsa-miR-3185
    SwitchGear 3'UTR luciferase reporter plasmid: NKG7 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC015759.1 S69115.1 

    3 DOTS entries:

    DT.209928  DT.91693064  DT.95172256 

    24/115 AceView cDNA sequences (see all 115):

    NM_005601 CB216430 BC074917 BF726389 BC069430 BI521219 BM696265 AF340019 
    BU734982 BF726953 BM699967 BU735198 BM669926 BM705518 BQ054295 BM705781 
    BQ051624 BC074916 BM564372 BF726767 BF727069 BQ052927 BM696344 BQ053800 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NKG7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                                                
    SP2:                    -                           
    SP3:                    -     -                     


    ECgene alternative splicing isoforms for NKG7

    Expression
    for NKG7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKG7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGTGGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NKG7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NKG7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKG7

    SOURCE GeneReport for Unigene cluster: Hs.10306

    UniProtKB/Swiss-Prot: NKG7_HUMAN, Q16617
    Tissue specificity: Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart,
    or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha
    beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones
    and in cell lines representing B-cells, monocytes, and myeloid cells

        SABiosciences Custom PCR Arrays for NKG7
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NKG7

    Orthologs
    for NKG7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NKG7 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nkg71 , 5 natural killer cell group 7 sequence1, 5 75.35(n)1
    69.7(a)1    		   7 (28.25 cM)5
    723101  NM_024253.41  NP_077215.21 
     434371385 
    lizard
    (Anolis carolinensis)    		 Reptilia NKG76
    		 --
    		 34(a)
    		 1 ↔ 1
    		 GL343281.1(1110940-1113838)


    ENSEMBL Gene Tree for NKG7 (if available)
    TreeFam Gene Tree for NKG7 (if available) 

    Paralogs
    for NKG7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NKG7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/114 NCBI SNPs in NKG7 are shown (see all 114)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1173645301,2
    		--51874603(+) CTGGCA/TAGGGG 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs677671121,2
    		C,--51874652(+) GCTAAA/TGGGAG 1 -- ds50013Minor allele frequency- T:0.05WA NA 240
    rs50260351,2
    		C,F,H,--51874741(+) GCACTC/TGTACT 1 -- ds500121Minor allele frequency- T:0.19NS EA NA WA 2754
    rs1479196731,2
    		--51874813(+) CTCCTA/GCCATG 1 -- ds50010--------
    rs1875370461,2
    		--51874814(+) TCCTAC/TCATGG 1 -- ds50010--------
    rs1408003031,2
    		--51874899(+) ATGAAC/TGAAGA 1 -- ut310--------
    rs30091,2
    		C,F,A,H,--51874950(-) GGTCCT/CACATC 1 -- ut31 ese332Minor allele frequency- C:0.27EA MN NS NA WA CSA 7549
    rs611285931,2
    		C,F,--51874965(+) TTTCCC/TGAGGC 1 -- ut315Minor allele frequency- T:0.10WA CSA EA 244
    rs42571,2
    		F--51874975(-) CTCATA/CTGGAG 1 -- ut313Minor allele frequency- C:0.34EA MN 4644
    rs1501111941,2
    		C,--51874998(+) CAACGA/CTCAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NKG7 (51874874 - 51875960 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NKG7: --

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    Disorders / Diseases
    for NKG7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NKG7 for disorders           About GeneDecksing

    OMIM gene information: 606008    OMIM disorders: --

    3 diseases for NKG7:    About MalaCards
    gilles de la tourette syndrome    tourette syndrome    sezary's disease

    1 disease from the University of Copenhagen DISEASES database for NKG7:
    Gilles de la Tourette syndrome

    1 Novoseek disease relationship for NKG7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 54.1 1 9886253 (1)


    Export disorders for NKG7 gene to outside databases

    Publications
    for NKG7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKG7 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NKG7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells. (PubMed id 8458737)1, 2, 3, 9 Turman M.A.... Houchins J.P. (1993)
    2. Molecular cloning and characterization of G-CSF induced gene cDNA. (PubMed id 7510105)1, 2, 9 Shimane M.... Asano S. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition. (PubMed id 8570616)2, 9 Medley Q.G.... Anderson P. (1996)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Significant expression of G-CSF-induced gene-1 (GIG-1) protein in myeloid cells and NK cells. (PubMed id 9886253)9 Shimane M....Asano S. (1999)

    External Searches for NKG7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NKG7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4818 HGNC: 7830 AceView: NKG7andLIM2 Ensembl:ENSG00000105374 euGenes: HUgn4818
    ECgene: NKG7 H-InvDB: NKG7

    Other Databases showing NKG7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NKG7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKG7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NKG7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NKG7 gene:
    Search GeneIP for patents involving NKG7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NKG7 gene

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    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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