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Aliases for NKD2 Gene

Aliases for NKD2 Gene

  • Naked Cuticle Homolog 2 2 3 5
  • Dvl-Binding Protein NKD2 2 3
  • Naked Cuticle Homolog 2 (Drosophila) 2
  • Protein Naked Cuticle Homolog 2 3
  • Naked Cuticle-2 2
  • Naked-2 4
  • Naked2 3
  • HNkd2 4

External Ids for NKD2 Gene

Previous GeneCards Identifiers for NKD2 Gene

  • GC05P001220
  • GC05M001180
  • GC05P001041
  • GC05P001061
  • GC05P001062
  • GC05P001008

Summaries for NKD2 Gene

Entrez Gene Summary for NKD2 Gene

  • This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for NKD2 Gene

NKD2 (Naked Cuticle Homolog 2) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Wnt / Hedgehog / Notch. GO annotations related to this gene include calcium ion binding and growth factor binding. An important paralog of this gene is NKD1.

UniProtKB/Swiss-Prot for NKD2 Gene

  • Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKD2 Gene

Genomics for NKD2 Gene

Regulatory Elements for NKD2 Gene

Enhancers for NKD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F000955 1.6 FANTOM5 Ensembl ENCODE 12.9 -51.2 -51182 3.6 PKNOX1 SIN3A ZNF48 YY1 FOS MCM3 NFYC JUNB ZNF592 MXD3 NKD2 ENSG00000248949 LOC100506688 ENSG00000248994 GC05P000958 GC05P000950
GH05F000931 0.4 ENCODE 11.7 -77.7 -77740 0.2 CTBP1 KLF1 ZEB2 RCOR1 KLF4 ENSG00000250173 LOC100506688 NKD2 TRIP13 BRD9 CTD-3080P12.3 SLC6A3 PIR31047 GC05P000914
GH05F001020 0.9 FANTOM5 ENCODE 9.8 +12.5 12524 1.9 ZBTB8A MNT ZIC2 ZFHX2 SCRT2 ZNF341 TCF7 ZNF600 EGR2 TCF7L2 NKD2 SLC12A7 ENSG00000272347 SLC6A18 GC05P001049
GH05F001067 1.3 FANTOM5 ENCODE 7.4 +59.0 59041 0.4 ATF1 ARNT CREB3L1 ZNF766 ELK1 GATA2 NCOA1 CREB3 MEF2D MBD2 NKD2 ZDHHC11 MIR4635 GC05M001107
GH05F001004 0.2 ENCODE 7 -4.3 -4253 1.2 ATF1 CREB3L1 ZNF493 SIN3A GLI4 ZNF48 ZNF121 GLIS2 KLF7 ZNF263 LOC728613 LOC100506688 ENSG00000271119 ENSG00000248949 NKD2 ENSG00000272347 GTF2H2C_2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NKD2 on UCSC Golden Path with GeneCards custom track

Promoters for NKD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001866583 180 801 CTCF SIN3A ZNF335 ZFHX2 GLIS2 POLR2A EGR1 SCRT2 PATZ1 ZNF143

Genomic Location for NKD2 Gene

Chromosome:
5
Start:
1,008,820 bp from pter
End:
1,038,943 bp from pter
Size:
30,124 bases
Orientation:
Plus strand

Genomic View for NKD2 Gene

Genes around NKD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKD2 Gene

Proteins for NKD2 Gene

  • Protein details for NKD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969F2-NKD2_HUMAN
    Recommended name:
    Protein naked cuticle homolog 2
    Protein Accession:
    Q969F2
    Secondary Accessions:
    • Q96EK8
    • Q9BSN0

    Protein attributes for NKD2 Gene

    Size:
    451 amino acids
    Molecular mass:
    50055 Da
    Quaternary structure:
    • Interacts with DVL1, DVL2, DVL3 and PPP2R3A (By similarity). Interacts with RNF25 and TGFA (via cytoplasmic domain).

    Alternative splice isoforms for NKD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKD2 Gene

Post-translational modifications for NKD2 Gene

  • Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKD2 Gene

No data available for DME Specific Peptides for NKD2 Gene

Domains & Families for NKD2 Gene

Gene Families for NKD2 Gene

Protein Domains for NKD2 Gene

Suggested Antigen Peptide Sequences for NKD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969F2

UniProtKB/Swiss-Prot:

NKD2_HUMAN :
  • The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured.
  • Belongs to the NKD family.
Domain:
  • The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured.
  • Contains 1 EF-hand domain.
Family:
  • Belongs to the NKD family.
genes like me logo Genes that share domains with NKD2: view

Function for NKD2 Gene

Molecular function for NKD2 Gene

UniProtKB/Swiss-Prot Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.

Gene Ontology (GO) - Molecular Function for NKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15687260
GO:0019838 growth factor binding IPI 15064403
GO:0031625 ubiquitin protein ligase binding IPI 18757723
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NKD2: view
genes like me logo Genes that share phenotypes with NKD2: view

Animal Models for NKD2 Gene

MGI Knock Outs for NKD2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKD2 Gene

Localization for NKD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKD2 Gene

Cell membrane. Cytoplasm. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKD2 Gene COMPARTMENTS Subcellular localization image for NKD2 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016323 basolateral plasma membrane IDA 17553928
GO:0016328 colocalizes_with lateral plasma membrane IDA 20177058
genes like me logo Genes that share ontologies with NKD2: view

Pathways & Interactions for NKD2 Gene

genes like me logo Genes that share pathways with NKD2: view

Pathways by source for NKD2 Gene

2 GeneTex pathways for NKD2 Gene
1 Cell Signaling Technology pathway for NKD2 Gene
1 KEGG pathway for NKD2 Gene

Gene Ontology (GO) - Biological Process for NKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis IEA --
GO:0010954 positive regulation of protein processing IDA 15064403
GO:0016055 Wnt signaling pathway IEA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 20177058
genes like me logo Genes that share ontologies with NKD2: view

No data available for SIGNOR curated interactions for NKD2 Gene

Transcripts for NKD2 Gene

Unigene Clusters for NKD2 Gene

Naked cuticle homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKD2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for NKD2 Gene

GeneLoc Exon Structure for
NKD2
ECgene alternative splicing isoforms for
NKD2

Expression for NKD2 Gene

mRNA expression in normal human tissues for NKD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKD2 Gene

This gene is overexpressed in Lung (x9.7) and Spleen (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of NKD2 Gene:

NKD2

SOURCE GeneReport for Unigene cluster for NKD2 Gene:

Hs.240951

mRNA Expression by UniProt/SwissProt for NKD2 Gene:

Q969F2-NKD2_HUMAN
Tissue specificity: Expressed in kidney, lung, pancreas and spleen.
genes like me logo Genes that share expression patterns with NKD2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NKD2 Gene

Orthologs for NKD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKD2 34 35
  • 95.25 (n)
rat
(Rattus norvegicus)
Mammalia Nkd2 34
  • 79.67 (n)
dog
(Canis familiaris)
Mammalia NKD2 34 35
  • 79.55 (n)
mouse
(Mus musculus)
Mammalia Nkd2 34 16 35
  • 78.89 (n)
cow
(Bos Taurus)
Mammalia NKD2 34 35
  • 78.43 (n)
oppossum
(Monodelphis domestica)
Mammalia NKD2 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKD2 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nkd2b 34
  • 55.15 (n)
nkd2a 35
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nkd 35
  • 11 (a)
OneToMany
Species where no ortholog for NKD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKD2 Gene

ENSEMBL:
Gene Tree for NKD2 (if available)
TreeFam:
Gene Tree for NKD2 (if available)

Paralogs for NKD2 Gene

Paralogs for NKD2 Gene

(1) SIMAP similar genes for NKD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NKD2: view

Variants for NKD2 Gene

Sequence variations from dbSNP and Humsavar for NKD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035330 -- 1,029,584(+) AAACA(C/T)GGCAC intron-variant
rs10037180 -- 1,027,358(+) AGCTG(C/T)GCCTT intron-variant
rs10038951 -- 1,039,257(+) GGAGA(C/T)GGTTG downstream-variant-500B
rs10040050 -- 1,027,036(+) TGGTG(A/G)CAATG intron-variant
rs10040052 -- 1,027,039(+) TGACA(A/G)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKD2 Gene

Variant ID Type Subtype PubMed ID
dgv1065e214 CNV loss 21293372
dgv686n27 CNV loss 19166990
dgv9518n54 CNV loss 21841781
dgv9519n54 CNV gain 21841781
dgv9520n54 CNV gain+loss 21841781
dgv9521n54 CNV loss 21841781
dgv9522n54 CNV loss 21841781
esv1007931 CNV deletion 20482838
esv2669088 CNV deletion 23128226
esv2674300 CNV deletion 23128226
esv2729379 CNV deletion 23290073
esv2729380 CNV deletion 23290073
esv2729381 CNV deletion 23290073
esv2729382 CNV deletion 23290073
esv2741210 CNV deletion 23290073
esv27512 CNV gain+loss 19812545
esv2759316 CNV gain+loss 17122850
esv3603788 CNV loss 21293372
esv3603789 CNV gain 21293372
esv3603792 CNV gain 21293372
esv3603794 CNV loss 21293372
esv3894109 CNV gain 25118596
esv3894110 CNV loss 25118596
esv990038 CNV deletion 20482838
esv999700 CNV gain 20482838
nsv10654 CNV gain+loss 18304495
nsv1074794 CNV deletion 25765185
nsv1133013 OTHER inversion 24896259
nsv1135951 CNV deletion 24896259
nsv1147234 OTHER inversion 26484159
nsv329395 CNV deletion 16902084
nsv428459 CNV gain+loss 18775914
nsv461896 CNV loss 19166990
nsv469577 CNV loss 16826518
nsv470984 CNV loss 18288195
nsv470985 CNV gain 18288195
nsv527182 CNV loss 19592680
nsv596629 CNV gain 21841781
nsv596788 CNV loss 21841781
nsv596790 CNV loss 21841781
nsv596798 CNV loss 21841781
nsv596803 CNV loss 21841781
nsv822953 CNV gain 20364138
nsv950627 CNV deletion 24416366

Variation tolerance for NKD2 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKD2 Gene

Human Gene Mutation Database (HGMD)
NKD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKD2 Gene

Disorders for NKD2 Gene

Relevant External Links for NKD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKD2

No disorders were found for NKD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKD2 Gene

Publications for NKD2 Gene

  1. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. (PMID: 11356022) Wharton K.A. Jr. … Scott M.P. (Dev. Biol. 2001) 2 3 4 22 64
  2. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. (PMID: 11604995) Katoh M. (Int. J. Oncol. 2001) 2 3 4 22 64
  3. EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. (PMID: 18757723) Ding W. … Coffey R.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64
  4. Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-{alpha} containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. (PMID: 17553928) Li C. … Coffey R.J. (Mol. Biol. Cell 2007) 3 4 64
  5. Structural studies of human Naked2: a biologically active intrinsically unstructured protein. (PMID: 17045239) Hu T. … Coffey R.J. (Biochem. Biophys. Res. Commun. 2006) 3 4 64

Products for NKD2 Gene

Sources for NKD2 Gene

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