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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKD2 Gene

protein-coding   GIFtS: 53
GCID: GC05P001008

Naked Cuticle Homolog 2 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Naked Cuticle Homolog 2 (Drosophila)1 2     Protein Naked Cuticle Homolog 22
Dvl-Binding Protein NKD21 2     Naked-23
Naked Cuticle-21     hNkd23
Naked22     

External Ids:    HGNC: 170461   Entrez Gene: 854092   Ensembl: ENSG000001455067   OMIM: 6078525   UniProtKB: Q969F23   

Export aliases for NKD2 gene to outside databases

Previous GC identifers: GC05P001220 GC05M001180 GC05P001041 GC05P001061 GC05P001062 GC05P000993


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NKD2 Gene:
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling
through interaction with Dishevelled family members. The encoded protein participates in the delivery of
transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Aug 2012)

GeneCards Summary for NKD2 Gene: 
NKD2 (naked cuticle homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with NKD2 include partial fetal alcohol syndrome, and alcohol-related birth defect, and among its related super-pathways are Wnt Signaling Pathway and Wnt Signaling Pathway. GO annotations related to this gene include growth factor binding and calcium ion binding. An important paralog of this gene is NKD1.

UniProtKB/Swiss-Prot: NKD2_HUMAN, Q969F2
Function: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling
pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of
TGFA to the basolateral membrane of polarized epithelial cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKD2 gene promoter:
         Spz1   PPAR-gamma1   p53   HOXA5   HSF1short   HSF1 (long)   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.3

NKD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKD2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P001008:  view genomic region     (about GC identifiers)

Start:
1,008,944 bp from pter      End:
1,039,058 bp from pter
Size:
30,115 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NKD2_HUMAN, Q969F2 (See protein sequence)
Recommended Name: Protein naked cuticle homolog 2  
Size: 451 amino acids; 50055 Da
Subunit: Interacts with DVL1, DVL2, DVL3 and PPP2R3A (By similarity). Interacts with RNF25 and TGFA (via
cytoplasmic domain)
Subcellular location: Cell membrane. Cytoplasm. Cytoplasmic vesicle
Developmental stage: Expressed in fetal kidney and lung
Secondary accessions: Q96EK8 Q9BSN0
Alternative splicing: 2 isoforms:  Q969F2-1   Q969F2-2   

Explore the universe of human proteins at neXtProt for NKD2: NX_Q969F2

Explore proteomics data for NKD2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and
    protects against ubiquitination mediated by RNF25
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969F2

  • NKD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NKD2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258011.1  NP_149111.1  

    ENSEMBL proteins: 
     ENSP00000296849   ENSP00000274150   ENSP00000440925   ENSP00000372177  

    Human Recombinant Protein Products for NKD2: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for NKD2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0016323basolateral plasma membrane IDA17553928
    GO:0016328colocalizes with lateral plasma membrane IDA--
    GO:0031410cytoplasmic vesicle IDA15064403
    GO:0071944cell periphery IDA15064403

    NKD2 for ontologies           About GeneDecksing



    NKD2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    2 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry Q969F2

    ProtoNet protein and cluster: Q969F2

    UniProtKB/Swiss-Prot: NKD2_HUMAN, Q969F2
    Domain: The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured
    Similarity: Belongs to the NKD family
    Similarity: Contains 1 EF-hand domain


    NKD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKD2_HUMAN, Q969F2
    Function: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling
    pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of
    TGFA to the basolateral membrane of polarized epithelial cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15687260
    GO:0019838growth factor binding IPI15064403
    GO:0031625ubiquitin protein ligase binding IPI18757723
         
    NKD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NKD2:
     Decreased Salmonella enterica  

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nkd2):
     behavior/neurological  craniofacial  growth/size  reproductive system  skeleton 

    NKD2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NKD2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NKD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKD2 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NKD2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency0.55
    2Wnt signaling pathway
    Wnt signaling pathway0.40
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    4Canonical Wnt signaling pathway
    Canonical Wnt signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NKD2
        Wnt / Hedgehog / Notch

    2 BioSystems Pathways for NKD2
        Wnt Signaling Pathway and Pluripotency
    Canonical Wnt signaling pathway



    1         Kegg Pathway  (Kegg details for NKD2):
        Wnt signaling pathway


    NKD2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/53 Interacting proteins for NKD2 (Q969F21, 3 ENSP000002968494) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAV1Q031353, ENSP000003391914I2D: score=1 STRING: ENSP00000339191
    RNF25Q96BH13, ENSP000002957044I2D: score=1 STRING: ENSP00000295704
    TGFAP011353, ENSP000002954004I2D: score=3 STRING: ENSP00000295400
    DVL1O146403, ENSP000003681694I2D: score=3 STRING: ENSP00000368169
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0010954positive regulation of protein processing IDA15064403
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP--
    GO:0048210Golgi vesicle fusion to target membrane IMP17553928

    NKD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKD2

    Search CenterWatch for drugs/clinical trials and news about NKD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NKD2 gene (2 alternative transcripts): 
    NM_001271082.1  NM_033120.3  

    Unigene Cluster for NKD2:

    Naked cuticle homolog 2 (Drosophila)
    Hs.240951  [show with all ESTs]
    Unigene Representative Sequence: NM_001271082
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296849(uc003jbt.1) ENST00000274150(uc010itf.1) ENST00000519933
    ENST00000523688 ENST00000513296 ENST00000537972 ENST00000382730
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKD2

    Additional mRNA sequence: 

    AB062887.1 AF358137.1 AK129677.1 BC004940.1 BC012176.1 

    5 DOTS entries:

    DT.100019041  DT.97809542  DT.102822603  DT.95358563  DT.95312527 

    24/28 AceView cDNA sequences (see all 28):

    AA101288 BC004940 AF358137 BX282718 AB062887 NM_033120 BU538030 BU538169 
    BM671346 BP432431 CA421422 BC012176 BM692788 BG479139 AI263890 BQ772705 
    BU726701 BU857988 BE379521 BM687998 BI093620 AA100242 AW205197 BE061409 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NKD2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                          -                             -                           
    SP2:                          -                             -           -               
    SP3:                                                                                    
    SP4:                                                                    -               


    ECgene alternative splicing isoforms for NKD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKD2 expression in normal human tissues (normalized intensities)      NKD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGTGAACA
    NKD2 Expression
    About this image


    NKD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Atrioventricular Node Cells Atrioventricular Node
             Coronary Artery Smooth Muscle Cells (CASMC)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Human Bladder Smooth Muscle Cells (HBdSMC)   
     
     Fibroblast (Uncategorized)    fully expand to see all 3 entries
             Human Lymphatic Fibroblasts (HLF)   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             maxillary prominence tissue e12.5   
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             maxillary prominence tissue e12.5   

    See NKD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKD2

    SOURCE GeneReport for Unigene cluster: Hs.240951

    UniProtKB/Swiss-Prot: NKD2_HUMAN, Q969F2
    Tissue specificity: Expressed in kidney, lung, pancreas and spleen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NKD2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkd21 , 5 naked cuticle 2 homolog (Drosophila)1, 5 79.44(n)1
    78.62(a)1
      13 (40.15 cM)5
    722931  NM_028186.41  NP_082462.31 
     738185345 
    zebrafish
    (Danio rerio)
    Actinopterygii nkd2b1 naked cuticle homolog 2b 56.68(n)
    52.23(a)
      794221  NM_001097586.1  NP_001091055.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nkd6
    naked cuticle
    9(a)
    1 → many
    3L(18996841-19038549)


    ENSEMBL Gene Tree for NKD2 (if available)
    TreeFam Gene Tree for NKD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKD2 gene
    NKD12  
    1 SIMAP similar gene for NKD2 using alignment to 2 protein entries:     NKD2_HUMAN (see all proteins):
    NKD1

    NKD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1171 SNPs in NKD2 are shown (see all 1171)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115357411,2
    C,F--1007225(+) GGAAGG/CGCTGC 2 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1497607791,2
    C--1007230(+) GCTGC-/AAATCC 2 -- us2k10--------
    rs1156917791,2
    F--1007341(+) GAGTTA/GAAGTC 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1502463371,2
    C--1007359(+) GTAGC-/GGCAAG 2 -- us2k10--------
    rs1830082421,2
    --1007446(+) GGCGCC/TCTGAG 2 -- us2k10--------
    rs38108561,2
    C,F,A,H--1007628(-) GATACA/GTGAGC 2 -- us2k122Minor allele frequency- G:0.28NS EA NA WA CSA 2346
    rs38108551,2
    C,F,H--1007667(-) GCCCCC/GCACCC 2 -- us2k16Minor allele frequency- G:0.06EA NS 2016
    rs1425805721,2
    --1007672(+) GGGGGA/CGGGCC 2 -- us2k10--------
    rs1881784481,2
    --1007781(+) AGTAAC/TTGGAG 2 -- us2k10--------
    rs1509743851,2
    --1007879(+) CTCCAA/GCCAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NKD2 (1008944 - 1039058 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/35 variations for NKD2 (see all 35):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2741210CNV Deletion23290073
    esv1007931CNV Deletion20482838
    esv2729380CNV Deletion23290073
    esv990038CNV Deletion20482838
    esv2674300CNV Deletion23128226
    esv2729381CNV Deletion23290073
    esv2729379CNV Deletion23290073
    esv2729382CNV Deletion23290073
    esv2669088CNV Deletion23128226
    nsv461896CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607852    OMIM disorders: --

    11 diseases for NKD2:    About MalaCards
    partial fetal alcohol syndrome    alcohol-related birth defect    alcohol-related neurodevelopmental disorder    birth defects
    fetal alcohol syndrome    strabismus    hyperopia    soft tissue sarcoma
    alcoholism    sarcoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for NKD2:
    Hyperopia

    NKD2 for disorders           About GeneDecksing


    Export disorders for NKD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKD2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with NKD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. (PubMed id 11604995)1, 2, 3, 9 Katoh M. (2001)
    2. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. (PubMed id 11356022)1, 2, 3, 9 Wharton K.A. Jr.... Scott M.P. (2001)
    3. EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. (PubMed id 18757723)1, 2 Ding W....Coffey R.J. (2008)
    4. Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-{alpha} containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. (PubMed id 17553928)1, 2 Li C....Coffey R.J. (2007)
    5. Structural studies of human Naked2: a biologically active intrinsically unstructured protein. (PubMed id 17045239)1, 2 Hu T.... Coffey R.J. (2006)
    6. Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. (PubMed id 15064403)1, 2 Li C....Coffey R.J. (2004)
    7. Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Myristoylated Naked2 antagonizes Wnt-beta-catenin act ivity by degrading Dishevelled-1 at the plasma membrane. (PubMed id 20177058)1 Hu T....Coffey R.J. (2010)
    10. Convergence between Wnt-b-catenin and EGFR signaling i n cancer. (PubMed id 20828404)1 Hu T. and Li C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85409 HGNC: 17046 AceView: NKD2 Ensembl:ENSG00000145506 euGenes: HUgn85409
    ECgene: NKD2 Kegg: 85409 H-InvDB: NKD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NKD2 gene:
    Search GeneIP for patents involving NKD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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