Aliases for NKD2 Gene
External Ids for NKD2 Gene
Previous GeneCards Identifiers for NKD2 Gene
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for NKD2 Gene
NKD2 (Naked Cuticle Homolog 2) is a Protein Coding gene. Among its related pathways are S45 mutants of beta-catenin arent phosphorylated and Wnt signaling pathway (KEGG). GO annotations related to this gene include calcium ion binding and growth factor binding. An important paralog of this gene is NKD1.
UniProtKB/Swiss-Prot for NKD2 Gene
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.