Aliases for NKD2 Gene
External Ids for NKD2 Gene
Previous GeneCards Identifiers for NKD2 Gene
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
GeneCards Summary for NKD2 Gene
NKD2 (Naked Cuticle Homolog 2 (Drosophila)) is a Protein Coding gene. Among its related pathways are Wnt / Hedgehog / Notch and S45 mutants of beta-catenin arent phosphorylated. GO annotations related to this gene include calcium ion binding and growth factor binding. An important paralog of this gene is NKD1.
UniProtKB/Swiss-Prot for NKD2 Gene
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.