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Aliases for NKD2 Gene

Aliases for NKD2 Gene

  • Naked Cuticle Homolog 2 (Drosophila) 2 3
  • Dvl-Binding Protein NKD2 2 3
  • Protein Naked Cuticle Homolog 2 3
  • Naked Cuticle-2 2
  • Naked-2 4
  • Naked2 3
  • HNkd2 4

External Ids for NKD2 Gene

Summaries for NKD2 Gene

Entrez Gene Summary for NKD2 Gene

  • This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for NKD2 Gene

NKD2 (Naked Cuticle Homolog 2 (Drosophila)) is a Protein Coding gene. Among its related pathways are Wnt / Hedgehog / Notch and Wnt Signaling Pathway (WikiPathways). GO annotations related to this gene include calcium ion binding and growth factor binding. An important paralog of this gene is NKD1.

UniProtKB/Swiss-Prot for NKD2 Gene

  • Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKD2 Gene

Genomics for NKD2 Gene

Genomic Location for NKD2 Gene

Start:
1,008,826 bp from pter
End:
1,038,943 bp from pter
Size:
30,118 bases
Orientation:
Plus strand

Genomic View for NKD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKD2 Gene

Regulatory Elements for NKD2 Gene

Proteins for NKD2 Gene

  • Protein details for NKD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969F2-NKD2_HUMAN
    Recommended name:
    Protein naked cuticle homolog 2
    Protein Accession:
    Q969F2
    Secondary Accessions:
    • Q96EK8
    • Q9BSN0

    Protein attributes for NKD2 Gene

    Size:
    451 amino acids
    Molecular mass:
    50055 Da
    Quaternary structure:
    • Interacts with DVL1, DVL2, DVL3 and PPP2R3A (By similarity). Interacts with RNF25 and TGFA (via cytoplasmic domain).

    Alternative splice isoforms for NKD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKD2 Gene

Proteomics data for NKD2 Gene at MOPED

Post-translational modifications for NKD2 Gene

  • Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKD2 Gene

Domains for NKD2 Gene

Gene Families for NKD2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for NKD2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NKD2_HUMAN
Domain:
  • The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured.:
    • Q969F2
  • Contains 1 EF-hand domain.:
    • Q969F2
Family:
  • Belongs to the NKD family.:
    • Q969F2
genes like me logo Genes that share domains with NKD2: view

Function for NKD2 Gene

Molecular function for NKD2 Gene

UniProtKB/Swiss-Prot Function: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.

Gene Ontology (GO) - Molecular Function for NKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15687260
GO:0019838 growth factor binding IPI 15064403
GO:0031625 ubiquitin protein ligase binding IPI 18757723
genes like me logo Genes that share ontologies with NKD2: view
genes like me logo Genes that share phenotypes with NKD2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NKD2 Gene

Localization for NKD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKD2 Gene

Cell membrane. Cytoplasm. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKD2 Gene COMPARTMENTS Subcellular localization image for NKD2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0016323 basolateral plasma membrane IDA 17553928
GO:0016328 colocalizes_with lateral plasma membrane IDA 20177058
GO:0031410 cytoplasmic vesicle IDA 15064403
GO:0071944 cell periphery IDA 15064403
genes like me logo Genes that share ontologies with NKD2: view

Pathways for NKD2 Gene

genes like me logo Genes that share pathways with NKD2: view

Pathways by source for NKD2 Gene

1 Cell Signaling Technology pathway for NKD2 Gene
1 KEGG pathway for NKD2 Gene

Gene Ontology (GO) - Biological Process for NKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0010954 positive regulation of protein processing IDA 15064403
GO:0016055 Wnt signaling pathway IEA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 20177058
GO:0048210 Golgi vesicle fusion to target membrane IMP 17553928
genes like me logo Genes that share ontologies with NKD2: view

Transcripts for NKD2 Gene

Unigene Clusters for NKD2 Gene

Naked cuticle homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKD2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for NKD2 Gene

GeneLoc Exon Structure for
NKD2
ECgene alternative splicing isoforms for
NKD2

Expression for NKD2 Gene

mRNA expression in normal human tissues for NKD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKD2 Gene

This gene is overexpressed in Lung (9.7) and Spleen (5.1).

SOURCE GeneReport for Unigene cluster for NKD2 Gene Hs.240951

mRNA Expression by UniProt/SwissProt for NKD2 Gene

Q969F2-NKD2_HUMAN
Tissue specificity: Expressed in kidney, lung, pancreas and spleen.
genes like me logo Genes that share expressions with NKD2: view

Orthologs for NKD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKD2 36
  • 95.25 (n)
  • 93.96 (a)
NKD2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKD2 36
  • 78.43 (n)
  • 74.84 (a)
NKD2 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKD2 36
  • 79.55 (n)
  • 72.58 (a)
NKD2 37
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkd2 36
  • 78.89 (n)
  • 77.57 (a)
Nkd2 16
Nkd2 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKD2 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKD2 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkd2 36
  • 79.67 (n)
  • 78.01 (a)
zebrafish
(Danio rerio)
Actinopterygii nkd2a 37
  • 50 (a)
OneToOne
nkd2b 36
  • 55.15 (n)
  • 50.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta nkd 37
  • 11 (a)
OneToMany
Species with no ortholog for NKD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKD2 Gene

ENSEMBL:
Gene Tree for NKD2 (if available)
TreeFam:
Gene Tree for NKD2 (if available)

Paralogs for NKD2 Gene

Paralogs for NKD2 Gene

Selected SIMAP similar genes for NKD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NKD2: view

Variants for NKD2 Gene

Sequence variations from dbSNP and Humsavar for NKD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs879352 -- 1,012,471(-) AGGGC(C/T)GTGGC intron-variant
rs881334 -- 1,030,530(-) ATAAT(A/G)GGTGA intron-variant
rs881335 -- 1,030,425(-) GATAC(C/T)AGGAG intron-variant
rs882622 -- 1,029,597(+) GCTGC(A/G)TTTAC intron-variant
rs882623 -- 1,029,736(+) CTGCC(C/T)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKD2 Gene

Variant ID Type Subtype PubMed ID
nsv881103 CNV Gain 21882294
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
nsv10654 CNV Gain+Loss 18304495
nsv880488 CNV Gain 21882294
nsv880383 CNV Gain 21882294
nsv881169 CNV Loss 21882294
nsv880554 CNV Gain 21882294
dgv5907n71 CNV Loss 21882294
dgv5908n71 CNV Loss 21882294
nsv469577 CNV Loss 16826518
nsv880538 CNV Gain 21882294
nsv470985 CNV Gain 18288195
nsv461896 CNV Loss 19166990
nsv470984 CNV Loss 18288195
nsv527182 CNV Loss 19592680
nsv880941 CNV Gain+Loss 21882294
esv2669088 CNV Deletion 23128226
esv27512 CNV Gain+Loss 19812545
nsv881571 CNV Loss 21882294
nsv822953 CNV Gain 20364138
dgv686n27 CNV Loss 19166990
dgv5909n71 CNV Loss 21882294
dgv5910n71 CNV Loss 21882294
esv1007931 CNV Deletion 20482838
esv999700 CNV Gain 20482838
esv2729379 CNV Deletion 23290073
esv990038 CNV Deletion 20482838
nsv880448 CNV Gain 21882294
esv2729380 CNV Deletion 23290073
esv2741210 CNV Deletion 23290073
esv2729381 CNV Deletion 23290073
nsv329395 CNV Loss 16902084
esv2674300 CNV Deletion 23128226
esv2729382 CNV Deletion 23290073

Relevant External Links for NKD2 Gene

HapMap Linkage Disequilibrium report
NKD2
Human Gene Mutation Database (HGMD)
NKD2

Disorders for NKD2 Gene

(1) University of Copenhagen DISEASES for NKD2 Gene

genes like me logo Genes that share disorders with NKD2: view

No data available for UniProtKB/Swiss-Prot for NKD2 Gene

Publications for NKD2 Gene

  1. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. (PMID: 11356022) Wharton K.A. Jr. … Scott M.P. (Dev. Biol. 2001) 2 3 4 23
  2. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. (PMID: 11604995) Katoh M. (Int. J. Oncol. 2001) 2 3 4 23
  3. Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. (PMID: 15064403) Li C. … Coffey R.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Structural studies of human Naked2: a biologically active intrinsically unstructured protein. (PMID: 17045239) Hu T. … Coffey R.J. (Biochem. Biophys. Res. Commun. 2006) 3 4
  5. EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. (PMID: 18757723) Ding W. … Coffey R.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4

Products for NKD2 Gene

Sources for NKD2 Gene

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