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NKD1 Gene

protein-coding   GIFtS: 49
GCID: GC16P050582

Naked Cuticle Homolog 1 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Naked Cuticle Homolog 1 (Drosophila)1 2     Protein Naked Cuticle Homolog 12
Naked12     NKD3
Dvl-Binding Protein2     Naked-13
Naked Cuticle-12     hNkd3
naked-12     hNkd13

External Ids:    HGNC: 170451   Entrez Gene: 854072   Ensembl: ENSG000001408077   OMIM: 6078515   UniProtKB: Q969G93   

Export aliases for NKD1 gene to outside databases

Previous GC identifers: GC16P040995 GC16P050629 GC16P050319 GC16P050360 GC16P049139 GC16P036470


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NKD1 Gene:
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator
of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.(supplied
by OMIM, Jun 2003)

GeneCards Summary for NKD1 Gene:
NKD1 (naked cuticle homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with NKD1 include strabismus, and hyperopia. GO annotations related to this gene include PDZ domain binding and calcium ion binding. An important paralog of this gene is NKD2.

UniProtKB/Swiss-Prot: NKD1_HUMAN, Q969G9
Function: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling
pathway that controls planar cell polarity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKD1 gene promoter:
         PPAR-gamma1   AP-4   PPAR-gamma2   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKD1 promoter sequence
   Search Chromatin IP Primers for NKD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

NKD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKD1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P050582:  view genomic region     (about GC identifiers)

Start:
50,582,241 bp from pter      End:
50,674,771 bp from pter
Size:
92,531 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NKD1_HUMAN, Q969G9 (See protein sequence)
Recommended Name: Protein naked cuticle homolog 1  
Size: 470 amino acids; 52285 Da
Subunit: Interacts with DVL1, DVL2, DVL3 and PPP2R3A
Developmental stage: Expressed in fetal brain, kidney, liver and lung
Secondary accessions: B2RC39 Q8WZ08

Explore the universe of human proteins at neXtProt for NKD1: NX_Q969G9

Explore proteomics data for NKD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NKD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149110.1  
    ENSEMBL proteins: 
     ENSP00000268459  

    NKD1 Human Recombinant Protein Products:

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    NKD1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NKD1
    Cloud-Clone Corp. CLIAs for NKD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q969G9

    ProtoNet protein and cluster: Q969G9

    UniProtKB/Swiss-Prot: NKD1_HUMAN, Q969G9
    Similarity: Belongs to the NKD family
    Similarity: Contains 1 EF-hand domain


    NKD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKD1_HUMAN, Q969G9
    Function: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling
    pathway that controls planar cell polarity
    Induction: Expression is induced by activation of the Wnt signaling pathway

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15687260
    GO:0030165PDZ domain binding IEA--
         
    NKD1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nkd1):
     behavior/neurological  craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     reproductive system  skeleton 

    NKD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nkd1tm1Tko for NKD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NKD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NKD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NKD1:
    hsa-mir-24-3p (MIRT030499)

    Block miRNA regulation of human, mouse, rat NKD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NKD1 (see all 82):
    hsa-miR-100* hsa-miR-642a hsa-miR-607 hsa-miR-188-5p hsa-miR-15a hsa-miR-605 hsa-miR-3122 hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidNKD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NKD1
    Predesigned siRNA for gene silencing in human, mouse, rat NKD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NKD1

    Clone
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    OriGene clones in human, mouse for NKD1 (see all 6)
    OriGene ORF clones in mouse, rat for NKD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NKD1 (NM_033119)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKD1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NKD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NKD1_HUMAN, Q969G9: Cell membrane (By similarity). Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000159colocalizes with protein phosphatase type 2A complex IDA15687260
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    NKD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NKD1 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    4Presenilin action in Notch and Wnt signaling
    Presenilin action in Notch and Wnt signaling
    5Hippo signaling pathway
    Hippo signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NKD1
        Wnt / Hedgehog / Notch

    3 BioSystems Pathways for NKD1
        Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Presenilin action in Notch and Wnt signaling


    2 Kegg Pathways  (Kegg details for NKD1):
        Wnt signaling pathway
    Hippo signaling pathway


    NKD1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NKD1: 
              WNT Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NKD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NKD1 (Q969G91, 3 ENSP000002684594) via UniProtKB, MINT, STRING, and/or I2D (see all 147)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206468O152053I2D: score=1 
    ENSG00000228913O152053I2D: score=1 
    ENSG00000231968O152053I2D: score=1 
    UBDO152053I2D: score=1 
    PPP2R1AP301533, ENSP000003248044I2D: score=1 STRING: ENSP00000324804
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001754eye photoreceptor cell differentiation ISS15687260
    GO:0007525somatic muscle development ISS15687260
    GO:0016055Wnt signaling pathway IEA--
    GO:0030178negative regulation of Wnt signaling pathway ----
    GO:0045732positive regulation of protein catabolic process IMP15687260

    NKD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NKD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NKD1 gene: 
    NM_033119.4  

    Unigene Cluster for NKD1:

    Naked cuticle homolog 1 (Drosophila)
    Hs.187578  [show with all ESTs]
    Unigene Representative Sequence: NM_033119
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268459(uc002egg.2) ENST00000564336 ENST00000566396
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NKD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NKD1 (see all 82):
    hsa-miR-100* hsa-miR-642a hsa-miR-607 hsa-miR-188-5p hsa-miR-15a hsa-miR-605 hsa-miR-3122 hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidNKD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NKD1
    Predesigned siRNA for gene silencing in human, mouse, rat NKD1
    Clone
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    OriGene clones in human, mouse for NKD1 (see all 6)
    OriGene ORF clones in mouse, rat for NKD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NKD1 (NM_033119)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKD1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NKD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NKD1
      QuantiTect SYBR Green Assays in human, mouse, rat NKD1
      QuantiFast Probe-based Assays in human, mouse, rat NKD1

    Additional mRNA sequence: 

    AB062886.1 AF289584.1 AF358135.1 AK000276.1 AK021701.1 AK023784.1 AK314930.1 AY061883.1 
    BC051288.1 

    5 DOTS entries:

    DT.92046947  DT.92015373  DT.203755  DT.453967  DT.91673444 

    Selected AceView cDNA sequences (see all 56):

    BU846054 AI884849 AF358135 AW268418 CD675898 AB062886 BG820139 NM_033119 
    BQ645656 AY061883 CB215756 BQ644956 BC051288 BQ653673 D11959 BQ064678 
    AK000276 BQ644360 AI350714 BM711145 AI990367 AA262960 AI167910 BM670652 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NKD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NKD1 Expression
    About this image


    NKD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm
     
     Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
    NKD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NKD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.187578

    UniProtKB/Swiss-Prot: NKD1_HUMAN, Q969G9
    Tissue specificity: Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta,
    prostate, skeletal muscle, small intestine and spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including NKD1: 
              WNT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NKD1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkd11 , 5 naked cuticle 1 homolog (Drosophila)1, 5 86(n)1
    87.42(a)1
      8 (43.36 cM)5
    939601  NM_027280.31  NP_081556.31 
     885213445 
    chicken
    (Gallus gallus)
    Aves NKD11 naked cuticle homolog 1 (Drosophila) 66.52(n)
    66.67(a)
      415729  XM_414094.4  XP_414094.3 
    lizard
    (Anolis carolinensis)
    Reptilia NKD16
    naked cuticle homolog 1 (Drosophila)
    60(a)
    1 ↔ 1
    GL343227.1(1313029-1492274)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nkd11 naked cuticle homolog 1 60.43(n)
    56.12(a)
      549552  NM_001016798.2  NP_001016798.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nkd11 naked cuticle homolog 1 (Drosophila) 58.49(n)
    53.47(a)
      751108  NM_001043333.1  NP_001036798.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nkd6
    naked cuticle
    11(a)
    1 → many
    3L(18996841-19038549)


    ENSEMBL Gene Tree for NKD1 (if available)
    TreeFam Gene Tree for NKD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NKD1 gene
    NKD22  
    1 SIMAP similar gene for NKD1 using alignment to 1 protein entry:     NKD1_HUMAN:
    NKD2

    NKD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NKD1 (see all 1577)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs575953401,2
    C,F--50580271(+) CACCTC/TTCTGA 1 -- us2k13Minor allele frequency- T:0.07WA CSA 122
    rs590276581,2
    F--50580304(+) TAGAAC/GAAGTA 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1439437351,2
    --50580335(+) GTTGCA/GAGGGC 1 -- us2k10--------
    rs71995231,2
    C,F,A,H--50580414(+) CAACAG/ATAATA 1 -- us2k1 tfbs37Minor allele frequency- A:0.05NS EA NA WA 540
    rs587193511,2
    C,F--50580442(+) CACTCC/TTCAAA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1433713481,2
    C--50580688(+) ATATGA/GCTAGT 1 -- us2k10--------
    rs1467262061,2
    --50580746(+) TTAGCA/GCAATA 1 -- us2k10--------
    rs735879731,2
    C,F--50580833(+) GGACTG/TGTTCC 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1844038421,2
    --50580869(+) CCAGAC/TGTCAA 1 -- us2k10--------
    rs1393643141,2
    --50580870(+) CAGATA/GTCAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NKD1 (50582241 - 50674771 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NKD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714459CNV Deletion23290073
    esv2714461CNV Deletion23290073
    esv2714460CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NKD1
    DNA2.0 Custom Variant and Variant Library Synthesis for NKD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607851    OMIM disorders: --

    6 diseases for NKD1:    
    About MalaCards
    strabismus    hyperopia    crohn's disease    colorectal cancer
    lung cancer    prostatitis


    NKD1 for disorders           About GeneDecksing


    Export disorders for NKD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKD1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with NKD1)
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    1. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. (PubMed id 11356022)1, 2, 3, 9 Wharton K.A. Jr.... Scott M.P. (Dev. Biol. 2001)
    2. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. (PubMed id 11604995)1, 2, 9 Katoh M. (Int. J. Oncol. 2001)
    3. PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle. (PubMed id 16567647)1, 2 Creyghton M.P....Bernards R. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    4. PR72, a novel regulator of Wnt signaling required for Naked cuticle function. (PubMed id 15687260)1, 2 Creyghton M.P.... Bernards R. (Genes Dev. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta-catenin signaling is activated in human colon tumors. (PubMed id 11752446)1, 2 Yan D.... Williams L.T. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    7. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (PLoS Genet. 2012)
    8. Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis. (PubMed id 21599923)1 Zhang S....Wang E.H. (BMC Cancer 2011)
    9. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. (PubMed id 19956716)1 Guo J....Liu W. (PLoS ONE 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85407 HGNC: 17045 AceView: NKD1 Ensembl:ENSG00000140807 euGenes: HUgn85407
    ECgene: NKD1 Kegg: 85407 H-InvDB: NKD1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NKD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NKD1 gene:
    Search GeneIP for patents involving NKD1

    GeneCards and IP:
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