Aliases for NKD1 Gene
External Ids for NKD1 Gene
Previous GeneCards Identifiers for NKD1 Gene
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
GeneCards Summary for NKD1 Gene
NKD1 (Naked Cuticle Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with NKD1 include chronic nk-cell lymphocytosis. Among its related pathways are Hippo signaling pathway and Wnt / Hedgehog / Notch. GO annotations related to this gene include calcium ion binding and PDZ domain binding. An important paralog of this gene is NKD2.
UniProtKB/Swiss-Prot for NKD1 Gene
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.