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Aliases for NKD1 Gene

Aliases for NKD1 Gene

  • Naked Cuticle Homolog 1 2 3 5
  • Naked-1 3 4
  • Naked Cuticle Homolog 1 (Drosophila) 2
  • Protein Naked Cuticle Homolog 1 3
  • Dvl-Binding Protein 3
  • Naked Cuticle-1 3
  • Naked1 3
  • HNkd1 4
  • HNkd 4
  • NKD 4

External Ids for NKD1 Gene

Previous GeneCards Identifiers for NKD1 Gene

  • GC16P040995
  • GC16P050629
  • GC16P050319
  • GC16P050360
  • GC16P049139
  • GC16P036470
  • GC16P050582

Summaries for NKD1 Gene

Entrez Gene Summary for NKD1 Gene

  • In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

GeneCards Summary for NKD1 Gene

NKD1 (Naked Cuticle Homolog 1) is a Protein Coding gene. Diseases associated with NKD1 include Chronic Nk-Cell Lymphocytosis. Among its related pathways are Presenilin action in Notch and Wnt signaling and Wnt Signaling Pathway and Pluripotency. GO annotations related to this gene include calcium ion binding and PDZ domain binding. An important paralog of this gene is NKD2.

UniProtKB/Swiss-Prot for NKD1 Gene

  • Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.

Additional gene information for NKD1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKD1 Gene

Genomics for NKD1 Gene

Regulatory Elements for NKD1 Gene

Enhancers for NKD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H050520 1.3 FANTOM5 ENCODE 18.4 -27.6 -27579 0.4 FOXA2 ATF1 MLX ARID4B DMAP1 SLC30A9 SP5 MXD4 MIER2 PPARG NKD1 ENSG00000205414 BRD7 GC16M050509
GH16H050599 1.2 Ensembl ENCODE dbSUPER 15.2 +53.9 53896 4.8 ZMYM3 MAX CEBPG POLR2A ZNF143 RUNX3 EGR2 NFIA CEBPB NR2F2 NKD1 ENSG00000205414 PIR48968
GH16H050626 1 Ensembl ENCODE dbSUPER 18 +79.2 79174 1.3 CTCF SCRT2 RAD21 NKD1 BRD7 PIR55860 ENSG00000205414
GH16H050539 1 FANTOM5 17.8 -9.0 -8975 0.3 ELF3 TBP FOXA2 ATF1 MLX ARID4B DMAP1 RAD21 DNMT3B THRB NKD1 BRD7 GC16M050509
GH16H050615 1.1 ENCODE dbSUPER 11 +68.6 68555 3.3 ELF3 FOXA2 ARID4B DNMT3B THRB ZBTB40 CREM MIXL1 HMG20B SP5 NKD1 BRD7 SALL1 ENSG00000205414 PIR55860
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NKD1 on UCSC Golden Path with GeneCards custom track

Promoters for NKD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085793 -30 1401 FOXA2 MLX ARID4B DMAP1 TCF12 GLIS2 ZNF143 RUNX3 SP5 MXD4

Genomic Locations for NKD1 Gene

Genomic Locations for NKD1 Gene
100,920 bases
Plus strand

Genomic View for NKD1 Gene

Genes around NKD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKD1 Gene

Proteins for NKD1 Gene

  • Protein details for NKD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein naked cuticle homolog 1
    Protein Accession:
    Secondary Accessions:
    • B2RC39
    • Q8WZ08

    Protein attributes for NKD1 Gene

    470 amino acids
    Molecular mass:
    52285 Da
    Quaternary structure:
    • Interacts with DVL1, DVL2, DVL3 and PPP2R3A.

neXtProt entry for NKD1 Gene

Post-translational modifications for NKD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKD1 Gene

No data available for DME Specific Peptides for NKD1 Gene

Domains & Families for NKD1 Gene

Gene Families for NKD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NKD1 Gene

Suggested Antigen Peptide Sequences for NKD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NKD family.
  • Belongs to the NKD family.
genes like me logo Genes that share domains with NKD1: view

Function for NKD1 Gene

Molecular function for NKD1 Gene

UniProtKB/Swiss-Prot Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
UniProtKB/Swiss-Prot Induction:
Expression is induced by activation of the Wnt signaling pathway.

Phenotypes From GWAS Catalog for NKD1 Gene

Gene Ontology (GO) - Molecular Function for NKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15687260
GO:0030165 PDZ domain binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NKD1: view
genes like me logo Genes that share phenotypes with NKD1: view

Animal Models for NKD1 Gene

MGI Knock Outs for NKD1:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKD1 Gene

Localization for NKD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKD1 Gene

Cell membrane. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKD1 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 colocalizes_with protein phosphatase type 2A complex IDA 15687260
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NKD1: view

Pathways & Interactions for NKD1 Gene

genes like me logo Genes that share pathways with NKD1: view

Pathways by source for NKD1 Gene

1 GeneTex pathway for NKD1 Gene
1 Cell Signaling Technology pathway for NKD1 Gene

SIGNOR curated interactions for NKD1 Gene


Gene Ontology (GO) - Biological Process for NKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001754 eye photoreceptor cell differentiation ISS 15687260
GO:0007525 somatic muscle development ISS 15687260
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IEA --
GO:0045732 positive regulation of protein catabolic process IMP 15687260
genes like me logo Genes that share ontologies with NKD1: view

Drugs & Compounds for NKD1 Gene

No Compound Related Data Available

Transcripts for NKD1 Gene

Unigene Clusters for NKD1 Gene

Naked cuticle homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKD1 Gene

No ASD Table

Relevant External Links for NKD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKD1 Gene

This gene is overexpressed in Artery - Tibial (x4.6).

Protein differential expression in normal tissues from HIPED for NKD1 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NKD1 Gene

Protein tissue co-expression partners for NKD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NKD1 Gene:


SOURCE GeneReport for Unigene cluster for NKD1 Gene:


mRNA Expression by UniProt/SwissProt for NKD1 Gene:

Tissue specificity: Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.

Evidence on tissue expression from TISSUES for NKD1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NKD1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NKD1 Gene

Orthologs for NKD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NKD1 33 34
  • 99.19 (n)
(Canis familiaris)
Mammalia NKD1 33 34
  • 89.57 (n)
(Bos Taurus)
Mammalia NKD1 33 34
  • 88.94 (n)
(Rattus norvegicus)
Mammalia Nkd1 33
  • 86.07 (n)
(Mus musculus)
Mammalia Nkd1 33 16 34
  • 86 (n)
(Monodelphis domestica)
Mammalia NKD1 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia NKD1 34
  • 70 (a)
(Gallus gallus)
Aves NKD1 33 34
  • 66.52 (n)
(Anolis carolinensis)
Reptilia NKD1 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nkd1 33
  • 60.43 (n)
(Danio rerio)
Actinopterygii nkd1 33 34
  • 58.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta nkd 34
  • 11 (a)
Species where no ortholog for NKD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKD1 Gene

Gene Tree for NKD1 (if available)
Gene Tree for NKD1 (if available)

Paralogs for NKD1 Gene

Paralogs for NKD1 Gene

(1) SIMAP similar genes for NKD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKD1: view

Variants for NKD1 Gene

Sequence variations from dbSNP and Humsavar for NKD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000008626 -- 50,608,206(+) AATCA(A/G)CCCAG intron-variant, upstream-variant-2KB
rs1000086635 -- 50,582,150(+) GCCCA(A/G)GGATG intron-variant
rs1000092462 -- 50,647,583(+) GCCCA(C/T)GTGGA utr-variant-3-prime
rs1000118076 -- 50,564,153(+) TGTTC(A/C)GGCTT intron-variant
rs1000127318 -- 50,638,074(+) TCTCA(C/G)TGTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NKD1 Gene

Variant ID Type Subtype PubMed ID
esv2714461 CNV deletion 23290073
esv2714460 CNV deletion 23290073
esv2714459 CNV deletion 23290073

Variation tolerance for NKD1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKD1 Gene

Disorders for NKD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NKD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic nk-cell lymphocytosis
  • nk-cell large granular lymphocyte lymphocytosis
- elite association - COSMIC cancer census association via MalaCards
Search NKD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NKD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NKD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NKD1 Gene

Publications for NKD1 Gene

  1. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. (PMID: 11356022) Wharton KA … Scott MP (Developmental biology 2001) 2 3 4 22 60
  2. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. (PMID: 11604995) Katoh M (International journal of oncology 2001) 3 4 22 60
  3. PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle. (PMID: 16567647) Creyghton MP … Bernards R (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 60
  4. PR72, a novel regulator of Wnt signaling required for Naked cuticle function. (PMID: 15687260) Creyghton MP … Bernards R (Genes & development 2005) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for NKD1 Gene

Sources for NKD1 Gene

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