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Aliases for NKD1 Gene

Aliases for NKD1 Gene

  • Naked Cuticle Homolog 1 2 3
  • Naked Cuticle Homolog 1 (Drosophila) 2 5
  • Naked-1 3 4
  • Dvl-Binding Protein 3
  • Naked Cuticle-1 3
  • Naked1 3
  • HNkd1 4
  • HNkd 4
  • NKD 4

External Ids for NKD1 Gene

Previous GeneCards Identifiers for NKD1 Gene

  • GC16P040995
  • GC16P050629
  • GC16P050319
  • GC16P050360
  • GC16P049139
  • GC16P036470
  • GC16P050582

Summaries for NKD1 Gene

Entrez Gene Summary for NKD1 Gene

  • In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

GeneCards Summary for NKD1 Gene

NKD1 (Naked Cuticle Homolog 1) is a Protein Coding gene. Diseases associated with NKD1 include Chronic Nk-Cell Lymphocytosis. Among its related pathways are Wnt signaling pathway (KEGG) and Presenilin action in Notch and Wnt signaling. GO annotations related to this gene include calcium ion binding and PDZ domain binding. An important paralog of this gene is NKD2.

UniProtKB/Swiss-Prot for NKD1 Gene

  • Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKD1 Gene

Genomics for NKD1 Gene

Regulatory Elements for NKD1 Gene

Enhancers for NKD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NKD1 on UCSC Golden Path with GeneCards custom track

Promoters for NKD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NKD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NKD1 Gene

50,548,330 bp from pter
50,649,249 bp from pter
100,920 bases
Plus strand

Genomic View for NKD1 Gene

Genes around NKD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKD1 Gene

Proteins for NKD1 Gene

  • Protein details for NKD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein naked cuticle homolog 1
    Protein Accession:
    Secondary Accessions:
    • B2RC39
    • Q8WZ08

    Protein attributes for NKD1 Gene

    470 amino acids
    Molecular mass:
    52285 Da
    Quaternary structure:
    • Interacts with DVL1, DVL2, DVL3 and PPP2R3A.

neXtProt entry for NKD1 Gene

Proteomics data for NKD1 Gene at MOPED

Post-translational modifications for NKD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NKD1 (NKD1)

No data available for DME Specific Peptides for NKD1 Gene

Domains & Families for NKD1 Gene

Gene Families for NKD1 Gene

Protein Domains for NKD1 Gene

Suggested Antigen Peptide Sequences for NKD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EF-hand domain.
  • Belongs to the NKD family.
  • Contains 1 EF-hand domain.
  • Belongs to the NKD family.
genes like me logo Genes that share domains with NKD1: view

Function for NKD1 Gene

Molecular function for NKD1 Gene

UniProtKB/Swiss-Prot Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
UniProtKB/Swiss-Prot Induction:
Expression is induced by activation of the Wnt signaling pathway.
genes like me logo Genes that share phenotypes with NKD1: view

Animal Models for NKD1 Gene

MGI Knock Outs for NKD1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKD1 Gene

Localization for NKD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKD1 Gene

Cell membrane. Cytoplasm.

Subcellular locations from

Jensen Localization Image for NKD1 Gene COMPARTMENTS Subcellular localization image for NKD1 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NKD1 Gene

Pathways & Interactions for NKD1 Gene

genes like me logo Genes that share pathways with NKD1: view

Pathways by source for NKD1 Gene

1 GeneTex pathway for NKD1 Gene
1 Cell Signaling Technology pathway for NKD1 Gene

SIGNOR curated interactions for NKD1 Gene


Gene Ontology (GO) - Biological Process for NKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007525 somatic muscle development ISS 15687260
GO:0016055 Wnt signaling pathway IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IEA,ISS --
GO:0090249 regulation of cell motility involved in somitogenic axis elongation ISS 15687260
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA,ISS --
genes like me logo Genes that share ontologies with NKD1: view

Drugs & Compounds for NKD1 Gene

No Compound Related Data Available

Transcripts for NKD1 Gene

Unigene Clusters for NKD1 Gene

Naked cuticle homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKD1 Gene

No ASD Table

Relevant External Links for NKD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKD1 Gene

mRNA expression in normal human tissues for NKD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKD1 Gene

This gene is overexpressed in Artery - Tibial (x4.6).

Protein differential expression in normal tissues from HIPED for NKD1 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NKD1 Gene

SOURCE GeneReport for Unigene cluster for NKD1 Gene Hs.187578

mRNA Expression by UniProt/SwissProt for NKD1 Gene

Tissue specificity: Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.
genes like me logo Genes that share expression patterns with NKD1: view

Protein tissue co-expression partners for NKD1 Gene

Primer Products

Orthologs for NKD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NKD1 35
  • 88.94 (n)
  • 89.79 (a)
NKD1 36
  • 90 (a)
(Canis familiaris)
Mammalia NKD1 35
  • 89.57 (n)
  • 89.36 (a)
NKD1 36
  • 89 (a)
(Mus musculus)
Mammalia Nkd1 35
  • 86 (n)
  • 87.42 (a)
Nkd1 16
Nkd1 36
  • 87 (a)
(Pan troglodytes)
Mammalia NKD1 35
  • 99.19 (n)
  • 98.9 (a)
NKD1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nkd1 35
  • 86.07 (n)
  • 85.29 (a)
(Monodelphis domestica)
Mammalia NKD1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia NKD1 36
  • 70 (a)
(Gallus gallus)
Aves NKD1 35
  • 66.52 (n)
  • 66.67 (a)
NKD1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia NKD1 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nkd1 35
  • 60.43 (n)
  • 56.12 (a)
(Danio rerio)
Actinopterygii nkd1 35
  • 58.49 (n)
  • 53.47 (a)
nkd1 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta nkd 36
  • 11 (a)
Species with no ortholog for NKD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKD1 Gene

Gene Tree for NKD1 (if available)
Gene Tree for NKD1 (if available)

Paralogs for NKD1 Gene

Paralogs for NKD1 Gene

(1) SIMAP similar genes for NKD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKD1: view

Variants for NKD1 Gene

Sequence variations from dbSNP and Humsavar for NKD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs12913 -- 50,634,515(-) TGAGA(A/G)GGATG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs8064092 -- 50,558,718(+) aaaat(A/C)caaaa intron-variant
rs9673419 -- 50,627,362(+) GTTTC(A/C)ACCTG intron-variant
rs4486887 -- 50,643,660(+) aacta(C/T)tgatc intron-variant
rs13334096 -- 50,555,165(+) CTGAC(C/T)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKD1 Gene

Variant ID Type Subtype PubMed ID
esv2714459 CNV Deletion 23290073
esv2714460 CNV Deletion 23290073
esv2714461 CNV Deletion 23290073

Variation tolerance for NKD1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NKD1 Gene

Disorders for NKD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NKD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic nk-cell lymphocytosis
  • nk-cell large granular lymphocyte lymphocytosis
- elite association - COSMIC cancer census association via MalaCards
Search NKD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NKD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NKD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NKD1 Gene

Publications for NKD1 Gene

  1. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. (PMID: 11356022) Wharton K.A. Jr. … Scott M.P. (Dev. Biol. 2001) 2 3 4 23 67
  2. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. (PMID: 11604995) Katoh M. (Int. J. Oncol. 2001) 3 23
  3. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3
  4. Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis. (PMID: 21599923) Zhang S. … Wang E.H. (BMC Cancer 2011) 3
  5. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. (PMID: 19956716) Guo J. … Liu W. (PLoS ONE 2009) 3

Products for NKD1 Gene

Sources for NKD1 Gene