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Aliases for NKAPL Gene

Aliases for NKAPL Gene

  • NFKB Activating Protein-Like 2 3
  • C6orf194 3 4
  • Chromosome 6 Open Reading Frame 194 2
  • NKAP-Like Protein 3
  • BA424I5.1 3

External Ids for NKAPL Gene

Previous Symbols for NKAPL Gene

  • C6orf194

Summaries for NKAPL Gene

GeneCards Summary for NKAPL Gene

NKAPL (NFKB Activating Protein-Like) is a Protein Coding gene. An important paralog of this gene is NKAP.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAPL Gene

Genomics for NKAPL Gene

Genomic Location for NKAPL Gene

Start:
28,259,297 bp from pter
End:
28,260,958 bp from pter
Size:
1,662 bases
Orientation:
Plus strand

Genomic View for NKAPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAPL Gene

Regulatory Elements for NKAPL Gene

Proteins for NKAPL Gene

  • Protein details for NKAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5M9Q1-NKAPL_HUMAN
    Recommended name:
    NKAP-like protein
    Protein Accession:
    Q5M9Q1
    Secondary Accessions:
    • Q3MIV1
    • Q9H4Q7

    Protein attributes for NKAPL Gene

    Size:
    402 amino acids
    Molecular mass:
    46312 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKAPL Gene

Proteomics data for NKAPL Gene at MOPED

Post-translational modifications for NKAPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKAPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKAPL Gene

Domains for NKAPL Gene

Protein Domains for NKAPL Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NKAPL_HUMAN
Family:
  • Belongs to the UPF0396 family.:
    • Q5M9Q1
genes like me logo Genes that share domains with NKAPL: view

No data available for Gene Families for NKAPL Gene

Function for NKAPL Gene

Phenotypes for NKAPL Gene

GenomeRNAi human phenotypes for NKAPL:
genes like me logo Genes that share phenotypes with NKAPL: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NKAPL Gene

Localization for NKAPL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKAPL Gene COMPARTMENTS Subcellular localization image for NKAPL gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for NKAPL Gene

Pathways for NKAPL Gene

SuperPathways for NKAPL Gene

No Data Available

Interacting Proteins for NKAPL Gene

Gene Ontology (GO) - Biological Process for NKAPL Gene

None

No data available for Pathways by source for NKAPL Gene

Transcripts for NKAPL Gene

mRNA/cDNA for NKAPL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKAPL Gene

NFKB activating protein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKAPL Gene

No ASD Table

Relevant External Links for NKAPL Gene

GeneLoc Exon Structure for
NKAPL
ECgene alternative splicing isoforms for
NKAPL

Expression for NKAPL Gene

mRNA expression in normal human tissues for NKAPL Gene

mRNA differential expression in normal tissues according to GTEx for NKAPL Gene

This gene is overexpressed in Testis (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NKAPL Gene

SOURCE GeneReport for Unigene cluster for NKAPL Gene Hs.48787

genes like me logo Genes that share expressions with NKAPL: view

Orthologs for NKAPL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NKAPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKAPL 36
  • 93.98 (n)
  • 92.23 (a)
NKAPL 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKAPL 37
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKAPL 36
  • 74.23 (n)
  • 68.08 (a)
NKAPL 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkapl 36
  • 72.52 (n)
  • 65.39 (a)
Nkapl 16
Nkapl 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 55 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nkapl 36
  • 71.1 (n)
  • 65.16 (a)
chicken
(Gallus gallus)
Aves NKAP 36
  • 64.74 (n)
  • 63.53 (a)
NKAP 37
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nkap 37
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6066 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-504 37
  • 24 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4484 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
Species with no ortholog for NKAPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKAPL Gene

ENSEMBL:
Gene Tree for NKAPL (if available)
TreeFam:
Gene Tree for NKAPL (if available)

Paralogs for NKAPL Gene

Paralogs for NKAPL Gene

Selected SIMAP similar genes for NKAPL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKAPL: view

Variants for NKAPL Gene

Sequence variations from dbSNP and Humsavar for NKAPL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1679705 -- 28,261,418(-) CAAGA(A/C)TCCAT downstream-variant-500B
rs139995613 -- 28,261,361(+) TTGTT(G/T)CTTAG downstream-variant-500B
rs145825413 -- 28,261,450(+) GGGCA(A/G)GGGGG downstream-variant-500B
rs149842202 -- 28,261,420(+) GGATT(C/T)TTGAA downstream-variant-500B
rs375070815 -- 28,261,352(+) AAACA(A/G)GTGTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NKAPL Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV Loss 17160897

Relevant External Links for NKAPL Gene

HapMap Linkage Disequilibrium report
NKAPL

Disorders for NKAPL Gene

Relevant External Links for NKAPL

Genetic Association Database (GAD)
NKAPL
genes like me logo Genes that share disorders with NKAPL: view

No data available for UniProtKB/Swiss-Prot for NKAPL Gene

Publications for NKAPL Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue W.H. … Zhang D. (Nat. Genet. 2011) 3 49
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  5. Identification of the NF-I_B activating protein-like locus as a risk locus for rheumatoid arthritis. (PMID: 23223422) Xie G. … Siminovitch K.A. (Ann. Rheum. Dis. 2013) 3

Products for NKAPL Gene

Sources for NKAPL Gene

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