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Aliases for NKAPL Gene

Aliases for NKAPL Gene

  • NFKB Activating Protein Like 2 3 5
  • C6orf194 3 4
  • Chromosome 6 Open Reading Frame 194 2
  • NFKB Activating Protein-Like 2
  • NKAP-Like Protein 3
  • BA424I5.1 3

External Ids for NKAPL Gene

Previous HGNC Symbols for NKAPL Gene

  • C6orf194

Previous GeneCards Identifiers for NKAPL Gene

  • GC06P028336
  • GC06P028227
  • GC06P028037

Summaries for NKAPL Gene

GeneCards Summary for NKAPL Gene

NKAPL (NFKB Activating Protein Like) is a Protein Coding gene. An important paralog of this gene is NKAP.

UniProtKB/Swiss-Prot for NKAPL Gene

  • Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAPL Gene

Genomics for NKAPL Gene

Regulatory Elements for NKAPL Gene

Enhancers for NKAPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G028211 1.4 Ensembl ENCODE 15.5 -46.8 -46763 2.2 CREB3L1 FEZF1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D SSRP1 ZNF610 RCOR2 ZNF603P ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN31 NKAPL ZSCAN9 PGBD1 ZSCAN16 ZSCAN12
GH06G028224 1.2 ENCODE 15.1 -34.0 -33979 2.1 PKNOX1 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF603P ZKSCAN4 ZKSCAN3 ZNF192P1 NKAPL ZKSCAN8 ZSCAN31 TRIM27 ZSCAN9 HIST1H4K
GH06G028334 1.4 ENCODE dbSUPER 10.9 +77.0 77005 4.0 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 MEF2D SSRP1 ZKSCAN4 ZNF603P ZSCAN23 ZSCAN31 ZKSCAN3 NKAPL ZKSCAN8 TRIM27 OR2B7P ZNF391
GH06G028382 1.4 Ensembl ENCODE 10.7 +124.1 124103 1.9 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ZNF603P ZSCAN31 ZKSCAN3 ZKSCAN4 NKAPL ZSCAN16 ZNF165 ZSCAN12
GH06G028141 1.4 ENCODE dbSUPER 10.6 -117.0 -117009 2.2 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 ZFP41 MEF2D SSRP1 ZNF603P ZKSCAN3 ZKSCAN4 ZSCAN23 NKAPL ZSCAN31 ZNF391 ZSCAN12 OR2B7P TRIM27
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NKAPL on UCSC Golden Path with GeneCards custom track

Promoters for NKAPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195210 -197 601 HDAC1 MAX CEBPG ATF2 GABPA JUND POLR2A ATF3 EGR1 EED

Genomic Location for NKAPL Gene

Chromosome:
6
Start:
28,259,297 bp from pter
End:
28,260,958 bp from pter
Size:
1,662 bases
Orientation:
Plus strand

Genomic View for NKAPL Gene

Genes around NKAPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAPL Gene

Proteins for NKAPL Gene

  • Protein details for NKAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5M9Q1-NKAPL_HUMAN
    Recommended name:
    NKAP-like protein
    Protein Accession:
    Q5M9Q1
    Secondary Accessions:
    • Q3MIV1
    • Q9H4Q7

    Protein attributes for NKAPL Gene

    Size:
    402 amino acids
    Molecular mass:
    46312 Da
    Quaternary structure:
    • Interacts with RBPJ, CIR1 and HDAC3.

neXtProt entry for NKAPL Gene

Post-translational modifications for NKAPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKAPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKAPL Gene

Domains & Families for NKAPL Gene

Protein Domains for NKAPL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKAPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5M9Q1

UniProtKB/Swiss-Prot:

NKAPL_HUMAN :
  • Belongs to the NKAP family.
Family:
  • Belongs to the NKAP family.
genes like me logo Genes that share domains with NKAPL: view

No data available for Gene Families for NKAPL Gene

Function for NKAPL Gene

Molecular function for NKAPL Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.

Gene Ontology (GO) - Molecular Function for NKAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with NKAPL: view
genes like me logo Genes that share phenotypes with NKAPL: view

Animal Models for NKAPL Gene

MGI Knock Outs for NKAPL:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKAPL Gene

Localization for NKAPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAPL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKAPL gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NKAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NKAPL: view

Pathways & Interactions for NKAPL Gene

SuperPathways for NKAPL Gene

No Data Available

Interacting Proteins for NKAPL Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345716%0d%0a9606.ENSP00000346088%0d%0a9606.ENSP00000346080%0d%0a9606.ENSP00000261973%0d%0a9606.ENSP00000339723%0d%0a9606.ENSP00000265073%0d%0a
Selected Interacting proteins: Q5M9Q1-NKAPL_HUMAN ENSP00000345716 for NKAPL Gene via IID STRING

Gene Ontology (GO) - Biological Process for NKAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NKAPL: view

No data available for Pathways by source and SIGNOR curated interactions for NKAPL Gene

Drugs & Compounds for NKAPL Gene

No Compound Related Data Available

Transcripts for NKAPL Gene

mRNA/cDNA for NKAPL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKAPL Gene

NFKB activating protein-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKAPL Gene

No ASD Table

Relevant External Links for NKAPL Gene

GeneLoc Exon Structure for
NKAPL
ECgene alternative splicing isoforms for
NKAPL

Expression for NKAPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKAPL Gene

mRNA differential expression in normal tissues according to GTEx for NKAPL Gene

This gene is overexpressed in Testis (x13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NKAPL Gene



NURSA nuclear receptor signaling pathways regulating expression of NKAPL Gene:

NKAPL

SOURCE GeneReport for Unigene cluster for NKAPL Gene:

Hs.48787

Evidence on tissue expression from TISSUES for NKAPL Gene

  • Nervous system(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with NKAPL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKAPL Gene

Orthologs for NKAPL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NKAPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKAPL 34 35
  • 93.98 (n)
dog
(Canis familiaris)
Mammalia NKAPL 34 35
  • 74.23 (n)
mouse
(Mus musculus)
Mammalia Nkapl 34 16 35
  • 72.52 (n)
rat
(Rattus norvegicus)
Mammalia Nkapl 34
  • 71.1 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 64 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NKAPL 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves NKAP 34 35
  • 64.74 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nkap 35
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6066 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-504 35
  • 24 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4484 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for NKAPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKAPL Gene

ENSEMBL:
Gene Tree for NKAPL (if available)
TreeFam:
Gene Tree for NKAPL (if available)

Paralogs for NKAPL Gene

Paralogs for NKAPL Gene

(1) SIMAP similar genes for NKAPL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKAPL: view

Variants for NKAPL Gene

Sequence variations from dbSNP and Humsavar for NKAPL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001245941 -- 28,257,706(+) TTACT(A/G)TTGGC intron-variant, upstream-variant-2KB
rs1001676006 -- 28,258,016(+) ATTCA(C/T)ATATA intron-variant, upstream-variant-2KB
rs1002705275 -- 28,260,800(+) GGAGA(A/G)TTAGT upstream-variant-2KB, utr-variant-3-prime
rs1003970067 -- 28,259,258(+) GGTAA(C/T)TGACA upstream-variant-2KB, utr-variant-5-prime
rs1005643066 -- 28,261,150(+) GGCTT(G/T)CTTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NKAPL Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV loss 17160897
nsv950146 CNV duplication 24416366

Variation tolerance for NKAPL Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKAPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKAPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAPL Gene

Disorders for NKAPL Gene

Relevant External Links for NKAPL

Genetic Association Database (GAD)
NKAPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKAPL

No disorders were found for NKAPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAPL Gene

Publications for NKAPL Gene

  1. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue W.H. … Zhang D. (Nat. Genet. 2011) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. Further evidence supporting the association of NKAPL with schizophrenia. (PMID: 26297123) Wang Z. … Zhang F. (Neurosci. Lett. 2015) 3 64
  5. A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis. (PMID: 25875095) Okuda H. … Tanaka H. (PLoS ONE 2015) 3 64

Products for NKAPL Gene

Sources for NKAPL Gene

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