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NKAPL Gene

protein-coding   GIFtS: 45
GCID: GC06P028227

NFKB Activating Protein-Like

(Previous name: chromosome 6 open reading frame 194)
(Previous symbol: C6orf194)
  Search for NKAPL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NFKB Activating Protein-Like1 2
C6orf1941 2 3
Chromosome 6 Open Reading Frame 1941
bA424I5.12
NKAP-Like Protein2

External Ids:    HGNC: 215841   Entrez Gene: 2226982   Ensembl: ENSG000001891347   UniProtKB: Q5M9Q13   

Export aliases for NKAPL gene to outside databases

Previous GC identifers: GC06P028336 GC06P028037


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NKAPL Gene:
NKAPL (NFKB activating protein-like) is a protein-coding gene. An important paralog of this gene is NKAP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKAPL gene promoter:
         p53   GR-beta   Brachyury   p300   LCR-F1   Roaz   c-Ets-1   GATA-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKAPL promoter sequence
   Search Chromatin IP Primers for NKAPL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKAPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.33

NKAPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKAPL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P028227:  view genomic region     (about GC identifiers)

Start:
28,227,098 bp from pter      End:
28,228,736 bp from pter
Size:
1,639 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NKAPL_HUMAN, Q5M9Q1 (See protein sequence)
Recommended Name: NKAP-like protein  
Size: 402 amino acids; 46312 Da
Secondary accessions: Q3MIV1 Q9H4Q7

Explore the universe of human proteins at neXtProt for NKAPL: NX_Q5M9Q1

Explore proteomics data for NKAPL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NKAPL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001007532.1  
    ENSEMBL proteins: 
     ENSP00000345716  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009269 DUF926

    Graphical View of Domain Structure for InterPro Entry Q5M9Q1

    ProtoNet protein and cluster: Q5M9Q1

    UniProtKB/Swiss-Prot: NKAPL_HUMAN, Q5M9Q1
    Similarity: Belongs to the UPF0396 family


    Find genes that share domains with NKAPL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for NKAPL:
     Increased cell number in G1, a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKAPL
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    hsa-miR-370 hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidNKAPL 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAPL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKAPL
    Interactions:

        Search GeneGlobe Interaction Network for NKAPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for NKAPL (ENSP000003457164) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM25ENSP000002619734STRING: ENSP00000261973
    SNRNP70ENSP000002214484STRING: ENSP00000221448
    SUB1ENSP000002650734STRING: ENSP00000265073
    SNRNP35ENSP000004033104STRING: ENSP00000403310
    PNISRENSP000003582424STRING: ENSP00000358242
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NKAPL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NKAPL gene: 
    NM_001007531.2  

    Unigene Cluster for NKAPL:

    NFKB activating protein-like
    Hs.48787  [show with all ESTs]
    Unigene Representative Sequence: NM_001007531
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343684(uc003nkt.3)
    miRNA
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    hsa-miR-370 hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidNKAPL 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat NKAPL

    Additional mRNA sequence: 

    AF085870.1 BC038240.1 BC101681.1 BC101685.1 

    3 DOTS entries:

    DT.210052  DT.40113131  DT.97812596 

    Selected AceView cDNA sequences (see all 50):

    AA953780 AF085870 AI825371 AI240405 AI183972 AA426031 AA889640 BF222720 
    AA719187 AI825424 AW003978 AW515746 AA902654 AI970107 BV189541 AW196436 
    AA913827 BQ186305 BX115857 AA868841 CD251377 AW207887 AI633740 BC038240 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NKAPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTAAAAA
    NKAPL Expression
    About this image

    NKAPL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NKAPL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48787
        Custom PCR Arrays for NKAPL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAPL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NKAPL gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkapl1 , 5 NFKB activating protein-like1, 5 72.52(n)1
    65.39(a)1
      13 (7.81 cM)5
    667071  NM_025719.31  NP_079995.21 
     214670475 
    chicken
    (Gallus gallus)
    Aves NKAP1 NFKB activating protein 64.74(n)
    63.53(a)
      422368  NM_001006437.1  NP_001006437.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    58(a)
    1 → many
    GL343950.1(64924-73433)
    zebrafish
    (Danio rerio)
    Actinopterygii nkap6
    NFKB activating protein
    50(a)
    1 → many
    14(34393486-34400219) ENSDARG00000033450
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60666
    --
    30(a)
    1 → many
    3R(22940953-22942398)
    worm
    (Caenorhabditis elegans)
    Secernentea let-5046
    Protein LET-504 (let-504) mRNA, complete cds
    24(a)
    1 → many
    I(4129564-4132292) WBGene00002696
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.44842 Vitis vinifera transcribed sequence with weak similarity more 71.48(n)    CB972234.1 


    ENSEMBL Gene Tree for NKAPL (if available)
    TreeFam Gene Tree for NKAPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NKAPL gene
    NKAP2  
    1 SIMAP similar gene for NKAPL using alignment to 1 protein entry:     NKAPL_HUMAN:
    NKAP

    Find genes that share paralogs with NKAPL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NKAPL (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105374721,2
    C--28034203(+) tctcc-/A/AA  
            
    aaaaa
    1 -- us2k11NA 2
    rs1887870861,2
    --28225100(+) CTCATA/CAGTGG 1 -- us2k10--------
    rs1456957801,2
    --28225113(+) GTTTAA/CCAATG 1 -- us2k10--------
    rs12255891,2
    C--28225136(+) cacagG/Cgagtg 1 -- us2k17Minor allele frequency- C:0.00NA WA CSA 13
    rs1492040201,2
    --28225296(+) TGCATA/GTTCTA 1 -- us2k10--------
    rs1910816851,2
    --28225302(+) TTCTAA/CACATG 1 -- us2k10--------
    rs132080961,2
    C,F,H--28225311(+) TGTATC/GCCAGA 1 -- us2k18Minor allele frequency- G:0.04NS EA NA 524
    rs2013728601,2
    --28225332(+) AAATT-/AAAAAA 1 -- us2k10--------
    rs1828264801,2
    --28225463(+) GGCCCA/GCAAAG 1 -- us2k10--------
    rs1872220511,2
    --28225515(+) CAGCCC/TCTAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NKAPL (28227098 - 28228736 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NKAPL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830620CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NKAPL
    DNA2.0 Custom Variant and Variant Library Synthesis for NKAPL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with NKAPL           About GenesLikeMe

    Genetic Association Database (GAD): NKAPL

    Export disorders for NKAPL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NKAPL gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NKAPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PubMed id 22037552)1, 4 Yue W.H....Zhang D. (Nat. Genet. 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    5. Identification of the NF-I_B activating protein-like locus as a risk locus for rheumatoid arthritis. (PubMed id 23223422)1 Xie G....Siminovitch K.A. (Ann. Rheum. Dis. 2013)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 222698 HGNC: 21584 AceView: C6orf194 Ensembl:ENSG00000189134 euGenes: HUgn222698
    ECgene: NKAPL H-InvDB: NKAPL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NKAPL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NKAPL gene:
    Search GeneIP for patents involving NKAPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for NKAPL Search Chromatin IP Primers for NKAPL
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKAPL
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     Search Addgene for plasmids for NKAPL
      Search eBioscience for proteins for NKAPL
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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