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Aliases for NKAPL Gene

Aliases for NKAPL Gene

  • NFKB Activating Protein Like 2 3 5
  • C6orf194 3 4
  • Chromosome 6 Open Reading Frame 194 2
  • NFKB Activating Protein-Like 2
  • NKAP-Like Protein 3
  • BA424I5.1 3

External Ids for NKAPL Gene

Previous HGNC Symbols for NKAPL Gene

  • C6orf194

Previous GeneCards Identifiers for NKAPL Gene

  • GC06P028336
  • GC06P028227
  • GC06P028037

Summaries for NKAPL Gene

GeneCards Summary for NKAPL Gene

NKAPL (NFKB Activating Protein Like) is a Protein Coding gene. An important paralog of this gene is NKAP.

UniProtKB/Swiss-Prot for NKAPL Gene

  • Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.

Additional gene information for NKAPL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAPL Gene

Genomics for NKAPL Gene

GeneHancer (GH) Regulatory Elements for NKAPL Gene

Promoters and enhancers for NKAPL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I028258 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 -0.1 -52 0.9 MAX GABPA POLR2A IKZF1 ZBTB33 ETV6 IKZF2 SPI1 NKAPL ZKSCAN4 ZNF603P ZNF192P1 ZSCAN31 LOC102724889 ZNF391 TOB2P1
GH06I028224 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.1 -34.0 -33968 2.1 MLX ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D SSRP1 ZSCAN9 ZNF603P ZKSCAN4 ZKSCAN3 ZKSCAN8 ZNF192P1 NKAPL ZSCAN12 ZSCAN31 TRIM27
GH06I028334 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.9 +77.0 77004 4 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 SP3 NFYC MEF2D SSRP1 NBN ZSCAN31 ZKSCAN4 ZNF603P ZSCAN23 ZKSCAN3 NKAPL ZKSCAN8 TRIM27 OR2B7P ZNF391
GH06I028141 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 -117.0 -117010 2.2 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZKSCAN8 ZNF603P ZKSCAN3 ZKSCAN4 ZSCAN12 ZNF391 ZSCAN23 ZSCAN9 ZNF204P ZNF184
GH06I028281 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.9 +22.6 22604 1.4 ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF213 ZNF143 SP3 SP5 NFYC PGBD1 PIR51235 GC06P028283 ZKSCAN3 ZKSCAN4 ZNF603P ZKSCAN8 ZSCAN12 ZSCAN9 NKAPL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NKAPL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NKAPL gene promoter:

Genomic Locations for NKAPL Gene

Genomic Locations for NKAPL Gene
1,662 bases
Plus strand

Genomic View for NKAPL Gene

Genes around NKAPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAPL Gene

Proteins for NKAPL Gene

  • Protein details for NKAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NKAP-like protein
    Protein Accession:
    Secondary Accessions:
    • Q3MIV1
    • Q9H4Q7

    Protein attributes for NKAPL Gene

    402 amino acids
    Molecular mass:
    46312 Da
    Quaternary structure:
    • Interacts with RBPJ, CIR1 and HDAC3.

neXtProt entry for NKAPL Gene

Post-translational modifications for NKAPL Gene

No Post-translational modifications

Other Protein References for NKAPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKAPL Gene

Domains & Families for NKAPL Gene

Gene Families for NKAPL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NKAPL Gene


Suggested Antigen Peptide Sequences for NKAPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NKAP family.
  • Belongs to the NKAP family.
genes like me logo Genes that share domains with NKAPL: view

Function for NKAPL Gene

Molecular function for NKAPL Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.

Phenotypes From GWAS Catalog for NKAPL Gene

Gene Ontology (GO) - Molecular Function for NKAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with NKAPL: view
genes like me logo Genes that share phenotypes with NKAPL: view

Animal Models for NKAPL Gene

MGI Knock Outs for NKAPL:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKAPL Gene

Localization for NKAPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAPL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKAPL gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NKAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NKAPL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NKAPL Gene

Pathways & Interactions for NKAPL Gene

SuperPathways for NKAPL Gene

No Data Available

Interacting Proteins for NKAPL Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)
Selected Interacting proteins: ENSP00000345716 Q5M9Q1-NKAPL_HUMAN for NKAPL Gene via STRING IID

Gene Ontology (GO) - Biological Process for NKAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NKAPL: view

No data available for Pathways by source and SIGNOR curated interactions for NKAPL Gene

Drugs & Compounds for NKAPL Gene

No Compound Related Data Available

Transcripts for NKAPL Gene

mRNA/cDNA for NKAPL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKAPL Gene

NFKB activating protein-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKAPL Gene

No ASD Table

Relevant External Links for NKAPL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKAPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKAPL Gene

mRNA differential expression in normal tissues according to GTEx for NKAPL Gene

This gene is overexpressed in Testis (x13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NKAPL Gene

NURSA nuclear receptor signaling pathways regulating expression of NKAPL Gene:


SOURCE GeneReport for Unigene cluster for NKAPL Gene:


Evidence on tissue expression from TISSUES for NKAPL Gene

  • Nervous system(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with NKAPL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKAPL Gene

Orthologs for NKAPL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NKAPL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NKAPL 33 34
  • 93.98 (n)
(Canis familiaris)
Mammalia NKAPL 33 34
  • 74.23 (n)
(Mus musculus)
Mammalia Nkapl 33 16 34
  • 72.52 (n)
(Rattus norvegicus)
Mammalia Nkapl 33
  • 71.1 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 64 (a)
(Bos Taurus)
Mammalia NKAPL 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
(Gallus gallus)
Aves NKAP 33 34
  • 64.74 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 58 (a)
(Danio rerio)
Actinopterygii nkap 34
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6066 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea let-504 34
  • 24 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4484 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for NKAPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKAPL Gene

Gene Tree for NKAPL (if available)
Gene Tree for NKAPL (if available)

Paralogs for NKAPL Gene

Paralogs for NKAPL Gene

(1) SIMAP similar genes for NKAPL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKAPL: view

Variants for NKAPL Gene

Sequence variations from dbSNP and Humsavar for NKAPL Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001245941 -- 28,257,706(+) A/G upstream_transcript_variant
rs1001676006 -- 28,258,016(+) C/T upstream_transcript_variant
rs1002705275 -- 28,260,800(+) G/A 3_prime_UTR_variant
rs1003970067 -- 28,259,258(+) C/T upstream_transcript_variant
rs1005643066 -- 28,261,150(+) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NKAPL Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV loss 17160897
nsv950146 CNV duplication 24416366

Variation tolerance for NKAPL Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKAPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAPL Gene

Disorders for NKAPL Gene

Additional Disease Information for NKAPL

No disorders were found for NKAPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAPL Gene

Publications for NKAPL Gene

  1. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue WH … Zhang D (Nature genetics 2011) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese. (PMID: 28095483) Wu S … Ko YL (PloS one 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for NKAPL Gene

Sources for NKAPL Gene

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