NKAPL Gene
protein-coding GIFtS: 43
GCID: GC06P028227
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NFKB activating protein-like(Previous name: chromosome 6 open reading frame 194 )
(Previous symbol: C6orf194)
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Aliases
for NKAPL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NFKB Activating Protein-Like1 2 | | C6orf1941 2 3 | | BA424I5.11 | | Chromosome 6 Open Reading Frame 1941 | | NKAP-Like Protein2 |
Export aliases for NKAPL gene to outside databasesPrevious GC identifers: GC06P028336 GC06P028037 |
Summaries
for NKAPL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NKAPL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NKAPL gene promoter:
p53 GR-beta Brachyury p300 LCR-F1 Roaz c-Ets-1 GATA-1 AREB6 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for NKAPL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKAPL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p21.33NKAPL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P028227: view genomic region
(about GC identifiers)
Start:
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28,227,098 bp from pter |
End:
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28,228,736 bp from pter |
Size:
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1,639 bases |
Orientation:
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plus strand |
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Proteins
for NKAPL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NKAPL_HUMAN, Q5M9Q1 (See
protein sequence)Recommended Name: NKAP-like protein Size: 402 amino acids; 46312 Da
Secondary accessions: Q3MIV1 Q9H4Q7Explore the universe of human proteins at neXtProt for NKAPL: NX_Q5M9Q1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5M9Q1
NKAPL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001007532.1
ENSEMBL proteins: ENSP00000345716
Human Recombinant Protein Products:
NKAPL Antibody Products:
Assay Products for NKAPL: |
Protein
Domains /
Families
for NKAPL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NKAPL for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5M9Q1ProtoNet protein and cluster: Q5M9Q1 UniProtKB/Swiss-Prot: NKAPL_HUMAN, Q5M9Q1Similarity: Belongs to the UPF0396 family |
Function
for NKAPL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKAPL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKAPL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NKAPL (NM_001007531) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NKAPL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKAPL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAPL |
1 GenomeRNAi human phenotype for NKAPL:
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Pathways & Interactions
for NKAPL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKAPL
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for NKAPL (ENSP000003457164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for NKAPL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NKAPL
Search CenterWatch for drugs/clinical trials and news about NKAPL
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Transcripts
for NKAPL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NKAPL gene: NM_001007531.2 Unigene Cluster for NKAPL: NFKB activating protein-like Hs.239181 [show with all ESTs]Unigene Representative Sequence: NM_0010075311 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000343684(uc003nkt.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKAPL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKAPL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NKAPL (NM_001007531) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NKAPL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKAPL |
Additional cDNA sequence: AF085870.1 BC038240.1 BC101681.1 BC101685.1 1 DOTS entry: DT.210052 24/50 AceView cDNA sequences (see all 50): AF085870 AI183972 AA953780 AI240405 AI825371 BQ186305 AI989981 AW207887 W70126 BQ186490 AA902654 AW515746 AI825424 AI633740 CD251377 AA364992 AI970107 AA426031 BF222720 AA719187 AI129164 AA868841 BX115857 AW072534
GeneLoc Exon Structure
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Expression
for NKAPL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NKAPL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTTAAAAA
About this image
See NKAPL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NKAPL
SOURCE GeneReport for Unigene cluster: Hs.239181
SABiosciences Custom PCR Arrays for NKAPL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NKAPL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NKAPL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKAPL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKAPL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAPL |
Orthologs
for NKAPL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for NKAPL gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NKAP6 |
nuclear NF-kappaB activating protein |
68(a) |
1 → many |
4(16614499-16618896) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
59(a) |
1 → many |
GL343950.1(64924-71067) |
zebrafish
(Danio rerio) |
Actinopterygii |
nkap6 |
NFKB activating protein |
57(a) |
1 → many |
14(34393486-34400219) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG60666 |
-- |
30(a) |
1 → many |
3R(22940953-22942398) |
worm
(Caenorhabditis elegans) |
Secernentea |
E01A2.46 |
Protein E01A2.4 |
19(a) |
1 → many |
I(4129566-4132294) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G027206 |
uncharacterized protein |
25(a) |
1 → many |
4(1204303-1205866) |
rice
(Oryza sativa) |
Liliopsida |
---- |
NFKB, putative, expressed |
26(a)22(a) |
many ↔ manymany ↔ many |
8(23204143-23205193) 9(17140365-17142324) |
ENSEMBL Gene Tree for NKAPL (if available)
TreeFam Gene Tree for NKAPL (if available) |
Paralogs
for NKAPL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NKAPL gene
- NKAP2
1 SIMAP similar gene for NKAPL using alignment to 1 protein entry: NKAPL_HUMAN:NKAP
NKAPL for paralogs About GeneDecksing
|
Genomic Variants
for NKAPL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NKAPL (28227098 - 28228736 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NKAPL
1 CNV: 4491 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKAPL |
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Disorders
/ Diseases
for NKAPL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NKAPL for disorders About GeneDecksing
2  diseases for NKAPL: About MalaCardsschizophrenia malaria
Export disorders for NKAPL gene to outside databases
|
Publications
for NKAPL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NKAPL gene integrated from 9 sources:
(articles sorted by number of sources associating them with NKAPL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Genome-wide association study identifies a susceptibi lity locus for schizophrenia in Han Chinese at 11p11.2. (PubMed id 22037552)1 Yue W.H....Zhang D. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NKAPL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NKAPL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NKAPL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NKAPL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NKAPL | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NKAPL gene:
Search GeneIP for patents involving NKAPL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NKAPL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NKAPL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NKAPL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NKAPL | | | OriGene Protein Over-expression Lysate for NKAPL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NKAPL | | OriGene 3'-UTR Clone for NKAPL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NKAPL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NKAPL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NKAPL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NKAPL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKAPL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NKAPL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NKAPL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NKAPL |
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| | | | Search Tocris compounds for NKAPL |
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 | | | NKAPL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAPL |
|  |  |  | | | | ThermoFisher Antibodies for NKAPL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKAPL |
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