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Aliases for NKAPL Gene

Aliases for NKAPL Gene

  • NFKB Activating Protein Like 2 3 5
  • NFKB Activating Protein-Like 2 3
  • C6orf194 3 4
  • Chromosome 6 Open Reading Frame 194 2
  • BA424I5.1 3

External Ids for NKAPL Gene

Previous HGNC Symbols for NKAPL Gene

  • C6orf194

Previous GeneCards Identifiers for NKAPL Gene

  • GC06P028336
  • GC06P028037

Summaries for NKAPL Gene

GeneCards Summary for NKAPL Gene

NKAPL (NFKB Activating Protein Like) is a Protein Coding gene. An important paralog of this gene is NKAP.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAPL Gene

Genomics for NKAPL Gene

Regulatory Elements for NKAPL Gene

Enhancers for NKAPL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NKAPL on UCSC Golden Path with GeneCards custom track

Promoters for NKAPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NKAPL on UCSC Golden Path with GeneCards custom track

Genomic Location for NKAPL Gene

Chromosome:
6
Start:
28,259,297 bp from pter
End:
28,260,958 bp from pter
Size:
1,662 bases
Orientation:
Plus strand

Genomic View for NKAPL Gene

Genes around NKAPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAPL Gene

Proteins for NKAPL Gene

  • Protein details for NKAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5M9Q1-NKAPL_HUMAN
    Recommended name:
    NKAP-like protein
    Protein Accession:
    Q5M9Q1
    Secondary Accessions:
    • Q3MIV1
    • Q9H4Q7

    Protein attributes for NKAPL Gene

    Size:
    402 amino acids
    Molecular mass:
    46312 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKAPL Gene

Proteomics data for NKAPL Gene at MOPED

Post-translational modifications for NKAPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKAPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKAPL Gene

Domains & Families for NKAPL Gene

Protein Domains for NKAPL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKAPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5M9Q1

UniProtKB/Swiss-Prot:

NKAPL_HUMAN :
  • Belongs to the UPF0396 family.
Family:
  • Belongs to the UPF0396 family.
genes like me logo Genes that share domains with NKAPL: view

No data available for Gene Families for NKAPL Gene

Function for NKAPL Gene

Phenotypes for NKAPL Gene

genes like me logo Genes that share phenotypes with NKAPL: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKAPL Gene

Localization for NKAPL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKAPL Gene COMPARTMENTS Subcellular localization image for NKAPL gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NKAPL Gene

Pathways & Interactions for NKAPL Gene

SuperPathways for NKAPL Gene

No Data Available

Interacting Proteins for NKAPL Gene

Gene Ontology (GO) - Biological Process for NKAPL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NKAPL Gene

Drugs & Compounds for NKAPL Gene

No Compound Related Data Available

Transcripts for NKAPL Gene

mRNA/cDNA for NKAPL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NKAPL Gene

NFKB activating protein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKAPL Gene

No ASD Table

Relevant External Links for NKAPL Gene

GeneLoc Exon Structure for
NKAPL
ECgene alternative splicing isoforms for
NKAPL

Expression for NKAPL Gene

mRNA expression in normal human tissues for NKAPL Gene

mRNA differential expression in normal tissues according to GTEx for NKAPL Gene

This gene is overexpressed in Testis (x13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NKAPL Gene



SOURCE GeneReport for Unigene cluster for NKAPL Gene Hs.48787

genes like me logo Genes that share expression patterns with NKAPL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NKAPL Gene

Orthologs for NKAPL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NKAPL Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NKAPL 35
  • 74.23 (n)
  • 68.08 (a)
NKAPL 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkapl 35
  • 72.52 (n)
  • 65.39 (a)
Nkapl 16
Nkapl 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NKAPL 35
  • 93.98 (n)
  • 92.23 (a)
NKAPL 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkapl 35
  • 71.1 (n)
  • 65.16 (a)
cow
(Bos Taurus)
Mammalia NKAPL 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves NKAP 35
  • 64.74 (n)
  • 63.53 (a)
NKAP 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nkap 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6066 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-504 36
  • 24 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4484 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for NKAPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKAPL Gene

ENSEMBL:
Gene Tree for NKAPL (if available)
TreeFam:
Gene Tree for NKAPL (if available)

Paralogs for NKAPL Gene

Paralogs for NKAPL Gene

(1) SIMAP similar genes for NKAPL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKAPL: view

Variants for NKAPL Gene

Sequence variations from dbSNP and Humsavar for NKAPL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_028999 -
VAR_029000 -
VAR_029001 -
VAR_029002 -
rs1679705 -- 28,261,418(-) CAAGA(A/C)TCCAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NKAPL Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV Loss 17160897

Variation tolerance for NKAPL Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NKAPL Gene

Disorders for NKAPL Gene

Relevant External Links for NKAPL

Genetic Association Database (GAD)
NKAPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKAPL

No disorders were found for NKAPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAPL Gene

Publications for NKAPL Gene

  1. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue W.H. … Zhang D. (Nat. Genet. 2011) 3 48 67
  2. A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis. (PMID: 25875095) Okuda H. … Tanaka H. (PLoS ONE 2015) 3
  3. Further evidence supporting the association of NKAPL with schizophrenia. (PMID: 26297123) Wang Z. … Zhang F. (Neurosci. Lett. 2015) 3
  4. Resequencing and association study of the NFKB activating protein-like gene (NKAPL) in schizophrenia. (PMID: 24972756) Chen S.F. … Weng C.F. (Schizophr. Res. 2014) 3
  5. Identification of the NF-I_B activating protein-like locus as a risk locus for rheumatoid arthritis. (PMID: 23223422) Xie G. … Siminovitch K.A. (Ann. Rheum. Dis. 2013) 3

Products for NKAPL Gene

Sources for NKAPL Gene

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