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Aliases for NKAPD1 Gene

Aliases for NKAPD1 Gene

  • NKAP Domain Containing 1 2 3
  • C11orf57 3 4 5
  • Chromosome 11 Open Reading Frame 57 2 5
  • Uncharacterized Protein C11orf57 3

External Ids for NKAPD1 Gene

Previous HGNC Symbols for NKAPD1 Gene

  • C11orf57

Summaries for NKAPD1 Gene

GeneCards Summary for NKAPD1 Gene

NKAPD1 (NKAP Domain Containing 1) is a Protein Coding gene.

Additional gene information for NKAPD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAPD1 Gene

Genomics for NKAPD1 Gene

Regulatory Elements for NKAPD1 Gene

Enhancers for NKAPD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H112320 1.5 Ensembl ENCODE dbSUPER 22.2 +247.5 247522 2 FOXA2 FEZF1 BRCA1 YY1 DEK YY2 TSHZ1 ZNF488 REST ZNF491 ALG9 NKAPD1 TTC12 ENSG00000254980 RNU2-60P LOC644277 RNU6-44P DIXDC1 GC11P112339 GC11M112270
GH11H111934 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -134.0 -134022 11 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PPP2R1B SDHD C11orf52 HSPB2 HSPB2-C11orf52 TIMM8B FDXACB1 C11orf1 ALG9 NKAPD1
GH11H111697 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -375.3 -375324 2 PKNOX1 ATF1 ARNT CHAMP1 TCF12 GATA2 SMARCA5 ZEB2 SMARCB1 ZNF592 PPP2R1B NKAPD1 BTG4 C11orf88 MIR34B MIR34C SIK2 RN7SKP273 PIR48599
GH11H112289 1.5 Ensembl ENCODE dbSUPER 9.3 +218.0 217957 4 ATF1 ARNT SIN3A FEZF1 GLIS2 ZNF143 ZNF207 KLF7 SP5 MXD4 LOC283140 RNU6-44P TEX12 NKAPD1 PIH1D2 BCO2 GC11M112270 GC11P112339
GH11H111764 1.3 ENCODE dbSUPER 10.6 -308.1 -308071 3 ZNF493 ARID4B SIN3A YY1 ZNF121 GLIS2 RUNX3 ZNF202 SP3 ZC3H11A ALG9 SIK2 PPP2R1B ENSG00000255334 PIH1D2 NKAPD1 LAYN BTG4 MIR34B MIR34C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NKAPD1 on UCSC Golden Path with GeneCards custom track

Promoters for NKAPD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044954 314 1601 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143

Genomic Location for NKAPD1 Gene

Chromosome:
11
Start:
112,074,086 bp from pter
End:
112,085,150 bp from pter
Size:
11,065 bases
Orientation:
Plus strand

Genomic View for NKAPD1 Gene

Genes around NKAPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAPD1 Gene

Proteins for NKAPD1 Gene

  • Protein details for NKAPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUT1-CK057_HUMAN
    Recommended name:
    Uncharacterized protein C11orf57
    Protein Accession:
    Q6ZUT1
    Secondary Accessions:
    • Q5RL41
    • Q6IN53
    • Q7Z357
    • Q8N2T3

    Protein attributes for NKAPD1 Gene

    Size:
    292 amino acids
    Molecular mass:
    34110 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NKAPD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKAPD1 Gene

Post-translational modifications for NKAPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NKAPD1 Gene

Domains & Families for NKAPD1 Gene

Gene Families for NKAPD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NKAPD1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NKAPD1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NKAPD1 Gene

Function for NKAPD1 Gene

Gene Ontology (GO) - Molecular Function for NKAPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NKAPD1: view

Phenotypes for NKAPD1 Gene

genes like me logo Genes that share phenotypes with NKAPD1: view

Animal Model Products

CRISPR Products

miRNA for NKAPD1 Gene

miRTarBase miRNAs that target NKAPD1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKAPD1 Gene

Localization for NKAPD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKAPD1 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NKAPD1 Gene

Pathways & Interactions for NKAPD1 Gene

SuperPathways for NKAPD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKAPD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NKAPD1 Gene

Drugs & Compounds for NKAPD1 Gene

No Compound Related Data Available

Transcripts for NKAPD1 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKAPD1 Gene

No ASD Table

Relevant External Links for NKAPD1 Gene

GeneLoc Exon Structure for
NKAPD1
ECgene alternative splicing isoforms for
NKAPD1

Expression for NKAPD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NKAPD1 Gene:

NKAPD1

Evidence on tissue expression from TISSUES for NKAPD1 Gene

  • Nervous system(3.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKAPD1 Gene

Orthologs for NKAPD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NKAPD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf57 33
  • 99.54 (n)
C11orf57 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf57 33
  • 93.41 (n)
MGC143285 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H11orf57 33
  • 92.61 (n)
C11orf57 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100151767 33
  • 86.03 (n)
mouse
(Mus musculus)
Mammalia AU019823 33 16 34
  • 85.16 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf57 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf57 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves C24H11ORF57 33
  • 67.13 (n)
C11orf57 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf57 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf57 33
  • 54.69 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1381 33
zebrafish
(Danio rerio)
Actinopterygii C15H11orf57 34
  • 42 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5815 33
Species where no ortholog for NKAPD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKAPD1 Gene

ENSEMBL:
Gene Tree for NKAPD1 (if available)
TreeFam:
Gene Tree for NKAPD1 (if available)

Paralogs for NKAPD1 Gene

No data available for Paralogs for NKAPD1 Gene

Variants for NKAPD1 Gene

Sequence variations from dbSNP and Humsavar for NKAPD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000001540 -- 112,080,290(+) TTTAA(A/G)CAGTA intron-variant
rs1000003560 -- 112,084,206(+) CTGGC(C/G)TTACT nc-transcript-variant, utr-variant-3-prime
rs1000436736 -- 112,083,974(+) CTATA(C/T)TGTGA nc-transcript-variant, utr-variant-3-prime
rs1000856537 -- 112,075,312(+) TGGTG(C/T)TCATG intron-variant, upstream-variant-2KB
rs1001036450 -- 112,079,058(+) CTCTT(A/T)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKAPD1 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV deletion 23290073

Variation tolerance for NKAPD1 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKAPD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKAPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAPD1 Gene

Disorders for NKAPD1 Gene

Relevant External Links for NKAPD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKAPD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKAPD1

No disorders were found for NKAPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAPD1 Gene

Publications for NKAPD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for NKAPD1 Gene

Sources for NKAPD1 Gene

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