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Aliases for NKAP Gene

Aliases for NKAP Gene

  • NFKB Activating Protein 2 3
  • NF KappaB Activating Protein 2

External Ids for NKAP Gene

Summaries for NKAP Gene

Entrez Gene Summary for NKAP Gene

  • This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]

GeneCards Summary for NKAP Gene

NKAP (NFKB Activating Protein) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathways. GO annotations related to this gene include chromatin binding and chromatin DNA binding. An important paralog of this gene is NKAPL.

UniProtKB/Swiss-Prot for NKAP Gene

  • Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.

Gene Wiki entry for NKAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAP Gene

Genomics for NKAP Gene

Genomic Location for NKAP Gene

Start:
119,925,050 bp from pter
End:
119,943,772 bp from pter
Size:
18,723 bases
Orientation:
Minus strand

Genomic View for NKAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NKAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAP Gene

Regulatory Elements for NKAP Gene

Proteins for NKAP Gene

  • Protein details for NKAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5F7-NKAP_HUMAN
    Recommended name:
    NF-kappa-B-activating protein
    Protein Accession:
    Q8N5F7
    Secondary Accessions:
    • Q6IPW6
    • Q96BQ2
    • Q9H638

    Protein attributes for NKAP Gene

    Size:
    415 amino acids
    Molecular mass:
    47138 Da
    Quaternary structure:
    • Component of the Notch corepressor complex. Interacts with CIR1 and HDAC3.
    SequenceCaution:
    • Sequence=AAH71686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for NKAP Gene

Proteomics data for NKAP Gene at MOPED

Post-translational modifications for NKAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKAP Gene

Domains for NKAP Gene

Protein Domains for NKAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKAP Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5F7

UniProtKB/Swiss-Prot:

NKAP_HUMAN
Family:
  • Belongs to the UPF0396 family.:
    • Q8N5F7
genes like me logo Genes that share domains with NKAP: view

No data available for Gene Families for NKAP Gene

Function for NKAP Gene

Molecular function for NKAP Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.

Gene Ontology (GO) - Molecular Function for NKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 19409814
GO:0005515 protein binding IPI 19409814
GO:0031490 chromatin DNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NKAP: view
genes like me logo Genes that share phenotypes with NKAP: view

miRNA for NKAP Gene

miRTarBase miRNAs that target NKAP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NKAP Gene

Localization for NKAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKAP Gene COMPARTMENTS Subcellular localization image for NKAP gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for NKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NKAP: view

Pathways for NKAP Gene

SuperPathways for NKAP Gene

Superpath Contained pathways
1 Notch Signaling Pathways
genes like me logo Genes that share pathways with NKAP: view

Pathways by source for NKAP Gene

1 R&D Systems pathway for NKAP Gene

Gene Ontology (GO) - Biological Process for NKAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0019827 stem cell maintenance IEA --
GO:0030097 hemopoiesis --
genes like me logo Genes that share ontologies with NKAP: view

Transcripts for NKAP Gene

mRNA/cDNA for NKAP Gene

Unigene Clusters for NKAP Gene

NFKB activating protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKAP Gene

No ASD Table

Relevant External Links for NKAP Gene

GeneLoc Exon Structure for
NKAP
ECgene alternative splicing isoforms for
NKAP

Expression for NKAP Gene

mRNA expression in normal human tissues for NKAP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NKAP Gene

SOURCE GeneReport for Unigene cluster for NKAP Gene Hs.522771

genes like me logo Genes that share expressions with NKAP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NKAP Gene

Orthologs for NKAP Gene

This gene was present in the common ancestor of animals.

Orthologs for NKAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKAP 35
  • 98.51 (n)
  • 98.62 (a)
NKAP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NKAP 35
  • 91.81 (n)
  • 93.49 (a)
NKAP 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKAP 35
  • 94.75 (n)
  • 97.95 (a)
NKAP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkap 35
  • 84.1 (n)
  • 86.92 (a)
Nkap 16
Nkap 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nkap 35
  • 83.13 (n)
  • 87.17 (a)
chicken
(Gallus gallus)
Aves NKAP 36
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia nuc06-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11365 35
zebrafish
(Danio rerio)
Actinopterygii nkap 36
  • 54 (a)
OneToMany
wufj36d09 35
fruit fly
(Drosophila melanogaster)
Insecta CG6066 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-504 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for NKAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKAP Gene

ENSEMBL:
Gene Tree for NKAP (if available)
TreeFam:
Gene Tree for NKAP (if available)

Paralogs for NKAP Gene

Paralogs for NKAP Gene

Selected SIMAP similar genes for NKAP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NKAP: view

Variants for NKAP Gene

Sequence variations from dbSNP and Humsavar for NKAP Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs181917 -- 119,945,184(+) tgcag(C/T)gagcc upstream-variant-2KB
rs194294 -- 119,924,811(+) CCTCT(C/T)GAGTA downstream-variant-500B
rs194295 -- 119,926,251(+) gcgcc(C/T)ggccT intron-variant
rs194296 -- 119,926,659(+) GGTGA(C/T)ATATC intron-variant
rs194297 -- 119,927,625(+) caggc(A/G)tgagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKAP Gene

Variant ID Type Subtype PubMed ID
dgv2468e1 CNV Complex 17122850
dgv2469e1 CNV Complex 17122850
nsv9969 CNV Gain 18304495
esv26416 CNV Gain 19812545
nsv7059 CNV Insertion 18451855
nsv425243 CNV Loss 16902084

Relevant External Links for NKAP Gene

HapMap Linkage Disequilibrium report
NKAP
Locus Specific Mutation Databases (LSDB)
NKAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAP Gene

Disorders for NKAP Gene

Relevant External Links for NKAP

Genetic Association Database (GAD)
NKAP
Human Genome Epidemiology (HuGE) Navigator
NKAP
genes like me logo Genes that share disorders with NKAP: view

No data available for UniProtKB/Swiss-Prot for NKAP Gene

Publications for NKAP Gene

  1. Identification of a nuclear protein that promotes NF-kappaB activation. (PMID: 14550261) Chen D. … Shu H.-B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Association of genetic profiles to Crohn's disease by linear combinations of single nucleotide polymorphisms. (PMID: 18804983) D'Addabbo A. … Ancona N. (Artif Intell Med 2009) 3 48

Products for NKAP Gene

Sources for NKAP Gene

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