Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NKAP Gene

protein-coding   GIFtS: 55
GCID: GC0XM119059

NFKB Activating Protein

  Search for NKAP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
NFKB Activating Protein1 2
NF KappaB Activating Protein1
NF-Kappa-B-Activating Protein2
NF-KappaB Activating Protein2

External Ids:    HGNC: 298731   Entrez Gene: 795762   Ensembl: ENSG000001018827   OMIM: 3007665   UniProtKB: Q8N5F73   

Export aliases for NKAP gene to outside databases

Previous GC identifers: GC0XM117813 GC0XM118840 GC0XM118943 GC0XM108555


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NKAP Gene:
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB.
This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it
thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell
development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy,
which has an intact CDS and may be functional, is located on chromosome 6. (provided by RefSeq, May 2010)

GeneCards Summary for NKAP Gene:
NKAP (NFKB activating protein) is a protein-coding gene. GO annotations related to this gene include chromatin DNA binding and chromatin binding. An important paralog of this gene is NKAPL.

UniProtKB/Swiss-Prot: NKAP_HUMAN, Q8N5F7
Function: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated
signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation.
Associates with chromatin at the Notch-regulated SKP2 promoter

Gene Wiki entry for NKAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKAP gene promoter:
         C/EBPbeta   p53   AP-1   ATF-2   GATA-1   MEF-2A   SRY   NRF-2   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNKAP promoter sequence
   Search Chromatin IP Primers for NKAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

NKAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKAP gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM119059:  view genomic region     (about GC identifiers)

Start:
119,059,013 bp from pter      End:
119,077,735 bp from pter
Size:
18,723 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NKAP_HUMAN, Q8N5F7 (See protein sequence)
Recommended Name: NF-kappa-B-activating protein  
Size: 415 amino acids; 47138 Da
Subunit: Component of the Notch corepressor complex. Interacts with CIR1 and HDAC3
Sequence caution: Sequence=AAH71686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q6IPW6 Q96BQ2 Q9H638

Explore the universe of human proteins at neXtProt for NKAP: NX_Q8N5F7

Explore proteomics data for NKAP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NKAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078804.2  
    ENSEMBL proteins: 
     ENSP00000360464  

    NKAP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NKAP
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NKAP
    GenScript Custom Purified and Recombinant Proteins Services for NKAP
    Novus Biologicals NKAP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NKAP

     
    Search eBioscience for Proteins for NKAP 

    NKAP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NKAP
    Novus Biologicals NKAP Antibodies
    Abcam antibodies for NKAP
    Cloud-Clone Corp. Antibodies for NKAP
    ThermoFisher Antibodies for NKAP
    LSBio Antibodies in human, mouse, rat for NKAP

    NKAP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NKAP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NKAP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NKAP
    Cloud-Clone Corp. CLIAs for NKAP
    Search eBioscience for ELISAs for NKAP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR009269 DUF926

    Graphical View of Domain Structure for InterPro Entry Q8N5F7

    ProtoNet protein and cluster: Q8N5F7

    UniProtKB/Swiss-Prot: NKAP_HUMAN, Q8N5F7
    Similarity: Belongs to the UPF0396 family


    Find genes that share domains with NKAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NKAP_HUMAN, Q8N5F7
    Function: Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated
    signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation.
    Associates with chromatin at the Notch-regulated SKP2 promoter

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA19409814
    GO:0005515protein binding IPI19409814
    GO:0031490chromatin DNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NKAP           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for NKAP:
     Cell division defect  Decreased viability of wild-ty  Increased G2M DNA content  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nkap):
     hematopoietic system  immune system 

    Find genes that share phenotypes with NKAP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKAP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NKAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NKAP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NKAP

    miRNA
    Products:
        
    miRTarBase miRNAs that target NKAP:
    hsa-mir-124-3p (MIRT022503), hsa-mir-186-5p (MIRT021176)

    Block miRNA regulation of human, mouse, rat NKAP using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NKAP:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidNKAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NKAP
    Predesigned siRNA for gene silencing in human, mouse, rat NKAP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NKAP

    Clone
    Products:
         
    OriGene clones in human, mouse for NKAP (see all 7)
    OriGene ORF clones in mouse, rat for NKAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NKAP (NM_024528)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKAP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NKAP
    Browse ESI BIO Cell Lines and PureStem Progenitors for NKAP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NKAP_HUMAN, Q8N5F7: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with NKAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NKAP About    
    See pathways by source

    SuperPathContained pathways About
    1Notch Signaling Pathways
    Notch Signaling Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NKAP
        Notch Signaling Pathways



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKAP
    Interactions:

        Search GeneGlobe Interaction Network for NKAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NKAP (Q8N5F71, 2, 3 ENSP000003604644) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX41Q9UJV91, 2, ENSP000003303494EBI-721539,EBI-1046350 MINT-8337673 MINT-8331403 STRING: ENSP00000330349
    RBMX2Q9Y3881, 2, ENSP000003390904EBI-721539,EBI-7704044 MINT-8331426 MINT-8337398 STRING: ENSP00000339090
    PRPF40AO754001, 2EBI-721539,EBI-473291 MINT-8333284 MINT-8331525
    DHX8Q145621, 2, ENSP000002624154EBI-721539,EBI-2511477 MINT-8337783 MINT-8331668 STRING: ENSP00000262415
    PRPF3O433951, 2, ENSP000003153794EBI-721539,EBI-744322 MINT-8336463 MINT-8331723 STRING: ENSP00000315379
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007219Notch signaling pathway IEA--
    GO:0019827stem cell maintenance IEA--
    GO:0030097hemopoiesis ----

    Find genes that share ontologies with NKAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NKAP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NKAP gene: 
    NM_024528.3  

    Unigene Cluster for NKAP:

    NFKB activating protein
    Hs.522771  [show with all ESTs]
    Unigene Representative Sequence: AY388958
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477789(uc004esg.3) ENST00000371410(uc004esh.3) ENST00000482407

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NKAP using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NKAP:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidNKAP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NKAP
    Predesigned siRNA for gene silencing in human, mouse, rat NKAP
    Clone
    Products:
         
    OriGene clones in human, mouse for NKAP (see all 7)
    OriGene ORF clones in mouse, rat for NKAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NKAP (NM_024528)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKAP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NKAP
    OriGene qSTAR qPCR primer pairs in human, mouse for NKAP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NKAP
      QuantiTect SYBR Green Assays in human, mouse, rat NKAP
      QuantiFast Probe-based Assays in human, mouse, rat NKAP

    Additional mRNA sequence: 

    AK026279.1 AL832118.1 AY388958.1 BC000940.2 BC012770.2 BC015354.1 BC016783.1 BC018968.1 
    BC032442.1 BC071686.1 

    8 DOTS entries:

    DT.442725  DT.100021929  DT.302983  DT.91642770  DT.95157264  DT.95157265  DT.102828750  DT.75187903 

    Selected AceView cDNA sequences (see all 138):

    BQ435950 AL517383 BF515591 CN484033 BC015354 AW612579 BQ651280 BC000940 
    BI492128 CN483805 BM915475 CD245144 AI264835 BX374887 AY388958 AL711409 
    CR620788 BM681123 BX281947 CA419472 BM927096 BC018968 BM807910 CD514746 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NKAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCCGGTGT
    NKAP Expression
    About this image

    NKAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NKAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522771
        Custom PCR Arrays for NKAP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NKAP
    OriGene qSTAR qPCR primer pairs in human, mouse for NKAP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NKAP
    QuantiTect SYBR Green Assays in human, mouse, rat NKAP
    QuantiFast Probe-based Assays in human, mouse, rat NKAP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NKAP gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nkap1 , 5 NFKB activating protein1, 5 84.1(n)1
    86.92(a)1
      X (21.54 cM)5
    670501  NM_025937.41  NP_080213.31 
     371267955 
    chicken
    (Gallus gallus)
    Aves NKAP6
    Gallus gallus NFKB activating protein (NKAP), mRNA...
    71(a)
    1 → many
    4(16444252-16448451)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    1 → many
    GL343950.1(64924-73433)
    African clawed frog
    (Xenopus laevis)
    Amphibia nuc06-A-prov2 similar to hypothetical protein FLJ22626 75.48(n)    AF001166.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj36d092 Transcribed sequence with moderate similarity to protein more 80.22(n)    BI883712.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60666
    --
    33(a)
    1 → many
    3R(22940953-22942398)
    worm
    (Caenorhabditis elegans)
    Secernentea let-5046
    Protein LET-504 (let-504) mRNA, complete cds
    25(a)
    1 → many
    I(4129564-4132292) WBGene00002696


    ENSEMBL Gene Tree for NKAP (if available)
    TreeFam Gene Tree for NKAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NKAP gene
    NKAPL2  
    1 SIMAP similar gene for NKAP using alignment to 3 protein entries:     NKAP_HUMAN (see all proteins):
    NKAPL

    Find genes that share paralogs with NKAP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NKAP (see all 306)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857325741,2
    --119052183(+) CTGGAA/GTGCAG 1 -- ds50010--------
    rs1942941,2
    C,F--119052256(+) CCTCTT/CGAGTA 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1873270161,2
    --119052303(+) ATTTTC/GTATTT 1 -- ds50010--------
    rs1919052431,2
    --119052440(+) ATTTGG/TATTTT 1 -- ds50010--------
    rs1843353211,2
    --119052505(+) TTATAA/TCAATA 1 -- ut310--------
    rs115508891,2
    C--119052599(+) TTCTAT/GGTATG 1 -- ut311Minor allele frequency- G:0.00NA 2
    rs1884461021,2
    --119053075(+) GATCTC/TGGCTC 1 -- int10--------
    rs59572721,2
    C,F,A,H--119053212(+) gatctT/Cgaact 1 -- int12Minor allele frequency- C:0.00NA WA 4
    rs1813419001,2
    --119053218(+) GAACTC/GCTGAC 1 -- int10--------
    rs1139760461,2
    C--119053240(+) CGCCTC/GTCTCA 1 -- int11Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for NKAP (119059013 - 119077735 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NKAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7059CNV Insertion18451855
    nsv425243CNV Loss16902084
    nsv9969CNV Gain18304495
    esv26416CNV Gain19812545
    dgv2469e1CNV Complex17122850
    dgv2468e1CNV Complex17122850

    Locus Specific Mutation Databases (LSDB): NKAP

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NKAP
    DNA2.0 Custom Variant and Variant Library Synthesis for NKAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300766    OMIM disorders: --


    Find genes that share disorders with NKAP           About GenesLikeMe

    Genetic Association Database (GAD): NKAP
    Human Genome Epidemiology (HuGE) Navigator: NKAP (1 document)

    Export disorders for NKAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NKAP gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with NKAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a nuclear protein that promotes NF-kappaB activation. (PubMed id 14550261)1, 2, 3 Chen D.... Shu H.-B. (Biochem. Biophys. Res. Commun. 2003)
    2. Association of genetic profiles to Crohn's disease by linear combinations of single nucleotide polymorphisms. (PubMed id 18804983)1, 4 D'Addabbo A....Ancona N. (Artif Intell Med 2009)
    3. NKAP is a transcriptional repressor of notch signaling and is required for T cell development. (PubMed id 19409814)1, 2 Pajerowski A.G.... Shapiro V.S. (Immunity 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    10. NKAP is required for T cell maturation and acquisition of functional competency. (PubMed id 21624937)1 Hsu F.C....Shapiro V.S. (J. Exp. Med. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79576 HGNC: 29873 AceView: NKAP Ensembl:ENSG00000101882 euGenes: HUgn79576
    ECgene: NKAP H-InvDB: NKAP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NKAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NKAP gene:
    Search GeneIP for patents involving NKAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NKAP  
     OriGene qPCR primer pairs and template standards for NKAP   OriGene Protein Over-expression Lysate for NKAP  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NKAP  
     OriGene qSTAR qPCR primer pairs in human, mouse for NKAP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NKAP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NKAP   OriGene Custom Protein Services for NKAP  

     
     
     Block miRNA regulation of human, mouse, rat NKAP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NKAP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKAP Predesigned siRNA for gene silencing in human, mouse, rat NKAP
     QuantiFast Probe-based Assays in human, mouse, rat NKAP QuantiTect SYBR Green Assays in human, mouse, rat NKAP
     Custom PCR Arrays for NKAP Search Chromatin IP Primers for NKAP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NKAP  Search GeneGlobe Interaction Network for NKAP
     Regulatory tfbs in NKAP promoter
     GenScript Custom Purified and Recombinant Proteins Services for NKAP GenScript cDNA clones with any tag delivered in your preferred vector for NKAP
     GenScript Custom Assay Services for NKAP GenScript Custom overexpressing Cell Line Services for NKAP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NKAP
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NKAP antibodies
     NKAP lysates
     Antibodies for NKAP
     See all of Abcam's Antibodies, Kits and Proteins for NKAP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NKAP
     Antibodies for NKAP
     ELISAs for NKAP
     CLIAs for NKAP



     Browse ESI BIO Cell Lines and PureStem Progenitors for NKAP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAP
     SwitchGear 3'UTR luciferase reporter plasmids for NKAP
     SwitchGear Promoter luciferase reporter plasmids for NKAP
     ThermoFisher Antibodies for NKAP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKAP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NKAP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NKAP
     LSBio Antibodies in human, mouse, rat for NKAP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NKAP
      Search eBioscience for proteins for NKAP
      Search eBioscience for elisas for NKAP
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NKAP gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4