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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NKAIN4 Gene

protein-coding GIFtS: 41
GCID: GC20M061869

Na+/K+ transporting ATPase interacting 4

(Previous name: chromosome 20 open reading frame 58 )
(Previous symbol: C20orf58)

Search for NKAIN4
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Na+/K+ Transporting ATPase Interacting 4¹ ²		Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein 4² ³
C20orf58¹ ² ³		Chromosome 20 Open Reading Frame 58¹
FAM77A¹ ² ³		Sodium/Potassium-Transporting ATPase Subunit Beta-1-Interacting Protein 4²
BA261N11.2¹		Protein FAM77A³

External Ids:	HGNC: 16191¹	Entrez Gene: 128414²	Ensembl: ENSG00000101198⁷	OMIM: 612873⁵	UniProtKB: Q8IVV8³

Export aliases for NKAIN4 gene to outside databases

Previous GC identifers: GC20M061337 GC20M058597

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NKAIN4:

NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and

interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 (PubMed

17606467)).(supplied by OMIM, Jun 2009)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011333.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NKAIN4 gene promoter:
AP-1 ATF-2 c-Jun HNF-4alpha2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKAIN4 promoter sequence

Search SABiosciences Chromatin IP Primers for NKAIN4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKAIN4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33

NKAIN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKAIN4 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M061869: view genomic region (about GC identifiers)

Start:	61,872,136 bp from pter	End:	61,904,046 bp from pter
Size:	31,911 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NKAI4_HUMAN, Q8IVV8 (See protein sequence)

Recommended Name: Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4

Size: 208 amino acids; 23240 Da

Subunit: Interacts with ATP1B1 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q4VXQ6 Q9BQU8 Q9BQU9

Explore the universe of human proteins at neXtProt for NKAIN4: NX_Q8IVV8

NKAIN4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_690603.3

ENSEMBL proteins:

ENSP00000359336 ENSP00000359340 ENSP00000359330 ENSP00000359341

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	Uscn Proteins for NKAIN4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

NKAIN4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NKAIN4 for domains About GeneDecksing

1 InterPro domain/family:

IPR008516 Na/K-Atpase_Interacting

Graphical View of Domain Structure for InterPro Entry Q8IVV8

ProtoNet protein and cluster: Q8IVV8

UniProtKB/Swiss-Prot: NKAI4_HUMAN, Q8IVV8

Similarity: Belongs to the NKAIN family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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2 GenomeRNAi human phenotypes for NKAIN4:

Decreased viability with pacli

Increased gamma-H2AX phosphory

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nkain4):

no phenotypic analysis

NKAIN4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NKAIN4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for NKAIN4 gene:

NM_152864.3

Unigene Cluster for NKAIN4:

Na+/K+ transporting ATPase interacting 4

Hs.46627 [show with all ESTs]

Unigene Representative Sequence: AK308958

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370313 ENST00000370316(uc002yek.3) ENST00000466885 ENST00000470246

ENST00000370307 ENST00000370317 ENST00000486495(uc010gkd.1) ENST00000461738

ENST00000472670

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Additional cDNA sequence:

AK126246.1 AK225765.1 AK308958.1 BC041812.1

10 DOTS entries:

DT.313230 DT.120811261 DT.120811254 DT.99952804 DT.120811258 DT.120811275 DT.120811259 DT.313228

DT.92420627 DT.95080701

24/106 AceView cDNA sequences (see all 106):

BE504796 AI968164 BE857508 AI569665 BE504963 BF739879 AI422871 F04093

AI522193 BE671805 BP350009 BP350285 AI266443 AI493014 BM692343 AI918153

AW591198 AI953726 AI433327 BM696562 BF592130 AA424030 BP349408 NM_152864

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NKAIN4 (see all 11) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b
SP1:							-		-		-						-						-		-		-						-		-		-
SP2:							-		-		-						-						-		-		-						-		-		-				-
SP3:																	-						-		-		-						-
SP4:																	-						-		-		-						-		-		-
SP5:																							-		-		-						-		-

ECgene alternative splicing isoforms for NKAIN4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NKAIN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

NKAIN4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NKAIN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NKAIN4

SOURCE GeneReport for Unigene cluster: Hs.46627

SABiosciences Custom PCR Arrays for NKAIN4

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NKAIN4 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NKAIN4¹	Na+/K+ transporting ATPase interacting 4	74.36(n) 72.6(a)		419240 XM_003642483.1 XP_003642531.1
lizard (Anolis carolinensis)	Reptilia	NKAIN4⁶	--	64(a)	1 ↔ 1	4(153340807-153375100)
African clawed frog (Xenopus laevis)	Amphibia	CD328764.1²	--	77.3(n)		CD328764.1
zebrafish (Danio rerio)	Actinopterygii	nkain4¹	Na+/K+ transporting ATPase interacting 4	71.08(n) 70.59(a)		100002876 NM_001113646.1 NP_001107118.1
fruit fly (Drosophila melanogaster)	Insecta	NKAIN⁶	Na,K-ATPase Interacting	12(a)	1 → many	2R(20769075-20776138)

ENSEMBL Gene Tree for NKAIN4 (if available)
TreeFam Gene Tree for NKAIN4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NKAIN4 gene

NKAIN1² NKAIN2² NKAIN3²

4 SIMAP similar genes for NKAIN4 using alignment to 4 protein entries: NKAI4_HUMAN (see all proteins):

NKAIN3 NKAIN2 NKAIN1 TCBA1

NKAIN4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80133670^1,2		--	61872401(+)	`GCCCTC/TACCGC`	1	--	ut3¹		1		WA	118
rs73316034^1,2	C,F,	--	61872450(+)	`GCTGCA/TTCCCA`	1	--	ut3¹		3		WA CSA	122
rs6089867^1,2		--	61872548(+)	`GAGCTG/TTGACC`	1	--	ut3¹ ese³		0	--	--	--	--
rs141566042^1,2		--	61872603(+)	`TTTTGC/TATGTT`	1	--	ut3¹		0	--	--	--	--
rs147053244^1,2		--	61872659(+)	`TTGACA/GCTGCA`	1	--	ut3¹		0	--	--	--	--
rs138237019^1,2		--	61872762(+)	`GGGCGC/TGTCCC`	1	--	ut3¹		0	--	--	--	--
rs201870337^1,2		--	61872883(+)	`GAGCAC/TCTGGG`	1	--	int¹		0	--	--	--	--
rs1047826^1,2	C,F,A,H,	--	61872905(-)	`GTGGCC/TGCCCC`	1	--	int¹		14		EA NS NA WA CSA	554
rs115146906^1,2		--	61872917(+)	`GGGGGC/ATGCCA`	1	--	int¹		1		WA	118
rs187633087^1,2		--	61872964(+)	`CCAAGC/TAGTGG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NKAIN4 (61872136 - 61904046 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for NKAIN4
11 CNVs: 5148 5147 31044 59579 50711 53414 53464 7315 59580 30133 30134

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NKAIN4 for disorders About MalaCards

NKAIN4 for disorders About GeneDecksing

OMIM gene information: 612873 OMIM disorders: --

Export disorders for NKAIN4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NKAIN4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NKAIN4)

Utopia: connect your pdf to the dynamic
world of online information

A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. (PubMed id 17606467)^{1, 3} Gorokhova S....Heintz N. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 128414	HGNC: 16191	AceView: C20orf58	Ensembl:ENSG00000101198	euGenes: HUgn128414
ECgene: NKAIN4	H-InvDB: NKAIN4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NKAIN4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NKAIN4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NKAIN4 gene:
Search GeneIP for patents involving NKAIN4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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NKAIN4 Gene

Na+/K+ transporting ATPase interacting 4

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NKAIN4 Gene

Na+/K+ transporting ATPase interacting 4

Aliasesfor NKAIN4 gene

Summariesfor NKAIN4 gene

Genomic Viewsfor NKAIN4 gene

Proteinsfor NKAIN4 gene

Protein Domains /Familiesfor NKAIN4 gene

Functionfor NKAIN4 gene

Pathways & Interactionsfor NKAIN4 gene

Drugs & Compoundsfor NKAIN4 gene

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Expression for NKAIN4 gene

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Genome Databases showing NKAIN4 gene

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Specialized Databases showing NKAIN4 gene

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Aliases
for NKAIN4 gene

Summaries
for NKAIN4 gene

Genomic Views
for NKAIN4 gene

Proteins
for NKAIN4 gene

Protein Domains /
Families
for NKAIN4 gene

Function
for NKAIN4 gene

Pathways & Interactions
for NKAIN4 gene

Drugs & Compounds
for NKAIN4 gene

Transcripts
for NKAIN4 gene

Expression
for NKAIN4 gene

Orthologs
for NKAIN4 gene

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for NKAIN4 gene

Genomic Variants
for NKAIN4 gene

Disorders / Diseases
for NKAIN4 gene

Publications
for NKAIN4 gene

Intellectual Property
for NKAIN4 gene

Products
for NKAIN4 gene