Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NKAIN4 Gene

Aliases for NKAIN4 Gene

  • Sodium/Potassium Transporting ATPase Interacting 4 2 3 5
  • Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein 4 3 4
  • Na+/K+ Transporting ATPase Interacting 4 2 3
  • C20orf58 3 4
  • FAM77A 3 4
  • Sodium/Potassium-Transporting ATPase Subunit Beta-1-Interacting Protein 4 3
  • Chromosome 20 Open Reading Frame 58 2
  • Protein FAM77A 4
  • BA261N11.2 3

External Ids for NKAIN4 Gene

Previous HGNC Symbols for NKAIN4 Gene

  • C20orf58

Previous GeneCards Identifiers for NKAIN4 Gene

  • GC20M061337
  • GC20M061869
  • GC20M058597

Summaries for NKAIN4 Gene

Entrez Gene Summary for NKAIN4 Gene

  • NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

GeneCards Summary for NKAIN4 Gene

NKAIN4 (Sodium/Potassium Transporting ATPase Interacting 4) is a Protein Coding gene. An important paralog of this gene is NKAIN2.

Additional gene information for NKAIN4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAIN4 Gene

Genomics for NKAIN4 Gene

Regulatory Elements for NKAIN4 Gene

Enhancers for NKAIN4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H063264 1.3 FANTOM5 Ensembl ENCODE 13.9 +5.5 5510 5.4 BCOR MXI1 SAP130 BACH1 ARID4B ZMYM3 DMAP1 TEAD3 ZFHX2 ZNF316 BIRC7 MIR647 COL20A1 DIDO1 UCKL1 LAMA5 NKAIN4 ENSG00000237371 ARFGAP1 RTEL1
GH20H063230 1.2 Ensembl ENCODE 12.4 +39.2 39222 6.6 ARID4B SIN3A DMAP1 ZBTB7B GLIS2 ZNF143 KLF7 FOS SP5 MIER2 BIRC7 PRPF6 NKAIN4 ARFGAP1 ENSG00000231977 PIR51008
GH20H063223 1.2 Ensembl ENCODE 11.8 +48.0 48025 1.8 NFIB SIN3A FEZF1 RAD21 GLIS2 SCRT2 ZNF143 RCOR1 SMARCA5 ZNF654 BIRC7 NKAIN4 PIR51008
GH20H063252 0.9 Ensembl ENCODE 14.6 +18.2 18156 4.3 CTCF ZBTB8A ATF2 POLR2A SCRT2 CTBP2 ZNF600 ZBTB26 ZBTB20 EZH2 BIRC7 NKAIN4 COL20A1 RNU6-994P ENSG00000231977 MIR124-3 ARFGAP1 FLJ16779 GC20M063249
GH20H063260 0.7 ENCODE 13.5 +11.2 11199 1.7 GATAD2A SAP130 NFXL1 ZIC2 ZGPAT POLR2A GLIS1 CEBPA MBD1 TCF7 BIRC7 DIDO1 MIR647 UCKL1 NKAIN4 ENSG00000237371 COL20A1 RNU6-994P LAMA5 ENSG00000226332
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NKAIN4 on UCSC Golden Path with GeneCards custom track

Promoters for NKAIN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139876 -206 1801 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF143 SP5 ZHX2

Genomic Locations for NKAIN4 Gene

Genomic Locations for NKAIN4 Gene
31,911 bases
Minus strand

Genomic View for NKAIN4 Gene

Genes around NKAIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAIN4 Gene

Proteins for NKAIN4 Gene

  • Protein details for NKAIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
    Protein Accession:
    Secondary Accessions:
    • Q4VXQ6
    • Q9BQU8
    • Q9BQU9

    Protein attributes for NKAIN4 Gene

    208 amino acids
    Molecular mass:
    23240 Da
    Quaternary structure:
    • Interacts with ATP1B1.

neXtProt entry for NKAIN4 Gene

Post-translational modifications for NKAIN4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NKAIN4 Gene

Domains & Families for NKAIN4 Gene

Gene Families for NKAIN4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NKAIN4 Gene


Suggested Antigen Peptide Sequences for NKAIN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NKAIN family.
  • Belongs to the NKAIN family.
genes like me logo Genes that share domains with NKAIN4: view

Function for NKAIN4 Gene

Phenotypes From GWAS Catalog for NKAIN4 Gene

genes like me logo Genes that share phenotypes with NKAIN4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NKAIN4 Gene

Localization for NKAIN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAIN4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKAIN4 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for NKAIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NKAIN4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NKAIN4 Gene

Pathways & Interactions for NKAIN4 Gene

SuperPathways for NKAIN4 Gene

No Data Available

Interacting Proteins for NKAIN4 Gene

Gene Ontology (GO) - Biological Process for NKAIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002028 regulation of sodium ion transport IBA --
genes like me logo Genes that share ontologies with NKAIN4: view

No data available for Pathways by source and SIGNOR curated interactions for NKAIN4 Gene

Drugs & Compounds for NKAIN4 Gene

No Compound Related Data Available

Transcripts for NKAIN4 Gene

Unigene Clusters for NKAIN4 Gene

Na+/K+ transporting ATPase interacting 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKAIN4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: -

Relevant External Links for NKAIN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKAIN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKAIN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKAIN4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.4), Kidney - Cortex (x5.7), Brain - Putamen (basal ganglia) (x5.5), Brain - Amygdala (x5.4), Brain - Caudate (basal ganglia) (x4.7), Brain - Substantia nigra (x4.2), and Brain - Hippocampus (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of NKAIN4 Gene:


SOURCE GeneReport for Unigene cluster for NKAIN4 Gene:


Evidence on tissue expression from TISSUES for NKAIN4 Gene

  • Nervous system(4.7)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with NKAIN4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKAIN4 Gene

Orthologs for NKAIN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKAIN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NKAIN4 33 34
  • 98.08 (n)
(Canis familiaris)
Mammalia NKAIN4 33 34
  • 84.38 (n)
(Mus musculus)
Mammalia Nkain4 33 16 34
  • 82.53 (n)
(Ornithorhynchus anatinus)
Mammalia NKAIN4 34
  • 73 (a)
(Monodelphis domestica)
Mammalia NKAIN4 34
  • 72 (a)
(Gallus gallus)
Aves NKAIN4 33 34
  • 74.36 (n)
(Anolis carolinensis)
Reptilia NKAIN4 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89467 33
  • 70.51 (n)
(Danio rerio)
Actinopterygii nkain4 33 34
  • 71.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta NKAIN 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3479 34
  • 29 (a)
Species where no ortholog for NKAIN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKAIN4 Gene

Gene Tree for NKAIN4 (if available)
Gene Tree for NKAIN4 (if available)

Paralogs for NKAIN4 Gene

Paralogs for NKAIN4 Gene

(4) SIMAP similar genes for NKAIN4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NKAIN4: view

Variants for NKAIN4 Gene

Sequence variations from dbSNP and Humsavar for NKAIN4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000103456 -- 63,245,842(+) TCCCC(A/G)ACCAT intron-variant, reference, missense
rs1000134541 -- 63,245,661(+) TCCAT(C/T)CCCAG intron-variant, reference, synonymous-codon
rs1000155526 -- 63,253,750(+) CCAAT(A/C)CCGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000180622 -- 63,256,541(+) GCGGG(G/T)TCGGT nc-transcript-variant, upstream-variant-2KB
rs1000267582 -- 63,255,373(+) CGGGA(A/G)ATCAG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NKAIN4 Gene

Variant ID Type Subtype PubMed ID
nsv9825 CNV gain 18304495
nsv953306 CNV deletion 24416366
nsv834032 CNV loss 17160897
nsv834031 CNV loss 17160897
nsv820146 CNV gain 19587683
nsv819591 CNV gain 19587683
nsv586563 CNV loss 21841781
nsv586562 CNV gain 21841781
nsv586559 CNV gain 21841781
nsv525279 CNV loss 19592680
nsv522880 CNV loss 19592680
nsv518905 CNV loss 19592680
nsv517648 CNV loss 19592680
nsv470560 CNV loss 18288195
nsv3446 CNV deletion 18451855
nsv1114236 CNV deletion 24896259
esv3893360 CNV loss 25118596
esv32831 CNV loss 17666407
esv2722898 CNV deletion 23290073
dgv7665n54 CNV loss 21841781
dgv7664n54 CNV loss 21841781
dgv520n27 CNV loss 19166990
dgv519n27 CNV loss 19166990

Variation tolerance for NKAIN4 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.29; 95.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKAIN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAIN4 Gene

Disorders for NKAIN4 Gene

Relevant External Links for NKAIN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NKAIN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAIN4 Gene

Publications for NKAIN4 Gene

  1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. (PMID: 17606467) Gorokhova S … Heintz N (Human molecular genetics 2007) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for NKAIN4 Gene

Sources for NKAIN4 Gene

Loading form....