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Aliases for NKAIN4 Gene

Aliases for NKAIN4 Gene

  • Na+/K+ Transporting ATPase Interacting 4 2 3 5
  • Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein 4 3 4
  • C20orf58 3 4
  • FAM77A 3 4
  • Chromosome 20 Open Reading Frame 58 2
  • Protein FAM77A 4
  • BA261N11.2 3

External Ids for NKAIN4 Gene

Previous HGNC Symbols for NKAIN4 Gene

  • C20orf58

Previous GeneCards Identifiers for NKAIN4 Gene

  • GC20M061337
  • GC20M061869
  • GC20M058597

Summaries for NKAIN4 Gene

Entrez Gene Summary for NKAIN4 Gene

  • NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

GeneCards Summary for NKAIN4 Gene

NKAIN4 (Na+/K+ Transporting ATPase Interacting 4) is a Protein Coding gene. An important paralog of this gene is NKAIN2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAIN4 Gene

Genomics for NKAIN4 Gene

Regulatory Elements for NKAIN4 Gene

Promoters for NKAIN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NKAIN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NKAIN4 Gene

Chromosome:
20
Start:
63,240,784 bp from pter
End:
63,272,694 bp from pter
Size:
31,911 bases
Orientation:
Minus strand

Genomic View for NKAIN4 Gene

Genes around NKAIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAIN4 Gene

Proteins for NKAIN4 Gene

  • Protein details for NKAIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVV8-NKAI4_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
    Protein Accession:
    Q8IVV8
    Secondary Accessions:
    • Q4VXQ6
    • Q9BQU8
    • Q9BQU9

    Protein attributes for NKAIN4 Gene

    Size:
    208 amino acids
    Molecular mass:
    23240 Da
    Quaternary structure:
    • Interacts with ATP1B1.

neXtProt entry for NKAIN4 Gene

Proteomics data for NKAIN4 Gene at MOPED

Post-translational modifications for NKAIN4 Gene

No Post-translational modifications

Other Protein References for NKAIN4 Gene

Antibody Products

No data available for DME Specific Peptides for NKAIN4 Gene

Domains & Families for NKAIN4 Gene

Gene Families for NKAIN4 Gene

Protein Domains for NKAIN4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKAIN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVV8

UniProtKB/Swiss-Prot:

NKAI4_HUMAN :
  • Belongs to the NKAIN family.
Family:
  • Belongs to the NKAIN family.
genes like me logo Genes that share domains with NKAIN4: view

Function for NKAIN4 Gene

genes like me logo Genes that share phenotypes with NKAIN4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NKAIN4

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NKAIN4 Gene

Localization for NKAIN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAIN4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKAIN4 Gene COMPARTMENTS Subcellular localization image for NKAIN4 gene
Compartment Confidence
plasma membrane 4
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for NKAIN4 Gene

Pathways & Interactions for NKAIN4 Gene

SuperPathways for NKAIN4 Gene

No Data Available

Interacting Proteins for NKAIN4 Gene

Gene Ontology (GO) - Biological Process for NKAIN4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NKAIN4 Gene

Drugs & Compounds for NKAIN4 Gene

No Compound Related Data Available

Transcripts for NKAIN4 Gene

Unigene Clusters for NKAIN4 Gene

Na+/K+ transporting ATPase interacting 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKAIN4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: -

Relevant External Links for NKAIN4 Gene

GeneLoc Exon Structure for
NKAIN4
ECgene alternative splicing isoforms for
NKAIN4

Expression for NKAIN4 Gene

mRNA expression in normal human tissues for NKAIN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKAIN4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.4), Kidney - Cortex (x5.7), Brain - Putamen (basal ganglia) (x5.5), Brain - Amygdala (x5.4), Brain - Caudate (basal ganglia) (x4.7), Brain - Substantia nigra (x4.2), and Brain - Hippocampus (x4.1).

SOURCE GeneReport for Unigene cluster for NKAIN4 Gene Hs.46627

genes like me logo Genes that share expression patterns with NKAIN4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NKAIN4 Gene

Orthologs for NKAIN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKAIN4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NKAIN4 35
  • 84.38 (n)
  • 79.71 (a)
NKAIN4 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkain4 35
  • 82.53 (n)
  • 83.17 (a)
Nkain4 16
Nkain4 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NKAIN4 35
  • 98.08 (n)
  • 96.15 (a)
NKAIN4 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKAIN4 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKAIN4 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKAIN4 35
  • 74.36 (n)
  • 72.6 (a)
NKAIN4 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKAIN4 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89467 35
  • 70.51 (n)
  • 69.71 (a)
zebrafish
(Danio rerio)
Actinopterygii nkain4 35
  • 71.08 (n)
  • 70.59 (a)
nkain4 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NKAIN 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3479 36
  • 29 (a)
OneToMany
Species with no ortholog for NKAIN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKAIN4 Gene

ENSEMBL:
Gene Tree for NKAIN4 (if available)
TreeFam:
Gene Tree for NKAIN4 (if available)

Paralogs for NKAIN4 Gene

Paralogs for NKAIN4 Gene

(4) SIMAP similar genes for NKAIN4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NKAIN4: view

Variants for NKAIN4 Gene

Sequence variations from dbSNP and Humsavar for NKAIN4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1129659 - 63,248,817(-) TCTTA(A/C)AGGTG reference, missense
rs2236194 - 63,247,657(+) CCAGG(G/T)CCTGG reference, missense
rs872808 - 63,247,598(+) CAGGC(A/C/T)ACTGT reference, missense
rs11556207 - 63,244,037(+) TCTTC(A/C)TCCGT reference, missense
rs1047819 -- 63,241,728(-) CTGAG(A/T)TGTCA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NKAIN4 Gene

Variant ID Type Subtype PubMed ID
nsv913073 CNV Loss 21882294
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
nsv913161 CNV Loss 21882294
nsv913165 CNV Loss 21882294
nsv913166 CNV Loss 21882294
nsv834031 CNV Loss 17160897
dgv519n27 CNV Loss 19166990
dgv4626n71 CNV Loss 21882294
dgv4627n71 CNV Loss 21882294
dgv4628n71 CNV Loss 21882294
dgv4629n71 CNV Loss 21882294
nsv834032 CNV Loss 17160897
dgv520n27 CNV Loss 19166990
nsv517648 CNV Loss 19592680
nsv819591 CNV Gain 19587683
nsv518905 CNV Loss 19592680
nsv470560 CNV Loss 18288195
nsv525279 CNV Loss 19592680
nsv913177 CNV Loss 21882294
dgv4630n71 CNV Loss 21882294
nsv913180 CNV Loss 21882294
nsv820146 CNV Gain 19587683
nsv3446 CNV Loss 18451855
nsv522880 CNV Loss 19592680
nsv913181 CNV Loss 21882294
dgv4631n71 CNV Loss 21882294
esv2722898 CNV Deletion 23290073
esv32831 CNV Loss 17666407

Variation tolerance for NKAIN4 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.29; 95.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKAIN4 Gene

HapMap Linkage Disequilibrium report
NKAIN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAIN4 Gene

Disorders for NKAIN4 Gene

Relevant External Links for NKAIN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKAIN4

No disorders were found for NKAIN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAIN4 Gene

Publications for NKAIN4 Gene

  1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. (PMID: 17606467) Gorokhova S. … Heintz N. (Hum. Mol. Genet. 2007) 2 3 67
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3

Products for NKAIN4 Gene

Sources for NKAIN4 Gene

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