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NKAIN2 Gene

protein-coding   GIFtS: 48
GCID: GC06P124125

Na+/K+ Transporting ATPase Interacting 2

(Previous name: T-cell lymphoma breakpoint associated target 1)
(Previous symbol: TCBA1)
  See NKAIN2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
Na+/K+ Transporting ATPase Interacting 21 2     TCBA2 5
TCBA11 2 3     T-Cell Lymphoma Breakpoint Associated Target 11
FAM77B2 3     NKAIP22
Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein 22 3     Sodium/Potassium-Transporting ATPase Subunit Beta-1-Interacting Protein 22
T-Cell Lymphoma Breakpoint-Associated Target Protein 12 3     Protein FAM77B3

External Ids:    HGNC: 164431   Entrez Gene: 1542152   Ensembl: ENSG000001885807   OMIM: 6097585   UniProtKB: Q5VXU13   

Export aliases for NKAIN2 gene to outside databases

Previous GC identifers: GC06P124167 GC06P121704


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


Entrez Gene summary for NKAIN2 Gene:
The protein encoded by this gene is a transmembrane protein that interacts with the beta subunit of Na,K-ATPase
(ATP1B1). A chromosomal translocation involving this gene is a cause of lymphoma. At least two transcript
variants encoding different isoforms have been found for this gene.(provided by RefSeq, May 2010)

GeneCards Summary for NKAIN2 Gene:
NKAIN2 (Na+/K+ transporting ATPase interacting 2) is a protein-coding gene. Diseases associated with NKAIN2 include genital herpes. An important paralog of this gene is NKAIN1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NKAIN2 gene promoter:
         Nkx3-1   HFH-3   TBP   Nkx3-1 v4   AP-2gamma   FOXL1   FOXI1   S8   HFH-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NKAIN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NKAIN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q21

NKAIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKAIN2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P124125:  view genomic region     (about GC identifiers)

Start:
124,125,069 bp from pter      End:
125,146,803 bp from pter
Size:
1,021,735 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section


UniProtKB/Swiss-Prot: NKAI2_HUMAN, Q5VXU1 (See protein sequence)
Recommended Name: Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2  
Size: 208 amino acids; 23831 Da
Subunit: Interacts with ATP1B1 (By similarity)
Secondary accessions: Q8IYR4 Q8TF67
Alternative splicing: 3 isoforms:  Q5VXU1-1   Q5VXU1-2   Q5VXU1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NKAIN2: NX_Q5VXU1

REFSEQ proteins (2 alternative transcripts): 
NP_001035304.1  NP_699186.2  

ENSEMBL proteins: 
 ENSP00000357401   ENSP00000357402   ENSP00000440287   ENSP00000437798  

NKAIN2 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for NKAIN2

 
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antibodies-online proteins for NKAIN2 

 
antibodies-online peptides for NKAIN2

NKAIN2 Antibody Products:

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antibodies-online antibodies for NKAIN2 (10 products) 

NKAIN2 Assay Products:

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antibodies-online kits for NKAIN2 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:
NKAIN: Na+/K+ transporting ATPase interacting

1 InterPro protein domain:
 IPR008516 Na/K-Atpase_Interacting

Graphical View of Domain Structure for InterPro Entry Q5VXU1

ProtoNet protein and cluster: Q5VXU1

UniProtKB/Swiss-Prot: NKAI2_HUMAN, Q5VXU1
Similarity: Belongs to the NKAIN family


Find genes that share domains with NKAIN2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for NKAIN2

miRNA
Products:
    
miRTarBase miRNAs that target NKAIN2:
hsa-mir-335-5p (MIRT017569)

Block miRNA regulation of human, mouse, rat NKAIN2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NKAIN2 (see all 37):
hsa-miR-4328 hsa-miR-30d hsa-miR-192 hsa-miR-1304 hsa-miR-374c hsa-miR-30a hsa-miR-3150b-3p hsa-miR-3613-3p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Gene Editing
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKAIN2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKAIN2

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAIN2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section


Subcellular locations from UniProtKB/Swiss-Prot
NKAI2_HUMAN, Q5VXU1: Cell membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with NKAIN2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section






    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NKAIN2
Interactions:

    Search GeneGlobe Interaction Network for NKAIN2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for NKAIN2 (ENSP000003574024) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ERCC1ENSP000000138074STRING: ENSP00000013807
RAD23AENSP000003213654STRING: ENSP00000321365
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NKAIN2 (NKAI2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section


REFSEQ mRNAs for NKAIN2 gene (4 alternative transcripts): 
NM_001040214.1  NM_153355.3  XM_005266833.1  XM_005266834.1  

Unigene Cluster for NKAIN2:

Na+/K+ transporting ATPase interacting 2
Hs.656604  [show with all ESTs]
Unigene Representative Sequence: NM_001040214
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000476571(uc010kep.1) ENST00000368416(uc003pzn.1) ENST00000368417(uc003pzo.3 uc010keq.3 uc003pzp.3 uc010ker.3)
ENST00000546092 ENST00000545433
miRNA
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Block miRNA regulation of human, mouse, rat NKAIN2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NKAIN2 (see all 37):
hsa-miR-4328 hsa-miR-30d hsa-miR-192 hsa-miR-1304 hsa-miR-374c hsa-miR-30a hsa-miR-3150b-3p hsa-miR-3613-3p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NKAIN2
Predesigned siRNA for gene silencing in human, mouse, rat NKAIN2
Clone
Products:
     
OriGene clones in human, mouse for NKAIN2 (see all 11)
OriGene ORF clones in mouse, rat for NKAIN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): NKAIN2 (NM_001040214)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NKAIN2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NKAIN2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for NKAIN2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NKAIN2
  QuantiTect SYBR Green Assays in human, mouse, rat NKAIN2
  QuantiFast Probe-based Assays in human, mouse, rat NKAIN2

Additional mRNA sequence: 

AK055326.1 AK308927.1 AK309385.1 AK309407.1 AK309802.1 AK310763.1 AK315886.1 BC035062.2 

8 DOTS entries:

DT.453164  DT.97798916  DT.75164334  DT.121377348  DT.121377417  DT.121377482  DT.65284714  DT.92420478 

15 AceView cDNA sequences:

BG184871 AI692199 AF150231 AI698525 BG198302 BG211287 R13164 BU101715 
AV743166 BG189072 BG201519 AW966299 BG184346 AB070452 BG202438 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NKAIN2    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1:                                            -                     
SP2:                    -                       -                     
SP3:                    -                                             


ECgene alternative splicing isoforms for NKAIN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NKAIN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TATATGGGTA
NKAIN2 Expression
About this image


NKAIN2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Brain (Nervous System)    fully expand to see all 16 entries
         Thalamus
         Oligodendrocyte-like cells
         Olfactory Bulb   
 
 Blood (Hematopoietic System)
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Spinal Cord (Nervous System)
         Oligodendrocyte-like cells
 
 Oligodendrocytes (Nervous System)
         Oligodendrocyte-like cells
 
 Ovary (Reproductive System)
NKAIN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.656604

UniProtKB/Swiss-Prot: NKAI2_HUMAN, Q5VXU1
Tissue specificity: Expressed in fetal brain. Weakly expressed in adult brain and thymus. Not expressed in any
other normal tissue examined

    Custom PCR Arrays for NKAIN2
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QuantiFast Probe-based Assays in human, mouse, rat NKAIN2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAIN2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section


This gene was present in the common ancestor of animals.

Orthologs for NKAIN2 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nkain21 , 5 Na+/K+ transporting ATPase interacting 21, 5 94.55(n)1
97.6(a)1
  10 (17.56 cM)5
4324501  NM_001013411.21  NP_001013429.21 
 316893195 
chicken
(Gallus gallus)
Aves NKAIN21 Na+/K+ transporting ATPase interacting 2 86.54(n)
94.23(a)
  421720  NM_001277834.1  NP_001264763.1 
lizard
(Anolis carolinensis)
Reptilia NKAIN26
Na+/K+ transporting ATPase interacting 2
81(a)
1 ↔ 1
1(181095279-181096670)
tropical clawed frog
(Xenopus tropicalis)
Amphibia nkain21 Na+/K+ transporting ATPase interacting 2 80.93(n)
85.58(a)
  100487100  XM_002936008.2  XP_002936054.2 
zebrafish
(Danio rerio)
Actinopterygii BM860184.12   -- 76.45(n)    BM860184.1 
fruit fly
(Drosophila melanogaster)
Insecta NKAIN6
Na,K-ATPase Interacting
13(a)
1 → many
2R(20769075-20776138)


ENSEMBL Gene Tree for NKAIN2 (if available)
TreeFam Gene Tree for NKAIN2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for NKAIN2 gene
NKAIN12  NKAIN42  NKAIN32  
4 SIMAP similar genes for NKAIN2 using alignment to 3 protein entries:     NKAI2_HUMAN (see all proteins):
TCBA1    NKAIN3    NKAIN1    NKAIN4

Find genes that share paralogs with NKAIN2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section


Selected SNPs for NKAIN2 (see all 20457)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs14597681,2
C,F--121702170(+) GAGCCG/CGGACG 2 -- us2k11Minor allele frequency- C:0.50NA 2
rs1458208791,2
C--121702188(+) TCGGCC/TCGCGC 2 -- us2k10--------
rs2019418371,2
C--121716695(+) TGGAA-/ACACAC
        
ACACA
2 -- int10--------
rs3746955461,2
C--121716695(+) TGGAA-/ACACACA 2 -- int10--------
rs1418972201,2
C--121745191(+) GCGCG-/CACACAC 2 -- int10--------
rs1387557611,2
C--121749583(+) TGGTT-/CTATTTTT 2 -- int10--------
rs1388715651,2
C--121772276(+) GTTTG-/TTTA  
        
TTTAT
2 -- int10--------
rs1481115311,2
C--121773230(+) ATTCC-/TAC   
   ATACA
TACAT
2 -- int10--------
rs722312111,2
C--121773231(+) ATTCC-/TACA  
        
TACAT
2 -- int10--------
rs1113870781,2
C--121776568(+) ATCTC-/AAAAAA 2 -- int11Minor allele frequency- A:0.50CSA 2

HapMap Linkage Disequilibrium report for NKAIN2 (124125069 - 124375069 bp, first 250kb of NKAIN2)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for NKAIN2 (see all 81):    About this table    
Variant IDTypeSubtypePubMed ID
esv3756CNV Deletion18987735
esv2663068CNV Deletion23128226
esv4901CNV Deletion18987735
esv2732667CNV Deletion23290073
esv2732662CNV Deletion23290073
esv1003542CNV Deletion20482838
esv2678659CNV Deletion23128226
esv2532592CNV Deletion19546169
esv2671870CNV Deletion23128226
esv2732664CNV Deletion23290073

Human Gene Mutation Database (HGMD): NKAIN2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NKAIN2
DNA2.0 Custom Variant and Variant Library Synthesis for NKAIN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 609758    OMIM disorders: --

UniProtKB/Swiss-Prot: NKAI2_HUMAN, Q5VXU1
  • Note=A chromosomal aberration involving NKAIN2 is a cause of lymphoma. Deletion del(6)(q13q21) within
    NKAIN2 and involving SUSP1 generates the SUSP1-NKAIN2 product

  • 1 disease for NKAIN2:    
    About MalaCards
    genital herpes

    1 inferred disease relationship from the University of Copenhagen DISEASES database for NKAIN2:
    Genital herpes

    Find genes that share disorders with NKAIN2           About GenesLikeMe

    Genetic Association Database (GAD): NKAIN2
    Human Genome Epidemiology (HuGE) Navigator: NKAIN2 (5 documents)

    Export disorders for NKAIN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for NKAIN2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with NKAIN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cytogenetic analysis of the breakpoint region at 6q21-22 in T-cell lymphoma/leukemia cell lines. (PubMed id 11979551)1, 2, 9 Tagawa H.... Seto M. (Genes Chromosomes Cancer 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A genome-wide association study of neuroticism in a population-based sample. (PubMed id 20634892)1, 4 Calboli F.C....Balding D.J. (PLoS ONE 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. (PubMed id 17606467)1, 3 Gorokhova S....Heintz N. (Hum. Mol. Genet. 2007)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Disruption of TCBA1 associated with a de novo t(1;6)(q32.2;q22.3) presenting in a child with developmental delay and recurrent infections. (PubMed id 15908570)1, 9 Yue Y....Haaf T. (J. Med. Genet. 2006)
    8. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (amp 2014)
    9. Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. (PubMed id 23534349)1 Jeff J.M....Crawford D.C. (Ann. Hum. Genet. 2013)
    10. A comprehensive family-based replication study of schizophrenia genes. (PubMed id 23894747)1 Aberg K.A....van den Oord E.J. (JAMA Psychiatry 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 154215 HGNC: 16443 AceView: TCBA1 Ensembl:ENSG00000188580 euGenes: HUgn154215
    ECgene: NKAIN2 H-InvDB: NKAIN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKAIN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NKAIN2 gene:
    Search GeneIP for patents involving NKAIN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section


     
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