Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NKAIN2 Gene

Aliases for NKAIN2 Gene

  • Na+/K+ Transporting ATPase Interacting 2 2 3 5
  • Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein 2 3 4
  • T-Cell Lymphoma Breakpoint-Associated Target Protein 1 3 4
  • FAM77B 3 4
  • TCBA1 3 4
  • T-Cell Lymphoma Breakpoint Associated Target 1 2
  • Protein FAM77B 4
  • NKAIP2 3
  • TCBA 3

External Ids for NKAIN2 Gene

Previous HGNC Symbols for NKAIN2 Gene

  • TCBA1

Previous GeneCards Identifiers for NKAIN2 Gene

  • GC06P124167
  • GC06P124125
  • GC06P121704

Summaries for NKAIN2 Gene

Entrez Gene Summary for NKAIN2 Gene

  • This gene encodes a transmembrane protein that interacts with the beta subunit of a sodium/potassium-transporting ATPase. A chromosomal translocation involving this gene is a cause of lymphoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for NKAIN2 Gene

NKAIN2 (Na+/K+ Transporting ATPase Interacting 2) is a Protein Coding gene. Diseases associated with NKAIN2 include lymphoma. An important paralog of this gene is NKAIN4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAIN2 Gene

Genomics for NKAIN2 Gene

Regulatory Elements for NKAIN2 Gene

Genomic Location for NKAIN2 Gene

123,803,837 bp from pter
124,825,657 bp from pter
1,021,821 bases
Plus strand

Genomic View for NKAIN2 Gene

Genes around NKAIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAIN2 Gene

Proteins for NKAIN2 Gene

  • Protein details for NKAIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8IYR4
    • Q8TF67

    Protein attributes for NKAIN2 Gene

    208 amino acids
    Molecular mass:
    23831 Da
    Quaternary structure:
    • Interacts with ATP1B1.

    Alternative splice isoforms for NKAIN2 Gene


neXtProt entry for NKAIN2 Gene

Proteomics data for NKAIN2 Gene at MOPED

Post-translational modifications for NKAIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKAIN2 Gene

No data available for DME Specific Peptides for NKAIN2 Gene

Domains & Families for NKAIN2 Gene

Gene Families for NKAIN2 Gene

Protein Domains for NKAIN2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NKAIN family.
  • Belongs to the NKAIN family.
genes like me logo Genes that share domains with NKAIN2: view

Function for NKAIN2 Gene

Phenotypes for NKAIN2 Gene

genes like me logo Genes that share phenotypes with NKAIN2: view

Animal Model Products

miRNA for NKAIN2 Gene

miRTarBase miRNAs that target NKAIN2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKAIN2 Gene

Localization for NKAIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAIN2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NKAIN2 Gene COMPARTMENTS Subcellular localization image for NKAIN2 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for NKAIN2 Gene

Pathways & Interactions for NKAIN2 Gene

SuperPathways for NKAIN2 Gene

No Data Available

Interacting Proteins for NKAIN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000357402 for NKAIN2 Gene via STRING

Gene Ontology (GO) - Biological Process for NKAIN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NKAIN2 Gene

Drugs & Compounds for NKAIN2 Gene

No Compound Related Data Available

Transcripts for NKAIN2 Gene

Unigene Clusters for NKAIN2 Gene

Na+/K+ transporting ATPase interacting 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKAIN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3: -

Relevant External Links for NKAIN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKAIN2 Gene

mRNA expression in normal human tissues for NKAIN2 Gene

mRNA differential expression in normal tissues according to GTEx for NKAIN2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x13.1), Brain - Substantia nigra (x5.8), Brain - Hippocampus (x5.3), Brain - Amygdala (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for NKAIN2 Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NKAIN2 Gene

SOURCE GeneReport for Unigene cluster for NKAIN2 Gene Hs.656604

mRNA Expression by UniProt/SwissProt for NKAIN2 Gene

Tissue specificity: Expressed in fetal brain. Weakly expressed in adult brain and thymus. Not expressed in any other normal tissue examined.
genes like me logo Genes that share expression patterns with NKAIN2: view

Protein tissue co-expression partners for NKAIN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NKAIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKAIN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NKAIN2 35
  • 97.75 (n)
  • 99.48 (a)
  • 93 (a)
(Mus musculus)
Mammalia Nkain2 35
  • 94.55 (n)
  • 97.6 (a)
Nkain2 16
Nkain2 36
  • 88 (a)
(Pan troglodytes)
Mammalia NKAIN2 35
  • 99.84 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC102551716 35
  • 94.53 (n)
  • 97.88 (a)
(Bos Taurus)
Mammalia -- 36
  • 93 (a)
-- 36
  • 100 (a)
(Monodelphis domestica)
Mammalia NKAIN2 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia NKAIN2 36
  • 56 (a)
(Gallus gallus)
Aves NKAIN2 35
  • 86.54 (n)
  • 94.23 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia NKAIN2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nkain2 35
  • 80.93 (n)
  • 85.58 (a)
(Danio rerio)
Actinopterygii LOC101883714 35
  • 73.96 (n)
  • 82.5 (a)
nkain2 36
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta NKAIN 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3479 36
  • 35 (a)
Species with no ortholog for NKAIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKAIN2 Gene

Gene Tree for NKAIN2 (if available)
Gene Tree for NKAIN2 (if available)

Paralogs for NKAIN2 Gene

Paralogs for NKAIN2 Gene

(4) SIMAP similar genes for NKAIN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NKAIN2: view

Variants for NKAIN2 Gene

Sequence variations from dbSNP and Humsavar for NKAIN2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs163283 -- 124,112,858(-) cacta(A/C)agggg intron-variant
rs163284 -- 124,110,366(-) AAACC(A/G)TTTAA intron-variant
rs163285 -- 124,109,834(-) caaaa(A/T)gaatt intron-variant
rs163286 -- 124,140,301(-) ACAGA(A/G)CTGTC intron-variant
rs163287 -- 124,133,597(-) ttttt(C/T)ctggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKAIN2 Gene

Variant ID Type Subtype PubMed ID
nsv524559 CNV Gain 19592680
esv1159785 CNV Insertion 17803354
esv2732662 CNV Deletion 23290073
nsv5462 CNV Insertion 18451855
nsv823835 CNV Loss 20364138
esv2732663 CNV Deletion 23290073
nsv483130 CNV Loss 15286789
esv34079 CNV Loss 18971310
esv2732664 CNV Deletion 23290073
nsv886610 CNV Loss 21882294
esv2663068 CNV Deletion 23128226
esv2732665 CNV Deletion 23290073
esv2732666 CNV Deletion 23290073
esv2156126 CNV Deletion 18987734
esv3756 CNV Deletion 18987735
esv2732667 CNV Deletion 23290073
esv2732668 CNV Deletion 23290073
esv1003542 CNV Deletion 20482838
nsv349664 CNV Loss 16902084
esv2565664 CNV Deletion 19546169
nsv886611 CNV Loss 21882294
nsv818453 CNV Gain 17921354
esv2752089 CNV Loss 17911159
nsv525167 CNV Loss 19592680
nsv464042 CNV Gain 19166990
nsv517303 CNV Gain 19592680
esv271914 CNV Insertion 20981092
nsv830794 CNV Gain 17160897
dgv783n27 CNV Gain 19166990
nsv886612 CNV Gain 21882294
esv29157 CNV Gain 19812545
esv2422137 CNV Duplication 20811451
nsv442007 CNV CNV 18776908
nsv514386 CNV Gain 21397061
nsv818454 CNV Gain 17921354
nsv470857 CNV Gain 18288195
nsv464054 CNV Gain 19166990
dgv6987n71 CNV Loss 21882294
esv2616735 CNV Deletion 19546169
esv2132883 CNV Deletion 18987734
esv2732669 CNV Deletion 23290073
esv4901 CNV Deletion 18987735
esv5558 CNV Loss 19470904
esv270121 CNV Insertion 20981092
esv2671870 CNV Deletion 23128226
nsv886615 CNV Loss 21882294
nsv464055 CNV Loss 19166990
nsv5463 CNV Loss 18451855
nsv470858 CNV Gain 18288195
esv268470 CNV Insertion 20981092
esv273933 CNV Insertion 20981092
nsv886616 CNV Gain 21882294
esv2532592 CNV Deletion 19546169
dgv6988n71 CNV Gain 21882294
nsv464057 CNV Gain 19166990
nsv886618 CNV Gain 21882294
nsv470859 CNV Gain 18288195
nsv886621 CNV Loss 21882294
nsv348535 CNV Loss 16902084
esv267914 CNV Insertion 20981092
nsv886622 CNV Gain 21882294
esv998361 CNV Gain 20482838
esv2571117 CNV Deletion 19546169
esv2732670 CNV Deletion 23290073
esv2403297 CNV Deletion 18987734
esv2843 CNV Deletion 18987735
esv2732671 CNV Deletion 23290073
esv2678659 CNV Deletion 23128226
nsv886623 CNV Gain 21882294
esv269696 CNV Insertion 20981092
esv2732673 CNV Deletion 23290073
nsv348725 CNV Loss 16902084
esv259742 OTHER Complex 20981092
nsv5464 CNV Loss 18451855
nsv512893 CNV Insertion 21212237
esv1062584 CNV Insertion 17803354
esv1174920 CNV Insertion 17803354
esv1164700 CNV Insertion 17803354
esv2732674 CNV Deletion 23290073
esv2299970 CNV Deletion 18987734
esv2675725 CNV Deletion 23128226

Variation tolerance for NKAIN2 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKAIN2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAIN2 Gene

Disorders for NKAIN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NKAIN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving NKAIN2 is a cause of lymphoma. Deletion del(6)(q13q21) within NKAIN2 and involving SUSP1 generates the SUSP1-NKAIN2 product (PubMed:11979551). {ECO:0000269 PubMed:11979551}.

Relevant External Links for NKAIN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NKAIN2: view

No data available for Genatlas for NKAIN2 Gene

Publications for NKAIN2 Gene

  1. Molecular cytogenetic analysis of the breakpoint region at 6q21-22 in T-cell lymphoma/leukemia cell lines. (PMID: 11979551) Tagawa H. … Seto M. (Genes Chromosomes Cancer 2002) 3 4 23 67
  2. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. (PMID: 17606467) Gorokhova S. … Heintz N. (Hum. Mol. Genet. 2007) 2 3
  3. Disruption of TCBA1 associated with a de novo t(1;6)(q32.2;q22.3) presenting in a child with developmental delay and recurrent infections. (PMID: 15908570) Yue Y. … Haaf T. (J. Med. Genet. 2006) 3 23
  4. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3
  5. Genetic influences on political ideologies: twin analyses of 19 measures of political ideologies from five democracies and genome-wide findings from three populations. (PMID: 24569950) Hatemi P.K. … Martin N.G. (Behav. Genet. 2014) 3

Products for NKAIN2 Gene

Sources for NKAIN2 Gene

Back to Top