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Aliases for NKAIN1 Gene

Aliases for NKAIN1 Gene

  • Sodium/Potassium Transporting ATPase Interacting 1 2 3 5
  • Sodium/Potassium-Transporting ATPase Subunit Beta-1-Interacting Protein 1 2 3
  • Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein 1 3 4
  • Family With Sequence Similarity 77, Member C 2 3
  • Na+/K+ Transporting ATPase Interacting 1 2 3
  • FAM77C 3 4
  • Protein FAM77C 4

External Ids for NKAIN1 Gene

Previous HGNC Symbols for NKAIN1 Gene

  • FAM77C

Previous GeneCards Identifiers for NKAIN1 Gene

  • GC01M031426
  • GC01M031652
  • GC01M029759

Summaries for NKAIN1 Gene

Entrez Gene Summary for NKAIN1 Gene

  • NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

GeneCards Summary for NKAIN1 Gene

NKAIN1 (Sodium/Potassium Transporting ATPase Interacting 1) is a Protein Coding gene. An important paralog of this gene is NKAIN2.

Additional gene information for NKAIN1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAIN1 Gene

Genomics for NKAIN1 Gene

Regulatory Elements for NKAIN1 Gene

Enhancers for NKAIN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H031169 1.8 FANTOM5 Ensembl ENCODE 14.6 +67.5 67508 5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ENSG00000229447 NKAIN1 KPNA6 KHDRBS1 SNRNP40 PUM1 LOC105378626 TMEM39B GC01M031217 RPL21P22
GH01H031206 0.7 dbSUPER 34.1 +31.8 31841 2 BCOR ELF3 HLF CEBPB ZMYM3 CEBPG RARA NFIL3 HDAC2 ADNP NKAIN1 ENSG00000229044 SERINC2 KHDRBS1 GC01M031217 RPL21P22
GH01H031181 1.3 Ensembl ENCODE 15.2 +57.7 57718 1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF766 CBX5 ZNF143 NKAIN1 GC01M031217 RPL21P22
GH01H031197 0.6 dbSUPER 23.9 +40.5 40545 3 NRF1 ZSCAN4 BHLHE40 MNT ZNF384 FOXK2 POLR2A MYNN KDM1A NKAIN1 SERINC2 SNRNP40 ZCCHC17 ENSG00000229044 GC01M031217 RPL21P22
GH01H031201 0.4 dbSUPER 31.3 +37.8 37835 1 RFX1 POLR2A NKAIN1 SERINC2 ENSG00000229044 GC01M031217 RPL21P22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NKAIN1 on UCSC Golden Path with GeneCards custom track

Promoters for NKAIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004166 187 601 MXI1 KLF1 ZNF76 KLF17 ZIC2 HIC1 GLIS2 POLR2A ZBTB48 PATZ1

Genomic Location for NKAIN1 Gene

Chromosome:
1
Start:
31,179,745 bp from pter
End:
31,239,887 bp from pter
Size:
60,143 bases
Orientation:
Minus strand

Genomic View for NKAIN1 Gene

Genes around NKAIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAIN1 Gene

Proteins for NKAIN1 Gene

  • Protein details for NKAIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMZ8-NKAI1_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
    Protein Accession:
    Q4KMZ8
    Secondary Accessions:
    • A2VDJ3
    • B7Z5F5
    • B7Z5W9
    • Q9H9M7

    Protein attributes for NKAIN1 Gene

    Size:
    207 amino acids
    Molecular mass:
    23552 Da
    Quaternary structure:
    • Interacts with ATP1B1 C-terminus.
    SequenceCaution:
    • Sequence=AAH96707.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH98173.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH98249.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI31519.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14196.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAX07629.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NKAIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKAIN1 Gene

Post-translational modifications for NKAIN1 Gene

  • Glycosylation at posLast=100100
  • Modification sites at PhosphoSitePlus

Other Protein References for NKAIN1 Gene

No data available for DME Specific Peptides for NKAIN1 Gene

Domains & Families for NKAIN1 Gene

Gene Families for NKAIN1 Gene

Protein Domains for NKAIN1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q4KMZ8

UniProtKB/Swiss-Prot:

NKAI1_HUMAN :
  • Belongs to the NKAIN family.
Family:
  • Belongs to the NKAIN family.
genes like me logo Genes that share domains with NKAIN1: view

Function for NKAIN1 Gene

Gene Ontology (GO) - Molecular Function for NKAIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051117 ATPase binding IEA --
genes like me logo Genes that share ontologies with NKAIN1: view
genes like me logo Genes that share phenotypes with NKAIN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NKAIN1

CRISPR Products

miRNA for NKAIN1 Gene

miRTarBase miRNAs that target NKAIN1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NKAIN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKAIN1 Gene

Localization for NKAIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAIN1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKAIN1 gene
Compartment Confidence
plasma membrane 4
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NKAIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NKAIN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NKAIN1 Gene

Pathways & Interactions for NKAIN1 Gene

SuperPathways for NKAIN1 Gene

No Data Available

Interacting Proteins for NKAIN1 Gene

Gene Ontology (GO) - Biological Process for NKAIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002028 regulation of sodium ion transport IBA --
genes like me logo Genes that share ontologies with NKAIN1: view

No data available for Pathways by source and SIGNOR curated interactions for NKAIN1 Gene

Drugs & Compounds for NKAIN1 Gene

No Compound Related Data Available

Transcripts for NKAIN1 Gene

Unigene Clusters for NKAIN1 Gene

Na+/K+ transporting ATPase interacting 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NKAIN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NKAIN1 Gene

No ASD Table

Relevant External Links for NKAIN1 Gene

GeneLoc Exon Structure for
NKAIN1
ECgene alternative splicing isoforms for
NKAIN1

Expression for NKAIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKAIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKAIN1 Gene

This gene is overexpressed in Brain - Cerebellum (x9.4) and Brain - Cerebellar Hemisphere (x8.9).

Protein differential expression in normal tissues from HIPED for NKAIN1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NKAIN1 Gene



Protein tissue co-expression partners for NKAIN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NKAIN1 Gene:

NKAIN1

SOURCE GeneReport for Unigene cluster for NKAIN1 Gene:

Hs.470259

Evidence on tissue expression from TISSUES for NKAIN1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with NKAIN1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKAIN1 Gene

Orthologs for NKAIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKAIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKAIN1 33 34
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia NKAIN1 33 34
  • 95.97 (n)
dog
(Canis familiaris)
Mammalia NKAIN1 33 34
  • 95.77 (n)
oppossum
(Monodelphis domestica)
Mammalia NKAIN1 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkain1 33 16 34
  • 92.59 (n)
rat
(Rattus norvegicus)
Mammalia Nkain1 33
  • 88.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NKAIN1 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKAIN1 33 34
  • 85.01 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nkain1 33
  • 73.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24215 33
zebrafish
(Danio rerio)
Actinopterygii nkain1 33 34
  • 74.72 (n)
zgc65908 33
fruit fly
(Drosophila melanogaster)
Insecta NKAIN 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3479 34
  • 33 (a)
OneToMany
Species where no ortholog for NKAIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKAIN1 Gene

ENSEMBL:
Gene Tree for NKAIN1 (if available)
TreeFam:
Gene Tree for NKAIN1 (if available)

Paralogs for NKAIN1 Gene

Paralogs for NKAIN1 Gene

(4) SIMAP similar genes for NKAIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NKAIN1: view

Variants for NKAIN1 Gene

Sequence variations from dbSNP and Humsavar for NKAIN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000064271 -- 31,205,045(+) ATAAT(A/G)TCTAC intron-variant
rs1000112137 -- 31,241,200(+) AAACC(C/T)CATCT upstream-variant-2KB
rs1000140596 -- 31,219,900(+) AAGGA(A/G)CAAAT intron-variant
rs1000262796 -- 31,200,089(+) CACAC(A/G)CATTC intron-variant
rs1000303693 -- 31,222,623(+) GGAGA(C/T)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKAIN1 Gene

Variant ID Type Subtype PubMed ID
esv21860 CNV loss 19812545
esv2758930 CNV loss 17122850
nsv1075384 CNV deletion 25765185
nsv1126190 CNV deletion 24896259
nsv1145331 CNV deletion 24896259
nsv160707 CNV deletion 16902084
nsv508711 CNV deletion 20534489

Variation tolerance for NKAIN1 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKAIN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKAIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAIN1 Gene

Disorders for NKAIN1 Gene

Relevant External Links for NKAIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKAIN1

No disorders were found for NKAIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAIN1 Gene

Publications for NKAIN1 Gene

  1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. (PMID: 17606467) Gorokhova S … Heintz N (Human molecular genetics 2007) 2 3 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. (PMID: 23455491) Zuo L … Luo X (Drug and alcohol dependence 2013) 3 60

Products for NKAIN1 Gene

Sources for NKAIN1 Gene

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