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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NKAIN1 Gene

protein-coding   GIFtS: 41
GCID: GC01M031652

Na+/K+ transporting ATPase interacting 1

(Previous names: family with sequence similarity 77, member C )
(Previous symbol: FAM77C)
  Search for NKAIN1
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NKAIN1    

Aliases
for NKAIN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Na+/K+ Transporting ATPase Interacting 11 2     FLJ126501
FAM77C1 2 3     Sodium/Potassium-Transporting ATPase Subunit Beta-1-Interacting Protein 12
Family With Sequence Similarity 77, Member C1 2     Protein FAM77C3
Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein 12 3     

External Ids:    HGNC: 257431   Entrez Gene: 795702   Ensembl: ENSG000000846287   OMIM: 6128715   UniProtKB: Q4KMZ83   

Export aliases for NKAIN1 gene to outside databases

Previous GC identifers: GC01M031426 GC01M029759


Summaries
for NKAIN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NKAIN1:
NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta
subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 (PubMed 17606467)).(supplied by OMIM, Jun 2009)




Genomic Views
for NKAIN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NKAIN1 gene promoter:
         AP-2rep   NRSF form 1   CUTL1   LCR-F1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NKAIN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NKAIN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NKAIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.2   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p35.2

NKAIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKAIN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M031652:  view genomic region     (about GC identifiers)

Start:
 31,652,592 bp from pter      End:
 31,712,734 bp from pter
Size:
 60,143 bases      Orientation:
 minus strand

Proteins
for NKAIN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NKAI1_HUMAN, Q4KMZ8 (See protein sequence)
Recommended Name: Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 precursor  
Size: 207 amino acids; 23552 Da
Subunit: Interacts with ATP1B1 C-terminus (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH96707.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH98173.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH98249.2;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI31519.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB14196.1; Type=Erroneous initiation; Note=Translation N-terminally
extended; Sequence=EAX07629.1; Type=Erroneous gene model prediction;
Secondary accessions: A2VDJ3 B7Z5W9 Q9H9M7

Explore the universe of human proteins at neXtProt for NKAIN1: NX_Q4KMZ8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q4KMZ8

    • NKAIN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_078798.2  
    ENSEMBL proteins: 
     ENSP00000362841   ENSP00000433225   ENSP00000263693   ENSP00000381650  

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    Uscn Proteins for NKAIN1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    NKAIN1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NKAIN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NKAIN1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008516 Na/K-Atpase_Interacting

    Graphical View of Domain Structure for InterPro Entry Q4KMZ8

    ProtoNet protein and cluster: Q4KMZ8

    UniProtKB/Swiss-Prot: NKAI1_HUMAN, Q4KMZ8
    Similarity: Belongs to the NKAIN family


    Function
    for NKAIN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NKAIN1
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate NKAIN1 (see all 32):
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    SwitchGear 3'UTR luciferase reporter plasmid: NKAIN1 3' UTR sequence
    Inhib. RNA
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    Clone
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    2 GenomeRNAi human phenotypes for NKAIN1:
     Decreased TP53 protein express  Increased cell number in S 


    Pathways & Interactions
    for NKAIN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NKAIN1

    Drugs & Compounds
    for NKAIN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NKAIN1
    Search CenterWatch for drugs/clinical trials and news about NKAIN1 / NKAI1 

    Transcripts
    for NKAIN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for NKAIN1 gene: 
    NM_024522.2  

    Unigene Cluster for NKAIN1:

    Na+/K+ transporting ATPase interacting 1
    Hs.470259  [show with all ESTs]
    Unigene Representative Sequence: NM_024522
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373736(uc010ogc.2 uc010ogd.2) ENST00000528449 ENST00000526106
    ENST00000530145 ENST00000533581 ENST00000263693 ENST00000398657

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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate NKAIN1 (see all 32):
    hsa-miR-21* hsa-miR-330-5p hsa-miR-29a hsa-miR-650 hsa-miR-570 hsa-miR-3658 hsa-miR-654-5p hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmid: NKAIN1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK022712.1 AK298874.1 AK299507.1 AL832547.1 BC096707.1 BC098173.1 BC098249.1 BC131518.1 

    2 DOTS entries:

    DT.454229  DT.121403445 

    24/493 AceView cDNA sequences (see all 493):

    BQ270940 AA490361 NM_014676 AL118913 R59383 BF438641 AL043697 CF594043 
    AA978275 C04873 CA976062 AU125707 BU607410 AI057081 BU165981 AA234752 
    BE780206 BE552252 R67272 BQ879853 BQ894616 AI263017 AI370781 T16601 

    GeneLoc Exon Structure


    Expression
    for NKAIN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NKAIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCTCCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NKAIN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See NKAIN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NKAIN1

    SOURCE GeneReport for Unigene cluster: Hs.470259
        SABiosciences Custom PCR Arrays for NKAIN1
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NKAIN1

    Orthologs
    for NKAIN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NKAIN1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NKAIN11 Na+/K+ transporting ATPase interacting 1 85.07(n)
    93.23(a)    		   768785  XM_001231907.2  XP_001231908.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NKAIN16
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343563.1(149736-154585)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.242152 Xenopus laevis transcribed sequence with moderate similarity more 75.63(n)    BJ062104.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc659082 hypothetical protein MGC65908 76.85(n)   393517  BC056509.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta NKAIN1 Na,K-ATPase Interacting 55.37(n)
    46.89(a)    		   37979  NM_001103979.3  NP_001097449.2 


    ENSEMBL Gene Tree for NKAIN1 (if available)
    TreeFam Gene Tree for NKAIN1 (if available) 

    Paralogs
    for NKAIN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NKAIN1 gene
    NKAIN42  NKAIN22  NKAIN32  
    4 SIMAP similar genes for NKAIN1 using alignment to 3 protein entries:     NKAI1_HUMAN (see all proteins):
    TCBA1    NKAIN3    NKAIN2    NKAIN4

    NKAIN1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for NKAIN1
    PGOHUM00000244253 PGOHUM00000240767 PGOHUM00000263256 PGOHUM00000263262 PGOHUM00000263263


    Genomic Variants
    for NKAIN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1364 NCBI SNPs in NKAIN1 are shown (see all 1364)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1412028331,2
    		--31652196(+) TTACAA/GGCCAG 1 -- int10--------
    rs1450237391,2
    		--31652227(+) TTTTAC/TTGTTT 1 -- int10--------
    rs1814976481,2
    		--31652238(+) TGAGAC/TGGAGT 1 -- int10--------
    rs1861757761,2
    		--31652350(+) TGCCTA/CATTTT 1 -- int10--------
    rs1901559531,2
    		--31652449(+) AAAAGC/TGTTGG 1 -- int10--------
    rs10430901,2
    		C--31652754(-) CCTTTC/TTACTC 1 -- ut31 ese32Minor allele frequency- T:0.00MN NA 186
    rs1390153981,2
    		--31652843(+) AGGGAG/TCTGCC 1 -- ut310--------
    rs1147859751,2
    		C,F,--31652885(+) CTCCAT/CGCCTG 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1833956071,2
    		--31652916(+) GGGCCC/TGGCTG 1 -- ut310--------
    rs1155717381,2
    		--31653174(+) TGGACG/CCACCA 1 -- ut311Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for NKAIN1 (31652592 - 31712734 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NKAIN1: --

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    Disorders / Diseases
    for NKAIN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NKAIN1 for disorders           About MalaCards

    NKAIN1 for disorders           About GeneDecksing

    OMIM gene information: 612871    OMIM disorders: --


    Export disorders for NKAIN1 gene to outside databases

    Publications
    for NKAIN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NKAIN1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NKAIN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. (PubMed id 17606467)1, 3 Gorokhova S....Heintz N. (2007)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for NKAIN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NKAIN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79570 HGNC: 25743 AceView: PUM1andFLJ12650 Ensembl:ENSG00000084628 euGenes: HUgn79570
    ECgene: NKAIN1 H-InvDB: NKAIN1

    Other Databases showing NKAIN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NKAIN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NKAIN1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NKAIN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NKAIN1 gene:
    Search GeneIP for patents involving NKAIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NKAIN1 gene

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