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Aliases for NKAIN1 Gene

Aliases for NKAIN1 Gene

  • Na+/K+ Transporting ATPase Interacting 1 2 3 5
  • Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein 1 3 4
  • Family With Sequence Similarity 77, Member C 2 3
  • FAM77C 3 4
  • Sodium/Potassium-Transporting ATPase Subunit Beta-1-Interacting Protein 1 2
  • Protein FAM77C 4

External Ids for NKAIN1 Gene

Previous HGNC Symbols for NKAIN1 Gene

  • FAM77C

Previous GeneCards Identifiers for NKAIN1 Gene

  • GC01M031426
  • GC01M031652
  • GC01M029759

Summaries for NKAIN1 Gene

Entrez Gene Summary for NKAIN1 Gene

  • NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

GeneCards Summary for NKAIN1 Gene

NKAIN1 (Na+/K+ Transporting ATPase Interacting 1) is a Protein Coding gene. An important paralog of this gene is NKAIN4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAIN1 Gene

Genomics for NKAIN1 Gene

Regulatory Elements for NKAIN1 Gene

Promoters for NKAIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NKAIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NKAIN1 Gene

Chromosome:
1
Start:
31,179,745 bp from pter
End:
31,239,887 bp from pter
Size:
60,143 bases
Orientation:
Minus strand

Genomic View for NKAIN1 Gene

Genes around NKAIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAIN1 Gene

Proteins for NKAIN1 Gene

  • Protein details for NKAIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMZ8-NKAI1_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
    Protein Accession:
    Q4KMZ8
    Secondary Accessions:
    • A2VDJ3
    • B7Z5F5
    • B7Z5W9
    • Q9H9M7

    Protein attributes for NKAIN1 Gene

    Size:
    207 amino acids
    Molecular mass:
    23552 Da
    Quaternary structure:
    • Interacts with ATP1B1 C-terminus.
    SequenceCaution:
    • Sequence=AAH96707.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH98173.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH98249.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI31519.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14196.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAX07629.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NKAIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKAIN1 Gene

Proteomics data for NKAIN1 Gene at MOPED

Post-translational modifications for NKAIN1 Gene

  • Glycosylation at Asn 100
  • Modification sites at PhosphoSitePlus

Other Protein References for NKAIN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKAIN1 Gene

Domains & Families for NKAIN1 Gene

Gene Families for NKAIN1 Gene

Protein Domains for NKAIN1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q4KMZ8

UniProtKB/Swiss-Prot:

NKAI1_HUMAN :
  • Belongs to the NKAIN family.
Family:
  • Belongs to the NKAIN family.
genes like me logo Genes that share domains with NKAIN1: view

Function for NKAIN1 Gene

genes like me logo Genes that share phenotypes with NKAIN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NKAIN1

CRISPR Products

miRNA for NKAIN1 Gene

miRTarBase miRNAs that target NKAIN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKAIN1 Gene

Localization for NKAIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAIN1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NKAIN1 Gene COMPARTMENTS Subcellular localization image for NKAIN1 gene
Compartment Confidence
plasma membrane 4
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NKAIN1 Gene

Pathways & Interactions for NKAIN1 Gene

SuperPathways for NKAIN1 Gene

No Data Available

Interacting Proteins for NKAIN1 Gene

Gene Ontology (GO) - Biological Process for NKAIN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NKAIN1 Gene

Drugs & Compounds for NKAIN1 Gene

No Compound Related Data Available

Transcripts for NKAIN1 Gene

Unigene Clusters for NKAIN1 Gene

Na+/K+ transporting ATPase interacting 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NKAIN1 Gene

No ASD Table

Relevant External Links for NKAIN1 Gene

GeneLoc Exon Structure for
NKAIN1
ECgene alternative splicing isoforms for
NKAIN1

Expression for NKAIN1 Gene

mRNA expression in normal human tissues for NKAIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKAIN1 Gene

This gene is overexpressed in Brain - Cerebellum (x9.4) and Brain - Cerebellar Hemisphere (x8.9).

Protein differential expression in normal tissues from HIPED for NKAIN1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NKAIN1 Gene



SOURCE GeneReport for Unigene cluster for NKAIN1 Gene Hs.470259

genes like me logo Genes that share expression patterns with NKAIN1: view

Protein tissue co-expression partners for NKAIN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NKAIN1 Gene

Orthologs for NKAIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKAIN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NKAIN1 35
  • 95.97 (n)
  • 100 (a)
NKAIN1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NKAIN1 35
  • 95.77 (n)
  • 100 (a)
NKAIN1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nkain1 35
  • 92.59 (n)
  • 99.52 (a)
Nkain1 16
Nkain1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NKAIN1 35
  • 99.39 (n)
  • 100 (a)
NKAIN1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nkain1 35
  • 88.89 (n)
  • 93.24 (a)
oppossum
(Monodelphis domestica)
Mammalia NKAIN1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NKAIN1 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKAIN1 35
  • 85.01 (n)
  • 93.65 (a)
NKAIN1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkain1 35
  • 73.27 (n)
  • 82.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24215 35
zebrafish
(Danio rerio)
Actinopterygii nkain1 35
  • 74.72 (n)
  • 80.19 (a)
zgc65908 35
nkain1 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NKAIN 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3479 36
  • 33 (a)
OneToMany
Species with no ortholog for NKAIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKAIN1 Gene

ENSEMBL:
Gene Tree for NKAIN1 (if available)
TreeFam:
Gene Tree for NKAIN1 (if available)

Paralogs for NKAIN1 Gene

Paralogs for NKAIN1 Gene

(4) SIMAP similar genes for NKAIN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NKAIN1: view

Variants for NKAIN1 Gene

Sequence variations from dbSNP and Humsavar for NKAIN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs946882 -- 31,229,861(-) TCATC(A/G)TCTCA intron-variant
rs946883 -- 31,199,914(-) CATCA(A/G)CTCAT intron-variant
rs946884 -- 31,199,854(-) AGGAT(A/C)CACGC intron-variant
rs946885 -- 31,199,619(-) GGAGC(A/G)CCTCC intron-variant
rs946886 -- 31,199,596(-) CACTG(C/G)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NKAIN1 Gene

Variant ID Type Subtype PubMed ID
nsv508711 CNV Loss 20534489
nsv870772 CNV Loss 21882294
nsv870693 CNV Loss 21882294
nsv160707 CNV Loss 16902084
dgv46e1 CNV Complex 17122850
esv21860 CNV Loss 19812545

Variation tolerance for NKAIN1 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NKAIN1 Gene

HapMap Linkage Disequilibrium report
NKAIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAIN1 Gene

Disorders for NKAIN1 Gene

Relevant External Links for NKAIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NKAIN1

No disorders were found for NKAIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAIN1 Gene

Publications for NKAIN1 Gene

  1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. (PMID: 17606467) Gorokhova S. … Heintz N. (Hum. Mol. Genet. 2007) 2 3 67
  2. NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. (PMID: 23455491) Zuo L. … Luo X. (Drug Alcohol Depend 2013) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for NKAIN1 Gene

Sources for NKAIN1 Gene

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