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NIT2 Gene

protein-coding   GIFtS: 54
GCID: GC03P100053

Nitrilase Family, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nitrilase Family, Member 21 2     Nit Protein 22
Nitrilase Homolog 22 3     Omega-Amidase NIT22
HEL-S-8a2     EC 3.5.1.33
Epididymis Secretory Sperm Binding Protein Li 8a2     

External Ids:    HGNC: 298781   Entrez Gene: 569542   Ensembl: ENSG000001140217   UniProtKB: Q9NQR43   

Export aliases for NIT2 gene to outside databases

Previous GC identifers: GC03M096559 GC03P099332 GC03P101334 GC03P101374 GC03P101536 GC03P097421


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NIT2 Gene:
NIT2 (nitrilase family, member 2) is a protein-coding gene. Diseases associated with NIT2 include down syndrome, and tuberculosis. GO annotations related to this gene include omega-amidase activity.

UniProtKB/Swiss-Prot: NIT2_HUMAN, Q9NQR4
Function: Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by
converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and
oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting
cells in the G2 phase of the cell cycle




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NIT2 gene promoter:
         AML1a   Tal-1beta   PPAR-gamma1   c-Rel   POU2F1   POU2F1a   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNIT2 promoter sequence
   Search Chromatin IP Primers for NIT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NIT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.2   Ensembl cytogenetic band:  3q12.2   HGNC cytogenetic band: 3q12.3

NIT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NIT2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P100053:  view genomic region     (about GC identifiers)

Start:
100,053,545 bp from pter      End:
100,075,710 bp from pter
Size:
22,166 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NIT2_HUMAN, Q9NQR4 (See protein sequence)
Recommended Name: Omega-amidase NIT2  
Size: 276 amino acids; 30608 Da
Subunit: Homodimer
Mass spectrometry: Mass=30585; Method=MALDI; Range=1-276; Source=PubMed:17488281;
Secondary accessions: B2R9A3 D3DN47 Q8WUF0

Explore the universe of human proteins at neXtProt for NIT2: NX_Q9NQR4

Explore proteomics data for NIT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NIT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064587.1  
    ENSEMBL proteins: 
     ENSP00000377696   ENSP00000419157   ENSP00000419239   ENSP00000419189  

    NIT2 Human Recombinant Protein Products:

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    Novus Biologicals NIT2 Proteins
    Novus Biologicals NIT2 Lysate
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    ProSpec Recombinant Protein for NIT2
    Cloud-Clone Corp. Proteins for NIT2

    NIT2 Antibody Products:

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    NIT2 Assay Products:

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    Cloud-Clone Corp. ELISAs for NIT2
    Cloud-Clone Corp. CLIAs for NIT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003010 C-N_Hydrolase

    Graphical View of Domain Structure for InterPro Entry Q9NQR4

    ProtoNet protein and cluster: Q9NQR4

    1 Blocks protein domain: IPB003010 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase

    UniProtKB/Swiss-Prot: NIT2_HUMAN, Q9NQR4
    Similarity: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family
    Similarity: Contains 1 CN hydrolase domain


    NIT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NIT2_HUMAN, Q9NQR4
    Function: Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by
    converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and
    oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting
    cells in the G2 phase of the cell cycle
    Catalytic activity: A monoamide of a dicarboxylic acid + H(2)O = a dicarboxylate + NH(3)
    Biophysicochemical properties: Kinetic parameters: KM=0.009 mM for alpha-ketoglutaramate (open-chain form);
    Vmax=5.9 umol/min/mg enzyme with alpha-ketoglutaramate as substrate; Note=In solution, alpha-ketoglutaramate is
    in equilibrium with a cyclic form (2-hydroxy-5-oxoproline), and at pH 8.0 or above, the rate of ring opening is
    no longer limiting for the omega- amidase reaction;

         Enzyme Number (IUBMB): EC 3.5.1.31

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0050152omega-amidase activity IEA--
         
    NIT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NIT2:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Nit2 (no phenotypes)

    NIT2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nit2tm1Lex for NIT2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NIT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NIT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NIT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NIT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NIT2:
    hsa-mir-320a (MIRT044603)

    Block miRNA regulation of human, mouse, rat NIT2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NIT2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NIT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NIT2

    Clone
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    OriGene clones in human, mouse for NIT2 (see all 6)
    OriGene ORF clones in mouse, rat for NIT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NIT2 (NM_020202)
    Sino Biological Human cDNA Clone for NIT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NIT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIT2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NIT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NIT2_HUMAN, Q9NQR4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    mitochondrion3
    nucleus2
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005813centrosome IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    NIT2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NIT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Alanine, aspartate and glutamate metabolism
    Alanine, aspartate and glutamate metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for NIT2):
        Alanine, aspartate and glutamate metabolism


    NIT2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NIT2: 
              Amino Acid Metabolism I in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NIT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for NIT2 (Q9NQR43 ENSP000003776964) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CNBPP626333I2D: score=1 
    HSP90AA1P079003I2D: score=1 
    PSMD14O004873I2D: score=1 
    GLUD1ENSP000002778654STRING: ENSP00000277865
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006807nitrogen compound metabolic process IEA--
    GO:0008150biological_process ND--

    NIT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NIT2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NIT2 gene: 
    NM_020202.4  

    Unigene Cluster for NIT2:

    Nitrilase family, member 2
    Hs.439152  [show with all ESTs]
    Unigene Representative Sequence: AK295835
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394140(uc003dtv.3) ENST00000465368 ENST00000478856(uc011bha.1)
    ENST00000480073 ENST00000460317 ENST00000497785 ENST00000472392
    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate NIT2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NIT2
    Predesigned siRNA for gene silencing in human, mouse, rat NIT2
    Clone
    Products:
         
    OriGene clones in human, mouse for NIT2 (see all 6)
    OriGene ORF clones in mouse, rat for NIT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NIT2 (NM_020202)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NIT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIT2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NIT2
    OriGene qSTAR qPCR primer pairs in human, mouse for NIT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NIT2
      QuantiTect SYBR Green Assays in human, mouse, rat NIT2
      QuantiFast Probe-based Assays in human, mouse, rat NIT2

    Additional mRNA sequence: 

    AF260334.1 AF284574.1 AJ293397.1 AK225979.1 AK294010.1 AK295835.1 AK313704.1 BC020620.1 
    BC107890.1 

    11 DOTS entries:

    DT.86840966  DT.95283275  DT.100746849  DT.75117739  DT.92434537  DT.100035823  DT.120874169  DT.97844800 
    DT.100812014  DT.95283295  DT.92434539 

    Selected AceView cDNA sequences (see all 215):

    CA311335 BM888473 CA431363 AA315472 BM706082 BF476154 BM845906 BG697846 
    BE734315 N72246 AI222479 BM846039 BM542387 AW954831 BG289591 BM470933 
    AA724263 AA825396 AW016433 CA424702 BU621063 BI761091 AI343549 BM547991 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NIT2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -                       -                                                         
    SP2:                    -                       -                                                         
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for NIT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NIT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGTTTGCAG
    NIT2 Expression
    About this image

    NIT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NIT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439152

    UniProtKB/Swiss-Prot: NIT2_HUMAN, Q9NQR4
    Tissue specificity: Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta,
    lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small
    intestine and colon

        Pathway & Disease-focused RT2 Profiler PCR Array including NIT2: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
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    OriGene qSTAR qPCR primer pairs in human, mouse for NIT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NIT2
    QuantiTect SYBR Green Assays in human, mouse, rat NIT2
    QuantiFast Probe-based Assays in human, mouse, rat NIT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NIT2 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nit21 , 5 nitrilase family, member 21, 5 87.68(n)1
    89.49(a)1
      16 (34.22 cM)5
    526331  NM_023175.11  NP_075664.11 
     571566715 
    chicken
    (Gallus gallus)
    Aves NIT21 nitrilase family, member 2 76.85(n)
    81.45(a)
      418386  XM_416604.4  XP_416604.4 
    lizard
    (Anolis carolinensis)
    Reptilia NIT26
    nitrilase family, member 2
    75(a)
    1 ↔ 1
    3(174205448-174222124)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.47742 Xenopus laevis transcribed sequence with moderate similarity more 77.39(n)    CA971586.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271782 Danio rerio clone RK139A2D11 Nit protein 2 (NIT2) mRNA, more 76.19(n)    AY398388.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81321 , 3 nitrilase3
    CG81321
    53(a)3
    57.81(n)1
    54.24(a)1
      85D153
    411211  NM_141631.21  NP_649888.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NIT31 NIT3 53.68(n)
    51.31(a)
      851065   NP_013455.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G120401 AT5G12040 57.07(n)
    59.41(a)
      831077  NM_121242.4  NP_196765.2 
    rice
    (Oryza sativa)
    Liliopsida Os.191942 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.62(n)    AK059981.1 


    ENSEMBL Gene Tree for NIT2 (if available)
    TreeFam Gene Tree for NIT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NIT2 gene
    1 SIMAP similar gene for NIT2 using alignment to 4 protein entries:     NIT2_HUMAN (see all proteins):
    NIT1

    NIT2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NIT2
    PGOHUM00000244075


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NIT2 (see all 538)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386884251,2
    C--100051635(+) TCTAAC/TGGCTC 1 -- us2k10--------
    rs1162380681,2
    F--100051647(+) TTCCCA/TGGCTC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1882231251,2
    --100051692(+) ACTCCA/GCTTGT 1 -- us2k10--------
    rs738624511,2
    C,F--100051694(+) TCCGCT/CTGTGT 1 -- us2k13Minor allele frequency- C:0.04WA CSA 122
    rs1927280881,2
    --100051724(+) GCTTCC/TTCTTA 1 -- us2k10--------
    rs1842544961,2
    --100051727(+) TCCTCG/TTAGTT 1 -- us2k10--------
    rs1876640091,2
    --100051729(+) CTCTTA/GGTTAA 1 -- us2k10--------
    rs1923996391,2
    --100051745(+) CTGGTA/GACTCC 1 -- us2k10--------
    rs1848399501,2
    --100051778(+) ATCTTC/TTGAGC 1 -- us2k10--------
    rs1895643231,2
    --100051892(+) AGCCTA/GGGAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NIT2 (100053545 - 100075710 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NIT2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NIT2
    DNA2.0 Custom Variant and Variant Library Synthesis for NIT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for NIT2:    
    About MalaCards
    down syndrome    tuberculosis    malaria    prostatitis


    NIT2 for disorders           About GeneDecksing


    Export disorders for NIT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NIT2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with NIT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of the worm NitFhit Rosetta stone protein reveals a Nit tetramer binding two Fhit dimers. (PubMed id 10959838)1, 2, 3 Pace H.C.... Brenner C. (Curr. Biol. 2000)
    2. Growth inhibitory effect of the human NIT2 gene and its allelic imbalance in cancers. (PubMed id 17488281)1, 2, 9 Lin C.-H.... Chien C.-H. (FEBS J. 2007)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Structural insights into the catalytic active site and activity of human Nit2/I8-amidase: kinetic assay and molecular dynamics simulation. (PubMed id 22674578)1 Chien C.H....Sheu S.Y. (J. Biol. Chem. 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. Identification of the putative tumor suppressor Nit2 as omega- amidase, an enzyme metabolically linked to glutamine and asparagine transamination. (PubMed id 19595734)2 Krasnikov B.F.... Cooper A.J.L. (Biochimie 2009)
    9. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56954 HGNC: 29878 AceView: NIT2 Ensembl:ENSG00000114021 euGenes: HUgn56954
    ECgene: NIT2 Kegg: 56954 H-InvDB: NIT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NIT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NIT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NIT2 gene:
    Search GeneIP for patents involving NIT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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