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NIT1 Gene

protein-coding   GIFtS: 54
GCID: GC01P161087

Nitrilase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nitrilase 11 2
Nitrilase Homolog 12
EC 3.5.-.-3

External Ids:    HGNC: 78281   Entrez Gene: 48172   Ensembl: ENSG000001587937   OMIM: 6046185   UniProtKB: Q86X763   

Export aliases for NIT1 gene to outside databases

Previous GC identifers: GC01P158799 GC01P156820 GC01P157865 GC01P158304 GC01P157900 GC01P159355 GC01P132445


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NIT1 Gene:
This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases,
enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for NIT1 Gene:
NIT1 (nitrilase 1) is a protein-coding gene. GO annotations related to this gene include nitrilase activity.

UniProtKB/Swiss-Prot: NIT1_HUMAN, Q86X76
Function: Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA
damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this
effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.
Has apparently no omega-amidase activity such as NIT2 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NIT1 gene promoter:
         HOXA9B   HOXA9   p53   GATA-3   NRSF form 1   MIF-1   NRSF form 2   Egr-2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNIT1 promoter sequence
   Search Chromatin IP Primers for NIT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q21-q22

NIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NIT1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161087:  view genomic region     (about GC identifiers)

Start:
161,087,862 bp from pter      End:
161,095,235 bp from pter
Size:
7,374 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NIT1_HUMAN, Q86X76 (See protein sequence)
Recommended Name: Nitrilase homolog 1  
Size: 327 amino acids; 35896 Da
Miscellaneous: According to Rosetta Stone theory, the existence of a fusion protein in one genome predicts that
the separate polypeptides expressed in other organisms function in the same cellular or biochemical pathway. In
Drosophila melanogaster and Caenorhabditis elegans, NitFhit is a fusion protein composed of a C-terminal Fhit
domain and a domain related to plant and bacterial nitrilase
Secondary accessions: B1AQP3 D3DVF4 O76091
Alternative splicing: 5 isoforms:  Q86X76-1   Q86X76-2   Q86X76-3   Q86X76-4   Q86X76-5   (Based on a naturally occurring readthrough transcript which produces a NIT1-DEDD fusion protein. The last 4 amino acids of this isoform (PVSS) are encoded by the last DEDD exon. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NIT1: NX_Q86X76

Explore proteomics data for NIT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NIT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001172021.1  NP_001172022.1  NP_001172023.1  NP_005591.1  

    ENSEMBL proteins: 
     ENSP00000356988   ENSP00000356987   ENSP00000356986   ENSP00000376028  

    NIT1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NIT1

     
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    antibodies-online proteins for NIT1 (7 products) 

     
    antibodies-online peptides for NIT1

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    antibodies-online antibodies for NIT1 (38 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003010 C-N_Hydrolase
     IPR001110 UPF0012_CS

    Graphical View of Domain Structure for InterPro Entry Q86X76

    ProtoNet protein and cluster: Q86X76

    2 Blocks protein domains:
    IPB001110 Protein of unknown function UPF0012
    IPB003010 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase


    UniProtKB/Swiss-Prot: NIT1_HUMAN, Q86X76
    Similarity: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family
    Similarity: Contains 1 CN hydrolase domain


    Find genes that share domains with NIT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NIT1_HUMAN, Q86X76
    Function: Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA
    damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this
    effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.
    Has apparently no omega-amidase activity such as NIT2 (By similarity)

         Enzyme Number (IUBMB): EC 3.5.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000257nitrilase activity TAS9671749
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
         
    Find genes that share ontologies with NIT1           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nit1):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  integument  normal 
     tumorigenesis 

    Find genes that share phenotypes with NIT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NIT1: Nit1tm1Lex Nit1tm1.1Hbn

       genOway: Develop your customized and physiologically relevant rodent model for NIT1

    miRNA
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    miRTarBase miRNAs that target NIT1:
    hsa-mir-224-5p (MIRT003233)

    Block miRNA regulation of human, mouse, rat NIT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NIT1 (see all 17):
    hsa-miR-1321 hsa-miR-875-3p hsa-miR-125a-3p hsa-miR-512-3p hsa-miR-4325 hsa-miR-1299 hsa-miR-3163 hsa-miR-3659
    SwitchGear 3'UTR luciferase reporter plasmidNIT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NIT1
    Predesigned siRNA for gene silencing in human, mouse, rat NIT1

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    GenScript: all cDNA clones in your preferred vector (see all 4): NIT1 (NM_005600)
    Sino Biological Human cDNA Clone for NIT1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NIT1_HUMAN, Q86X76: Cytoplasm. Mitochondrion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    endoplasmic reticulum1
    extracellular1
    lysosome1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with NIT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NIT1
    Interactions:

        Search GeneGlobe Interaction Network for NIT1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for NIT1 (Q86X762, 3 ENSP000003569884) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFYVE9O954052, 3MINT-62057 I2D: score=3 
    XRCC6P129563, ENSP000003522574I2D: score=4 STRING: ENSP00000352257
    ATG101Q9BSB43I2D: score=1 
    CYC1P085743I2D: score=1 
    HSP90AA1P079003I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006807nitrogen compound metabolic process IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with NIT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NIT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NIT1 gene (4 alternative transcripts): 
    NM_001185092.1  NM_001185093.1  NM_001185094.1  NM_005600.2  

    Unigene Cluster for NIT1:

    Nitrilase 1
    Hs.146406  [show with all ESTs]
    Unigene Representative Sequence: NM_001185092
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496768 ENST00000368009 ENST00000479266 ENST00000477684 ENST00000486962
    ENST00000492411 ENST00000368008(uc001fxw.3) ENST00000473918 ENST00000478277
    ENST00000496861 ENST00000491497 ENST00000485594 ENST00000461376 ENST00000479728
    ENST00000368007(uc010pka.2) ENST00000392190(uc001fxv.2 uc001fxy.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat NIT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NIT1 (see all 17):
    hsa-miR-1321 hsa-miR-875-3p hsa-miR-125a-3p hsa-miR-512-3p hsa-miR-4325 hsa-miR-1299 hsa-miR-3163 hsa-miR-3659
    SwitchGear 3'UTR luciferase reporter plasmidNIT1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NIT1
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    GenScript: all cDNA clones in your preferred vector (see all 4): NIT1 (NM_005600)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIT1
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    OriGene qPCR primer pairs and template standards for NIT1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NIT1
      QuantiTect SYBR Green Assays in human, mouse, rat NIT1
      QuantiFast Probe-based Assays in human, mouse, rat NIT1

    Additional mRNA sequence: 

    AF069987.1 AK296606.1 AK313323.1 BC046149.1 CR541814.1 CR541846.1 

    Selected DOTS entries (see all 27):

    DT.100878742  DT.95171244  DT.100878736  DT.95171160  DT.70102677  DT.100878738  DT.100839476  DT.121398618 
    DT.449341  DT.100878721  DT.121398561  DT.121398575  DT.92449686  DT.99980132  DT.100878720  DT.121398636 
    DT.97808063  DT.100038735  DT.100878722  DT.100878728  DT.100878729  DT.100878735  DT.121398563  DT.92449679 

    Selected AceView cDNA sequences (see all 305):

    BM975958 AA766114 CR622990 CA428870 BM725052 BE858849 BU677808 AI126753 
    BM451299 BM142010 BI711712 CR609891 AA293338 BQ441752 CR606194 AW342087 
    BQ059007 BM141822 BM666784 AA399464 BP338570 AA723708 AA931782 CR626659 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NIT1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b
    SP1:              -     -     -     -     -                 -                                                                           
    SP2:                          -     -     -                 -                                                                           
    SP3:              -     -     -     -     -     -           -                                                                           
    SP4:                                                        -                                                                           
    SP5:              -     -     -     -     -     -     -     -                                                                           


    ECgene alternative splicing isoforms for NIT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NIT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACTGAAG
    NIT1 Expression
    About this image

    NIT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NIT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146406

    UniProtKB/Swiss-Prot: NIT1_HUMAN, Q86X76
    Tissue specificity: Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas

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    QuantiFast Probe-based Assays in human, mouse, rat NIT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NIT1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nit11 , 5 nitrilase 11, 5 87.1(n)1
    85.45(a)1
      1 (79.35 cM)5
    270451  NM_012049.21  NP_036179.11 
     1713380085 
    chicken
    (Gallus gallus)
    Aves NIT11 nitrilase 1 66.34(n)
    65.91(a)
      429566  XM_003642703.2  XP_003642751.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Nit12 Nit protein 1 75.72(n)    AF284575.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.160222 Transcribed sequence with weak similarity to protein more 71.08(n)    BG737861.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NitFhit3 nitrilase 48(a)   61B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea nft-13   -- 50(a)   III(11995535-12000978)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NIT2(YJL126W)4
    NIT21
    Nit protein, one of two proteins in S. cerevisiae with more4
    NIT21
    47.17(n)1
    40.79(a)1
      10(184501-185424)4
    8533161, 4  NP_012409.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G087901 AT4G08790 52.75(n)
    48.28(a)
      826449  NM_116949.3  NP_567340.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g05025001 Os12g0502500 51.72(n)
    47.69(a)
      4352282  NM_001073362.2  NP_001066830.1 


    ENSEMBL Gene Tree for NIT1 (if available)
    TreeFam Gene Tree for NIT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NIT1 gene
    1 SIMAP similar gene for NIT1 using alignment to 1 protein entry:     NIT1_HUMAN:
    NIT2

    Find genes that share paralogs with NIT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NIT1 (see all 21)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710903661,2
    C--161089452(-) GAATCTAAGTT/-
            
    TAGGT
    1 -- cds11Minor allele frequency- -:0.00NA 2
    rs1926453351,2
    C--161089886(+) CTGTTC/TTTCAT 4 -- int10--------
    rs2016444031,2
    C--161089996(+) TTGGAA/TCCATT 8 T S mis10--------
    rs1448216691,2
    C,F--161089997(+) TGGATC/GCATTA 8 S C mis11Minor allele frequency- G:0.00NA 4550
    rs1488189901,2
    F--161090010(+) GGCCCA/CGCCCA 8 P syn11Minor allele frequency- C:0.00NA 4550
    rs2019711491,2
    --161090011(+) GCCCAC/GCCCAC 8 P A mis10--------
    rs2009828591,2
    --161090034(+) TGATGA/CCTTTT 4 -- int10--------
    rs767296211,2
    C,F--161090077(+) TCCCCC/GCTTGG 4 -- int12Minor allele frequency- G:0.06NA EU 1421
    rs1875544911,2
    --161090100(+) AATTCC/TTTCCC 4 -- int10--------
    rs1920306021,2
    --161090231(+) CTCACC/TTGTCA 4 -- int10--------

    HapMap Linkage Disequilibrium report for NIT1 (161087862 - 161095235 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NIT1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NIT1
    DNA2.0 Custom Variant and Variant Library Synthesis for NIT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604618    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for NIT1:
    Diabetes mellitus     Insulinoma

    Find genes that share disorders with NIT1           About GenesLikeMe

    1 Novoseek inferred disease relationship for NIT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 16864578 (1), 19395373 (1)

    Genetic Association Database (GAD): NIT1
    Human Genome Epidemiology (HuGE) Navigator: NIT1 (1 document)

    Export disorders for NIT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NIT1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with NIT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. (PubMed id 9671749)1, 2, 3, 9 Pekarsky Y.... Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor. (PubMed id 16864578)1, 9 Semba S....Huebner K. (J. Biol. Chem. 2006)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4817 HGNC: 7828 AceView: NIT1 Ensembl:ENSG00000158793 euGenes: HUgn4817
    ECgene: NIT1 H-InvDB: NIT1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NIT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NIT1 gene:
    Search GeneIP for patents involving NIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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