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Aliases for NIT1 Gene

Aliases for NIT1 Gene

  • Nitrilase 1 2 3
  • EC 3.5.-.- 4

External Ids for NIT1 Gene

Previous GeneCards Identifiers for NIT1 Gene

  • GC01P158799
  • GC01P156820
  • GC01P157865
  • GC01P158304
  • GC01P157900
  • GC01P159355
  • GC01P161087
  • GC01P132445

Summaries for NIT1 Gene

Entrez Gene Summary for NIT1 Gene

  • This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for NIT1 Gene

NIT1 (Nitrilase 1) is a Protein Coding gene. GO annotations related to this gene include nitrilase activity.

UniProtKB/Swiss-Prot for NIT1 Gene

  • Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIT1 Gene

Genomics for NIT1 Gene

Regulatory Elements for NIT1 Gene

Genomic Location for NIT1 Gene

Start:
161,118,072 bp from pter
End:
161,125,445 bp from pter
Size:
7,374 bases
Orientation:
Plus strand

Genomic View for NIT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIT1 Gene

Proteins for NIT1 Gene

  • Protein details for NIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X76-NIT1_HUMAN
    Recommended name:
    Nitrilase homolog 1
    Protein Accession:
    Q86X76
    Secondary Accessions:
    • B1AQP3
    • D3DVF4
    • O76091

    Protein attributes for NIT1 Gene

    Size:
    327 amino acids
    Molecular mass:
    35896 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to Rosetta Stone theory, the existence of a fusion protein in one genome predicts that the separate polypeptides expressed in other organisms function in the same cellular or biochemical pathway. In Drosophila melanogaster and Caenorhabditis elegans, NitFhit is a fusion protein composed of a C-terminal Fhit domain and a domain related to plant and bacterial nitrilase

    Alternative splice isoforms for NIT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NIT1 Gene

Proteomics data for NIT1 Gene at MOPED

Post-translational modifications for NIT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NIT1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NIT1

No data available for DME Specific Peptides for NIT1 Gene

Domains for NIT1 Gene

Suggested Antigen Peptide Sequences for NIT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86X76

UniProtKB/Swiss-Prot:

NIT1_HUMAN :
  • Q86X76
Domain:
  • Contains 1 CN hydrolase domain.
Family:
  • Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
genes like me logo Genes that share domains with NIT1: view

No data available for Gene Families for NIT1 Gene

Function for NIT1 Gene

Molecular function for NIT1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity).

Enzyme Numbers (IUBMB) for NIT1 Gene

Gene Ontology (GO) - Molecular Function for NIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000257 nitrilase activity TAS 9671749
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds --
genes like me logo Genes that share ontologies with NIT1: view
genes like me logo Genes that share phenotypes with NIT1: view

Animal Models for NIT1 Gene

MGI Knock Outs for NIT1:

Animal Model Products

miRNA for NIT1 Gene

miRTarBase miRNAs that target NIT1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIT1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for NIT1 Gene

Localization for NIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIT1 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIT1 Gene COMPARTMENTS Subcellular localization image for NIT1 gene
Compartment Confidence
mitochondrion 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NIT1: view

Pathways for NIT1 Gene

SuperPathways for NIT1 Gene

No Data Available

Interacting Proteins for NIT1 Gene

Gene Ontology (GO) - Biological Process for NIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006807 nitrogen compound metabolic process IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NIT1: view

No data available for Pathways by source for NIT1 Gene

Transcripts for NIT1 Gene

Unigene Clusters for NIT1 Gene

Nitrilase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - - - - - -
SP9: - -
SP10:

Relevant External Links for NIT1 Gene

GeneLoc Exon Structure for
NIT1
ECgene alternative splicing isoforms for
NIT1

Expression for NIT1 Gene

mRNA expression in normal human tissues for NIT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NIT1 Gene

SOURCE GeneReport for Unigene cluster for NIT1 Gene Hs.146406

mRNA Expression by UniProt/SwissProt for NIT1 Gene

Q86X76-NIT1_HUMAN
Tissue specificity: Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with NIT1: view

Expression partners for NIT1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for NIT1 Gene

Orthologs for NIT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NIT1 35
  • 91.85 (n)
  • 90.21 (a)
NIT1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIT1 35
  • 91.95 (n)
  • 92.97 (a)
NIT1 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nit1 35
  • 87.1 (n)
  • 85.45 (a)
Nit1 16
Nit1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NIT1 35
  • 99.39 (n)
  • 98.78 (a)
NIT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nit1 35
  • 87.58 (n)
  • 86.65 (a)
oppossum
(Monodelphis domestica)
Mammalia NIT1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves NIT1 35
  • 66.34 (n)
  • 65.91 (a)
NIT1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nit1 35
  • 64.53 (n)
  • 61.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia Nit1 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16022 35
nit1 35
  • 58.07 (n)
  • 57.95 (a)
nit1 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NitFhit 37
  • 48 (a)
NitFhit 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nft-1 37
  • 50 (a)
nft-1 36
  • 32 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15247g 35
  • 44.89 (n)
  • 37.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIT2 35
  • 47.17 (n)
  • 40.79 (a)
NIT2 36
  • 35 (a)
OneToOne
NIT2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G08790 35
  • 52.75 (n)
  • 48.28 (a)
rice
(Oryza sativa)
Liliopsida Os12g0502500 35
  • 51.72 (n)
  • 47.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05757 35
  • 50.18 (n)
  • 46.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC651.02 35
  • 50.75 (n)
  • 45.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for NIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIT1 Gene

ENSEMBL:
Gene Tree for NIT1 (if available)
TreeFam:
Gene Tree for NIT1 (if available)

Paralogs for NIT1 Gene

Selected SIMAP similar genes for NIT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NIT1: view

No data available for Paralogs for NIT1 Gene

Variants for NIT1 Gene

Sequence variations from dbSNP and Humsavar for NIT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs76729621 -- 161,120,287(+) TCCCC(C/G)CTTGG intron-variant
rs139417894 -- 161,120,217(+) ACAGG(C/T)CCAGC reference, synonymous-codon
rs144821669 -- 161,120,207(+) TGGAT(C/G)CATTA reference, missense
rs147269138 -- 161,120,168(+) TCAAG(C/G)TGGAG reference, missense
rs148079618 -- 161,120,113(+) TTGGT(A/C)TAGCT missense, reference

Relevant External Links for NIT1 Gene

HapMap Linkage Disequilibrium report
NIT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NIT1 Gene

Disorders for NIT1 Gene

(2) University of Copenhagen DISEASES for NIT1 Gene

(1) Novoseek inferred disease relationships for NIT1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for NIT1

Genetic Association Database (GAD)
NIT1
Human Genome Epidemiology (HuGE) Navigator
NIT1
genes like me logo Genes that share disorders with NIT1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for NIT1 Gene

Publications for NIT1 Gene

  1. Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. (PMID: 9671749) Pekarsky Y. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor. (PMID: 16864578) Semba S. … Huebner K. (J. Biol. Chem. 2006) 3 23
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for NIT1 Gene

Sources for NIT1 Gene

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