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Aliases for NIT1 Gene

Aliases for NIT1 Gene

  • Nitrilase 1 2 3 5
  • EC 3.5.-.- 4

External Ids for NIT1 Gene

Previous GeneCards Identifiers for NIT1 Gene

  • GC01P158799
  • GC01P156820
  • GC01P157865
  • GC01P158304
  • GC01P157900
  • GC01P159355
  • GC01P161087
  • GC01P132445

Summaries for NIT1 Gene

Entrez Gene Summary for NIT1 Gene

  • This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for NIT1 Gene

NIT1 (Nitrilase 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and nitrilase activity.

UniProtKB/Swiss-Prot for NIT1 Gene

  • Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIT1 Gene

Genomics for NIT1 Gene

Regulatory Elements for NIT1 Gene

Enhancers for NIT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NIT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NIT1 Gene

Chromosome:
1
Start:
161,118,072 bp from pter
End:
161,125,445 bp from pter
Size:
7,374 bases
Orientation:
Plus strand

Genomic View for NIT1 Gene

Genes around NIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIT1 Gene

Proteins for NIT1 Gene

  • Protein details for NIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X76-NIT1_HUMAN
    Recommended name:
    Nitrilase homolog 1
    Protein Accession:
    Q86X76
    Secondary Accessions:
    • B1AQP3
    • D3DVF4
    • O76091

    Protein attributes for NIT1 Gene

    Size:
    327 amino acids
    Molecular mass:
    35896 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to Rosetta Stone theory, the existence of a fusion protein in one genome predicts that the separate polypeptides expressed in other organisms function in the same cellular or biochemical pathway. In Drosophila melanogaster and Caenorhabditis elegans, NitFhit is a fusion protein composed of a C-terminal Fhit domain and a domain related to plant and bacterial nitrilase.

    Alternative splice isoforms for NIT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NIT1 Gene

Proteomics data for NIT1 Gene at MOPED

Post-translational modifications for NIT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NIT1 Gene

No data available for DME Specific Peptides for NIT1 Gene

Domains & Families for NIT1 Gene

Suggested Antigen Peptide Sequences for NIT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86X76

UniProtKB/Swiss-Prot:

NIT1_HUMAN :
  • Contains 1 CN hydrolase domain.
  • Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Domain:
  • Contains 1 CN hydrolase domain.
Family:
  • Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
genes like me logo Genes that share domains with NIT1: view

No data available for Gene Families for NIT1 Gene

Function for NIT1 Gene

Molecular function for NIT1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity).

Enzyme Numbers (IUBMB) for NIT1 Gene

genes like me logo Genes that share phenotypes with NIT1: view

Animal Models for NIT1 Gene

MGI Knock Outs for NIT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NIT1

miRNA for NIT1 Gene

miRTarBase miRNAs that target NIT1

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NIT1 Gene

Localization for NIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIT1 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIT1 Gene COMPARTMENTS Subcellular localization image for NIT1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 3
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NIT1 Gene

Pathways & Interactions for NIT1 Gene

SuperPathways for NIT1 Gene

No Data Available

Interacting Proteins for NIT1 Gene

Gene Ontology (GO) - Biological Process for NIT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NIT1 Gene

Drugs & Compounds for NIT1 Gene

No Compound Related Data Available

Transcripts for NIT1 Gene

Unigene Clusters for NIT1 Gene

Nitrilase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NIT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - - - - - -
SP9: - -
SP10:

Relevant External Links for NIT1 Gene

GeneLoc Exon Structure for
NIT1
ECgene alternative splicing isoforms for
NIT1

Expression for NIT1 Gene

mRNA expression in normal human tissues for NIT1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NIT1 Gene



SOURCE GeneReport for Unigene cluster for NIT1 Gene Hs.146406

mRNA Expression by UniProt/SwissProt for NIT1 Gene

Q86X76-NIT1_HUMAN
Tissue specificity: Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with NIT1: view

Protein tissue co-expression partners for NIT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for NIT1 Gene

Orthologs for NIT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NIT1 35
  • 91.85 (n)
  • 90.21 (a)
NIT1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIT1 35
  • 91.95 (n)
  • 92.97 (a)
NIT1 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nit1 35
  • 87.1 (n)
  • 85.45 (a)
Nit1 16
Nit1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NIT1 35
  • 99.39 (n)
  • 98.78 (a)
NIT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nit1 35
  • 87.58 (n)
  • 86.65 (a)
oppossum
(Monodelphis domestica)
Mammalia NIT1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves NIT1 35
  • 66.34 (n)
  • 65.91 (a)
NIT1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nit1 35
  • 64.53 (n)
  • 61.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia Nit1 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16022 35
nit1 35
  • 58.07 (n)
  • 57.95 (a)
nit1 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NitFhit 37
  • 48 (a)
NitFhit 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nft-1 37
  • 50 (a)
nft-1 36
  • 32 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15247g 35
  • 44.89 (n)
  • 37.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIT2 35
  • 47.17 (n)
  • 40.79 (a)
NIT2 36
  • 35 (a)
OneToOne
NIT2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G08790 35
  • 52.75 (n)
  • 48.28 (a)
rice
(Oryza sativa)
Liliopsida Os12g0502500 35
  • 51.72 (n)
  • 47.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05757 35
  • 50.18 (n)
  • 46.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC651.02 35
  • 50.75 (n)
  • 45.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for NIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIT1 Gene

ENSEMBL:
Gene Tree for NIT1 (if available)
TreeFam:
Gene Tree for NIT1 (if available)

Paralogs for NIT1 Gene

(1) SIMAP similar genes for NIT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NIT1: view

No data available for Paralogs for NIT1 Gene

Variants for NIT1 Gene

Sequence variations from dbSNP and Humsavar for NIT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs76729621 -- 161,120,287(+) TCCCC(C/G)CTTGG intron-variant
rs148079618 -- 161,120,113(+) TTGGT(A/C)TAGCT reference, missense
rs139417894 -- 161,120,217(+) ACAGG(C/T)CCAGC reference, synonymous-codon
rs148818990 -- 161,120,220(+) GGCCC(A/C)GCCCA reference, synonymous-codon
rs144821669 -- 161,120,207(+) TGGAT(C/G)CATTA reference, missense

Variation tolerance for NIT1 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.80; 79.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NIT1 Gene

HapMap Linkage Disequilibrium report
NIT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NIT1 Gene

Disorders for NIT1 Gene

Relevant External Links for NIT1

Genetic Association Database (GAD)
NIT1
Human Genome Epidemiology (HuGE) Navigator
NIT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NIT1

No disorders were found for NIT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIT1 Gene

Publications for NIT1 Gene

  1. Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. (PMID: 9671749) Pekarsky Y. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor. (PMID: 16864578) Semba S. … Huebner K. (J. Biol. Chem. 2006) 3 23
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3
  5. Human nitrilase-like protein does not catalyze the hydrolysis of vildagliptin. (PMID: 25008847) Asakura M. … Fujiwara R. (Drug Metab. Pharmacokinet. 2014) 3

Products for NIT1 Gene

Sources for NIT1 Gene

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