NISCH Gene
protein-coding GIFtS: 57
GCID: GC03P052489
|
|
nischarin
| |
Aliases
for NISCH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nischarin1 | | I-1 Receptor Candidate Protein2 3 | | I-11 2 3 | | I1R Candidate Protein2 3 | | IRAS1 2 3 | | Imidazoline Receptor Antisera Selected2 | | KIAA09751 3 | | I1R3 | | Imidazoline Receptor 12 3 | | Imidazoline Receptor Antisera-Selected Protein3 | | IR12 3 | | Imidazoline-1 Receptor3 | | HIRAS1 | | Imidazoline-1 Receptor Candidate Protein3 |
Export aliases for NISCH gene to outside databasesPrevious GC identifers: GC03P051581 GC03P051741 GC03P052345 GC03P052447 GC03P052464 |
Summaries
for NISCH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NISCH:
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the innerlayer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization andcell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapterinsulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes.Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth andmetastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found toaffect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternativesplicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expectedC-terminal domains of a functional imidazoline receptor. (provided by RefSeq, Jan 2013)
UniProtKB/Swiss-Prot: NISCH_HUMAN, Q9Y2I1Function: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator ofthe I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering tocell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylationof mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibitedrilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-inducedmitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulatedsignal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 andinhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 andinhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits alsoLIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migrationand invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed(By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement ofinsulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin tointracellular endosomal structures
Gene Wiki entry for NISCH
|
Genomic Views
for NISCH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NISCH gene promoter:
Max1 Sp1 COUP Olf-1 COUP-TF Pax-4a ATF c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for NISCH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NISCH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.1NISCH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P052489: view genomic region
(about GC identifiers)
Start:
|
52,489,134 bp from pter |
End:
|
52,527,088 bp from pter |
Size:
|
37,955 bases |
Orientation:
|
plus strand |
|
Proteins
for NISCH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NISCH_HUMAN, Q9Y2I1 (See
protein sequence)Recommended Name: Nischarin Size: 1504 amino acids; 166629 Da
Subunit: Homooligomer. Interacts with GRB2. Interacts with PIK3R1; probably associates with the PI3-kinase complex.Interacts with IRS4. Found in a complex with ITGA5 and PAK1. Found in a complex with LIMK1 and PAK1. Interacts withITGA5 (via cytoplasmic domain); this interaction is direct. Interacts with PAK1 (via kinase domain); this interactionis direct and is increased upon activation of PAK1 (By similarity). Interacts with LIMK1 (via PDZ and kinase domain);this interaction is direct (By similarity). Interacts with LIMK2; this interaction depends on LIMK2 activity (Bysimilarity). Interacts with RAC1 (activated state) (By similarity)
Subcellular location: Cell membrane. Cytoplasm. Early endosome. Recycling endosome. Note=Enriched in the early/sortingand recycling endosomes. Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes withtransferrin receptor. Detected in the perinuclear region partially associated with punctate structures (Bysimilarity). Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles (Bysimilarity). Colocalizes with RAC1 in the cytoplasm and vesicles structures (By similarity). Colocalized with MAPK1and MAPK3 in RVLM neurons (By similarity)
Sequence caution: Sequence=BAA76819.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for NISCH:3P0C (3D)
Secondary accessions: C9J245 Q6PGP3 Q6PIB4 Q7L8M3 Q7Z2X6 Q9UES6 Q9UEU4 Q9UFW3Alternative splicing: 4 isoforms: Q9Y2I1-1 Q9Y2I1-2 Q9Y2I1-3 Q9Y2I1-4 Explore the universe of human proteins at neXtProt for NISCH: NX_Q9Y2I1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2I1
NISCH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001263222.1 NP_001263223.1 NP_009115.2
ENSEMBL proteins: ENSP00000418232 ENSP00000417812 ENSP00000392484 ENSP00000339958
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NISCH for ontologies About GeneDecksing
NISCH Antibody Products:
Assay Products for NISCH: |
Protein
Domains /
Families
for NISCH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NISCH for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2I1ProtoNet protein and cluster: Q9Y2I1 1 Blocks protein family: IPB001683 Phox-like
UniProtKB/Swiss-Prot: NISCH_HUMAN, Q9Y2I1Domain: Both the presence of the PX domain and the coiled coil region are necessary for its endosomal targetingSimilarity: Contains 6 LRR (leucine-rich) repeatsSimilarity: Contains 1 PX (phox homology) domain |
Function
for NISCH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NISCH_HUMAN, Q9Y2I1Function: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator ofthe I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering tocell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylationof mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibitedrilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-inducedmitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulatedsignal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 andinhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 andinhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits alsoLIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migrationand invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed(By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement ofinsulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin tointracellular endosomal structures
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NISCH (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NISCH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NISCH (NM_007184) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NISCH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NISCH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NISCH |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005178 | integrin binding |
IEA | -- | | GO:0008227 | G-protein coupled amine receptor activity |
IEA | -- | | GO:0035091 | phosphatidylinositol binding |
IEA | -- |
NISCH for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Nischtm1Lex for NISCH
1 MGI phenotypic allele  for Nisch (no phenotypes)
NISCH for phenotypes About GeneDecksing
|
Pathways & Interactions
for NISCH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion_Integrin-mediated cell adhesion and migration | | | 2 | Hypothetical Network for Drug Addiction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NISCH
1  GeneGo (Thomson Reuters) Pathway for NISCH
1  BioSystems Pathway for NISCH
NISCH for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NISCH
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/10 Interacting proteins for NISCH (Q9Y2I13 ENSP000003399584) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
NISCH for ontologies About GeneDecksing
|
Drugs & Compounds
for NISCH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NISCH for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for NISCH |
 Browse Tocris compounds for NISCH
1 DrugBank Compound for NISCH About this table
10/33 Novoseek chemical compound relationships for NISCH gene (see all 33) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rilmenidine |
96 |
31 |
7998582 (2), 1350732 (2), 1979731 (1), 9284427 (1) (see all 25) |
| moxonidine |
95.9 |
30 |
15028616 (2), 8068579 (1), 8872300 (1), 9284427 (1) (see all 27) |
| idazoxan |
90.2 |
10 |
10415909 (1), 10864097 (1), 8008210 (1), 1355439 (1) (see all 8) |
| agmatine |
88.4 |
24 |
17653850 (4), 9260995 (2), 10415899 (2), 7677340 (1) (see all 16) |
| efaroxan |
87.5 |
2 |
10580423 (1), 12189026 (1) |
| clonidine |
87 |
37 |
1979731 (1), 8096770 (1), 7677340 (1), 8642798 (1) (see all 31) |
| benazoline |
86.7 |
2 |
10825384 (1), 9208095 (1) |
| guanabenz |
80.7 |
5 |
14506596 (1), 7677390 (1), 12189026 (1) |
| cirazoline |
78.6 |
2 |
9116592 (1), 9116583 (1) |
| methyldopa |
76.5 |
3 |
9284427 (1), 7735264 (1) |
Search CenterWatch for drugs/clinical trials and news about NISCH
|
Transcripts
for NISCH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NISCH gene (3 alternative transcripts): NM_001276293.1 NM_001276294.1 NM_007184.3 Unigene Cluster for NISCH: Nischarin Hs.435290 [show with all ESTs]Unigene Representative Sequence: NM_00718414 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479054(uc003deg.1) ENST00000488380(uc003dec.1) ENST00000420808
ENST00000489895 ENST00000488157 ENST00000490425 ENST00000464280 ENST00000481211
ENST00000474188 ENST00000485765 ENST00000460759 ENST00000488243 ENST00000467594
ENST00000345716(uc003ded.4 uc003dee.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NISCH (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NISCH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NISCH (NM_007184) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NISCH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NISCH |
Additional cDNA sequence: AB023192.1 AF058290.1 AF082516.1 AK027331.1 AK027428.1 AK075000.1 AK097732.1 AK291398.1 AK297657.1 AK302441.1 AK315001.1 AL117432.1 AL137405.1 BC038102.2 BC050552.1 BC054494.1 BC056900.1 24/31 DOTS entries (see all 31): DT.100665695 DT.40305252 DT.100665694 DT.91963176 DT.100863171 DT.211714 DT.100665696 DT.100665690 DT.120854842 DT.95200862 DT.100665693 DT.92444758 DT.100846780 DT.100665697 DT.120854855 DT.95373494 DT.95373496 DT.95373517 DT.102834400 DT.95194538 DT.95373499 DT.95373505 DT.100044307 DT.100665689 24/512 AceView cDNA sequences (see all 512): BQ057015 BQ894921 BQ276492 AB023192 BF869033 BM989943 AW073793 BF727193 AA351393 BG755139 F02144 CA841351 BQ058916 CK430251 AI801671 AW513092 T31924 AI888003 BE263686 BX431002 AA493834 CR623596 BQ962790 BG755662
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for NISCH (see all 18) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | · | 19c | · | 19d | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | · | 28c | · | 28d | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | |
| ExUns: | 28e | ^ | 29 |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | - | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for NISCH
|
Expression
for NISCH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NISCH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGGAGTGA
About this image
See NISCH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NISCH
SOURCE GeneReport for Unigene cluster: Hs.435290
UniProtKB/Swiss-Prot: NISCH_HUMAN, Q9Y2I1Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrinetissues
SABiosciences Custom PCR Arrays for NISCH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NISCH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NISCH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NISCH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NISCH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NISCH |
Orthologs
for NISCH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NISCH gene from 9/21 species (see all 21) About this table
ENSEMBL Gene Tree for NISCH (if available)
TreeFam Gene Tree for NISCH (if available) |
Paralogs
for NISCH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NISCH gene
- STK11IP2
NISCH for paralogs About GeneDecksing
|
Genomic Variants
for NISCH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NISCH (52489134 - 52527088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NISCH: --
Human Gene Mutation Database (HGMD): NISCH
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NISCH |
|
Disorders
/ Diseases
for NISCH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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NISCH for disorders About GeneDecksing
20/21  diseases for NISCH (see all 21): About MalaCardshigh blood pressure morphine dependence bipolar affective disorder congestive heart failure
sclerosing cholangitis essential hypertension diabetes mellitus rosacea
neurodegenerative disease brain disease hypertension ichthyosis
alzheimer's disease cholangitis pheochromocytoma blindness
breast cancer obesity cerebritis pancreatitis
2 diseases from the University of Copenhagen DISEASES database for NISCH:Morphine dependence Sclerosing cholangitis 10/18 Novoseek disease relationships for NISCH gene (see all 18) About this table
Human Genome Epidemiology (HuGE) Navigator: NISCH (4 documents)
Export disorders for NISCH gene to outside databases
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Publications
for NISCH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for NISCH gene, integrated from 9 sources (see all 188):
(articles sorted by number of sources associating them with NISCH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization. (PubMed id 10882231)1, 2, 3, 9 Piletz J.E....Reis D.J. (2000)
- Insulin receptor substrate 4 associates with the protein IRAS. (PubMed id 11912194)1, 2, 3 Sano H....Lienhard G.E. (2002)
- IRAS splice variants. (PubMed id 15028621)1, 2, 9 Piletz J.E....Ziegler D. (2003)
- Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region. (PubMed id 15475348)1, 2, 9 Lim K.-P. and Hong W. (2004)
- IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells. (PubMed id 12868002)1, 2, 9 Dontenwill M....Bousquet P. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- IRAS is an anti-apoptotic protein. (PubMed id 15028619)1, 2 Dontenwill M.... Bousquetd P. (2003)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera. (PubMed id 9851558)1, 2 Ivanov T.R.... Piletz J.E. (1998)
- Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein. (PubMed id 16598778)1, 9 Li F....Li J. (2006)
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External Searches for NISCH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NISCH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NISCH gene
(According to HUGE)
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Specialized Databases showing NISCH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for NISCH | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NISCH gene:
Search GeneIP for patents involving NISCH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NISCH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NISCH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NISCH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NISCH | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NISCH | | OriGene 3'-UTR Clone for NISCH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NISCH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NISCH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NISCH | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NISCH |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NISCH |
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