NIPSNAP3B Gene
protein-coding GIFtS: 47
GCID: GC09P107526
|
|
nipsnap homolog 3B (C. elegans)
| |
Aliases
for NIPSNAP3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nipsnap Homolog 3B (C. Elegans)1 2 | | NIPSNAP32 3 | | SNAP12 3 | | FLJ112751 | | Protein NipSnap Homolog 3B2 | | NipSnap3B3 |
Export aliases for NIPSNAP3B gene to outside databasesPrevious GC identifers: GC09P102906 GC09P104606 GC09P106566 GC09P077128 |
Summaries
for NIPSNAP3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NIPSNAP3B:
NIPSNAP3B belongs to a family of proteins with putative roles in vesicular trafficking (Buechler et al., 2004 (PubMed15177564)).(supplied by OMIM, Mar 2008)
|
Genomic Views
for NIPSNAP3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NIPSNAP3B gene promoter:
CHOP-10 PPAR-gamma1 Nkx6-1 COMP1 c-Myb PPAR-gamma2 TGIF POU3F2 C/EBPalpha Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NIPSNAP3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIPSNAP3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31.1 Ensembl cytogenetic band: 9q31.1 HGNC cytogenetic band: 9q31.3NIPSNAP3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P107526: view genomic region
(about GC identifiers)
Start:
|
107,526,438 bp from pter |
End:
|
107,539,738 bp from pter |
Size:
|
13,301 bases |
Orientation:
|
plus strand |
|
Proteins
for NIPSNAP3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPS3B_HUMAN, Q9BS92 (See
protein sequence)Recommended Name: Protein NipSnap homolog 3B Size: 247 amino acids; 28313 Da
Secondary accessions: Q5VX30 Q9NUM2Explore the universe of human proteins at neXtProt for NIPSNAP3B: NX_Q9BS92
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BS92
NIPSNAP3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060846.2
ENSEMBL proteins: ENSP00000435209 ENSP00000363894
Human Recombinant Protein Products:
NIPSNAP3B Antibody Products:
Assay Products for NIPSNAP3B: |
Protein
Domains /
Families
for NIPSNAP3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NIPSNAP3B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BS92ProtoNet protein and cluster: Q9BS92 1 Blocks protein family: IPB012577 NIPSNAP
UniProtKB/Swiss-Prot: NPS3B_HUMAN, Q9BS92Similarity: Belongs to the NipSnap family |
Function
for NIPSNAP3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIPSNAP3B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIPSNAP3B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NIPSNAP3B (NM_018376) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NIPSNAP3B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIPSNAP3B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPSNAP3B |
1 GenomeRNAi human phenotype for NIPSNAP3B:
Animal Models:
1 MGI phenotypic allele  for Nipsnap3b (no phenotypes)
NIPSNAP3B for phenotypes About GeneDecksing
|
Pathways & Interactions
for NIPSNAP3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NIPSNAP3B
|
Drugs & Compounds
for NIPSNAP3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NIPSNAP3B
Search CenterWatch for drugs/clinical trials and news about NIPSNAP3B / NPS3B
|
Transcripts
for NIPSNAP3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NIPSNAP3B gene: NM_018376.2 Unigene Cluster for NIPSNAP3B: Nipsnap homolog 3B (C. elegans) Hs.429294 [show with all ESTs]Unigene Representative Sequence: BX6476523 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000460936 ENST00000374762(uc004bci.3 uc004bcj.1) ENST00000461177
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIPSNAP3B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIPSNAP3B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NIPSNAP3B (NM_018376) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NIPSNAP3B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIPSNAP3B |
Additional cDNA sequence: AK002137.1 AK310397.1 BC005202.1 BC017914.1 BX647652.1 10 DOTS entries: DT.92445394 DT.40109354 DT.95347029 DT.40217360 DT.75116842 DT.95266317 DT.91701826 DT.92445391 DT.312757 DT.95309384 24/297 AceView cDNA sequences (see all 297): BQ952282 AA297133 AV728933 BX107655 AL117557 CR615189 T08781 AK091667 AI040606 CR622522 AL550077 AA629596 AW118801 AA602985 CR621160 CR609627 BF510739 BI758173 BI753199 AV709474 AI129675 C01738 CK820001 AW593019
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NIPSNAP3B About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NIPSNAP3B
|
Expression
for NIPSNAP3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NIPSNAP3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGGAACCT
About this image
See NIPSNAP3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NIPSNAP3B
SOURCE GeneReport for Unigene cluster: Hs.429294
SABiosciences Custom PCR Arrays for NIPSNAP3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIPSNAP3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NIPSNAP3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIPSNAP3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIPSNAP3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPSNAP3B |
Orthologs
for NIPSNAP3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NIPSNAP3B gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Nipsnap3b1 , 5 |
nipsnap homolog 3B (C. elegans)1, 5 |
81.51(n)1
78.14(a)1 |
|
4 (28.57 cM)5
665361 NM_025623.21 NP_079899.11
530118805 |
chicken
(Gallus gallus) |
Aves |
NIPSNAP3A6 |
Uncharacterized protein |
68(a) |
1 → many |
Z(53588282-53597925) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
62(a) |
1 → many |
2(75520098-75527638) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc564662 |
hypothetical protein MGC56466 |
70.97(n) |
|
393234 BC049027.1 |
ENSEMBL Gene Tree for NIPSNAP3B (if available)
TreeFam Gene Tree for NIPSNAP3B (if available) |
Paralogs
for NIPSNAP3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NIPSNAP3B gene
- NIPSNAP12 GBAS2 NIPSNAP3A2
1 SIMAP similar gene for NIPSNAP3B using alignment to 3 protein entries: NPS3B_HUMAN (see all proteins):NIPSNAP3A
NIPSNAP3B for paralogs About GeneDecksing
|
Genomic Variants
for NIPSNAP3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NIPSNAP3B (107526438 - 107539738 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NIPSNAP3B
2 CNVs: 96229 96228 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIPSNAP3B |
|
Disorders
/ Diseases
for NIPSNAP3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NIPSNAP3B for disorders About GeneDecksing
OMIM gene information: 608872
OMIM disorders: --
1  disease for NIPSNAP3B: About MalaCardstangier disease
Human Genome Epidemiology (HuGE) Navigator: NIPSNAP3B (2 documents)
Export disorders for NIPSNAP3B gene to outside databases
|
Publications
for NIPSNAP3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NIPSNAP3B gene integrated from 9 sources:
(articles sorted by number of sources associating them with NIPSNAP3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Human and mouse ABCA1 comparative sequencing and transgenesis studies revealing novel regulatory sequences. (PubMed id 11352567)1, 2 Qiu Y.... Cheng J.-F. (2001)
- Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1. (PubMed id 15177564)1, 9 Buechler C....Schmitz G. (2004)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. (PubMed id 19922823)9 Reppe S....Gautvik K.M. (2010)
|
External Searches for NIPSNAP3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NIPSNAP3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NIPSNAP3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NIPSNAP3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NIPSNAP3B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NIPSNAP3B gene:
Search GeneIP for patents involving NIPSNAP3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NIPSNAP3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NIPSNAP3B | | OriGene shRNA RFP for NIPSNAP3B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NIPSNAP3B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIPSNAP3B | | | OriGene Protein Over-expression Lysate for NIPSNAP3B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NIPSNAP3B | | OriGene 3'-UTR Clone for NIPSNAP3B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIPSNAP3B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIPSNAP3B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NIPSNAP3B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NIPSNAP3B | | OriGene Custom Protein Services for NIPSNAP3B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NIPSNAP3B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIPSNAP3B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIPSNAP3B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NIPSNAP3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIPSNAP3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIPSNAP3B |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | NIPSNAP3B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPSNAP3B |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIPSNAP3B |
|
|
|
|
