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Aliases for NIPSNAP3A Gene

Aliases for NIPSNAP3A Gene

  • Nipsnap Homolog 3A 2 3 5
  • Target For Salmonella Secreted Protein C 3 4
  • Protein NipSnap Homolog 4 3 4
  • NIPSNAP4 3 4
  • TASSC 3 4
  • Nipsnap Homolog 3A (C. Elegans) 2
  • Protein NipSnap Homolog 3A 3
  • NipSnap3A 4
  • HSPC299 3

External Ids for NIPSNAP3A Gene

Previous GeneCards Identifiers for NIPSNAP3A Gene

  • GC09P102889
  • GC09P104589
  • GC09P106549
  • GC09P107509
  • GC09P077113

Summaries for NIPSNAP3A Gene

Entrez Gene Summary for NIPSNAP3A Gene

  • NIPSNAP3A belongs to a family of proteins with putative roles in vesicular transport (Buechler et al., 2004 [PubMed 15177564]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NIPSNAP3A Gene

NIPSNAP3A (Nipsnap Homolog 3A) is a Protein Coding gene. An important paralog of this gene is NIPSNAP3B.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIPSNAP3A Gene

Genomics for NIPSNAP3A Gene

Regulatory Elements for NIPSNAP3A Gene

Enhancers for NIPSNAP3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G104745 1.4 FANTOM5 ENCODE 20.6 -0.4 -350 3.9 PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 NIPSNAP3A ABCA1 OR13D3P
GH09G104772 1.5 Ensembl ENCODE dbSUPER 14.5 +27.0 27000 4.0 HDGF PKNOX1 ATF1 ARNT WRNIP1 YY1 TCF12 ZNF766 ELK1 GATA2 NIPSNAP3A GC09P104774 GC09P104783
GH09G104763 1 ENCODE 20 +16.6 16567 2.0 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF766 GLIS2 ZNF202 SP3 NIPSNAP3A NIPSNAP3B GC09P104774
GH09G104783 0.6 dbSUPER 24.9 +35.8 35849 0.3 GATAD2A FOXA2 ESRRA FOXA3 THRB RARA FOXA1 GATA3 CEBPA RXRB NIPSNAP3A GC09P104783 GC09P104774
GH09G104743 0.9 Ensembl ENCODE 16.5 -4.0 -4038 0.3 CTCF ZNF654 ZSCAN4 TRIM22 REST RAD21 SMC3 ZNF143 NIPSNAP3A OR13D3P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NIPSNAP3A on UCSC Golden Path with GeneCards custom track

Promoters for NIPSNAP3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000238995 212 1801 PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2

Genomic Location for NIPSNAP3A Gene

Chromosome:
9
Start:
104,747,688 bp from pter
End:
104,760,122 bp from pter
Size:
12,435 bases
Orientation:
Plus strand

Genomic View for NIPSNAP3A Gene

Genes around NIPSNAP3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIPSNAP3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIPSNAP3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIPSNAP3A Gene

Proteins for NIPSNAP3A Gene

  • Protein details for NIPSNAP3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFN0-NPS3A_HUMAN
    Recommended name:
    Protein NipSnap homolog 3A
    Protein Accession:
    Q9UFN0
    Secondary Accessions:
    • A6NM55
    • Q5VX32
    • Q9BRV7
    • Q9H843
    • Q9P083

    Protein attributes for NIPSNAP3A Gene

    Size:
    247 amino acids
    Molecular mass:
    28467 Da
    Quaternary structure:
    • Interacts with the Salmonella typhimurium virulence protein spiC.
    SequenceCaution:
    • Sequence=AAF28977.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NIPSNAP3A Gene

Post-translational modifications for NIPSNAP3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NIPSNAP3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NIPSNAP3A Gene

Domains & Families for NIPSNAP3A Gene

Protein Domains for NIPSNAP3A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NIPSNAP3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UFN0

UniProtKB/Swiss-Prot:

NPS3A_HUMAN :
  • Belongs to the NipSnap family.
Family:
  • Belongs to the NipSnap family.
genes like me logo Genes that share domains with NIPSNAP3A: view

No data available for Gene Families for NIPSNAP3A Gene

Function for NIPSNAP3A Gene

Gene Ontology (GO) - Molecular Function for NIPSNAP3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with NIPSNAP3A: view

Phenotypes for NIPSNAP3A Gene

GenomeRNAi human phenotypes for NIPSNAP3A:
genes like me logo Genes that share phenotypes with NIPSNAP3A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NIPSNAP3A

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NIPSNAP3A Gene

Localization for NIPSNAP3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIPSNAP3A Gene

Cytoplasm, cytosol. Note=May be part of some vesicular structure distinct from lysosomal vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NIPSNAP3A gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for NIPSNAP3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with NIPSNAP3A: view

Pathways & Interactions for NIPSNAP3A Gene

SuperPathways for NIPSNAP3A Gene

No Data Available

Interacting Proteins for NIPSNAP3A Gene

Gene Ontology (GO) - Biological Process for NIPSNAP3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NIPSNAP3A Gene

Drugs & Compounds for NIPSNAP3A Gene

No Compound Related Data Available

Transcripts for NIPSNAP3A Gene

mRNA/cDNA for NIPSNAP3A Gene

Unigene Clusters for NIPSNAP3A Gene

Nipsnap homolog 3A (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIPSNAP3A Gene

No ASD Table

Relevant External Links for NIPSNAP3A Gene

GeneLoc Exon Structure for
NIPSNAP3A
ECgene alternative splicing isoforms for
NIPSNAP3A

Expression for NIPSNAP3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NIPSNAP3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NIPSNAP3A Gene

This gene is overexpressed in Fetal testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NIPSNAP3A Gene



Protein tissue co-expression partners for NIPSNAP3A Gene

NURSA nuclear receptor signaling pathways regulating expression of NIPSNAP3A Gene:

NIPSNAP3A

SOURCE GeneReport for Unigene cluster for NIPSNAP3A Gene:

Hs.530275

mRNA Expression by UniProt/SwissProt for NIPSNAP3A Gene:

Q9UFN0-NPS3A_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in liver, kidney and muscle. Expressed at intermediate level in brain, heart, colon, thymus, kidney, small intestine, placenta, lung, leukocytes and spleen.

Evidence on tissue expression from TISSUES for NIPSNAP3A Gene

  • Nervous system(4.8)
  • Blood(4.2)
  • Bone marrow(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with NIPSNAP3A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NIPSNAP3A Gene

Orthologs for NIPSNAP3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for NIPSNAP3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NIPSNAP3A 34 35
  • 99.87 (n)
cow
(Bos Taurus)
Mammalia NIPSNAP3A 34 35
  • 91.5 (n)
dog
(Canis familiaris)
Mammalia LOC474791 34
  • 90.96 (n)
NIPSNAP3A 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nipsnap3b 34 16
  • 83.94 (n)
Nipsnap3a 35
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nipsnap3b 34
  • 83.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves NIPSNAP3A 34
  • 72.98 (n)
-- 35
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nipsnap3a 34
  • 65.56 (n)
zebrafish
(Danio rerio)
Actinopterygii nipsnap3 34 35
  • 62.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8944 35
  • 36 (a)
OneToMany
Species where no ortholog for NIPSNAP3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NIPSNAP3A Gene

ENSEMBL:
Gene Tree for NIPSNAP3A (if available)
TreeFam:
Gene Tree for NIPSNAP3A (if available)

Paralogs for NIPSNAP3A Gene

Paralogs for NIPSNAP3A Gene

(1) SIMAP similar genes for NIPSNAP3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NIPSNAP3A: view

Variants for NIPSNAP3A Gene

Sequence variations from dbSNP and Humsavar for NIPSNAP3A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000038817 -- 104,756,151(+) TGGAG(A/G)AGAAA intron-variant
rs1000130806 -- 104,756,993(+) GAGAC(A/G)GGATT intron-variant
rs1000170407 -- 104,752,220(+) AACTT(-/AAA)TAGAA intron-variant
rs1000226865 -- 104,751,865(+) AGGAG(A/G)ATAAG intron-variant
rs1000638128 -- 104,754,947(+) TAAAC(C/T)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NIPSNAP3A Gene

Variant ID Type Subtype PubMed ID
esv3891705 CNV loss 25118596
esv3891706 CNV gain 25118596
nsv521783 CNV loss 19592680

Variation tolerance for NIPSNAP3A Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NIPSNAP3A Gene

Human Gene Mutation Database (HGMD)
NIPSNAP3A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NIPSNAP3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIPSNAP3A Gene

Disorders for NIPSNAP3A Gene

Relevant External Links for NIPSNAP3A

Genetic Association Database (GAD)
NIPSNAP3A
Human Genome Epidemiology (HuGE) Navigator
NIPSNAP3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NIPSNAP3A

No disorders were found for NIPSNAP3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIPSNAP3A Gene

Publications for NIPSNAP3A Gene

  1. Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1. (PMID: 15177564) Buechler C. … Schmitz G. (Genomics 2004) 2 3 22 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of a NIPSNAP homologue as host cell target for Salmonella virulence protein SpiC. (PMID: 12427096) Lee A.H. … Daefler S. (Cell. Microbiol. 2002) 3 4 64

Products for NIPSNAP3A Gene

Sources for NIPSNAP3A Gene

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