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Aliases for NIPSNAP3A Gene

Aliases for NIPSNAP3A Gene

  • Nipsnap Homolog 3A (C. Elegans) 2 3
  • TASSC 3 4 6
  • Target For Salmonella Secreted Protein C 3 4
  • Protein NipSnap Homolog 4 3 4
  • NIPSNAP4 3 4
  • Protein NipSnap Homolog 3A 3
  • NipSnap3A 4
  • HSPC299 3

External Ids for NIPSNAP3A Gene

Previous GeneCards Identifiers for NIPSNAP3A Gene

  • GC09P102889
  • GC09P104589
  • GC09P106549
  • GC09P107509
  • GC09P077113

Summaries for NIPSNAP3A Gene

Entrez Gene Summary for NIPSNAP3A Gene

  • NIPSNAP3A belongs to a family of proteins with putative roles in vesicular transport (Buechler et al., 2004 [PubMed 15177564]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NIPSNAP3A Gene

NIPSNAP3A (Nipsnap Homolog 3A (C. Elegans)) is a Protein Coding gene. An important paralog of this gene is NIPSNAP3B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIPSNAP3A Gene

Genomics for NIPSNAP3A Gene

Regulatory Elements for NIPSNAP3A Gene

Genomic Location for NIPSNAP3A Gene

Start:
104,747,688 bp from pter
End:
104,760,122 bp from pter
Size:
12,435 bases
Orientation:
Plus strand

Genomic View for NIPSNAP3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIPSNAP3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIPSNAP3A Gene

Proteins for NIPSNAP3A Gene

  • Protein details for NIPSNAP3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFN0-NPS3A_HUMAN
    Recommended name:
    Protein NipSnap homolog 3A
    Protein Accession:
    Q9UFN0
    Secondary Accessions:
    • A6NM55
    • Q5VX32
    • Q9BRV7
    • Q9H843
    • Q9P083

    Protein attributes for NIPSNAP3A Gene

    Size:
    247 amino acids
    Molecular mass:
    28467 Da
    Quaternary structure:
    • Interacts with the Salmonella typhimurium virulence protein spiC.
    SequenceCaution:
    • Sequence=AAF28977.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NIPSNAP3A Gene

Proteomics data for NIPSNAP3A Gene at MOPED

Post-translational modifications for NIPSNAP3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NIPSNAP3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NIPSNAP3A Gene

Domains for NIPSNAP3A Gene

Protein Domains for NIPSNAP3A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NIPSNAP3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UFN0

UniProtKB/Swiss-Prot:

NPS3A_HUMAN :
  • Q9UFN0
Family:
  • Belongs to the NipSnap family.
genes like me logo Genes that share domains with NIPSNAP3A: view

No data available for Gene Families for NIPSNAP3A Gene

Function for NIPSNAP3A Gene

Gene Ontology (GO) - Molecular Function for NIPSNAP3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with NIPSNAP3A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NIPSNAP3A Gene

Localization for NIPSNAP3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIPSNAP3A Gene

Cytoplasm, cytosol. Note=May be part of some vesicular structure distinct from lysosomal vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIPSNAP3A Gene COMPARTMENTS Subcellular localization image for NIPSNAP3A gene
Compartment Confidence
cytosol 5
mitochondrion 3
vacuole 1

Gene Ontology (GO) - Cellular Components for NIPSNAP3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with NIPSNAP3A: view

Pathways for NIPSNAP3A Gene

SuperPathways for NIPSNAP3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIPSNAP3A Gene

None

No data available for Pathways by source for NIPSNAP3A Gene

Transcripts for NIPSNAP3A Gene

mRNA/cDNA for NIPSNAP3A Gene

Unigene Clusters for NIPSNAP3A Gene

Nipsnap homolog 3A (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NIPSNAP3A Gene

No ASD Table

Relevant External Links for NIPSNAP3A Gene

GeneLoc Exon Structure for
NIPSNAP3A
ECgene alternative splicing isoforms for
NIPSNAP3A

Expression for NIPSNAP3A Gene

mRNA expression in normal human tissues for NIPSNAP3A Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NIPSNAP3A Gene

SOURCE GeneReport for Unigene cluster for NIPSNAP3A Gene Hs.530275

mRNA Expression by UniProt/SwissProt for NIPSNAP3A Gene

Q9UFN0-NPS3A_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in liver, kidney and muscle. Expressed at intermediate level in brain, heart, colon, thymus, kidney, small intestine, placenta, lung, leukocytes and spleen.
genes like me logo Genes that share expressions with NIPSNAP3A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NIPSNAP3A Gene

Orthologs for NIPSNAP3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for NIPSNAP3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NIPSNAP3A 35
  • 99.87 (n)
  • 100 (a)
NIPSNAP3A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NIPSNAP3A 35
  • 91.5 (n)
  • 89.88 (a)
NIPSNAP3A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC474791 35
  • 90.96 (n)
  • 90.28 (a)
NIPSNAP3A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nipsnap3a 16
Nipsnap3a 36
  • 76 (a)
OneToMany
Nipsnap3b 35
  • 83.94 (n)
  • 83.4 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nipsnap3b 35
  • 83.54 (n)
  • 82.19 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 66 (a)
OneToMany
NIPSNAP3A 35
  • 72.98 (n)
  • 70.93 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nipsnap3a 35
  • 65.56 (n)
  • 62.5 (a)
zebrafish
(Danio rerio)
Actinopterygii nipsnap3 35
  • 62.16 (n)
  • 61.26 (a)
nipsnap3 36
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8944 36
  • 36 (a)
OneToMany
Species with no ortholog for NIPSNAP3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NIPSNAP3A Gene

ENSEMBL:
Gene Tree for NIPSNAP3A (if available)
TreeFam:
Gene Tree for NIPSNAP3A (if available)

Paralogs for NIPSNAP3A Gene

Paralogs for NIPSNAP3A Gene

Selected SIMAP similar genes for NIPSNAP3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NIPSNAP3A: view

Variants for NIPSNAP3A Gene

Sequence variations from dbSNP and Humsavar for NIPSNAP3A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1046115 -- 104,759,442(+) AGGTG(G/T)TAAGT utr-variant-3-prime
rs1061582 -- 104,748,932(+) TAAAA(A/G)TCATC intron-variant
rs1858555 -- 104,750,150(+) CGTGC(A/G)TAGTT intron-variant
rs2274870 - 104,752,933(+) AGTTC(A/G)GAAAG missense, reference
rs2297397 -- 104,759,215(+) AATGT(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NIPSNAP3A Gene

Variant ID Type Subtype PubMed ID
nsv893672 CNV Gain+Loss 21882294
nsv521783 CNV Loss 19592680

Relevant External Links for NIPSNAP3A Gene

HapMap Linkage Disequilibrium report
NIPSNAP3A
Human Gene Mutation Database (HGMD)
NIPSNAP3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIPSNAP3A Gene

Disorders for NIPSNAP3A Gene

(1) University of Copenhagen DISEASES for NIPSNAP3A Gene

Relevant External Links for NIPSNAP3A

Genetic Association Database (GAD)
NIPSNAP3A
Human Genome Epidemiology (HuGE) Navigator
NIPSNAP3A
genes like me logo Genes that share disorders with NIPSNAP3A: view

No data available for UniProtKB/Swiss-Prot for NIPSNAP3A Gene

Publications for NIPSNAP3A Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1. (PMID: 15177564) Buechler C. … Schmitz G. (Genomics 2004) 3 23
  3. Identification of a NIPSNAP homologue as host cell target for Salmonella virulence protein SpiC. (PMID: 12427096) Lee A.H. … Daefler S. (Cell. Microbiol. 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for NIPSNAP3A Gene

Sources for NIPSNAP3A Gene

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