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Aliases for NIPSNAP3A Gene

Aliases for NIPSNAP3A Gene

  • Nipsnap Homolog 3A 2 3
  • Target For Salmonella Secreted Protein C 3 4
  • Nipsnap Homolog 3A (C. Elegans) 2 5
  • Protein NipSnap Homolog 4 3 4
  • NIPSNAP4 3 4
  • TASSC 3 4
  • NipSnap3A 4
  • HSPC299 3

External Ids for NIPSNAP3A Gene

Previous GeneCards Identifiers for NIPSNAP3A Gene

  • GC09P102889
  • GC09P104589
  • GC09P106549
  • GC09P107509
  • GC09P077113

Summaries for NIPSNAP3A Gene

Entrez Gene Summary for NIPSNAP3A Gene

  • NIPSNAP3A belongs to a family of proteins with putative roles in vesicular transport (Buechler et al., 2004 [PubMed 15177564]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NIPSNAP3A Gene

NIPSNAP3A (Nipsnap Homolog 3A) is a Protein Coding gene. An important paralog of this gene is NIPSNAP3B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIPSNAP3A Gene

Genomics for NIPSNAP3A Gene

Regulatory Elements for NIPSNAP3A Gene

Enhancers for NIPSNAP3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NIPSNAP3A on UCSC Golden Path with GeneCards custom track

Promoters for NIPSNAP3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NIPSNAP3A on UCSC Golden Path with GeneCards custom track

Genomic Location for NIPSNAP3A Gene

Chromosome:
9
Start:
104,747,688 bp from pter
End:
104,760,122 bp from pter
Size:
12,435 bases
Orientation:
Plus strand

Genomic View for NIPSNAP3A Gene

Genes around NIPSNAP3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIPSNAP3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIPSNAP3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIPSNAP3A Gene

Proteins for NIPSNAP3A Gene

  • Protein details for NIPSNAP3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFN0-NPS3A_HUMAN
    Recommended name:
    Protein NipSnap homolog 3A
    Protein Accession:
    Q9UFN0
    Secondary Accessions:
    • A6NM55
    • Q5VX32
    • Q9BRV7
    • Q9H843
    • Q9P083

    Protein attributes for NIPSNAP3A Gene

    Size:
    247 amino acids
    Molecular mass:
    28467 Da
    Quaternary structure:
    • Interacts with the Salmonella typhimurium virulence protein spiC.
    SequenceCaution:
    • Sequence=AAF28977.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NIPSNAP3A Gene

Proteomics data for NIPSNAP3A Gene at MOPED

Post-translational modifications for NIPSNAP3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NIPSNAP3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NIPSNAP3A Gene

Domains & Families for NIPSNAP3A Gene

Protein Domains for NIPSNAP3A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NIPSNAP3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UFN0

UniProtKB/Swiss-Prot:

NPS3A_HUMAN :
  • Belongs to the NipSnap family.
Family:
  • Belongs to the NipSnap family.
genes like me logo Genes that share domains with NIPSNAP3A: view

No data available for Gene Families for NIPSNAP3A Gene

Function for NIPSNAP3A Gene

Phenotypes for NIPSNAP3A Gene

GenomeRNAi human phenotypes for NIPSNAP3A:
genes like me logo Genes that share phenotypes with NIPSNAP3A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NIPSNAP3A

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NIPSNAP3A Gene

Localization for NIPSNAP3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIPSNAP3A Gene

Cytoplasm, cytosol. Note=May be part of some vesicular structure distinct from lysosomal vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIPSNAP3A Gene COMPARTMENTS Subcellular localization image for NIPSNAP3A gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 3
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NIPSNAP3A Gene

Pathways & Interactions for NIPSNAP3A Gene

SuperPathways for NIPSNAP3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIPSNAP3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NIPSNAP3A Gene

Drugs & Compounds for NIPSNAP3A Gene

No Compound Related Data Available

Transcripts for NIPSNAP3A Gene

mRNA/cDNA for NIPSNAP3A Gene

Unigene Clusters for NIPSNAP3A Gene

Nipsnap homolog 3A (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NIPSNAP3A Gene

No ASD Table

Relevant External Links for NIPSNAP3A Gene

GeneLoc Exon Structure for
NIPSNAP3A
ECgene alternative splicing isoforms for
NIPSNAP3A

Expression for NIPSNAP3A Gene

mRNA expression in normal human tissues for NIPSNAP3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NIPSNAP3A Gene

This gene is overexpressed in Fetal testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NIPSNAP3A Gene



SOURCE GeneReport for Unigene cluster for NIPSNAP3A Gene Hs.530275

mRNA Expression by UniProt/SwissProt for NIPSNAP3A Gene

Q9UFN0-NPS3A_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in liver, kidney and muscle. Expressed at intermediate level in brain, heart, colon, thymus, kidney, small intestine, placenta, lung, leukocytes and spleen.
genes like me logo Genes that share expression patterns with NIPSNAP3A: view

Protein tissue co-expression partners for NIPSNAP3A Gene

Primer Products

No data available for mRNA differential expression in normal tissues for NIPSNAP3A Gene

Orthologs for NIPSNAP3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for NIPSNAP3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NIPSNAP3A 35
  • 91.5 (n)
  • 89.88 (a)
NIPSNAP3A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC474791 35
  • 90.96 (n)
  • 90.28 (a)
NIPSNAP3A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nipsnap3b 35
  • 83.94 (n)
  • 83.4 (a)
Nipsnap3b 16
Nipsnap3a 36
  • 76 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia NIPSNAP3A 35
  • 99.87 (n)
  • 100 (a)
NIPSNAP3A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nipsnap3b 35
  • 83.54 (n)
  • 82.19 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves NIPSNAP3A 35
  • 72.98 (n)
  • 70.93 (a)
-- 36
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nipsnap3a 35
  • 65.56 (n)
  • 62.5 (a)
zebrafish
(Danio rerio)
Actinopterygii nipsnap3 35
  • 62.16 (n)
  • 61.26 (a)
nipsnap3 36
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8944 36
  • 36 (a)
OneToMany
Species with no ortholog for NIPSNAP3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NIPSNAP3A Gene

ENSEMBL:
Gene Tree for NIPSNAP3A (if available)
TreeFam:
Gene Tree for NIPSNAP3A (if available)

Paralogs for NIPSNAP3A Gene

Paralogs for NIPSNAP3A Gene

(1) SIMAP similar genes for NIPSNAP3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NIPSNAP3A: view

Variants for NIPSNAP3A Gene

Sequence variations from dbSNP and Humsavar for NIPSNAP3A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2274870 - 104,752,933(+) AGTTC(A/G)GAAAG reference, missense
rs1046115 -- 104,759,442(+) AGGTG(G/T)TAAGT utr-variant-3-prime
rs1061582 -- 104,748,932(+) TAAAA(A/G)TCATC intron-variant
rs7853255 -- 104,757,046(+) CGCCT(C/T)GGCCT intron-variant
rs1858555 -- 104,750,150(+) CGTGC(A/G)TAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NIPSNAP3A Gene

Variant ID Type Subtype PubMed ID
nsv893672 CNV Gain+Loss 21882294
nsv521783 CNV Loss 19592680

Variation tolerance for NIPSNAP3A Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NIPSNAP3A Gene

Human Gene Mutation Database (HGMD)
NIPSNAP3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIPSNAP3A Gene

Disorders for NIPSNAP3A Gene

Relevant External Links for NIPSNAP3A

Genetic Association Database (GAD)
NIPSNAP3A
Human Genome Epidemiology (HuGE) Navigator
NIPSNAP3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NIPSNAP3A

No disorders were found for NIPSNAP3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIPSNAP3A Gene

Publications for NIPSNAP3A Gene

  1. Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1. (PMID: 15177564) Buechler C. … Schmitz G. (Genomics 2004) 2 3 23 67
  2. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for NIPSNAP3A Gene

Sources for NIPSNAP3A Gene

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