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Aliases for NIPSNAP1 Gene

Aliases for NIPSNAP1 Gene

  • Nipsnap Homolog 1 (C. Elegans) 2 3
  • 4-Nitrophenylphosphatase Domain And Non-Neuronal SNAP25-Like 1 2
  • NIPSNAP, C. Elegans, Homolog 1 2
  • NipSnap1 4

External Ids for NIPSNAP1 Gene

Previous GeneCards Identifiers for NIPSNAP1 Gene

  • GC22M026646
  • GC22M028275
  • GC22M029952
  • GC22M012914

Summaries for NIPSNAP1 Gene

Entrez Gene Summary for NIPSNAP1 Gene

  • This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for NIPSNAP1 Gene

NIPSNAP1 (Nipsnap Homolog 1 (C. Elegans)) is a Protein Coding gene. Diseases associated with NIPSNAP1 include phenylketonuria. GO annotations related to this gene include neurotransmitter binding. An important paralog of this gene is GBAS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIPSNAP1 Gene

Genomics for NIPSNAP1 Gene

Regulatory Elements for NIPSNAP1 Gene

Transcription factor binding sites by QIAGEN in the NIPSNAP1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NIPSNAP1 Gene

29,554,808 bp from pter
29,581,337 bp from pter
26,530 bases
Minus strand

Genomic View for NIPSNAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIPSNAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIPSNAP1 Gene

Proteins for NIPSNAP1 Gene

  • Protein details for NIPSNAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NipSnap homolog 1
    Protein Accession:
    Secondary Accessions:
    • B2RAY3
    • O43800

    Protein attributes for NIPSNAP1 Gene

    284 amino acids
    Molecular mass:
    33310 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NIPSNAP1 Gene

Proteomics data for NIPSNAP1 Gene at MOPED

Post-translational modifications for NIPSNAP1 Gene

  • Ubiquitination at Lys51, Lys65, Lys66, Lys193, and Lys253
  • Modification sites at PhosphoSitePlus

Other Protein References for NIPSNAP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NIPSNAP1 (NIPSNAP1)

No data available for DME Specific Peptides for NIPSNAP1 Gene

Domains for NIPSNAP1 Gene

Protein Domains for NIPSNAP1 Gene


Suggested Antigen Peptide Sequences for NIPSNAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NipSnap family.
  • Belongs to the NipSnap family.
genes like me logo Genes that share domains with NIPSNAP1: view

No data available for Gene Families for NIPSNAP1 Gene

Function for NIPSNAP1 Gene

Molecular function for NIPSNAP1 Gene

GENATLAS Biochemistry:
putative peroxisomal protein,involved in vesicular transport,member 1 of a new gene-family,homolog to a hypothetical protein (P34492) from C elegans

Gene Ontology (GO) - Molecular Function for NIPSNAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042165 neurotransmitter binding IEA --
genes like me logo Genes that share ontologies with NIPSNAP1: view
genes like me logo Genes that share phenotypes with NIPSNAP1: view

Animal Models for NIPSNAP1 Gene

MGI Knock Outs for NIPSNAP1:

Animal Model Products

CRISPR Products

miRNA for NIPSNAP1 Gene

miRTarBase miRNAs that target NIPSNAP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NIPSNAP1 Gene

Localization for NIPSNAP1 Gene

Subcellular locations from

Jensen Localization Image for NIPSNAP1 Gene COMPARTMENTS Subcellular localization image for NIPSNAP1 gene
Compartment Confidence
mitochondrion 4

Gene Ontology (GO) - Cellular Components for NIPSNAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane --
GO:0097060 synaptic membrane IEA --
genes like me logo Genes that share ontologies with NIPSNAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NIPSNAP1 Gene

Pathways for NIPSNAP1 Gene

SuperPathways for NIPSNAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIPSNAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019233 sensory perception of pain IEA --
genes like me logo Genes that share ontologies with NIPSNAP1: view

No data available for Pathways by source for NIPSNAP1 Gene

Transcripts for NIPSNAP1 Gene

Unigene Clusters for NIPSNAP1 Gene

Nipsnap homolog 1 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIPSNAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIPSNAP1 Gene

No ASD Table

Relevant External Links for NIPSNAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NIPSNAP1 Gene

mRNA expression in normal human tissues for NIPSNAP1 Gene

mRNA differential expression in normal tissues according to GTEx for NIPSNAP1 Gene

This gene is overexpressed in Liver (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NIPSNAP1 Gene

SOURCE GeneReport for Unigene cluster for NIPSNAP1 Gene Hs.173878

mRNA Expression by UniProt/SwissProt for NIPSNAP1 Gene

Tissue specificity: Ubiquitous. Highest expression in liver
genes like me logo Genes that share expressions with NIPSNAP1: view

Expression partners for NIPSNAP1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for NIPSNAP1 Gene

Orthologs for NIPSNAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NIPSNAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NIPSNAP1 35
  • 92.49 (n)
  • 95.77 (a)
  • 95 (a)
(Canis familiaris)
Mammalia NIPSNAP1 35
  • 92.67 (n)
  • 96.81 (a)
  • 94 (a)
(Mus musculus)
Mammalia Nipsnap1 35
  • 87.56 (n)
  • 94.37 (a)
Nipsnap1 16
Nipsnap1 36
  • 94 (a)
(Pan troglodytes)
Mammalia NIPSNAP1 35
  • 99.53 (n)
  • 99.3 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Nipsnap1 35
  • 88.5 (n)
  • 94.01 (a)
(Monodelphis domestica)
Mammalia mdo-mir-1546 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia NIPSNAP1 36
  • 81 (a)
(Gallus gallus)
Aves NIPSNAP1 35
  • 82.31 (n)
  • 88.45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nipsnap1 35
  • 72.52 (n)
  • 82.08 (a)
Str.15493 35
(Danio rerio)
Actinopterygii nipsnap1 35
  • 72.27 (n)
  • 76 (a)
nipsnap2 35
nipsnap1 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9741 35
fruit fly
(Drosophila melanogaster)
Insecta Nipsnap 37
  • 48 (a)
Nipsnap 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea K02D10.1a 37
  • 38 (a)
K02D10.1b 37
  • 36 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08092 35
  • 48.27 (n)
  • 39.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6771 36
  • 56 (a)
Species with no ortholog for NIPSNAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIPSNAP1 Gene

Gene Tree for NIPSNAP1 (if available)
Gene Tree for NIPSNAP1 (if available)

Paralogs for NIPSNAP1 Gene

Paralogs for NIPSNAP1 Gene

(1) SIMAP similar genes for NIPSNAP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NIPSNAP1: view

Variants for NIPSNAP1 Gene

Sequence variations from dbSNP and Humsavar for NIPSNAP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs6361 -- 29,561,332(+) CATTC(A/G)CAGGC intron-variant
rs370331 -- 29,562,874(+) gaagg(A/T)ggatc intron-variant
rs425992 -- 29,577,819(+) CCTCC(A/G)GCTCC intron-variant
rs433194 -- 29,579,116(+) caccc(A/G)ggttg intron-variant
rs456285 -- 29,570,094(+) TGTTC(C/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NIPSNAP1 Gene

Variant ID Type Subtype PubMed ID
nsv834172 CNV Loss 17160897
esv2665021 CNV Deletion 23128226
nsv521852 CNV Loss 19592680

Relevant External Links for NIPSNAP1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIPSNAP1 Gene

Disorders for NIPSNAP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NIPSNAP1 Gene in MalaCards »

(1) Disease for NIPSNAP1 Gene

(1) University of Copenhagen DISEASES for NIPSNAP1 Gene

Relevant External Links for NIPSNAP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NIPSNAP1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for NIPSNAP1 Gene

Publications for NIPSNAP1 Gene

  1. Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family. (PMID: 9661659) Seroussi E. … Dumanski J.P. (Gene 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for NIPSNAP1 Gene

Sources for NIPSNAP1 Gene

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