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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NIPAL4 Gene

protein-coding GIFtS: 48
GCID: GC05P156887

NIPA-like domain containing 4

(Previous name: NIPA-like 4 )

Explore 14 diseases affiliated with
NIPAL4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NIPA-Like Domain Containing 4¹ ²		ICHTHYIN²
ICHYN¹ ² ⁵		Magnesium Transporter NIPA4²
Non-Imprinted In Prader-Willi/Angelman Syndrome Region Protein 4² ³		ICHN³
NIPA-Like Protein 4² ³		Ichthyin³
NIPA-Like 4¹		NIPA4³
ARCI6²

External Ids:	HGNC: 28018¹	Entrez Gene: 348938²	Ensembl: ENSG00000172548⁷	OMIM: 609383⁵	UniProtKB: Q0D2K0³

Export aliases for NIPAL4 gene to outside databases

Previous GC identifers: GC05P156821 GC05P151975

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NIPAL4:

This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive

congenital ichthyosis. (provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: NIPA4_HUMAN, Q0D2K0

Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and

Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3)

from the hepoxilin pathway

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NIPAL4 gene promoter:
AhR ER-alpha AML1a MAZR AP-1 IRF-7A LUN-1 E47 Arnt
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for NIPAL4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIPAL4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q33.3

NIPAL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NIPAL4 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P156887: view genomic region (about GC identifiers)

Start:	156,887,027 bp from pter	End:	156,901,730 bp from pter
Size:	14,704 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NIPA4_HUMAN, Q0D2K0 (See protein sequence)

Recommended Name: Magnesium transporter NIPA4

Size: 466 amino acids; 50058 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=ABW69630.1; Type=Miscellaneous discrepancy; Note=Protein truncation is due to an exon 5

splice site mutation which is found in a ARCII patient;

Secondary accessions: A8S6F1 A8S6F5 A8S6F8 B4DLF3 Q0D2J8 Q0D2J9

Alternative splicing: 2 isoforms: Q0D2K0-1 Q0D2K0-2

Explore the universe of human proteins at neXtProt for NIPAL4: NX_Q0D2K0

NIPAL4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001092757.1 NP_001165763.1

ENSEMBL proteins:

ENSP00000406456 ENSP00000311687 ENSP00000430810

Human Recombinant Protein Products:

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	Uscn Proteins for NIPAL4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

NIPAL4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NIPAL4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NIPAL4 for domains About GeneDecksing

1 InterPro domain/family:

IPR008521 Mg_trans_NIPA

Graphical View of Domain Structure for InterPro Entry Q0D2K0

ProtoNet protein and cluster: Q0D2K0

UniProtKB/Swiss-Prot: NIPA4_HUMAN, Q0D2K0

Similarity: Belongs to the NIPA family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NIPA4_HUMAN, Q0D2K0

Function: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and

Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3)

from the hepoxilin pathway

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NIPAL4
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate NIPAL4 (see all 38):
		hsa-let-7d hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-let-7g hsa-let-7a hsa-miR-181b hsa-miR-4324

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPAL4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0015095	magnesium ion transmembrane transporter activity	IEA	--

NIPAL4 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for NIPAL4:

Cell cycle / mitosis defect

Decreased viability of wild-ty

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NIPAL4

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015693	magnesium ion transport	--	--

NIPAL4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NIPAL4
Search CenterWatch for drugs/clinical trials and news about NIPAL4 / NIPA4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NIPAL4 gene (2 alternative transcripts):

NM_001099287.1 NM_001172292.1

Unigene Cluster for NIPAL4:

NIPA-like domain containing 4

Hs.4285 [show with all ESTs]

Unigene Representative Sequence: NM_001099287

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000435489 ENST00000311946(uc003lwx.4 uc011ddq.2) ENST00000521390

ENST00000519150 ENST00000519946(uc010jin.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NIPAL4
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate NIPAL4 (see all 38):
		hsa-let-7d hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-let-7g hsa-let-7a hsa-miR-181b hsa-miR-4324

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NIPAL4

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Additional cDNA sequence:

AF131815.1 AK026158.1 AK296972.1 AK308830.1 AK309242.1 BC105708.1 BC105709.1 BC105710.1

2 DOTS entries:

DT.412443 DT.120837293

24/32 AceView cDNA sequences (see all 32):

AA053788 BG287705 BX116027 BM805696 BE564562 AF131815 BG698778 AA456520

CD559194 BG289364 AK026158 BG290248 AI377064 BG260369 AA035736 AA232126

BG260294 T80356 T10268 BG291891 AI141245 AW138350 AI453516 R53655

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NIPAL4 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8
SP1:			-						-
SP2:									-
SP3:			-

ECgene alternative splicing isoforms for NIPAL4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NIPAL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTGACTGT

About this image

NIPAL4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Glomerulus

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

See NIPAL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NIPAL4

SOURCE GeneReport for Unigene cluster: Hs.4285

UniProtKB/Swiss-Prot: NIPA4_HUMAN, Q0D2K0

Tissue specificity: Highly expressed in brain, lung, stomach, keratinocytes and leukocytes, and in all other tissues

tested except liver, thyroid and fetal brain

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPAL4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIPAL4 gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nipal4^{1 , 5}	NIPA-like domain containing 4^{1, 5}	83.83(n)¹ 84.9(a)¹		11 (27.59 cM)⁵ 214112¹ NM_172524.3¹ NP_766112.1¹ 46148155⁵
chicken (Gallus gallus)	Aves	NIPAL4¹	NIPA-like domain containing 4	68.94(n) 66.49(a)		416245 XM_414566.2 XP_414566.2
lizard (Anolis carolinensis)	Reptilia	NIPAL4⁶	--	60(a)	1 ↔ 1	GL343205.1(2728246-2733784)
zebrafish (Danio rerio)	Actinopterygii	zgc:91960¹	zgc:91960	58.97(n) 57.36(a)		436937 NM_001002664.1 NP_001002664.1
fruit fly (Drosophila melanogaster)	Insecta	spict⁶	spichthyin	41(a)	1 → many	2L(12704725-12706683)
worm (Caenorhabditis elegans)	Secernentea	nipa-1⁶	--	41(a)	1 → many	III(3112795-3127109)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G23870⁶ AT4G13800⁶ (see all 7)	uncharacterized protein (see all 7)	42(a) 40(a) (see all 7)	many ↔ many many ↔ many (see all 7)	3(8619192-8621907) 4(8001862-8004139)
rice (Oryza sativa)	Liliopsida	Os05g0513400¹	hypothetical protein	54.75(n) 46.39(a)		4339301 NM_001062562.1 NP_001056027.1

ENSEMBL Gene Tree for NIPAL4 (if available)
TreeFam Gene Tree for NIPAL4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NIPAL4 gene

NIPA1² NIPAL3² NIPAL1² NIPAL2² NIPA2²

4 SIMAP similar genes for NIPAL4 using alignment to 2 protein entries: NIPA4_HUMAN (see all proteins):

NIPA2 NIPAL1 NIPA1 NIPAL2

NIPAL4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199422217^1,2	C,	pathogenic	188940616(+)	`GGCTGC/ATGGAG`	4	/D /A	mis¹		1		EU	347
rs199422216^1,2	C	pathogenic	188946042(+)	`TCTTGC/TGACTC`	4	R *	stg¹		0	--	--	--	--
rs10051862^1,2	C,F,	--	151973964(+)	`AGCTCG/AGTTTA`	2	--	us2k¹ tfbs³		1		WA	118
rs78565801^1,2	C,F,	--	151974629(+)	`CATACC/GTATTT`	2	--	us2k¹		3		NA	124
rs79951742^1,2	C,	--	151975008(+)	`AAGGAA/GAGGAG`	2	--	us2k¹		2		NA	122
rs76319946^1,2	C,	--	151975114(+)	`GGCGAG/CAAGGA`	2	--	us2k¹		3		NA EA	242
rs80136550^1,2	C,F,	--	151975188(+)	`ACTTCC/TACCTC`	2	--	us2k¹		1		NA	120
rs12332192^1,2		--	151975756(+)	`GGGGGG/CCCAAA`	2	--	int¹		3		CSA WA	120
rs77243217^1,2	F,	--	151975768(+)	`CTGGGG/AAGGGG`	2	--	int¹		1		NA	120
rs10050868^1,2	C,F,	--	151975948(+)	`CACCCT/CGAGAG`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for NIPAL4 (156887027 - 156901730 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NIPAL4: --
Human Gene Mutation Database (HGMD): NIPAL4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIPAL4

DNA2.0 Custom Variant and Variant Library Synthesis for NIPAL4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NIPAL4 for disorders           About GeneDecksing

OMIM gene information: 609383
OMIM disorders: 612281
UniProtKB/Swiss-Prot: NIPA4_HUMAN, Q0D2K0

Defects in NIPAL4 are the cause of ichthyosis congenital autosomal recessive ichthyin-related (ARCII)

[MIM:612281]. ARCII is a disorder of keratinization with abnormal differentiation and desquamation of the epidermis.

The phenotype usually presents as non-bullous congenital ichthyosiform erythroderma (NCIE) with fine whitish scaling

on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Some of the

families may show a more lamellar phenotype (lamellar ichthyosis)

14 diseases for NIPAL4: About MalaCards

autosomal recessive congenital ichthyosis ichthyosis angelman syndrome congenital ichthyosiform erythroderma

spastic paraplegia hereditary spastic paraplegia palmoplantar keratosis ichthyosis vulgaris

paraplegia spasticity keratosis meningioma

thyroiditis leukemia

1 disease from the University of Copenhagen DISEASES database for NIPAL4:

Congenital ichthyosiform erythroderma

GeneTests: NIPAL4

Autosomal Recessive Congenital Ichthyosis

Human Genome Epidemiology (HuGE) Navigator: NIPAL4 (4 documents)

Export disorders for NIPAL4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NIPAL4 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with NIPAL4)

Utopia: connect your pdf to the dynamic
world of online information

Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis. (PubMed id 15317751)^{1, 2, 3, 9} Lefevre C.... Fischer J. (2004)
Congenital ichthyosis: mutations in ichthyin are associated with specific structural abnormalities in the granular layer of epidermis. (PubMed id 17557927)^{1, 2, 9} Dahlqvist J....Dahl N. (2007)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)^{1, 3} Yu W.... Gibbs R.A. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)^{1, 3} Andersson B.... Gibbs R.A. (1996)
NIPAL4/ichthyin is expressed in the granular layer of human epidermis and mutated in two Pakistani families with autosomal recessive ichthyosis. (PubMed id 20016120)^{1, 9} Wajid M....Christiano A.M. (2010)
Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole. (PubMed id 19197536)^{1, 9} Pavez LoriA" E....Vahlquist A. (2009)
The expression of epidermal lipoxygenases and transglu taminase-1 is perturbed by NIPAL4 mutations: indications of a common metabolic p athway essential for skin barrier homeostasis. (PubMed id 22622417)¹ Li H....Torma H. (2012)
Manifestation of diffuse yellowish keratoderma on the palms and soles in autosomal recessive congenital ichthyosis patients may be ind icative of mutations in NIPAL4. (PubMed id 22098531)¹ Alavi A....Elahi E. (2012)
Ichthyin/NIPAL4 localizes to keratins and desmosomes i n epidermis and Ichthyin mutations affect epidermal lipid metabolism. (PubMed id 22258272)¹ Dahlqvist J....Dahl N. (2012)
Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)¹ Han S....Kang D. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 348938	HGNC: 28018	AceView: LOC348938	Ensembl:ENSG00000172548	euGenes: HUgn348938
ECgene: NIPAL4	H-InvDB: NIPAL4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NIPAL4	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ICHTHYIN

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NIPA-like domain containing 4

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