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Aliases for NIPAL3 Gene

Aliases for NIPAL3 Gene

  • NIPA-Like Domain Containing 3 2 3
  • NPAL3 3 4
  • NIPA-Like Protein 3 3
  • DJ462O23.2 3

External Ids for NIPAL3 Gene

Previous HGNC Symbols for NIPAL3 Gene

  • NPAL3

Previous GeneCards Identifiers for NIPAL3 Gene

  • GC01P024616
  • GC01P024742
  • GC01P022994

Summaries for NIPAL3 Gene

GeneCards Summary for NIPAL3 Gene

NIPAL3 (NIPA-Like Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include magnesium ion transmembrane transporter activity. An important paralog of this gene is NIPA2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIPAL3 Gene

Genomics for NIPAL3 Gene

Regulatory Elements for NIPAL3 Gene

Genomic Location for NIPAL3 Gene

Start:
24,415,750 bp from pter
End:
24,472,983 bp from pter
Size:
57,234 bases
Orientation:
Plus strand

Genomic View for NIPAL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIPAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIPAL3 Gene

Proteins for NIPAL3 Gene

  • Protein details for NIPAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P499-NPAL3_HUMAN
    Recommended name:
    NIPA-like protein 3
    Protein Accession:
    Q6P499
    Secondary Accessions:
    • A2A298
    • Q6MZT9
    • Q9BVE6

    Protein attributes for NIPAL3 Gene

    Size:
    406 amino acids
    Molecular mass:
    44742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NIPAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NIPAL3 Gene

Proteomics data for NIPAL3 Gene at MOPED

Post-translational modifications for NIPAL3 Gene

  • Glycosylation at Asn166
  • Modification sites at PhosphoSitePlus

Other Protein References for NIPAL3 Gene

No data available for DME Specific Peptides for NIPAL3 Gene

Domains for NIPAL3 Gene

Protein Domains for NIPAL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NIPAL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P499

UniProtKB/Swiss-Prot:

NPAL3_HUMAN :
  • Q6P499
Family:
  • Belongs to the NIPA family.
genes like me logo Genes that share domains with NIPAL3: view

No data available for Gene Families for NIPAL3 Gene

Function for NIPAL3 Gene

Gene Ontology (GO) - Molecular Function for NIPAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015095 magnesium ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with NIPAL3: view
genes like me logo Genes that share phenotypes with NIPAL3: view

Animal Models for NIPAL3 Gene

MGI Knock Outs for NIPAL3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIPAL3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NIPAL3 Gene

Localization for NIPAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIPAL3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIPAL3 Gene COMPARTMENTS Subcellular localization image for NIPAL3 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for NIPAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NIPAL3: view

Pathways for NIPAL3 Gene

SuperPathways for NIPAL3 Gene

No Data Available

Interacting Proteins for NIPAL3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363520%0d%0a9606.ENSP00000363680%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000363520 Q6P499-NPAL3_HUMAN for NIPAL3 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for NIPAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015693 magnesium ion transport IEA --
genes like me logo Genes that share ontologies with NIPAL3: view

No data available for Pathways by source for NIPAL3 Gene

Transcripts for NIPAL3 Gene

Unigene Clusters for NIPAL3 Gene

NIPA-like domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIPAL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIPAL3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - -
SP15: - - - - - - - - - - - - - - -
SP16: - - - - - - - - -
SP17: - -
SP18: - - - -
SP19: - - - - - - - - - - -
SP20: - - - -
SP21: - - - - - - -
SP22: - - -
SP23: -

ExUns: 9c · 9d ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: - - - - -
SP2: -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7: - -
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - - - -
SP20:
SP21:
SP22:
SP23:

Relevant External Links for NIPAL3 Gene

GeneLoc Exon Structure for
NIPAL3
ECgene alternative splicing isoforms for
NIPAL3

Expression for NIPAL3 Gene

mRNA expression in normal human tissues for NIPAL3 Gene

mRNA differential expression in normal tissues according to GTEx for NIPAL3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.6) and Brain - Cerebellar Hemisphere (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NIPAL3 Gene

SOURCE GeneReport for Unigene cluster for NIPAL3 Gene Hs.523442

genes like me logo Genes that share expressions with NIPAL3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NIPAL3 Gene

Orthologs for NIPAL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NIPAL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NIPAL3 35
  • 99.1 (n)
  • 99.26 (a)
NIPAL3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NIPAL3 35
  • 89 (n)
  • 93.84 (a)
NIPAL3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIPAL3 35
  • 90.39 (n)
  • 94.33 (a)
NIPAL3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nipal3 35
  • 85.71 (n)
  • 89.41 (a)
Nipal3 16
Nipal3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NIPAL3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIPAL3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nipal3 35
  • 86.62 (n)
  • 90.64 (a)
chicken
(Gallus gallus)
Aves NIPAL3 35
  • 74.88 (n)
  • 83.99 (a)
NIPAL3 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nipal3 35
  • 70.22 (n)
  • 74.72 (a)
zebrafish
(Danio rerio)
Actinopterygii nipal3 35
  • 66.57 (n)
  • 65.44 (a)
nipal3 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta spict 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipa-1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for NIPAL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIPAL3 Gene

ENSEMBL:
Gene Tree for NIPAL3 (if available)
TreeFam:
Gene Tree for NIPAL3 (if available)

Paralogs for NIPAL3 Gene

Paralogs for NIPAL3 Gene

Selected SIMAP similar genes for NIPAL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NIPAL3: view

Variants for NIPAL3 Gene

Sequence variations from dbSNP and Humsavar for NIPAL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15441 -- 24,472,555(+) ACCAA(A/T)CTTGG utr-variant-3-prime
rs195718 -- 24,457,707(-) AGAGC(A/G)GTGAG intron-variant
rs195719 -- 24,458,577(+) GGATA(C/T)GGGGG intron-variant
rs195720 -- 24,461,457(+) gaatc(A/G)cttga intron-variant
rs195721 -- 24,461,489(+) gtgac(C/T)cgaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NIPAL3 Gene

Variant ID Type Subtype PubMed ID
nsv469575 CNV Complex 16826518
nsv834447 CNV Loss 17160897
esv994910 CNV Insertion 20482838
esv2675642 CNV Deletion 23128226
nsv6965 CNV Loss 18451855

Relevant External Links for NIPAL3 Gene

HapMap Linkage Disequilibrium report
NIPAL3
Human Gene Mutation Database (HGMD)
NIPAL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIPAL3 Gene

Disorders for NIPAL3 Gene

No disorders were found for NIPAL3 Gene.

No data available for UniProtKB/Swiss-Prot for NIPAL3 Gene

Publications for NIPAL3 Gene

  1. Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function. (PMID: 19738379) Grzmil P. … Burfeind P. (Cytogenet. Genome Res. 2009) 3 23
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NIPAL3 Gene

Sources for NIPAL3 Gene

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