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NIPAL3 Gene

protein-coding   GIFtS: 48
GCID: GC01P024742

NIPA-Like Domain Containing 3


(Previous symbol: NPAL3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NIPA-Like Domain Containing 31 2
NPAL31 2 3
DJ462O23.22
NIPA-Like Protein 32

External Ids:    HGNC: 252331   Entrez Gene: 571852   Ensembl: ENSG000000014617   UniProtKB: Q6P4993   
ORGUL members:         

Export aliases for NIPAL3 gene to outside databases

Previous GC identifers: GC01P024616 GC01P022994


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NIPAL3 Gene:
NIPAL3 (NIPA-like domain containing 3) is a protein-coding gene. Diseases associated with NIPAL3 include paraplegia, and prader-willi syndrome. GO annotations related to this gene include magnesium ion transmembrane transporter activity. An important paralog of this gene is NIPA1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NIPAL3 gene promoter:
         POU3F2   Tal-1beta   CBF-C   E47   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNIPAL3 promoter sequence
   Search Chromatin IP Primers for NIPAL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NIPAL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12-p35.1   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.12-p35.1

NIPAL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NIPAL3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024742:  view genomic region     (about GC identifiers)

Start:
24,742,245 bp from pter      End:
24,799,473 bp from pter
Size:
57,229 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPAL3_HUMAN, Q6P499 (See protein sequence)
Recommended Name: NIPA-like protein 3  
Size: 406 amino acids; 44742 Da
Secondary accessions: A2A298 Q6MZT9 Q9BVE6
Alternative splicing: 3 isoforms:  Q6P499-1   Q6P499-2   Q6P499-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NIPAL3: NX_Q6P499

Explore proteomics data for NIPAL3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn166
  • Modification sites at PhosphoSitePlus

  • See NIPAL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065181.1  
    ENSEMBL proteins: 
     ENSP00000363520   ENSP00000003912   ENSP00000350722   ENSP00000343549   ENSP00000392170  
     ENSP00000406509  

    NIPAL3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NIPAL3

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    NIPAL3 Assay Products:

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    Cloud-Clone Corp. ELISAs for NIPAL3
    Cloud-Clone Corp. CLIAs for NIPAL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008521 Mg_trans_NIPA

    Graphical View of Domain Structure for InterPro Entry Q6P499

    ProtoNet protein and cluster: Q6P499

    UniProtKB/Swiss-Prot: NPAL3_HUMAN, Q6P499
    Similarity: Belongs to the NIPA family


    NIPAL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015095magnesium ion transmembrane transporter activity IEA--
         
    NIPAL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NIPAL3:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nipal3):
     behavior/neurological  hematopoietic system  immune system  no phenotypic analysis  respiratory system 

    NIPAL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nipal3tm1Pbfd for NIPAL3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NIPAL3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NIPAL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NIPAL3

    miRNA
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    Block miRNA regulation of human, mouse, rat NIPAL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NIPAL3 (see all 25):
    hsa-miR-3164 hsa-miR-579 hsa-miR-485-5p hsa-miR-495 hsa-miR-200a hsa-miR-488 hsa-miR-507 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidNIPAL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NIPAL3
    Predesigned siRNA for gene silencing in human, mouse, rat NIPAL3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NIPAL3

    Clone
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    OriGene clones in human, mouse for NIPAL3 (see all 7)
    OriGene ORF clones in mouse, rat for NIPAL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NIPAL3 (NM_020448)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NIPAL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIPAL3

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPAL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPAL3_HUMAN, Q6P499: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    NIPAL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NIPAL3
    Interactions:

        Search GeneGlobe Interaction Network for NIPAL3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NIPAL3 (ENSP000003635204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015693magnesium ion transport ----

    NIPAL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NIPAL3 (NPAL3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NIPAL3 gene: 
    NM_020448.4  

    Unigene Cluster for NIPAL3:

    NIPA-like domain containing 3
    Hs.523442  [show with all ESTs]
    Unigene Representative Sequence: NM_020448
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374399 ENST00000003912(uc001bjh.3 uc009vrc.3) ENST00000488155
    ENST00000358028(uc010oek.2) ENST00000339255 ENST00000475663 ENST00000432012(uc001bji.3)
    ENST00000428131
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NIPAL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NIPAL3 (see all 25):
    hsa-miR-3164 hsa-miR-579 hsa-miR-485-5p hsa-miR-495 hsa-miR-200a hsa-miR-488 hsa-miR-507 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidNIPAL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NIPAL3
    Predesigned siRNA for gene silencing in human, mouse, rat NIPAL3
    Clone
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    OriGene clones in human, mouse for NIPAL3 (see all 7)
    OriGene ORF clones in mouse, rat for NIPAL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NIPAL3 (NM_020448)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NIPAL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIPAL3
    Primer
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    OriGene qPCR primer pairs and template standards for NIPAL3
    OriGene qSTAR qPCR primer pairs in human, mouse for NIPAL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NIPAL3
      QuantiTect SYBR Green Assays in human, mouse, rat NIPAL3
      QuantiFast Probe-based Assays in human, mouse, rat NIPAL3

    Additional mRNA sequence: 

    AF131814.1 AK312433.1 BC001265.1 BC012492.1 BC063583.1 BX538110.1 BX640883.1 U90918.1 

    23 DOTS entries:

    DT.452592  DT.95266714  DT.97788070  DT.100809516  DT.97840433  DT.91963514  DT.434938  DT.100021524 
    DT.121450431  DT.121450448  DT.121450460  DT.121450547  DT.75143895  DT.87015286  DT.87016512  DT.95266716 
    DT.100776941  DT.121450424  DT.121450484  DT.121450532  DT.95360467  DT.205911  DT.65288409 

    Selected AceView cDNA sequences (see all 252):

    BE782849 CB111025 AI339789 AI360016 BM991434 BM264303 CA450060 AA988003 
    BM264000 CK824746 BU151260 BM983015 AU132886 CR626180 CB069159 AI087300 
    BX109422 CA434199 AI346784 CB242318 BM663615 BM981542 AU121578 BQ021167 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NIPAL3 (see all 23)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ·
    SP1:                                            -     -     -     -     -     -     -                                                     -     -     -     -   
    SP2:                                            -     -     -     -     -     -     -                                                     -     -     -     -   
    SP3:                                            -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                            -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 9c · 9d ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
    SP1:                                            -                                   -                                   -                       -     -         
    SP2:                                            -                                                                                                               
    SP3:                                            -                                   -                                   -                                       
    SP4:                                            -                                   -                                                                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for NIPAL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NIPAL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGCTGGG
    NIPAL3 Expression
    About this image

    NIPAL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NIPAL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523442
        Custom PCR Arrays for NIPAL3
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat NIPAL3
    QuantiFast Probe-based Assays in human, mouse, rat NIPAL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPAL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NIPAL3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nipal31 , 5 NIPA-like domain containing 31, 5 85.71(n)1
    89.41(a)1
      4 (67.64 cM)5
    745521  NM_028995.31  NP_083271.11 
     1354454205 
    chicken
    (Gallus gallus)
    Aves NIPAL31 NIPA-like domain containing 3 74.88(n)
    83.99(a)
      419697  XM_417843.4  XP_417843.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    24(a)
    many ↔ many
    GL343451.1(224191-231556)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC047987.12   -- 76.22(n)    BC047987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nipal31 NIPA-like domain containing 3 66.57(n)
    65.44(a)
      436907  NM_001002634.1  NP_001002634.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spict6
    spichthyin
    26(a)
    1 → many
    2L(12704725-12706683)
    worm
    (Caenorhabditis elegans)
    Secernentea nipa-16
    Protein NIPA-1, isoform b (nipa-1) mRNA, complete ...
    21(a)
    1 → many
    III(3112487-3127117) WBGene00021820


    ENSEMBL Gene Tree for NIPAL3 (if available)
    TreeFam Gene Tree for NIPAL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NIPAL3 gene
    NIPA12  NIPAL12  NIPAL22  NIPAL42  NIPA22  
    3 SIMAP similar genes for NIPAL3 using alignment to 3 protein entries:     NPAL3_HUMAN (see all proteins):
    DKFZp686E22155    NIPAL2    NPAL2

    NIPAL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NIPAL3 (see all 1156)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs66949321,2
    C,F,H--24743603(+) GACTGC/AGAAGG 1 -- int126Minor allele frequency- A:0.10NA NS EA WA CSA 2460
    rs1510253991,2
    --24743696(+) TAGATC/TTCATT 1 -- int10--------
    rs782002591,2
    C,F--24743762(+) GCTGGG/CAGCAA 1 -- int11Minor allele frequency- C:0.10WA 118
    rs7609671,2
    C,F,A,H--24743783(+) TATTCC/TGCAAA 1 -- int124Minor allele frequency- T:0.19NA NS EA 2676
    rs7609681,2
    C,F,O,A,H--24743879(+) CTGAGC/TCACTC 1 -- int127Minor allele frequency- T:0.19NA EA NS WA 3016
    rs1844535471,2
    --24744256(+) TATCAC/TATATG 1 -- int10--------
    rs1409367501,2
    --24744306(+) AGGGCC/TGGATA 1 -- int10--------
    rs1502117661,2
    C--24744310(+) CCGGAC/TAGCAG 1 -- int10--------
    rs1116572081,2
    F--24744322(+) AGGAAC/ATGGAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs753319781,2
    C,F--24744431(+) GCATGA/GGAGAG 1 -- int11Minor allele frequency- G:0.04EA 120

    HapMap Linkage Disequilibrium report for NIPAL3 (24742245 - 24799473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NIPAL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675642CNV Deletion23128226
    esv994910CNV Insertion20482838
    nsv834447CNV Loss17160897
    nsv6965CNV Loss18451855
    nsv469575CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for NIPAL3:    
    About MalaCards
    paraplegia    prader-willi syndrome    angelman syndrome    spasticity


    NIPAL3 for disorders           About GeneDecksing


    Export disorders for NIPAL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NIPAL3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with NIPAL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    4. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    5. Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function. (PubMed id 19738379)1, 9 Grzmil P....Burfeind P. (Cytogenet. Genome Res. 2009)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57185 HGNC: 25233 AceView: DJ462O23.2 Ensembl:ENSG00000001461 euGenes: HUgn57185
    ECgene: NIPAL3 H-InvDB: NIPAL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NIPAL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NIPAL3 gene:
    Search GeneIP for patents involving NIPAL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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