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Aliases for NIPAL3 Gene

Aliases for NIPAL3 Gene

  • NIPA Like Domain Containing 3 2 3
  • NIPA-Like Domain Containing 3 3 5
  • NPAL3 3 4
  • DJ462O23.2 3

External Ids for NIPAL3 Gene

Previous HGNC Symbols for NIPAL3 Gene

  • NPAL3

Previous GeneCards Identifiers for NIPAL3 Gene

  • GC01P024616
  • GC01P024742
  • GC01P022994

Summaries for NIPAL3 Gene

GeneCards Summary for NIPAL3 Gene

NIPAL3 (NIPA Like Domain Containing 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. GO annotations related to this gene include magnesium ion transmembrane transporter activity. An important paralog of this gene is NIPA2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIPAL3 Gene

Genomics for NIPAL3 Gene

Regulatory Elements for NIPAL3 Gene

Promoters for NIPAL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NIPAL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NIPAL3 Gene

Chromosome:
1
Start:
24,413,674 bp from pter
End:
24,472,983 bp from pter
Size:
59,310 bases
Orientation:
Plus strand

Genomic View for NIPAL3 Gene

Genes around NIPAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIPAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIPAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIPAL3 Gene

Proteins for NIPAL3 Gene

  • Protein details for NIPAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P499-NPAL3_HUMAN
    Recommended name:
    NIPA-like protein 3
    Protein Accession:
    Q6P499
    Secondary Accessions:
    • A2A298
    • Q6MZT9
    • Q9BVE6

    Protein attributes for NIPAL3 Gene

    Size:
    406 amino acids
    Molecular mass:
    44742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NIPAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NIPAL3 Gene

Proteomics data for NIPAL3 Gene at MOPED

Post-translational modifications for NIPAL3 Gene

  • Glycosylation at Asn 166
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NIPAL3 Gene

Domains & Families for NIPAL3 Gene

Protein Domains for NIPAL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NIPAL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P499

UniProtKB/Swiss-Prot:

NPAL3_HUMAN :
  • Belongs to the NIPA family.
Family:
  • Belongs to the NIPA family.
genes like me logo Genes that share domains with NIPAL3: view

No data available for Gene Families for NIPAL3 Gene

Function for NIPAL3 Gene

genes like me logo Genes that share phenotypes with NIPAL3: view

Animal Models for NIPAL3 Gene

MGI Knock Outs for NIPAL3:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NIPAL3 Gene

Localization for NIPAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIPAL3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIPAL3 Gene COMPARTMENTS Subcellular localization image for NIPAL3 gene
Compartment Confidence
plasma membrane 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for NIPAL3 Gene

Pathways & Interactions for NIPAL3 Gene

genes like me logo Genes that share pathways with NIPAL3: view

Pathways by source for NIPAL3 Gene

Interacting Proteins for NIPAL3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363520%0d%0a9606.ENSP00000363680%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000363520 Q6P499-NPAL3_HUMAN for NIPAL3 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for NIPAL3 Gene

None

No data available for SIGNOR curated interactions for NIPAL3 Gene

Drugs & Compounds for NIPAL3 Gene

No Compound Related Data Available

Transcripts for NIPAL3 Gene

Unigene Clusters for NIPAL3 Gene

NIPA-like domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NIPAL3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - -
SP15: - - - - - - - - - - - - - - -
SP16: - - - - - - - - -
SP17: - -
SP18: - - - -
SP19: - - - - - - - - - - -
SP20: - - - -
SP21: - - - - - - -
SP22: - - -
SP23: -

ExUns: 9c · 9d ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: - - - - -
SP2: -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7: - -
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - - - -
SP20:
SP21:
SP22:
SP23:

Relevant External Links for NIPAL3 Gene

GeneLoc Exon Structure for
NIPAL3
ECgene alternative splicing isoforms for
NIPAL3

Expression for NIPAL3 Gene

mRNA expression in normal human tissues for NIPAL3 Gene

mRNA differential expression in normal tissues according to GTEx for NIPAL3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for NIPAL3 Gene

This gene is overexpressed in Fetal Brain (35.6), Peripheral blood mononuclear cells (12.2), Kidney (10.8), and Ovary (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NIPAL3 Gene



SOURCE GeneReport for Unigene cluster for NIPAL3 Gene Hs.523442

genes like me logo Genes that share expression patterns with NIPAL3: view

Protein tissue co-expression partners for NIPAL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NIPAL3 Gene

Orthologs for NIPAL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NIPAL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NIPAL3 35
  • 99.1 (n)
  • 99.26 (a)
NIPAL3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NIPAL3 36
  • 94 (a)
OneToOne
NIPAL3 35
  • 89 (n)
  • 93.84 (a)
dog
(Canis familiaris)
Mammalia NIPAL3 35
  • 90.39 (n)
  • 94.33 (a)
NIPAL3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nipal3 16
Nipal3 35
  • 85.71 (n)
  • 89.41 (a)
Nipal3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NIPAL3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIPAL3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nipal3 35
  • 86.62 (n)
  • 90.64 (a)
chicken
(Gallus gallus)
Aves NIPAL3 35
  • 74.88 (n)
  • 83.99 (a)
NIPAL3 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nipal3 35
  • 70.22 (n)
  • 74.72 (a)
zebrafish
(Danio rerio)
Actinopterygii nipal3 36
  • 61 (a)
OneToOne
nipal3 35
  • 66.57 (n)
  • 65.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta spict 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipa-1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for NIPAL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIPAL3 Gene

ENSEMBL:
Gene Tree for NIPAL3 (if available)
TreeFam:
Gene Tree for NIPAL3 (if available)

Paralogs for NIPAL3 Gene

Paralogs for NIPAL3 Gene

(3) SIMAP similar genes for NIPAL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NIPAL3: view

Variants for NIPAL3 Gene

Sequence variations from dbSNP and Humsavar for NIPAL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs195723 -- 24,462,895(+) gagtt(C/T)gagac intron-variant
rs195724 -- 24,465,427(+) tgtgt(A/G)tatat intron-variant
rs878751 -- 24,418,580(+) CCAGC(C/T)TGGAT intron-variant
rs926459 -- 24,432,913(+) GGCAT(A/G)TGCCT intron-variant
rs926460 -- 24,432,939(+) CTCAC(A/G)ATGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NIPAL3 Gene

Variant ID Type Subtype PubMed ID
nsv469575 CNV Complex 16826518
nsv834447 CNV Loss 17160897
esv994910 CNV Insertion 20482838
esv2675642 CNV Deletion 23128226
nsv6965 CNV Loss 18451855

Variation tolerance for NIPAL3 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NIPAL3 Gene

HapMap Linkage Disequilibrium report
NIPAL3
Human Gene Mutation Database (HGMD)
NIPAL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIPAL3 Gene

Disorders for NIPAL3 Gene

Relevant External Links for NIPAL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NIPAL3

No disorders were found for NIPAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIPAL3 Gene

Publications for NIPAL3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function. (PMID: 19738379) Grzmil P. … Burfeind P. (Cytogenet. Genome Res. 2009) 3 23
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for NIPAL3 Gene

Sources for NIPAL3 Gene

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