NIPAL2 Gene
protein-coding GIFtS: 40
GCID: GC08M099278
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NIPA-like domain containing 2
(Previous symbol: NPAL2)
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Aliases
for NIPAL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NIPA-Like Domain Containing 21 2 | | NPAL21 2 3 | | FLJ139551 | | NIPA-Like Protein 22 |
Export aliases for NIPAL2 gene to outside databasesPrevious GC identifer: GC08M094407 |
Summaries
for NIPAL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NIPAL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NIPAL2 gene promoter:
USF1 AML1a Pax-2 Pax-2a POU6F1 (c2) GATA-1 POU2F1 POU2F1a USF-1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for NIPAL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIPAL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q22.2 Ensembl cytogenetic band: 8q22.2 HGNC cytogenetic band: 8q22.2NIPAL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M099278: view genomic region
(about GC identifiers)
Start:
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99,202,061 bp from pter |
End:
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99,306,621 bp from pter |
Size:
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104,561 bases |
Orientation:
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minus strand |
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Proteins
for NIPAL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPAL2_HUMAN, Q9H841 (See
protein sequence)Recommended Name: NIPA-like protein 2 Size: 368 amino acids; 40785 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for NIPAL2: NX_Q9H841
NIPAL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079035.1
ENSEMBL proteins: ENSP00000407087 ENSP00000339256
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
NIPAL2 for ontologies About GeneDecksing
NIPAL2 Antibody Products:
Assay Products for NIPAL2: |
Protein
Domains /
Families
for NIPAL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NIPAL2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H841ProtoNet protein and cluster: Q9H841 UniProtKB/Swiss-Prot: NPAL2_HUMAN, Q9H841Similarity: Belongs to the NIPA family |
Function
for NIPAL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIPAL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIPAL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NIPAL2 (NM_024759) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NIPAL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIPAL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPAL2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015095 | magnesium ion transmembrane transporter activity |
IEA | -- |
NIPAL2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NIPAL2:
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Pathways & Interactions
for NIPAL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NIPAL2
|
Drugs & Compounds
for NIPAL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NIPAL2
Search CenterWatch for drugs/clinical trials and news about NIPAL2 / NPAL2
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Transcripts
for NIPAL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NIPAL2 gene: NM_024759.1 Unigene Cluster for NIPAL2: NIPA-like domain containing 2 Hs.309489 [show with all ESTs]Unigene Representative Sequence: AK0250158 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000430223(uc011lgw.1) ENST00000341166(uc003yil.1 uc003yim.1)
ENST00000520545 ENST00000521820 ENST00000522188 ENST00000520735 ENST00000521949
ENST00000519324
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIPAL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIPAL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NIPAL2 (NM_024759) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NIPAL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIPAL2 |
Additional cDNA sequence: AK024017.1 AK025015.1 AK302414.1 BC132687.1 BC144055.1 6 DOTS entries: DT.310634 DT.102826671 DT.95151717 DT.91661773 DT.75136718 DT.97808849 24/78 AceView cDNA sequences (see all 78): AL704225 AI697643 AA424857 AA257079 NM_024759 BX101014 BU677761 CD723228 AI753382 AI753381 CA426282 AI247523 CA427789 AA705656 BF933249 AI458808 AI302784 BE217842 AK024017 CB151667 BU950319 BM798586 BE467942 BX957198
GeneLoc Exon Structure
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Expression
for NIPAL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NIPAL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTAGATTA
About this image
See NIPAL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NIPAL2
SOURCE GeneReport for Unigene cluster: Hs.309489
SABiosciences Custom PCR Arrays for NIPAL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIPAL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NIPAL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIPAL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIPAL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPAL2 |
Orthologs
for NIPAL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for NIPAL2 gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NPAL21 |
NIPA-like domain containing 2 |
70.87(n)
64.63(a) |
|
771428 XM_003640845.1 XP_003640893.1 |
lizard
(Anolis carolinensis) |
Reptilia |
NIPAL26 |
-- |
55(a) |
1 ↔ 1 |
4(20736528-20776852) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC537052 |
hypothetical protein MGC53705 |
71.05(n) |
|
BC043862.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01101136.16CABZ01118335.16 |
-- |
56(a)49(a) |
1 ↔ many1 ↔ many |
16(57957253-57958017) 16(58140440-58142865) |
ENSEMBL Gene Tree for NIPAL2 (if available)
TreeFam Gene Tree for NIPAL2 (if available) |
Paralogs
for NIPAL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NIPAL2 gene
- NIPA12 NIPAL32 NIPAL12 NIPA22 NIPAL42
5 SIMAP similar genes for NIPAL2 using alignment to 1 protein entry: NPAL2_HUMAN:NPAL2 NIPAL3 NIPAL4 NIPA2 NIPAL1
NIPAL2 for paralogs About GeneDecksing
|
Genomic Variants
for NIPAL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NIPAL2 (99202061 - 99306621 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NIPAL2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIPAL2 |
|
Disorders
/ Diseases
for NIPAL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NIPAL2 for disorders About GeneDecksing
2  diseases for NIPAL2: About MalaCardsautosomal recessive congenital ichthyosis ichthyosis
Export disorders for NIPAL2 gene to outside databases
|
Publications
for NIPAL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NIPAL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NIPAL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis. (PubMed id 15317751)1 Lefevre C.... Fischer J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NIPAL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NIPAL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NIPAL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NIPAL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NIPAL2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NIPAL2 gene:
Search GeneIP for patents involving NIPAL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NIPAL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NIPAL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NIPAL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIPAL2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NIPAL2 | | OriGene 3'-UTR Clone for NIPAL2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIPAL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIPAL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NIPAL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIPAL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIPAL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NIPAL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIPAL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIPAL2 |
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| | | | Search Tocris compounds for NIPAL2 |
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 | | | NIPAL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIPAL2 |
|  |  |  | | | | ThermoFisher Antibodies for NIPAL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIPAL2 |
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