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Aliases for NIPAL2 Gene

Aliases for NIPAL2 Gene

  • NIPA-Like Domain Containing 2 2 3
  • NPAL2 3 4
  • NIPA-Like Protein 2 3

External Ids for NIPAL2 Gene

Previous HGNC Symbols for NIPAL2 Gene

  • NPAL2

Previous GeneCards Identifiers for NIPAL2 Gene

  • GC08M099278
  • GC08M094407
  • GC08M099202

Summaries for NIPAL2 Gene

GeneCards Summary for NIPAL2 Gene

NIPAL2 (NIPA-Like Domain Containing 2) is a Protein Coding gene. Diseases associated with NIPAL2 include autosomal recessive congenital ichthyosis. GO annotations related to this gene include magnesium ion transmembrane transporter activity. An important paralog of this gene is NIPAL3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIPAL2 Gene

Genomics for NIPAL2 Gene

Regulatory Elements for NIPAL2 Gene

Genomic Location for NIPAL2 Gene

Start:
98,189,826 bp from pter
End:
98,295,216 bp from pter
Size:
105,391 bases
Orientation:
Minus strand

Genomic View for NIPAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIPAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIPAL2 Gene

Proteins for NIPAL2 Gene

  • Protein details for NIPAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H841-NPAL2_HUMAN
    Recommended name:
    NIPA-like protein 2
    Protein Accession:
    Q9H841
    Secondary Accessions:
    • A2RTY8

    Protein attributes for NIPAL2 Gene

    Size:
    368 amino acids
    Molecular mass:
    40785 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NIPAL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NIPAL2 Gene

Proteomics data for NIPAL2 Gene at MOPED

Post-translational modifications for NIPAL2 Gene

  • Glycosylation at Asn33 and Asn274

Other Protein References for NIPAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NIPAL2 Gene

Domains for NIPAL2 Gene

Protein Domains for NIPAL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NIPAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H841

UniProtKB/Swiss-Prot:

NPAL2_HUMAN :
  • Q9H841
Family:
  • Belongs to the NIPA family.
genes like me logo Genes that share domains with NIPAL2: view

No data available for Gene Families for NIPAL2 Gene

Function for NIPAL2 Gene

Gene Ontology (GO) - Molecular Function for NIPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015095 magnesium ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with NIPAL2: view

Phenotypes for NIPAL2 Gene

GenomeRNAi human phenotypes for NIPAL2:
genes like me logo Genes that share phenotypes with NIPAL2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NIPAL2 Gene

Localization for NIPAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIPAL2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIPAL2 Gene COMPARTMENTS Subcellular localization image for NIPAL2 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for NIPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NIPAL2: view

Pathways for NIPAL2 Gene

SuperPathways for NIPAL2 Gene

No Data Available

Interacting Proteins for NIPAL2 Gene

Gene Ontology (GO) - Biological Process for NIPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015693 magnesium ion transport IEA --
genes like me logo Genes that share ontologies with NIPAL2: view

No data available for Pathways by source for NIPAL2 Gene

Transcripts for NIPAL2 Gene

Unigene Clusters for NIPAL2 Gene

NIPA-like domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NIPAL2 Gene

No ASD Table

Relevant External Links for NIPAL2 Gene

GeneLoc Exon Structure for
NIPAL2
ECgene alternative splicing isoforms for
NIPAL2

Expression for NIPAL2 Gene

mRNA expression in normal human tissues for NIPAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NIPAL2 Gene

SOURCE GeneReport for Unigene cluster for NIPAL2 Gene Hs.309489

genes like me logo Genes that share expressions with NIPAL2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NIPAL2 Gene

Orthologs for NIPAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NIPAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NIPAL2 35
  • 99.04 (n)
  • 97.98 (a)
NIPAL2 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NIPAL2 35
  • 88.05 (n)
  • 87.57 (a)
NIPAL2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIPAL2 35
  • 85.82 (n)
  • 85.63 (a)
NIPAL2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nipal2 35
  • 84.31 (n)
  • 83.57 (a)
Nipal2 16
Nipal2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NIPAL2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIPAL2 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nipal2 35
  • 83.38 (n)
  • 83.57 (a)
chicken
(Gallus gallus)
Aves NIPAL2 35
  • 70.48 (n)
  • 62.6 (a)
NIPAL2 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIPAL2 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53705 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.496 35
zebrafish
(Danio rerio)
Actinopterygii NIPAL2 (1 of 2) 36
  • 49 (a)
OneToMany
NIPAL2 (2 of 2) 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta spict 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipa-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for NIPAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NIPAL2 Gene

ENSEMBL:
Gene Tree for NIPAL2 (if available)
TreeFam:
Gene Tree for NIPAL2 (if available)

Paralogs for NIPAL2 Gene

Paralogs for NIPAL2 Gene

Selected SIMAP similar genes for NIPAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NIPAL2: view

Variants for NIPAL2 Gene

Sequence variations from dbSNP and Humsavar for NIPAL2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs896419 -- 98,282,744(-) GCATT(A/C)CGGTA intron-variant
rs896420 -- 98,282,742(-) ATTCC(C/G)GTAGT intron-variant
rs896421 -- 98,228,381(+) CACCC(A/G)CAGAA intron-variant
rs1063249 -- 98,189,831(-) TCAAG(A/C)AGTGA utr-variant-3-prime
rs1129891 -- 98,190,359(-) GGCGA(C/T)AGAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NIPAL2 Gene

Variant ID Type Subtype PubMed ID
nsv831405 CNV Gain 17160897
nsv891216 CNV Loss 21882294
nsv6326 CNV Loss 18451855
esv2669746 CNV Deletion 23128226
esv2737348 CNV Deletion 23290073
nsv397166 CNV Loss 16902084
esv1594433 CNV Deletion 17803354
esv2659931 CNV Deletion 23128226
esv2656906 CNV Deletion 23128226
nsv831406 CNV Loss 17160897

Relevant External Links for NIPAL2 Gene

HapMap Linkage Disequilibrium report
NIPAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIPAL2 Gene

Disorders for NIPAL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NIPAL2 Gene including...

Search for NIPAL2 Gene in MalaCards »
genes like me logo Genes that share disorders with NIPAL2: view

No data available for UniProtKB/Swiss-Prot for NIPAL2 Gene

Publications for NIPAL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Mutations in ichthyin a new gene on chromosome 5q33 in a new form of autosomal recessive congenital ichthyosis. (PMID: 15317751) Lefevre C. … Fischer J. (Hum. Mol. Genet. 2004) 3
  3. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4

Products for NIPAL2 Gene

  • antibodies-online peptides for NIPAL2
  • antibodies-online antibodies for NIPAL2
  • antibodies-online kits for NIPAL2

Sources for NIPAL2 Gene

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