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Aliases for NIPAL1 Gene

Aliases for NIPAL1 Gene

  • NIPA-Like Domain Containing 1 2 3
  • Non-Imprinted In Prader-Willi/Angelman Syndrome Region Protein 3 3 4
  • NIPA-Like Protein 1 3 4
  • NPAL1 3 4
  • Magnesium Transporter NIPA3 3
  • NIPA3 4

External Ids for NIPAL1 Gene

Previous HGNC Symbols for NIPAL1 Gene

  • NPAL1

Previous GeneCards Identifiers for NIPAL1 Gene

  • GC04P047714
  • GC04P048018
  • GC04P047339

Summaries for NIPAL1 Gene

GeneCards Summary for NIPAL1 Gene

NIPAL1 (NIPA-Like Domain Containing 1) is a Protein Coding gene. Diseases associated with NIPAL1 include angelman syndrome. GO annotations related to this gene include magnesium ion transmembrane transporter activity. An important paralog of this gene is NIPAL3.

UniProtKB/Swiss-Prot for NIPAL1 Gene

  • Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIPAL1 Gene

Genomics for NIPAL1 Gene

Regulatory Elements for NIPAL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NIPAL1 Gene

Start:
47,914,142 bp from pter
End:
48,040,173 bp from pter
Size:
126,032 bases
Orientation:
Plus strand

Genomic View for NIPAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIPAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIPAL1 Gene

Proteins for NIPAL1 Gene

  • Protein details for NIPAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NVV3-NIPA3_HUMAN
    Recommended name:
    Magnesium transporter NIPA3
    Protein Accession:
    Q6NVV3
    Secondary Accessions:
    • B3KTB0
    • Q68DA9

    Protein attributes for NIPAL1 Gene

    Size:
    410 amino acids
    Molecular mass:
    44638 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NIPAL1 Gene

Proteomics data for NIPAL1 Gene at MOPED

Post-translational modifications for NIPAL1 Gene

  • Glycosylation at Asn25, Asn35, Asn50, and Asn55
  • Modification sites at PhosphoSitePlus

Other Protein References for NIPAL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NIPAL1 Gene

Domains for NIPAL1 Gene

Protein Domains for NIPAL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NIPAL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NVV3

UniProtKB/Swiss-Prot:

NIPA3_HUMAN :
  • Q6NVV3
Family:
  • Belongs to the NIPA family.
genes like me logo Genes that share domains with NIPAL1: view

No data available for Gene Families for NIPAL1 Gene

Function for NIPAL1 Gene

Molecular function for NIPAL1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).

Gene Ontology (GO) - Molecular Function for NIPAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015095 magnesium ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with NIPAL1: view

Phenotypes for NIPAL1 Gene

GenomeRNAi human phenotypes for NIPAL1:
genes like me logo Genes that share phenotypes with NIPAL1: view

Animal Model Products

CRISPR Products

miRNA for NIPAL1 Gene

miRTarBase miRNAs that target NIPAL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIPAL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NIPAL1 Gene

Localization for NIPAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIPAL1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIPAL1 Gene COMPARTMENTS Subcellular localization image for NIPAL1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for NIPAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NIPAL1: view

Pathways for NIPAL1 Gene

SuperPathways for NIPAL1 Gene

No Data Available

Interacting Proteins for NIPAL1 Gene

Gene Ontology (GO) - Biological Process for NIPAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015693 magnesium ion transport IEA --
genes like me logo Genes that share ontologies with NIPAL1: view

No data available for Pathways by source for NIPAL1 Gene

Transcripts for NIPAL1 Gene

Unigene Clusters for NIPAL1 Gene

NIPA-like domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIPAL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIPAL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2: -
SP3: -
SP4: - - - -

Relevant External Links for NIPAL1 Gene

GeneLoc Exon Structure for
NIPAL1
ECgene alternative splicing isoforms for
NIPAL1

Expression for NIPAL1 Gene

mRNA expression in normal human tissues for NIPAL1 Gene

mRNA differential expression in normal tissues according to GTEx for NIPAL1 Gene

This gene is overexpressed in Esophagus - Mucosa (10.6), Skin - Sun Exposed (Lower leg) (8.5), Skin - Not Sun Exposed (Suprapubic) (8.0), and Colon - Transverse (5.2).

Protein differential expression in normal tissues for NIPAL1 Gene

This gene is overexpressed in Ovary (49.0) and Spleen (16.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NIPAL1 Gene

SOURCE GeneReport for Unigene cluster for NIPAL1 Gene Hs.134190

genes like me logo Genes that share expressions with NIPAL1: view

Expression partners for NIPAL1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NIPAL1 Gene

Orthologs for NIPAL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIPAL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NIPAL1 35
  • 88.56 (n)
  • 88.24 (a)
NIPAL1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIPAL1 35
  • 90.49 (n)
  • 91.71 (a)
NIPAL1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nipal1 35
  • 84.96 (n)
  • 87.07 (a)
Nipal1 16
Nipal1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NIPAL1 35
  • 99.84 (n)
  • 100 (a)
NIPAL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nipal1 35
  • 85.76 (n)
  • 88.49 (a)
oppossum
(Monodelphis domestica)
Mammalia NIPAL1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIPAL1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves NIPAL1 35
  • 70.99 (n)
  • 70.54 (a)
NIPAL1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIPAL1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nipal1 35
  • 66.26 (n)
  • 71.25 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:101583 36
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta spict 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nipa-1 36
  • 44 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.6171 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for NIPAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIPAL1 Gene

ENSEMBL:
Gene Tree for NIPAL1 (if available)
TreeFam:
Gene Tree for NIPAL1 (if available)

Paralogs for NIPAL1 Gene

Paralogs for NIPAL1 Gene

Selected SIMAP similar genes for NIPAL1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NIPAL1 Gene

genes like me logo Genes that share paralogs with NIPAL1: view

Variants for NIPAL1 Gene

Sequence variations from dbSNP and Humsavar for NIPAL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs224799 -- 48,019,908(+) TCAAC(A/C)CCTCA intron-variant
rs321621 -- 48,021,556(+) TTTGT(A/G)GGACC intron-variant
rs321622 -- 48,022,363(+) GATTT(C/T)TATTA intron-variant
rs321623 -- 48,022,548(+) AGATC(C/T)ACCCA intron-variant
rs1396051 -- 48,033,529(+) ATTTT(C/T)CTCAT intron-variant

Relevant External Links for NIPAL1 Gene

HapMap Linkage Disequilibrium report
NIPAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NIPAL1 Gene

Disorders for NIPAL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NIPAL1 Gene in MalaCards »

(1) Diseases for NIPAL1 Gene including...

genes like me logo Genes that share disorders with NIPAL1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NIPAL1 Gene

Publications for NIPAL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NIPAL1 Gene

Sources for NIPAL1 Gene

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