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Aliases for NIP7 Gene

Aliases for NIP7 Gene

  • NIP7, Nucleolar Pre-RRNA Processing Protein 2 3 5
  • KD93 3 4
  • Nuclear Import 7 Homolog (S. Cerevisiae) 2
  • Nuclear Import 7 Homolog 3
  • HSPC031 3
  • CGI-37 3

External Ids for NIP7 Gene

Previous GeneCards Identifiers for NIP7 Gene

  • GC16P067932
  • GC16P055252

Summaries for NIP7 Gene

GeneCards Summary for NIP7 Gene

NIP7 (NIP7, Nucleolar Pre-RRNA Processing Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for NIP7 Gene

  • Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.

Gene Wiki entry for NIP7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIP7 Gene

Genomics for NIP7 Gene

Regulatory Elements for NIP7 Gene

Enhancers for NIP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NIP7 on UCSC Golden Path with GeneCards custom track

Promoters for NIP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NIP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for NIP7 Gene

69,339,430 bp from pter
69,343,111 bp from pter
3,682 bases
Plus strand

Genomic View for NIP7 Gene

Genes around NIP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIP7 Gene

Proteins for NIP7 Gene

  • Protein details for NIP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosome subunit biogenesis protein NIP7 homolog
    Protein Accession:
    Secondary Accessions:
    • B2RD04
    • Q9NZZ0

    Protein attributes for NIP7 Gene

    180 amino acids
    Molecular mass:
    20463 Da
    Quaternary structure:
    • Monomer. Interacts with pre-ribosome complex. May bind to RNA (By similarity). Interacts with NOL8. May interact with SBDS. Interacts with FTSJ3.

    Three dimensional structures from OCA and Proteopedia for NIP7 Gene

    Alternative splice isoforms for NIP7 Gene


neXtProt entry for NIP7 Gene

Proteomics data for NIP7 Gene at MOPED

Post-translational modifications for NIP7 Gene

  • Ubiquitination at Lys 50, Lys 94, Lys 115, and Lys 155
  • Modification sites at PhosphoSitePlus

Other Protein References for NIP7 Gene

No data available for DME Specific Peptides for NIP7 Gene

Domains & Families for NIP7 Gene

Suggested Antigen Peptide Sequences for NIP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PUA domain.
  • Belongs to the NIP7 family.
  • Contains 1 PUA domain.
  • Belongs to the NIP7 family.
genes like me logo Genes that share domains with NIP7: view

No data available for Gene Families for NIP7 Gene

Function for NIP7 Gene

Molecular function for NIP7 Gene

UniProtKB/Swiss-Prot Function:
Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
genes like me logo Genes that share phenotypes with NIP7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NIP7 Gene

Localization for NIP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIP7 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for NIP7 Gene COMPARTMENTS Subcellular localization image for NIP7 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NIP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NIP7: view

Pathways & Interactions for NIP7 Gene

SuperPathways for NIP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIP7 Gene


No data available for Pathways by source and SIGNOR curated interactions for NIP7 Gene

Drugs & Compounds for NIP7 Gene

No Compound Related Data Available

Transcripts for NIP7 Gene

Unigene Clusters for NIP7 Gene

NIP7, nucleolar pre-rRNA processing protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NIP7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for NIP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NIP7 Gene

mRNA expression in normal human tissues for NIP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NIP7 Gene

This gene is overexpressed in Monocytes (21.1), Lung (9.1), Pancreas (7.5), and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NIP7 Gene

SOURCE GeneReport for Unigene cluster for NIP7 Gene Hs.585728

mRNA Expression by UniProt/SwissProt for NIP7 Gene

Tissue specificity: Expressed in hematopoietic stem/progenitor cells.
genes like me logo Genes that share expression patterns with NIP7: view

Protein tissue co-expression partners for NIP7 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for NIP7 Gene

Orthologs for NIP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NIP7 35
  • 90.74 (n)
  • 98.33 (a)
NIP7 36
  • 98 (a)
(Canis familiaris)
Mammalia NIP7 35
  • 91.48 (n)
  • 96.11 (a)
NIP7 36
  • 91 (a)
(Mus musculus)
Mammalia Nip7 35
  • 87.04 (n)
  • 97.78 (a)
Nip7 16
Nip7 36
  • 98 (a)
(Pan troglodytes)
Mammalia NIP7 35
  • 100 (n)
  • 100 (a)
NIP7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nip7 35
  • 88.15 (n)
  • 97.22 (a)
(Monodelphis domestica)
Mammalia NIP7 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia NIP7 36
  • 90 (a)
(Gallus gallus)
Aves NIP7 35
  • 77.96 (n)
  • 85.56 (a)
NIP7 36
  • 81 (a)
(Anolis carolinensis)
Reptilia NIP7 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nip7 35
  • 77.41 (n)
  • 90 (a)
Str.10336 35
(Danio rerio)
Actinopterygii Dr.16108 35
nip7 35
  • 73.52 (n)
  • 82.22 (a)
nip7 36
  • 82 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6718 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002330 35
  • 64.43 (n)
  • 67.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7006 35
  • 63.5 (n)
  • 64.8 (a)
CG7006 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea C43E11.9 35
  • 59.22 (n)
  • 61.45 (a)
C43E11.9 36
  • 61 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL104W 35
  • 60.15 (n)
  • 59.78 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02266g 35
  • 59.22 (n)
  • 59.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP7 35
  • 56.98 (n)
  • 56.98 (a)
NIP7 36
  • 56 (a)
NIP7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G15770 35
  • 61.64 (n)
  • 62.01 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.383 35
(Oryza sativa)
Liliopsida Os07g0670600 35
  • 55.87 (n)
  • 55.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6681 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00105 35
  • 53.45 (n)
  • 53.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC320.11c 35
  • 64.06 (n)
  • 64.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5575 36
  • 74 (a)
Species with no ortholog for NIP7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIP7 Gene

Gene Tree for NIP7 (if available)
Gene Tree for NIP7 (if available)

Paralogs for NIP7 Gene Pseudogenes for NIP7 Gene

genes like me logo Genes that share paralogs with NIP7: view

No data available for Paralogs for NIP7 Gene

Variants for NIP7 Gene

Sequence variations from dbSNP and Humsavar for NIP7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_036488 A breast cancer sample
rs80014992 -- 69,342,447(+) AAAAA(A/T)ATTAG utr-variant-3-prime
rs117718454 -- 69,342,689(+) TATTC(C/T)TGTTA utr-variant-3-prime
rs72795286 -- 69,342,010(+) TATTA(A/G)TATGC utr-variant-3-prime
rs11540992 -- 69,342,366(+) AAGGC(A/G)GACGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NIP7 Gene

Variant ID Type Subtype PubMed ID
nsv906820 CNV Loss 21882294
nsv827715 CNV Loss 20364138

Variation tolerance for NIP7 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NIP7 Gene

Disorders for NIP7 Gene

Relevant External Links for NIP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NIP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIP7 Gene

Publications for NIP7 Gene

  1. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. (PMID: 22195017) Morello L.G. … Zanchin N.I. (PLoS ONE 2011) 2 3 4 67
  2. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PMID: 14660641) Sekiguchi T. … Nishimoto T. (J. Biol. Chem. 2004) 2 3
  3. Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells. (PMID: 15522784) Liu J.-F. … Liang D.-C. (J. Struct. Biol. 2004) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NIP7 Gene

Sources for NIP7 Gene