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Aliases for NIP7 Gene

Aliases for NIP7 Gene

  • NIP7, Nucleolar Pre-RRNA Processing Protein 2 3 5
  • KD93 3 4
  • 60S Ribosome Subunit Biogenesis Protein NIP7 Homolog 3
  • Nuclear Import 7 Homolog (S. Cerevisiae) 2
  • Nuclear Import 7 Homolog 3
  • HSPC031 3
  • CGI-37 3

External Ids for NIP7 Gene

Previous GeneCards Identifiers for NIP7 Gene

  • GC16P067932
  • GC16P055252

Summaries for NIP7 Gene

GeneCards Summary for NIP7 Gene

NIP7 (NIP7, Nucleolar Pre-RRNA Processing Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for NIP7 Gene

  • Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.

Gene Wiki entry for NIP7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIP7 Gene

Genomics for NIP7 Gene

Regulatory Elements for NIP7 Gene

Enhancers for NIP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NIP7 on UCSC Golden Path with GeneCards custom track

Promoters for NIP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NIP7 Gene

Chromosome:
16
Start:
69,339,430 bp from pter
End:
69,343,111 bp from pter
Size:
3,682 bases
Orientation:
Plus strand

Genomic View for NIP7 Gene

Genes around NIP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIP7 Gene

Proteins for NIP7 Gene

  • Protein details for NIP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y221-NIP7_HUMAN
    Recommended name:
    60S ribosome subunit biogenesis protein NIP7 homolog
    Protein Accession:
    Q9Y221
    Secondary Accessions:
    • B2RD04
    • Q9NZZ0

    Protein attributes for NIP7 Gene

    Size:
    180 amino acids
    Molecular mass:
    20463 Da
    Quaternary structure:
    • Monomer. Interacts with pre-ribosome complex. May bind to RNA (By similarity). Interacts with NOL8. May interact with SBDS. Interacts with FTSJ3.

    Three dimensional structures from OCA and Proteopedia for NIP7 Gene

    Alternative splice isoforms for NIP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NIP7 Gene

Post-translational modifications for NIP7 Gene

  • Ubiquitination at Lys 50, Lys 94, Lys 115, and Lys 155
  • Modification sites at PhosphoSitePlus

Other Protein References for NIP7 Gene

No data available for DME Specific Peptides for NIP7 Gene

Domains & Families for NIP7 Gene

Suggested Antigen Peptide Sequences for NIP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y221

UniProtKB/Swiss-Prot:

NIP7_HUMAN :
  • Contains 1 PUA domain.
  • Belongs to the NIP7 family.
Domain:
  • Contains 1 PUA domain.
Family:
  • Belongs to the NIP7 family.
genes like me logo Genes that share domains with NIP7: view

No data available for Gene Families for NIP7 Gene

Function for NIP7 Gene

Molecular function for NIP7 Gene

UniProtKB/Swiss-Prot Function:
Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.

Gene Ontology (GO) - Molecular Function for NIP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14660641
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NIP7: view
genes like me logo Genes that share phenotypes with NIP7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NIP7 Gene

Localization for NIP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIP7 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIP7 Gene COMPARTMENTS Subcellular localization image for NIP7 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NIP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with NIP7: view

Pathways & Interactions for NIP7 Gene

SuperPathways for NIP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042255 ribosome assembly IEA --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with NIP7: view

No data available for Pathways by source and SIGNOR curated interactions for NIP7 Gene

Drugs & Compounds for NIP7 Gene

No Compound Related Data Available

Transcripts for NIP7 Gene

Unigene Clusters for NIP7 Gene

NIP7, nucleolar pre-rRNA processing protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIP7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for NIP7 Gene

GeneLoc Exon Structure for
NIP7
ECgene alternative splicing isoforms for
NIP7

Expression for NIP7 Gene

mRNA expression in normal human tissues for NIP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NIP7 Gene

This gene is overexpressed in Monocytes (21.1), Lung (9.1), Pancreas (7.5), and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NIP7 Gene



Protein tissue co-expression partners for NIP7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NIP7 Gene:

NIP7

SOURCE GeneReport for Unigene cluster for NIP7 Gene:

Hs.585728

mRNA Expression by UniProt/SwissProt for NIP7 Gene:

Q9Y221-NIP7_HUMAN
Tissue specificity: Expressed in hematopoietic stem/progenitor cells.
genes like me logo Genes that share expression patterns with NIP7: view

Primer Products

No data available for mRNA differential expression in normal tissues for NIP7 Gene

Orthologs for NIP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NIP7 34
  • 90.74 (n)
  • 98.33 (a)
NIP7 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIP7 34
  • 91.48 (n)
  • 96.11 (a)
NIP7 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nip7 34
  • 87.04 (n)
  • 97.78 (a)
Nip7 16
Nip7 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NIP7 34
  • 100 (n)
  • 100 (a)
NIP7 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nip7 34
  • 88.15 (n)
  • 97.22 (a)
oppossum
(Monodelphis domestica)
Mammalia NIP7 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIP7 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NIP7 34
  • 77.96 (n)
  • 85.56 (a)
NIP7 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIP7 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nip7 34
  • 77.41 (n)
  • 90 (a)
Str.10336 34
zebrafish
(Danio rerio)
Actinopterygii Dr.16108 34
nip7 34
  • 73.52 (n)
  • 82.22 (a)
nip7 35
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6718 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002330 34
  • 64.43 (n)
  • 67.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7006 34
  • 63.5 (n)
  • 64.8 (a)
CG7006 35
  • 64 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C43E11.9 34
  • 59.22 (n)
  • 61.45 (a)
C43E11.9 35
  • 61 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL104W 34
  • 60.15 (n)
  • 59.78 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02266g 34
  • 59.22 (n)
  • 59.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP7 34
  • 56.98 (n)
  • 56.98 (a)
NIP7 35
  • 56 (a)
OneToOne
NIP7 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G15770 34
  • 61.64 (n)
  • 62.01 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.383 34
rice
(Oryza sativa)
Liliopsida Os07g0670600 34
  • 55.87 (n)
  • 55.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6681 34
bread mold
(Neurospora crassa)
Ascomycetes NCU00105 34
  • 53.45 (n)
  • 53.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC320.11c 34
  • 64.06 (n)
  • 64.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5575 35
  • 74 (a)
OneToOne
Species where no ortholog for NIP7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIP7 Gene

ENSEMBL:
Gene Tree for NIP7 (if available)
TreeFam:
Gene Tree for NIP7 (if available)

Paralogs for NIP7 Gene

Pseudogenes.org Pseudogenes for NIP7 Gene

genes like me logo Genes that share paralogs with NIP7: view

No data available for Paralogs for NIP7 Gene

Variants for NIP7 Gene

Sequence variations from dbSNP and Humsavar for NIP7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_036488 A breast cancer sample
rs11540992 -- 69,342,366(+) AAGGC(A/G)GACGG utr-variant-3-prime
rs72795286 -- 69,342,010(+) TATTA(A/G)TATGC utr-variant-3-prime
rs112803243 -- 69,342,026(+) AGACA(C/T)TGCCA utr-variant-3-prime
rs58641063 -- 69,342,247(+) TGAAA(A/G)TCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NIP7 Gene

Variant ID Type Subtype PubMed ID
nsv827715 CNV loss 20364138

Variation tolerance for NIP7 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NIP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NIP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIP7 Gene

Disorders for NIP7 Gene

Relevant External Links for NIP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NIP7

No disorders were found for NIP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIP7 Gene

Publications for NIP7 Gene

  1. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. (PMID: 22195017) Morello L.G. … Zanchin N.I. (PLoS ONE 2011) 2 3 4 65
  2. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PMID: 14660641) Sekiguchi T. … Nishimoto T. (J. Biol. Chem. 2004) 2 3 4 65
  3. Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells. (PMID: 15522784) Liu J.-F. … Liang D.-C. (J. Struct. Biol. 2004) 3 4 22 65
  4. The NIP7 protein is required for accurate pre-rRNA processing in human cells. (PMID: 20798176) Morello L.G. … Zanchin N.I. (Nucleic Acids Res. 2011) 2 3 65
  5. The Shwachman-Bodian-Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels. (PMID: 17643419) Hesling C. … Zanchin N.I. (Exp. Cell Res. 2007) 3 4 65

Products for NIP7 Gene

Sources for NIP7 Gene

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