NIP7 Gene
protein-coding GIFtS: 49
GCID: GC16P069373
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|
nuclear import 7 homolog (S. cerevisiae)
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Aliases
for NIP7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Import 7 Homolog (S. Cerevisiae)1 2 | | KD931 2 3 | | HSPC0311 2 | | CGI-371 | | FLJ102961 | | 60S Ribosome Subunit Biogenesis Protein NIP7 Homolog2 |
Export aliases for NIP7 gene to outside databasesPrevious GC identifers: GC16P067932 GC16P055252 |
Summaries
for NIP7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NIP7_HUMAN, Q9Y221Function: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly
Gene Wiki entry for NIP7
|
Genomic Views
for NIP7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NIP7 gene promoter:
AML1a p53 CUTL1 NF-AT HEN1 CBF-B CBF-A CP1A CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for NIP7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIP7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1NIP7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P069373: view genomic region
(about GC identifiers)
Start:
|
69,373,333 bp from pter |
End:
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69,377,014 bp from pter |
Size:
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3,682 bases |
Orientation:
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plus strand |
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Proteins
for NIP7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NIP7_HUMAN, Q9Y221 (See
protein sequence)Recommended Name: 60S ribosome subunit biogenesis protein NIP7 homolog Size: 180 amino acids; 20463 Da
Subunit: Monomer. Interacts with pre-ribosome complex. May bind to RNA (By similarity). Interacts with NOL8. Mayinteract with SBDS. Interacts with FTSJ3
Subcellular location: Nucleus, nucleolus
2 PDB 3D structures from  and Proteopedia  for NIP7:1SQW (3D)
1T5Y (3D)
Secondary accessions: B2RD04 Q9NZZ0Alternative splicing: 2 isoforms: Q9Y221-1 Q9Y221-2 Explore the universe of human proteins at neXtProt for NIP7: NX_Q9Y221
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y221
NIP7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001186363.1 NP_057185.1
ENSEMBL proteins: ENSP00000254940 ENSP00000463739 ENSP00000254941 ENSP00000464348 ENSP00000464159
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
NIP7 for ontologies About GeneDecksing
NIP7 Antibody Products:
Assay Products for NIP7: |
Protein
Domains /
Families
for NIP7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NIP7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y221ProtoNet protein and cluster: Q9Y221 1 Blocks protein family: IPB005155 Protein of unknown function UPF0113
UniProtKB/Swiss-Prot: NIP7_HUMAN, Q9Y221Similarity: Belongs to the NIP7 familySimilarity: Contains 1 PUA domain |
Function
for NIP7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NIP7_HUMAN, Q9Y221Function: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIP7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIP7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NIP7 (NM_016101) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NIP7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIP7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIP7 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NIP7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NIP7:
|
Pathways & Interactions
for NIP7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NIP7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/159 Interacting proteins for NIP7 (Q9Y2212, 3 ENSP000002549404) via UniProtKB, MINT, STRING, and/or I2D (see all 159)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042255 | ribosome assembly |
IEA | -- |
NIP7 for ontologies About GeneDecksing
|
Drugs & Compounds
for NIP7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NIP7
Search CenterWatch for drugs/clinical trials and news about NIP7
|
Transcripts
for NIP7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NIP7 gene (2 alternative transcripts): NM_001199434.1 NM_016101.4 Unigene Cluster for NIP7: Nuclear import 7 homolog (S. cerevisiae) Hs.744220 [show with all ESTs]Unigene Representative Sequence: NM_0161018 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000254940(uc002exa.3 uc002exb.3) ENST00000569637 ENST00000254941
ENST00000565034 ENST00000563364 ENST00000562131 ENST00000567202 ENST00000562523
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIP7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIP7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NIP7 (NM_016101) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NIP7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIP7 |
Additional cDNA sequence: AB062398.1 AB062479.1 AB112439.2 AF085360.1 AF132971.1 AF161528.1 AK001158.1 AK315355.1 BC015941.1 12 DOTS entries: DT.99940751 DT.100792560 DT.100792562 DT.92357140 DT.444010 DT.308282 DT.97764702 DT.120681196 DT.92438398 DT.107080 DT.120680952 DT.100027117 24/192 AceView cDNA sequences (see all 192): C21492 AI037850 CA397266 BQ422180 AI561054 BG231819 AB062398 AB062479 CB112901 AF132971 BM700127 AA311618 CB117687 AW001672 BM785485 AA045270 AL551662 BQ777214 AI244785 CB139809 BM670140 BM786912 AA883788 BQ049280
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NIP7 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|
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| SP1: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for NIP7
|
Expression
for NIP7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NIP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGTGGTCC
About this image
See NIP7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NIP7
SOURCE GeneReport for Unigene cluster: Hs.744220
UniProtKB/Swiss-Prot: NIP7_HUMAN, Q9Y221Tissue specificity: Expressed in hematopoietic stem/progenitor cells
SABiosciences Custom PCR Arrays for NIP7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIP7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NIP7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIP7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIP7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIP7 |
Orthologs
for NIP7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NIP7 gene from 10/34 species (see all 34) About this table
ENSEMBL Gene Tree for NIP7 (if available)
TreeFam Gene Tree for NIP7 (if available) |
Paralogs
for NIP7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NIP7 gene
NIP7 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for NIP7
PGOHUM00000238587 PGOHUM00000238193 PGOHUM00000243337
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Genomic Variants
for NIP7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NIP7 (69373333 - 69377014 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NIP7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIP7 |
|
Disorders
/ Diseases
for NIP7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NIP7 for disorders About GeneDecksing
2  diseases for NIP7: About MalaCardsnorth american indian childhood cirrhosis malaria
Export disorders for NIP7 gene to outside databases
|
Publications
for NIP7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NIP7 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with NIP7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PubMed id 14660641)1, 2, 3 Sekiguchi T....Nishimoto T. (2004)
- Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells. (PubMed id 15522784)1, 2, 9 Liu J.-F.... Liang D.-C. (2004)
- The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. (PubMed id 22195017)1, 2 Morello L.G....Zanchin N.I. (2011)
- The Shwachman-Bodian-Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels. (PubMed id 17643419)1, 2 Hesling C....Zanchin N.I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for NIP7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NIP7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NIP7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NIP7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NIP7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NIP7 gene:
Search GeneIP for patents involving NIP7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NIP7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NIP7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NIP7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIP7 | | | OriGene Protein Over-expression Lysate for NIP7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NIP7 | | OriGene 3'-UTR Clone for NIP7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIP7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIP7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NIP7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NIP7 | | OriGene Custom Protein Services for NIP7 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NIP7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIP7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIP7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NIP7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIP7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIP7 |
| |
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| | | | Search Tocris compounds for NIP7 |
| |  |  |  |  | | | | | | Recombinant Protein for NIP7 |
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 | | | NIP7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIP7 |
|  |  |  | | | | Search ThermoFisher Antibodies for NIP7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIP7 |
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