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Aliases for NIP7 Gene

Aliases for NIP7 Gene

  • NIP7, Nucleolar Pre-RRNA Processing Protein 2 3
  • KD93 3 4
  • 60S Ribosome Subunit Biogenesis Protein NIP7 Homolog 3
  • Nuclear Import 7 Homolog (S. Cerevisiae) 2
  • Nuclear Import 7 Homolog 3
  • HSPC031 3
  • CGI-37 3

External Ids for NIP7 Gene

Previous GeneCards Identifiers for NIP7 Gene

  • GC16P067932
  • GC16P055252

Summaries for NIP7 Gene

GeneCards Summary for NIP7 Gene

NIP7 (NIP7, Nucleolar Pre-RRNA Processing Protein) is a Protein Coding gene. Diseases associated with NIP7 include shwachman-bodian-diamond syndrome. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for NIP7 Gene

  • Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.

Gene Wiki entry for NIP7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIP7 Gene

Genomics for NIP7 Gene

Regulatory Elements for NIP7 Gene

Genomic Location for NIP7 Gene

Start:
69,339,430 bp from pter
End:
69,343,111 bp from pter
Size:
3,682 bases
Orientation:
Plus strand

Genomic View for NIP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIP7 Gene

Proteins for NIP7 Gene

  • Protein details for NIP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y221-NIP7_HUMAN
    Recommended name:
    60S ribosome subunit biogenesis protein NIP7 homolog
    Protein Accession:
    Q9Y221
    Secondary Accessions:
    • B2RD04
    • Q9NZZ0

    Protein attributes for NIP7 Gene

    Size:
    180 amino acids
    Molecular mass:
    20463 Da
    Quaternary structure:
    • Monomer. Interacts with pre-ribosome complex. May bind to RNA (By similarity). Interacts with NOL8. May interact with SBDS. Interacts with FTSJ3.

    Three dimensional structures from OCA and Proteopedia for NIP7 Gene

    Alternative splice isoforms for NIP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NIP7 Gene

Proteomics data for NIP7 Gene at MOPED

Post-translational modifications for NIP7 Gene

  • Ubiquitination at Lys50, Lys94, Lys115, and Lys155
  • Modification sites at PhosphoSitePlus

Other Protein References for NIP7 Gene

No data available for DME Specific Peptides for NIP7 Gene

Domains for NIP7 Gene

Suggested Antigen Peptide Sequences for NIP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y221

UniProtKB/Swiss-Prot:

NIP7_HUMAN :
  • Q9Y221
Domain:
  • Contains 1 PUA domain.
Family:
  • Belongs to the NIP7 family.
genes like me logo Genes that share domains with NIP7: view

No data available for Gene Families for NIP7 Gene

Function for NIP7 Gene

Molecular function for NIP7 Gene

UniProtKB/Swiss-Prot Function: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.

Gene Ontology (GO) - Molecular Function for NIP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 14660641
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NIP7: view

Phenotypes for NIP7 Gene

GenomeRNAi human phenotypes for NIP7:
genes like me logo Genes that share phenotypes with NIP7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NIP7 Gene

Localization for NIP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIP7 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIP7 Gene COMPARTMENTS Subcellular localization image for NIP7 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NIP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with NIP7: view

Pathways for NIP7 Gene

SuperPathways for NIP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042255 ribosome assembly IEA --
genes like me logo Genes that share ontologies with NIP7: view

No data available for Pathways by source for NIP7 Gene

Transcripts for NIP7 Gene

Unigene Clusters for NIP7 Gene

NIP7, nucleolar pre-rRNA processing protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NIP7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for NIP7 Gene

GeneLoc Exon Structure for
NIP7
ECgene alternative splicing isoforms for
NIP7

Expression for NIP7 Gene

mRNA expression in normal human tissues for NIP7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NIP7 Gene

SOURCE GeneReport for Unigene cluster for NIP7 Gene Hs.585728

mRNA Expression by UniProt/SwissProt for NIP7 Gene

Q9Y221-NIP7_HUMAN
Tissue specificity: Expressed in hematopoietic stem/progenitor cells.
genes like me logo Genes that share expressions with NIP7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NIP7 Gene

Orthologs for NIP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NIP7 35
  • 100 (n)
  • 100 (a)
NIP7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NIP7 35
  • 90.74 (n)
  • 98.33 (a)
NIP7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIP7 35
  • 91.48 (n)
  • 96.11 (a)
NIP7 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nip7 35
  • 87.04 (n)
  • 97.78 (a)
Nip7 16
Nip7 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NIP7 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIP7 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nip7 35
  • 88.15 (n)
  • 97.22 (a)
chicken
(Gallus gallus)
Aves NIP7 35
  • 77.96 (n)
  • 85.56 (a)
NIP7 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIP7 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nip7 35
  • 77.41 (n)
  • 90 (a)
Str.10336 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6718 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16108 35
nip7 35
  • 73.52 (n)
  • 82.22 (a)
nip7 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002330 35
  • 64.43 (n)
  • 67.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7006 35
  • 63.5 (n)
  • 64.8 (a)
CG7006 36
  • 64 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C43E11.9 35
  • 59.22 (n)
  • 61.45 (a)
C43E11.9 36
  • 61 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL104W 35
  • 60.15 (n)
  • 59.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP7 35
  • 56.98 (n)
  • 56.98 (a)
NIP7 36
  • 56 (a)
OneToOne
NIP7 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02266g 35
  • 59.22 (n)
  • 59.78 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.383 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G15770 35
  • 61.64 (n)
  • 62.01 (a)
rice
(Oryza sativa)
Liliopsida Os07g0670600 35
  • 55.87 (n)
  • 55.87 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00105 35
  • 53.45 (n)
  • 53.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC320.11c 35
  • 64.06 (n)
  • 64.25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6681 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5575 36
  • 74 (a)
OneToOne
Species with no ortholog for NIP7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIP7 Gene

ENSEMBL:
Gene Tree for NIP7 (if available)
TreeFam:
Gene Tree for NIP7 (if available)

Paralogs for NIP7 Gene

Pseudogenes.org Pseudogenes for NIP7 Gene

genes like me logo Genes that share paralogs with NIP7: view

No data available for Paralogs for NIP7 Gene

Variants for NIP7 Gene

Sequence variations from dbSNP and Humsavar for NIP7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs8053850 -- 69,341,755(+) CTCTG(A/G)CCTCT utr-variant-3-prime
rs8053896 -- 69,341,938(+) GGAAC(C/T)AGGAA utr-variant-3-prime
rs11540992 -- 69,342,366(+) AAGGC(A/G)GACGG utr-variant-3-prime
rs58641063 -- 69,342,247(+) TGAAA(A/G)TCAGC utr-variant-3-prime
rs72795286 -- 69,342,010(+) TATTA(A/G)TATGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NIP7 Gene

Variant ID Type Subtype PubMed ID
nsv906820 CNV Loss 21882294
nsv827715 CNV Loss 20364138

Relevant External Links for NIP7 Gene

HapMap Linkage Disequilibrium report
NIP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIP7 Gene

Disorders for NIP7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NIP7 Gene including...

Search for NIP7 Gene in MalaCards »
genes like me logo Genes that share disorders with NIP7: view

No data available for UniProtKB/Swiss-Prot for NIP7 Gene

Publications for NIP7 Gene

  1. Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells. (PMID: 15522784) Liu J.-F. … Liang D.-C. (J. Struct. Biol. 2004) 3 4 23
  2. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PMID: 14660641) Sekiguchi T. … Nishimoto T. (J. Biol. Chem. 2004) 2 3 4
  3. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. (PMID: 22195017) Morello L.G. … Zanchin N.I. (PLoS ONE 2011) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NIP7 Gene

Sources for NIP7 Gene

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