Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NINL Gene

Aliases for NINL Gene

  • Ninein Like 2 3 5
  • NLP 3 4
  • Ninein-Like Protein 2
  • KIAA0980 4

External Ids for NINL Gene

Previous GeneCards Identifiers for NINL Gene

  • GC20M025383

Summaries for NINL Gene

GeneCards Summary for NINL Gene

NINL (Ninein Like) is a Protein Coding gene. Diseases associated with NINL include leber congenital amaurosis. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NIN.

UniProtKB/Swiss-Prot for NINL Gene

  • Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.

Gene Wiki entry for NINL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NINL Gene

Genomics for NINL Gene

Regulatory Elements for NINL Gene

Promoters for NINL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NINL on UCSC Golden Path with GeneCards custom track

Genomic Location for NINL Gene

Chromosome:
20
Start:
25,452,697 bp from pter
End:
25,585,531 bp from pter
Size:
132,835 bases
Orientation:
Minus strand

Genomic View for NINL Gene

Genes around NINL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NINL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NINL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NINL Gene

Proteins for NINL Gene

  • Protein details for NINL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2I6-NINL_HUMAN
    Recommended name:
    Ninein-like protein
    Protein Accession:
    Q9Y2I6
    Secondary Accessions:
    • A6NJN0
    • B3V9H6
    • B7Z1V8
    • Q5JYP0
    • Q8NE38
    • Q9NQE3

    Protein attributes for NINL Gene

    Size:
    1382 amino acids
    Molecular mass:
    156344 Da
    Quaternary structure:
    • Interacts with gamma-tubulin and TUBGCP4. Interacts with anaphase promoting complex/cyclosome (APC/C). Interacts with CDC20 and FZR1. Isoform 2 interacts with LCA5 and USH2A.
    SequenceCaution:
    • Sequence=BAA76824.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAH11644.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH11644.1; Type=Erroneous termination; Positions=405; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for NINL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NINL Gene

Proteomics data for NINL Gene at MOPED

Post-translational modifications for NINL Gene

  • Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin.
  • Ubiquitinated by the APC/C complex leading to its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NINL Gene

No data available for DME Specific Peptides for NINL Gene

Domains & Families for NINL Gene

Gene Families for NINL Gene

Protein Domains for NINL Gene

Suggested Antigen Peptide Sequences for NINL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2I6

UniProtKB/Swiss-Prot:

NINL_HUMAN :
  • The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C pathway.
Domain:
  • The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C pathway.
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with NINL: view

Function for NINL Gene

Molecular function for NINL Gene

UniProtKB/Swiss-Prot Function:
Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.
genes like me logo Genes that share phenotypes with NINL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NINL

CRISPR Products

miRNA for NINL Gene

miRTarBase miRNAs that target NINL

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NINL Gene

Localization for NINL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NINL Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex (PubMed:16254247). During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm (PubMed:16254247).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NINL Gene COMPARTMENTS Subcellular localization image for NINL gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for NINL Gene

Pathways & Interactions for NINL Gene

genes like me logo Genes that share pathways with NINL: view

Pathways by source for NINL Gene

SIGNOR curated interactions for NINL Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NINL Gene

None

Drugs & Compounds for NINL Gene

No Compound Related Data Available

Transcripts for NINL Gene

Unigene Clusters for NINL Gene

Ninein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NINL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: - -
SP8: -
SP9:
SP10: -
SP11:
SP12:
SP13: -

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for NINL Gene

GeneLoc Exon Structure for
NINL
ECgene alternative splicing isoforms for
NINL

Expression for NINL Gene

mRNA expression in normal human tissues for NINL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NINL Gene

This gene is overexpressed in Monocytes (33.8), CD4 Tcells (12.2), Blymphocyte (9.1), and Fetal ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NINL Gene



SOURCE GeneReport for Unigene cluster for NINL Gene Hs.631508

mRNA Expression by UniProt/SwissProt for NINL Gene

Q9Y2I6-NINL_HUMAN
Tissue specificity: Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina.
genes like me logo Genes that share expression patterns with NINL: view

Protein tissue co-expression partners for NINL Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NINL Gene

Orthologs for NINL Gene

This gene was present in the common ancestor of animals.

Orthologs for NINL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100297905 35
  • 78.77 (n)
  • 70.8 (a)
-- 36
  • 53 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NINL 35
  • 78.96 (n)
  • 71.31 (a)
NINL 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ninl 35
  • 72.47 (n)
  • 63.55 (a)
Ninl 16
Ninl 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NINL 35
  • 99.13 (n)
  • 98.48 (a)
NINL 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ninl 35
  • 72.69 (n)
  • 63.9 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves NINL 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NINL 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ninl 35
  • 62.96 (n)
  • 58.66 (a)
zebrafish
(Danio rerio)
Actinopterygii ninl 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bsg25D 36
  • 16 (a)
OneToMany
Species with no ortholog for NINL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NINL Gene

ENSEMBL:
Gene Tree for NINL (if available)
TreeFam:
Gene Tree for NINL (if available)

Paralogs for NINL Gene

Paralogs for NINL Gene

genes like me logo Genes that share paralogs with NINL: view

Variants for NINL Gene

Sequence variations from dbSNP and Humsavar for NINL Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6115193 - 25,476,386(+) TCCCC(C/T)GCACG intron-variant, reference, missense
rs17857107 - 25,453,503(+) GAGCG(A/C/G/T)GAACT reference, missense
rs6115203 - 25,517,794(+) GAACA(A/C)CAGCA reference, missense
rs34585177 - 25,505,023(-) TGCAG(C/G)CCCTC reference, missense
rs13044759 - 25,503,987(+) AACCC(A/G)AGTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NINL Gene

Variant ID Type Subtype PubMed ID
nsv522873 CNV Gain 19592680
dgv4560n71 CNV Gain 21882294
nsv178907 CNV Loss 16902084
esv2722329 CNV Deletion 23290073
dgv699e201 CNV Deletion 23290073
esv2668672 CNV Deletion 23128226
nsv3341 CNV Insertion 18451855
nsv499328 CNV Gain 21111241
dgv4561n71 CNV Gain 21882294
esv29455 CNV Loss 19812545
esv2722330 CNV Deletion 23290073

Variation tolerance for NINL Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.00; 80.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NINL Gene

HapMap Linkage Disequilibrium report
NINL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NINL Gene

Disorders for NINL Gene

MalaCards: The human disease database

(1) MalaCards diseases for NINL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leber congenital amaurosis
  • lca
- elite association - COSMIC cancer census association via MalaCards
Search NINL in MalaCards View complete list of genes associated with diseases

Relevant External Links for NINL

Genetic Association Database (GAD)
NINL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NINL
genes like me logo Genes that share disorders with NINL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NINL Gene

Publications for NINL Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3

Products for NINL Gene

Sources for NINL Gene

Back to Top

Content