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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NINL Gene

protein-coding   GIFtS: 50
GCID: GC20M025383

Ninein-Like

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ninein-like1 2
Ninein-Like Protein1 2
NLP2 3
dJ691N24.12
KIAA09803

External Ids:    HGNC: 291631   Entrez Gene: 229812   Ensembl: ENSG000001010047   OMIM: 6095805   UniProtKB: Q9Y2I63   

Export aliases for NINL gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NINL Gene: 
NINL (ninein-like) is a protein-coding gene. Diseases associated with NINL include usher syndrome, and leber congenital amaurosis, and among its related super-pathways are G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NIN.

UniProtKB/Swiss-Prot: NINL_HUMAN, Q9Y2I6
Function: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation
of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle
assembly. May play a role in ovarian carcinogenesis

Gene Wiki entry for NINL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NINL gene promoter:
         ER-alpha   Sp1   FOXF2   Nkx2-5   Tal-1beta   NF-E2 p45   Egr-4   HFH-1   ITF-2   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NINL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NINL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.22-p11.1   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.22-p11.1

NINL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NINL gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M025383:  view genomic region     (about GC identifiers)

Start:
25,433,337 bp from pter      End:
25,566,153 bp from pter
Size:
132,817 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NINL_HUMAN, Q9Y2I6 (See protein sequence)
Recommended Name: Ninein-like protein  
Size: 1382 amino acids; 156344 Da
Subunit: Interacts with gamma-tubulin and TUBGCP4. Interacts with anaphase promoting complex/cyclosome (APC/C).
Interacts with CDC20 and FZR1. Isoform 2 interacts with LCA5 and USH2A
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In
interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex. During centrosome
maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm
Sequence caution: Sequence=BAA76824.1; Type=Erroneous initiation; Sequence=BAH11644.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAH11644.1; Type=Erroneous termination; Positions=405;
Note=Translated as Gln;
Secondary accessions: A6NJN0 B3V9H6 B7Z1V8 Q5JYP0 Q8NE38 Q9NQE3
Alternative splicing: 2 isoforms:  Q9Y2I6-1   Q9Y2I6-2   

Explore the universe of human proteins at neXtProt for NINL: NX_Q9Y2I6

Explore proteomics data for NINL at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin
  • UniProtKB: Ubiquitinated by the APC/C complex leading to its degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2I6

  • NINL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NINL Protein Expression
    REFSEQ proteins: NP_079452.3  
    ENSEMBL proteins: 
     ENSP00000278886   ENSP00000338621   ENSP00000410431  
    Reactome Protein details: Q9Y2I6
    Human Recombinant Protein Products for NINL: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NINL 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--

    NINL for ontologies           About GeneDecksing



    NINL Antibody Products: 
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    Assay Products for NINL: 
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    Cloud-Clone Corp. ELISAs for NINL 
    Cloud-Clone Corp. CLIAs for NINL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9Y2I6

    ProtoNet protein and cluster: Q9Y2I6

    UniProtKB/Swiss-Prot: NINL_HUMAN, Q9Y2I6
    Domain: The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C
    pathway
    Similarity: Contains 4 EF-hand domains


    NINL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NINL_HUMAN, Q9Y2I6
    Function: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation
    of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle
    assembly. May play a role in ovarian carcinogenesis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    NINL for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NINL 
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    hsa-miR-137 hsa-miR-25 hsa-miR-548a-3p hsa-miR-633 hsa-miR-199b-5p hsa-miR-92b hsa-miR-3163 hsa-miR-92a
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NINL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    3PLK1 signaling events
    PLK1 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NINL
        PLK1 signaling events

    5/8        Reactome Pathways for NINL (see all 8)
        Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    G2/M Transition
    Loss of proteins required for interphase microtubule organization,from the centrosome



    NINL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NINL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/119 Interacting proteins for NINL (Q9Y2I62, 3 ENSP000002788864) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APEX2Q9UBZ42, 3, ENSP000003641264MINT-67835 I2D: score=5 STRING: ENSP00000364126
    GPKOWQ929172, 3, ENSP000001561094MINT-66821 I2D: score=5 STRING: ENSP00000156109
    KAT7O952512, 3, ENSP000002590214MINT-67724 I2D: score=5 STRING: ENSP00000259021
    MAD1L1Q9Y6D92, 3, ENSP000003825624MINT-66346 I2D: score=5 STRING: ENSP00000382562
    MBIPQ9NS732, 3, ENSP000003244444MINT-68225 I2D: score=5 STRING: ENSP00000324444
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--

    NINL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NINL

    Search CenterWatch for drugs/clinical trials and news about NINL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NINL gene: 
    NM_025176.4  

    Unigene Cluster for NINL:

    Ninein-like
    Hs.631508  [show with all ESTs]
    Unigene Representative Sequence: NM_025176
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278886(uc002wux.1) ENST00000464285(uc002wuw.1) ENST00000496509
    ENST00000336104 ENST00000489780 ENST00000461642 ENST00000422516(uc010ztf.1 uc010gdn.1 uc010gdo.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-137 hsa-miR-25 hsa-miR-548a-3p hsa-miR-633 hsa-miR-199b-5p hsa-miR-92b hsa-miR-3163 hsa-miR-92a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NINL
    Clone
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    OriGene ORF clones in mouse, rat for NINL
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NINL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NINL
    Sirion Biotech Customized lentivirus for stable overexpression of NINL 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NINL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NINL

    Additional mRNA sequence: 

    AB023197.1 AK021854.1 AK093569.1 AK293991.1 AK309298.1 BC036380.2 BC113094.1 EU718622.1 

    12 DOTS entries:

    DT.112811  DT.100023470  DT.100749001  DT.91751570  DT.95366673  DT.91797802  DT.40229147  DT.40301667 
    DT.91719162  DT.91847552  DT.97779713  DT.97807014 

    24/130 AceView cDNA sequences (see all 130):

    BE549664 W63779 BM272814 AI937939 AI024623 BF433031 BQ716730 BQ006249 
    AA932529 AV703170 BU501093 AI687455 AA610759 AB023197 BI914911 BE670018 
    AI126974 AL134587 BP352100 AA205072 AA148761 AI631012 BU687429 AA890134 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NINL (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:        -     -                                                                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:              -                                                                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
    SP1:                                                      
    SP2:  -                                                   
    SP3:                          -                           
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for NINL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NINL expression in normal human tissues (normalized intensities)      NINL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTGCTTCC
    NINL Expression
    About this image


    NINL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             superior temporal gyrus   
     
     Thymus (Hematopoietic System)
             Double Negative 3 Thymocytes Thymus
     
     Breast (Uncategorized)
             breast epithelium   
     
     Blood (Cardiovascular System)
             Double Negative 3 Thymocytes Thymus
     
     Epithelium
             breast epithelium   

    See NINL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NINL

    SOURCE GeneReport for Unigene cluster: Hs.631508

    UniProtKB/Swiss-Prot: NINL_HUMAN, Q9Y2I6
    Tissue specificity: Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma
    cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level).
    Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NINL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NINL gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ninl1 , 5 ninein-like1, 5 72.67(n)1
    63.93(a)1
      2 (74.76 cM)5
    781771  NM_207204.21  NP_997087.21 
     1509345195 
    chicken
    (Gallus gallus)
    Aves NINL6
    ninein-like
    22(a)
    1 ↔ 1
    3(15748107-15762238)
    lizard
    (Anolis carolinensis)
    Reptilia NINL6
    Uncharacterized protein
    36(a)
    1 ↔ 1
    1(254246286-254286376)
    zebrafish
    (Danio rerio)
    Actinopterygii NINL6
    ninein-like
    43(a)
    1 ↔ 1
    13(6999808-7026723)
    fruit fly
    (Drosophila melanogaster)
    Insecta Bsg25D6
    Blastoderm-specific gene 25D
    12(a)
    1 → many
    2L(5271728-5278558)
    worm
    (Caenorhabditis elegans)
    Secernentea T04F8.66
    Protein T04F8.6
    14(a)
    1 → many
    X(11667158-11672269)


    ENSEMBL Gene Tree for NINL (if available)
    TreeFam Gene Tree for NINL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NINL gene
    NIN2  

    NINL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3201 SNPs in NINL are shown (see all 3201)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019068261,2
    Cuntested125459729(+) AGGTCA/GGCCTT 2 A syn10--------
    rs1908366671,2
    --25432880(+) AGAGTC/TTTCCT 1 -- ds50010--------
    rs1839613381,2
    --25433007(+) ATCAGG/TAAACT 1 -- ds50010--------
    rs1128282451,2
    C--25433015(-) TTCTTC/TAAAGT 1 -- ds50010--------
    rs1875991511,2
    --25433249(+) TGATGC/GGCACA 1 -- ds50010--------
    rs1922214211,2
    --25433306(+) ATAGTA/TTAAAA 1 -- ds50010--------
    rs28561,2
    C,F,A,H--25433536(+) ATCATC/TCCTGA 1 -- ut31 ese332Minor allele frequency- T:0.42MN NS EA NA WA CSA 2864
    rs1444398281,2
    --25433560(+) GTCCCC/TGGAGA 1 -- ut310--------
    rs1392429011,2
    C--25433561(+) TCCCCA/GGAGAA 1 -- ut310--------
    rs1843292271,2
    --25433647(+) TCCACC/TAAGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NINL (25433337 - 25566153 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for NINL (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668672CNV Deletion23128226
    esv2722330CNV Deletion23290073
    esv2722329CNV Deletion23290073
    dgv699e201CNV Deletion23290073
    nsv3341CNV Insertion18451855
    esv29455CNV Loss19812545
    nsv178907CNV Loss16902084
    nsv522873CNV Gain19592680
    dgv4560n71CNV Gain21882294
    dgv4561n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609580    OMIM disorders: --

    7 diseases for NINL:    About MalaCards
    usher syndrome    leber congenital amaurosis    osteosarcoma    esophagitis
    cervicitis    ovarian cancer    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for NINL:
    Usher syndrome

    NINL for disorders           About GeneDecksing

    Genetic Association Database (GAD): NINL

    Export disorders for NINL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NINL gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with NINL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Usher syndrome and Leber congenital amaurosis are molecularly linked via a novel isoform of the centrosomal ninein-like protein. (PubMed id 18826961)1, 2 van Wijk E.... Kremer H. (2009)
    3. Increased expression of Nlp, a potential oncogene in ovarian cancer, and its implication in carcinogenesis. (PubMed id 18538832)1, 2 Qu D.... Zhan Q. (2008)
    4. Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex. (PubMed id 17403670)1, 2 Wang Y. and Zhan Q. (2007)
    5. Phosphorylation of Nlp by Plk1 negatively regulates its dynein- dynactin-dependent targeting to the centrosome. (PubMed id 16254247)1, 2 Casenghi M.... Nigg E.A. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. (PubMed id 12852856)1, 2 Casenghi M....Nigg E.A. (2003)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    10. Overexpression of centrosomal protein Nlp confers brea st carcinoma resistance to paclitaxel. (PubMed id 22353935)1 Zhao W....Zhan Q. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22981 HGNC: 29163 AceView: KIAA0980 Ensembl:ENSG00000101004 euGenes: HUgn22981
    ECgene: NINL H-InvDB: NINL

    (According to HUGE)
    About This Section
    HUGE: KIAA0980

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NINL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NINL gene:
    Search GeneIP for patents involving NINL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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