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NINL Gene

protein-coding   GIFtS: 53
GCID: GC20M025383

Ninein-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ninein-like1 2
Ninein-Like Protein1 2
NLP2 3
dJ691N24.12
KIAA09803

External Ids:    HGNC: 291631   Entrez Gene: 229812   Ensembl: ENSG000001010047   OMIM: 6095805   UniProtKB: Q9Y2I63   

Export aliases for NINL gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NINL Gene:
NINL (ninein-like) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NIN.

UniProtKB/Swiss-Prot: NINL_HUMAN, Q9Y2I6
Function: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation
of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle
assembly. May play a role in ovarian carcinogenesis

Gene Wiki entry for NINL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NINL gene promoter:
         ER-alpha   Sp1   FOXF2   Nkx2-5   Tal-1beta   NF-E2 p45   Egr-4   HFH-1   ITF-2   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NINL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NINL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.22-p11.1   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p11.22-p11.1

NINL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NINL gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M025383:  view genomic region     (about GC identifiers)

Start:
25,433,337 bp from pter      End:
25,566,153 bp from pter
Size:
132,817 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NINL_HUMAN, Q9Y2I6 (See protein sequence)
Recommended Name: Ninein-like protein  
Size: 1382 amino acids; 156344 Da
Subunit: Interacts with gamma-tubulin and TUBGCP4. Interacts with anaphase promoting complex/cyclosome (APC/C).
Interacts with CDC20 and FZR1. Isoform 2 interacts with LCA5 and USH2A
Sequence caution: Sequence=BAA76824.1; Type=Erroneous initiation; Sequence=BAH11644.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAH11644.1; Type=Erroneous termination; Positions=405;
Note=Translated as Gln;
Secondary accessions: A6NJN0 B3V9H6 B7Z1V8 Q5JYP0 Q8NE38 Q9NQE3
Alternative splicing: 2 isoforms:  Q9Y2I6-1   Q9Y2I6-2   

Explore the universe of human proteins at neXtProt for NINL: NX_Q9Y2I6

Explore proteomics data for NINL at MOPED

Post-translational modifications: 

  • Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin1
  • Ubiquitinated by the APC/C complex leading to its degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NINL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079452.3  
    ENSEMBL proteins: 
     ENSP00000278886   ENSP00000338621   ENSP00000410431  
    Reactome Protein details: Q9Y2I6

    NINL Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NINL

     
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    Search antibodies-online for proteins for NINL 

     
    Search antibodies-online for peptides for NINL

    NINL Antibody Products:

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    antibodies-online antibodies for NINL 

    NINL Assay Products:

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    Cloud-Clone Corp. ELISAs for NINL
    Cloud-Clone Corp. CLIAs for NINL
    Search eBioscience for ELISAs for NINL 
    antibodies-online kits for NINL (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9Y2I6

    ProtoNet protein and cluster: Q9Y2I6

    UniProtKB/Swiss-Prot: NINL_HUMAN, Q9Y2I6
    Domain: The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C
    pathway
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with NINL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NINL_HUMAN, Q9Y2I6
    Function: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation
    of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle
    assembly. May play a role in ovarian carcinogenesis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with NINL           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NINL

    miRNA
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    miRTarBase miRNAs that target NINL:
    hsa-mir-335-5p (MIRT018701)

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    Selected qRT-PCR Assays for microRNAs that regulate NINL (see all 17):
    hsa-miR-137 hsa-miR-25 hsa-miR-548a-3p hsa-miR-633 hsa-miR-199b-5p hsa-miR-92b hsa-miR-3163 hsa-miR-92a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: NINL (NM_025176)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NINL

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NINL_HUMAN, Q9Y2I6: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In
    interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex. During centrosome
    maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with NINL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NINL About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3PLK1 signaling events
    PLK1 signaling events


    Find genes that share SuperPaths with NINL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NINL
        PLK1 signaling events

    4 Reactome Pathways for NINL
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Loss of Nlp from mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NINL
    Interactions:

        Search GeneGlobe Interaction Network for NINL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NINL (Q9Y2I62, 3 ENSP000002788864) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APEX2Q9UBZ42, 3, ENSP000003641264MINT-67835 I2D: score=5 STRING: ENSP00000364126
    GPKOWQ929172, 3, ENSP000001561094MINT-66821 I2D: score=5 STRING: ENSP00000156109
    KAT7O952512, 3, ENSP000002590214MINT-67724 I2D: score=5 STRING: ENSP00000259021
    MAD1L1Q9Y6D92, 3, ENSP000003825624MINT-66346 I2D: score=5 STRING: ENSP00000382562
    MBIPQ9NS732, 3, ENSP000003244444MINT-68225 I2D: score=5 STRING: ENSP00000324444
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--

    Find genes that share ontologies with NINL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NINL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NINL gene: 
    NM_025176.4  

    Unigene Cluster for NINL:

    Ninein-like
    Hs.631508  [show with all ESTs]
    Unigene Representative Sequence: NM_025176
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278886(uc002wux.1) ENST00000464285(uc002wuw.1) ENST00000496509
    ENST00000336104 ENST00000489780 ENST00000461642 ENST00000422516(uc010ztf.1 uc010gdn.1 uc010gdo.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NINL (see all 17):
    hsa-miR-137 hsa-miR-25 hsa-miR-548a-3p hsa-miR-633 hsa-miR-199b-5p hsa-miR-92b hsa-miR-3163 hsa-miR-92a
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NINL
      QuantiTect SYBR Green Assays in human, mouse, rat NINL
      QuantiFast Probe-based Assays in human, mouse, rat NINL

    Additional mRNA sequence: 

    AB023197.1 AK021854.1 AK093569.1 AK293991.1 AK309298.1 BC036380.2 BC113094.1 EU718622.1 

    12 DOTS entries:

    DT.112811  DT.100023470  DT.100749001  DT.91751570  DT.95366673  DT.91797802  DT.40229147  DT.40301667 
    DT.91719162  DT.91847552  DT.97779713  DT.97807014 

    Selected AceView cDNA sequences (see all 130):

    BM875349 AA205072 BM272814 BE670018 BU687429 BE549664 AA890134 D31019 
    AA148595 BQ006249 W63779 BF433031 BP352100 AI937939 AW136791 AL134587 
    AB023197 BI914911 AI126974 AV705052 AI024623 AI631012 AA148761 BQ716730 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NINL (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:        -     -                                                                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:              -                                                                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
    SP1:                                                      
    SP2:  -                                                   
    SP3:                          -                           
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for NINL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NINL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTGCTTCC
    NINL Expression
    About this image


    NINL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 3 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 3 Thymocytes Thymus
    NINL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NINL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631508

    UniProtKB/Swiss-Prot: NINL_HUMAN, Q9Y2I6
    Tissue specificity: Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma
    cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level).
    Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NINL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for NINL gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ninl1 , 5 ninein-like1, 5 72.47(n)1
    63.55(a)1
      2 (74.76 cM)5
    781771  NM_207204.21  NP_997087.21 
     1509345195 
    chicken
    (Gallus gallus)
    Aves NINL6
    ninein-like
    29(a)
    1 ↔ 1
    3(15748107-15762238)
    lizard
    (Anolis carolinensis)
    Reptilia NINL6
    ninein-like
    36(a)
    1 ↔ 1
    1(254246286-254286376)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ninl1 ninein-like 62.96(n)
    58.66(a)
      100124705  NM_001102691.1  NP_001096161.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ninl6
    ninein-like
    45(a)
    1 ↔ 1
    13(6999808-7026723) ENSDARG00000075119
    fruit fly
    (Drosophila melanogaster)
    Insecta Bsg25D6
    Blastoderm-specific gene 25D
    16(a)
    1 → many
    2L(5271728-5278558)


    ENSEMBL Gene Tree for NINL (if available)
    TreeFam Gene Tree for NINL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NINL gene
    NIN2  

    Find genes that share paralogs with NINL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NINL (see all 3201)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019068261,2
    Cuntested125459729(+) AGGTCA/GGCCTT 2 A syn10--------
    rs1908366671,2
    --25432880(+) AGAGTC/TTTCCT 1 -- ds50010--------
    rs1839613381,2
    --25433007(+) ATCAGG/TAAACT 1 -- ds50010--------
    rs1128282451,2
    C--25433015(-) TTCTTC/TAAAGT 1 -- ds50010--------
    rs1875991511,2
    --25433249(+) TGATGC/GGCACA 1 -- ds50010--------
    rs1922214211,2
    --25433306(+) ATAGTA/TTAAAA 1 -- ds50010--------
    rs28561,2
    C,F,A,H--25433536(+) ATCATC/TCCTGA 1 -- ut31 ese332Minor allele frequency- T:0.42MN NS EA NA WA CSA 2864
    rs1444398281,2
    --25433560(+) GTCCCC/TGGAGA 1 -- ut310--------
    rs1392429011,2
    C--25433561(+) TCCCCA/GGAGAA 1 -- ut310--------
    rs1843292271,2
    --25433647(+) TCCACC/TAAGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NINL (25433337 - 25566153 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NINL (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668672CNV Deletion23128226
    esv2722330CNV Deletion23290073
    esv2722329CNV Deletion23290073
    dgv699e201CNV Deletion23290073
    nsv3341CNV Insertion18451855
    esv29455CNV Loss19812545
    nsv178907CNV Loss16902084
    nsv522873CNV Gain19592680
    dgv4560n71CNV Gain21882294
    dgv4561n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NINL
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609580    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NINL:
    Usher syndrome

    Find genes that share disorders with NINL           About GenesLikeMe

    Genetic Association Database (GAD): NINL

    Export disorders for NINL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NINL gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with NINL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Usher syndrome and Leber congenital amaurosis are molecularly linked via a novel isoform of the centrosomal ninein-like protein. (PubMed id 18826961)1, 2 van Wijk E.... Kremer H. (Hum. Mol. Genet. 2009)
    3. Increased expression of Nlp, a potential oncogene in ovarian cancer, and its implication in carcinogenesis. (PubMed id 18538832)1, 2 Qu D.... Zhan Q. (Gynecol. Oncol. 2008)
    4. Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex. (PubMed id 17403670)1, 2 Wang Y. and Zhan Q. (J. Biol. Chem. 2007)
    5. Phosphorylation of Nlp by Plk1 negatively regulates its dynein- dynactin-dependent targeting to the centrosome. (PubMed id 16254247)1, 2 Casenghi M.... Nigg E.A. (J. Cell Sci. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. (PubMed id 12852856)1, 2 Casenghi M....Nigg E.A. (Dev. Cell 2003)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22981 HGNC: 29163 AceView: KIAA0980 Ensembl:ENSG00000101004 euGenes: HUgn22981
    ECgene: NINL H-InvDB: NINL

    (According to HUGE)
    About This Section

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    HUGE: KIAA0980

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NINL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NINL gene:
    Search GeneIP for patents involving NINL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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