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Aliases for NINL Gene

Aliases for NINL Gene

  • Ninein-Like 2 3
  • Ninein-Like Protein 2 3
  • NLP 3 4
  • DJ691N24.1 3
  • KIAA0980 4

External Ids for NINL Gene

Summaries for NINL Gene

GeneCards Summary for NINL Gene

NINL (Ninein-Like) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NIN.

UniProtKB/Swiss-Prot for NINL Gene

  • Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.

Gene Wiki entry for NINL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NINL Gene

Genomics for NINL Gene

Regulatory Elements for NINL Gene

Genomic Location for NINL Gene

Start:
25,452,697 bp from pter
End:
25,585,531 bp from pter
Size:
132,835 bases
Orientation:
Minus strand

Genomic View for NINL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NINL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NINL Gene

Proteins for NINL Gene

  • Protein details for NINL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2I6-NINL_HUMAN
    Recommended name:
    Ninein-like protein
    Protein Accession:
    Q9Y2I6
    Secondary Accessions:
    • A6NJN0
    • B3V9H6
    • B7Z1V8
    • Q5JYP0
    • Q8NE38
    • Q9NQE3

    Protein attributes for NINL Gene

    Size:
    1382 amino acids
    Molecular mass:
    156344 Da
    Quaternary structure:
    • Interacts with gamma-tubulin and TUBGCP4. Interacts with anaphase promoting complex/cyclosome (APC/C). Interacts with CDC20 and FZR1. Isoform 2 interacts with LCA5 and USH2A.
    SequenceCaution:
    • Sequence=BAA76824.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAH11644.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH11644.1; Type=Erroneous termination; Positions=405; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for NINL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NINL Gene

Proteomics data for NINL Gene at MOPED

Post-translational modifications for NINL Gene

  • Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin.
  • Ubiquitinated by the APC/C complex leading to its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NINL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NINL Gene

Domains for NINL Gene

Gene Families for NINL Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for NINL Gene

Suggested Antigen Peptide Sequences for NINL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2I6

UniProtKB/Swiss-Prot:

NINL_HUMAN :
  • Q9Y2I6
Domain:
  • The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C pathway.
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with NINL: view

Function for NINL Gene

Molecular function for NINL Gene

UniProtKB/Swiss-Prot Function: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.

Gene Ontology (GO) - Molecular Function for NINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NINL: view

miRNA for NINL Gene

miRTarBase miRNAs that target NINL

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NINL Gene

Localization for NINL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NINL Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex. During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NINL Gene COMPARTMENTS Subcellular localization image for NINL gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for NINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with NINL: view

Pathways for NINL Gene

genes like me logo Genes that share pathways with NINL: view

Gene Ontology (GO) - Biological Process for NINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with NINL: view

Transcripts for NINL Gene

Unigene Clusters for NINL Gene

Ninein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NINL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: - -
SP8: -
SP9:
SP10: -
SP11:
SP12:
SP13: -

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for NINL Gene

GeneLoc Exon Structure for
NINL
ECgene alternative splicing isoforms for
NINL

Expression for NINL Gene

mRNA expression in normal human tissues for NINL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NINL Gene

SOURCE GeneReport for Unigene cluster for NINL Gene Hs.631508

mRNA Expression by UniProt/SwissProt for NINL Gene

Q9Y2I6-NINL_HUMAN
Tissue specificity: Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina.
genes like me logo Genes that share expressions with NINL: view

No data available for mRNA differential expression in normal tissues for NINL Gene

Orthologs for NINL Gene

This gene was present in the common ancestor of animals.

Orthologs for NINL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NINL 35
  • 99.13 (n)
  • 98.48 (a)
NINL 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 53 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
LOC100297905 35
  • 78.77 (n)
  • 70.8 (a)
dog
(Canis familiaris)
Mammalia NINL 35
  • 78.96 (n)
  • 71.31 (a)
NINL 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ninl 35
  • 72.47 (n)
  • 63.55 (a)
Ninl 16
Ninl 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ninl 35
  • 72.69 (n)
  • 63.9 (a)
chicken
(Gallus gallus)
Aves NINL 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NINL 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ninl 35
  • 62.96 (n)
  • 58.66 (a)
zebrafish
(Danio rerio)
Actinopterygii ninl 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bsg25D 36
  • 16 (a)
OneToMany
Species with no ortholog for NINL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NINL Gene

ENSEMBL:
Gene Tree for NINL (if available)
TreeFam:
Gene Tree for NINL (if available)

Paralogs for NINL Gene

Paralogs for NINL Gene

genes like me logo Genes that share paralogs with NINL: view

Variants for NINL Gene

Sequence variations from dbSNP and Humsavar for NINL Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2856 -- 25,452,900(+) ATCAT(C/T)CCTGA utr-variant-3-prime
rs12428 -- 25,453,185(+) TCCAG(A/C)GAGTG utr-variant-3-prime
rs84816 -- 25,479,283(+) AACAC(A/G)AAGCT intron-variant
rs364722 -- 25,480,170(+) GTCTC(C/T)AGCTG synonymous-codon, reference
rs366060 -- 25,506,132(+) tggca(C/G)ccgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NINL Gene

Variant ID Type Subtype PubMed ID
nsv522873 CNV Gain 19592680
dgv4560n71 CNV Gain 21882294
nsv178907 CNV Loss 16902084
esv2722329 CNV Deletion 23290073
dgv699e201 CNV Deletion 23290073
esv2668672 CNV Deletion 23128226
nsv3341 CNV Insertion 18451855
nsv499328 CNV Gain 21111241
dgv4561n71 CNV Gain 21882294
esv29455 CNV Loss 19812545
esv2722330 CNV Deletion 23290073

Relevant External Links for NINL Gene

HapMap Linkage Disequilibrium report
NINL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NINL Gene

Disorders for NINL Gene

(1) University of Copenhagen DISEASES for NINL Gene

Relevant External Links for NINL

Genetic Association Database (GAD)
NINL
genes like me logo Genes that share disorders with NINL: view

No data available for UniProtKB/Swiss-Prot for NINL Gene

Publications for NINL Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. (PMID: 12852856) Casenghi M. … Nigg E.A. (Dev. Cell 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NINL Gene

Sources for NINL Gene

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