Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NINJ2 Gene

Aliases for NINJ2 Gene

  • Ninjurin 2 2 3 5
  • Nerve Injury-Induced Protein 2 4

External Ids for NINJ2 Gene

Previous GeneCards Identifiers for NINJ2 Gene

  • GC12M000526
  • GC12M000543
  • GC12M000673

Summaries for NINJ2 Gene

Entrez Gene Summary for NINJ2 Gene

  • The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]

GeneCards Summary for NINJ2 Gene

NINJ2 (Ninjurin 2) is a Protein Coding gene. An important paralog of this gene is NINJ1.

UniProtKB/Swiss-Prot for NINJ2 Gene

  • Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NINJ2 Gene

Genomics for NINJ2 Gene

Regulatory Elements for NINJ2 Gene

Enhancers for NINJ2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NINJ2 on UCSC Golden Path with GeneCards custom track

Promoters for NINJ2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NINJ2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NINJ2 Gene

564,296 bp from pter
663,779 bp from pter
99,484 bases
Minus strand

Genomic View for NINJ2 Gene

Genes around NINJ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NINJ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NINJ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NINJ2 Gene

Proteins for NINJ2 Gene

  • Protein details for NINJ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for NINJ2 Gene

    142 amino acids
    Molecular mass:
    15680 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH57766.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for NINJ2 Gene

Proteomics data for NINJ2 Gene at MOPED

Post-translational modifications for NINJ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NINJ2 Gene

No data available for DME Specific Peptides for NINJ2 Gene

Domains & Families for NINJ2 Gene

Protein Domains for NINJ2 Gene


Suggested Antigen Peptide Sequences for NINJ2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ninjurin family.
  • Belongs to the ninjurin family.
genes like me logo Genes that share domains with NINJ2: view

No data available for Gene Families for NINJ2 Gene

Function for NINJ2 Gene

Molecular function for NINJ2 Gene

UniProtKB/Swiss-Prot Function:
Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.
UniProtKB/Swiss-Prot Induction:
By nerve injury; in Schwann cells.
genes like me logo Genes that share phenotypes with NINJ2: view

Animal Models for NINJ2 Gene

MGI Knock Outs for NINJ2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NINJ2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NINJ2 Gene

Localization for NINJ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NINJ2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NINJ2 Gene COMPARTMENTS Subcellular localization image for NINJ2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NINJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NINJ2: view

Pathways & Interactions for NINJ2 Gene

SuperPathways for NINJ2 Gene

No Data Available

Interacting Proteins for NINJ2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000307552 Q9NZG7-NINJ2_HUMAN for NINJ2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for NINJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007399 nervous system development TAS 10627596
genes like me logo Genes that share ontologies with NINJ2: view

No data available for Pathways by source and SIGNOR curated interactions for NINJ2 Gene

Drugs & Compounds for NINJ2 Gene

No Compound Related Data Available

Transcripts for NINJ2 Gene

Unigene Clusters for NINJ2 Gene

Ninjurin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NINJ2 Gene

No ASD Table

Relevant External Links for NINJ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NINJ2 Gene

mRNA expression in normal human tissues for NINJ2 Gene

mRNA differential expression in normal tissues according to GTEx for NINJ2 Gene

This gene is overexpressed in Whole Blood (x9.3) and Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for NINJ2 Gene

This gene is overexpressed in Frontal cortex (51.3), Spinal cord (7.9), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NINJ2 Gene

SOURCE GeneReport for Unigene cluster for NINJ2 Gene Hs.656450

mRNA Expression by UniProt/SwissProt for NINJ2 Gene

Tissue specificity: Widely expressed. In adult, higher expression in the bone marrow and peripheral blood lymphocytes, medium in the lung, lymph node, thyroid, uterus, thymus, spleen, prostate and skeletal muscle, lower in the liver, placenta, brain, heart and kidney. In embryo, higher expression in the thymus, heart and liver, lower in the spleen, lung, brain and kidney.
genes like me logo Genes that share expression patterns with NINJ2: view

Protein tissue co-expression partners for NINJ2 Gene

Primer Products

Orthologs for NINJ2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NINJ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NINJ2 35
  • 86.45 (n)
  • 83.87 (a)
NINJ2 36
  • 82 (a)
(Mus musculus)
Mammalia Ninj2 35
  • 77 (n)
  • 73.24 (a)
Ninj2 16
Ninj2 36
  • 73 (a)
(Pan troglodytes)
Mammalia NINJ2 35
  • 99.47 (n)
  • 99.47 (a)
NINJ2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ninj2 35
  • 80.99 (n)
  • 81.69 (a)
(Bos Taurus)
Mammalia NINJ2 36
  • 69 (a)
(Monodelphis domestica)
Mammalia NINJ2 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia NINJ2 36
  • 65 (a)
(Gallus gallus)
Aves NINJ2 35
  • 68.26 (n)
  • 65.07 (a)
NINJ2 36
  • 61 (a)
(Anolis carolinensis)
Reptilia NINJ2 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ninj2 35
  • 71.11 (n)
  • 68.33 (a)
(Danio rerio)
Actinopterygii ninj2 35
  • 67.5 (n)
  • 62.5 (a)
ninj2 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11637 36
  • 20 (a)
CG14394 36
  • 33 (a)
NijA 36
  • 18 (a)
Species with no ortholog for NINJ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NINJ2 Gene

Gene Tree for NINJ2 (if available)
Gene Tree for NINJ2 (if available)

Paralogs for NINJ2 Gene

Paralogs for NINJ2 Gene

(1) SIMAP similar genes for NINJ2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NINJ2: view

Variants for NINJ2 Gene

Sequence variations from dbSNP and Humsavar for NINJ2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1975816 -- 601,591(-) ccacc(A/G)cacct intron-variant
rs1975817 -- 601,560(-) tattt(A/T)ttttt intron-variant
rs2018395 -- 579,450(-) tcttc(A/G)tcatg intron-variant
rs2075032 -- 607,972(+) TTCCA(A/G)TGCAA intron-variant
rs7134287 -- 614,493(+) CCCAC(C/G)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NINJ2 Gene

Variant ID Type Subtype PubMed ID
dgv452e1 CNV Complex 17122850
dgv1337n71 CNV Gain 21882294
nsv898569 CNV Gain 21882294
nsv468951 CNV Gain 19166990
nsv470254 CNV Gain 18288195
nsv898572 CNV Gain 21882294
nsv519441 CNV Gain 19592680
esv1606062 CNV Insertion 17803354
nsv527632 CNV Loss 19592680
dgv1338n71 CNV Gain 21882294
esv1113146 CNV Deletion 17803354
esv2745360 CNV Deletion 23290073
esv2249356 CNV Deletion 18987734
esv2745361 CNV Deletion 23290073
esv995402 CNV Deletion 20482838
esv1449891 CNV Deletion 17803354
esv989890 CNV Deletion 20482838
esv2745362 CNV Deletion 23290073
esv2745365 CNV Deletion 23290073
esv29801 CNV Loss 19812545
esv2745366 CNV Deletion 23290073
nsv826173 CNV Loss 20364138
nsv818876 CNV Gain 17921354
dgv174n27 CNV Gain 19166990
nsv898575 CNV Gain 21882294
nsv826174 CNV Gain 20364138

Variation tolerance for NINJ2 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NINJ2 Gene

Disorders for NINJ2 Gene

Relevant External Links for NINJ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NINJ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NINJ2 Gene

Publications for NINJ2 Gene

  1. Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth. (PMID: 10627596) Araki T. … Milbrandt J. (J. Neurosci. 2000) 2 3 4 67
  2. Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study. (PMID: 24664524) Zhu Y. … Hu Y. (J. Thromb. Thrombolysis 2014) 3
  3. Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. (PMID: 24959832) Bis J.C. … Fornage M. (PLoS ONE 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis. (PMID: 22297388) Li B.H. … Li J.C. (J. Neurol. Sci. 2012) 3

Products for NINJ2 Gene

Sources for NINJ2 Gene