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Aliases for NINJ2 Gene

Aliases for NINJ2 Gene

  • Ninjurin 2 2 3
  • Nerve Injury-Induced Protein 2 3 4
  • Ninjurin-2 3

External Ids for NINJ2 Gene

Summaries for NINJ2 Gene

Entrez Gene Summary for NINJ2 Gene

  • The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]

GeneCards Summary for NINJ2 Gene

NINJ2 (Ninjurin 2) is a Protein Coding gene. Diseases associated with NINJ2 include acrocallosal syndrome. An important paralog of this gene is NINJ1.

UniProtKB/Swiss-Prot for NINJ2 Gene

  • Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NINJ2 Gene

Genomics for NINJ2 Gene

Genomic Location for NINJ2 Gene

Start:
564,296 bp from pter
End:
663,779 bp from pter
Size:
99,484 bases
Orientation:
Minus strand

Genomic View for NINJ2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NINJ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NINJ2 Gene

Regulatory Elements for NINJ2 Gene

Proteins for NINJ2 Gene

  • Protein details for NINJ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZG7-NINJ2_HUMAN
    Recommended name:
    Ninjurin-2
    Protein Accession:
    Q9NZG7
    Secondary Accessions:

    Protein attributes for NINJ2 Gene

    Size:
    142 amino acids
    Molecular mass:
    15680 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH57766.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for NINJ2 Gene

Proteomics data for NINJ2 Gene at MOPED

Post-translational modifications for NINJ2 Gene

No Post-translational modifications

Other Protein References for NINJ2 Gene

No data available for DME Specific Peptides for NINJ2 Gene

Domains for NINJ2 Gene

Protein Domains for NINJ2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NINJ2_HUMAN
Family:
  • Belongs to the ninjurin family.:
    • Q9NZG7
genes like me logo Genes that share domains with NINJ2: view

No data available for Gene Families for NINJ2 Gene

Function for NINJ2 Gene

Molecular function for NINJ2 Gene

UniProtKB/Swiss-Prot Function: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues
UniProtKB/Swiss-Prot Induction: By nerve injury; in Schwann cells

Gene Ontology (GO) - Molecular Function for NINJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NINJ2: view
genes like me logo Genes that share phenotypes with NINJ2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NINJ2 Gene

Localization for NINJ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NINJ2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NINJ2 Gene COMPARTMENTS Subcellular localization image for NINJ2 gene
Compartment Confidence
plasma membrane 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NINJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10627596
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NINJ2: view

Pathways for NINJ2 Gene

SuperPathways for NINJ2 Gene

No Data Available

Interacting Proteins for NINJ2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307552%0d%0a9606.ENSP00000302569%0d%0a9606.ENSP00000318883%0d%0a
Selected Interacting proteins: ENSP00000307552 Q9NZG7-NINJ2_HUMAN for NINJ2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for NINJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion --
GO:0007158 neuron cell-cell adhesion TAS 10627596
GO:0007399 nervous system development TAS 10627596
GO:0042246 tissue regeneration IEA --
genes like me logo Genes that share ontologies with NINJ2: view

No data available for Pathways by source for NINJ2 Gene

Transcripts for NINJ2 Gene

Unigene Clusters for NINJ2 Gene

Ninjurin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NINJ2 Gene

No ASD Table

Relevant External Links for NINJ2 Gene

GeneLoc Exon Structure for
NINJ2
ECgene alternative splicing isoforms for
NINJ2

Expression for NINJ2 Gene

mRNA expression in normal human tissues for NINJ2 Gene

mRNA differential expression in normal tissues according to GTEx for NINJ2 Gene

This gene is overexpressed in Whole Blood (9.3) and Brain - Spinal cord (cervical c-1) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NINJ2 Gene

SOURCE GeneReport for Unigene cluster for NINJ2 Gene Hs.656450

mRNA Expression by UniProt/SwissProt for NINJ2 Gene

Q9NZG7-NINJ2_HUMAN
Tissue specificity: Widely expressed. In adult, higher expression in the bone marrow and peripheral blood lymphocytes, medium in the lung, lymph node, thyroid, uterus, thymus, spleen, prostate and skeletal muscle, lower in the liver, placenta, brain, heart and kidney. In embryo, higher expression in the thymus, heart and liver, lower in the spleen, lung, brain and kidney
genes like me logo Genes that share expressions with NINJ2: view

Orthologs for NINJ2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NINJ2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NINJ2 36
  • 99.47 (n)
  • 99.47 (a)
NINJ2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NINJ2 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NINJ2 36
  • 86.45 (n)
  • 83.87 (a)
NINJ2 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ninj2 36
  • 77 (n)
  • 73.24 (a)
Ninj2 16
Ninj2 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NINJ2 37
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NINJ2 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ninj2 36
  • 80.99 (n)
  • 81.69 (a)
chicken
(Gallus gallus)
Aves NINJ2 36
  • 68.26 (n)
  • 65.07 (a)
NINJ2 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NINJ2 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ninj2 36
  • 71.11 (n)
  • 68.33 (a)
zebrafish
(Danio rerio)
Actinopterygii ninj2 36
  • 67.5 (n)
  • 62.5 (a)
ninj2 37
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11637 37
  • 20 (a)
ManyToMany
CG14394 37
  • 33 (a)
ManyToMany
NijA 37
  • 18 (a)
ManyToMany
Species with no ortholog for NINJ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NINJ2 Gene

ENSEMBL:
Gene Tree for NINJ2 (if available)
TreeFam:
Gene Tree for NINJ2 (if available)

Paralogs for NINJ2 Gene

Paralogs for NINJ2 Gene

Selected SIMAP similar genes for NINJ2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NINJ2: view

Variants for NINJ2 Gene

Sequence variations from dbSNP and Humsavar for NINJ2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs134982 -- 652,995(+) CAGTG(A/G)AATGA intron-variant
rs722097 -- 605,676(+) AGCAA(A/G)CAAGC intron-variant
rs740891 -- 566,754(+) CTCAG(C/T)ATACA intron-variant
rs740892 -- 566,950(+) AAGAA(A/T)TTCAG intron-variant
rs740893 -- 567,043(+) TGGGC(C/G)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NINJ2 Gene

Variant ID Type Subtype PubMed ID
dgv452e1 CNV Complex 17122850
dgv1337n71 CNV Gain 21882294
nsv898569 CNV Gain 21882294
nsv468951 CNV Gain 19166990
nsv470254 CNV Gain 18288195
nsv898572 CNV Gain 21882294
nsv519441 CNV Gain 19592680
esv1606062 CNV Insertion 17803354
nsv527632 CNV Loss 19592680
dgv1338n71 CNV Gain 21882294
esv1113146 CNV Deletion 17803354
esv2745360 CNV Deletion 23290073
esv2249356 CNV Deletion 18987734
esv2745361 CNV Deletion 23290073
esv995402 CNV Deletion 20482838
esv1449891 CNV Deletion 17803354
esv989890 CNV Deletion 20482838
esv2745362 CNV Deletion 23290073
esv2745365 CNV Deletion 23290073
esv29801 CNV Loss 19812545
esv2745366 CNV Deletion 23290073
nsv826173 CNV Loss 20364138
nsv818876 CNV Gain 17921354
dgv174n27 CNV Gain 19166990
nsv898575 CNV Gain 21882294
nsv826174 CNV Gain 20364138

Relevant External Links for NINJ2 Gene

HapMap Linkage Disequilibrium report
NINJ2

Disorders for NINJ2 Gene

(1) MalaCards Diseases for NINJ2 Gene

Search for NINJ2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NINJ2 Gene

Relevant External Links for NINJ2

Genetic Association Database (GAD)
NINJ2
Human Genome Epidemiology (HuGE) Navigator
NINJ2
genes like me logo Genes that share disorders with NINJ2: view

No data available for UniProtKB/Swiss-Prot for NINJ2 Gene

Publications for NINJ2 Gene

  1. Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth. (PMID: 10627596) Araki T. … Milbrandt J. (J. Neurosci. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genomewide association studies of stroke. (PMID: 19369658) Ikram M.A. … Wolf P.A. (N. Engl. J. Med. 2009) 3 49
  4. Failure to validate association between 12p13 variants and ischemic stroke. (PMID: 20410525) (N. Engl. J. Med. 2010) 3 49
  5. [Strong association between the NINJ2 gene polymorphism and the susceptibility of stroke in Chinese Han population in Fangshan district]. (PMID: 20957003) Chen K. … Qiu C.C. (Beijing Da Xue Xue Bao 2010) 3

Products for NINJ2 Gene

Sources for NINJ2 Gene

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