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Aliases for NINJ2 Gene

Aliases for NINJ2 Gene

  • Ninjurin 2 2 3 5
  • Nerve Injury-Induced Protein 2 3 4
  • Ninjurin-2 3

External Ids for NINJ2 Gene

Previous GeneCards Identifiers for NINJ2 Gene

  • GC12M000526
  • GC12M000543
  • GC12M000673

Summaries for NINJ2 Gene

Entrez Gene Summary for NINJ2 Gene

  • The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]

GeneCards Summary for NINJ2 Gene

NINJ2 (Ninjurin 2) is a Protein Coding gene. An important paralog of this gene is NINJ1.

UniProtKB/Swiss-Prot for NINJ2 Gene

  • Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NINJ2 Gene

Genomics for NINJ2 Gene

Regulatory Elements for NINJ2 Gene

Enhancers for NINJ2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F000614 1.4 FANTOM5 Ensembl ENCODE 21.1 +44.6 44579 10.4 PKNOX1 ARID4B ZNF48 SLC30A9 ZNF121 ELK1 FOS SP5 MXD4 MIER2 LOC100049716 NINJ2 KDM5A WNK1 LOC105369595 CCDC77 GC12M000616
GH12F000629 0.7 ENCODE 17.7 +31.6 31642 4.4 PKNOX1 MLX WRNIP1 ARID4B SIN3A YY1 ZNF121 CBX5 FOS JUNB LOC100049716 NINJ2 LOC105369595 GC12P000646 PIR35680
GH12F000799 0.2 Ensembl 16.4 -137.5 -137522 3.0 HDAC1 PKNOX1 LEF1 TAL1 ZNF121 GATA2 NCOR1 ADNP SMARCE1 ZNF362 WNK1 NINJ2 RNU4ATAC16P GC12P000887
GH12F000776 0.5 Ensembl 16.1 -112.6 -112622 0.8 ZNF202 SCRT1 ZNF501 ZIC2 ZNF664 ZNF121 GLIS1 NR2F6 MLLT1 ZNF18 NINJ2 LOC100288778 WNK1 ENSG00000250132 ERC1 RAD52 GC12M000775 GC12M000753
GH12F000722 0.6 Ensembl ENCODE 12.7 -59.0 -59049 1.1 HDGF PKNOX1 TEAD4 RELA ZNF366 POLR2A EED ZNF202 MTA2 ZNF670 LOC100288778 WNK1 NINJ2 RNU4ATAC16P LOC105369597
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NINJ2 on UCSC Golden Path with GeneCards custom track

Promoters for NINJ2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001774057 679 601 PKNOX1 MNT KDM1A WT1 TRIM28

Genomic Location for NINJ2 Gene

564,296 bp from pter
663,779 bp from pter
99,484 bases
Minus strand

Genomic View for NINJ2 Gene

Genes around NINJ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NINJ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NINJ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NINJ2 Gene

Proteins for NINJ2 Gene

  • Protein details for NINJ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for NINJ2 Gene

    142 amino acids
    Molecular mass:
    15680 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH57766.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for NINJ2 Gene

Post-translational modifications for NINJ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NINJ2 Gene

No data available for DME Specific Peptides for NINJ2 Gene

Domains & Families for NINJ2 Gene

Protein Domains for NINJ2 Gene


Suggested Antigen Peptide Sequences for NINJ2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ninjurin family.
  • Belongs to the ninjurin family.
genes like me logo Genes that share domains with NINJ2: view

No data available for Gene Families for NINJ2 Gene

Function for NINJ2 Gene

Molecular function for NINJ2 Gene

UniProtKB/Swiss-Prot Function:
Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.
UniProtKB/Swiss-Prot Induction:
By nerve injury; in Schwann cells.

Gene Ontology (GO) - Molecular Function for NINJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NINJ2: view
genes like me logo Genes that share phenotypes with NINJ2: view

Animal Models for NINJ2 Gene

MGI Knock Outs for NINJ2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NINJ2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NINJ2 Gene

Localization for NINJ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NINJ2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NINJ2 Gene COMPARTMENTS Subcellular localization image for NINJ2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NINJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10627596
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NINJ2: view

Pathways & Interactions for NINJ2 Gene

SuperPathways for NINJ2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NINJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007158 neuron cell-cell adhesion TAS 10627596
GO:0007399 nervous system development TAS 10627596
GO:0042246 tissue regeneration IEA --
genes like me logo Genes that share ontologies with NINJ2: view

No data available for Pathways by source and SIGNOR curated interactions for NINJ2 Gene

Transcripts for NINJ2 Gene

Unigene Clusters for NINJ2 Gene

Ninjurin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NINJ2 Gene

No ASD Table

Relevant External Links for NINJ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NINJ2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NINJ2 Gene

mRNA differential expression in normal tissues according to GTEx for NINJ2 Gene

This gene is overexpressed in Whole Blood (x9.3) and Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for NINJ2 Gene

This gene is overexpressed in Frontal cortex (51.3), Spinal cord (7.9), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NINJ2 Gene

Protein tissue co-expression partners for NINJ2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NINJ2 Gene:


SOURCE GeneReport for Unigene cluster for NINJ2 Gene:


mRNA Expression by UniProt/SwissProt for NINJ2 Gene:

Tissue specificity: Widely expressed. In adult, higher expression in the bone marrow and peripheral blood lymphocytes, medium in the lung, lymph node, thyroid, uterus, thymus, spleen, prostate and skeletal muscle, lower in the liver, placenta, brain, heart and kidney. In embryo, higher expression in the thymus, heart and liver, lower in the spleen, lung, brain and kidney.
genes like me logo Genes that share expression patterns with NINJ2: view

Primer Products

Orthologs for NINJ2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NINJ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NINJ2 34 35
  • 99.47 (n)
(Canis familiaris)
Mammalia NINJ2 34 35
  • 86.45 (n)
(Rattus norvegicus)
Mammalia Ninj2 34
  • 80.99 (n)
(Mus musculus)
Mammalia Ninj2 34 16 35
  • 77 (n)
(Bos Taurus)
Mammalia NINJ2 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia NINJ2 35
  • 65 (a)
(Monodelphis domestica)
Mammalia NINJ2 35
  • 53 (a)
(Gallus gallus)
Aves NINJ2 34 35
  • 68.26 (n)
(Anolis carolinensis)
Reptilia NINJ2 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ninj2 34
  • 71.11 (n)
(Danio rerio)
Actinopterygii ninj2 34 35
  • 67.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14394 35
  • 33 (a)
CG11637 35
  • 20 (a)
NijA 35
  • 18 (a)
Species where no ortholog for NINJ2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NINJ2 Gene

Gene Tree for NINJ2 (if available)
Gene Tree for NINJ2 (if available)

Paralogs for NINJ2 Gene

Paralogs for NINJ2 Gene

(1) SIMAP similar genes for NINJ2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NINJ2: view

Variants for NINJ2 Gene

Sequence variations from dbSNP and Humsavar for NINJ2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1052967 -- 645,110(+) CCTGC(A/G)TCCCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs10549771 -- 641,862(+) AAAAA(-/A)GCAGG intron-variant
rs10592628 -- 607,378(+) GATGA(-/TGA)CGACT intron-variant
rs1059781 -- 585,873(-) CTCCA(A/C/T)GCCCC intron-variant, nc-transcript-variant
rs10633920 -- 648,999(+) TGTCT(-/GTCTATCT/GTCTATCTATCT)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NINJ2 Gene

Variant ID Type Subtype PubMed ID
dgv1333n100 CNV gain 25217958
dgv1334n100 CNV gain 25217958
dgv174n27 CNV gain 19166990
dgv2251n54 CNV gain 21841781
dgv2252n54 CNV gain 21841781
dgv60n111 CNV duplication 26073780
esv1113146 CNV deletion 17803354
esv1449891 CNV deletion 17803354
esv1606062 CNV insertion 17803354
esv2249356 CNV deletion 18987734
esv2745360 CNV deletion 23290073
esv2745361 CNV deletion 23290073
esv2745362 CNV deletion 23290073
esv2745365 CNV deletion 23290073
esv2745366 CNV deletion 23290073
esv2759875 CNV gain+loss 17122850
esv2762957 CNV gain 21179565
esv29801 CNV loss 19812545
esv3374336 CNV duplication 20981092
esv3628245 CNV gain 21293372
esv3628246 CNV gain 21293372
esv3628248 CNV loss 21293372
esv3628249 CNV gain 21293372
esv3892122 CNV gain 25118596
esv3892123 CNV gain 25118596
esv989890 CNV deletion 20482838
esv995402 CNV deletion 20482838
nsv1040579 CNV gain 25217958
nsv1042529 CNV gain 25217958
nsv1050781 CNV loss 25217958
nsv1070998 CNV deletion 25765185
nsv1130663 CNV deletion 24896259
nsv1139583 CNV deletion 24896259
nsv1141224 CNV deletion 24896259
nsv1148736 CNV deletion 26484159
nsv1153792 CNV deletion 26484159
nsv468951 CNV gain 19166990
nsv470254 CNV gain 18288195
nsv519441 CNV gain 19592680
nsv527632 CNV loss 19592680
nsv556885 CNV gain 21841781
nsv556887 CNV gain 21841781
nsv556891 CNV loss 21841781
nsv556893 CNV gain 21841781
nsv556894 CNV gain 21841781
nsv556895 CNV gain 21841781
nsv818876 CNV gain 17921354
nsv826173 CNV loss 20364138
nsv826174 CNV gain 20364138
nsv957257 CNV deletion 24416366

Variation tolerance for NINJ2 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NINJ2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NINJ2 Gene

Disorders for NINJ2 Gene

Relevant External Links for NINJ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NINJ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NINJ2 Gene

Publications for NINJ2 Gene

  1. Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth. (PMID: 10627596) Araki T. … Milbrandt J. (J. Neurosci. 2000) 2 3 4 64
  2. Failure to validate association between 12p13 variants and ischemic stroke. (PMID: 20410525) (N. Engl. J. Med. 2010) 3 46 64
  3. Genomewide association studies of stroke. (PMID: 19369658) Ikram M.A. … Wolf P.A. (N. Engl. J. Med. 2009) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study. (PMID: 24664524) Zhu Y. … Hu Y. (J. Thromb. Thrombolysis 2014) 3 64

Products for NINJ2 Gene

Sources for NINJ2 Gene

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