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Aliases for NINJ1 Gene

Aliases for NINJ1 Gene

  • Ninjurin 1 2 3 5
  • Nerve Injury-Induced Protein-1 2 3
  • Nerve Injury-Induced Protein 1 3 4
  • NINJURIN 3
  • NIN1 3

External Ids for NINJ1 Gene

Previous GeneCards Identifiers for NINJ1 Gene

  • GC09M086710
  • GC09M087611
  • GC09M089182
  • GC09M091225
  • GC09M092963
  • GC09M094923
  • GC09M095883
  • GC09M065560

Summaries for NINJ1 Gene

Entrez Gene Summary for NINJ1 Gene

  • The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]

GeneCards Summary for NINJ1 Gene

NINJ1 (Ninjurin 1) is a Protein Coding gene. Diseases associated with NINJ1 include hereditary sensory neuropathy and acrocallosal syndrome. An important paralog of this gene is NINJ2.

UniProtKB/Swiss-Prot for NINJ1 Gene

  • Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.

Gene Wiki entry for NINJ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NINJ1 Gene

Genomics for NINJ1 Gene

Regulatory Elements for NINJ1 Gene

Promoters for NINJ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NINJ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NINJ1 Gene

Chromosome:
9
Start:
93,121,489 bp from pter
End:
93,134,304 bp from pter
Size:
12,816 bases
Orientation:
Minus strand

Genomic View for NINJ1 Gene

Genes around NINJ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NINJ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NINJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NINJ1 Gene

Proteins for NINJ1 Gene

  • Protein details for NINJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92982-NINJ1_HUMAN
    Recommended name:
    Ninjurin-1
    Protein Accession:
    Q92982
    Secondary Accessions:
    • Q6GU89
    • Q8WUV5
    • Q9BT07

    Protein attributes for NINJ1 Gene

    Size:
    152 amino acids
    Molecular mass:
    16345 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NINJ1 Gene

Proteomics data for NINJ1 Gene at MOPED

Post-translational modifications for NINJ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NINJ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NINJ1 Gene

Domains & Families for NINJ1 Gene

Protein Domains for NINJ1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NINJ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92982

UniProtKB/Swiss-Prot:

NINJ1_HUMAN :
  • Belongs to the ninjurin family.
Family:
  • Belongs to the ninjurin family.
genes like me logo Genes that share domains with NINJ1: view

No data available for Gene Families for NINJ1 Gene

Function for NINJ1 Gene

Molecular function for NINJ1 Gene

GENATLAS Biochemistry:
mouse ninjurin homolog,nerve injury induced protein,cell surface molecule,promoting axonal growth
UniProtKB/Swiss-Prot Function:
Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.
UniProtKB/Swiss-Prot Induction:
By nerve injury both in dorsal root ganglion neurons and in Schwann cells.
genes like me logo Genes that share phenotypes with NINJ1: view

Animal Models for NINJ1 Gene

MGI Knock Outs for NINJ1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NINJ1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NINJ1 Gene

Localization for NINJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NINJ1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NINJ1 Gene COMPARTMENTS Subcellular localization image for NINJ1 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NINJ1 Gene

Pathways & Interactions for NINJ1 Gene

SuperPathways for NINJ1 Gene

No Data Available

Interacting Proteins for NINJ1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364595%0d%0a9606.ENSP00000368698%0d%0a
Selected Interacting proteins: Q92982-NINJ1_HUMAN ENSP00000364595 for NINJ1 Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007399 nervous system development TAS 9261151
GO:1990384 hyaloid vascular plexus regression IEA --
genes like me logo Genes that share ontologies with NINJ1: view

No data available for Pathways by source and SIGNOR curated interactions for NINJ1 Gene

Drugs & Compounds for NINJ1 Gene

No Compound Related Data Available

Transcripts for NINJ1 Gene

Unigene Clusters for NINJ1 Gene

Ninjurin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NINJ1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for NINJ1 Gene

GeneLoc Exon Structure for
NINJ1
ECgene alternative splicing isoforms for
NINJ1

Expression for NINJ1 Gene

mRNA expression in normal human tissues for NINJ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NINJ1 Gene

This gene is overexpressed in Whole Blood (x11.6).

Protein differential expression in normal tissues from HIPED for NINJ1 Gene

This gene is overexpressed in Frontal cortex (8.3), Spinal cord (6.8), Testis (6.6), Monocytes (6.5), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NINJ1 Gene



SOURCE GeneReport for Unigene cluster for NINJ1 Gene Hs.494457

mRNA Expression by UniProt/SwissProt for NINJ1 Gene

Q92982-NINJ1_HUMAN
Tissue specificity: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.
genes like me logo Genes that share expression patterns with NINJ1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for NINJ1 Gene

Orthologs for NINJ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NINJ1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NINJ1 35
  • 86.98 (n)
  • 86.09 (a)
NINJ1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NINJ1 35
  • 88.74 (n)
  • 86.09 (a)
NINJ1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ninj1 35
  • 87.06 (n)
  • 89.47 (a)
Ninj1 16
Ninj1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NINJ1 35
  • 99.56 (n)
  • 98.68 (a)
NINJ1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ninj1 35
  • 87.06 (n)
  • 90.13 (a)
oppossum
(Monodelphis domestica)
Mammalia NINJ1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NINJ1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NINJ1 35
  • 68.53 (n)
  • 77.62 (a)
NINJ1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NINJ1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ninj1 35
  • 68.6 (n)
  • 71.74 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100150223 35
  • 67.15 (n)
  • 64.75 (a)
NINJ1 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11637 36
  • 21 (a)
ManyToMany
CG14394 36
  • 34 (a)
ManyToMany
NijA 36
  • 19 (a)
ManyToMany
Species with no ortholog for NINJ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NINJ1 Gene

ENSEMBL:
Gene Tree for NINJ1 (if available)
TreeFam:
Gene Tree for NINJ1 (if available)

Paralogs for NINJ1 Gene

Paralogs for NINJ1 Gene

(1) SIMAP similar genes for NINJ1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NINJ1: view

Variants for NINJ1 Gene

Sequence variations from dbSNP and Humsavar for NINJ1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2275848 - 93,125,038(+) GCTTG(G/T)CCGGG reference, missense
rs1127832 -- 93,122,033(-) TCTCA(A/G)CAGCT utr-variant-3-prime
rs1127851 -- 93,121,676(-) GGTCT(A/T)AAGTG utr-variant-3-prime
rs1127852 -- 93,121,649(-) ATCAA(A/G)AGGGA utr-variant-3-prime
rs1127857 -- 93,121,583(-) CCGGG(C/G)AGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NINJ1 Gene

Variant ID Type Subtype PubMed ID
nsv526296 CNV Loss 19592680
nsv893576 CNV Gain 21882294
dgv8260n71 CNV Loss 21882294
dgv8261n71 CNV Loss 21882294
nsv893580 CNV Loss 21882294
nsv824982 CNV Gain 20364138

Variation tolerance for NINJ1 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NINJ1 Gene

HapMap Linkage Disequilibrium report
NINJ1
Human Gene Mutation Database (HGMD)
NINJ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NINJ1 Gene

Disorders for NINJ1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NINJ1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hereditary sensory neuropathy
  • congenital insensitivity to pain
acrocallosal syndrome
  • joubert syndrome 12
- elite association - COSMIC cancer census association via MalaCards
Search NINJ1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NINJ1

Genetic Association Database (GAD)
NINJ1
Human Genome Epidemiology (HuGE) Navigator
NINJ1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NINJ1
genes like me logo Genes that share disorders with NINJ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NINJ1 Gene

Publications for NINJ1 Gene

  1. Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. (PMID: 8780658) Araki T. … Milbrandt J. (Neuron 1996) 2 3 4 23 67
  2. The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). (PMID: 9465296) Chadwick B.P. … Frischauf A.-M. (Genomics 1998) 3 23
  3. Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. (PMID: 9261151) Araki T. … Milbrandt J. (J. Biol. Chem. 1997) 3 23
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. (PMID: 23563609) Wheeler E. … Farooqi I.S. (Nat. Genet. 2013) 3

Products for NINJ1 Gene

Sources for NINJ1 Gene

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