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Aliases for NINJ1 Gene

Aliases for NINJ1 Gene

  • Ninjurin 1 2 3 5
  • Nerve Injury-Induced Protein-1 2 3
  • Nerve Injury-Induced Protein 1 4
  • Ninjurin-1 3
  • NINJURIN 3
  • NIN1 3

External Ids for NINJ1 Gene

Previous GeneCards Identifiers for NINJ1 Gene

  • GC09M086710
  • GC09M087611
  • GC09M089182
  • GC09M091225
  • GC09M092963
  • GC09M094923
  • GC09M095883
  • GC09M065560

Summaries for NINJ1 Gene

Entrez Gene Summary for NINJ1 Gene

  • The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]

GeneCards Summary for NINJ1 Gene

NINJ1 (Ninjurin 1) is a Protein Coding gene. Diseases associated with NINJ1 include Hereditary Sensory Neuropathy. An important paralog of this gene is NINJ2.

UniProtKB/Swiss-Prot for NINJ1 Gene

  • Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.

Gene Wiki entry for NINJ1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NINJ1 Gene

Genomics for NINJ1 Gene

Regulatory Elements for NINJ1 Gene

Enhancers for NINJ1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G093125 1.6 FANTOM5 ENCODE dbSUPER 54.9 +3.7 3733 10.1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF766 ZNF143 NINJ1 CARD19 ZNF484 LOC101927993 SUSD3 PHF2 IPPK
GH09G093110 2.1 FANTOM5 Ensembl ENCODE dbSUPER 33.3 +20.5 20478 6.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 NINJ1 NOL8 PHF2 CARD19 SUSD3 LINC00475 IPPK WNK2 FGD3 FAM120A
GH09G093118 2 FANTOM5 Ensembl ENCODE dbSUPER 34.3 +14.1 14097 3.2 HDGF PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 FOS NINJ1 CARD19 SUSD3 IPPK PHF2
GH09G093090 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23.8 +38.6 38635 9.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 FEZF1 ZBTB7B YY1 ZNF766 ZNF207 NINJ1 CARD19 SUSD3 NOL8 IPPK PHF2 LOC101927993
GH09G093148 0.8 FANTOM5 dbSUPER 42.4 -14.7 -14689 0.5 HNF4A NINJ1 ENSG00000203364 CARD19 IPPK WNK2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NINJ1 on UCSC Golden Path with GeneCards custom track

Promoters for NINJ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000237999 304 1201 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF766 ZNF143

Genomic Location for NINJ1 Gene

Chromosome:
9
Start:
93,121,489 bp from pter
End:
93,134,304 bp from pter
Size:
12,816 bases
Orientation:
Minus strand

Genomic View for NINJ1 Gene

Genes around NINJ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NINJ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NINJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NINJ1 Gene

Proteins for NINJ1 Gene

  • Protein details for NINJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92982-NINJ1_HUMAN
    Recommended name:
    Ninjurin-1
    Protein Accession:
    Q92982
    Secondary Accessions:
    • Q6GU89
    • Q8WUV5
    • Q9BT07

    Protein attributes for NINJ1 Gene

    Size:
    152 amino acids
    Molecular mass:
    16345 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NINJ1 Gene

Post-translational modifications for NINJ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NINJ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NINJ1 Gene

Domains & Families for NINJ1 Gene

Protein Domains for NINJ1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NINJ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92982

UniProtKB/Swiss-Prot:

NINJ1_HUMAN :
  • Belongs to the ninjurin family.
Family:
  • Belongs to the ninjurin family.
genes like me logo Genes that share domains with NINJ1: view

No data available for Gene Families for NINJ1 Gene

Function for NINJ1 Gene

Molecular function for NINJ1 Gene

GENATLAS Biochemistry:
mouse ninjurin homolog,nerve injury induced protein,cell surface molecule,promoting axonal growth
UniProtKB/Swiss-Prot Function:
Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.
UniProtKB/Swiss-Prot Induction:
By nerve injury both in dorsal root ganglion neurons and in Schwann cells.

Gene Ontology (GO) - Molecular Function for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NINJ1: view
genes like me logo Genes that share phenotypes with NINJ1: view

Animal Models for NINJ1 Gene

MGI Knock Outs for NINJ1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NINJ1 Gene

Localization for NINJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NINJ1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NINJ1 gene
Compartment Confidence
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NINJ1: view

Pathways & Interactions for NINJ1 Gene

SuperPathways for NINJ1 Gene

No Data Available

Interacting Proteins for NINJ1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364595%0d%0a9606.ENSP00000361141%0d%0a9606.ENSP00000333744%0d%0a
Selected Interacting proteins: ENSP00000364595 Q92982-NINJ1_HUMAN for NINJ1 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0007155 cell adhesion TAS,IEA --
GO:0007399 nervous system development TAS 9261151
GO:0042246 tissue regeneration IEA --
GO:1990384 hyaloid vascular plexus regression IEA --
genes like me logo Genes that share ontologies with NINJ1: view

No data available for Pathways by source and SIGNOR curated interactions for NINJ1 Gene

Transcripts for NINJ1 Gene

Unigene Clusters for NINJ1 Gene

Ninjurin 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NINJ1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for NINJ1 Gene

GeneLoc Exon Structure for
NINJ1
ECgene alternative splicing isoforms for
NINJ1

Expression for NINJ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NINJ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NINJ1 Gene

This gene is overexpressed in Whole Blood (x11.6).

Protein differential expression in normal tissues from HIPED for NINJ1 Gene

This gene is overexpressed in Frontal cortex (8.3), Spinal cord (6.8), Testis (6.6), Monocytes (6.5), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NINJ1 Gene



NURSA nuclear receptor signaling pathways regulating expression of NINJ1 Gene:

NINJ1

SOURCE GeneReport for Unigene cluster for NINJ1 Gene:

Hs.494457

mRNA Expression by UniProt/SwissProt for NINJ1 Gene:

Q92982-NINJ1_HUMAN
Tissue specificity: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.

Evidence on tissue expression from TISSUES for NINJ1 Gene

  • Lung(4.4)
  • Skin(4.3)
  • Nervous system(2.4)
  • Bone marrow(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with NINJ1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NINJ1 Gene

Orthologs for NINJ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NINJ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NINJ1 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia NINJ1 34 35
  • 88.74 (n)
mouse
(Mus musculus)
Mammalia Ninj1 34 16 35
  • 87.06 (n)
rat
(Rattus norvegicus)
Mammalia Ninj1 34
  • 87.06 (n)
cow
(Bos Taurus)
Mammalia NINJ1 34 35
  • 86.98 (n)
oppossum
(Monodelphis domestica)
Mammalia NINJ1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NINJ1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NINJ1 34 35
  • 68.53 (n)
lizard
(Anolis carolinensis)
Reptilia NINJ1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ninj1 34
  • 68.6 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100150223 34
  • 67.15 (n)
NINJ1 35
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14394 35
  • 34 (a)
ManyToMany
CG11637 35
  • 21 (a)
ManyToMany
NijA 35
  • 19 (a)
ManyToMany
Species where no ortholog for NINJ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NINJ1 Gene

ENSEMBL:
Gene Tree for NINJ1 (if available)
TreeFam:
Gene Tree for NINJ1 (if available)

Paralogs for NINJ1 Gene

Paralogs for NINJ1 Gene

(1) SIMAP similar genes for NINJ1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NINJ1: view

Variants for NINJ1 Gene

Sequence variations from dbSNP and Humsavar for NINJ1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000086894 -- 93,121,918(+) CTTGA(A/G)TGGGT utr-variant-3-prime
rs1000195074 -- 93,122,833(+) CAGAC(C/G)CAGCA intron-variant
rs1000349185 -- 93,133,059(+) ATTGC(C/T)CCAAA intron-variant
rs1000415519 -- 93,122,548(+) CCCGG(A/G)CTCAG intron-variant
rs1000632855 -- 93,127,240(+) GGCCA(C/T)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NINJ1 Gene

Variant ID Type Subtype PubMed ID
nsv1128505 CNV deletion 24896259
nsv1134927 CNV tandem duplication 24896259
nsv1161884 CNV deletion 26073780
nsv526296 CNV loss 19592680
nsv614879 CNV loss 21841781
nsv824982 CNV gain 20364138

Variation tolerance for NINJ1 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NINJ1 Gene

Human Gene Mutation Database (HGMD)
NINJ1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NINJ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NINJ1 Gene

Disorders for NINJ1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NINJ1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hereditary sensory neuropathy
  • congenital insensitivity to pain
- elite association - COSMIC cancer census association via MalaCards
Search NINJ1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NINJ1

Genetic Association Database (GAD)
NINJ1
Human Genome Epidemiology (HuGE) Navigator
NINJ1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NINJ1
genes like me logo Genes that share disorders with NINJ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NINJ1 Gene

Publications for NINJ1 Gene

  1. Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. (PMID: 8780658) Araki T. … Milbrandt J. (Neuron 1996) 2 3 4 22 64
  2. The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). (PMID: 9465296) Chadwick B.P. … Frischauf A.-M. (Genomics 1998) 3 4 22 64
  3. Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. (PMID: 9261151) Araki T. … Milbrandt J. (J. Biol. Chem. 1997) 3 4 22 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. DNA polymorphisms as tools for spinal cord injury research. (PMID: 18504448) GuimarALes P.E. … Dias-Neto E. (Spinal Cord 2009) 3 46 64

Products for NINJ1 Gene

Sources for NINJ1 Gene

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