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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NINJ1 Gene

protein-coding   GIFtS: 57
GCID: GC09M095883

Ninjurin 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ninjurin 11 2
Nerve Injury-Induced Protein-11 2
Nerve Injury-Induced Protein 12 3
NIN12
NINJURIN2
ninjurin-12

External Ids:    HGNC: 78241   Entrez Gene: 48142   Ensembl: ENSG000001316697   OMIM: 6020625   UniProtKB: Q929823   

Export aliases for NINJ1 gene to outside databases

Previous GC identifers: GC09M086710 GC09M087611 GC09M089182 GC09M091225 GC09M092963 GC09M094923 GC09M065560


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NINJ1 Gene:
The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells
(Araki and Milbrandt, 1996 (PubMed 8780658)). It demonstrates properties of a homophilic adhesion molecule and
promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.(supplied by OMIM, Aug 2009)

GeneCards Summary for NINJ1 Gene: 
NINJ1 (ninjurin 1) is a protein-coding gene. Diseases associated with NINJ1 include hereditary sensory neuropathy, and acrocallosal syndrome. An important paralog of this gene is NINJ2.

UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982
Function: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and
in the formation and function of other tissues. Cell adhesion requires divalent cations

Gene Wiki entry for NINJ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NINJ1 gene promoter:
         AML1a   Pax-5   GATA-3   p53   Bach2   E47   FOXO4   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNINJ1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NINJ1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NINJ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22

NINJ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NINJ1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095883:  view genomic region     (about GC identifiers)

Start:
95,883,771 bp from pter      End:
95,896,570 bp from pter
Size:
12,800 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982 (See protein sequence)
Recommended Name: Ninjurin-1  
Size: 152 amino acids; 16345 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q6GU89 Q8WUV5 Q9BT07

Explore the universe of human proteins at neXtProt for NINJ1: NX_Q92982

Explore proteomics data for NINJ1 at MOPED 

NINJ1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

NINJ1 Protein Expression

REFSEQ proteins: NP_004139.2  
ENSEMBL proteins: 
 ENSP00000364595  

Human Recombinant Protein Products for NINJ1: 
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Sino Biological Cell Lysate for NINJ1 
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Cloud-Clone Corp. Proteins for NINJ1 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

NINJ1 for ontologies           About GeneDecksing



NINJ1 Antibody Products: 
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Cloud-Clone Corp. CLIAs for NINJ1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR007007 Ninjurin
 IPR015639 Ninjurin1

Graphical View of Domain Structure for InterPro Entry Q92982

ProtoNet protein and cluster: Q92982

1 Blocks protein domain: IPB007007 Ninjurin

UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982
Similarity: Belongs to the ninjurin family


NINJ1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: NINJ1_HUMAN, Q92982
Function: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and
in the formation and function of other tissues. Cell adhesion requires divalent cations
Induction: By nerve injury both in dorsal root ganglion neurons and in Schwann cells

     Genatlas biochemistry entry for NINJ1:
mouse ninjurin homolog,nerve injury induced protein,cell surface molecule,promoting axonal growth

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for NINJ1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NINJ1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NINJ1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NINJ1 

miRNA
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8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NINJ1 (see all 10):
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SwitchGear 3'UTR luciferase reporter plasmidNINJ1 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NINJ1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NINJ1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

3 Interacting proteins for NINJ1 (Q929823 ENSP000003645954) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
GRK5P349473I2D: score=1 
PRRC2BQ5JSZ53I2D: score=1 
HIVEP1ENSP000003686984STRING: ENSP00000368698
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007155cell adhesion IEA--
GO:0007399nervous system development TAS9261151
GO:0042246tissue regeneration IEA--

NINJ1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NINJ1

Search CenterWatch for drugs/clinical trials and news about NINJ1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NINJ1 gene: 
NM_004148.3  

Unigene Cluster for NINJ1:

Ninjurin 1
Hs.494457  [show with all ESTs]
Unigene Representative Sequence: BQ073581
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000375446(uc004atg.4) ENST00000489274 ENST00000470314 ENST00000461162
ENST00000490564
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
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8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NINJ1 (see all 10):
hsa-miR-4324 hsa-miR-875-3p hsa-miR-206 hsa-miR-1237 hsa-miR-1 hsa-miR-544b hsa-miR-138 hsa-miR-613
SwitchGear 3'UTR luciferase reporter plasmidNINJ1 3' UTR sequence
Inhib. RNA
Products:
     
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for NINJ1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NINJ1
Sirion Biotech Customized lentivirus for stable overexpression of NINJ1 
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Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NINJ1

Additional mRNA sequence: 

BC000298.1 BC004440.1 BC019336.1 BC048212.1 BT007164.1 U72661.1 U91512.1 

6 DOTS entries:

DT.454040  DT.100036792  DT.100800807  DT.121197044  DT.75152083  DT.97817039 

24/216 AceView cDNA sequences (see all 216):

CA841919 AW298524 BT007164 BM993195 CR595190 AA453984 CR608271 BI905974 
AW245283 BX379571 BQ925212 BM671171 BM998359 BQ024718 BE313817 CA405509 
CB528308 BQ652545 AV693467 BC019336 BU500647 BX402488 BM888156 BG332010 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for NINJ1    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1:                                      -     -                           
SP2:                    -                 -     -                           
SP3:                    -     -           -     -                           
SP4:                                                                        
SP5:                    -                                                   


ECgene alternative splicing isoforms for NINJ1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NINJ1 expression in normal human tissues (normalized intensities)      NINJ1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATGAACAAT
NINJ1 Expression
About this image


NINJ1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Bone (Muscoskeletal System)
         Zeugopod Epiphyseal End
 
 Blood (Hematopoietic System)
         leukocytes   

See NINJ1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NINJ1

SOURCE GeneReport for Unigene cluster: Hs.494457

UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982
Tissue specificity: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin

    SABiosciences Custom PCR Arrays for NINJ1
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NINJ1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NINJ1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NINJ1 gene from 5/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ninj11 , 5 ninjurin 11, 5 87.06(n)1
89.47(a)1
  13 (25.14 cM)5
180811  NM_013610.21  NP_038638.11 
 491874855 
chicken
(Gallus gallus)
Aves NINJ11 ninjurin 1 68.53(n)
77.62(a)
  415986  XM_414328.3  XP_414328.1 
lizard
(Anolis carolinensis)
Reptilia NINJ16
Uncharacterized protein
61(a)
1 ↔ 1
GL343225.1(1845206-1868058)
zebrafish
(Danio rerio)
Actinopterygii LOC1001502231 ninjurin-1-like 67.39(n)
65.22(a)
  100150223  XM_001918989.1  XP_001919024.1 
fruit fly
(Drosophila melanogaster)
Insecta CG143946
CG116376
(see all 3)
--
34(a)
21(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
3R(8520868-8523265)
3L(18885483-18886378)


ENSEMBL Gene Tree for NINJ1 (if available)
TreeFam Gene Tree for NINJ1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for NINJ1 gene
NINJ22  
1 SIMAP similar gene for NINJ1 using alignment to 1 protein entry:     NINJ1_HUMAN:
NINJ2

NINJ1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/354 SNPs in NINJ1 are shown (see all 354)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs19544351,2
C,F,H--95883363(+) CCTGTG/ACCCAG 1 -- int122Minor allele frequency- A:0.25NS EA NA WA CSA 2312
rs1892850551,2
--95883398(+) ATCACC/TGGACA 1 -- int10--------
rs1816489721,2
--95883506(+) GGAAAC/TATGTG 1 -- int10--------
rs1857756601,2
--95883554(+) TGGGTA/CAGAGG 1 -- int10--------
rs1912684411,2
--95883757(+) AGCCCC/TGGGAA 1 -- int10--------
rs70336381,2
C,F,A--95883785(+) GAGCCA/C/TGACAA 2 -- ut31 ese316EA NA WA CSA 591
rs122387601,2
C,F--95883846(+) CCCCCG/ATGGAG 1 -- ut31 ese31Minor allele frequency- A:0.17EA 120
rs11278571,2
C,F,H--95883865(-) CCGGGC/GAGAGC 1 -- ut3120Minor allele frequency- G:0.07MN NA NS EA WA CSA 1205
rs11278521,2
C,H--95883931(-) ATCAAG/AAGGGA 1 -- ut31 ese312Minor allele frequency- A:0.00MN EA NS NA 1072
rs11278511,2
C,F,A,H--95883958(-) GGTCTA/TAAGTG 1 -- ut31 ese328Minor allele frequency- T:0.18MN NA NS EA WA CSA 1577

HapMap Linkage Disequilibrium report for NINJ1 (95883771 - 95896570 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for NINJ1:    About this table     
Variant IDTypeSubtypePubMed ID
dgv8261n71CNV Loss21882294
dgv8260n71CNV Loss21882294
nsv893580CNV Loss21882294
nsv526296CNV Loss19592680
nsv824982CNV Gain20364138
nsv893576CNV Gain21882294


Human Gene Mutation Database (HGMD): NINJ1
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing NINJ1
DNA2.0 Custom Variant and Variant Library Synthesis for NINJ1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 602062    OMIM disorders: --

11 diseases for NINJ1:    About MalaCards
hereditary sensory neuropathy    acrocallosal syndrome    spinal cord injury    leprosy
viral hepatitis    neuronitis    neuropathy    multiple sclerosis
hepatocellular carcinoma    hepatitis    lung cancer

1 disease from the University of Copenhagen DISEASES database for NINJ1:
Acrocallosal syndrome

NINJ1 for disorders           About GeneDecksing

Genetic Association Database (GAD): NINJ1
Human Genome Epidemiology (HuGE) Navigator: NINJ1 (6 documents)

Export disorders for NINJ1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NINJ1 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with NINJ1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. (PubMed id 8780658)1, 2, 3, 9 Araki T. and Milbrandt J. (1996)
  2. Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. (PubMed id 9261151)1, 2, 9 Araki T.... Milbrandt J. (1997)
  3. The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). (PubMed id 9465296)1, 2, 9 Chadwick B.P.... Frischauf A.-M. (1998)
  4. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
  5. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
  6. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
  7. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
  8. DNA polymorphisms as tools for spinal cord injury research. (PubMed id 18504448)1, 4 Guimaraes P.E....Dias-Neto E. (2008)
  9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4814 HGNC: 7824 AceView: NINJ1 Ensembl:ENSG00000131669 euGenes: HUgn4814
ECgene: NINJ1 H-InvDB: NINJ1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NINJ1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NINJ1 gene:
Search GeneIP for patents involving NINJ1

GeneCards and IP:
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