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Aliases for NINJ1 Gene

Aliases for NINJ1 Gene

  • Ninjurin 1 2 3
  • Nerve Injury-Induced Protein-1 2 3
  • Nerve Injury-Induced Protein 1 3 4
  • Ninjurin-1 3
  • NINJURIN 3
  • NIN1 3

External Ids for NINJ1 Gene

Previous GeneCards Identifiers for NINJ1 Gene

  • GC09M086710
  • GC09M087611
  • GC09M089182
  • GC09M091225
  • GC09M092963
  • GC09M094923
  • GC09M095883
  • GC09M065560

Summaries for NINJ1 Gene

Entrez Gene Summary for NINJ1 Gene

  • The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]

GeneCards Summary for NINJ1 Gene

NINJ1 (Ninjurin 1) is a Protein Coding gene. Diseases associated with NINJ1 include acrocallosal syndrome and spinal cord injury. An important paralog of this gene is NINJ2.

UniProtKB/Swiss-Prot for NINJ1 Gene

  • Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations

Gene Wiki entry for NINJ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NINJ1 Gene

Genomics for NINJ1 Gene

Regulatory Elements for NINJ1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NINJ1 Gene

Start:
93,121,489 bp from pter
End:
93,134,288 bp from pter
Size:
12,800 bases
Orientation:
Minus strand

Genomic View for NINJ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NINJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NINJ1 Gene

Proteins for NINJ1 Gene

  • Protein details for NINJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92982-NINJ1_HUMAN
    Recommended name:
    Ninjurin-1
    Protein Accession:
    Q92982
    Secondary Accessions:
    • Q6GU89
    • Q8WUV5
    • Q9BT07

    Protein attributes for NINJ1 Gene

    Size:
    152 amino acids
    Molecular mass:
    16345 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NINJ1 Gene

Proteomics data for NINJ1 Gene at MOPED

Post-translational modifications for NINJ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NINJ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NINJ1 Gene

Domains for NINJ1 Gene

Protein Domains for NINJ1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NINJ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92982

UniProtKB/Swiss-Prot:

NINJ1_HUMAN :
  • Q92982
Family:
  • Belongs to the ninjurin family.
genes like me logo Genes that share domains with NINJ1: view

No data available for Gene Families for NINJ1 Gene

Function for NINJ1 Gene

Molecular function for NINJ1 Gene

GENATLAS Biochemistry:
mouse ninjurin homolog,nerve injury induced protein,cell surface molecule,promoting axonal growth
UniProtKB/Swiss-Prot Function:
Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations
UniProtKB/Swiss-Prot Induction:
By nerve injury both in dorsal root ganglion neurons and in Schwann cells

Gene Ontology (GO) - Molecular Function for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NINJ1: view

Phenotypes for NINJ1 Gene

genes like me logo Genes that share phenotypes with NINJ1: view

miRNA for NINJ1 Gene

miRTarBase miRNAs that target NINJ1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NINJ1 Gene

Localization for NINJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NINJ1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NINJ1 Gene COMPARTMENTS Subcellular localization image for NINJ1 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NINJ1: view

Pathways for NINJ1 Gene

SuperPathways for NINJ1 Gene

No Data Available

Interacting Proteins for NINJ1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364595%0d%0a9606.ENSP00000368698%0d%0a
Selected Interacting proteins: ENSP00000364595 Q92982-NINJ1_HUMAN for NINJ1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0007155 cell adhesion IEA --
GO:0007399 nervous system development TAS 9261151
GO:0042246 tissue regeneration IEA --
GO:1990384 hyaloid vascular plexus regression IEA --
genes like me logo Genes that share ontologies with NINJ1: view

No data available for Pathways by source for NINJ1 Gene

Transcripts for NINJ1 Gene

Unigene Clusters for NINJ1 Gene

Ninjurin 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NINJ1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NINJ1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for NINJ1 Gene

GeneLoc Exon Structure for
NINJ1
ECgene alternative splicing isoforms for
NINJ1

Expression for NINJ1 Gene

mRNA expression in normal human tissues for NINJ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NINJ1 Gene

This gene is overexpressed in Whole Blood (11.6).

Protein differential expression in normal tissues for NINJ1 Gene

This gene is overexpressed in Frontal cortex (8.3), Spinal cord (6.8), Testis (6.6), Monocytes (6.5), and Ovary (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NINJ1 Gene

SOURCE GeneReport for Unigene cluster for NINJ1 Gene Hs.494457

mRNA Expression by UniProt/SwissProt for NINJ1 Gene

Q92982-NINJ1_HUMAN
Tissue specificity: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin
genes like me logo Genes that share expressions with NINJ1: view

In Situ Assay Products

No data available for Expression partners for NINJ1 Gene

Orthologs for NINJ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NINJ1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NINJ1 35
  • 86.98 (n)
  • 86.09 (a)
NINJ1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NINJ1 35
  • 88.74 (n)
  • 86.09 (a)
NINJ1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ninj1 35
  • 87.06 (n)
  • 89.47 (a)
Ninj1 16
Ninj1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NINJ1 35
  • 99.56 (n)
  • 98.68 (a)
NINJ1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ninj1 35
  • 87.06 (n)
  • 90.13 (a)
oppossum
(Monodelphis domestica)
Mammalia NINJ1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NINJ1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NINJ1 35
  • 68.53 (n)
  • 77.62 (a)
NINJ1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NINJ1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ninj1 35
  • 68.6 (n)
  • 71.74 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100150223 35
  • 67.15 (n)
  • 64.75 (a)
NINJ1 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11637 36
  • 21 (a)
ManyToMany
CG14394 36
  • 34 (a)
ManyToMany
NijA 36
  • 19 (a)
ManyToMany
Species with no ortholog for NINJ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NINJ1 Gene

ENSEMBL:
Gene Tree for NINJ1 (if available)
TreeFam:
Gene Tree for NINJ1 (if available)

Paralogs for NINJ1 Gene

Paralogs for NINJ1 Gene

Selected SIMAP similar genes for NINJ1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NINJ1: view

Variants for NINJ1 Gene

Sequence variations from dbSNP and Humsavar for NINJ1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1106192 -- 93,134,304(+) cggcc(C/G)gcccc upstream-variant-2KB
rs1127832 -- 93,122,033(-) TCTCA(A/G)CAGCT utr-variant-3-prime
rs1127851 -- 93,121,676(-) GGTCT(A/T)AAGTG utr-variant-3-prime
rs1127852 -- 93,121,649(-) ATCAA(A/G)AGGGA utr-variant-3-prime
rs1127857 -- 93,121,583(-) CCGGG(C/G)AGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NINJ1 Gene

Variant ID Type Subtype PubMed ID
nsv526296 CNV Loss 19592680
nsv893576 CNV Gain 21882294
dgv8260n71 CNV Loss 21882294
dgv8261n71 CNV Loss 21882294
nsv893580 CNV Loss 21882294
nsv824982 CNV Gain 20364138

Relevant External Links for NINJ1 Gene

HapMap Linkage Disequilibrium report
NINJ1
Human Gene Mutation Database (HGMD)
NINJ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NINJ1 Gene

Disorders for NINJ1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NINJ1 Gene in MalaCards »

(4) Diseases for NINJ1 Gene including...

(1) University of Copenhagen DISEASES for NINJ1 Gene

Relevant External Links for NINJ1

Genetic Association Database (GAD)
NINJ1
Human Genome Epidemiology (HuGE) Navigator
NINJ1
genes like me logo Genes that share disorders with NINJ1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for NINJ1 Gene

Publications for NINJ1 Gene

  1. Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. (PMID: 8780658) Araki T. … Milbrandt J. (Neuron 1996) 2 3 4 23
  2. Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. (PMID: 9261151) Araki T. … Milbrandt J. (J. Biol. Chem. 1997) 3 4 23
  3. The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). (PMID: 9465296) Chadwick B.P. … Frischauf A.-M. (Genomics 1998) 3 4 23
  4. DNA polymorphisms as tools for spinal cord injury research. (PMID: 18504448) GuimarALes P.E. … Dias-Neto E. (Spinal Cord 2009) 3 48
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 48

Products for NINJ1 Gene

Sources for NINJ1 Gene

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