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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NINJ1 Gene

protein-coding   GIFtS: 53
GCID: GC09M095883

ninjurin 1

 Explore 12 diseases affiliated with
NINJ1 via our new
 Human Malady Compendium 
Biological research products
for NINJ1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ninjurin 11 2
NIN11 2
Nerve Injury-Induced Protein 12 3
NINJURIN2
Nerve Injury-Induced Protein-12
Ninjurin-11

External Ids:    HGNC: 78241   Entrez Gene: 48142   Ensembl: ENSG000001316697   OMIM: 6020625   UniProtKB: Q929823   

Export aliases for NINJ1 gene to outside databases

Previous GC identifers: GC09M086710 GC09M087611 GC09M089182 GC09M091225 GC09M092963 GC09M094923 GC09M065560


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NINJ1:
The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki
and Milbrandt, 1996 (PubMed 8780658)). It demonstrates properties of a homophilic adhesion molecule and promotes
neurite outgrowth from primary cultured dorsal root ganglion neurons.(supplied by OMIM, Aug 2009)

UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982
Function: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in
the formation and function of other tissues. Cell adhesion requires divalent cations

Gene Wiki entry for NINJ1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NINJ1 gene promoter:
         AML1a   Pax-5   GATA-3   p53   Bach2   E47   FOXO4   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNINJ1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NINJ1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NINJ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22

NINJ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NINJ1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095883:  view genomic region     (about GC identifiers)

Start:
95,883,771 bp from pter      End:
95,896,570 bp from pter
Size:
12,800 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982 (See protein sequence)
Recommended Name: Ninjurin-1  
Size: 152 amino acids; 16345 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q6GU89 Q8WUV5 Q9BT07

Explore the universe of human proteins at neXtProt for NINJ1: NX_Q92982

NINJ1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_004139.2  
ENSEMBL proteins: 
 ENSP00000364595  

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Uscn Proteins for NINJ1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--


NINJ1 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for NINJ1


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NINJ1 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR007007 Ninjurin
 IPR015639 Ninjurin1

Graphical View of Domain Structure for InterPro Entry Q92982

ProtoNet protein and cluster: Q92982

1 Blocks protein family: IPB007007 Ninjurin

UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982
Similarity: Belongs to the ninjurin family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982
Function: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in
the formation and function of other tissues. Cell adhesion requires divalent cations
Induction: By nerve injury both in dorsal root ganglion neurons and in Schwann cells

     Genatlas biochemistry entry for NINJ1:
mouse ninjurin homolog,nerve injury induced protein,cell surface molecule,promoting axonal growth

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidNINJ1 3' UTR sequence
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NINJ1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

3 Interacting proteins for NINJ1 (Q929823 ENSP000003645954) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
GRK5P349473I2D: score=1 
PRRC2BQ5JSZ53I2D: score=1 
HIVEP1ENSP000003686984STRING: ENSP00000368698
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007155cell adhesion IEA--
GO:0007399nervous system development TAS9261151
GO:0042246tissue regeneration IEA--


NINJ1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NINJ1
Search CenterWatch for drugs/clinical trials and news about NINJ1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NINJ1 gene: 
NM_004148.3  

Unigene Cluster for NINJ1:

Ninjurin 1
Hs.494457  [show with all ESTs]
Unigene Representative Sequence: BQ073581
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000375446(uc004atg.4) ENST00000489274 ENST00000470314 ENST00000461162
ENST00000490564

miRNA
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hsa-miR-4324 hsa-miR-875-3p hsa-miR-206 hsa-miR-1237 hsa-miR-1 hsa-miR-544b hsa-miR-138 hsa-miR-613
SwitchGear 3'UTR luciferase reporter plasmidNINJ1 3' UTR sequence
Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NINJ1

Additional cDNA sequence: 

BC000298.1 BC004440.1 BC019336.1 BC048212.1 BT007164.1 U72661.1 U91512.1 

6 DOTS entries:

DT.454040  DT.100036792  DT.100800807  DT.121197044  DT.75152083  DT.97817039 

24/216 AceView cDNA sequences (see all 216):

AW298524 CA841919 BM993195 CR608271 AA453984 CR595190 BT007164 BM023132 
BG530047 BU197282 BG337131 BM996164 AW627748 CB997007 BE938416 BG468136 
BQ652545 BQ215033 AI620184 BM142434 BG477478 BU839762 BQ712522 U91512 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for NINJ1    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1:                                      -     -                           
SP2:                    -                 -     -                           
SP3:                    -     -           -     -                           
SP4:                                                                        
SP5:                    -                                                   


ECgene alternative splicing isoforms for NINJ1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NINJ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGAACAAT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

NINJ1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
PureStem™ progenitor W8 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See NINJ1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NINJ1

SOURCE GeneReport for Unigene cluster: Hs.494457

UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982
Tissue specificity: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin

    SABiosciences Custom PCR Arrays for NINJ1
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NINJ1 gene from 4/15 species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves NINJ11 ninjurin 1 68.53(n)
77.62(a)
  415986  XM_414328.3  XP_414328.1 
lizard
(Anolis carolinensis)
Reptilia NINJ16
--
71(a)
1 ↔ 1
GL343225.1(1845206-1868058)
zebrafish
(Danio rerio)
Actinopterygii LOC1001502231 ninjurin-1-like 67.39(n)
65.22(a)
  100150223  XM_001918989.1  XP_001919024.1 
fruit fly
(Drosophila melanogaster)
Insecta CG143946
CG116376
(see all 3)
--
35(a)
24(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
3R(8520868-8523265)
3L(18885483-18886378)


ENSEMBL Gene Tree for NINJ1 (if available)
TreeFam Gene Tree for NINJ1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for NINJ1 gene
NINJ22  
1 SIMAP similar gene for NINJ1 using alignment to 1 protein entry:     NINJ1_HUMAN:
NINJ2

NINJ1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/292 NCBI SNPs in NINJ1 are shown (see all 292    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs19544351,2
C,F,H,--95883363(+) CCTGTG/ACCCAG 1 -- int122Minor allele frequency- A:0.25NS EA NA WA CSA 2312
rs1892850551,2
--95883398(+) ATCACC/TGGACA 1 -- int10--------
rs1816489721,2
--95883506(+) GGAAAC/TATGTG 1 -- int10--------
rs1857756601,2
--95883554(+) TGGGTA/CAGAGG 1 -- int10--------
rs1912684411,2
--95883757(+) AGCCCC/TGGGAA 1 -- int10--------
rs70336381,2
C,F,A,--95883785(+) GAGCCA/C/TGACAA 2 -- ut31 ese316EA NA WA CSA 591
rs122387601,2
F,--95883846(+) CCCCCG/ATGGAG 1 -- ut31 ese31Minor allele frequency- A:0.17EA 120
rs11278571,2
C,F,H,--95883865(-) CCGGGC/GAGAGC 1 -- ut3120Minor allele frequency- G:0.07MN NA NS EA WA CSA 1205
rs11278521,2
C,H--95883931(-) ATCAAG/AAGGGA 1 -- ut31 ese312Minor allele frequency- A:0.00MN EA NS NA 1072
rs11278511,2
C,F,A,H,--95883958(-) GGTCTA/TAAGTG 1 -- ut31 ese328Minor allele frequency- T:0.18MN NA NS EA WA CSA 1577

HapMap Linkage Disequilibrium report for NINJ1 (95883771 - 95896570 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for NINJ1: --
Human Gene Mutation Database (HGMD): NINJ1

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NINJ1 for disorders           About GeneDecksing

OMIM gene information: 602062    OMIM disorders: --

12 diseases for NINJ1:    About MalaCards
spinal cord injury    hereditary sensory neuropathy    acrocallosal syndrome    neuronitis
viral hepatitis    multiple sclerosis    leprosy    neuropathy
pulmonary disease    hepatocellular carcinoma    hepatitis    carcinoma

1 disease from the University of Copenhagen DISEASES database for NINJ1:
Acrocallosal syndrome
Human Genome Epidemiology (HuGE) Navigator: NINJ1 (6 documents)

Export disorders for NINJ1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NINJ1 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with NINJ1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. (PubMed id 8780658)1, 2, 3, 9 Araki T. and Milbrandt J. (1996)
  2. Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. (PubMed id 9261151)1, 2, 9 Araki T.... Milbrandt J. (1997)
  3. The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). (PubMed id 9465296)1, 2, 9 Chadwick B.P.... Frischauf A.-M. (1998)
  4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. NINJURIN1 single nucleotide polymorphism and nerve dam age in leprosy. (PubMed id 22326538)1 Graca C.R....Baptista Rossit A.R. (2012)
  7. Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions. (PubMed id 22162058)1 Ifergan I....Prat A. (2011)
  8. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
  9. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1 Hosgood H.D....Lan Q. (2009)
  10. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1 Shen M....Lan Q. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 4814 HGNC: 7824 AceView: NINJ1 Ensembl:ENSG00000131669 euGenes: HUgn4814
ECgene: NINJ1 H-InvDB: NINJ1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for NINJ1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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