NINJ1 Gene
protein-coding GIFtS : 53
GCID: GC09 M095883
ninjurin 1
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Aliasesfor NINJ1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ninjurin 1 1 2 NIN11 2 Nerve Injury-Induced Protein 12 3 NINJURIN2 Nerve Injury-Induced Protein-12 Ninjurin-11
Export aliases for NINJ1 gene to outside databases Previous GC identifers: GC09M086710 GC09M087611 GC09M089182 GC09M091225 GC09M092963 GC09M094923 GC09M065560
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Summariesfor NINJ1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for NINJ1 : The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 (PubMed 8780658)). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.(supplied by OMIM, Aug 2009) UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982 Function : Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and inthe formation and function of other tissues. Cell adhesion requires divalent cations Gene Wiki entry for NINJ1
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Genomic Viewsfor NINJ1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008470.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NINJ1 gene promoter: AML1a Pax-5 GATA-3 p53 Bach2 E47 FOXO4 NF-kappaB1 ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for NINJ1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NINJ1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q22 Ensembl cytogenetic band: 9q22.31 HGNC cytogenetic band: 9q22 NINJ1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M095883: view genomic region
(about GC identifiers )
Start:
95,883,771 bp from pter
End:
95,896,570 bp from pter
Size:
12,800 bases
Orientation:
minus strand
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Proteinsfor NINJ1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982 (See
protein sequence )Recommended Name: Ninjurin-1 Size : 152 amino acids; 16345 Da
Subcellular location : Membrane; Multi-pass membrane protein
Secondary accessions : Q6GU89 Q8WUV5 Q9BT07Explore the universe of human proteins at neXtProt for NINJ1: NX_Q92982 NINJ1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_004139.2 ENSEMBL proteins: ENSP00000364595 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
NINJ1 for ontologies About GeneDecksing NINJ1 Antibody Products: Assay Products for NINJ1:
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Protein
Domains / Familiesfor NINJ1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NINJ1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q92982 ProtoNet protein and cluster: Q92982
1 Blocks protein family : IPB007007 Ninjurin UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982 Similarity : Belongs to the ninjurin family
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Functionfor NINJ1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982 Function : Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and inthe formation and function of other tissues. Cell adhesion requires divalent cations Induction : By nerve injury both in dorsal root ganglion neurons and in Schwann cells
Genatlas biochemistry entry for NINJ1 : mouse ninjurin homolog,nerve injury induced protein,cell surface molecule,promoting axonal growth Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NINJ1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NINJ1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NINJ1 (NM_004148 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NINJ1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NINJ1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NINJ1
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Pathways & Interactionsfor NINJ1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NINJ1 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)3 Interacting proteins for NINJ1 (Q92982 3 ENSP00000364595 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
NINJ1 for ontologies About GeneDecksing
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Drugs & Compoundsfor NINJ1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NINJ1 Search CenterWatch for drugs/clinical trials and news about NINJ1
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Transcriptsfor NINJ1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NINJ1 gene: NM_004148.3 Unigene Cluster for NINJ1:
Ninjurin 1 Hs.494457 [show with all ESTs ] Unigene Representative Sequence: BQ073581 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000375446 (uc004atg.4 ) ENST00000489274 ENST00000470314 ENST00000461162 ENST00000490564 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NINJ1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NINJ1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NINJ1 (NM_004148 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NINJ1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NINJ1
Additional cDNA sequence: BC000298.1 BC004440.1 BC019336.1 BC048212.1 BT007164.1 U72661.1 U91512.1
6 DOTS entries : DT.454040 DT.100036792
DT.100800807 DT.121197044 DT.75152083 DT.97817039 24/216 AceView cDNA sequences (see all 216 ):
AW298524 CA841919 BM993195 CR608271 AA453984 CR595190 BT007164 BM023132 BG530047 BU197282 BG337131 BM996164 AW627748 CB997007 BE938416 BG468136 BQ652545 BQ215033 AI620184 BM142434 BG477478 BU839762 BQ712522 U91512 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for NINJ1 About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c SP1 :             -   -           SP2 :       -       -   -           SP3 :       -   -     -   -           SP4 :                         SP5 :       -                  
ECgene alternative splicing isoforms for NINJ1
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Expression for NINJ1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NINJ1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AATGAACAAT
About this image NINJ1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor W8 (Embryonic Progenitor Cell)Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See NINJ1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NINJ1 SOURCE GeneReport for Unigene cluster: Hs.494457 UniProtKB/Swiss-Prot: NINJ1_HUMAN, Q92982 Tissue specificity : Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin SABiosciences Custom PCR Arrays for NINJ1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NINJ1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat NINJ1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NINJ1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NINJ1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NINJ1
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Orthologsfor NINJ1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for NINJ1 gene from 4/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for NINJ1 (if available)TreeFam Gene Tree for NINJ1 (if available)
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Paralogsfor NINJ1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for NINJ1 gene NINJ2 2 1 SIMAP similar gene for NINJ1 using alignment to 1 protein entry: NINJ1_HUMAN :NINJ2
NINJ1 for paralogs About GeneDecksing
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Genomic Variantsfor NINJ1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for NINJ1 (95883771 - 95896570 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NINJ1: -- Human Gene Mutation Database (HGMD) : NINJ1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NINJ1
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Disorders
/ Diseasesfor NINJ1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
NINJ1 for disorders About GeneDecksing
OMIM gene information: 602062
OMIM disorders : --12 diseases for NINJ1 : About MalaCards spinal cord injury hereditary sensory neuropathy acrocallosal syndrome neuronitis viral hepatitis multiple sclerosis leprosy neuropathy pulmonary disease hepatocellular carcinoma hepatitis carcinoma 1 disease from the University of Copenhagen DISEASES database for NINJ1 :Acrocallosal syndrome Human Genome Epidemiology (HuGE) Navigator: NINJ1 (6 documents) Export disorders for NINJ1 gene to outside databases
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Publicationsfor NINJ1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NINJ1 gene, integrated from 9 sources (see all 28 ): (articles sorted by number of sources associating them with NINJ1) Utopia : connect your pdf to the dynamic world of online information
Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. (PubMed id 8780658) 1 , 2 , 3, 9 Araki T. and Milbrandt J. (1996) Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. (PubMed id 9261151) 1 , 2 , 9 Araki T.... Milbrandt J. (1997) The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). (PubMed id 9465296) 1 , 2 , 9 Chadwick B.P.... Frischauf A.-M. (1998) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 1 , 2 Humphray S.J.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) NINJURIN1 single nucleotide polymorphism and nerve dam age in leprosy. (PubMed id 22326538) 1 Graca C.R....Baptista Rossit A.R. (2012) Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions. (PubMed id 22162058) 1 Ifergan I....Prat A. (2011) Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168) 1 Guey L.T....Malats N. (2010) PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176) 1 Hosgood H.D....Lan Q. (2009) Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196) 1 Shen M....Lan Q. (2009)
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External Searches for NINJ1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NINJ1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NINJ1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing NINJ1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for NINJ1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NINJ1 gene: Search GeneIP for patents involving NINJ1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NINJ1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for NINJ1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for NINJ1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NINJ1 OriGene Protein Over-expression Lysate for NINJ1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NINJ1 OriGene 3'-UTR Clone for NINJ1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NINJ1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NINJ1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NINJ1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NINJ1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NINJ1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat NINJ1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NINJ1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NINJ1
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NINJ1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NINJ1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NINJ1
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