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Aliases for NIN Gene

Aliases for NIN Gene

  • Ninein (GSK3B Interacting Protein) 2 3
  • Glycogen Synthase Kinase 3 Beta-Interacting Protein 3 4
  • KIAA1565 4 6
  • HNinein 3 4
  • SCKL7 3 6
  • Ninein Centrosomal Protein 3
  • GSK3B-Interacting Protein 4
  • Ninein 3

External Ids for NIN Gene

Previous GeneCards Identifiers for NIN Gene

  • GC14M048508
  • GC14M044982
  • GC14M049176
  • GC14M050256
  • GC14M051187
  • GC14M031312

Summaries for NIN Gene

Entrez Gene Summary for NIN Gene

  • This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for NIN Gene

NIN (Ninein (GSK3B Interacting Protein)) is a Protein Coding gene. Diseases associated with NIN include seckel syndrome 7 and microcephalic primordial dwarfism, dauber type. GO annotations related to this gene include calcium ion binding and GTP binding. An important paralog of this gene is NINL.

UniProtKB/Swiss-Prot for NIN Gene

  • Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules.

Gene Wiki entry for NIN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIN Gene

Genomics for NIN Gene

Regulatory Elements for NIN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NIN Gene

Start:
50,719,763 bp from pter
End:
50,831,121 bp from pter
Size:
111,359 bases
Orientation:
Minus strand

Genomic View for NIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIN Gene

Proteins for NIN Gene

  • Protein details for NIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4C6-NIN_HUMAN
    Recommended name:
    Ninein
    Protein Accession:
    Q8N4C6
    Secondary Accessions:
    • A6NDB8
    • B7WPA3
    • C9JSB6
    • C9JSG2
    • C9JXL2
    • Q5BKU3
    • Q6P0P6
    • Q9BWU6
    • Q9C012
    • Q9C013
    • Q9C014
    • Q9H5I6
    • Q9HAT7
    • Q9HBY5
    • Q9HCK7
    • Q9UH61

    Protein attributes for NIN Gene

    Size:
    2090 amino acids
    Molecular mass:
    243249 Da
    Quaternary structure:
    • Homooligomer. Interacts with GSK3B/GSK3-beta via its C-terminal domain. Interacts with C14ORF166, such interaction may prevent its phosphorylation by GSK3B. Interacts with AUNIP (via N-terminus). Identified in a complex with AUNIP and AURKA.
    Miscellaneous:
    • Antibodies against NIN are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins
    SequenceCaution:
    • Sequence=AAH65521.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH65521.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAK00628.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=AAK00629.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors and frameshifts.; Evidence={ECO:0000305}; Sequence=AAK00630.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=BAB13391.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NIN Gene

neXtProt entry for NIN Gene

Proteomics data for NIN Gene at MOPED

Post-translational modifications for NIN Gene

  • Phosphorylated by AURKA/Aurora kinase A and PKA kinases but not CK2 or AURKB/ Aurora kinase B.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NIN Gene

Domains for NIN Gene

Gene Families for NIN Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for NIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NIN Gene

Graphical View of Domain Structure for InterPro Entry

Q8N4C6

UniProtKB/Swiss-Prot:

NIN_HUMAN :
  • Q8N4C6
Domain:
  • The coiled coil region from Asn-1611 to Pro-1693 is necessary and sufficient for the targeting to centrosome
  • Contains 5 EF-hand domains.
genes like me logo Genes that share domains with NIN: view

Function for NIN Gene

Molecular function for NIN Gene

UniProtKB/Swiss-Prot Function:
Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules.

Gene Ontology (GO) - Molecular Function for NIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 11004522
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with NIN: view

Phenotypes for NIN Gene

GenomeRNAi human phenotypes for NIN:
genes like me logo Genes that share phenotypes with NIN: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NIN Gene

Localization for NIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIN Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIN Gene COMPARTMENTS Subcellular localization image for NIN gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IMP 18331714
GO:0005730 nucleolus IDA --
GO:0005813 centrosome IDA --
GO:0005814 centriole IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with NIN: view

Pathways for NIN Gene

SuperPathways for NIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034454 microtubule anchoring at centrosome IEA --
GO:0051642 centrosome localization TAS 16154161
GO:0090222 centrosome-templated microtubule nucleation IEA --
genes like me logo Genes that share ontologies with NIN: view

No data available for Pathways by source for NIN Gene

Compounds for NIN Gene

(1) HMDB Compounds for NIN Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for NIN Gene

Compound -log(P) Hits PubMed IDs
leucine 17 1
genes like me logo Genes that share compounds with NIN: view

Transcripts for NIN Gene

Unigene Clusters for NIN Gene

Ninein (GSK3B interacting protein):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6:
SP7:
SP8:
SP9: - -
SP10: - -
SP11: - -
SP12:
SP13:
SP14:

ExUns: 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5:
SP6: - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 34c · 34d · 34e ^ 35a · 35b · 35c
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - -

Relevant External Links for NIN Gene

GeneLoc Exon Structure for
NIN
ECgene alternative splicing isoforms for
NIN

Expression for NIN Gene

mRNA expression in normal human tissues for NIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NIN Gene

This gene is overexpressed in Whole Blood (5.3).

Protein differential expression in normal tissues for NIN Gene

This gene is overexpressed in Uterus (26.0) and Peripheral blood mononuclear cells (12.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NIN Gene

SOURCE GeneReport for Unigene cluster for NIN Gene Hs.310429

mRNA Expression by UniProt/SwissProt for NIN Gene

Q8N4C6-NIN_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5.
genes like me logo Genes that share expressions with NIN: view

Expression partners for NIN Gene

In Situ Assay Products

Orthologs for NIN Gene

This gene was present in the common ancestor of animals.

Orthologs for NIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NIN 35
  • 87.98 (n)
  • 87.05 (a)
NIN 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIN 35
  • 87.86 (n)
  • 86.07 (a)
NIN 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nin 35
  • 81.67 (n)
  • 79.24 (a)
Nin 16
Nin 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NIN 35
  • 99.47 (n)
  • 99.34 (a)
NIN 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nin 35
  • 82.04 (n)
  • 78.74 (a)
oppossum
(Monodelphis domestica)
Mammalia NIN 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves NIN 35
  • 66.34 (n)
  • 61.26 (a)
NIN 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIN 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nin 35
  • 62.1 (n)
  • 58.52 (a)
Str.20462 35
zebrafish
(Danio rerio)
Actinopterygii nin 36
  • 22 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bsg25D 36
  • 17 (a)
OneToMany
Species with no ortholog for NIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NIN Gene

ENSEMBL:
Gene Tree for NIN (if available)
TreeFam:
Gene Tree for NIN (if available)

Paralogs for NIN Gene

Paralogs for NIN Gene

genes like me logo Genes that share paralogs with NIN: view

Variants for NIN Gene

Sequence variations from dbSNP and Humsavar for NIN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11376 Likely benign 50,738,278(-) CGTCA(A/G)TTGGA synonymous-codon, reference
rs722797 -- 50,743,215(-) AGGTG(A/G)GCAGA intron-variant
rs764964 -- 50,788,190(-) TGGGT(A/G)GAATG intron-variant
rs764965 -- 50,788,330(-) TCAGG(C/T)TTCAT intron-variant
rs1004832 -- 50,818,417(+) ATAGA(C/G)AGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NIN Gene

Variant ID Type Subtype PubMed ID
nsv832794 CNV Gain 17160897

Relevant External Links for NIN Gene

HapMap Linkage Disequilibrium report
NIN
Human Gene Mutation Database (HGMD)
NIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIN Gene

Disorders for NIN Gene

(1) OMIM Diseases for NIN Gene (608684)

UniProtKB/Swiss-Prot

NIN_HUMAN
  • Seckel syndrome 7 (SCKL7) [MIM:614851]: A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation. {ECO:0000269 PubMed:22933543}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for NIN Gene

Relevant External Links for NIN

Genetic Association Database (GAD)
NIN
Human Genome Epidemiology (HuGE) Navigator
NIN
genes like me logo Genes that share disorders with NIN: view

No data available for Novoseek inferred disease relationships and Genatlas for NIN Gene

Publications for NIN Gene

  1. Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta. (PMID: 11004522) Hong Y.-R. … Howng S.-L. (Biochim. Biophys. Acta 2000) 2 3 4 23
  2. Genomic organization and molecular characterization of the human ninein gene. (PMID: 11162463) Hong Y.-R. … Howng S.-L. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  3. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. (PMID: 11956314) Ou Y.Y. … Rattner J.B. (J. Cell Sci. 2002) 3 4 23
  4. Assembly of centrosomal proteins and microtubule organization depends on PCM-1. (PMID: 12403812) Dammermann A. … Merdes A. (J. Cell Biol. 2002) 3 4 23
  5. Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. (PMID: 9506584) Mack G.J. … Rattner J.B. (Arthritis Rheum. 1998) 3 4 23

Products for NIN Gene

Sources for NIN Gene

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