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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NIN Gene

protein-coding GIFtS: 56
GCID: GC14M051187

ninein (GSK3B interacting protein)

Explore 17 diseases affiliated with
NIN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ninein (GSK3B Interacting Protein)¹ ²		Ninein¹
Glycogen Synthase Kinase 3 Beta-Interacting Protein² ³		Ninein Centrosomal Protein²
HNinein¹		KIAA1565³
SCKL7²		GSK3B-Interacting Protein³

External Ids:	HGNC: 14906¹	Entrez Gene: 51199²	Ensembl: ENSG00000100503⁷	OMIM: 608684⁵	UniProtKB: Q8N4C6³

Export aliases for NIN gene to outside databases

Previous GC identifers: GC14M048508 GC14M044982 GC14M049176 GC14M050256 GC14M031312

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NIN:

This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and

anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires

three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that

encode different isoforms have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NIN_HUMAN, Q8N4C6

Function: Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial

cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does

not perturb nucleation or elongation of microtubules but suppresses release of microtubules

Gene Wiki entry for NIN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NIN gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 Nkx2-5 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NIN promoter sequence

Search SABiosciences Chromatin IP Primers for NIN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q21-q22

NIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NIN gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M051187: view genomic region (about GC identifiers)

Start:	51,186,481 bp from pter	End:	51,297,839 bp from pter
Size:	111,359 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NIN_HUMAN, Q8N4C6 (See protein sequence)

Recommended Name: Ninein

Size: 2090 amino acids; 243249 Da

Subunit: Homooligomer. Interacts with GSK3B/GSK3-beta via its C-terminus domain. Interacts with C14ORF166, such

interaction may prevent its phosphorylation by GSK3B. Interacts with AUNIP (via N-terminus). Identified in a complex

with AUNIP and AURKA

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Note=Component of the core centrosome. Arranged in a tubular

conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends

of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present

only at the closed end. Requires PCM1 for centrosome localization

Developmental stage: In interphase cells, it is localized in the centrosome. Decreases in metaphase and anaphase and

reappears in telophase

Miscellaneous: Antibodies against NIN are present in sera from patients with autoimmune diseases that developed

autoantibodies against centrosomal proteins

Sequence caution: Sequence=AAH65521.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=AAH65521.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAK00628.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors; Sequence=AAK00629.1;

Type=Miscellaneous discrepancy; Note=Several sequencing errors and frameshifts; Sequence=AAK00630.1;

Type=Miscellaneous discrepancy; Note=Several sequencing errors; Sequence=BAB13391.2; Type=Erroneous initiation;

Note=Translation N-terminally shortened; Sequence=BAB15640.1; Type=Erroneous initiation; Note=Translation N-terminally

extended;

Secondary accessions: A6NDB8 B7WPA3 C9JSB6 C9JSG2 C9JXL2 Q5BKU3 Q6P0P6 Q9BWU6 Q9C012 Q9C013 Q9C014

Q9H5I6 Q9HAT7 Q9HBY5 Q9HCK7 Q9UH61

Alternative splicing: 9 isoforms: Q8N4C6-1 Q8N4C6-2 Q8N4C6-10 Q8N4C6-4 Q8N4C6-5 Q8N4C6-6 Q8N4C6-7 Q8N4C6-9

Q8N4C6-11 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NIN: NX_Q8N4C6

Post-translational modifications:

Phosphorylated by AURKA/Aurora kinase A and PKA kinases but not CK2 or AURKB/ Aurora kinase B¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N4C6

NIN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_057434.4 NP_065972.3 NP_891989.2 NP_891991.1

ENSEMBL proteins:

ENSP00000432924 ENSP00000436092 ENSP00000371474 ENSP00000374519 ENSP00000371472

ENSP00000433717 ENSP00000431485 ENSP00000398641 ENSP00000431826 ENSP00000245441

ENSP00000412391 ENSP00000374518 ENSP00000324210

Human Recombinant Protein Products for NIN:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for NIN
	GenScript Custom Purified and Recombinant Proteins Services for NIN
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NIN

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005813	centrosome	IDA	12927815
GO:0005814	centriole	IEA	--
GO:0005874	microtubule	IEA	--

NIN for ontologies About GeneDecksing

NIN Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NIN
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NIN
	GenScript Superior Antibodies for NIN
	Novus Biologicals NIN Antibodies
	Abcam antibodies for NIN
	Uscn Antibodies for NIN
	Search ThermoFisher Antibodies for NIN

Assay Products for NIN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NIN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NIN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NIN for domains About GeneDecksing

2 InterPro domains/families:

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

Graphical View of Domain Structure for InterPro Entry Q8N4C6

ProtoNet protein and cluster: Q8N4C6

UniProtKB/Swiss-Prot: NIN_HUMAN, Q8N4C6

Domain: The coiled coil region from Asn-1611 to Pro-1693 is necessary and sufficient for the targeting to centrosome

Similarity: Contains 5 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NIN_HUMAN, Q8N4C6

Function: Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial

cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does

not perturb nucleation or elongation of microtubules but suppresses release of microtubules

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	15147888
GO:0005525	GTP binding	IEA	--

NIN for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NIN:

Increased HPV18 LCR reporter a

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NIN

miRNA Products:		OriGene 3'-UTR Clone (see all 4): NIN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NIN
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NIN (see all 18):
		hsa-miR-125a-5p hsa-miR-429 hsa-miR-106a hsa-miR-519a hsa-miR-125b hsa-miR-93 hsa-miR-200b hsa-miR-526b*

		SwitchGear 3'UTR luciferase reporter plasmid: NIN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NIN (see all 7) OriGene shRNA RFP: NIN OriGene siRNA: NIN
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NIN

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NIN
			Sirion Biotech Customized adenovirus for overexpression of NIN Sirion Biotech Customized adenovirus for potent knockdown of NIN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIN (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIN (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NIN (NM_004148)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NIN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NIN
		Search LifeMap BioReagents cell lines for NIN
		Sirion Biotech Customized stable knockdown cell line services for NIN Sirion Biotech Customized inducible knockdown cell line services for NIN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIN

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NIN

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/14 Interacting proteins for NIN (Q8N4C6^{1, 2, 3} ENSP00000245441⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GSK3B	P49841¹^,²^,³, ENSP00000324806⁴	EBI-1164022,EBI-373586 MINT-4049773 I2D: score=5 STRING: ENSP00000324806
ABI1	Q8IZP0²^,³, ENSP00000365312⁴	MINT-45993 I2D: score=2 STRING: ENSP00000365312
AXIN1	O15169²^,³, ENSP00000262320⁴	MINT-7229769 I2D: score=1 STRING: ENSP00000262320
C14orf166	Q9Y224¹^,³, ENSP00000261700⁴	EBI-1164022,EBI-1104547 I2D: score=3 STRING: ENSP00000261700
BICD1	Q96G01²^,³, ENSP00000281474⁴	MINT-4049971 I2D: score=2 STRING: ENSP00000281474

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0034454	microtubule anchoring at centrosome	IEA	--
GO:0051642	centrosome localization	TAS	16154161
GO:0090222	centrosome-templated microtubule nucleation	IEA	--

NIN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NIN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NIN

1 HMDB Compound for NIN About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 Novoseek chemical compound relationship for NIN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	17	1	15190203 (1)

Search CenterWatch for drugs/clinical trials and news about NIN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NIN gene (5 alternative transcripts):

NM_016350.4 NM_020921.3 NM_182944.2 NM_182946.1 NM_182945.1

Unigene Cluster for NIN:

Ninein (GSK3B interacting protein)

Hs.310429 [show with all ESTs]

Unigene Representative Sequence: NM_020921

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000476352 ENST00000530997 ENST00000555984 ENST00000382043 ENST00000389869

ENST00000382041(uc001wym.2 uc001wyk.3 uc001wyp.1) ENST00000530853(uc001wyn.3)

ENST00000485005 ENST00000555509 ENST00000480476 ENST00000453401 ENST00000474937

ENST00000486950 ENST00000486200 ENST00000496749 ENST00000463419 ENST00000245441(uc001wyi.3)

ENST00000453196(uc001wyo.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): NIN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NIN
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NIN (see all 18):
		hsa-miR-125a-5p hsa-miR-429 hsa-miR-106a hsa-miR-519a hsa-miR-125b hsa-miR-93 hsa-miR-200b hsa-miR-526b*

		SwitchGear 3'UTR luciferase reporter plasmid: NIN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NIN (see all 7) OriGene shRNA RFP: NIN OriGene siRNA: NIN
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NIN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIN (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIN (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NIN (NM_004148)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NIN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIN Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIN

Additional cDNA sequence:

AB046785.2 AF186776.1 AF212162.2 AF223937.1 AF223938.1 AF223939.1 AF302773.2 AK025652.1

AK026083.1 AK027054.1 AL359571.1 AY027794.1 AY027795.1 AY027796.1 AY736182.1 AY736183.1

BC034708.2 BC065521.1 BC090932.1 BC141977.1

23 DOTS entries:

DT.411475 DT.120758029 DT.95171085 DT.445078 DT.100778149 DT.95171080 DT.101970522 DT.106975

DT.99992757 DT.97846526 DT.120757980 DT.86847508 DT.91745656 DT.92026148 DT.92461863 DT.120758020

DT.120758071 DT.40212388 DT.91745655 DT.91886690 DT.91916468 DT.92050985 DT.92461861

24/222 AceView cDNA sequences (see all 222):

AA886425 AW237766 AK026083 BG612081 C00658 AI632254 AI368051 AB046785

H47908 NM_020921 AA631557 BE504448 BQ023967 BQ024972 AA481587 F09800

BU607537 NM_182945 BQ024145 AI823678 BF438747 AA904345 CA308224 BM458320

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for NIN (see all 14) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15a	·
SP1:							-		-												-		-						-		-
SP2:							-		-												-		-						-		-
SP3:							-		-												-		-						-		-
SP4:																					-		-						-		-
SP5:							-		-				-								-		-						-		-

ExUns:	15b	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22a	·	22b	^	23	^	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29	^	30	^	31	^	32	^	33a	·	33b	^	34a	·	34b	·
SP1:							-																																						-		-		-
SP2:							-						-																																-		-		-
SP3:							-																																		-				-		-		-
SP4:							-						-																												-				-		-		-
SP5:

ExUns:	34c	·	34d	·	34e	^	35a	·	35b	·	35c
SP1:
SP2:	-		-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for NIN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NIN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTAAGGGA

About this image

NIN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NIN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NIN

SOURCE GeneReport for Unigene cluster: Hs.310429

UniProtKB/Swiss-Prot: NIN_HUMAN, Q8N4C6

Tissue specificity: Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform

SABiosciences Custom PCR Arrays for NIN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NIN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIN gene from 7/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NIN¹	ninein (GSK3B interacting protein)	65.81(n) 60.55(a)		428928 XM_426482.3 XP_426482.3
lizard (Anolis carolinensis)	Reptilia	NIN⁶	--	62(a)	1 ↔ 1	GL343845.1(16871-54829)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.20462²	Transcribed sequence with weak similarity to protein more	76(n)		142026540
zebrafish (Danio rerio)	Actinopterygii	nin¹	ninein (GSK3B interacting protein)	50.01(n) 39.38(a)		571879 XM_695518.5 XP_700610.5
honey bee (Apis mellifera)	Insecta	-- --	--	9(a) 6(a)	possible ortholog 1 ↔ many	Group8.17(54593-62455) GroupUn.9(154139-167900)
thale cress (Arabidopsis thaliana)	eudicotyledons	CIP1⁶ AT1G64330⁶ (see all 4)	myosin heavy chain-related protein (see all 4)	9(a) 8(a) (see all 4)	possible ortholog possible ortholog (see all 4)	5(16727530-16732847) 1(23870905-23874198)
rice (Oryza sativa)	Liliopsida	--	retrotransposon protein, putative, unclassified, e...	9(a)	possible ortholog	4(31002238-31010796)

ENSEMBL Gene Tree for NIN (if available)
TreeFam Gene Tree for NIN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NIN gene

NINL²

1 SIMAP similar gene for NIN using alignment to 10 protein entries: NIN_HUMAN (see all proteins):

NIN/PDGFRB fusion

NIN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs59096640^1,2	C,F	--	31311976(+)	`ATTCTG/CATTTA`	1	--	ds500¹		5		NA WA EA	362
rs73295424^1,2	C	--	31312197(+)	`AATATA/GCAAAG`	1	--	ut3¹		2		WA	120
rs45487099^1,2	C,F	--	31312220(+)	`NNNNAC/ATCATT`	1	--	ut3¹		1		NA	120
rs4534750^1,2	C,F,H	--	31313708(+)	`CAACCG/ATGATC`	1	--	ut3¹ ese³		23		NS EA NA WA	2610
rs8021903^1,2	C,F,A,H	--	31313815(+)	`TACTTA/GGTTTA`	1	--	ut3¹ ese³		9		NS EA NA WA	636
rs45558232^1,2	C,F	--	31314338(+)	`CAAAGC/TGAACT`	1	--	ut3¹		9		NA WA CSA EA	370
rs75313789^1,2	C,F	--	31314641(+)	`GAAAAT/GTNNNN`	1	--	ut3¹		1		NA	120
rs115891177^1,2	C	--	31315365(+)	`GTTTTA/CAAATA`	1	--	ut3¹		0	--	--	--	--
rs79716951^1,2	C	--	31315454(+)	`AAAAAC/ACCAAA`	1	--	ut3¹		1		WA	2
rs76623432^1,2	C,F	--	31316278(+)	`ATTTAT/CTCTTT`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for NIN (51186481 - 51297839 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NIN: --
Human Gene Mutation Database (HGMD): NIN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIN

DNA2.0 Custom Variant and Variant Library Synthesis for NIN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NIN for disorders About GeneDecksing

OMIM gene information: 608684 OMIM disorders: --

UniProtKB/Swiss-Prot: NIN_HUMAN, Q8N4C6

Defects in NIN are the cause of Seckel syndrome 7 (SCKL7) [MIM:614851]. A rare autosomal recessive disorder

characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe

microcephaly with a bird-headed like appearance, and mental retardation

17 diseases for NIN: About MalaCards

geniculate herpes zoster herpes zoster systemic lupus erythematosus lupus erythematosus

cerebellar ataxia myeloproliferative disorder diabetic cataract rheumatoid arthritis

cataract ataxia arthritis pancreatic cancer

lung cancer breast cancer pancreatitis malaria

neuronitis

1 disease from the University of Copenhagen DISEASES database for NIN:

Diabetic cataract

Human Genome Epidemiology (HuGE) Navigator: NIN (5 documents)

Export disorders for NIN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NIN gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with NIN)

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Genomic organization and molecular characterization of the human ninein gene. (PubMed id 11162463)^{1, 2, 3, 9} Hong Y.-R.... Howng S.-L. (2000)
Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta. (PubMed id 11004522)^{1, 2, 3, 9} Hong Y.-R....Howng S.-L. (2000)
CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. (PubMed id 11956314)^{1, 2, 9} Ou Y.Y.... Rattner J.B. (2002)
A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. (PubMed id 15147888)^{1, 2, 9} Howng S.-L....Hong Y.-R. (2004)
Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation. (PubMed id 15190203)^{1, 2, 9} Stillwell E.E.... Joshi H.C. (2004)
Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle. (PubMed id 12927815)^{1, 2, 9} Chen C.-H....Hong Y.-R. (2003)
Assembly of centrosomal proteins and microtubule organization depends on PCM-1. (PubMed id 12403812)^{1, 2, 9} Dammermann A. and Merdes A. (2002)
Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. (PubMed id 9506584)^{1, 2, 9} Mack G.J....Rattner J.B. (1998)
Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia. (PubMed id 14503922)^{1, 2, 9} Fritzler M.J.... Rattner J.B. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51199	HGNC: 14906	AceView: NIN	Ensembl:ENSG00000100503	euGenes: HUgn51199
ECgene: NIN	H-InvDB: NIN

(According to HUGE)
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HUGE: KIAA1565

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NIN	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NIN	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NIN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NIN gene:
Search GeneIP for patents involving NIN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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ninein (GSK3B interacting protein)

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NIN Gene

ninein (GSK3B interacting protein)

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