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Aliases for NIM1K Gene

Aliases for NIM1K Gene

  • NIM1 Serine/Threonine Protein Kinase 2 3
  • NIM1 Serine/Threonine-Protein Kinase 3 4
  • EC 2.7.11.1 4 63
  • NIM1 3 4
  • Serine/Threonine-Protein Kinase NIM1 3
  • EC 2.7.11 63

External Ids for NIM1K Gene

Summaries for NIM1K Gene

GeneCards Summary for NIM1K Gene

NIM1K (NIM1 Serine/Threonine Protein Kinase) is a Protein Coding gene. An important paralog of this gene is MARK4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIM1K Gene

Genomics for NIM1K Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NIM1K Gene

Start:
43,192,054 bp from pter
End:
43,280,850 bp from pter
Size:
88,797 bases
Orientation:
Plus strand

Genomic View for NIM1K Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIM1K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIM1K Gene

No data available for Regulatory Elements for NIM1K Gene

Proteins for NIM1K Gene

  • Protein details for NIM1K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY84-NIM1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase NIM1
    Protein Accession:
    Q8IY84
    Secondary Accessions:
    • B3KVM1

    Protein attributes for NIM1K Gene

    Size:
    436 amino acids
    Molecular mass:
    49606 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NIM1K Gene

Proteomics data for NIM1K Gene at MOPED

Selected DME Specific Peptides for NIM1K Gene

Post-translational modifications for NIM1K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NIM1K Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for NIM1K Gene

Graphical View of Domain Structure for InterPro Entry

Q8IY84

UniProtKB/Swiss-Prot:

NIM1_HUMAN :
  • Q8IY84
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NIM1K: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NIM1K Gene

Function for NIM1K Gene

Molecular function for NIM1K Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation at Thr-229, probably by autophosphorylation.

Enzyme Numbers (IUBMB) for NIM1K Gene

Gene Ontology (GO) - Molecular Function for NIM1K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15733851
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 15733851
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IDA 15733851
genes like me logo Genes that share ontologies with NIM1K: view

Phenotypes for NIM1K Gene

GenomeRNAi human phenotypes for NIM1K:
genes like me logo Genes that share phenotypes with NIM1K: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NIM1K Gene

Localization for NIM1K Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NIM1K Gene

Pathways for NIM1K Gene

SuperPathways for NIM1K Gene

No Data Available

Interacting Proteins for NIM1K Gene

Gene Ontology (GO) - Biological Process for NIM1K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 15733851
genes like me logo Genes that share ontologies with NIM1K: view

No data available for Pathways by source for NIM1K Gene

Transcripts for NIM1K Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NIM1K

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIM1K Gene

No ASD Table

Relevant External Links for NIM1K Gene

GeneLoc Exon Structure for
NIM1K
ECgene alternative splicing isoforms for
NIM1K

Expression for NIM1K Gene

mRNA expression in normal human tissues for NIM1K Gene

mRNA differential expression in normal tissues according to GTEx for NIM1K Gene

This gene is overexpressed in Brain - Cortex (4.7), Brain - Frontal Cortex (BA9) (4.7), and Brain - Nucleus accumbens (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NIM1K Gene

genes like me logo Genes that share expressions with NIM1K: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NIM1K Gene

Orthologs for NIM1K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NIM1K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471558 35
  • 99.46 (n)
  • 99.54 (a)
NIM1K 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NIM1 35
  • 89.22 (n)
  • 94.04 (a)
NIM1K 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIM1 35
  • 87.69 (n)
  • 93.58 (a)
NIM1K 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nim1 16
Nim1 36
  • 92 (a)
OneToOne
Nim1k 35
  • 87.23 (n)
  • 91.74 (a)
oppossum
(Monodelphis domestica)
Mammalia NIM1K 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIM1K 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nim1 35
  • 87.39 (n)
  • 91.74 (a)
chicken
(Gallus gallus)
Aves NIM1 35
  • 73.09 (n)
  • 77.98 (a)
NIM1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIM1K 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491267 35
  • 73.62 (n)
  • 76.15 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536336 35
  • 68.15 (n)
  • 71.13 (a)
NIM1K (1 of 3) 36
  • 68 (a)
OneToMany
NIM1K (2 of 3) 36
  • 55 (a)
OneToMany
NIM1K (3 of 3) 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4629 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F49C5.4 35
  • 53.8 (n)
  • 47.15 (a)
F49C5.4 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIN4 36
  • 10 (a)
ManyToMany
HSL1 36
  • 8 (a)
ManyToMany
KCC4 36
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for NIM1K:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIM1K Gene

ENSEMBL:
Gene Tree for NIM1K (if available)
TreeFam:
Gene Tree for NIM1K (if available)

Paralogs for NIM1K Gene

Paralogs for NIM1K Gene

Selected SIMAP similar genes for NIM1K Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NIM1K: view

Variants for NIM1K Gene

Sequence variations from dbSNP and Humsavar for NIM1K Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs782972 -- 43,191,393(+) AACTA(C/T)GACTT upstream-variant-2KB
rs782973 -- 43,194,611(+) GCAAG(C/T)AGTGG intron-variant
rs782974 -- 43,195,499(+) taaaa(A/T)ttttt intron-variant
rs782991 -- 43,221,976(-) catcc(A/G)tttat intron-variant
rs782992 -- 43,218,288(-) cacac(C/T)tgtaa intron-variant

Relevant External Links for NIM1K Gene

HapMap Linkage Disequilibrium report
NIM1K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NIM1K Gene

Disorders for NIM1K Gene

No disorders were found for NIM1K Gene.

No data available for UniProtKB/Swiss-Prot for NIM1K Gene

Publications for NIM1K Gene

  1. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PMID: 15733851) Jaleel M. … Alessi D.R. (FEBS Lett. 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for NIM1K Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NIM1K
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NIM1K
    • Block miRNA regulation of NIM1K using miScript Target Protectors

    Sources for NIM1K Gene

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