NIM1 Gene
protein-coding GIFtS: 36
GCID: GC05P043193
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NIM1
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Aliases
for NIM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| EC 2.7.11.13 8 | | Serine/Threonine-Protein Kinase NIM12 | | EC 2.7.118 |
Export aliases for NIM1 gene to outside databases |
Summaries
for NIM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NIM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NIM1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NIM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p12 Ensembl cytogenetic band: 5p12 NIM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P043193: view genomic region
(about GC identifiers)
Start:
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43,192,173 bp from pter |
End:
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43,280,952 bp from pter |
Size:
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88,780 bases |
Orientation:
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plus strand |
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Proteins
for NIM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NIM1_HUMAN, Q8IY84 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase NIM1 Size: 436 amino acids; 49606 Da
Cofactor: Magnesium
Secondary accessions: B3KVM1Explore the universe of human proteins at neXtProt for NIM1: NX_Q8IY84
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IY84
2 DME Specific Peptides for NIM1 (Q8IY84)
NIM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_699192.1
ENSEMBL proteins: ENSP00000313572 ENSP00000420849
Human Recombinant Protein Products for NIM1:
NIM1 Antibody Products:
Assay Products for NIM1: |
Protein
Domains /
Families
for NIM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NIM1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IY84ProtoNet protein and cluster: Q8IY84 UniProtKB/Swiss-Prot: NIM1_HUMAN, Q8IY84Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for NIM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NIM1_HUMAN, Q8IY84Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation at Thr-229, probably by autophosphorylation Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NIM1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for NIM1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIM1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIM1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for NIM1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NIM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIM1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIM1 |
|
Pathways & Interactions
for NIM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NIM1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
NIM1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NIM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NIM1
1 HMDB Compound for NIM1 About this table
Search CenterWatch for drugs/clinical trials and news about NIM1
|
Transcripts
for NIM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NIM1 gene: NM_153361.3 Unigene Cluster for NIM1: Serine/threonine-protein kinase NIM1 Hs.25845 [show with all ESTs]Unigene Representative Sequence: NR_0729805 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000509362 ENST00000326035(uc003jno.3) ENST00000513797 ENST00000440285
ENST00000512796
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIM1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIM1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for NIM1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NIM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIM1 |
Additional cDNA sequence: AK122985.1 BC036422.2 NR_072980.1 3 DOTS entries: DT.410121 DT.101965504 DT.100744887 24/28 AceView cDNA sequences (see all 28): AI335850 AK122985 BQ447856 BE551926 AW138655 BG709047 BC036422 CB995976 NM_153361 BQ673362 BM686574 BX112667 BU727953 AI609751 CB990247 BQ635881 AW138653 CB997450 AI949037 BF222940 AA912775 R59486 R53564 R54269
GeneLoc Exon Structure
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Expression
for NIM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NIM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCTACCAG
About this image
See NIM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NIM1
SOURCE GeneReport for Unigene cluster: Hs.25845
SABiosciences Custom PCR Arrays for NIM1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIM1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NIM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIM1 |
Orthologs
for NIM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NIM1 gene from 6/24 species (see all 24) About this table
ENSEMBL Gene Tree for NIM1 (if available)
TreeFam Gene Tree for NIM1 (if available) |
Paralogs
for NIM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NIM1 gene
- BRSK12 NUAK12 MARK12 BRSK22 SIK32 SNRK2 SIK22 NUAK22
- MARK22 SIK12 MARK42 MARK32
18/24 SIMAP similar genes for NIM1 using alignment to 1 protein entry: NIM1_HUMAN(see all similar genes):MARK2 Par1b KIAA0999 SIK1 SIK3 PRKAA1
MARK3 MARK1 PNCK PRKAA2 BRSK2 CAMK1
CAMK1D MELK PRKY SNRK TSSK6 TSSK2
NIM1 for paralogs About GeneDecksing
|
Genomic Variants
for NIM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NIM1 (43192173 - 43280952 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NIM1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIM1 |
|
Disorders
/ Diseases
for NIM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NIM1 for disorders About GeneDecksing
6  diseases for NIM1: About MalaCardspapillary adenocarcinoma thyroid carcinoma thyroiditis adenocarcinoma
carcinoma malaria
1 disease from the University of Copenhagen DISEASES database for NIM1:Papillary adenocarcinoma Export disorders for NIM1 gene to outside databases
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Publications
for NIM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NIM1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NIM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PubMed id 15733851)1, 2 Jaleel M....Alessi D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NIM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NIM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing NIM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NIM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for NIM1 gene:
Search GeneIP for patents involving NIM1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NIM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NIM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NIM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NIM1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NIM1 | | OriGene 3'-UTR Clone for NIM1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NIM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NIM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NIM1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NIM1 | | OriGene Custom Protein Services for NIM1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NIM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NIM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NIM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NIM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NIM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NIM1 |
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| | | | Search Tocris compounds for NIM1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NIM1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for NIM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NIM1 |
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