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NIFK Gene

protein-coding   GIFtS: 45
GCID: GC02M122485

Nucleolar Protein Interacting With The FHA Domain Of MKI67

(Previous name: MKI67 (FHA domain) interacting nucleolar phosphoprotein)
(Previous symbol: MKI67IP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleolar Protein Interacting With The FHA Domain Of MKI671 2     hNIFK2 3
MKI67IP1 2 3 5     NOPP343 5
Nucleolar Protein Interacting With The FHA Domain Of PKI-671 2 3     Nopp342
MKI67 (FHA Domain) Interacting Nucleolar Phosphoprotein1 2     MKI67 FHA Domain-Interacting Nucleolar Phosphoprotein2
Nucleolar Phosphoprotein Nopp342 3     

External Ids:    HGNC: 178381   Entrez Gene: 843652   Ensembl: ENSG000001554387   OMIM: 6119705   UniProtKB: Q9BYG33   

Export aliases for NIFK gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NIFK Gene:
This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded
protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on
chromosomes 5, 10, 12, 15, and 19.(provided by RefSeq, Jan 2009)

GeneCards Summary for NIFK Gene:
NIFK (nucleolar protein interacting with the FHA domain of MKI67) is a protein-coding gene.

Gene Wiki entry for NIFK (MKI67IP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NIFK
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNIFK promoter sequence
   Search Chromatin IP Primers for NIFK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NIFK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.3   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q14.3

NIFK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NIFK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M122485:  view genomic region     (about GC identifiers)

Start:
122,484,521 bp from pter      End:
122,494,503 bp from pter
Size:
9,983 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MK67I_HUMAN, Q9BYG3 (See protein sequence)
Recommended Name: MKI67 FHA domain-interacting nucleolar phosphoprotein  
Size: 293 amino acids; 34222 Da
Subunit: Binds to the FHA domain of MKI67; this interaction is enhanced in mitosis
1 PDB 3D structure from and Proteopedia for NIFK:
2AFF (3D)    
Secondary accessions: A8K788 Q8TB66 Q96ED4

Explore the universe of human proteins at neXtProt for NIFK: NX_Q9BYG3

Explore proteomics data for NIFK at MOPED

Post-translational modifications: 

  • Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 is
    phosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated.
    Phosphorylation enhances MKI67 binding1
  • Ubiquitination2 at Lys139
  • Modification sites at PhosphoSitePlus

  • See NIFK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115766.3  
    ENSEMBL proteins: 
     ENSP00000285814   ENSP00000390174   ENSP00000406227   ENSP00000398116  

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for NIFK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR021043 hNIFK_FHA_Ki67_binding

    Graphical View of Domain Structure for InterPro Entry Q9BYG3

    ProtoNet protein and cluster: Q9BYG3

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: MK67I_HUMAN, Q9BYG3
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with NIFK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA11342549
    GO:0005515protein binding IPI11342549
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NIFK           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NIFK:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NIFK
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    hsa-mir-30a-5p (MIRT028519), hsa-mir-1 (MIRT023680)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MK67I_HUMAN, Q9BYG3: Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with
    MKI67

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000794condensed nuclear chromosome IDA11342549
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA11342549
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA11342549

    Find genes that share ontologies with NIFK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NIFK
    Interactions:

        Search GeneGlobe Interaction Network for NIFK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NIFK (Q9BYG32, 3 ENSP000002858144) via UniProtKB, MINT, STRING, and/or I2D (see all 419)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MKI67P460132, 3, ENSP000003576434MINT-50550 I2D: score=2 STRING: ENSP00000357643
    GABARAPO951663I2D: score=1 
    PDCD11ENSP000003588124STRING: ENSP00000358812
    GTPBP4ENSP000003540404STRING: ENSP00000354040
    BRIX1ENSP000003388624STRING: ENSP00000338862
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly NAS11342549
    GO:0009303rRNA transcription NAS11342549
    GO:0010923negative regulation of phosphatase activity IDA19389623
    GO:0016072rRNA metabolic process NAS11342549

    Find genes that share ontologies with NIFK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NIFK (MK67I)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NIFK gene: 
    NM_032390.4  

    Unigene Cluster for NIFK:

    MKI67 (FHA domain) interacting nucleolar phosphoprotein
    Hs.367842  [show with all ESTs]
    Unigene Representative Sequence: NM_032390
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285814(uc002tnk.3) ENST00000423105 ENST00000481978 ENST00000498570
    ENST00000447132 ENST00000451734 ENST00000477693(uc010fls.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NIFK
      QuantiFast Probe-based Assays in human, mouse, rat NIFK

    Additional mRNA sequence: 

    AB044971.1 AK027097.1 AK291903.1 AK299814.1 AK311033.1 BC012457.1 BC022990.1 BC024238.2 

    10 DOTS entries:

    DT.416793  DT.97845050  DT.92450601  DT.97778505  DT.121000388  DT.97804207  DT.100028979  DT.100733042 
    DT.92450605  DT.99995751 

    Selected AceView cDNA sequences (see all 350):

    BE886127 W57770 AI538201 CR594765 AI420503 CB121085 CR598208 AI217616 
    BM974502 AI761913 AA974026 AI221465 AI247542 BE042711 AA456437 BM128591 
    AI668969 BI769250 BP336789 BU173145 BI757013 AI051540 CA867830 AU185227 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NIFK    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:        -                                                         
    SP2:                                                                  
    SP3:                                      -                           


    ECgene alternative splicing isoforms for NIFK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NIFK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NIFK Expression
    About this image

    NIFK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NIFK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367842
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NIFK gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mki67ip5
    Nifk1
    Mki67 (FHA domain) interacting nucleolar phosphoprotein5
    nucleolar protein interacting with the FHA domain of more1
    70.02(n)1
    62.85(a)1
      1 (52.14 cM)5
    679491  NM_026472.41  NP_080748.31 
     1183218395 
    chicken
    (Gallus gallus)
    Aves MKI67IP1 MKI67 (FHA domain) interacting nucleolar phosphoprotein 60.19(n)
    56.75(a)
      424239  XM_422088.3  XP_422088.1 
    lizard
    (Anolis carolinensis)
    Reptilia NIFK6
    nucleolar protein interacting with the FHA domain ...
    53(a)
    1 ↔ 1
    3(2135298-2142996)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986452 hypothetical protein LOC398645 76.41(n)    BC054288.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mki67ipl2 mki67 (FHA domain) interacting nucleolar phosphoprotein more 79.12(n)   317644  AF506200.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69376
    --
    22(a)
    1 ↔ 1
    3R(18410508-18411931)
    worm
    (Caenorhabditis elegans)
    Secernentea T04A8.66
    Protein T04A8.6 (T04A8.6) mRNA, complete cds
    25(a)
    1 ↔ 1
    III(4692092-4693299) WBGene00011408
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOP15(YNL110C)4 Constituent of 66S pre-ribosomal particles, involved more   --   14(418488-417826) 855613  NP_014289.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G046001 AT5G04600 48.15(n)
    38.89(a)
      830337  NM_120542.4  NP_196080.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g04122001 Os08g0412200 51.37(n)
    41.1(a)
      4345558  NM_001068328.1  NP_001061793.1 


    ENSEMBL Gene Tree for NIFK (if available)
    TreeFam Gene Tree for NIFK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NIFK gene

    Find genes that share paralogs with NIFK           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for NIFK (see all 12)
    PGOHUM00000238710 PGOHUM00000239307 PGOHUM00000246855 PGOHUM00000246910 PGOHUM00000246911


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NIFK (see all 305)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447553821,2
    C--122486733(+) GAGTTC/TGAGAC 1 -- int10--------
    rs1818982851,2
    --122486764(+) TGAAAA/CCCTAT 1 -- int10--------
    rs1117888201,2
    C,F--122486811(+) GGTGGC/TGTGTG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1115689881,2
    C,F--122486815(+) GTGTGG/TGCCTG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs75654981,2
    C--122486825(+) gtagtA/Cccagc 1 -- int10--------
    rs1896901431,2
    --122486858(+) AGAATC/TGCTTG 1 -- int10--------
    rs753639981,2
    C--122486962(+) AAAAAA/GAAAAG 1 -- int10--------
    rs1823208311,2
    --122487005(+) AATAAC/GCTTCA 1 -- int10--------
    rs1506540311,2
    --122487079(+) TTTTGC/GTATCT 1 -- int10--------
    rs1388115491,2
    --122487093(+) TATAGC/GATACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NIFK (122484521 - 122494503 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NIFK: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NIFK
    DNA2.0 Custom Variant and Variant Library Synthesis for NIFK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611970    OMIM disorders: --


    Find genes that share disorders with NIFK           About GenesLikeMe


    Export disorders for NIFK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NIFK gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with NIFK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. (PubMed id 11342549)1, 2, 3, 9 Takagi M.... Yoneda Y. (J. Biol. Chem. 2001)
    2. Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. (PubMed id 16244663)1, 2, 3 Byeon I.-J.... Tsai M.-D. (Nat. Struct. Mol. Biol. 2005)
    3. Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. (PubMed id 14659764)1, 2, 3 Li H.... Tsai M.-D. (J. Mol. Biol. 2004)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84365 HGNC: 17838 AceView: MKI67IP Ensembl:ENSG00000155438 euGenes: HUgn84365
    ECgene: NIFK H-InvDB: NIFK

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NIFK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NIFK gene:
    Search GeneIP for patents involving NIFK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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