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Aliases for NIFK Gene

Aliases for NIFK Gene

  • Nucleolar Protein Interacting With The FHA Domain Of MKI67 2 3 5
  • Nucleolar Protein Interacting With The FHA Domain Of PKi-67 2 3 4
  • Nucleolar Phosphoprotein Nopp34 3 4
  • MKI67IP 3 4
  • Nopp34 3 4
  • HNIFK 3 4
  • MKI67 (FHA Domain) Interacting Nucleolar Phosphoprotein 2
  • MKI67 FHA Domain-Interacting Nucleolar Phosphoprotein 3

External Ids for NIFK Gene

Previous HGNC Symbols for NIFK Gene

  • MKI67IP

Previous GeneCards Identifiers for NIFK Gene

  • GC02M122485

Summaries for NIFK Gene

Entrez Gene Summary for NIFK Gene

  • This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]

GeneCards Summary for NIFK Gene

NIFK (Nucleolar Protein Interacting With The FHA Domain Of MKI67) is a Protein Coding gene. Diseases associated with NIFK include Megaloblastic Anemia-1, Finnish Type. GO annotations related to this gene include nucleic acid binding and RNA binding.

Gene Wiki entry for NIFK Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIFK Gene

Genomics for NIFK Gene

Regulatory Elements for NIFK Gene

Enhancers for NIFK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F120892 1.4 Ensembl ENCODE 27.1 +843.1 843052 3.0 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 NIFK TSN GLI2 ENSG00000271709 ENSG00000201584 GC02M121041
GH02F121735 1.1 ENCODE 16.1 -0.2 -179 3.9 HDGF ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 SLC30A9 NIFK LINC01823 TSN ENSG00000270798
GH02F121647 1.1 ENCODE 15.5 +86.9 86931 5.1 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 NIFK TSN LINC01823 CLASP1 NIFK-AS1 GC02M121659
GH02F121524 1.4 Ensembl ENCODE 10.6 +207.9 207888 9.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 TSN NIFK LINC01823 CLASP1 ENSG00000265451 GC02M121346
GH02F121706 1.1 Ensembl ENCODE 11.8 +28.9 28943 2.5 ELF3 INSM2 ARID4B FEZF1 RARA SLC30A9 ZNF366 THAP11 HMG20B OVOL3 NIFK TSN NPM1P32 ENSG00000279721
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NIFK on UCSC Golden Path with GeneCards custom track

Promoters for NIFK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000597713 327 2401 HDGF ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 SLC30A9

Genomic Location for NIFK Gene

Chromosome:
2
Start:
121,726,945 bp from pter
End:
121,736,927 bp from pter
Size:
9,983 bases
Orientation:
Minus strand

Genomic View for NIFK Gene

Genes around NIFK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIFK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIFK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIFK Gene

Proteins for NIFK Gene

  • Protein details for NIFK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG3-MK67I_HUMAN
    Recommended name:
    MKI67 FHA domain-interacting nucleolar phosphoprotein
    Protein Accession:
    Q9BYG3
    Secondary Accessions:
    • A8K788
    • Q8TB66
    • Q96ED4

    Protein attributes for NIFK Gene

    Size:
    293 amino acids
    Molecular mass:
    34222 Da
    Quaternary structure:
    • Binds to the FHA domain of MKI67; this interaction is enhanced in mitosis.

    Three dimensional structures from OCA and Proteopedia for NIFK Gene

neXtProt entry for NIFK Gene

Post-translational modifications for NIFK Gene

  • Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 is phosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated. Phosphorylation enhances MKI67 binding.
  • Ubiquitination at Lys 139
  • Modification sites at PhosphoSitePlus

Other Protein References for NIFK Gene

No data available for DME Specific Peptides for NIFK Gene

Domains & Families for NIFK Gene

Gene Families for NIFK Gene

Suggested Antigen Peptide Sequences for NIFK Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYG3

UniProtKB/Swiss-Prot:

MK67I_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with NIFK: view

Function for NIFK Gene

Gene Ontology (GO) - Molecular Function for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 11342549
GO:0005515 protein binding IPI 11342549
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NIFK: view
genes like me logo Genes that share phenotypes with NIFK: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NIFK Gene

Localization for NIFK Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIFK Gene

Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NIFK gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IDA 11342549
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 11342549
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA 11342549
genes like me logo Genes that share ontologies with NIFK: view

Pathways & Interactions for NIFK Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 11342549
GO:0009303 rRNA transcription NAS 11342549
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0016072 rRNA metabolic process NAS 11342549
genes like me logo Genes that share ontologies with NIFK: view

No data available for Pathways by source and SIGNOR curated interactions for NIFK Gene

Transcripts for NIFK Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIFK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -

Relevant External Links for NIFK Gene

GeneLoc Exon Structure for
NIFK
ECgene alternative splicing isoforms for
NIFK

Expression for NIFK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NIFK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NIFK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.3) and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NIFK Gene



Protein tissue co-expression partners for NIFK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NIFK Gene:

NIFK
genes like me logo Genes that share expression patterns with NIFK: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NIFK Gene

Orthologs for NIFK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIFK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MKI67IP 35 34
  • 99.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NIFK 34
  • 82.82 (n)
MKI67IP 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MKI67IP 34
  • 82.37 (n)
NIFK 35
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nifk 34
  • 72.45 (n)
mouse
(Mus musculus)
Mammalia Nifk 34 16
  • 70.02 (n)
Mki67ip 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NIFK 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves MKI67IP 34
  • 60.19 (n)
NIFK 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIFK 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nifk 34
  • 57.98 (n)
Str.1406 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398645 34
zebrafish
(Danio rerio)
Actinopterygii nifk 34 35
  • 60.66 (n)
mki67ipl 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11192 34
fruit fly
(Drosophila melanogaster)
Insecta CG6937 35
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T04A8.6 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP15 35 37
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G04600 34
  • 48.15 (n)
rice
(Oryza sativa)
Liliopsida Os08g0412200 34
  • 51.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10558 35
  • 29 (a)
OneToOne
Species where no ortholog for NIFK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIFK Gene

ENSEMBL:
Gene Tree for NIFK (if available)
TreeFam:
Gene Tree for NIFK (if available)

Paralogs for NIFK Gene

No data available for Paralogs for NIFK Gene

Variants for NIFK Gene

Sequence variations from dbSNP and Humsavar for NIFK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10189615 -- 121,734,427(+) Catat(A/G)tacat intron-variant
rs1056006 -- 121,727,530(-) TACCA(G/T)CTTGC intron-variant, utr-variant-3-prime
rs1056014 -- 121,727,400(-) CTAAA(C/T)TGCAG intron-variant, utr-variant-3-prime
rs111246690 -- 121,728,330(+) CCTGA(A/C)ACTTT nc-transcript-variant, reference, synonymous-codon
rs111289689 -- 121,735,486(+) CTAAA(C/T)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NIFK Gene

Variant ID Type Subtype PubMed ID
nsv961503 CNV duplication 23825009
nsv834351 CNV loss 17160897
nsv582808 CNV gain 21841781
nsv459163 CNV gain 19166990
nsv1011665 CNV gain 25217958
esv3592217 CNV gain 21293372
esv3592209 CNV gain 21293372

Variation tolerance for NIFK Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NIFK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NIFK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIFK Gene

Disorders for NIFK Gene

MalaCards: The human disease database

(1) MalaCards diseases for NIFK Gene - From: DISEASES

Disorder Aliases PubMed IDs
megaloblastic anemia-1, finnish type
  • megaloblastic anemia-1, norwegian type
- elite association - COSMIC cancer census association via MalaCards
Search NIFK in MalaCards View complete list of genes associated with diseases

Relevant External Links for NIFK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NIFK
genes like me logo Genes that share disorders with NIFK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NIFK Gene

Publications for NIFK Gene

  1. A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. (PMID: 11342549) Takagi M. … Yoneda Y. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. (PMID: 16244663) Byeon I.-J. … Tsai M.-D. (Nat. Struct. Mol. Biol. 2005) 2 3 4 64
  3. Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. (PMID: 14659764) Li H. … Tsai M.-D. (J. Mol. Biol. 2004) 2 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NIFK Gene

Sources for NIFK Gene

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