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Aliases for NIF3L1 Gene

Aliases for NIF3L1 Gene

  • NIF3 NGG1 Interacting Factor 3-Like 1 (S. Cerevisiae) 2 3
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 1 Protein 3 4
  • NIF3 (Ngg1 Interacting Factor 3, S.Pombe Homolog)-Like 1 2 3
  • ALS2CR1 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 1 3
  • NIF3 NGG1 Interacting Factor 3-Like 1 (S. Pombe) 2
  • Putative GTP Cyclohydrolase 1 Type 2 NIF3L1 3
  • GTP Cyclohydrolase I 3
  • NIF3-Like Protein 1 3
  • CALS-7 3
  • MDS015 3

External Ids for NIF3L1 Gene

Previous Symbols for NIF3L1 Gene

  • ALS2CR1

Summaries for NIF3L1 Gene

GeneCards Summary for NIF3L1 Gene

NIF3L1 (NIF3 NGG1 Interacting Factor 3-Like 1 (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with NIF3L1 include lateral sclerosis. GO annotations related to this gene include transcription factor binding.

UniProtKB/Swiss-Prot for NIF3L1 Gene

  • May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.

Gene Wiki entry for NIF3L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIF3L1 Gene

Genomics for NIF3L1 Gene

Genomic Location for NIF3L1 Gene

Start:
200,889,327 bp from pter
End:
200,903,932 bp from pter
Size:
14,606 bases
Orientation:
Plus strand

Genomic View for NIF3L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NIF3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIF3L1 Gene

Regulatory Elements for NIF3L1 Gene

Proteins for NIF3L1 Gene

  • Protein details for NIF3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZT8-GTPC1_HUMAN
    Recommended name:
    NIF3-like protein 1
    Protein Accession:
    Q9GZT8
    Secondary Accessions:
    • Q53TX4
    • Q6X735
    • Q9H2D2
    • Q9HC18

    Protein attributes for NIF3L1 Gene

    Size:
    377 amino acids
    Molecular mass:
    41968 Da
    Quaternary structure:
    • Homodimer (PubMed:12951069). Interacts with COPS2 (By similarity). Interacts with THOC7 (PubMed:12951069).
    SequenceCaution:
    • Sequence=AAG14952.1; Type=Frameshift; Positions=104, 109; Evidence={ECO:0000305};

    Alternative splice isoforms for NIF3L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NIF3L1 Gene

Proteomics data for NIF3L1 Gene at MOPED

Post-translational modifications for NIF3L1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys109, Lys216, Lys234, and Lys242

No data available for DME Specific Peptides for NIF3L1 Gene

Domains for NIF3L1 Gene

Protein Domains for NIF3L1 Gene

UniProtKB/Swiss-Prot:

GTPC1_HUMAN
Family:
  • Belongs to the GTP cyclohydrolase I type 2 family.:
    • Q9GZT8
genes like me logo Genes that share domains with NIF3L1: view

No data available for Gene Families for NIF3L1 Gene

Function for NIF3L1 Gene

Molecular function for NIF3L1 Gene

UniProtKB/Swiss-Prot Function: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.

Gene Ontology (GO) - Molecular Function for NIF3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003934 GTP cyclohydrolase I activity --
GO:0005515 protein binding IPI 12951069
GO:0005525 GTP binding IEA --
GO:0008134 transcription factor binding IPI 15163635
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NIF3L1: view

Phenotypes for NIF3L1 Gene

GenomeRNAi human phenotypes for NIF3L1:
genes like me logo Genes that share phenotypes with NIF3L1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NIF3L1 Gene

Localization for NIF3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIF3L1 Gene

Cytoplasm. Nucleus. Note=Interaction with COPS2 may regulate localization to the nucleus. {ECO:0000250 UniProtKB:Q9EQ80}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NIF3L1 Gene COMPARTMENTS Subcellular localization image for NIF3L1 gene
Compartment Confidence
mitochondrion 3
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NIF3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA 12951069
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with NIF3L1: view

Pathways for NIF3L1 Gene

SuperPathways for NIF3L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIF3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030182 neuron differentiation ISS --
GO:0035998 7,8-dihydroneopterin 3-triphosphate biosynthetic process IEA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 15163635
GO:1903507 negative regulation of nucleic acid-templated transcription ISS --
genes like me logo Genes that share ontologies with NIF3L1: view

No data available for Pathways by source for NIF3L1 Gene

Transcripts for NIF3L1 Gene

Unigene Clusters for NIF3L1 Gene

NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NIF3L1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - -
SP2:
SP3:
SP4: -
SP5: - - - -
SP6: -
SP7: -

Relevant External Links for NIF3L1 Gene

GeneLoc Exon Structure for
NIF3L1
ECgene alternative splicing isoforms for
NIF3L1

Expression for NIF3L1 Gene

mRNA expression in normal human tissues for NIF3L1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NIF3L1 Gene

SOURCE GeneReport for Unigene cluster for NIF3L1 Gene Hs.145284

genes like me logo Genes that share expressions with NIF3L1: view

Orthologs for NIF3L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NIF3L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NIF3L1 36
  • 99.47 (n)
  • 99.47 (a)
NIF3L1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NIF3L1 36
  • 88.51 (n)
  • 88.06 (a)
NIF3L1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NIF3L1 36
  • 88.77 (n)
  • 87.8 (a)
NIF3L1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nif3l1 36
  • 85.73 (n)
  • 84.57 (a)
Nif3l1 16
Nif3l1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NIF3L1 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIF3L1 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nif3l1 36
  • 85.83 (n)
  • 86.76 (a)
chicken
(Gallus gallus)
Aves NIF3L1 36
  • 71 (n)
  • 71.75 (a)
NIF3L1 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIF3L1 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733905 36
  • 60.8 (n)
  • 54.14 (a)
Str.4241 36
zebrafish
(Danio rerio)
Actinopterygii nif3l1 36
  • 54.94 (n)
  • 49.13 (a)
nif3l1 37
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012228 36
  • 50.81 (n)
  • 44.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4278 36
  • 48.99 (n)
  • 45.3 (a)
CG4278 37
  • 41 (a)
OneToOne
CG4278 38
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR233W 36
  • 47.89 (n)
  • 41.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIF3 36
  • 48.81 (n)
  • 40.59 (a)
NIF3 37
  • 34 (a)
OneToOne
NIF3 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01518g 36
  • 46.64 (n)
  • 40.26 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06108 36
  • 49.58 (n)
  • 41.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC126.12 36
  • 50.07 (n)
  • 45.81 (a)
Species with no ortholog for NIF3L1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NIF3L1 Gene

ENSEMBL:
Gene Tree for NIF3L1 (if available)
TreeFam:
Gene Tree for NIF3L1 (if available)

Paralogs for NIF3L1 Gene

Selected SIMAP similar genes for NIF3L1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for NIF3L1 Gene

genes like me logo Genes that share paralogs with NIF3L1: view

No data available for Paralogs for NIF3L1 Gene

Variants for NIF3L1 Gene

Sequence variations from dbSNP and Humsavar for NIF3L1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7917 - 200,903,515(-) CCAAA(A/G)TATCA reference, missense
rs1179238 -- 200,894,160(-) gtctc(A/T)ctctg intron-variant
rs2271273 -- 200,899,267(-) ACCAG(C/G/T)ATATG intron-variant
rs6435066 -- 200,901,300(+) tgtct(C/G)catag intron-variant
rs7584341 -- 200,901,383(+) tACTT(G/T)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NIF3L1 Gene

Variant ID Type Subtype PubMed ID
nsv3109 CNV Loss 18451855

Relevant External Links for NIF3L1 Gene

HapMap Linkage Disequilibrium report
NIF3L1

Disorders for NIF3L1 Gene

(1) MalaCards Diseases for NIF3L1 Gene

Search for NIF3L1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NIF3L1 Gene

Relevant External Links for NIF3L1

Genetic Association Database (GAD)
NIF3L1
Human Genome Epidemiology (HuGE) Navigator
NIF3L1
genes like me logo Genes that share disorders with NIF3L1: view

No data available for UniProtKB/Swiss-Prot for NIF3L1 Gene

Publications for NIF3L1 Gene

  1. Isolation and characterization of a novel human gene, NIF3L1, and its mouse ortholog, Nif3l1, highly conserved from bacteria to mammals. (PMID: 11124544) Tascou S. … Burfeind P. (Cytogenet. Cell Genet. 2000) 2 3 4 23
  2. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PMID: 11161814) Hadano S. … Hayden M.R. (Genomics 2001) 2 3 4
  3. The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2. (PMID: 12522100) Akiyama H. … Tashiro F. (J. Biol. Chem. 2003) 2 3
  4. Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. (PMID: 12951069) Tascou S. … Burfeind P. (Biochem. Biophys. Res. Commun. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for NIF3L1 Gene

Sources for NIF3L1 Gene

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