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Aliases for NID2 Gene

Aliases for NID2 Gene

  • Nidogen 2 (Osteonidogen) 2 3
  • Osteonidogen 3 4
  • NID-2 3 4
  • Nidogen-2 3

External Ids for NID2 Gene

Summaries for NID2 Gene

Entrez Gene Summary for NID2 Gene

  • This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]

GeneCards Summary for NID2 Gene

NID2 (Nidogen 2 (Osteonidogen)) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Non-integrin membrane-ECM interactions. GO annotations related to this gene include calcium ion binding and collagen binding. An important paralog of this gene is LRP1B.

UniProtKB/Swiss-Prot for NID2 Gene

  • Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions

Gene Wiki entry for NID2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NID2 Gene

Genomics for NID2 Gene

Genomic Location for NID2 Gene

Start:
52,004,802 bp from pter
End:
52,069,228 bp from pter
Size:
64,427 bases
Orientation:
Minus strand

Genomic View for NID2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NID2 Gene

Regulatory Elements for NID2 Gene

Proteins for NID2 Gene

  • Protein details for NID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14112-NID2_HUMAN
    Recommended name:
    Nidogen-2
    Protein Accession:
    Q14112
    Secondary Accessions:
    • A8K6I7
    • B4DU19
    • O43710

    Protein attributes for NID2 Gene

    Size:
    1375 amino acids
    Molecular mass:
    151254 Da
    Quaternary structure:
    • Interacts with LAMA2 (By similarity). Interacts with COL13A1.
    SequenceCaution:
    • Sequence=BAA13087.1; Type=Frameshift; Positions=54, 68, 150, 172; Evidence={ECO:0000305}; Sequence=BAA24112.1; Type=Frameshift; Positions=54, 68, 150, 172; Evidence={ECO:0000305};

    Alternative splice isoforms for NID2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NID2 Gene

Proteomics data for NID2 Gene at MOPED

Post-translational modifications for NID2 Gene

  • Highly N- and O-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser358, Ser359, Thr360, Thr365, Thr369, Ser370, Thr391, Ser393, Asn417, Ser448, Ser452, Thr455, Thr456, Ser459, Thr479, Asn658, Asn693, Asn703, and Asn1124

Other Protein References for NID2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NID2 Gene

Domains for NID2 Gene

Suggested Antigen Peptide Sequences for NID2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14112

UniProtKB/Swiss-Prot:

NID2_HUMAN
Domain:
  • Contains 5 EGF-like domains.:
    • Q14112
  • Contains 1 NIDO domain.:
    • Q14112
  • Contains 1 nidogen G2 beta-barrel domain.:
    • Q14112
  • Contains 2 thyroglobulin type-1 domains.:
    • Q14112
Similarity:
  • Contains 5 LDL-receptor class B repeats.:
    • Q14112
genes like me logo Genes that share domains with NID2: view

No data available for Gene Families for NID2 Gene

Function for NID2 Gene

Molecular function for NID2 Gene

UniProtKB/Swiss-Prot Function: Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions

Gene Ontology (GO) - Molecular Function for NID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 11956183
GO:0005518 collagen binding TAS 9733643
genes like me logo Genes that share ontologies with NID2: view

Phenotypes for NID2 Gene

MGI mutant phenotypes for NID2:
inferred from 1 alleles
GenomeRNAi human phenotypes for NID2:
genes like me logo Genes that share phenotypes with NID2: view

miRNA for NID2 Gene

miRTarBase miRNAs that target NID2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NID2 Gene

Localization for NID2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NID2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NID2 Gene COMPARTMENTS Subcellular localization image for NID2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix --
GO:0005604 basement membrane IDA 22952693
GO:0009986 cell surface IEA --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with NID2: view

Pathways for NID2 Gene

genes like me logo Genes that share pathways with NID2: view

Pathways by source for NID2 Gene

2 Reactome pathways for NID2 Gene

Gene Ontology (GO) - Biological Process for NID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9733643
GO:0007160 cell-matrix adhesion IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0071711 basement membrane organization TAS 22952693
genes like me logo Genes that share ontologies with NID2: view

Transcripts for NID2 Gene

Unigene Clusters for NID2 Gene

Nidogen 2 (osteonidogen):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NID2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^
SP1: - - - -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:

ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b ^ 22
SP1: - -
SP2:
SP3:
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for NID2 Gene

GeneLoc Exon Structure for
NID2
ECgene alternative splicing isoforms for
NID2

Expression for NID2 Gene

mRNA expression in normal human tissues for NID2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NID2 Gene

SOURCE GeneReport for Unigene cluster for NID2 Gene Hs.369840

mRNA Expression by UniProt/SwissProt for NID2 Gene

Q14112-NID2_HUMAN
Tissue specificity: Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle
genes like me logo Genes that share expressions with NID2: view

No data available for mRNA differential expression in normal tissues for NID2 Gene

Orthologs for NID2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NID2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NID2 35
  • 99.35 (n)
  • 99.1 (a)
NID2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NID2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NID2 35
  • 86.81 (n)
  • 84.16 (a)
NID2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nid2 35
  • 82.76 (n)
  • 82.07 (a)
Nid2 16
Nid2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NID2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NID2 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nid2 35
  • 81.9 (n)
  • 80.63 (a)
chicken
(Gallus gallus)
Aves NID2 35
  • 67.29 (n)
  • 67.08 (a)
NID2 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NID2 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8084 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nid2 35
  • 58.46 (n)
  • 53.94 (a)
Str.6011 35
zebrafish
(Danio rerio)
Actinopterygii nid2 35
nid2a 35
  • 58.06 (n)
  • 54.79 (a)
nid2a 36
  • 44 (a)
OneToMany
nid2b 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ndg 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nid-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3675 36
  • 35 (a)
OneToMany
Species with no ortholog for NID2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NID2 Gene

ENSEMBL:
Gene Tree for NID2 (if available)
TreeFam:
Gene Tree for NID2 (if available)

Paralogs for NID2 Gene

Paralogs for NID2 Gene

Selected SIMAP similar genes for NID2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NID2: view

Variants for NID2 Gene

Sequence variations from dbSNP and Humsavar for NID2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs730531 -- 52,051,965(-) TGCTT(C/T)GGGCT intron-variant
rs730532 -- 52,052,093(-) AAAGA(C/T)GCATT intron-variant
rs739321 -- 52,061,255(-) TCTAT(A/G)GGGAA intron-variant
rs753050 -- 52,038,657(-) CCTAG(C/T)GCCAT intron-variant
rs753051 -- 52,038,642(-) TGTTA(C/T)GTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NID2 Gene

Variant ID Type Subtype PubMed ID
nsv901947 CNV Gain 21882294
nsv85620 CNV Insertion 16902084
nsv901948 CNV Gain 21882294

Relevant External Links for NID2 Gene

HapMap Linkage Disequilibrium report
NID2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NID2 Gene

Disorders for NID2 Gene

Relevant External Links for NID2

Genetic Association Database (GAD)
NID2
genes like me logo Genes that share disorders with NID2: view

No data available for UniProtKB/Swiss-Prot for NID2 Gene

Publications for NID2 Gene

  1. Nidogen-2: a new basement membrane protein with diverse binding properties. (PMID: 9733643) Kohfeldt E. … Timpl R. (J. Mol. Biol. 1998) 2 3 4
  2. The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin. (PMID: 11956183) Tu H. … Pihlajaniemi T. (J. Biol. Chem. 2002) 3 4
  3. Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer. (PMID: 17328794) Ulazzi L. … Negrini M. (Mol. Cancer 2007) 3 23
  4. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PMID: 17903307) Wilk J.B. … O'Connor G.T. (BMC Med. Genet. 2007) 3 48
  5. Nidogen-2: a new serum biomarker for ovarian cancer. (PMID: 19883638) Kuk C. … Diamandis E.P. (Clin. Biochem. 2010) 3

Products for NID2 Gene

Sources for NID2 Gene

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