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NID2 Gene

protein-coding   GIFtS: 61
GCID: GC14M052471

Nidogen 2 (Osteonidogen)

  Search for NID2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nidogen 2 (Osteonidogen)1 2
NID-22 3
nidogen-22
osteonidogen2
Osteonidogen3

External Ids:    HGNC: 133891   Entrez Gene: 227952   Ensembl: ENSG000000873037   OMIM: 6053995   UniProtKB: Q141123   

Export aliases for NID2 gene to outside databases

Previous GC identifers: GC14M049794 GC14M046267 GC14M050461 GC14M051541 GC14M032632


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NID2 Gene:
This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion
protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the
basement membrane.(provided by RefSeq, Jun 2010)

GeneCards Summary for NID2 Gene:
NID2 (nidogen 2 (osteonidogen)) is a protein-coding gene. GO annotations related to this gene include collagen binding and calcium ion binding. An important paralog of this gene is LRP6.

UniProtKB/Swiss-Prot: NID2_HUMAN, Q14112
Function: Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and
IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix
interactions

Gene Wiki entry for NID2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NID2 gene promoter:
         Oct-B1   E2F-4   E2F-3a   E2F-5   oct-B3   oct-B2   E2F-2   E2F-1   E2F   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNID2 promoter sequence
   Search Chromatin IP Primers for NID2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NID2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

NID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NID2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M052471:  view genomic region     (about GC identifiers)

Start:
52,471,520 bp from pter      End:
52,535,946 bp from pter
Size:
64,427 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NID2_HUMAN, Q14112 (See protein sequence)
Recommended Name: Nidogen-2 precursor  
Size: 1375 amino acids; 151254 Da
Subunit: Interacts with LAMA2 (By similarity). Interacts with COL13A1
Sequence caution: Sequence=BAA13087.1; Type=Frameshift; Positions=54, 68, 150, 172; Sequence=BAA24112.1;
Type=Frameshift; Positions=54, 68, 150, 172;
Secondary accessions: A8K6I7 B4DU19 O43710
Alternative splicing: 2 isoforms:  Q14112-1   Q14112-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NID2: NX_Q14112

Explore proteomics data for NID2 at MOPED

Post-translational modifications: 

  • Highly N- and O-glycosylated1
  • Glycosylation2 at Ser358, Ser359, Thr360, Thr365, Thr369, Ser370, Thr391, Ser393, Asn417, Ser448,
                                 Ser452, Thr455, Thr456, Ser459, Thr479, Asn658, Asn693, Asn703, Asn1124
  • Modification sites at PhosphoSitePlus

  • See NID2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031387.3  
    ENSEMBL proteins: 
     ENSP00000216286   ENSP00000452190   ENSP00000443730  
    Reactome Protein details: Q14112

    NID2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NID2
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    Novus Biologicals NID2 Proteins
    Novus Biologicals NID2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NID2

     
    Search eBioscience for Proteins for NID2 

    NID2 Antibody Products:

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    Search eBioscience for ELISAs for NID2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 15):
     IPR000033 LDLR_classB_rpt
     IPR000742 EG-like_dom
     IPR000716 Thyroglobulin_1
     IPR009017 GFP
     IPR026823 cEGF

    Graphical View of Domain Structure for InterPro Entry Q14112

    ProtoNet protein and cluster: Q14112

    Selected Blocks protein domains (see all 6):
    IPB000033 Low-density lipoprotein receptor
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000716 Thyroglobulin type-1
    IPB001881 EGF-like calcium-binding
    IPB003886 Nidogen


    UniProtKB/Swiss-Prot: NID2_HUMAN, Q14112
    Similarity: Contains 5 EGF-like domains
    Similarity: Contains 5 LDL-receptor class B repeats
    Similarity: Contains 1 NIDO domain
    Similarity: Contains 1 nidogen G2 beta-barrel domain
    Similarity: Contains 2 thyroglobulin type-1 domains


    Find genes that share domains with NID2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NID2_HUMAN, Q14112
    Function: Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and
    IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix
    interactions

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI11956183
    GO:0005518collagen binding TAS9733643
         
    Find genes that share ontologies with NID2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NID2:
     Decreased viability 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nid2):
     cellular  normal 

    Find genes that share phenotypes with NID2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NID2
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    miRNA
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    miRTarBase miRNAs that target NID2:
    hsa-mir-181d-5p (MIRT041174), hsa-mir-124-3p (MIRT022756), hsa-let-7a-5p (MIRT052404)

    Block miRNA regulation of human, mouse, rat NID2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NID2 (see all 22):
    hsa-miR-199b-3p hsa-let-7d hsa-miR-199a-3p hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-3129-5p hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidNID2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NID2
    Predesigned siRNA for gene silencing in human, mouse, rat NID2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NID2 (NM_007361)
    Sino Biological Human cDNA Clone for NID2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NID2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NID2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NID2

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13177) for NID2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NID2_HUMAN, Q14112: Secreted, extracellular space, extracellular matrix, basement membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IDA--
    GO:0009986cell surface IEA--
    GO:0031012colocalizes with extracellular matrix ISS--

    Find genes that share ontologies with NID2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NID2 About    
    See pathways by source

    SuperPathContained pathways About
    1Non-integrin membrane-ECM interactions
    Laminin interactions0.35
    2Degradation of the extracellular matrix
    Extracellular matrix organization0.34


    Find genes that share SuperPaths with NID2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NID2
        Laminin interactions


        Pathway & Disease-focused RT2 Profiler PCR Array including NID2: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NID2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for NID2 (Q141122, 3 ENSP000002162864) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61686 I2D: score=3 
    HSPG2P981603, ENSP000003638274I2D: score=3 STRING: ENSP00000363827
    LAMC1P110473, ENSP000002583414I2D: score=3 STRING: ENSP00000258341
    COL1A1P024523, ENSP000002259644I2D: score=1 STRING: ENSP00000225964
    FBLN2P980953, ENSP000003841694I2D: score=1 STRING: ENSP00000384169
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS9733643
    GO:0007160cell-matrix adhesion IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0071711basement membrane organization TAS--

    Find genes that share ontologies with NID2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NID2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NID2 gene: 
    NM_007361.3  

    Unigene Cluster for NID2:

    Nidogen 2 (osteonidogen)
    Hs.369840  [show with all ESTs]
    Unigene Representative Sequence: NM_007361
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216286(uc001wzo.3 uc010tqs.2 uc010tqt.1 uc001wzp.3)
    ENST00000556686 ENST00000555310 ENST00000556572 ENST00000553297 ENST00000557051
    ENST00000554284 ENST00000541773
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NID2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NID2 (see all 22):
    hsa-miR-199b-3p hsa-let-7d hsa-miR-199a-3p hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-3129-5p hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidNID2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NID2
    Clone
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    OriGene clones in human, mouse for NID2 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NID2 (NM_007361)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NID2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NID2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NID2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NID2
      QuantiTect SYBR Green Assays in human, mouse, rat NID2
      QuantiFast Probe-based Assays in human, mouse, rat NID2
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13177) for NID2 

    Additional mRNA sequence: 

    AJ223500.1 AK291652.1 AK298542.1 AK300462.1 BC035608.1 D86425.1 

    15 DOTS entries:

    DT.92424619  DT.102834395  DT.102834399  DT.315583  DT.91731826  DT.102834397  DT.91807905  DT.99927789 
    DT.120759531  DT.120759544  DT.91942186  DT.91944120  DT.95097582  DT.95266308  DT.120759563 

    Selected AceView cDNA sequences (see all 137):

    C01906 AV659395 AW664140 BX500200 AI655040 BX112956 AA112244 CB269743 
    AI864093 CA415339 AL603185 NM_007361 AI370580 BG424268 BM719690 D86425 
    AL704099 CF786060 CF455437 BQ926502 BQ008196 AI572102 CD172174 AI679086 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NID2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^
    SP1:                          -                                                     -           -                                               -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                              -     -                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b ^ 22
    SP1:  -                       -                     
    SP2:                                                
    SP3:                                                
    SP4:                          -           -         
    SP5:  -                                             


    ECgene alternative splicing isoforms for NID2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NID2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATCAATAT
    NID2 Expression
    About this image


    NID2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    NID2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NID2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369840

    UniProtKB/Swiss-Prot: NID2_HUMAN, Q14112
    Tissue specificity: Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including NID2: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NID2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NID2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NID2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nid21 , 5 nidogen 21, 5 82.76(n)1
    82.07(a)1
      14 (10.73 cM)5
    180741  NM_008695.21  NP_032721.21 
     197512575 
    chicken
    (Gallus gallus)
    Aves NID21 nidogen 2 (osteonidogen) 67.29(n)
    67.08(a)
      423583  XM_421471.4  XP_421471.4 
    lizard
    (Anolis carolinensis)
    Reptilia NID26
    nidogen 2 (osteonidogen)
    65(a)
    1 ↔ 1
    GL343501.1(477265-564142)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80842 Xenopus laevis transcribed sequence with moderate similarity more 75.29(n)    CF283341.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nid22 nidogen 2 (osteonidogen) 73.33(n)   373088  AY193826.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ndg6
    Nidogen/entactin
    27(a)
    1 → many
    2R(6201423-6209405)
    worm
    (Caenorhabditis elegans)
    Secernentea nid-16
    Protein NID-1, isoform a (nid-1) mRNA, complete cd...
    23(a)
    1 → many
    V(12910113-12917221) WBGene00003738


    ENSEMBL Gene Tree for NID2 (if available)
    TreeFam Gene Tree for NID2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NID2 gene
    LRP62  LRP52  LRP22  LRP1B2  EGF2  LDLR2  LRP5L2  LRP42  
    VLDLR2  NID12  LRP82  LRP12  
    8 SIMAP similar genes for NID2 using alignment to 4 protein entries:     NID2_HUMAN (see all proteins):
    DKFZp686D12108    NID1    LRP1    LDLR    LRP5L    NELL2
    FBLN2    PROS1

    Find genes that share paralogs with NID2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NID2 (see all 1969)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358364
    A breast cancer sample4--see VAR_0358362 P S mis40--------
    rs1510328331,2
    Cuntested152520480(+) GTTTTC/TGGGGT 2 K E mis11Minor allele frequency- T:0.00NA 4550
    rs128962611,2
    C,F--52471937(+) ATGTTT/AACAAG 1 -- ut314Minor allele frequency- A:0.10NA 126
    rs1849594551,2
    --52471939(+) GTTTAC/TAAGAA 1 -- ut310--------
    rs1889744681,2
    --52472041(+) GGTATC/TAGCTT 1 -- ut310--------
    rs1912597701,2
    C--52472173(+) ATTGTA/TAACTC 1 -- ut310--------
    rs1124313071,2
    C,F--52472266(+) TGTAAC/TCAAGT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1892580401,2
    C--52472403(+) ATATAA/TCCCTT 1 -- int10--------
    rs1464703421,2
    F--52472473(+) GGGGTA/GGACTG 2 H Y mis11Minor allele frequency- G:0.00NA 4550
    rs2012076931,2
    C--52472479(+) GACTGC/TAGTTA 2 T A mis11Minor allele frequency- T:0.00EU 1323

    HapMap Linkage Disequilibrium report for NID2 (52471520 - 52535946 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NID2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv85620CNV Insertion16902084
    nsv901947CNV Gain21882294
    nsv901948CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NID2
    DNA2.0 Custom Variant and Variant Library Synthesis for NID2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605399    OMIM disorders: --


    Find genes that share disorders with NID2           About GenesLikeMe

    Genetic Association Database (GAD): NID2

    Export disorders for NID2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NID2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with NID2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nidogen-2: a new basement membrane protein with diverse binding properties. (PubMed id 9733643)1, 2, 3 Kohfeldt E.... Timpl R. (J. Mol. Biol. 1998)
    2. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)1, 4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
    3. The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin. (PubMed id 11956183)1, 2 Tu H....Pihlajaniemi T. (J. Biol. Chem. 2002)
    4. Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer. (PubMed id 17328794)1, 9 Ulazzi L....Negrini M. (Mol. Cancer 2007)
    5. Hypermethylation of TWIST1 and NID2 in tumor tissues and voided urine in urinary bladder cancer patients. (PubMed id 23682613)1 Yegin Z....Buyukalpelli R. (DNA Cell Biol. 2013)
    6. Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2. (PubMed id 23681936)1 Martino-Echarri E....RodrA-guez-Manzaneque J.C. (Int. J. Cancer 2013)
    7. Clinical significance of decreased nidogen-2 expression in the tumor tissue and serum of patients with hepatocellular carcinoma. (PubMed id 21815147)1 Cheng Z.X....Chen X.L. (J Surg Oncol 2012)
    8. NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva. (PubMed id 21558411)1 Guerrero-Preston R....Sidransky D. (Cancer Prev Res (Phila) 2011)
    9. Nidogen-2: a new serum biomarker for ovarian cancer. (PubMed id 19883638)1 Kuk C....Diamandis E.P. (Clin. Biochem. 2010)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22795 HGNC: 13389 AceView: NID2 Ensembl:ENSG00000087303 euGenes: HUgn22795
    ECgene: NID2 H-InvDB: NID2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NID2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NID2 gene:
    Search GeneIP for patents involving NID2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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