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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NID2 Gene

protein-coding GIFtS: 54
GCID: GC14M052471

nidogen 2 (osteonidogen)

Explore 8 diseases affiliated with
NID2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nidogen 2 (Osteonidogen)¹ ²
NID-2² ³
Nidogen-2¹
Osteonidogen³
Osteonidogen³

External Ids:	HGNC: 13389¹	Entrez Gene: 22795²	Ensembl: ENSG00000087303⁷	OMIM: 605399⁵	UniProtKB: Q14112³

Export aliases for NID2 gene to outside databases

Previous GC identifers: GC14M049794 GC14M046267 GC14M050461 GC14M051541 GC14M032632

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NID2:

This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein

that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement

membrane.(provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: NID2_HUMAN, Q14112

Function: Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to

perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions

Gene Wiki entry for NID2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NID2 gene promoter:
Oct-B1 E2F-4 E2F-3a E2F-5 oct-B3 oct-B2 E2F-2 E2F-1 E2F Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NID2 promoter sequence

Search SABiosciences Chromatin IP Primers for NID2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NID2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q22.1

NID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NID2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M052471: view genomic region (about GC identifiers)

Start:	52,471,520 bp from pter	End:	52,535,946 bp from pter
Size:	64,427 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NID2_HUMAN, Q14112 (See protein sequence)

Recommended Name: Nidogen-2 precursor

Size: 1375 amino acids; 151254 Da

Subunit: Interacts with LAMA2 (By similarity). Interacts with COL13A1

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane

Sequence caution: Sequence=BAA13087.1; Type=Frameshift; Positions=54, 68, 150, 172; Sequence=BAA24112.1;

Type=Frameshift; Positions=54, 68, 150, 172;

Secondary accessions: A8K6I7 B4DU19 O43710

Alternative splicing: 2 isoforms: Q14112-1 Q14112-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NID2: NX_Q14112

Post-translational modifications:

Highly N- and O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14112

NID2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_031387.3

ENSEMBL proteins:

ENSP00000216286 ENSP00000452190 ENSP00000443730

Human Recombinant Protein Products for NID2:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals NID2 Proteins Novus Biologicals NID2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NID2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	--	--
GO:0005604	basement membrane	IEA	--
GO:0009986	cell surface	IEA	--
GO:0031012	colocalizes with extracellular matrix	ISS	--

NID2 for ontologies About GeneDecksing

NID2 Antibody Products:

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	Uscn ELISAs and CLIAs for NID2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NID2 for domains About GeneDecksing

5/14 InterPro domains/families (see all 14):

IPR000033 LDLR_classB_rpt

IPR003886 Nidogen_extracell_dom

IPR001881 EGF-like_Ca-bd

IPR000742 EG-like_dom

IPR000716 Thyroglobulin_1

Graphical View of Domain Structure for InterPro Entry Q14112

ProtoNet protein and cluster: Q14112

5/6 Blocks protein families (see all 6):

IPB000033 Low-density lipoprotein receptor

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000716 Thyroglobulin type-1

IPB001881 EGF-like calcium-binding

IPB003886 Nidogen

UniProtKB/Swiss-Prot: NID2_HUMAN, Q14112

Similarity: Contains 5 EGF-like domains

Similarity: Contains 5 LDL-receptor class B repeats

Similarity: Contains 1 NIDO domain

Similarity: Contains 1 nidogen G2 beta-barrel domain

Similarity: Contains 2 thyroglobulin type-1 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NID2_HUMAN, Q14112

Function: Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to

perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	11956183
GO:0005518	collagen binding	TAS	9733643

NID2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NID2:

Decreased viability

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nid2):

cellular

normal

NID2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NID2

miRNA Products:		OriGene 3'-UTR Clone: NID2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NID2
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate NID2 (see all 22):
		hsa-miR-199b-3p hsa-let-7d hsa-miR-199a-3p hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-3129-5p hsa-let-7c

		SwitchGear 3'UTR luciferase reporter plasmid: NID2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NID2 (see all 7) OriGene shRNA RFP: NID2 OriGene siRNA: NID2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NID2
		Sirion Biotech Custom design and validation of potent shRNA sequences against NID2

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NID2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NID2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NID2 (NM_007361)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NID2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NID2

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/13 Interacting proteins for NID2 (Q14112^{2, 3} ENSP00000216286⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SKIL	P12757²^,³	MINT-61686 I2D: score=3
HSPG2	P98160³, ENSP00000363827⁴	I2D: score=3 STRING: ENSP00000363827
LAMC1	P11047³, ENSP00000258341⁴	I2D: score=3 STRING: ENSP00000258341
COL1A1	P02452³, ENSP00000225964⁴	I2D: score=1 STRING: ENSP00000225964
FBLN2	P98095³, ENSP00000384169⁴	I2D: score=1 STRING: ENSP00000384169

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	9733643
GO:0007160	cell-matrix adhesion	IEA	--

NID2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NID2
Search CenterWatch for drugs/clinical trials and news about NID2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NID2 gene:

NM_007361.3

Unigene Cluster for NID2:

Nidogen 2 (osteonidogen)

Hs.369840 [show with all ESTs]

Unigene Representative Sequence: NM_007361

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216286(uc001wzo.3 uc010tqs.2 uc010tqt.1 uc001wzp.3)

ENST00000556686 ENST00000555310 ENST00000556572 ENST00000553297 ENST00000557051

ENST00000554284 ENST00000541773

miRNA Products:		OriGene 3'-UTR Clone: NID2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NID2
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate NID2 (see all 22):
		hsa-miR-199b-3p hsa-let-7d hsa-miR-199a-3p hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-3129-5p hsa-let-7c

		SwitchGear 3'UTR luciferase reporter plasmid: NID2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NID2 (see all 7) OriGene shRNA RFP: NID2 OriGene siRNA: NID2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NID2
		Sirion Biotech Custom design and validation of potent shRNA sequences against NID2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NID2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NID2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NID2 (NM_007361)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NID2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NID2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NID2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NID2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NID2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NID2

Additional cDNA sequence:

AJ223500.1 AK291652.1 AK298542.1 AK300462.1 BC035608.1 D86425.1

15 DOTS entries:

DT.92424619 DT.102834395 DT.102834399 DT.315583 DT.91731826 DT.102834397 DT.91807905 DT.99927789

DT.120759531 DT.120759544 DT.91942186 DT.91944120 DT.95097582 DT.95266308 DT.120759563

24/137 AceView cDNA sequences (see all 137):

AV659395 C01906 CA415339 CB269743 AI864093 BX500200 NM_007361 AW664140

AA112244 BX112956 AL603185 AI655040 H87019 BX648241 AW950557 AJ223500

AA628541 BX508494 BI196227 AL701878 AI572102 AA339380 AA722945 CF130460

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NID2 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	^	16a	·	16b	^	17a	·	17b	^	18	^
SP1:									-																		-				-																-
SP2:
SP3:																																					-		-
SP4:
SP5:

ExUns:	19a	·	19b	·	19c	^	20a	·	20b	^	21a	·	21b	^	22
SP1:	-								-
SP2:
SP3:
SP4:									-				-
SP5:	-

ECgene alternative splicing isoforms for NID2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NID2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATCAATAT

About this image

NID2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Multinuclear Myocytes

Skeletal Muscle

Anterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Cervical Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Vertebrae Column Muscles

Multinuclear Myocytes

Skeletal Muscle

Pelvic Muscles

Multinuclear Myocytes

Skeletal Muscle

Posterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

Trophoblast-like cells (Generation of tropho...)

Primitive gut tube-like cells (A scalable, suspensi...)

DKK1-induced cells (Derivation of cardio...)

Cardiomyocyte-like progenitor cells (Derivation of cardio...)

Mesendoderm (Derivation and sorti...)

Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

See NID2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NID2

SOURCE GeneReport for Unigene cluster: Hs.369840

UniProtKB/Swiss-Prot: NID2_HUMAN, Q14112

Tissue specificity: Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including NID2:

Polycomb & Trithorax Target Genes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NID2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NID2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NID2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NID2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NID2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NID2 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NID2¹	nidogen 2 (osteonidogen)	67.92(n) 67.28(a)		423583 XM_421471.3 XP_421471.3
lizard (Anolis carolinensis)	Reptilia	NID2⁶	--	64(a)	1 ↔ 1	GL343501.1(479570-564142)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8084²	Xenopus laevis transcribed sequence with moderate similarity more	75.29(n)		CF283341.1
zebrafish (Danio rerio)	Actinopterygii	nid2²	nidogen 2 (osteonidogen)	73.33(n)		373088 AY193826.1
fruit fly (Drosophila melanogaster)	Insecta	Ndg¹	Nidogen/entactin	47.9(n) 36.6(a)		36089 NM_206074.1 NP_995796.1
worm (Caenorhabditis elegans)	Secernentea	nid-1⁶	NIDogen (basement membrane protein family member (...	21(a)	1 → many	V(12910097-12917205)

ENSEMBL Gene Tree for NID2 (if available)
TreeFam Gene Tree for NID2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NID2 gene

LRP5² LRP6² LRP2² SORL1² LRP1B² EGF² LDLR² LRP5L²

LRP4² VLDLR² NID1² LRP8² LRP1²

8 SIMAP similar genes for NID2 using alignment to 4 protein entries: NID2_HUMAN (see all proteins):

DKFZp686D12108 NID1 LRP1 LDLR LRP5L NELL2

FBLN2 PROS1

NID2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151032833^1,2	C	other	52520480(+)	`GTTTTC/TGGGGT`	2	K E	mis¹		1		NA	4550
rs34688526^1,2	C	--	52471025(+)	`TAAATAAAT/- GGCCT`	2	--	int¹ ds500¹		1		NA	2
rs201119834^1,2		--	52471070(+)	`TTTCTC/GATAAA`	2	--	ds500¹ int¹		0	--	--	--	--
rs113869191^1,2	C	--	52471263(+)	`CCTACT/-TTAGT`	2	--	ut3¹ ds500¹		1		CSA	2
rs73301059^1,2	C	--	52471264(+)	`CCTACG/TTAGTA`	2	--	ut3¹ ds500¹		1		WA	2
rs187883344^1,2		--	52471321(+)	`ACATTC/TTCGGG`	2	--	ds500¹ ut3¹		0	--	--	--	--
rs192664435^1,2		--	52471323(+)	`ATTCTC/TGGGGG`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs117652481^1,2	C,F	--	52471366(+)	`ATTTAC/TCACCA`	2	--	ds500¹ ut3¹		1		EA	120
rs183368526^1,2		--	52471410(+)	`GAAAGG/TAGAAT`	2	--	ds500¹ ut3¹		0	--	--	--	--
rs188778050^1,2		--	52471761(+)	`TTCCCA/TTCAGT`	2	--	ut3¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NID2 (52471520 - 52535946 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NID2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NID2 for disorders           About GeneDecksing

OMIM gene information: 605399    OMIM disorders: --

8 diseases for NID2:    About MalaCards

pulmonary function keratopathy squamous cell carcinoma keratoconus

hepatocellular carcinoma ovarian cancer carcinoma neuronitis

Export disorders for NID2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NID2 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with NID2)

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Nidogen-2: a new basement membrane protein with diverse binding properties. (PubMed id 9733643)^{1, 2, 3} Kohfeldt E.... Timpl R. (1998)
The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin. (PubMed id 11956183)^{1, 2} Tu H....Pihlajaniemi T. (2002)
Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer. (PubMed id 17328794)^{1, 9} Ulazzi L....Negrini M. (2007)
Clinical significance of decreased nidogen-2 expressi on in the tumor tissue and serum of patients with hepatocellular carcinoma. (PubMed id 21815147)¹ Cheng Z.X....Chen X.L. (2012)
NID2 and HOXA9 promoter hypermethylation as biomarker s for prevention and early detection in oral cavity squamous cell carcinoma tis sues and saliva. (PubMed id 21558411)¹ Guerrero-Preston R....Sidransky D. (2011)
Nidogen-2: a new serum biomarker for ovarian cancer. (PubMed id 19883638)¹ Kuk C....Diamandis E.P. (2010)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture. (PubMed id 17008882)¹ Nischt R....Breitkreutz D. (2007)
Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)¹ Wilk J.B....O'Connor G.T. (2007)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22795	HGNC: 13389	AceView: NID2	Ensembl:ENSG00000087303	euGenes: HUgn22795
ECgene: NID2	H-InvDB: NID2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NID2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NID2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NID2 gene:
Search GeneIP for patents involving NID2

GeneCards and IP:
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