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NID1 Gene

protein-coding   GIFtS: 65
GCID: GC01M236139

Nidogen 1

(Previous name: nidogen (enactin))
(Previous symbol: NID)
  See NID1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nidogen 11 2     enactin2
NID1 2 3 5     entactin2
NID-12 3     nidogen-12
Nidogen (Enactin)1     Entactin3

External Ids:    HGNC: 78211   Entrez Gene: 48112   Ensembl: ENSG000001169627   OMIM: 1313905   UniProtKB: P145433   

Export aliases for NID1 gene to outside databases

Previous GC identifers: GC01M232466 GC01M234205 GC01M206590


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NID1 Gene:
This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with
several other components of basement membranes, and may play a role in cell interactions with the extracellular
matrix. (provided by RefSeq, Jul 2008)

GeneCards Summary for NID1 Gene:
NID1 (nidogen 1) is a protein-coding gene. Diseases associated with NID1 include goodpasture syndrome. GO annotations related to this gene include laminin-1 binding and calcium ion binding. An important paralog of this gene is LRP6.

UniProtKB/Swiss-Prot: NID1_HUMAN, P14543
Function: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also
binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions

Gene Wiki entry for NID1 (Entactin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_167186.2  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NID1 gene promoter:
         Pax-5   GATA-3   HNF-4alpha2   LCR-F1   HNF-4alpha1   MEF-2A   HEN1   SRY   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNID1 promoter sequence
   Search Chromatin IP Primers for NID1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NID1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q43   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q43

NID1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NID1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M236139:  view genomic region     (about GC identifiers)

Start:
236,139,130 bp from pter      End:
236,228,481 bp from pter
Size:
89,352 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NID1_HUMAN, P14543 (See protein sequence)
Recommended Name: Nidogen-1 precursor  
Size: 1247 amino acids; 136377 Da
Subunit: Interacts with FBLN1 and LGALS3BP (By similarity). Interacts with PLXDC1
1 PDB 3D structure from and Proteopedia for NID1:
1NDX (3D)    
Secondary accessions: Q14942 Q59FL2 Q5TAF2 Q5TAF3 Q86XD7
Alternative splicing: 2 isoforms:  P14543-1   P14543-2   

Explore the universe of human proteins at neXtProt for NID1: NX_P14543

Explore proteomics data for NID1 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated1
  • Glycosylation2 at Thr310, Thr311, Ser327, Ser330, Ser333, Thr339, Thr347, Thr350, Thr922, Thr935
  • Modification sites at PhosphoSitePlus

  • See NID1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002499.2  
    ENSEMBL proteins: 
     ENSP00000355554   ENSP00000264187  
    Reactome Protein details: P14543

    NID1 Human Recombinant Protein Products:

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    Novus Biologicals NID1 Protein
    Novus Biologicals NID1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NID1 

    NID1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NID1
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    NID1 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for NID1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 15):
     IPR000033 LDLR_classB_rpt
     IPR000742 EG-like_dom
     IPR000716 Thyroglobulin_1
     IPR009017 GFP
     IPR026823 cEGF

    Graphical View of Domain Structure for InterPro Entry P14543

    ProtoNet protein and cluster: P14543

    Selected Blocks protein domains (see all 6):
    IPB000033 Low-density lipoprotein receptor
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000716 Thyroglobulin type-1
    IPB001881 EGF-like calcium-binding
    IPB003886 Nidogen


    UniProtKB/Swiss-Prot: NID1_HUMAN, P14543
    Similarity: Contains 6 EGF-like domains
    Similarity: Contains 4 LDL-receptor class B repeats
    Similarity: Contains 1 NIDO domain
    Similarity: Contains 1 nidogen G2 beta-barrel domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    Find genes that share domains with NID1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NID1_HUMAN, P14543
    Function: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also
    binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0005518collagen binding IDA--
    GO:0043236laminin binding IDA--
    GO:0043237laminin-1 binding IEA--
         
    Find genes that share ontologies with NID1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nid1):
     behavior/neurological  cardiovascular system  cellular  muscle  nervous system 
     other  vision/eye 

    Find genes that share phenotypes with NID1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NID1: Nid1tm1Dong Nid1tm1Ron

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NID1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NID1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NID1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NID1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NID1:
    hsa-mir-29b-3p (MIRT005669), hsa-mir-186-5p (MIRT045142), hsa-mir-124-3p (MIRT002921), hsa-mir-106b-5p (MIRT044313)

    Block miRNA regulation of human, mouse, rat NID1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NID1 (see all 29):
    hsa-miR-30c hsa-miR-140-5p hsa-miR-3910 hsa-miR-3607-3p hsa-miR-323b-3p hsa-miR-2110 hsa-miR-29a hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmidNID1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NID1
    Predesigned siRNA for gene silencing in human, mouse, rat NID1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NID1 (NM_002508)
    Sino Biological Human cDNA Clone for NID1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NID1
    Addgene plasmids for NID1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NID1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NID1_HUMAN, P14543: Secreted, extracellular space, extracellular matrix, basement membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IDA--
    GO:0005605basal lamina IEA--
    GO:0031012colocalizes with extracellular matrix ISS--

    Find genes that share ontologies with NID1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NID1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3Non-integrin membrane-ECM interactions
    Laminin interactions0.35


    Find genes that share SuperPaths with NID1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NID1
        Cell adhesion ECM remodeling


    2 Reactome Pathways for NID1
        Laminin interactions
    Degradation of the extracellular matrix


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NID1
    Interactions:

        Search GeneGlobe Interaction Network for NID1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NID1 (P145432, 3 ENSP000002641874) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61679 I2D: score=3 
    COL1A1P024523, ENSP000002259644I2D: score=2 STRING: ENSP00000225964
    FGAP026713, ENSP000003063614I2D: score=2 STRING: ENSP00000306361
    FGBP026753, ENSP000003060994I2D: score=2 STRING: ENSP00000306099
    LACRTQ9GZZ83, ENSP000002578674I2D: score=2 STRING: ENSP00000257867
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007160cell-matrix adhesion IEA--
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0032836glomerular basement membrane development IEA--

    Find genes that share ontologies with NID1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NID1

    1 DrugBank Compound for NID1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--17139284 17016423 1499567

    Selected Novoseek inferred chemical compound relationships for NID1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 61.1 9 10671375 (3), 1694169 (1), 16322790 (1), 9196442 (1) (see all 7)
    heparan sulfate 46.5 6 16322790 (2), 9257191 (1), 9115292 (1), 11530869 (1) (see all 5)
    guanidine 43.2 2 2119467 (2)
    thioflavin t 41.9 2 11376898 (1)
    fibrinogen 34 22 1680863 (3), 8433553 (3), 16322790 (2), 8307776 (2) (see all 7)
    chondroitin sulfate 31 3 16322790 (1), 9088920 (1), 1388118 (1)
    dithiothreitol 11.3 1 8764158 (1)
    heparin 3.38 2 8441232 (1), 2340512 (1)
    calcium 0 5 2191952 (3), 2119632 (1)
    zinc 0 1 8636109 (1)



    Find genes that share compounds with NID1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NID1 gene: 
    NM_002508.2  

    Unigene Cluster for NID1:

    Nidogen 1
    Hs.356624  [show with all ESTs]
    Unigene Representative Sequence: NM_002508
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366595 ENST00000264187(uc009xgc.3 uc001hxo.3 uc009xgd.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NID1 (see all 29):
    hsa-miR-30c hsa-miR-140-5p hsa-miR-3910 hsa-miR-3607-3p hsa-miR-323b-3p hsa-miR-2110 hsa-miR-29a hsa-miR-29c
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat NID1

    Additional mRNA sequence: 

    AB209448.1 AK091903.1 AK297234.1 BC045606.1 M27445.1 M30269.1 

    5 DOTS entries:

    DT.95242319  DT.91711901  DT.91824076  DT.95077663  DT.95164677 

    Selected AceView cDNA sequences (see all 360):

    BQ549455 CD615001 AA733037 AA826256 CR590230 BE018553 H21723 AW069455 
    BQ002869 BQ581313 BX367140 BG289659 BM985308 AI131425 CN483074 BM476904 
    BQ549657 AI270317 H02874 BI870481 AI311537 AA333052 R58194 CR611614 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NID1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
    SP1:                                                                                                                                          
    SP2:                                                                                            -                                             
    SP3:                                                        -     -     -                                                                     


    ECgene alternative splicing isoforms for NID1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NID1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTGTATG
    NID1 Expression
    About this image


    NID1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 16 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
    NID1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NID1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356624
        Custom PCR Arrays for NID1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NID1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NID1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nid11 , 5 nidogen 11, 5 83.56(n)1
    85.22(a)1
      13 (5.26 cM)5
    180731  NM_010917.21  NP_035047.21 
     134376025 
    chicken
    (Gallus gallus)
    Aves NID11 nidogen 1 67.96(n)
    68.49(a)
      395531  XM_419556.4  XP_419556.3 
    lizard
    (Anolis carolinensis)
    Reptilia NID16
    nidogen 1
    57(a)
    1 ↔ 1
    1(219142887-219190876)
    African clawed frog
    (Xenopus laevis)
    Amphibia BM261216.12   -- 72.18(n)    BM261216.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgbb01h022 mgbb01h02 73.32(n)   326973  CK026890.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ndg6
    Nidogen/entactin
    26(a)
    1 → many
    2R(6201423-6209405)
    worm
    (Caenorhabditis elegans)
    Secernentea nid-16
    Protein NID-1, isoform a (nid-1) mRNA, complete cd...
    22(a)
    1 → many
    V(12910113-12917221) WBGene00003738


    ENSEMBL Gene Tree for NID1 (if available)
    TreeFam Gene Tree for NID1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NID1 gene
    LRP62  LRP52  LRP22  LRP1B2  EGF2  LDLR2  LRP5L2  LRP42  
    VLDLR2  NID22  LRP82  LRP12  
    2 SIMAP similar genes for NID1 using alignment to 2 protein entries:     NID1_HUMAN (see all proteins):
    NID2    DKFZp686D12108

    Find genes that share paralogs with NID1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NID1 (see all 2232)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358354
    A colorectal cancer sample4--see VAR_0358352 F S mis40--------
    rs113343901,2
    C--206641154(+) TTTCA-/TTTTTT 1 -- int1 trp30--------
    rs21454311,2
    A--206677881(+) AAAAAA/TAAATA 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1439362221,2
    C--206677881(+) AAAAA-/TAAATA 1 -- int10--------
    rs38319891,2
    C--236143302(+) AAAAAA/-CAAGA 1 -- int12Minor allele frequency- -:0.25NA 4
    rs30774911,2
    C--236149055(+) TATAT-/AT/TA 
            
    GCATA
    1 -- int11NA 2
    rs57818551,2
    C--236149734(+) GCATC-/AAAAAA 1 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs38319901,2
    C--236154061(+) CAGGA-/CTA   
      CATGGA
    ATGAG
    1 -- int11Minor allele frequency- CTACATGGA:0.00NA 2
    rs114047771,2
    C--236154416(+) CACAC-/A/    
       AC
    /CA
    CCCCA
    1 -- int10--------
    rs113254871,2
    C--236160902(+) TTTTTT/-AAATT 1 -- int1 trp31Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for NID1 (236139130 - 236228481 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NID1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725363CNV Deletion23290073
    esv2725374CNV Deletion23290073
    nsv509679CNV Insertion20534489
    nsv832958CNV Loss17160897
    esv9322CNV Gain19470904

    Human Gene Mutation Database (HGMD): NID1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NID1
    DNA2.0 Custom Variant and Variant Library Synthesis for NID1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 131390    OMIM disorders: --

    1 disease for NID1:    
    About MalaCards
    goodpasture syndrome

    1 disease from the University of Copenhagen DISEASES database for NID1:
    Alport syndrome

    Find genes that share disorders with NID1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NID1 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glomerulonephritis 38.3 4 2067216 (1), 2119467 (1)
    carcinoma adenoid cystic 26.1 1 1315206 (1)
    choriocarcinoma 22.4 2 8433553 (1)
    prostate carcinoma 19.9 4 1527019 (2), 7823596 (1)
    nephritis 17.5 1 2119467 (1)
    renal disease 13 2 10571774 (1), 2067216 (1)
    liver fibrosis 9.79 1 11264572 (1)
    adenocarcinoma 4.67 1 1315206 (1)
    cancer 1.92 2 17328794 (1)
    necrosis 0 1 15949695 (1)

    Genetic Association Database (GAD): NID1

    Export disorders for NID1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NID1 gene, integrated from 10 sources (see all 154):
    (articles sorted by number of sources associating them with NID1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic sequences and structural organization of the human nidogen gene (NID). (PubMed id 7557988)1, 2, 3, 9 Zimmermann K.... Nischt R. (Genomics 1995)
    2. Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43. (PubMed id 2471408)1, 2, 3 Olsen D.R.... Uitto J. (Am. J. Hum. Genet. 1989)
    3. Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk. (PubMed id 21478494)1, 4 Nan H....Han J. (Hum. Mol. Genet. 2011)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo. (PubMed id 16574105)1, 2 Lee H.K.... Park H.T. (FEBS Lett. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Urokinase binding to laminin-nidogen. Structural requirements and interactions with heparin. (PubMed id 1499567)1, 7 Stephens R.W....Vaheri A. (Eur. J. Biochem. 1992)
    8. Human nidogen gene: structural and functional characterization of the 5'-flanking region. (PubMed id 1906509)1, 2 Fazio M.J.... Uitto J. (J. Invest. Dermatol. 1991)
    9. Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene. (PubMed id 2574658)1, 2 Nagayoshi T.... Uitto J. (DNA 1989)
    10. Potential role of entactin in hemostasis. Specific interaction of entactin with fibrinogen A alpha and B beta chains. (PubMed id 1680863)1, 9 Wu C. and Chung A.E. (J. Biol. Chem. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4811 HGNC: 7821 AceView: NID Ensembl:ENSG00000116962 euGenes: HUgn4811
    ECgene: NID1 H-InvDB: NID1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NID1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NID1 gene:
    Search GeneIP for patents involving NID1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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