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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NID1 Gene

protein-coding   GIFtS: 62
GCID: GC01M236139

nidogen 1

(Previous name: nidogen (enactin) )
(Previous symbol: NID)
 Explore 32 diseases affiliated with
NID1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NID1    

Aliases
for NID1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nidogen 11 2     Nidogen (Enactin)1
NID1 2 3 5     Enactin1
Entactin3     Nidogen-11
NID-12 3     Entactin3

External Ids:    HGNC: 78211   Entrez Gene: 48112   Ensembl: ENSG000001169627   OMIM: 1313905   UniProtKB: P145433   

Export aliases for NID1 gene to outside databases

Previous GC identifers: GC01M232466 GC01M234205 GC01M206590


Summaries
for NID1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NID1:
This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several
other components of basement membranes, and may play a role in cell interactions with the extracellular matrix.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NID1_HUMAN, P14543
Function: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also
binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions

Gene Wiki entry for NID1 (Entactin)


Genomic Views
for NID1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NID1 gene promoter:
         Pax-5   GATA-3   HNF-4alpha2   LCR-F1   HNF-4alpha1   MEF-2A   HEN1   SRY   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NID1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NID1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NID1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q43   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q43

NID1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NID1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M236139:  view genomic region     (about GC identifiers)

Start:
 236,139,130 bp from pter      End:
 236,228,481 bp from pter
Size:
 89,352 bases      Orientation:
 minus strand

Proteins
for NID1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NID1_HUMAN, P14543 (See protein sequence)
Recommended Name: Nidogen-1 precursor  
Size: 1247 amino acids; 136377 Da
Subunit: Interacts with FBLN1 and LGALS3BP (By similarity). Interacts with PLXDC1
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane
1 PDB 3D structure from and Proteopedia for NID1:
1NDX (3D)    
Secondary accessions: Q14942 Q59FL2 Q5TAF2 Q5TAF3 Q86XD7
Alternative splicing: 2 isoforms:  P14543-1   P14543-2   

Explore the universe of human proteins at neXtProt for NID1: NX_P14543

Post-translational modifications:

  • N- and O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14543

    • NID1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002499.2  
    ENSEMBL proteins: 
     ENSP00000264187   ENSP00000355554  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NID1 (Nidogen-1/Entactin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NID1
    OriGene Protein Over-expression Lysate: NID1
    OriGene Custom Protein Services for NID1 
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    Novus Biologicals NID1 Protein
    Novus Biologicals NID1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NID1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane ----
    GO:0005605basal lamina IEA--
    GO:0031012colocalizes with extracellular matrix ISS--
    GO:0071944cell periphery IEA--


    NID1 for ontologies           About GeneDecksing



    NID1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NID1
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    Assay Products for NID1: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NID1

    Protein Domains /
    Families
    for NID1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NID1 for domains           About GeneDecksing

    5/14 InterPro domains/families (see all 14):
     IPR000033 LDLR_classB_rpt
     IPR003886 Nidogen_extracell_dom
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom
     IPR000716 Thyroglobulin_1

    Graphical View of Domain Structure for InterPro Entry P14543

    ProtoNet protein and cluster: P14543

    5/6 Blocks protein families (see all 6):
    IPB000033 Low-density lipoprotein receptor
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000716 Thyroglobulin type-1
    IPB001881 EGF-like calcium-binding
    IPB003886 Nidogen


    UniProtKB/Swiss-Prot: NID1_HUMAN, P14543
    Similarity: Contains 6 EGF-like domains
    Similarity: Contains 4 LDL-receptor class B repeats
    Similarity: Contains 1 NIDO domain
    Similarity: Contains 1 nidogen G2 beta-barrel domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    Function
    for NID1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NID1_HUMAN, P14543
    Function: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also
    binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions

    miRNA
    Products:            		miRTarBase miRNAs that target NID1:
    hsa-mir-29b (MIRT005669)

    OriGene 3'-UTR Clone: NID1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NID1
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate NID1 (see all 29):
    hsa-miR-30c hsa-miR-140-5p hsa-miR-3910 hsa-miR-3607-3p hsa-miR-323b-3p hsa-miR-2110 hsa-miR-29a hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmid: NID1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NID1 (see all 4)
    OriGene shRNA RFP: NID1
    OriGene siRNA: NID1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NID1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NID1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NID1 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NID1 (NM_002508)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NID1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NID1 

    Cell Line
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    Search LifeMap BioReagents cell lines for NID1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NID1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005518collagen binding IEA--
    GO:0043237laminin-1 binding IEA--
    GO:0050840extracellular matrix binding ----


    NID1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NID1: Nid1tm1Dong Nid1tm1Ron
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nid1):
     behavior/neurological  cardiovascular system  cellular  muscle  nervous system 
     other  vision/eye 

    NID1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NID1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_ECM remodeling
    		Cell adhesion_ECM remodeling1.00
    		Metalloproteases in connective tissue degradation0.31
    		Cell adhesion ECM remodeling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for NID1
        Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation


    1 GeneGo (Thomson Reuters) Pathway for NID1
        Cell adhesion ECM remodeling



    NID1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NID1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for NID1 (P145432, 3 ENSP000002641874) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61679 I2D: score=3 
    COL1A1P024523, ENSP000002259644I2D: score=2 STRING: ENSP00000225964
    FGAP026713, ENSP000003063614I2D: score=2 STRING: ENSP00000306361
    FGBP026753, ENSP000003060994I2D: score=2 STRING: ENSP00000306099
    LACRTQ9GZZ83, ENSP000002578674I2D: score=2 STRING: ENSP00000257867
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007160cell-matrix adhesion IEA--
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0030198extracellular matrix organization ----
    GO:0032836glomerular basement membrane development IEA--


    NID1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NID1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NID1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NID1

    1 DrugBank Compound for NID1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--17139284 17016423 1499567

    10/13 Novoseek chemical compound relationships for NID1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 61.1 9 10671375 (3), 1694169 (1), 16322790 (1), 9196442 (1) (see all 7)
    heparan sulfate 46.5 6 16322790 (2), 9257191 (1), 9115292 (1), 11530869 (1) (see all 5)
    guanidine 43.2 2 2119467 (2)
    thioflavin t 41.9 2 11376898 (1)
    fibrinogen 34 22 1680863 (3), 8433553 (3), 16322790 (2), 8307776 (2) (see all 7)
    chondroitin sulfate 31 3 16322790 (1), 9088920 (1), 1388118 (1)
    dithiothreitol 11.3 1 8764158 (1)
    heparin 3.38 2 8441232 (1), 2340512 (1)
    calcium 0 5 2191952 (3), 2119632 (1)
    zinc 0 1 8636109 (1)

    Search CenterWatch for drugs/clinical trials and news about NID1 

    Transcripts
    for NID1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NID1 gene: 
    NM_002508.2  

    Unigene Cluster for NID1:

    Nidogen 1
    Hs.356624  [show with all ESTs]
    Unigene Representative Sequence: NM_002508
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264187(uc009xgc.3 uc001hxo.3 uc009xgd.3) ENST00000366595


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NID1
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate NID1 (see all 29):
    hsa-miR-30c hsa-miR-140-5p hsa-miR-3910 hsa-miR-3607-3p hsa-miR-323b-3p hsa-miR-2110 hsa-miR-29a hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmid: NID1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NID1 (see all 4)
    OriGene shRNA RFP: NID1
    OriGene siRNA: NID1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NID1
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209448.1 AK091903.1 AK297234.1 BC045606.1 M27445.1 M30269.1 

    5 DOTS entries:

    DT.95242319  DT.91711901  DT.91824076  DT.95077663  DT.95164677 

    24/360 AceView cDNA sequences (see all 360):

    BQ002869 CR590230 CD615010 CR611614 CF530096 CB269307 T47984 AI349421 
    W76647 AW338118 R58194 BM721570 BM974594 BC045606 H21723 AA300269 
    AA826256 BX281509 BQ581313 BQ549455 AI336313 CR609449 AI139518 AI537432 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NID1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
    SP1:                                                                                                                                          
    SP2:                                                                                            -                                             
    SP3:                                                        -     -     -                                                                     


    ECgene alternative splicing isoforms for NID1

    Expression
    for NID1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NID1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTTGTATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NID1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeCiliary Marginal ZoneCiliary Marginal Zone CellsNeural Ectoderm
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePelvic MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    White adipocyte-like cells (Differentiation of ...)Adipose

    See NID1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NID1

    SOURCE GeneReport for Unigene cluster: Hs.356624
        SABiosciences Custom PCR Arrays for NID1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NID1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NID1

    Orthologs
    for NID1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NID1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NID11 nidogen 1 68.07(n)
    68.81(a)    		   395531  XM_419556.3  XP_419556.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NID16
    		 --
    		 56(a)
    		 1 ↔ 1
    		 1(219143163-219187425)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BM261216.12   -- 72.18(n)    BM261216.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mgbb01h022 mgbb01h02 73.32(n)   326973  CK026890.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ndg6
    		 Nidogen/entactin
    		 24(a)
    		 1 → many
    		 2R(6201423-6209405)
    worm
    (Caenorhabditis elegans)    		 Secernentea nid-16
    		 NIDogen (basement membrane protein family member (...
    		 21(a)
    		 1 → many
    		 V(12910097-12917205)


    ENSEMBL Gene Tree for NID1 (if available)
    TreeFam Gene Tree for NID1 (if available) 

    Paralogs
    for NID1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NID1 gene
    LRP52  LRP62  LRP22  SORL12  LRP1B2  EGF2  LDLR2  LRP5L2  
    LRP42  VLDLR2  NID22  LRP82  LRP12  
    2 SIMAP similar genes for NID1 using alignment to 2 protein entries:     NID1_HUMAN (see all proteins):
    NID2    DKFZp686D12108

    NID1 for paralogs           About GeneDecksing



    Genomic Variants
    for NID1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1842 NCBI SNPs in NID1 are shown (see all 1842)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1996357981,2
    		--236138644(+) TTTTA-/TTTTTT 1 -- ds50010--------
    rs1443527281,2
    		--236138721(+) CTCACG/TGCAGC 1 -- ds50010--------
    rs351478951,2
    		C--236138811(+) GCTAAT/-TTTTT 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs607923011,2
    		C--236138812(+) TTTTT-/TGATGT 1 -- ds50010--------
    rs1930238001,2
    		--236138850(+) TCCCTG/TTATTG 1 -- ds50010--------
    rs1857097701,2
    		--236138974(+) TAAGGC/TTTTTT 1 -- ds50010--------
    rs1149066601,2
    		--236139082(+) ATGAAT/GCAGCC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1882739001,2
    		--236139095(+) CCAACA/GTTAAA 1 -- ds50010--------
    rs46601351,2
    		C,F,A,--236139141(+) TTTTTA/TAAAAA 1 -- ut317Minor allele frequency- T:0.35NA WA EA 366
    rs1931708151,2
    		--236139171(+) TTGTAC/TAGCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NID1 (236139130 - 236228481 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NID1
         1 Indel: 59991
    Human Gene Mutation Database (HGMD): NID1

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    Disorders / Diseases
    for NID1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NID1 for disorders           About GeneDecksing

    OMIM gene information: 131390    OMIM disorders: --

    20/32 diseases for NID1 (see all 32):    About MalaCards
    laurence-moon syndrome    cicatricial pemphigoid    bullous keratopathy    goodpasture syndrome
    keratopathy    adenoid cystic carcinoma    adenoiditis    pleomorphic adenoma
    poliomyelitis    colonic polyps    diabetic retinopathy    hirschsprung's disease
    nephritis    choriocarcinoma    glomerulonephritis    constipation
    liver fibrosis    embryonal carcinoma    teratocarcinoma    prostate carcinoma

    1 disease from the University of Copenhagen DISEASES database for NID1:
    Alport syndrome

    10/16 Novoseek disease relationships for NID1 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glomerulonephritis 38.3 4 2067216 (1), 2119467 (1)
    carcinoma adenoid cystic 26.1 1 1315206 (1)
    choriocarcinoma 22.4 2 8433553 (1)
    prostate carcinoma 19.9 4 1527019 (2), 7823596 (1)
    nephritis 17.5 1 2119467 (1)
    renal disease 13 2 10571774 (1), 2067216 (1)
    liver fibrosis 9.79 1 11264572 (1)
    adenocarcinoma 4.67 1 1315206 (1)
    cancer 1.92 2 17328794 (1)
    necrosis 0 1 15949695 (1)


    Export disorders for NID1 gene to outside databases

    Publications
    for NID1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NID1 gene, integrated from 9 sources (see all 152):
    (articles sorted by number of sources associating them with NID1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic sequences and structural organization of the human nidogen gene (NID). (PubMed id 7557988)1, 2, 3, 9 Zimmermann K.... Nischt R. (1995)
    2. Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43. (PubMed id 2471408)1, 2, 3 Olsen D.R.... Uitto J. (1989)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Identification of the basement membrane protein nidog en as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo. (PubMed id 16574105)1, 2 Lee H.K....Park H.T. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Urokinase binding to laminin-nidogen. Structural requirements and interactions with heparin. (PubMed id 1499567)1, 7 Stephens R.W....Vaheri A. (1992)
    7. Human nidogen gene: structural and functional characterization of the 5'-flanking region. (PubMed id 1906509)1, 2 Fazio M.J.... Uitto J. (1991)
    8. Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene. (PubMed id 2574658)1, 2 Nagayoshi T.... Uitto J. (1989)
    9. Potential role of entactin in hemostasis. Specific interaction of entactin with fibrinogen A alpha and B beta chains. (PubMed id 1680863)1, 9 Wu C. and Chung A.E. (1991)
    10. Adhesion of cultured human kidney mesangial cells to native entactin: role of integrin receptors. (PubMed id 9686320)1, 9 Yi X.Y....Fish A.J. (1998)

    External Searches for NID1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NID1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4811 HGNC: 7821 AceView: NID Ensembl:ENSG00000116962 euGenes: HUgn4811
    ECgene: NID1 H-InvDB: NID1

    Other Databases showing NID1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NID1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NID1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NID1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NID1 gene:
    Search GeneIP for patents involving NID1

    GeneCards and IP:
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