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Aliases for NICN1 Gene

Aliases for NICN1 Gene

  • Nicolin 1 2 3
  • Tubulin Polyglutamylase Complex Subunit 5 3 4
  • NPCEDRG 3 4
  • PGs5 3 4
  • Nicolin-1 3

External Ids for NICN1 Gene

Previous GeneCards Identifiers for NICN1 Gene

  • GC03P048862
  • GC03M049314
  • GC03M049419
  • GC03M049435

Summaries for NICN1 Gene

Entrez Gene Summary for NICN1 Gene

  • This protein encoded by this gene localizes to the nucleus and is expressed in numerous tissues including brain, testis, liver, and kidney. This refseq contains genomic sequence in its 3' UTR which is not supported by experimental evidence. Computer predictions indicate that this region of the 3' UTR contains hairpin-forming self-complementary sequence which is possibly excised after transcription. This gene has a pseudogene on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for NICN1 Gene

NICN1 (Nicolin 1) is a Protein Coding gene. Diseases associated with NICN1 include glycine encephalopathy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NICN1 Gene

Genomics for NICN1 Gene

Regulatory Elements for NICN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NICN1 Gene

49,422,333 bp from pter
49,429,326 bp from pter
6,994 bases
Minus strand

Genomic View for NICN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NICN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NICN1 Gene

Proteins for NICN1 Gene

  • Protein details for NICN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8IZQ2

    Protein attributes for NICN1 Gene

    213 amino acids
    Molecular mass:
    24202 Da
    Quaternary structure:
    • Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.

    Alternative splice isoforms for NICN1 Gene


neXtProt entry for NICN1 Gene

Proteomics data for NICN1 Gene at MOPED

Post-translational modifications for NICN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NICN1 Gene

No data available for DME Specific Peptides for NICN1 Gene

Domains for NICN1 Gene

Protein Domains for NICN1 Gene


Suggested Antigen Peptide Sequences for NICN1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NICN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NICN1 Gene

Function for NICN1 Gene

Animal Model Products

CRISPR Products

miRNA for NICN1 Gene

miRTarBase miRNAs that target NICN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NICN1 Gene

Localization for NICN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NICN1 Gene

Subcellular locations from

Jensen Localization Image for NICN1 Gene COMPARTMENTS Subcellular localization image for NICN1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NICN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with NICN1: view

Pathways for NICN1 Gene

SuperPathways for NICN1 Gene

No Data Available

Interacting Proteins for NICN1 Gene

Gene Ontology (GO) - Biological Process for NICN1 Gene


No data available for Pathways by source for NICN1 Gene

Transcripts for NICN1 Gene

Unigene Clusters for NICN1 Gene

Nicolin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NICN1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NICN1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - -
SP3: -
SP6: -

Relevant External Links for NICN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NICN1 Gene

mRNA expression in normal human tissues for NICN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for NICN1 Gene Hs.191460

mRNA Expression by UniProt/SwissProt for NICN1 Gene

Tissue specificity: High expression level is found in brain, testis, liver and kidney. Weak expression in spleen, leukocytes, small intestine and colon.
genes like me logo Genes that share expressions with NICN1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for NICN1 Gene

Orthologs for NICN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NICN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NICN1 35
  • 90.3 (n)
  • 92.96 (a)
NICN1 36
  • 93 (a)
(Canis familiaris)
Mammalia NICN1 35
  • 91.86 (n)
  • 94.37 (a)
NICN1 36
  • 94 (a)
(Mus musculus)
Mammalia Nicn1 35
  • 86.54 (n)
  • 89.2 (a)
Nicn1 16
Nicn1 36
  • 89 (a)
(Pan troglodytes)
Mammalia NICN1 35
  • 99.68 (n)
  • 99.51 (a)
NICN1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nicn1 35
  • 86.7 (n)
  • 90.14 (a)
(Monodelphis domestica)
Mammalia NICN1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia NICN1 36
  • 64 (a)
(Anolis carolinensis)
Reptilia NICN1 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mst1r 35
  • 61.35 (n)
  • 60.09 (a)
(Danio rerio)
Actinopterygii nicn1 35
  • 55.5 (n)
  • 51.2 (a)
nicn1 36
  • 50 (a)
Species with no ortholog for NICN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NICN1 Gene

Gene Tree for NICN1 (if available)
Gene Tree for NICN1 (if available)

Paralogs for NICN1 Gene Pseudogenes for NICN1 Gene

genes like me logo Genes that share paralogs with NICN1: view

No data available for Paralogs for NICN1 Gene

Variants for NICN1 Gene

Sequence variations from dbSNP and Humsavar for NICN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6446272 -- 49,425,854(+) AAAGG(A/G)CCAGC intron-variant
rs6446273 -- 49,427,712(+) AAGGG(C/T)GAGAG intron-variant
rs6446274 -- 49,428,168(+) tgagc(C/T)gagat intron-variant
rs6446275 -- 49,429,438(+) TTAAC(A/G)CGGAA upstream-variant-2KB
rs6762593 -- 49,426,493(+) CAAAG(A/G)TCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NICN1 Gene

Variant ID Type Subtype PubMed ID
nsv834687 CNV Loss 17160897

Relevant External Links for NICN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NICN1 Gene

Disorders for NICN1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NICN1 Gene in MalaCards »

(1) Diseases for NICN1 Gene including...

(1) University of Copenhagen DISEASES for NICN1 Gene

Relevant External Links for NICN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NICN1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for NICN1 Gene

Publications for NICN1 Gene

  1. Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein. (PMID: 12392556) Backofen B. … Leeb T. (Eur. J. Biochem. 2002) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 48
  4. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan A.R. … Ferguson L.R. (Hum. Immunol. 2010) 3 48
  5. Cloning and characterization of the NPCEDRG gene promoter. (PMID: 20821255) Hou D. … Chen Z. (Mol. Cell. Biochem. 2011) 3

Products for NICN1 Gene

Sources for NICN1 Gene

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