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NICN1 Gene

protein-coding   GIFtS: 47
GCID: GC03M049460

Nicolin 1

  See NICN1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nicolin 11 2
Tubulin Polyglutamylase Complex Subunit 52 3
NPCEDRG2 3
PGs52 3
nicolin-12

External Ids:    HGNC: 183171   Entrez Gene: 842762   Ensembl: ENSG000001450297   OMIM: 6115165   UniProtKB: Q9BSH33   

Export aliases for NICN1 gene to outside databases

Previous GC identifers: GC03P048862 GC03M049314 GC03M049419 GC03M049435


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NICN1 Gene:
This protein encoded by this gene localizes to the nucleus and is expressed in numerous tissues including brain,
testis, liver, and kidney. This refseq contains genomic sequence in its 3' UTR which is not supported by
experimental evidence. Computer predictions indicate that this region of the 3' UTR contains hairpin-forming
self-complementary sequence which is possibly excised after transcription. This gene has a pseudogene on
chromosome X. (provided by RefSeq, Jul 2008)

GeneCards Summary for NICN1 Gene:
NICN1 (nicolin 1) is a protein-coding gene. Diseases associated with NICN1 include glycine encephalopathy.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the NICN1 gene promoter:
         SRF   GR   SRF (504 AA)   ATF-2   GR-beta   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNICN1 promoter sequence
   Search Chromatin IP Primers for NICN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NICN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

NICN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NICN1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049460:  view genomic region     (about GC identifiers)

Start:
49,459,766 bp from pter      End:
49,466,759 bp from pter
Size:
6,994 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NICN1_HUMAN, Q9BSH3 (See protein sequence)
Recommended Name: Nicolin-1  
Size: 213 amino acids; 24202 Da
Subunit: Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1
(By similarity)
Secondary accessions: Q8IZQ2
Alternative splicing: 2 isoforms:  Q9BSH3-1   Q9BSH3-2   

Explore the universe of human proteins at neXtProt for NICN1: NX_Q9BSH3

Explore proteomics data for NICN1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NICN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115692.1  
    ENSEMBL proteins: 
     ENSP00000273598   ENSP00000413115   ENSP00000402335  

    NICN1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NICN1
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    Novus Biologicals NICN1 Protein
    Novus Biologicals NICN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NICN1

     
    Search eBioscience for Proteins for NICN1 

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    NICN1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NICN1
    Cloud-Clone Corp. CLIAs for NICN1
    Search eBioscience for ELISAs for NICN1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9BSH3


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NICN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NICN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NICN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NICN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NICN1:
    hsa-let-7e-5p (MIRT051677)

    Block miRNA regulation of human, mouse, rat NICN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NICN1 (see all 11):
    hsa-miR-3194-5p hsa-miR-3166 hsa-miR-122 hsa-miR-586 hsa-miR-1324 hsa-miR-3692 hsa-miR-4267 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidNICN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NICN1
    Predesigned siRNA for gene silencing in human, mouse, rat NICN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NICN1

    Clone
    Products:
         
    OriGene clones in human, mouse for NICN1 (see all 6)
    OriGene ORF clones in mouse, rat for NICN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NICN1 (NM_032316)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NICN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NICN1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NICN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NICN1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NICN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NICN1_HUMAN, Q9BSH3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    mitochondrion2
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with NICN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NICN1
    Interactions:

        Search GeneGlobe Interaction Network for NICN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NICN1 (ENSP000002735984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPGS1ENSP000003522654STRING: ENSP00000352265
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NICN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NICN1 gene: 
    NM_032316.3  

    Unigene Cluster for NICN1:

    Nicolin 1
    Hs.191460  [show with all ESTs]
    Unigene Representative Sequence: NM_032316
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273598(uc003cwz.1 uc011bcr.2) ENST00000423832 ENST00000497742
    ENST00000436744 ENST00000422593 ENST00000494057 ENST00000461015
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NICN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NICN1 (see all 11):
    hsa-miR-3194-5p hsa-miR-3166 hsa-miR-122 hsa-miR-586 hsa-miR-1324 hsa-miR-3692 hsa-miR-4267 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidNICN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NICN1
    Predesigned siRNA for gene silencing in human, mouse, rat NICN1
    Clone
    Products:
         
    OriGene clones in human, mouse for NICN1 (see all 6)
    OriGene ORF clones in mouse, rat for NICN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NICN1 (NM_032316)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NICN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NICN1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NICN1
    OriGene qSTAR qPCR primer pairs in human, mouse for NICN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NICN1
      QuantiTect SYBR Green Assays in human, mouse, rat NICN1
      QuantiFast Probe-based Assays in human, mouse, rat NICN1

    Additional mRNA sequence: 

    AJ299740.1 AK094248.1 AK301846.1 AK313073.1 BC005050.1 BC050653.1 

    13 DOTS entries:

    DT.92010435  DT.92418890  DT.91955712  DT.100804815  DT.100027200  DT.120904077  DT.92418892  DT.95293059 
    DT.441687  DT.91941373  DT.114158  DT.120904286  DT.120904696 

    Selected AceView cDNA sequences (see all 246):

    BI522578 BQ062172 BM874742 BX365555 D13811 CA308954 AA743897 AU098698 
    AA962122 BE677482 AI912969 AU103013 AI290815 AI081517 AA701640 CR613547 
    BC007546 AI128880 AK091738 BM782408 BI910395 CA433307 F11299 NM_000481 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NICN1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                                                  -     -                           
    SP2:                                -     -           -     -                           
    SP3:                                                  -                                 
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for NICN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NICN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NICN1 Expression
    About this image


    NICN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    NICN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NICN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191460

    UniProtKB/Swiss-Prot: NICN1_HUMAN, Q9BSH3
    Tissue specificity: High expression level is found in brain, testis, liver and kidney. Weak expression in spleen,
    leukocytes, small intestine and colon

        Custom PCR Arrays for NICN1
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    QuantiFast Probe-based Assays in human, mouse, rat NICN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NICN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NICN1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nicn11 , 5 nicolin 11, 5 86.54(n)1
    89.2(a)1
      9 (59.18 cM)5
    662571  NM_025449.31  NP_079725.11 
     1082904575 
    lizard
    (Anolis carolinensis)
    Reptilia NICN16
    nicolin 1
    61(a)
    1 ↔ 1
    2(147133788-147140841)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mst1r1 macrophage stimulating 1 receptor (c-met-related tyrosine more 61.35(n)
    60.09(a)
      493453  NM_001008090.1  NP_001008091.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nicn11 nicolin 1 55.5(n)
    51.2(a)
      445216  NM_001003610.2  NP_001003610.1 


    ENSEMBL Gene Tree for NICN1 (if available)
    TreeFam Gene Tree for NICN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NICN1 gene

    Find genes that share paralogs with NICN1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NICN1
    PGOHUM00000241270


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NICN1 (see all 221)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1450382901,2
    C--49391596(+) AGCCCC/TGGAAA 1 -- ds50010--------
    rs793933391,2
    C,F--49391662(+) TGAGAC/ACCTCT 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs14645661,2
    C,F,A,H--49391677(-) CAAGGG/AAATGA 1 -- ds500125Minor allele frequency- A:0.46MN NS EA NA WA CSA 2670
    rs1143411741,2
    F--49391696(+) GACCTA/TTCCAT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1467875451,2
    C--49391882(+) GCGTGC/TGTGCA 1 -- ds50010--------
    rs2016437091,2
    --49391921(+) CTGCAC/TTGGCA 1 -- ds50010--------
    rs2010807821,2
    C--49391937(+) CAACCC/TGCAAA 1 -- ds50010--------
    rs348127881,2
    C,F--49391944(+) CAAACG/ACCACC 1 -- ds50012Minor allele frequency- A:0.00NA 4582
    rs1489179291,2
    C--49391948(+) CGCCAA/CCATTT 1 -- ds50010--------
    rs1382594791,2
    C,F--49391995(+) TCCTGC/TGGAGC 1 -- ds50012Minor allele frequency- T:0.00NA EU 5241

    HapMap Linkage Disequilibrium report for NICN1 (49459766 - 49466759 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NICN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834687CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NICN1
    DNA2.0 Custom Variant and Variant Library Synthesis for NICN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611516    OMIM disorders: --

    1 disease for NICN1:    
    About MalaCards
    glycine encephalopathy

    1 disease from the University of Copenhagen DISEASES database for NICN1:
    Glycine encephalopathy

    Find genes that share disorders with NICN1           About GenesLikeMe

    Genetic Association Database (GAD): NICN1
    Human Genome Epidemiology (HuGE) Navigator: NICN1 (2 documents)

    Export disorders for NICN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NICN1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NICN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein. (PubMed id 12392556)1, 2, 3, 9 Backofen B.... Leeb T. (Eur. J. Biochem. 2002)
    2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    3. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1, 4 Morgan A.R....Ferguson L.R. (Hum. Immunol. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cloning and characterization of the NPCEDRG gene promoter. (PubMed id 20821255)1 Hou D....Chen Z. (Mol. Cell. Biochem. 2011)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Genomic organization of the murine aminomethyltransferase gene (Amt). (PubMed id 12487019)1 Backofen B. and Leeb T. (DNA Seq. 2002)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84276 HGNC: 18317 AceView: AMTandNICN1 Ensembl:ENSG00000145029 euGenes: HUgn84276
    ECgene: NICN1 H-InvDB: NICN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NICN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NICN1 gene:
    Search GeneIP for patents involving NICN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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