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Aliases for NHSL2 Gene

Aliases for NHSL2 Gene

  • NHS Like 2 2 3 5

External Ids for NHSL2 Gene

Previous GeneCards Identifiers for NHSL2 Gene

  • GC0XP071271
  • GC0XP071353
  • GC0XP064888
  • GC0XP071130

Summaries for NHSL2 Gene

GeneCards Summary for NHSL2 Gene

NHSL2 (NHS Like 2) is a Protein Coding gene. An important paralog of this gene is NHS.

Additional gene information for NHSL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHSL2 Gene

Genomics for NHSL2 Gene

Regulatory Elements for NHSL2 Gene

Enhancers for NHSL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH072099 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12 +192.2 192248 6 CTCF PKNOX1 TBL1XR1 EBF1 ZIC2 RELA YY1 POLR2A EED ATF7 PIN4 RTL5 NHSL2 FLJ44635 CXCR3 OGT PIR32507 PIR46676
GH0XH072107 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12 +197.2 197177 1 KLF17 RAD21 GLIS2 ATF7 EGR2 CEBPB ZEB2 ZNF398 ZNF781 ZFP69B RTL5 FLJ44635 ZMYM3 NHSL2 HDAC8 OGT PIR32507 PIR46676
GH0XH072018 1.2 Ensembl ENCODE 13.4 +108.8 108813 2 ELF3 ATF1 RB1 ARNT RAD21 RARA GLIS2 EGR1 ZNF143 RCOR1 NHSL2 RTL5 RPS26P11 GC0XM071966 RNU6-1078P
GH0XH072109 0.9 ENCODE dbSUPER 17.2 +201.7 201678 6 PKNOX1 RFX1 EBF1 BMI1 ZIC2 ZNF623 ZFHX2 POLR2A RCOR1 EGR2 NHSL2 PIN4 PIR32507 PIR46676
GH0XH072028 1.2 Ensembl ENCODE 12.4 +119.0 119048 2 TBP FOXA2 PKNOX1 INSM2 RFX5 YY1 RCOR1 FOS DEK EGR2 RTL5 NHSL2 PIN4 RPS26P11 GC0XM071966 RNU6-1078P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NHSL2 on UCSC Golden Path with GeneCards custom track

Promoters for NHSL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247162 383 1600 CTCF ZNF777 ZNF133 ZFHX2 CTBP1 GLIS2 POLR2A PATZ1 ZSCAN29 EZH2

Genomic Location for NHSL2 Gene

71,910,818 bp from pter
72,161,750 bp from pter
250,933 bases
Plus strand

Genomic View for NHSL2 Gene

Genes around NHSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHSL2 Gene

Proteins for NHSL2 Gene

  • Protein details for NHSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NHS-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RN94

    Protein attributes for NHSL2 Gene

    709 amino acids
    Molecular mass:
    76301 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NHSL2 Gene

Post-translational modifications for NHSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NHSL2 Gene

Domains & Families for NHSL2 Gene

Gene Families for NHSL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NHSL2 Gene


Suggested Antigen Peptide Sequences for NHSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NHS family.
  • Belongs to the NHS family.
genes like me logo Genes that share domains with NHSL2: view

Function for NHSL2 Gene

Phenotypes From GWAS Catalog for NHSL2 Gene

genes like me logo Genes that share phenotypes with NHSL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NHSL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NHSL2 Gene

Localization for NHSL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NHSL2 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NHSL2 Gene

Pathways & Interactions for NHSL2 Gene

SuperPathways for NHSL2 Gene

No Data Available

Interacting Proteins for NHSL2 Gene

Gene Ontology (GO) - Biological Process for NHSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with NHSL2: view

No data available for Pathways by source and SIGNOR curated interactions for NHSL2 Gene

Drugs & Compounds for NHSL2 Gene

No Compound Related Data Available

Transcripts for NHSL2 Gene

mRNA/cDNA for NHSL2 Gene

(9) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NHSL2 Gene

NHS-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NHSL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NHSL2 Gene

No ASD Table

Relevant External Links for NHSL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NHSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NHSL2 Gene

This gene is overexpressed in Whole Blood (x12.1).

Protein differential expression in normal tissues from HIPED for NHSL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.4), Esophagus (16.9), Monocytes (15.5), CD8 Tcells (8.7), and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NHSL2 Gene

Protein tissue co-expression partners for NHSL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NHSL2 Gene:


SOURCE GeneReport for Unigene cluster for NHSL2 Gene:


Evidence on tissue expression from TISSUES for NHSL2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NHSL2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NHSL2 Gene

Orthologs for NHSL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHSL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NHSL2 33 34
  • 99.18 (n)
(Bos Taurus)
Mammalia NHSL2 33 34
  • 90.2 (n)
(Canis familiaris)
Mammalia NHSL2 33 34
  • 88.1 (n)
(Mus musculus)
Mammalia Nhsl2 33 16 34
  • 86.49 (n)
(Rattus norvegicus)
Mammalia Nhsl2 33
  • 84.86 (n)
(Monodelphis domestica)
Mammalia NHSL2 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
-- 34
  • 22 (a)
(Gallus gallus)
Aves NHSL2 33
  • 63.43 (n)
-- 34
  • 52 (a)
-- 34
  • 3 (a)
(Anolis carolinensis)
Reptilia NHSL2 34
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nhsl2 33
  • 55.51 (n)
(Danio rerio)
Actinopterygii LOC794153 33
  • 51.96 (n)
NHSL2 34
  • 25 (a)
Species where no ortholog for NHSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHSL2 Gene

Gene Tree for NHSL2 (if available)
Gene Tree for NHSL2 (if available)

Paralogs for NHSL2 Gene

Paralogs for NHSL2 Gene

genes like me logo Genes that share paralogs with NHSL2: view

Variants for NHSL2 Gene

Sequence variations from dbSNP and Humsavar for NHSL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs72630038 Uncertain significance 72,134,530(+) TGAGC(A/G)AGGAT intron-variant, reference, missense
rs1000007468 -- 72,027,949(+) GGGTG(A/G)GAGTT intron-variant
rs1000012553 -- 72,032,708(+) ACAAA(A/T)ATTAT intron-variant
rs1000066424 -- 71,949,246(+) CCCCC(A/G)ACAAG intron-variant
rs1000069807 -- 72,119,276(+) ATATG(G/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NHSL2 Gene

Variant ID Type Subtype PubMed ID
esv1106651 CNV insertion 17803354
esv2740219 CNV deletion 23290073
esv2758872 CNV loss 17122850
esv3304353 CNV mobile element insertion 20981092
esv3441303 CNV insertion 20981092
nsv475997 CNV novel sequence insertion 20440878
nsv477615 CNV novel sequence insertion 20440878
nsv517419 CNV gain 19592680
nsv525711 CNV gain 19592680
nsv6956 CNV deletion 18451855

Variation tolerance for NHSL2 Gene

Gene Damage Index Score: 5.79; 73.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NHSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHSL2 Gene

Disorders for NHSL2 Gene

Relevant External Links for NHSL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NHSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NHSL2 Gene

Publications for NHSL2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 60
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60

Products for NHSL2 Gene

Sources for NHSL2 Gene

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