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Aliases for NHSL2 Gene

Aliases for NHSL2 Gene

  • NHS-Like 2 2 3

External Ids for NHSL2 Gene

Previous GeneCards Identifiers for NHSL2 Gene

  • GC0XP071271
  • GC0XP071353
  • GC0XP064888
  • GC0XP071130

Summaries for NHSL2 Gene

GeneCards Summary for NHSL2 Gene

NHSL2 (NHS-Like 2) is a Protein Coding gene. An important paralog of this gene is NHS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHSL2 Gene

Genomics for NHSL2 Gene

Regulatory Elements for NHSL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NHSL2 Gene

71,910,818 bp from pter
72,161,750 bp from pter
250,933 bases
Plus strand

Genomic View for NHSL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NHSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHSL2 Gene

Proteins for NHSL2 Gene

  • Protein details for NHSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NHS-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RN94

    Protein attributes for NHSL2 Gene

    709 amino acids
    Molecular mass:
    76301 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NHSL2 Gene

Proteomics data for NHSL2 Gene at MOPED

Post-translational modifications for NHSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NHSL2 Gene

No data available for DME Specific Peptides for NHSL2 Gene

Domains & Families for NHSL2 Gene

Protein Domains for NHSL2 Gene


Suggested Antigen Peptide Sequences for NHSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NHS family.
  • Belongs to the NHS family.
genes like me logo Genes that share domains with NHSL2: view

No data available for Gene Families for NHSL2 Gene

Function for NHSL2 Gene

Phenotypes for NHSL2 Gene

genes like me logo Genes that share phenotypes with NHSL2: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NHSL2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for NHSL2 Gene

Localization for NHSL2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NHSL2 Gene

Pathways & Interactions for NHSL2 Gene

SuperPathways for NHSL2 Gene

No Data Available

Interacting Proteins for NHSL2 Gene

Gene Ontology (GO) - Biological Process for NHSL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NHSL2 Gene

Drugs & Compounds for NHSL2 Gene

No Compound Related Data Available

Transcripts for NHSL2 Gene

mRNA/cDNA for NHSL2 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NHSL2 Gene

NHS-like 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NHSL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHSL2 Gene

No ASD Table

Relevant External Links for NHSL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHSL2 Gene

mRNA expression in normal human tissues for NHSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NHSL2 Gene

This gene is overexpressed in Whole Blood (x12.1).

Protein differential expression in normal tissues from HIPED for NHSL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.4), Esophagus (16.9), Monocytes (15.5), CD8 Tcells (8.7), and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NHSL2 Gene

SOURCE GeneReport for Unigene cluster for NHSL2 Gene Hs.397836

genes like me logo Genes that share expression patterns with NHSL2: view

Protein tissue co-expression partners for NHSL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NHSL2 Gene

Orthologs for NHSL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHSL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NHSL2 35
  • 90.2 (n)
  • 87.5 (a)
NHSL2 36
  • 85 (a)
(Canis familiaris)
Mammalia NHSL2 35
  • 88.1 (n)
  • 85.05 (a)
NHSL2 36
  • 83 (a)
(Mus musculus)
Mammalia Nhsl2 35
  • 86.49 (n)
  • 84.66 (a)
Nhsl2 16
Nhsl2 36
  • 84 (a)
(Pan troglodytes)
Mammalia NHSL2 35
  • 99.18 (n)
  • 99.18 (a)
NHSL2 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Nhsl2 35
  • 84.86 (n)
  • 83.12 (a)
(Monodelphis domestica)
Mammalia NHSL2 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
-- 36
  • 46 (a)
(Gallus gallus)
Aves NHSL2 35
  • 63.43 (n)
  • 59.02 (a)
-- 36
  • 52 (a)
-- 36
  • 3 (a)
(Anolis carolinensis)
Reptilia NHSL2 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nhsl2 35
  • 55.51 (n)
  • 50.17 (a)
(Danio rerio)
Actinopterygii LOC794153 35
  • 51.96 (n)
  • 44.13 (a)
NHSL2 36
  • 25 (a)
Species with no ortholog for NHSL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHSL2 Gene

Gene Tree for NHSL2 (if available)
Gene Tree for NHSL2 (if available)

Paralogs for NHSL2 Gene

Paralogs for NHSL2 Gene

genes like me logo Genes that share paralogs with NHSL2: view

Variants for NHSL2 Gene

Sequence variations from dbSNP and Humsavar for NHSL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3936164 -- 72,085,111(+) TATTG(G/T)CCTCA intron-variant
rs4076908 -- 72,109,470(-) acaaa(A/C/T)aacaa intron-variant
rs4076909 -- 72,109,823(-) GCCAT(A/G)TAAAG intron-variant
rs4132935 -- 72,138,720(+) CACTT(C/T)CTGGA reference, missense
rs4986596 -- 71,978,261(-) TAAGG(A/T)GATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NHSL2 Gene

Variant ID Type Subtype PubMed ID
dgv2451e1 CNV Complex 17122850
nsv517419 CNV Gain 19592680
nsv6956 CNV Loss 18451855
esv1106651 CNV Insertion 17803354
esv2740219 CNV Deletion 23290073
esv268632 CNV Insertion 20981092
nsv525711 CNV Gain 19592680

Variation tolerance for NHSL2 Gene

Gene Damage Index Score: 5.79; 73.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NHSL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHSL2 Gene

Disorders for NHSL2 Gene

Relevant External Links for NHSL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NHSL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NHSL2 Gene

Publications for NHSL2 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 67
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for NHSL2 Gene

Sources for NHSL2 Gene

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