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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NHSL2 Gene

protein-coding   GIFtS: 38
GCID: GC0XP071130

NHS-Like 2

  Search for NHSL2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NHS-Like 21 2
NHS-Like Protein 22

External Ids:    HGNC: 337371   Entrez Gene: 3405272   Ensembl: ENSG000002041317   UniProtKB: Q5HYW23   

Export aliases for NHSL2 gene to outside databases

Previous GC identifers: GC0XP071271 GC0XP071353 GC0XP064888


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NHSL2 Gene: 
NHSL2 (NHS-like 2) is a protein-coding gene. An important paralog of this gene is NHSL1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NHSL2 gene promoter:
         Max1   Nkx2-5   E47   Egr-4   IRF-2   COMP1   Hand1   Pax-4a   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNHSL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NHSL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

NHSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NHSL2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP071130:  view genomic region     (about GC identifiers)

Start:
71,130,938 bp from pter      End:
71,363,424 bp from pter
Size:
232,487 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NHSL2_HUMAN, Q5HYW2 (See protein sequence)
Recommended Name: NHS-like protein 2  
Size: 709 amino acids; 76301 Da
Secondary accessions: B2RN94

Explore the universe of human proteins at neXtProt for NHSL2: NX_Q5HYW2

Explore proteomics data for NHSL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5HYW2

  • NHSL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NHSL2 Protein Expression
    REFSEQ proteins: NP_001013649.2  
    ENSEMBL proteins: 
     ENSP00000362781   ENSP00000424079   ENSP00000444617   ENSP00000444914  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR024845 NHS_fam

    Graphical View of Domain Structure for InterPro Entry Q5HYW2

    ProtoNet protein and cluster: Q5HYW2

    UniProtKB/Swiss-Prot: NHSL2_HUMAN, Q5HYW2
    Similarity: Belongs to the NHS family


    NHSL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NHSL2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NHSL2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NHSL2

    Search CenterWatch for drugs/clinical trials and news about NHSL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for NHSL2 gene: 
    NM_001013627.2  

    Unigene Cluster for NHSL2:

    NHS-like 2
    Hs.397836  [show with all ESTs]
    Unigene Representative Sequence: BC033261
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373677(uc004eak.1 uc010nli.2) ENST00000510661 ENST00000540800(uc011mqa.2)
    ENST00000535692
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    BC033261.1 BC136756.1 

    4 DOTS entries:

    DT.91920061  DT.91750780  DT.102820562  DT.97801289 

    7 AceView cDNA sequences:

    BC033261 BG683083 BQ889754 BE079933 BE079980 BE079982 BM873441 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NHSL2 expression in normal human tissues (normalized intensities)      NHSL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGCTCGG
    NHSL2 Expression
    About this image


    NHSL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood

    See NHSL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NHSL2

    SOURCE GeneReport for Unigene cluster: Hs.397836
        SABiosciences Custom PCR Arrays for NHSL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHSL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NHSL2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nhsl21 , 5 NHS-like 21, 5 86.49(n)1
    84.66(a)1
      X (44.75 cM)5
    1000424801  NM_001163610.11  NP_001157082.11 
     1018493855 
    chicken
    (Gallus gallus)
    Aves NHSL21 NHS-like 2 62.89(n)
    58.24(a)
      422133  XM_420135.3  XP_420135.3 
    lizard
    (Anolis carolinensis)
    Reptilia NHSL26
    Uncharacterized protein
    46(a)
    1 ↔ 1
    GL343603.1(21761-30870)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7941531 NHS-like protein 2-like 50.17(n)
    42.12(a)
      794153  XM_001334017.3  XP_001334053.2 


    ENSEMBL Gene Tree for NHSL2 (if available)
    TreeFam Gene Tree for NHSL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NHSL2 gene
    NHSL12  NHS2  

    NHSL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2815 SNPs in NHSL2 are shown (see all 2815)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59026971,2
    C--71133679(-) GTCCTC/-CCCCT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs1858384071,2
    --71135332(+) TGATTA/CAATCA 1 -- us2k10--------
    rs74717051,2
    C,F,A,H--71135499(+) ACGCTC/TAGAAT 1 -- us2k112Minor allele frequency- T:0.23NS EA WA NA CSA 430
    rs1901099791,2
    --71135521(+) ATGCAA/GGTATT 1 -- us2k10--------
    rs74716711,2
    C,F,A,H--71135538(+) AAAGTG/ATTTTA 1 -- us2k119Minor allele frequency- A:0.16NS EA WA NA CSA 1580
    rs65255411,2
    C,A--71135597(+) TGAGGG/CAGGAG 1 -- us2k18Minor allele frequency- C:0.00WA NA CSA 12
    rs65255421,2
    C,A--71135678(+) AAAACC/TAAATT 1 -- us2k16Minor allele frequency- T:0.00NA WA CSA 8
    rs1865598491,2
    --71135696(+) GTGGTC/GGCACG 1 -- us2k10--------
    rs65255431,2
    C,A--71135700(+) TGGCAT/CGTGCC 1 -- us2k17Minor allele frequency- C:0.00WA NA CSA 10
    rs1923420241,2
    --71135760(+) AGAGTA/GAATTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NHSL2 (71130938 - 71363424 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NHSL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740219CNV Deletion23290073
    esv1106651CNV Insertion17803354
    esv268632CNV Insertion20981092
    nsv6956CNV Loss18451855
    nsv517419CNV Gain19592680
    nsv525711CNV Gain19592680
    dgv2451e1CNV Complex17122850


    Locus Specific Mutation Databases (LSDB): NHSL2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NHSL2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NHSL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340527 HGNC: 33737 AceView: LOC340527 Ensembl:ENSG00000204131 euGenes: HUgn340527
    ECgene: NHSL2 H-InvDB: NHSL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NHSL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NHSL2 gene:
    Search GeneIP for patents involving NHSL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Antibodies for NHSL2
     See all of Abcam's Antibodies, Kits and Proteins for NHSL2
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     Proteins for NHSL2
     Antibodies for NHSL2
     ELISAs for NHSL2
     CLIAs for NHSL2
     Search LifeMap BioReagents cell lines for NHSL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHSL2
     SwitchGear 3'UTR luciferase reporter plasmids for NHSL2
     SwitchGear Promoter luciferase reporter plasmids for NHSL2
     Search ThermoFisher Antibodies for NHSL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHSL2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NHSL2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NHSL2
    Customized:
     lentivirus for stable overexpression of NHSL2
     lentivirus expression plasmids for stable overexpression of NHSL2
     adenovirus for overexpression of NHSL2
     Search LSBio for Antibodies for NHSL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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