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Aliases for NHSL1 Gene

Aliases for NHSL1 Gene

  • NHS Like 1 2 3 5
  • C6orf63 3 4
  • Chromosome 6 Open Reading Frame 63 2
  • NHS-Like 1 3
  • KIAA1357 4

External Ids for NHSL1 Gene

Previous HGNC Symbols for NHSL1 Gene

  • C6orf63

Previous GeneCards Identifiers for NHSL1 Gene

  • GC06M138784
  • GC06M136304
  • GC06M138743

Summaries for NHSL1 Gene

GeneCards Summary for NHSL1 Gene

NHSL1 (NHS Like 1) is a Protein Coding gene. Diseases associated with NHSL1 include nance-horan syndrome. An important paralog of this gene is NHS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHSL1 Gene

Genomics for NHSL1 Gene

Regulatory Elements for NHSL1 Gene

Enhancers for NHSL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NHSL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NHSL1 Gene

Chromosome:
6
Start:
138,422,043 bp from pter
End:
138,692,616 bp from pter
Size:
270,574 bases
Orientation:
Minus strand

Genomic View for NHSL1 Gene

Genes around NHSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHSL1 Gene

Proteins for NHSL1 Gene

  • Protein details for NHSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SYE7-NHSL1_HUMAN
    Recommended name:
    NHS-like protein 1
    Protein Accession:
    Q5SYE7
    Secondary Accessions:
    • Q3ZCS5
    • Q5SYE8
    • Q9P2J0

    Protein attributes for NHSL1 Gene

    Size:
    1610 amino acids
    Molecular mass:
    170668 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12098.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12099.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14156.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14157.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NHSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NHSL1 Gene

Proteomics data for NHSL1 Gene at MOPED

Post-translational modifications for NHSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NHSL1 Gene

No data available for DME Specific Peptides for NHSL1 Gene

Domains & Families for NHSL1 Gene

Protein Domains for NHSL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NHSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5SYE7

UniProtKB/Swiss-Prot:

NHSL1_HUMAN :
  • Belongs to the NHS family.
Family:
  • Belongs to the NHS family.
genes like me logo Genes that share domains with NHSL1: view

No data available for Gene Families for NHSL1 Gene

Function for NHSL1 Gene

Phenotypes for NHSL1 Gene

genes like me logo Genes that share phenotypes with NHSL1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NHSL1 Gene

Localization for NHSL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NHSL1 Gene COMPARTMENTS Subcellular localization image for NHSL1 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NHSL1 Gene

Pathways & Interactions for NHSL1 Gene

SuperPathways for NHSL1 Gene

No Data Available

Interacting Proteins for NHSL1 Gene

Gene Ontology (GO) - Biological Process for NHSL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NHSL1 Gene

Drugs & Compounds for NHSL1 Gene

No Compound Related Data Available

Transcripts for NHSL1 Gene

Unigene Clusters for NHSL1 Gene

NHS-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NHSL1 Gene

No ASD Table

Relevant External Links for NHSL1 Gene

GeneLoc Exon Structure for
NHSL1
ECgene alternative splicing isoforms for
NHSL1

Expression for NHSL1 Gene

mRNA expression in normal human tissues for NHSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NHSL1 Gene

This gene is overexpressed in Plasma (47.0) and Placenta (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NHSL1 Gene



SOURCE GeneReport for Unigene cluster for NHSL1 Gene Hs.652741

mRNA Expression by UniProt/SwissProt for NHSL1 Gene

Q5SYE7-NHSL1_HUMAN
Tissue specificity: Widely expressed. Expressed in adult and fetal brain, fetal eyes, adult lens, kidney, liver and intestine.
genes like me logo Genes that share expression patterns with NHSL1: view

Protein tissue co-expression partners for NHSL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NHSL1 Gene

Orthologs for NHSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHSL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NHSL1 35
  • 82.58 (n)
  • 79.34 (a)
NHSL1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NHSL1 35
  • 83.7 (n)
  • 80.8 (a)
NHSL1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nhsl1 35
  • 81.17 (n)
  • 77.58 (a)
Nhsl1 16
Nhsl1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NHSL1 35
  • 98.96 (n)
  • 98.06 (a)
NHSL1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nhsl1 35
  • 80.42 (n)
  • 76.44 (a)
oppossum
(Monodelphis domestica)
Mammalia NHSL1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves NHSL1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NHSL1 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nhsl1 35
  • 54.57 (n)
  • 49.84 (a)
zebrafish
(Danio rerio)
Actinopterygii nhsl1b 35
  • 60.01 (n)
  • 56.28 (a)
nhsl1a 36
  • 34 (a)
OneToMany
nhsl1b 36
  • 38 (a)
OneToMany
Species with no ortholog for NHSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHSL1 Gene

ENSEMBL:
Gene Tree for NHSL1 (if available)
TreeFam:
Gene Tree for NHSL1 (if available)

Paralogs for NHSL1 Gene

Paralogs for NHSL1 Gene

genes like me logo Genes that share paralogs with NHSL1: view

Variants for NHSL1 Gene

Sequence variations from dbSNP and Humsavar for NHSL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3734305 - 138,431,104(+) TCTCA(C/T)GGGCC reference, missense
rs11540147 - 138,424,161(-) CCCCC(A/G)GCCCT reference, missense
rs5006709 -- 138,607,938(+) CTCCT(A/G)CGAGA intron-variant
rs5015729 -- 138,537,591(+) GTAAG(C/T)TTTAC intron-variant
rs5880383 -- 138,456,917(+) TTACT(-/T)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NHSL1 Gene

Variant ID Type Subtype PubMed ID
esv2752090 CNV Gain 17911159
esv2469347 CNV Deletion 19546169
esv2732769 CNV Deletion 23290073
esv2399126 CNV Deletion 18987734
esv2732770 CNV Deletion 23290073
esv2732771 CNV Deletion 23290073
nsv5499 CNV Loss 18451855
esv1934223 CNV Deletion 18987734

Variation tolerance for NHSL1 Gene

Gene Damage Index Score: 4.65; 65.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NHSL1 Gene

HapMap Linkage Disequilibrium report
NHSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHSL1 Gene

Disorders for NHSL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NHSL1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nance-horan syndrome
  • neonatal hemochromatosis
- elite association - COSMIC cancer census association via MalaCards
Search NHSL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NHSL1

Genetic Association Database (GAD)
NHSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NHSL1
genes like me logo Genes that share disorders with NHSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NHSL1 Gene

Publications for NHSL1 Gene

  1. Identification of the gene for Nance-Horan syndrome (NHS). (PMID: 15466011) Brooks S.P. … Hardcastle A.J. (J. Med. Genet. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3

Products for NHSL1 Gene

Sources for NHSL1 Gene

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