NHSL1 Gene
protein-coding GIFtS: 38
GCID: GC06M138743
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NHS-like 1(Previous name: chromosome 6 open reading frame 63 )
(Previous symbol: C6orf63)
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Aliases
for NHSL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| NHS-Like 11 2 | | C6orf631 2 3 | | KIAA13571 3 | | BA43P8.11 | | Chromosome 6 Open Reading Frame 631 | | NHS-Like Protein 12 |
Export aliases for NHSL1 gene to outside databasesPrevious GC identifers: GC06M138784 GC06M136304 |
Summaries
for NHSL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NHSL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NHSL1 gene promoter:
AREB6 FAC1 GATA-3 p53 HSF1short POU6F1 (c2) Pax-4a GATA-1 GATA-2 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for NHSL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHSL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q23.3 Ensembl cytogenetic band: 6q24.1 HGNC cytogenetic band: 6q23.3NHSL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M138743: view genomic region
(about GC identifiers)
Start:
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138,743,180 bp from pter |
End:
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139,013,708 bp from pter |
Size:
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270,529 bases |
Orientation:
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minus strand |
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Proteins
for NHSL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NHSL1_HUMAN, Q5SYE7 (See
protein sequence)Recommended Name: NHS-like protein 1 Size: 1610 amino acids; 170668 Da
Sequence caution: Sequence=CAI12098.1; Type=Erroneous gene model prediction; Sequence=CAI12099.1; Type=Erroneous genemodel prediction; Sequence=CAI14156.1; Type=Erroneous gene model prediction; Sequence=CAI14157.1; Type=Erroneous genemodel prediction;
Secondary accessions: Q3ZCS5 Q5SYE8 Q9P2J0Alternative splicing: 2 isoforms: Q5SYE7-1 Q5SYE7-2 Explore the universe of human proteins at neXtProt for NHSL1: NX_Q5SYE7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SYE7
NHSL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001137532.1 NP_065197.1
ENSEMBL proteins: ENSP00000394546 ENSP00000344672 ENSP00000344582 ENSP00000433523 ENSP00000434958
Human Recombinant Protein Products:
NHSL1 Antibody Products:
Assay Products for NHSL1: |
Protein
Domains /
Families
for NHSL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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NHSL1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5SYE7ProtoNet protein and cluster: Q5SYE7 UniProtKB/Swiss-Prot: NHSL1_HUMAN, Q5SYE7Similarity: Belongs to the NHS family |
Function
for NHSL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHSL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHSL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NHSL1 (NM_001144060) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NHSL1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NHSL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHSL1 |
1 GenomeRNAi human phenotype for NHSL1:
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Pathways & Interactions
for NHSL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NHSL1
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Drugs & Compounds
for NHSL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for NHSL1
Search CenterWatch for drugs/clinical trials and news about NHSL1
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Transcripts
for NHSL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for NHSL1 gene (2 alternative transcripts): NM_001144060.1 NM_020464.1 Unigene Cluster for NHSL1: NHS-like 1 Hs.652741 [show with all ESTs]Unigene Representative Sequence: NM_0204649 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000427025(uc011edp.2 uc003qhx.3) ENST00000343505 ENST00000342260
ENST00000426841(uc003qhy.2) ENST00000491526 ENST00000533765 ENST00000479393
ENST00000534376 ENST00000468095
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHSL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHSL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NHSL1 (NM_001144060) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NHSL1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NHSL1 |
Additional cDNA sequence: AB037778.1 AK000699.1 AK025199.1 AK025347.1 AK299585.1 AK307584.1 BC020940.1 BC045181.1 BX647246.1 6 DOTS entries: DT.92425378 DT.92425379 DT.99926639 DT.86854017 DT.121316439 DT.75168684 24/85 AceView cDNA sequences (see all 85): AI279404 N80287 BU676507 N27536 AA782243 CK730338 AK025347 BF591161 BM806009 BX107716 BU616048 BE504981 BE327009 AB037778 AW969566 CB164087 AW195689 AI160774 BM782474 BU622609 CA314218 AI094979 AA503387 BM799699
GeneLoc Exon Structure
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Expression
for NHSL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NHSL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTCAAATCA
About this image
See NHSL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NHSL1
SOURCE GeneReport for Unigene cluster: Hs.652741
UniProtKB/Swiss-Prot: NHSL1_HUMAN, Q5SYE7Tissue specificity: Widely expressed. Expressed in adult and fetal brain, fetal eyes, adult lens, kidney, liver andintestine
SABiosciences Custom PCR Arrays for NHSL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHSL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NHSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHSL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHSL1 |
Orthologs
for NHSL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for NHSL1 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for NHSL1 (if available)
TreeFam Gene Tree for NHSL1 (if available) |
Paralogs
for NHSL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NHSL1 gene
- NHSL22 NHS2
NHSL1 for paralogs About GeneDecksing
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Genomic Variants
for NHSL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for NHSL1 (138743180 - 138993180 bp, first 250kb of NHSL1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for NHSL1
2 CNVs: 99726 8529
6 Indels: 81607 94048 94051 94049 47004 94050 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHSL1 |
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Disorders
/ Diseases
for NHSL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NHSL1 for disorders About GeneDecksing
1  disease for NHSL1: About MalaCardsnance-horan syndrome
Export disorders for NHSL1 gene to outside databases
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Publications
for NHSL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NHSL1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with NHSL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the gene for Nance-Horan syndrome (NHS). (PubMed id 15466011)1, 2 Brooks S.P.... Hardcastle A.J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1 Nagase T.... Ohara O. (2000)
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External Searches for NHSL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NHSL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing NHSL1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NHSL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NHSL1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NHSL1 gene:
Search GeneIP for patents involving NHSL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NHSL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NHSL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHSL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHSL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NHSL1 | | OriGene 3'-UTR Clone for NHSL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHSL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHSL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NHSL1 | | OriGene Custom Protein Services for NHSL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NHSL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHSL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHSL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHSL1 |
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| | | | Search Tocris compounds for NHSL1 |
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 | | | NHSL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHSL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for NHSL1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NHSL1 |
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