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Aliases for NHSL1 Gene

Aliases for NHSL1 Gene

  • NHS Like 1 2 3 5
  • C6orf63 3 4
  • Chromosome 6 Open Reading Frame 63 2
  • NHS-Like Protein 1 3
  • KIAA1357 4

External Ids for NHSL1 Gene

Previous HGNC Symbols for NHSL1 Gene

  • C6orf63

Previous GeneCards Identifiers for NHSL1 Gene

  • GC06M138784
  • GC06M136304
  • GC06M138743

Summaries for NHSL1 Gene

GeneCards Summary for NHSL1 Gene

NHSL1 (NHS Like 1) is a Protein Coding gene. Diseases associated with NHSL1 include Nance-Horan Syndrome. An important paralog of this gene is NHS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHSL1 Gene

Genomics for NHSL1 Gene

Regulatory Elements for NHSL1 Gene

Enhancers for NHSL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F138548 0.8 ENCODE 28.5 +144.1 144098 0.4 NHSL1 FLJ46906 ENSG00000274594 LOC100129577
GH06F138549 0.2 ENCODE 27.6 +142.4 142374 1.3 HDGF MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 MXD4 MIER2 NHSL1 FLJ46906 ENSG00000274594 LOC100129577
GH06F138535 1 FANTOM5 Ensembl ENCODE 26.6 +150.9 150892 12.8 PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ZNF121 SLC30A9 FOS NHSL1 FLJ46906 PERP HEBP2 PBOV1 ENSG00000274594 LOC100129577
GH06F138591 1 Ensembl ENCODE 17.8 +98.5 98532 5.0 ARID4B DMAP1 ZNF48 SLC30A9 FOS ZNF263 SP5 JUNB PPARG TBX21 FLJ46906 NHSL1 CCDC28A PERP LOC100129577 ENSG00000274594
GH06F138588 1.1 Ensembl ENCODE 16.2 +103.6 103616 0.4 ELF3 WRNIP1 ARID4B ZSCAN9 ZNF2 RAD21 ZNF366 ZNF143 EGR2 ZNF654 NHSL1 FLJ46906 PERP LOC100129577 ENSG00000274594
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NHSL1 on UCSC Golden Path with GeneCards custom track

Promoters for NHSL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001228657 15 3199 PKNOX1 ARID4B SIN3A ZNF48 ZNF2 YY1 SLC30A9 GLIS2 ZNF143 ZNF263

Genomic Location for NHSL1 Gene

138,422,043 bp from pter
138,692,616 bp from pter
270,574 bases
Minus strand

Genomic View for NHSL1 Gene

Genes around NHSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHSL1 Gene

Proteins for NHSL1 Gene

  • Protein details for NHSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NHS-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q3ZCS5
    • Q5SYE8
    • Q9P2J0

    Protein attributes for NHSL1 Gene

    1610 amino acids
    Molecular mass:
    170668 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI12098.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12099.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14156.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14157.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NHSL1 Gene


neXtProt entry for NHSL1 Gene

Post-translational modifications for NHSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NHSL1 Gene

Domains & Families for NHSL1 Gene

Protein Domains for NHSL1 Gene


Suggested Antigen Peptide Sequences for NHSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NHS family.
  • Belongs to the NHS family.
genes like me logo Genes that share domains with NHSL1: view

No data available for Gene Families for NHSL1 Gene

Function for NHSL1 Gene

Phenotypes for NHSL1 Gene

genes like me logo Genes that share phenotypes with NHSL1: view

Animal Models for NHSL1 Gene

MGI Knock Outs for NHSL1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NHSL1 Gene

Localization for NHSL1 Gene

Subcellular locations from

Jensen Localization Image for NHSL1 Gene COMPARTMENTS Subcellular localization image for NHSL1 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NHSL1 Gene

Pathways & Interactions for NHSL1 Gene

SuperPathways for NHSL1 Gene

No Data Available

Interacting Proteins for NHSL1 Gene

Selected Interacting proteins: Q5SYE7-NHSL1_HUMAN for NHSL1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NHSL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for NHSL1 Gene

Transcripts for NHSL1 Gene

Unigene Clusters for NHSL1 Gene

NHS-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHSL1 Gene

No ASD Table

Relevant External Links for NHSL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NHSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NHSL1 Gene

This gene is overexpressed in Plasma (47.0) and Placenta (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NHSL1 Gene

Protein tissue co-expression partners for NHSL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NHSL1 Gene:


SOURCE GeneReport for Unigene cluster for NHSL1 Gene:


mRNA Expression by UniProt/SwissProt for NHSL1 Gene:

Tissue specificity: Widely expressed. Expressed in adult and fetal brain, fetal eyes, adult lens, kidney, liver and intestine.
genes like me logo Genes that share expression patterns with NHSL1: view

Primer Products

No data available for mRNA differential expression in normal tissues for NHSL1 Gene

Orthologs for NHSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHSL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NHSL1 34 35
  • 98.96 (n)
(Canis familiaris)
Mammalia NHSL1 34 35
  • 83.7 (n)
(Bos Taurus)
Mammalia NHSL1 34 35
  • 82.58 (n)
(Mus musculus)
Mammalia Nhsl1 34 16 35
  • 81.17 (n)
(Rattus norvegicus)
Mammalia Nhsl1 34
  • 80.42 (n)
(Monodelphis domestica)
Mammalia NHSL1 35
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
-- 35
  • 51 (a)
(Gallus gallus)
Aves NHSL1 35
  • 51 (a)
(Anolis carolinensis)
Reptilia NHSL1 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nhsl1 34
  • 54.57 (n)
(Danio rerio)
Actinopterygii nhsl1b 34 35
  • 60.01 (n)
nhsl1a 35
  • 34 (a)
Species where no ortholog for NHSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHSL1 Gene

Gene Tree for NHSL1 (if available)
Gene Tree for NHSL1 (if available)

Paralogs for NHSL1 Gene

Paralogs for NHSL1 Gene

genes like me logo Genes that share paralogs with NHSL1: view

Variants for NHSL1 Gene

Sequence variations from dbSNP and Humsavar for NHSL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10046311 -- 138,495,141(+) agaag(A/G)ctgag intron-variant
rs10080583 -- 138,558,708(+) gctac(A/G)gtgcc intron-variant
rs10081050 -- 138,558,616(+) acagg(A/G)tttca intron-variant
rs10085225 -- 138,622,794(+) TGGTA(A/C)ACCAG intron-variant
rs10085294 -- 138,620,950(+) ACTGC(A/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NHSL1 Gene

Variant ID Type Subtype PubMed ID
esv1934223 CNV deletion 18987734
esv2399126 CNV deletion 18987734
esv2469347 CNV deletion 19546169
esv2732769 CNV deletion 23290073
esv2732770 CNV deletion 23290073
esv2732771 CNV deletion 23290073
esv2752090 CNV gain 17911159
esv3610957 CNV loss 21293372
nsv1117668 CNV deletion 24896259
nsv1124122 CNV deletion 24896259
nsv5499 CNV deletion 18451855

Variation tolerance for NHSL1 Gene

Gene Damage Index Score: 4.65; 65.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NHSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHSL1 Gene

Disorders for NHSL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NHSL1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nance-horan syndrome
  • cataract dental syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NHSL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NHSL1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NHSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NHSL1 Gene

Publications for NHSL1 Gene

  1. Identification of the gene for Nance-Horan syndrome (NHS). (PMID: 15466011) Brooks S.P. … Hardcastle A.J. (J. Med. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for NHSL1 Gene

Sources for NHSL1 Gene

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