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Aliases for NHSL1 Gene

Aliases for NHSL1 Gene

  • NHS-Like 1 2 3
  • C6orf63 3 4
  • Chromosome 6 Open Reading Frame 63 2
  • NHS-Like Protein 1 3
  • KIAA1357 4

External Ids for NHSL1 Gene

Previous Symbols for NHSL1 Gene

  • C6orf63

Summaries for NHSL1 Gene

GeneCards Summary for NHSL1 Gene

NHSL1 (NHS-Like 1) is a Protein Coding gene. Diseases associated with NHSL1 include nance-horan syndrome. An important paralog of this gene is NHS.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHSL1 Gene

Genomics for NHSL1 Gene

Genomic Location for NHSL1 Gene

Start:
138,422,043 bp from pter
End:
138,692,571 bp from pter
Size:
270,529 bases
Orientation:
Minus strand

Genomic View for NHSL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NHSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHSL1 Gene

Regulatory Elements for NHSL1 Gene

Proteins for NHSL1 Gene

  • Protein details for NHSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SYE7-NHSL1_HUMAN
    Recommended name:
    NHS-like protein 1
    Protein Accession:
    Q5SYE7
    Secondary Accessions:
    • Q3ZCS5
    • Q5SYE8
    • Q9P2J0

    Protein attributes for NHSL1 Gene

    Size:
    1610 amino acids
    Molecular mass:
    170668 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12098.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12099.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14156.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14157.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NHSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NHSL1 Gene

Proteomics data for NHSL1 Gene at MOPED

Post-translational modifications for NHSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NHSL1 Gene

No data available for DME Specific Peptides for NHSL1 Gene

Domains for NHSL1 Gene

Protein Domains for NHSL1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NHSL1_HUMAN
Family:
  • Belongs to the NHS family.:
    • Q5SYE7
genes like me logo Genes that share domains with NHSL1: view

No data available for Gene Families for NHSL1 Gene

Function for NHSL1 Gene

Phenotypes for NHSL1 Gene

GenomeRNAi human phenotypes for NHSL1:
genes like me logo Genes that share phenotypes with NHSL1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for NHSL1 Gene

Localization for NHSL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NHSL1 Gene COMPARTMENTS Subcellular localization image for NHSL1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for NHSL1 Gene

Pathways for NHSL1 Gene

SuperPathways for NHSL1 Gene

No Data Available

Interacting Proteins for NHSL1 Gene

Gene Ontology (GO) - Biological Process for NHSL1 Gene

None

No data available for Pathways by source for NHSL1 Gene

Transcripts for NHSL1 Gene

Unigene Clusters for NHSL1 Gene

NHS-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NHSL1 Gene

No ASD Table

Relevant External Links for NHSL1 Gene

GeneLoc Exon Structure for
NHSL1
ECgene alternative splicing isoforms for
NHSL1

Expression for NHSL1 Gene

mRNA expression in normal human tissues for NHSL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NHSL1 Gene

SOURCE GeneReport for Unigene cluster for NHSL1 Gene Hs.652741

mRNA Expression by UniProt/SwissProt for NHSL1 Gene

Q5SYE7-NHSL1_HUMAN
Tissue specificity: Widely expressed. Expressed in adult and fetal brain, fetal eyes, adult lens, kidney, liver and intestine.
genes like me logo Genes that share expressions with NHSL1: view

Orthologs for NHSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NHSL1 36
  • 98.96 (n)
  • 98.06 (a)
NHSL1 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NHSL1 36
  • 82.58 (n)
  • 79.34 (a)
NHSL1 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NHSL1 36
  • 83.7 (n)
  • 80.8 (a)
NHSL1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nhsl1 36
  • 81.17 (n)
  • 77.58 (a)
Nhsl1 16
Nhsl1 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NHSL1 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 51 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nhsl1 36
  • 80.42 (n)
  • 76.44 (a)
chicken
(Gallus gallus)
Aves NHSL1 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NHSL1 37
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nhsl1 36
  • 54.57 (n)
  • 49.84 (a)
zebrafish
(Danio rerio)
Actinopterygii nhsl1a 37
  • 34 (a)
OneToMany
nhsl1b 36
  • 60.01 (n)
  • 56.28 (a)
nhsl1b 37
  • 38 (a)
OneToMany
Species with no ortholog for NHSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHSL1 Gene

ENSEMBL:
Gene Tree for NHSL1 (if available)
TreeFam:
Gene Tree for NHSL1 (if available)

Paralogs for NHSL1 Gene

Paralogs for NHSL1 Gene

genes like me logo Genes that share paralogs with NHSL1: view

Variants for NHSL1 Gene

Sequence variations from dbSNP and Humsavar for NHSL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs726621 -- 138,428,529(+) CTTTA(A/G)GATCT intron-variant
rs1074600 -- 138,471,747(-) CATTT(A/G)AAATT intron-variant
rs1467701 -- 138,472,404(-) CCAGG(C/T)ATTGT intron-variant
rs1556108 -- 138,455,758(-) TGCTA(G/T)TGCTA intron-variant
rs1556109 -- 138,455,756(-) CTATT(G/T)CTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NHSL1 Gene

Variant ID Type Subtype PubMed ID
esv2752090 CNV Gain 17911159
esv2469347 CNV Deletion 19546169
esv2732769 CNV Deletion 23290073
esv2399126 CNV Deletion 18987734
esv2732770 CNV Deletion 23290073
esv2732771 CNV Deletion 23290073
nsv5499 CNV Loss 18451855
esv1934223 CNV Deletion 18987734

Relevant External Links for NHSL1 Gene

HapMap Linkage Disequilibrium report
NHSL1

Disorders for NHSL1 Gene

(1) MalaCards Diseases for NHSL1 Gene

Search for NHSL1 Gene in MalaCards »

Relevant External Links for NHSL1

Genetic Association Database (GAD)
NHSL1
genes like me logo Genes that share disorders with NHSL1: view

No data available for UniProtKB/Swiss-Prot for NHSL1 Gene

Publications for NHSL1 Gene

  1. Identification of the gene for Nance-Horan syndrome (NHS). (PMID: 15466011) Brooks S.P. … Hardcastle A.J. (J. Med. Genet. 2004) 3 4
  2. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 49
  3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for NHSL1 Gene

Sources for NHSL1 Gene

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