Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NHP2L1 Gene

protein-coding   GIFtS: 62
GCID: GC22M042069

NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)

(Previous names: non-histone chromosome protein 2 (S. cerevisiae)-like 1,...)
(Previous symbol: SSFA1)
 Explore 4 diseases affiliated with
NHP2L1 via our new
 Human Malady Compendium 
Biological research products
for NHP2L1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NHP2 Non-Histone Chromosome Protein 2-Like 1 (S. Cerevisiae)1 2     U4/U6.U5 Tri-SnRNP 15.5 KDa Protein2 3
15.5K1 2     Non-Histone Chromosome Protein 2 (S. Cerevisiae)-Like 11
FA-11 2     FA12
SNRNP15-51 2     NHPX2
SNU131 2     [U4/U6.U5] Tri-SnRNP 15.5 KD RNA Binding Protein2
SPAG121 2     NHP2-Like Protein 12
SSFA11 2     Non-Histone Chromosome Protein 2-Like 12
Sperm Specific Antigen 11 2     Small Nuclear Ribonucleoprotein 15.5kDa (U4/U6.U5)2
High Mobility Group-Like Nuclear Protein 2 Homolog 12 3     HSNU131
OTK272 3     SNU13 Homolog3

External Ids:    HGNC: 78191   Entrez Gene: 48092   Ensembl: ENSG000001001387   OMIM: 6013045   UniProtKB: P557693   

Export aliases for NHP2L1 gene to outside databases

Previous GC identifers: GC22M038684 GC22M040312 GC22M040394 GC22M025035


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NHP2L1:
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this
protein appears to be a highly conserved nuclear protein that is a component of the (U4/U6.U5) tri-snRNP. It binds to
the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NH2L1_HUMAN, P55769
Function: Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The
protein undergoes a conformational change upon RNA-binding

Gene Wiki entry for NHP2L1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NHP2L1 gene promoter:
         STAT1   AML1a   HSF1 (long)   HSF1short   CUTL1   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NHP2L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NHP2L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHP2L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13

NHP2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NHP2L1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M042069:  view genomic region     (about GC identifiers)

Start:
42,069,934 bp from pter      End:
42,086,508 bp from pter
Size:
16,575 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NH2L1_HUMAN, P55769 (See protein sequence)
Recommended Name: NHP2-like protein 1  
Size: 128 amino acids; 14174 Da
Subunit: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4,
PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39.
Interacts with RAD17 and PRPF31
Subcellular location: Nucleus, nucleolus. Note=Concentrated in the dense fibrillar component of the nucleolus
5 PDB 3D structures from and Proteopedia for NHP2L1:
1E7K (3D)        2JNB (3D)        2OZB (3D)        3SIU (3D)        3SIV (3D)    

Explore the universe of human proteins at neXtProt for NHP2L1: NX_P55769

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55769

  • NHP2L1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001003796.1  NP_004999.1  

    ENSEMBL proteins: 
     ENSP00000347401   ENSP00000215956   ENSP00000383949   ENSP00000383989  
    Reactome Protein details: P55769
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): NHP2L1
    OriGene Protein Over-expression Lysate (see all 2): NHP2L1
    OriGene Custom Protein Services for NHP2L1 
    GenScript Custom Purified and Recombinant Proteins Services for NHP2L1
    Novus Biologicals NHP2L1 Proteins
    Novus Biologicals NHP2L1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NHP2L1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8978773
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IEA--
    GO:0005730nucleolus TAS10593953
    GO:0030529ribonucleoprotein complex ----


    NHP2L1 for ontologies           About GeneDecksing



    NHP2L1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: NHP2L1
    OriGene Custom Antibody Services for NHP2L1 
    GenScript Custom Superior Antibodies Services for NHP2L1
    Novus Biologicals NHP2L1 Antibodies
    Search for Antibodies for NHP2L1 at Abcam  
    Uscn Antibodies for NHP2L1
    ThermoFisher Antibody for NHP2L1

    Assay Products for NHP2L1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NHP2L1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NHP2L1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NHP2L1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018492 Ribosomal_L7Ae/L8/Nhp2
     IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
     IPR004037 Ribosomal_L7Ae_CS
     IPR002415 H/ACA_rnp_Nhp2_euk

    Graphical View of Domain Structure for InterPro Entry P55769

    ProtoNet protein and cluster: P55769

    2 Blocks protein families:
    IPB002415 High mobility group-like nuclear protein signature
    IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45


    UniProtKB/Swiss-Prot: NH2L1_HUMAN, P55769
    Similarity: Belongs to the ribosomal protein L7Ae family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NH2L1_HUMAN, P55769
    Function: Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The
    protein undergoes a conformational change upon RNA-binding

         Genatlas biochemistry entry for NHP2L1:
    yeast nuclear protein NHP2 homolog

    miRNA
    Products:
        
    miRTarBase miRNAs that target NHP2L1:
    kshv-mir-k12-3 (MIRT005469)

    OriGene 3'-UTR Clone (see all 2): NHP2L1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NHP2L1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NHP2L1:
    hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidNHP2L1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHP2L1 (see all 7)
    OriGene shRNA RFP: NHP2L1
    OriGene siRNA: NHP2L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHP2L1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NHP2L1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHP2L1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHP2L1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NHP2L1 (NM_005008)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NHP2L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHP2L1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NHP2L1
    Search LifeMap BioReagents cell lines for NHP2L1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHP2L1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS10593953
    GO:0005515protein binding IPI17412961
    GO:0030515contributes to snoRNA binding IDA17636026


    NHP2L1 for ontologies           About GeneDecksing


    9 GenomeRNAi human phenotypes for NHP2L1:
     Cell cycle / mitosis defect  Decreased cell number, increas  Decreased homologous recombina  Decreased influenza A virus in 
     Decreased number of cells in m  Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    mRNA Splicing1.00
    mRNA Processing0.82
    mRNA Splicing - Major Pathway1.00
    mRNA Splicing - Minor Pathway0.40
    Processing of Capped Intron-Containing Pre-mRNA0.96
    Spliceosome0.31
    2Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes1.00
    3Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for NHP2L1 (see all 6)
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    mRNA Splicing - Minor Pathway


    2         Kegg Pathways  (Kegg details for NHP2L1):
        Ribosome biogenesis in eukaryotes
    Spliceosome


    NHP2L1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NHP2L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/251 Interacting proteins for NHP2L1 (P557691, 2, 3 ENSP000002159564) via UniProtKB, MINT, STRING, and/or I2D (see all 251)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0042254ribosome biogenesis IEA--


    NHP2L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NHP2L1

    3 DrugBank Compounds for NHP2L1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ANISOMYCIN-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    PUROMYCIN-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about NHP2L1 / NH2L1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NHP2L1 gene (2 alternative transcripts): 
    NM_001003796.1  NM_005008.3  

    Unigene Cluster for NHP2L1:

    NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
    Hs.182255  [show with all ESTs]
    Unigene Representative Sequence: AK124020
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355257(uc003bav.3) ENST00000215956(uc003bat.3) ENST00000401959
    ENST00000463675 ENST00000402458 ENST00000488571 ENST00000469028 ENST00000469522


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): NHP2L1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NHP2L1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NHP2L1:
    hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidNHP2L1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHP2L1 (see all 7)
    OriGene shRNA RFP: NHP2L1
    OriGene siRNA: NHP2L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHP2L1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHP2L1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHP2L1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NHP2L1 (NM_005008)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NHP2L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHP2L1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHP2L1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NHP2L1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHP2L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHP2L1

    Additional cDNA sequence: 

    AF091076.1 AF155235.1 AK124020.1 AK311800.1 BC005358.1 BC019282.2 BC095439.1 CR456531.1 
    CR541725.1 D50420.1 L34070.1 L34071.1 

    24/35 DOTS entries (see all 35):

    DT.101969816  DT.450040  DT.99926576  DT.100738287  DT.86854047  DT.100738300  DT.100738330  DT.91694644 
    DT.100738328  DT.92455696  DT.100738297  DT.95159246  DT.100858215  DT.40124416  DT.120652701  DT.120652656 
    DT.91713952  DT.97844043  DT.100681061  DT.100856292  DT.95159128  DT.99925511  DT.120652644  DT.120652645 

    24/1011 AceView cDNA sequences (see all 1011):

    BM905760 CB155541 AA064840 BM855095 AW025465 BM556035 BM781875 CB114434 
    AI922166 BE385310 CR605954 BE336882 AW025676 BU150372 BM911676 CB109287 
    AA601565 AA554347 CB109275 BQ949047 BM853125 AI814743 F08163 AF091076 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NHP2L1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
    SP1:                    -     -     -                 -                                       
    SP2:                                                                                          
    SP3:                    -     -     -     -     -     -                                       
    SP4:                          -     -                 -                                       
    SP5:                                -     -     -     -                                       


    ECgene alternative splicing isoforms for NHP2L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NHP2L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGTATTTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NHP2L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NHP2L1

    SOURCE GeneReport for Unigene cluster: Hs.182255

    UniProtKB/Swiss-Prot: NH2L1_HUMAN, P55769
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for NHP2L1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHP2L1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NHP2L1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHP2L1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHP2L1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHP2L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NHP2L1 gene from 8/40 species (see all 40)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NHP2L11 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) 79.43(n)
    92.97(a)
      417986  XM_416225.3  XP_416225.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia 480577342   -- 78.25(n)    48057734 
    zebrafish
    (Danio rerio)
    Actinopterygii BC046034.12   -- 78.87(n)   321114  BC046034.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta hoip1 , 3 mRNA splicing RNA binding3
    hoi-polloi1
    78(a)3
    72.44(n)1
    78.74(a)1
      30C53
    441731  NM_079975.31  NP_524714.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M28.51 , 3 ribosomal protein (L7AE family)3
    Protein M28.51
    77(a)3
    70.83(n)1
    77.34(a)1
      II(10657966-10658773)3
    1746451  NM_063899.41  NP_496300.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNU13(YEL026W)4
    SNU131
    RNA binding protein, part of U3 snoRNP involved in more4
    Snu13p1
    63.66(n)1
    71.31(a)1
      5(101943-102323)4
    8566871, 4  NP_010888.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G201601 U4/U6 small nuclear ribonucleoprotein SNU13 68.23(n)
    78.12(a)
      832138  NM_180525.2  NP_850856.1 
    rice
    (Oryza sativa)
    Liliopsida Os.127552 Transcribed sequence with strong similarity to protein more 74.05(n)    AU069238.1 


    ENSEMBL Gene Tree for NHP2L1 (if available)
    TreeFam Gene Tree for NHP2L1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NHP2L1 gene
    1 SIMAP similar gene for NHP2L1 using alignment to 3 protein entries:     NH2L1_HUMAN (see all proteins):
    NHP2

    NHP2L1 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for NHP2L1 (see all 8)
    PGOHUM00000239962 PGOHUM00000244988 PGOHUM00000244993 PGOHUM00000235321 PGOHUM00000263259


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/301 NCBI SNPs in NHP2L1 are shown (see all 301    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs121594121,2
    C,H,--25037697(+) GATGCG/ATACTC 1 -- ds50013Minor allele frequency- A:0.00NS EA 300
    rs614502741,2
    C,F,--25038565(+) CCACAC/ACTCAG 1 -- ut513Minor allele frequency- A:0.06WA 122
    rs584655661,2
    C,--25038652(+) AATGAC/TGAGGC 1 -- ut511Minor allele frequency- T:0.50WA 2
    rs81410351,2
    C,F,A,H,--25039240(+) TTACAC/TCATGC 1 -- us2k17Minor allele frequency- T:0.12NS EA WA NA 658
    rs9494371,2
    --25039430(+) TCGCCC/TAGGCT 1 -- us2k10--------
    rs755145781,2
    F,--25039717(+) CATAAA/GACCTA 1 -- us2k11Minor allele frequency- G:0.17WA 118
    rs790871951,2
    --25039817(+) CACATA/GGCAGG 1 -- us2k10--------
    rs170025991,2
    C,F,H,--25040157(+) ACCAGG/ACACTG 1 -- us2k112Minor allele frequency- A:0.13NA NS EA WA 1352
    rs734249541,2
    C,F,--25040287(+) AACACA/CGTTGA 1 -- us2k13Minor allele frequency- C:0.05WA 122
    rs780351621,2
    F,--25040362(+) CCAGCA/TTCTAT 1 -- us2k13Minor allele frequency- T:0.06CSA WA 122

    HapMap Linkage Disequilibrium report for NHP2L1 (42069934 - 42086508 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NHP2L1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHP2L1
    DNA2.0 Custom Variant and Variant Library Synthesis for NHP2L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NHP2L1 for disorders           About GeneDecksing

    OMIM gene information: 601304    OMIM disorders: --

    4 diseases for NHP2L1:    About MalaCards
    treacher collins syndrome    japanese encephalitis    encephalitis    malaria

    Human Genome Epidemiology (HuGE) Navigator: NHP2L1 (1 document)

    Export disorders for NHP2L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NHP2L1 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with NHP2L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2. (PubMed id 8978773)1, 2, 3, 9 Saito H.... Nakamura Y. (1996)
    2. Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. (PubMed id 17412961)1, 2 Liu S....Wahl M.C. (2007)
    3. Functional implications for a prototypical K-turn binding protein from structural and dynamical studies of 15.5K. (PubMed id 18044964)1, 2 Soss S.E. and Flynn P.F. (2007)
    4. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PubMed id 16723661)1, 2 Liu S.... Luehrmann R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    7. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    8. Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment. (PubMed id 11163207)1, 2 Vidovic I.... Ficner R. (2000)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    10. HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. (PubMed id 10593953)1, 2 Chang M.-S....Chen L.B. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4809 HGNC: 7819 AceView: NHP2L1 Ensembl:ENSG00000100138 euGenes: HUgn4809
    ECgene: NHP2L1 Kegg: 4809 H-InvDB: NHP2L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NHP2L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NHP2L1 gene:
    Search GeneIP for patents involving NHP2L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NHP2L1   OriGene shRNA RFP for NHP2L1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHP2L1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHP2L1  
     OriGene Protein Over-expression Lysate for NHP2L1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NHP2L1   OriGene 3'-UTR Clone for NHP2L1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHP2L1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHP2L1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NHP2L1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NHP2L1   OriGene Custom Protein Services for NHP2L1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NHP2L1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHP2L1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHP2L1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHP2L1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHP2L1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHP2L1
     GenScript Custom Purified and Recombinant Proteins Services for NHP2L1 GenScript cDNA clones with any tag delivered in your preferred vector for NHP2L1
     GenScript Custom Assay Services for NHP2L1 GenScript Custom Superior Antibodies Services for NHP2L1
     GenScript Custom overexpressing Cell Line Services for NHP2L1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NHP2L1 promoter
     Search Chromatin IP Primers for NHP2L1
     RT2 qPCR Primer Assay in human, mouse / rat NHP2L1
     GNC Network for NHP2L1
     SABiosciences Custom PCR Arrays for NHP2L1
     Search Tocris compounds for NHP2L1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NHP2L1 antibodies
     NHP2L1 proteins
     NHP2L1 lysates
     Search for Antibodies for NHP2L1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NHP2L1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NHP2L1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NHP2L1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHP2L1
     SwitchGear 3'UTR luciferase reporter plasmids for NHP2L1
     SwitchGear Promoter luciferase reporter plasmids for NHP2L1
     ThermoFisher Antibody for NHP2L1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHP2L1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NHP2L1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4