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Aliases for NHP2L1 Gene

Aliases for NHP2L1 Gene

  • NHP2 Non-Histone Chromosome Protein 2-Like 1 (S. Cerevisiae) 2 3
  • High Mobility Group-Like Nuclear Protein 2 Homolog 1 3 4
  • Small Nuclear Ribonucleoprotein 15.5kDa (U4/U6.U5) 2 3
  • U4/U6.U5 Tri-SnRNP 15.5 KDa Protein 3 4
  • Sperm Specific Antigen 1 2 3
  • OTK27 3 4
  • Non-Histone Chromosome Protein 2 (S. Cerevisiae)-Like 1 2
  • [U4/U6.U5] Tri-SnRNP 15.5 KD RNA Binding Protein 3
  • Non-Histone Chromosome Protein 2-Like 1 3
  • NHP2-Like Protein 1 3
  • SNU13 Homolog 4
  • SNRNP15-5 3
  • SPAG12 3
  • HSNU13 4
  • 15.5K 3
  • SNU13 3
  • SSFA1 3
  • FA-1 3
  • NHPX 3
  • FA1 3

External Ids for NHP2L1 Gene

Previous Symbols for NHP2L1 Gene

  • SSFA1

Summaries for NHP2L1 Gene

Entrez Gene Summary for NHP2L1 Gene

  • Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NHP2L1 Gene

NHP2L1 (NHP2 Non-Histone Chromosome Protein 2-Like 1 (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Gene Expression and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include RNA binding and snoRNA binding.

UniProtKB/Swiss-Prot for NHP2L1 Gene

  • Binds to the 5-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

Gene Wiki entry for NHP2L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHP2L1 Gene

Genomics for NHP2L1 Gene

Genomic Location for NHP2L1 Gene

Start:
41,673,930 bp from pter
End:
41,690,504 bp from pter
Size:
16,575 bases
Orientation:
Minus strand

Genomic View for NHP2L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NHP2L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHP2L1 Gene

Regulatory Elements for NHP2L1 Gene

Proteins for NHP2L1 Gene

  • Protein details for NHP2L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55769-NH2L1_HUMAN
    Recommended name:
    NHP2-like protein 1
    Protein Accession:
    P55769
    Secondary Accessions:

    Protein attributes for NHP2L1 Gene

    Size:
    128 amino acids
    Molecular mass:
    14174 Da
    Quaternary structure:
    • Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31.

    Three dimensional structures from OCA and Proteopedia for NHP2L1 Gene

neXtProt entry for NHP2L1 Gene

Proteomics data for NHP2L1 Gene at MOPED

Post-translational modifications for NHP2L1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9, Lys21, Lys33, and Lys113

Other Protein References for NHP2L1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NHP2L1 Gene

Domains for NHP2L1 Gene

UniProtKB/Swiss-Prot:

NH2L1_HUMAN
Family:
  • Belongs to the ribosomal protein L7Ae family.:
    • P55769
genes like me logo Genes that share domains with NHP2L1: view

No data available for Gene Families for NHP2L1 Gene

Function for NHP2L1 Gene

Molecular function for NHP2L1 Gene

GENATLAS Biochemistry: yeast nuclear protein NHP2 homolog
UniProtKB/Swiss-Prot Function: Binds to the 5-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

Gene Ontology (GO) - Molecular Function for NHP2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 10593953
GO:0005515 protein binding IPI 17412961
GO:0030515 contributes_to snoRNA binding IDA 17636026
GO:0030621 U4 snRNA binding IDA 11081632
GO:0034511 U3 snoRNA binding IDA 11081632
genes like me logo Genes that share ontologies with NHP2L1: view
genes like me logo Genes that share phenotypes with NHP2L1: view

miRNA for NHP2L1 Gene

miRTarBase miRNAs that target NHP2L1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NHP2L1 Gene

Localization for NHP2L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NHP2L1 Gene

Nucleus, nucleolus. Note=Concentrated in the dense fibrillar component of the nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NHP2L1 Gene COMPARTMENTS Subcellular localization image for NHP2L1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NHP2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8978773
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005730 nucleolus TAS 10593953
GO:0030529 ribonucleoprotein complex --
genes like me logo Genes that share ontologies with NHP2L1: view

Pathways for NHP2L1 Gene

genes like me logo Genes that share pathways with NHP2L1: view

Gene Ontology (GO) - Biological Process for NHP2L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with NHP2L1: view

Compounds for NHP2L1 Gene

(3) Drugbank Compounds for NHP2L1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
target
ANISOMYCIN
target
PUROMYCIN
target
genes like me logo Genes that share compounds with NHP2L1: view

Transcripts for NHP2L1 Gene

Unigene Clusters for NHP2L1 Gene

NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NHP2L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - - -
SP2:
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6:

Relevant External Links for NHP2L1 Gene

GeneLoc Exon Structure for
NHP2L1
ECgene alternative splicing isoforms for
NHP2L1

Expression for NHP2L1 Gene

mRNA expression in normal human tissues for NHP2L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NHP2L1 Gene

SOURCE GeneReport for Unigene cluster for NHP2L1 Gene Hs.182255

mRNA Expression by UniProt/SwissProt for NHP2L1 Gene

P55769-NH2L1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with NHP2L1: view

Orthologs for NHP2L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NHP2L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NHP2L1 36
  • 98.96 (n)
  • 100 (a)
NHP2L1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NHP2L1 36
  • 90.62 (n)
  • 100 (a)
NHP2L1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NHP2L1 36
  • 93.75 (n)
  • 100 (a)
NHP2L1 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5616 37
  • 100 (a)
OneToMany
Nhp2l1 36
  • 89.84 (n)
  • 100 (a)
Nhp2l1 16
Nhp2l1 37
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NHP2L1 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NHP2L1 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nhp2l1 36
  • 89.32 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves NHP2L1 36
  • 79.27 (n)
  • 92.91 (a)
NHP2L1 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NHP2L1 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75724 36
nhp2l1 36
  • 77.86 (n)
  • 92.19 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8678 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
nhp2l1a 37
  • 90 (a)
OneToMany
nhp2l1b 36
  • 78.12 (n)
  • 90.62 (a)
nhp2l1b 37
  • 91 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008163 36
  • 72.58 (n)
  • 83.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta hoip 36
  • 72.44 (n)
  • 78.74 (a)
hoip 37
  • 76 (a)
OneToOne
hoip 38
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea M28.5 36
  • 70.83 (n)
  • 77.34 (a)
M28.5 37
  • 77 (a)
OneToOne
M28.5 38
  • 77 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL070W 36
  • 65.3 (n)
  • 71.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNU13 36
  • 63.66 (n)
  • 71.31 (a)
SNU13 37
  • 69 (a)
OneToOne
SNU13 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22529g 36
  • 63.11 (n)
  • 70.49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G20160 36
  • 68.23 (n)
  • 78.12 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12809 36
corn
(Zea mays)
Liliopsida Zm.2052 36
rice
(Oryza sativa)
Liliopsida Os.12755 36
Os03g0241200 36
  • 69.53 (n)
  • 78.12 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.12661 36
bread mold
(Neurospora crassa)
Ascomycetes NCU01331 36
  • 62.68 (n)
  • 60.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes snu13 36
  • 63.69 (n)
  • 76.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4606 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5606 37
  • 78 (a)
OneToOne
Species with no ortholog for NHP2L1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NHP2L1 Gene

ENSEMBL:
Gene Tree for NHP2L1 (if available)
TreeFam:
Gene Tree for NHP2L1 (if available)

Paralogs for NHP2L1 Gene

Selected SIMAP similar genes for NHP2L1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NHP2L1: view

No data available for Paralogs for NHP2L1 Gene

Variants for NHP2L1 Gene

Sequence variations from dbSNP and Humsavar for NHP2L1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs8779 -- 41,674,272(-) GAGGC(A/G)GCCTG utr-variant-3-prime
rs13149 -- 41,674,808(-) ATCTG(A/G)TTTCT utr-variant-3-prime
rs132806 -- 41,674,789(+) AAAAA(C/T)AACAC utr-variant-3-prime
rs132807 -- 41,675,580(+) CTGTG(C/T)TTAGC intron-variant
rs949437 -- 41,678,018(+) TCGCC(C/T)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NHP2L1 Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv834209 CNV Loss 17160897
nsv915155 CNV Loss 21882294

Relevant External Links for NHP2L1 Gene

HapMap Linkage Disequilibrium report
NHP2L1

Disorders for NHP2L1 Gene

Relevant External Links for NHP2L1

Genetic Association Database (GAD)
NHP2L1
Human Genome Epidemiology (HuGE) Navigator
NHP2L1
genes like me logo Genes that share disorders with NHP2L1: view

No data available for UniProtKB/Swiss-Prot for NHP2L1 Gene

Publications for NHP2L1 Gene

  1. Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2. (PMID: 8978773) Saito H. … Nakamura Y. (Cytogenet. Cell Genet. 1996) 2 3 4 23
  2. Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA. (PMID: 10545122) Nottrott S. … Luehrmann R. (EMBO J. 1999) 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. (PMID: 10593953) Chang M.-S. … Chen L.B. (J. Biol. Chem. 1999) 3 4
  5. Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment. (PMID: 11163207) Vidovic I. … Ficner R. (Mol. Cell 2000) 3 4

Products for NHP2L1 Gene

Sources for NHP2L1 Gene

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