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Aliases for NHLRC4 Gene

Aliases for NHLRC4 Gene

  • NHL Repeat Containing 4 2 3 5

External Ids for NHLRC4 Gene

Previous GeneCards Identifiers for NHLRC4 Gene

  • GC16P000558
  • GC16P000612
  • GC16P000614

Summaries for NHLRC4 Gene

GeneCards Summary for NHLRC4 Gene

NHLRC4 (NHL Repeat Containing 4) is a Protein Coding gene. An important paralog of this gene is TRIM32.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLRC4 Gene

Genomics for NHLRC4 Gene

Regulatory Elements for NHLRC4 Gene

Enhancers for NHLRC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000523 1.5 FANTOM5 ENCODE 14.2 -39.2 -39204 7.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NHLRC4 JMJD8 PRR35 PIGQ ENSG00000261505 MPG LOC105371038 TPSG1 ENSG00000260022 ENSG00000260051
GH16F000456 1.4 FANTOM5 Ensembl ENCODE 14.8 -109.2 -109239 2.3 HDAC1 TBL1XR1 GATA2 SCRT2 EGR2 ZNF263 PPARG KLF16 SMARCA4 PBX2 DECR2 NME4 NHLRC4 PRR35 PIGQ ENSG00000230428 GC16P000492
GH16F000586 1.5 FANTOM5 ENCODE 12.6 +24.1 24137 8.4 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 WFIKKN1 RAB40C LOC105371038 ENSG00000261505 HBZP1 PRSS29P ENSG00000260051 ENSG00000260022 ENSG00000260954 NHLRC4
GH16F000329 1.6 FANTOM5 Ensembl ENCODE 10.3 -235.6 -235555 3.1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 ZNF263 SP3 MXD4 TMEM8A NHLRC4 MRPL28 ARHGDIG NME4 AXIN1 HAGHL PIR38678 GC16P000365
GH16F000533 1.2 Ensembl ENCODE 13 -32.1 -32094 3.2 PKNOX1 ZFP64 ARID4B DMAP1 ZNF2 ZNF48 YY1 GLIS2 KLF7 FOS CAPN15 PRR35 NHLRC4 PIGQ NME4 DECR2 MIR5587 GC16M000522
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NHLRC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NHLRC4 Gene

Chromosome:
16
Start:
566,995 bp from pter
End:
569,495 bp from pter
Size:
2,501 bases
Orientation:
Plus strand

Genomic View for NHLRC4 Gene

Genes around NHLRC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHLRC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHLRC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLRC4 Gene

Proteins for NHLRC4 Gene

  • Protein details for NHLRC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG21-NHLC4_HUMAN
    Recommended name:
    NHL-repeat-containing protein 4
    Protein Accession:
    P0CG21
    Secondary Accessions:
    • B8ZZ27
    • Q8N233
    • Q96AX3
    • Q96S23

    Protein attributes for NHLRC4 Gene

    Size:
    123 amino acids
    Molecular mass:
    12631 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NHLRC4 Gene

Post-translational modifications for NHLRC4 Gene

No Post-translational modifications

Other Protein References for NHLRC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NHLRC4 Gene

Domains & Families for NHLRC4 Gene

Protein Domains for NHLRC4 Gene

Suggested Antigen Peptide Sequences for NHLRC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG21

UniProtKB/Swiss-Prot:

NHLC4_HUMAN :
  • Contains 2 NHL repeats.
Similarity:
  • Contains 2 NHL repeats.
genes like me logo Genes that share domains with NHLRC4: view

No data available for Gene Families for NHLRC4 Gene

Function for NHLRC4 Gene

Phenotypes for NHLRC4 Gene

GenomeRNAi human phenotypes for NHLRC4:
genes like me logo Genes that share phenotypes with NHLRC4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NHLRC4 Gene

Localization for NHLRC4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NHLRC4 Gene

Pathways & Interactions for NHLRC4 Gene

SuperPathways for NHLRC4 Gene

No Data Available

Interacting Proteins for NHLRC4 Gene

Gene Ontology (GO) - Biological Process for NHLRC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NHLRC4 Gene

Transcripts for NHLRC4 Gene

mRNA/cDNA for NHLRC4 Gene

Unigene Clusters for NHLRC4 Gene

NHL repeat containing 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHLRC4 Gene

No ASD Table

Relevant External Links for NHLRC4 Gene

GeneLoc Exon Structure for
NHLRC4
ECgene alternative splicing isoforms for
NHLRC4

Expression for NHLRC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NHLRC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NHLRC4 Gene:

NHLRC4

SOURCE GeneReport for Unigene cluster for NHLRC4 Gene:

Hs.664267
genes like me logo Genes that share expression patterns with NHLRC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NHLRC4 Gene

Orthologs for NHLRC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHLRC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC618053 34
  • 80.05 (n)
NHLRC4 35
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nhlrc4 34 16 35
  • 79.67 (n)
dog
(Canis familiaris)
Mammalia NHLRC4 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves NHLRC4 35
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NHLRC4 35
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734263 34
  • 57.68 (n)
Species where no ortholog for NHLRC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NHLRC4 Gene

ENSEMBL:
Gene Tree for NHLRC4 (if available)
TreeFam:
Gene Tree for NHLRC4 (if available)

Paralogs for NHLRC4 Gene

Paralogs for NHLRC4 Gene

genes like me logo Genes that share paralogs with NHLRC4: view

Variants for NHLRC4 Gene

Sequence variations from dbSNP and Humsavar for NHLRC4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111721659 -- 567,207(+) GTGAC(C/T)GCCCC intron-variant
rs113068385 -- 565,048(+) GGGGC(A/G)GCCCG upstream-variant-2KB, reference, missense
rs113099841 -- 565,076(+) ACCGG(A/G)GGCAC upstream-variant-2KB, reference, synonymous-codon
rs113227275 -- 567,377(+) TGGCC(A/G/T)CTGGG intron-variant
rs113324364 -- 567,890(+) AGCCC(A/G)GGACC utr-variant-3-prime, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NHLRC4 Gene

Variant ID Type Subtype PubMed ID
nsv952898 CNV deletion 24416366
nsv833114 CNV gain+loss 17160897
nsv833113 CNV loss 17160897
nsv571006 CNV gain 21841781
nsv570988 CNV gain 21841781
nsv528354 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv471064 CNV gain 18288195
nsv471063 CNV loss 18288195
nsv457304 CNV gain 19166990
nsv1160325 CNV duplication 26073780
esv2422427 CNV duplication 17116639
dgv4823n54 CNV loss 21841781

Variation tolerance for NHLRC4 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NHLRC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NHLRC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHLRC4 Gene

Disorders for NHLRC4 Gene

Relevant External Links for NHLRC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NHLRC4

No disorders were found for NHLRC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NHLRC4 Gene

Publications for NHLRC4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for NHLRC4 Gene

Sources for NHLRC4 Gene

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