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Aliases for NHLRC3 Gene

Aliases for NHLRC3 Gene

  • NHL Repeat Containing 3 2 3 5

External Ids for NHLRC3 Gene

Previous GeneCards Identifiers for NHLRC3 Gene

  • GC13P038512
  • GC13P039612
  • GC13P020412

Summaries for NHLRC3 Gene

Entrez Gene Summary for NHLRC3 Gene

  • This gene encodes a protein containing NCL-1, HT2A and Lin-41 (NHL) family repeats. Mammalian NHL-repeat containing proteins may be involved in a variety of enzymatic processes, including protein modification through ubiquitination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for NHLRC3 Gene

NHLRC3 (NHL Repeat Containing 3) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLRC3 Gene

Genomics for NHLRC3 Gene

Regulatory Elements for NHLRC3 Gene

Enhancers for NHLRC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NHLRC3 on UCSC Golden Path with GeneCards custom track

Promoters for NHLRC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NHLRC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NHLRC3 Gene

39,038,306 bp from pter
39,050,109 bp from pter
11,804 bases
Plus strand

Genomic View for NHLRC3 Gene

Genes around NHLRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHLRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLRC3 Gene

Proteins for NHLRC3 Gene

  • Protein details for NHLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NHL repeat-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B2RTZ2
    • B4DTL0
    • Q69YI9

    Protein attributes for NHLRC3 Gene

    347 amino acids
    Molecular mass:
    38283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NHLRC3 Gene


neXtProt entry for NHLRC3 Gene

Proteomics data for NHLRC3 Gene at MOPED

Post-translational modifications for NHLRC3 Gene

  • Ubiquitination at Lys 86
  • Glycosylation at Asn 32, Asn 101, Asn 206, and Asn 278
  • Modification sites at PhosphoSitePlus

Other Protein References for NHLRC3 Gene

No data available for DME Specific Peptides for NHLRC3 Gene

Domains & Families for NHLRC3 Gene

Protein Domains for NHLRC3 Gene

Suggested Antigen Peptide Sequences for NHLRC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 NHL repeats.
  • Contains 4 NHL repeats.
genes like me logo Genes that share domains with NHLRC3: view

No data available for Gene Families for NHLRC3 Gene

Function for NHLRC3 Gene

Phenotypes for NHLRC3 Gene

genes like me logo Genes that share phenotypes with NHLRC3: view

Animal Model Products

CRISPR Products

miRNA for NHLRC3 Gene

miRTarBase miRNAs that target NHLRC3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NHLRC3 Gene

Localization for NHLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NHLRC3 Gene


Subcellular locations from

Jensen Localization Image for NHLRC3 Gene COMPARTMENTS Subcellular localization image for NHLRC3 gene
Compartment Confidence
extracellular 5
lysosome 2
vacuole 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NHLRC3 Gene

Pathways & Interactions for NHLRC3 Gene

SuperPathways for NHLRC3 Gene

No Data Available

Interacting Proteins for NHLRC3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000368920 for NHLRC3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NHLRC3 Gene


No data available for Pathways by source and SIGNOR curated interactions for NHLRC3 Gene

Drugs & Compounds for NHLRC3 Gene

No Compound Related Data Available

Transcripts for NHLRC3 Gene

Unigene Clusters for NHLRC3 Gene

NHL repeat containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NHLRC3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP5: - -

Relevant External Links for NHLRC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHLRC3 Gene

mRNA expression in normal human tissues for NHLRC3 Gene

Protein differential expression in normal tissues from HIPED for NHLRC3 Gene

This gene is overexpressed in Urine (14.3), Testis (7.3), and Oral epithelium (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NHLRC3 Gene

SOURCE GeneReport for Unigene cluster for NHLRC3 Gene Hs.507783

genes like me logo Genes that share expression patterns with NHLRC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NHLRC3 Gene

Orthologs for NHLRC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NHLRC3 35
  • 86.76 (n)
  • 84.41 (a)
  • 82 (a)
(Canis familiaris)
Mammalia NHLRC3 35
  • 89.82 (n)
  • 87.61 (a)
  • 85 (a)
(Mus musculus)
Mammalia Nhlrc3 35
  • 83.19 (n)
  • 83.86 (a)
Nhlrc3 16
Nhlrc3 36
  • 84 (a)
(Pan troglodytes)
Mammalia NHLRC3 35
  • 99.9 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Nhlrc3 35
  • 82.9 (n)
  • 83.29 (a)
(Monodelphis domestica)
Mammalia NHLRC3 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia NHLRC3 36
  • 70 (a)
(Gallus gallus)
Aves NHLRC3 35
  • 68.62 (n)
  • 65.74 (a)
  • 63 (a)
(Anolis carolinensis)
Reptilia NHLRC3 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nhlrc3 35
  • 63.85 (n)
  • 59.52 (a)
(Danio rerio)
Actinopterygii NHLRC3 36
  • 53 (a)
Species with no ortholog for NHLRC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHLRC3 Gene

Gene Tree for NHLRC3 (if available)
Gene Tree for NHLRC3 (if available)

Paralogs for NHLRC3 Gene

(1) SIMAP similar genes for NHLRC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NHLRC3: view

No data available for Paralogs for NHLRC3 Gene

Variants for NHLRC3 Gene

Sequence variations from dbSNP and Humsavar for NHLRC3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs9603498 - 39,044,165(+) TACAC(G/T)TGATT nc-transcript-variant, reference, missense
rs1887111 -- 39,040,726(-) ATGTC(C/T)CTCAA intron-variant
rs2274383 -- 39,047,977(-) CACTT(A/G)GTGAA nc-transcript-variant, utr-variant-3-prime
rs2274384 -- 39,044,037(-) ATGCA(C/T)TTGCA intron-variant
rs6563665 -- 39,046,187(+) gtggc(A/G)ggcgc intron-variant

Variation tolerance for NHLRC3 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NHLRC3 Gene

Disorders for NHLRC3 Gene

Relevant External Links for NHLRC3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NHLRC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NHLRC3 Gene

Publications for NHLRC3 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NHLRC3 Gene

Sources for NHLRC3 Gene