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Aliases for NHLRC3 Gene

Aliases for NHLRC3 Gene

  • NHL Repeat Containing 3 2 3

External Ids for NHLRC3 Gene

Previous GeneCards Identifiers for NHLRC3 Gene

  • GC13P038512
  • GC13P039612
  • GC13P020412

Summaries for NHLRC3 Gene

Entrez Gene Summary for NHLRC3 Gene

  • This gene encodes a protein containing NCL-1, HT2A and Lin-41 (NHL) family repeats. Mammalian NHL-repeat containing proteins may be involved in a variety of enzymatic processes, including protein modification through ubiquitination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for NHLRC3 Gene

NHLRC3 (NHL Repeat Containing 3) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLRC3 Gene

Genomics for NHLRC3 Gene

Regulatory Elements for NHLRC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NHLRC3 Gene

Chromosome:
13
Start:
39,038,306 bp from pter
End:
39,050,109 bp from pter
Size:
11,804 bases
Orientation:
Plus strand

Genomic View for NHLRC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NHLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLRC3 Gene

Proteins for NHLRC3 Gene

  • Protein details for NHLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JS37-NHLC3_HUMAN
    Recommended name:
    NHL repeat-containing protein 3
    Protein Accession:
    Q5JS37
    Secondary Accessions:
    • B2RTZ2
    • B4DTL0
    • Q69YI9

    Protein attributes for NHLRC3 Gene

    Size:
    347 amino acids
    Molecular mass:
    38283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NHLRC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NHLRC3 Gene

Proteomics data for NHLRC3 Gene at MOPED

Post-translational modifications for NHLRC3 Gene

  • Ubiquitination at Lys 86
  • Glycosylation at Asn 32, Asn 101, Asn 206, and Asn 278
  • Modification sites at PhosphoSitePlus

Other Protein References for NHLRC3 Gene

Antibody Products

No data available for DME Specific Peptides for NHLRC3 Gene

Domains & Families for NHLRC3 Gene

Protein Domains for NHLRC3 Gene

Suggested Antigen Peptide Sequences for NHLRC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5JS37

UniProtKB/Swiss-Prot:

NHLC3_HUMAN :
  • Contains 4 NHL repeats.
Similarity:
  • Contains 4 NHL repeats.
genes like me logo Genes that share domains with NHLRC3: view

No data available for Gene Families for NHLRC3 Gene

Function for NHLRC3 Gene

Gene Ontology (GO) - Molecular Function for NHLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NHLRC3: view

Phenotypes for NHLRC3 Gene

genes like me logo Genes that share phenotypes with NHLRC3: view

Animal Model Products

CRISPR Products

miRNA for NHLRC3 Gene

miRTarBase miRNAs that target NHLRC3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NHLRC3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NHLRC3 Gene

Localization for NHLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NHLRC3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NHLRC3 Gene COMPARTMENTS Subcellular localization image for NHLRC3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for NHLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NHLRC3: view

Pathways & Interactions for NHLRC3 Gene

SuperPathways for NHLRC3 Gene

No Data Available

Interacting Proteins for NHLRC3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368920%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000368920 for NHLRC3 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for NHLRC3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NHLRC3 Gene

Drugs & Compounds for NHLRC3 Gene

No Compound Related Data Available

Transcripts for NHLRC3 Gene

Unigene Clusters for NHLRC3 Gene

NHL repeat containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NHLRC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHLRC3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4:
SP5: - -
SP6:

Relevant External Links for NHLRC3 Gene

GeneLoc Exon Structure for
NHLRC3
ECgene alternative splicing isoforms for
NHLRC3

Expression for NHLRC3 Gene

mRNA expression in normal human tissues for NHLRC3 Gene

Protein differential expression in normal tissues from HIPED for NHLRC3 Gene

This gene is overexpressed in Urine (14.3), Testis (7.3), and Oral epithelium (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NHLRC3 Gene



SOURCE GeneReport for Unigene cluster for NHLRC3 Gene Hs.507783

genes like me logo Genes that share expression patterns with NHLRC3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NHLRC3 Gene

Orthologs for NHLRC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NHLRC3 35
  • 86.76 (n)
  • 84.41 (a)
NHLRC3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NHLRC3 35
  • 89.82 (n)
  • 87.61 (a)
NHLRC3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nhlrc3 35
  • 83.19 (n)
  • 83.86 (a)
Nhlrc3 16
Nhlrc3 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NHLRC3 35
  • 99.9 (n)
  • 100 (a)
NHLRC3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nhlrc3 35
  • 82.9 (n)
  • 83.29 (a)
oppossum
(Monodelphis domestica)
Mammalia NHLRC3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NHLRC3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves NHLRC3 35
  • 68.62 (n)
  • 65.74 (a)
NHLRC3 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NHLRC3 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nhlrc3 35
  • 63.85 (n)
  • 59.52 (a)
zebrafish
(Danio rerio)
Actinopterygii NHLRC3 36
  • 53 (a)
OneToOne
Species with no ortholog for NHLRC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHLRC3 Gene

ENSEMBL:
Gene Tree for NHLRC3 (if available)
TreeFam:
Gene Tree for NHLRC3 (if available)

Paralogs for NHLRC3 Gene

(1) SIMAP similar genes for NHLRC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NHLRC3: view

No data available for Paralogs for NHLRC3 Gene

Variants for NHLRC3 Gene

Sequence variations from dbSNP and Humsavar for NHLRC3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_051233 -

Variation tolerance for NHLRC3 Gene

Residual Variation Intolerance Score: 87.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NHLRC3 Gene

HapMap Linkage Disequilibrium report
NHLRC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NHLRC3 Gene

Disorders for NHLRC3 Gene

Relevant External Links for NHLRC3

Genetic Association Database (GAD)
NHLRC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NHLRC3
genes like me logo Genes that share disorders with NHLRC3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NHLRC3 Gene

Publications for NHLRC3 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 67
  5. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 67

Products for NHLRC3 Gene

Sources for NHLRC3 Gene

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