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Aliases for NHLRC2 Gene

Aliases for NHLRC2 Gene

  • NHL Repeat Containing 2 2 3 5
  • Novel NHL Repeat Domain Containing Protein 3
  • NHL Repeat-Containing Protein 2 3
  • 1200003G01Rik 3

External Ids for NHLRC2 Gene

Previous GeneCards Identifiers for NHLRC2 Gene

  • GC10P115280
  • GC10P115604
  • GC10P109241

Summaries for NHLRC2 Gene

GeneCards Summary for NHLRC2 Gene

NHLRC2 (NHL Repeat Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLRC2 Gene

Genomics for NHLRC2 Gene

Regulatory Elements for NHLRC2 Gene

Enhancers for NHLRC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NHLRC2 on UCSC Golden Path with GeneCards custom track

Promoters for NHLRC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NHLRC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NHLRC2 Gene

Chromosome:
10
Start:
113,854,632 bp from pter
End:
113,917,194 bp from pter
Size:
62,563 bases
Orientation:
Plus strand

Genomic View for NHLRC2 Gene

Genes around NHLRC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHLRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHLRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLRC2 Gene

Proteins for NHLRC2 Gene

  • Protein details for NHLRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBF2-NHLC2_HUMAN
    Recommended name:
    NHL repeat-containing protein 2
    Protein Accession:
    Q8NBF2
    Secondary Accessions:
    • Q8N1H1
    • Q8N5A6

    Protein attributes for NHLRC2 Gene

    Size:
    726 amino acids
    Molecular mass:
    79444 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05316.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NHLRC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NHLRC2 Gene

Post-translational modifications for NHLRC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NHLRC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NHLRC2 Gene

Domains & Families for NHLRC2 Gene

Suggested Antigen Peptide Sequences for NHLRC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBF2

UniProtKB/Swiss-Prot:

NHLC2_HUMAN :
  • Contains 1 thioredoxin domain.
  • Contains 6 NHL repeats.
Domain:
  • Contains 1 thioredoxin domain.
Similarity:
  • Contains 6 NHL repeats.
genes like me logo Genes that share domains with NHLRC2: view

No data available for Gene Families for NHLRC2 Gene

Function for NHLRC2 Gene

Gene Ontology (GO) - Molecular Function for NHLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NHLRC2: view

Phenotypes for NHLRC2 Gene

genes like me logo Genes that share phenotypes with NHLRC2: view

Animal Models for NHLRC2 Gene

MGI Knock Outs for NHLRC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NHLRC2

CRISPR Products

miRNA for NHLRC2 Gene

miRTarBase miRNAs that target NHLRC2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NHLRC2 Gene

Localization for NHLRC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NHLRC2 Gene COMPARTMENTS Subcellular localization image for NHLRC2 gene
Compartment Confidence
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NHLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with NHLRC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NHLRC2 Gene

Pathways & Interactions for NHLRC2 Gene

SuperPathways for NHLRC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NHLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with NHLRC2: view

No data available for Pathways by source and SIGNOR curated interactions for NHLRC2 Gene

Drugs & Compounds for NHLRC2 Gene

No Compound Related Data Available

Transcripts for NHLRC2 Gene

mRNA/cDNA for NHLRC2 Gene

Unigene Clusters for NHLRC2 Gene

NHL repeat containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHLRC2 Gene

No ASD Table

Relevant External Links for NHLRC2 Gene

GeneLoc Exon Structure for
NHLRC2
ECgene alternative splicing isoforms for
NHLRC2

Expression for NHLRC2 Gene

mRNA expression in normal human tissues for NHLRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NHLRC2 Gene

This gene is overexpressed in Uterus (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NHLRC2 Gene



Protein tissue co-expression partners for NHLRC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NHLRC2 Gene:

NHLRC2

SOURCE GeneReport for Unigene cluster for NHLRC2 Gene:

Hs.369924
genes like me logo Genes that share expression patterns with NHLRC2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NHLRC2 Gene

Orthologs for NHLRC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NHLRC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NHLRC2 34
  • 90.13 (n)
  • 90.22 (a)
NHLRC2 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NHLRC2 34
  • 91.41 (n)
  • 90.77 (a)
NHLRC2 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nhlrc2 34
  • 82.57 (n)
  • 84 (a)
Nhlrc2 16
Nhlrc2 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NHLRC2 34
  • 99.4 (n)
  • 99.04 (a)
NHLRC2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nhlrc2 34
  • 81.15 (n)
  • 83.72 (a)
oppossum
(Monodelphis domestica)
Mammalia NHLRC2 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NHLRC2 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves NHLRC2 34
  • 74.43 (n)
  • 75.87 (a)
NHLRC2 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NHLRC2 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nhlrc2 34
  • 64.69 (n)
  • 66.57 (a)
zebrafish
(Danio rerio)
Actinopterygii nhlrc2 35
  • 60 (a)
OneToMany
NHLRC2 (1 of 2) 35
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010610 34
  • 49.53 (n)
  • 46.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12547 34
  • 52.67 (n)
  • 46.03 (a)
CG12547 35
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G56500 34
  • 50.18 (n)
  • 42.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.297 35
  • 28 (a)
OneToOne
Species where no ortholog for NHLRC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHLRC2 Gene

ENSEMBL:
Gene Tree for NHLRC2 (if available)
TreeFam:
Gene Tree for NHLRC2 (if available)

Paralogs for NHLRC2 Gene

(1) SIMAP similar genes for NHLRC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NHLRC2: view

No data available for Paralogs for NHLRC2 Gene

Variants for NHLRC2 Gene

Sequence variations from dbSNP and Humsavar for NHLRC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7913176 - 113,884,281(+) GCACT(A/G)TAGCT reference, missense
rs3841343 -- 113,902,328(+) AGTAT(-/C)CAACC intron-variant
rs7894115 -- 113,899,681(+) ttggg(A/G)ggccg intron-variant
rs4244310 -- 113,904,402(+) TAAAA(G/T)AAACA intron-variant
rs7895675 -- 113,887,682(+) tggga(A/G)aatca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NHLRC2 Gene

Variant ID Type Subtype PubMed ID
nsv428238 CNV loss 18775914
nsv517356 CNV gain+loss 19592680
nsv525892 CNV loss 19592680
nsv552201 CNV loss 21841781
nsv7211 OTHER inversion 18451855
nsv831995 CNV gain+loss 17160897

Variation tolerance for NHLRC2 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.80; 86.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NHLRC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NHLRC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHLRC2 Gene

Disorders for NHLRC2 Gene

Relevant External Links for NHLRC2

Genetic Association Database (GAD)
NHLRC2
Human Genome Epidemiology (HuGE) Navigator
NHLRC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NHLRC2

No disorders were found for NHLRC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NHLRC2 Gene

Publications for NHLRC2 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 65
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 65

Products for NHLRC2 Gene

Sources for NHLRC2 Gene

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