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Aliases for NHLRC2 Gene

Aliases for NHLRC2 Gene

  • NHL Repeat Containing 2 2 3
  • Novel NHL Repeat Domain Containing Protein 3
  • NHL Repeat-Containing Protein 2 3
  • 1200003G01Rik 3

External Ids for NHLRC2 Gene

Previous GeneCards Identifiers for NHLRC2 Gene

  • GC10P115280
  • GC10P115604
  • GC10P109241

Summaries for NHLRC2 Gene

GeneCards Summary for NHLRC2 Gene

NHLRC2 (NHL Repeat Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLRC2 Gene

Genomics for NHLRC2 Gene

Regulatory Elements for NHLRC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NHLRC2 Gene

113,854,632 bp from pter
113,917,194 bp from pter
62,563 bases
Plus strand

Genomic View for NHLRC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NHLRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLRC2 Gene

Proteins for NHLRC2 Gene

  • Protein details for NHLRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NHL repeat-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8N1H1
    • Q8N5A6

    Protein attributes for NHLRC2 Gene

    726 amino acids
    Molecular mass:
    79444 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05316.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NHLRC2 Gene


neXtProt entry for NHLRC2 Gene

Proteomics data for NHLRC2 Gene at MOPED

Post-translational modifications for NHLRC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NHLRC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NHLRC2 Gene

Domains for NHLRC2 Gene

Protein Domains for NHLRC2 Gene

Suggested Antigen Peptide Sequences for NHLRC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Contains 6 NHL repeats.
  • Contains 1 thioredoxin domain.
  • Contains 6 NHL repeats.
genes like me logo Genes that share domains with NHLRC2: view

No data available for Gene Families for NHLRC2 Gene

Function for NHLRC2 Gene

Gene Ontology (GO) - Molecular Function for NHLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NHLRC2: view

Animal Model Products

miRNA for NHLRC2 Gene

miRTarBase miRNAs that target NHLRC2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NHLRC2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for NHLRC2 Gene

Localization for NHLRC2 Gene

Subcellular locations from

Jensen Localization Image for NHLRC2 Gene COMPARTMENTS Subcellular localization image for NHLRC2 gene
Compartment Confidence
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NHLRC2 Gene

Pathways for NHLRC2 Gene

SuperPathways for NHLRC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NHLRC2 Gene


No data available for Pathways by source for NHLRC2 Gene

Transcripts for NHLRC2 Gene

mRNA/cDNA for NHLRC2 Gene

Unigene Clusters for NHLRC2 Gene

NHL repeat containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NHLRC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHLRC2 Gene

No ASD Table

Relevant External Links for NHLRC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHLRC2 Gene

mRNA expression in normal human tissues for NHLRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NHLRC2 Gene

This gene is overexpressed in Uterus (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NHLRC2 Gene

SOURCE GeneReport for Unigene cluster for NHLRC2 Gene Hs.369924

genes like me logo Genes that share expressions with NHLRC2: view

Expression partners for NHLRC2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NHLRC2 Gene

Orthologs for NHLRC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NHLRC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NHLRC2 35
  • 90.13 (n)
  • 90.22 (a)
  • 90 (a)
(Canis familiaris)
Mammalia NHLRC2 35
  • 91.41 (n)
  • 90.77 (a)
  • 85 (a)
(Mus musculus)
Mammalia Nhlrc2 35
  • 82.57 (n)
  • 84 (a)
Nhlrc2 16
Nhlrc2 36
  • 84 (a)
(Pan troglodytes)
Mammalia NHLRC2 35
  • 99.4 (n)
  • 99.04 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Nhlrc2 35
  • 81.15 (n)
  • 83.72 (a)
(Monodelphis domestica)
Mammalia NHLRC2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia NHLRC2 36
  • 80 (a)
(Gallus gallus)
Aves NHLRC2 35
  • 74.43 (n)
  • 75.87 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia NHLRC2 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nhlrc2 35
  • 64.69 (n)
  • 66.57 (a)
(Danio rerio)
Actinopterygii nhlrc2 36
  • 60 (a)
NHLRC2 (1 of 2) 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010610 35
  • 49.53 (n)
  • 46.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12547 35
  • 52.67 (n)
  • 46.03 (a)
CG12547 36
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G56500 35
  • 50.18 (n)
  • 42.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.297 36
  • 28 (a)
Species with no ortholog for NHLRC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHLRC2 Gene

Gene Tree for NHLRC2 (if available)
Gene Tree for NHLRC2 (if available)

Paralogs for NHLRC2 Gene

(1) SIMAP similar genes for NHLRC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NHLRC2: view

No data available for Paralogs for NHLRC2 Gene

Variants for NHLRC2 Gene

Sequence variations from dbSNP and Humsavar for NHLRC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2301180 -- 113,858,487(-) GAGAA(A/G)GATAA intron-variant
rs2419857 -- 113,857,617(-) AATAA(C/T)TCAAT intron-variant
rs3841343 -- 113,902,328(+) AGTAT(-/C)CAACC intron-variant
rs4133166 -- 113,893,841(+) AGGCT(C/T)TAAAA intron-variant
rs4244310 -- 113,904,402(+) TAAAA(G/T)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NHLRC2 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831995 CNV Gain+Loss 17160897
nsv896016 CNV Loss 21882294
nsv525892 CNV Loss 19592680
nsv428238 CNV Loss 18775914
nsv517356 CNV Gain+Loss 19592680

Relevant External Links for NHLRC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHLRC2 Gene

Disorders for NHLRC2 Gene

Relevant External Links for NHLRC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NHLRC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NHLRC2 Gene

Publications for NHLRC2 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for NHLRC2 Gene

Sources for NHLRC2 Gene

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