NHLRC2 Gene
protein-coding GIFtS : 43
GCID: GC10 P115604
NHL repeat containing 2
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Aliasesfor NHLRC2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases NHL Repeat Containing 2 1 2 MGC454921 DKFZp779F1151 1200003G01Rik2 FLJ201471 NHL Repeat-Containing Protein 22 FLJ256211 Novel NHL Repeat Domain Containing Protein2 FLJ333121
Export aliases for NHLRC2 gene to outside databases Previous GC identifers: GC10P115280 GC10P109241
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Summariesfor NHLRC2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor NHLRC2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_030059.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NHLRC2 gene promoter: CREB LHX3b/Lhx3b AML1a p53 LHX3a/Lhx3a ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for NHLRC2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NHLRC2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q25.3 Ensembl cytogenetic band: 10q25.3 HGNC cytogenetic band: 10q26.11 NHLRC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P115604: view genomic region
(about GC identifiers )
Start:
115,614,391 bp from pter
End:
115,676,953 bp from pter
Size:
62,563 bases
Orientation:
plus strand
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Proteinsfor NHLRC2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NHLC2_HUMAN, Q8NBF2 (See
protein sequence )Recommended Name: NHL repeat-containing protein 2 Size : 726 amino acids; 79444 Da
Sequence caution : Sequence=BAC05316.1; Type=Erroneous initiation;
Secondary accessions : Q8N1H1 Q8N5A6Alternative splicing : 2 isoforms : Q8NBF2-1 Q8NBF2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NHLRC2: NX_Q8NBF2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8NBF2 NHLRC2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_940916.2 ENSEMBL proteins: ENSP00000358307 Human Recombinant Protein Products for NHLRC2: NHLRC2 Antibody Products: Assay Products for NHLRC2:
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Protein
Domains / Familiesfor NHLRC2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NHLRC2 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8NBF2 ProtoNet protein and cluster: Q8NBF2
UniProtKB/Swiss-Prot: NHLC2_HUMAN, Q8NBF2 Similarity : Contains 6 NHL repeatsSimilarity : Contains 1 thioredoxin domain
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Functionfor NHLRC2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NHLRC2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NHLRC2OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NHLRC2 (NM_198514 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NHLRC2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NHLRC2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLRC2
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Pathways & Interactionsfor NHLRC2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NHLRC2 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for NHLRC2 (ENSP00000358307 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor NHLRC2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NHLRC2 Search CenterWatch for drugs/clinical trials and news about NHLRC2 / NHLC2
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Transcriptsfor NHLRC2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NHLRC2 gene: NM_198514.3 Unigene Clusters for NHLRC2:
NHL repeat containing 2 Hs.369924 [show with all ESTs ] , Hs.594372 [show with all ESTs ] Unigene Representative Sequences: NM_198514 , BX647663 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000369301 (uc001lax.2 uc001lay.2 ) ENST00000468890 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NHLRC2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NHLRC2OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NHLRC2 (NM_198514 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NHLRC2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NHLRC2
Additional cDNA sequence: AK000154.1 AK094313.1 AK126751.1 BC013743.1 BX647663.1
5 DOTS entries : DT.301063 DT.99994591
DT.91699297 DT.212610 DT.75101063 24/44 AceView cDNA sequences (see all 44 ):
BX363962 CR593205 AL042780 BU676899 BX538287 AL832090 AK098487 CB105353 AK090631 BX119297 BM453028 AX746547 NM_198514 BX328292 AI423825 AW169943 CA415420 AI678304 AW105072 BC032598 BX352611 AW968226 AA824494 BX647641 GeneLoc Exon Structure
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Expression for NHLRC2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NHLRC2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGTTAACAGAAbout this image NHLRC2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Neural Tube Telencephalon Neural Tube Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See NHLRC2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NHLRC2 SOURCE GeneReport for Unigene clusters: Hs.369924 Hs.594372 SABiosciences Custom PCR Arrays for NHLRC2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NHLRC2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat NHLRC2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NHLRC2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NHLRC2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLRC2
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Orthologsfor NHLRC2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for NHLRC2 gene from 7/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for NHLRC2 (if available)TreeFam Gene Tree for NHLRC2 (if available)
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Paralogsfor NHLRC2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor NHLRC2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 10 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for NHLRC2 (115614391 - 115676953 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for NHLRC2 2 CNVs : 48414 4713
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NHLRC2
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Disorders
/ Diseasesfor NHLRC2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
NHLRC2 for disorders About GeneDecksing 3 diseases for NHLRC2 : About MalaCards alzheimer's disease tuberculosis mycobacterium tuberculosis Human Genome Epidemiology (HuGE) Navigator: NHLRC2 (1 document)Export disorders for NHLRC2 gene to outside databases
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Publicationsfor NHLRC2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NHLRC2 gene integrated from 9 sources : (articles sorted by number of sources associating them with NHLRC2) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883) 1 Kristensen A.R....Foster L.J. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451) 1 Grupe A....Goate A. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054) 2 Deloukas P.... Rogers J. (2004)
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External Searches for NHLRC2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NHLRC2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NHLRC2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing NHLRC2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for NHLRC2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NHLRC2 gene: Search GeneIP for patents involving NHLRC2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NHLRC2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for NHLRC2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NHLRC2 OriGene Protein Over-expression Lysate for NHLRC2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NHLRC2 OriGene 3'-UTR Clone for NHLRC2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NHLRC2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NHLRC2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for NHLRC2 OriGene Custom Protein Services for NHLRC2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NHLRC2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NHLRC2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NHLRC2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat NHLRC2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NHLRC2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NHLRC2
Search Tocris compounds for NHLRC2
NHLRC2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLRC2
Search ThermoFisher Antibodies for NHLRC2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NHLRC2
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Databases for NHLRC2
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Drugs / Compounds for NHLRC2
Expression for NHLRC2
Function for NHLRC2
Genomic Views for NHLRC2
Intellectual Property for NHLRC2
Orthologs for NHLRC2
Paralogs for NHLRC2
Pathways / Interactions for NHLRC2
Products for NHLRC2
Proteins for NHLRC2
Publications for NHLRC2
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Summaries for NHLRC2
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Variants for NHLRC2
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